CN108836888A - A kind of tooth antiallergic composition - Google Patents
A kind of tooth antiallergic composition Download PDFInfo
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- CN108836888A CN108836888A CN201810382428.5A CN201810382428A CN108836888A CN 108836888 A CN108836888 A CN 108836888A CN 201810382428 A CN201810382428 A CN 201810382428A CN 108836888 A CN108836888 A CN 108836888A
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- agent
- stabilizer
- value adjustment
- tooth
- antibacterial agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses a kind of tooth antiallergic compositions, including anti-sensitizer, pH value adjustment agent, stabilizer, wide-spectrum bactericide and deionized water；The weight percent of each component is as follows：1) 1%~2.5% antibacterial agent, the antibacterial agent include sylvite, strontium chloride and Paeonol；2) 0.3%~1.5% pH value adjustment agent, the pH value adjustment agent are sodium hydroxide；3) 0.5%~2% stabilizer, the stabilizer is sodium pyrophosphate, calgon, sodium tripolyphosphate, sodium tripolyphosphate potassium, one or more of in edetate；4) 0.1~0.5% broad spectrum antimicrobial agent, the broad spectrum antimicrobial agent are 0- cymene -5- alcohol；5) surplus is deionized water.Heretofore described tooth antiallergic composition has the function of pre- anti-caries while alleviating sensitivity of tooth；And being used for a long time not will lead to dependence.
Description
Technical field
The invention belongs to oral health preparation field, in particular to a kind of tooth antiallergic composition.
Background technique
Hemodia is ached, clinically referred to as hypersensitive dentin, is tooth by environmental stimuli, such as hot and cold, sour, sweet tea
The stimulation of food and hard object is stung, symptom of aching as caused by small walnut, pine nut etc..Hypersensitive dentin disease incidence be 8%~
30%, it is common disease, the frequently-occurring disease of clinical oral that 40 years old or so, which is group of people at high risk,.The symptom and inducement that hypersensitive dentin is related to
It is relatively broad, such as：Wedge-shaped defect, periodontal atrophy, Root exposnre, tooth trauma, dentine exposure, serious abrasion, tooth body are pre-
Standby, hole type preparation, toothwash etc..The main disease hair of dental hypersensitiveness is the reason is that situations such as occurring impaired enamel or gingival atrophy
When, exposed dentinal tubule is in open state, and the liquid in dentinal tubule occurs for air, hypertonic solution or thermal stimulus
Change in flow mechanically stirs dental pulp content, and then indirect excitation free nerve ending therein, causes to get excited, generates pain
Feel.
Dental pulp disease expert proposes six aspects for the treatment of hypersensitive dentin：1) physical method closing or blocking dentine are small
The outer end of pipe；2) plasm of chemical method solidification dentine；3) chemical substance reacted with dental tissue to be formed precipitating, blocking it is small
Pipe；4) dentinal permeability, the nearly marrow end of closing dentinal tubule are induced；5) anesthesia speciality penetrates into dental pulp through tubule, blocks dental pulp mind
Through tip；6) some substances penetrate into dental pulp through tubule, inhibit the excitation of Intradental nerve.Summarize the above treatment method, the above treatment
Method is based primarily upon the permeability for changing dentinal tubule and reduces the excitability of Intradental nerve to carry out improvement dentin hypersensitiveness
Shape.
Sylvite desensitization is usually used in current composition for desensitizing teeth some on the market, and mechanism is：Contained in sylvite
Potassium ion releases, and potassium ion enters in the tubule of dentine, has affinity interaction with nerve endings, improves nerve impulse
Transmitting, pass through the signal of inhibition of Chemical Reaction nerve endings conducting pain, it is suppressed that dental nerve in mineralising, to reduce tooth
Spinal nerve is anaesthetized Intradental nerve, is relieved pain to hot and cold, sour, sweet tea excitability and sensibility.If at one section of continuous use
Between, potassium ion in dentinal tubule can be made to reach certain dynamic equilibrium, effect more continuous and effective.
But the existing composition for preventing and treating hypersensitive dentin, that there are compositions is unstable, is easy to produce dependence, and
There can be the potential danger that harm is generated to human body.
Summary of the invention
The present invention provides a kind of tooth antiallergic composition, present invention antiallergic ingredient containing there are three types of, and its composition stabilization is deposited
When long-term harm will not be being generated to human body.
To achieve the above object, the present invention adopts the following technical solutions.
A kind of tooth antiallergic composition, including anti-sensitizer, pH value adjustment agent, stabilizer, wide-spectrum bactericide and deionized water；
The weight percent of each component is as follows：
1) 1%~2.5% antibacterial agent, the antibacterial agent include sylvite, strontium chloride and Paeonol；
2) 0.3%~1.5% pH value adjustment agent, the pH value adjustment agent are sodium hydroxide；
3) 0.5%~2% stabilizer, the stabilizer are sodium pyrophosphate, calgon, sodium tripolyphosphate, trimerization
It is one or more of in potassium-sodium phosphates, edetate；
4) 0.1~0.5% broad spectrum antimicrobial agent, the broad spectrum antimicrobial agent are 0- cymene -5- alcohol；
5) surplus is deionized water.
Further, the sylvite in the antibacterial agent be dipotassium glycyrrhizinate, potassium fluoride, it is one or more of in potassium chloride.
Further, the ratio of sylvite, strontium chloride and Paeonol is 3 in the antibacterial agent:2:1.5.
Beneficial effects of the present invention are：Anti-sensitizer uses this three kinds of ingredients of sylvite, strontium chloride and Paeonol in the present invention
It is combined, one side sylvite discharges potassium ion fast pain relief (excitability for reducing Intradental nerve), and strontium is human body
A kind of interior microelement, and the overwhelming majority exists in bone tissue, and the structure of the adjustable bone tissue of strontium element improves bone
Intensity, promote the physiological activity of osteocyte, promote the deposition of bone salts；Another aspect Paeonol is from Ranunculaceae densification tree peony
A kind of effective component extracted in dry root skin has the function of throe, anti-inflammatory and inhibition allergy；Therefore sylvite,
Strontium oxide strontia and Paeonol act synergistically, and considerably increase the curative effect of the composition, and sylvite, strontium chloride and Paeonol this three
Kind component chemistry is stablized, and long-time service not will lead to dependence；It is anti-that wide spectrum is additionally added in the tooth antiallergic composition
Microbial inoculum can make the growth of certain micro-organisms (bacterium, fungi, virus etc.) or breeding be maintained at necessary water within a certain period of time
It puts down hereinafter, making heretofore described tooth antiallergic composition function with pre- anti-caries while alleviating sensitivity of tooth
Energy.
Specific embodiment
The present invention will be further explained with reference to the examples below.Embodiments of the present invention are including but not limited to following
Embodiment.
Following non-limiting embodiment is further discussed below the preferred embodiment in the scope of the invention.Without departing substantially from the present invention
In the case where range, many variations of the present embodiment are possible.
Embodiment 1
A kind of tooth antiallergic composition, including anti-sensitizer, pH value adjustment agent, stabilizer, wide-spectrum bactericide and deionized water；
The weight percent of each component is as follows：
1) 1% antibacterial agent, the antibacterial agent include dipotassium glycyrrhizinate, strontium chloride and Paeonol；
2) 0.3% pH value adjustment agent, the pH value adjustment agent are sodium hydroxide；
3) 0.5% stabilizer, the stabilizer are sodium pyrophosphate；
4) 0.1% broad spectrum antimicrobial agent, the broad spectrum antimicrobial agent are 0- cymene -5- alcohol；
5) surplus is deionized water.
The ratio of dipotassium glycyrrhizinate, strontium chloride and Paeonol is 3 in the antibacterial agent:2:1.5.
Embodiment 2
A kind of tooth antiallergic composition, including anti-sensitizer, pH value adjustment agent, stabilizer, wide-spectrum bactericide and deionized water；
The weight percent of each component is as follows：
1) 2.5% antibacterial agent, the antibacterial agent include potassium fluoride, strontium chloride and Paeonol；
2) 1.5% pH value adjustment agent, the pH value adjustment agent are sodium hydroxide；
3) 2% stabilizer, the stabilizer are sodium pyrophosphate, calgon in mass fraction ratio 1:1.2 proportion
Composition；
4) 0.5% broad spectrum antimicrobial agent, the broad spectrum antimicrobial agent are 0- cymene -5- alcohol；
5) surplus is deionized water.
The mass fraction ratio of potassium fluoride, strontium chloride and Paeonol is 3 in the antibacterial agent:2:1.5.
Embodiment 3
A kind of tooth antiallergic composition, including anti-sensitizer, pH value adjustment agent, stabilizer, wide-spectrum bactericide and deionized water；
The weight percent of each component is as follows：
1) 2% antibacterial agent, the antibacterial agent include potassium chloride, strontium chloride and Paeonol；
2) 1.1% pH value adjustment agent, the pH value adjustment agent are sodium hydroxide；
3) 1.2% stabilizer, the stabilizer are sodium pyrophosphate, calgon, sodium tripolyphosphate, sodium tripolyphosphate
Potassium, edetate are in mass fraction ratio 1:1.5:2:2.5:The composition of 3 proportions；
4) 0.4% broad spectrum antimicrobial agent, the broad spectrum antimicrobial agent are 0- cymene -5- alcohol；
5) surplus is deionized water.
The ratio of potassium chloride, strontium chloride and Paeonol is 3 in the antibacterial agent:2:1.5.
100 easy autopaths of tooth are divided into 4 groups, in Examples 1 to 3 three kinds of tooth antiallergic compositions and
Conventional hemodia symptom composition of eliminating is tested at present.Each group patient is after receiving various stimulations, respectively using above-mentioned
Three kinds of compositions and conventional elimination hemodia symptom composition, observe a patient and react after.By test result it is found that this hair
Bright composition can quickly eliminate hemodia symptom.The present invention does not limit to and above embodiment, and anyone should learn that at this
The structure change made under the enlightenment of invention, the technical schemes that are same or similar to the present invention each fall within the present invention
Protection scope within.
Claims (3)
1. a kind of tooth antiallergic composition, which is characterized in that including anti-sensitizer, pH value adjustment agent, stabilizer, wide-spectrum bactericide and
Deionized water；The weight percent of each component is as follows：
1) 1%~2.5% antibacterial agent, the antibacterial agent include sylvite, strontium chloride and Paeonol；
2) 0.3%~1.5% pH value adjustment agent, the pH value adjustment agent are sodium hydroxide；
3) 0.5%~2% stabilizer, the stabilizer are sodium pyrophosphate, calgon, sodium tripolyphosphate, tripolyphosphate
It is one or more of in sodium potassium, edetate；
4) 0.1~0.5% broad spectrum antimicrobial agent, the broad spectrum antimicrobial agent are 0- cymene -5- alcohol；
5) surplus is deionized water.
2. a kind of tooth antiallergic composition according to claim 1, which is characterized in that the sylvite in the antibacterial agent is sweet
It is oxalic acid dipotassium, potassium fluoride, one or more of in potassium chloride.
3. a kind of tooth antiallergic composition according to claim 1, which is characterized in that sylvite, chlorination in the antibacterial agent
The ratio of strontium and Paeonol is 3:2:1.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810382428.5A CN108836888A (en) | 2018-04-25 | 2018-04-25 | A kind of tooth antiallergic composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810382428.5A CN108836888A (en) | 2018-04-25 | 2018-04-25 | A kind of tooth antiallergic composition |
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| Publication Number | Publication Date |
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| CN108836888A true CN108836888A (en) | 2018-11-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810382428.5A Pending CN108836888A (en) | 2018-04-25 | 2018-04-25 | A kind of tooth antiallergic composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330986A (en) * | 2018-12-26 | 2019-02-15 | 白昀易 | The buccal tablet and preparation method thereof of anti-hemodia |
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|---|---|---|---|---|
| CN101766551A (en) * | 2010-03-30 | 2010-07-07 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
| CN102860971A (en) * | 2012-09-19 | 2013-01-09 | 江苏江大源生态生物科技有限公司 | Compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and preparation method thereof |
| CN104352368A (en) * | 2014-09-30 | 2015-02-18 | 青岛叁鼎卫生制品有限公司 | Acid-proof and antibacterial multi-effect toothpaste |
| CN106619269A (en) * | 2016-10-14 | 2017-05-10 | 柳州环山科技有限公司 | Antiphlogosis antiallergic mouthwash and preparation method thereof |
| CN107028799A (en) * | 2017-02-21 | 2017-08-11 | 广州薇美姿实业有限公司 | A kind of oral cavity baste of antiallergic whitening |
| CN107485584A (en) * | 2017-07-28 | 2017-12-19 | 鹰仕达（中国）有限公司 | A kind of oral care composition |
| CN107595750A (en) * | 2017-07-28 | 2018-01-19 | Dj健康产业集团 | A kind of active inflammation-diminishing toothpaste |
-
2018
- 2018-04-25 CN CN201810382428.5A patent/CN108836888A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766551A (en) * | 2010-03-30 | 2010-07-07 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
| CN102860971A (en) * | 2012-09-19 | 2013-01-09 | 江苏江大源生态生物科技有限公司 | Compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and preparation method thereof |
| CN104352368A (en) * | 2014-09-30 | 2015-02-18 | 青岛叁鼎卫生制品有限公司 | Acid-proof and antibacterial multi-effect toothpaste |
| CN106619269A (en) * | 2016-10-14 | 2017-05-10 | 柳州环山科技有限公司 | Antiphlogosis antiallergic mouthwash and preparation method thereof |
| CN107028799A (en) * | 2017-02-21 | 2017-08-11 | 广州薇美姿实业有限公司 | A kind of oral cavity baste of antiallergic whitening |
| CN107485584A (en) * | 2017-07-28 | 2017-12-19 | 鹰仕达（中国）有限公司 | A kind of oral care composition |
| CN107595750A (en) * | 2017-07-28 | 2018-01-19 | Dj健康产业集团 | A kind of active inflammation-diminishing toothpaste |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330986A (en) * | 2018-12-26 | 2019-02-15 | 白昀易 | The buccal tablet and preparation method thereof of anti-hemodia |
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Application publication date: 20181120 |