CN105769924A - Propolis oral antifungal cream and preparing method thereof - Google Patents
Propolis oral antifungal cream and preparing method thereof Download PDFInfo
- Publication number
- CN105769924A CN105769924A CN201610234468.6A CN201610234468A CN105769924A CN 105769924 A CN105769924 A CN 105769924A CN 201610234468 A CN201610234468 A CN 201610234468A CN 105769924 A CN105769924 A CN 105769924A
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- Prior art keywords
- propolis
- sodium
- cream
- paeonol
- chlorhexidine acetate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Insects & Arthropods (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a propolis oral antifungal cream with a good antifungal effect.The propolis oral antifungal cream is prepared from, by weight, 0.4-0.7% of propolis, 0.08-0.12% of chlorhexidine acetate and 0.03-0.08% of paeonol.The invention further discloses a preparing method of the propolis oral antifungal cream.
Description
Technical field
The invention belongs to household chemicals field, particularly a kind of propolis oral bacteriostasis cream and preparation method thereof.
Background technology
Chinese patent CN 03118084.1 discloses a kind of oral cavity bacteriostatic composition, and it comprises the leaf of Cyclocarya paliurus Iljinskaja of safe and effective amount
Extract and oral cavity acceptable carrier.Its carrier can be toothpaste, dentifrice, collutory, spray etc..
Chinese patent CN 201410069332.5 discloses a kind of oral mykoses antibacterial, and this fungus antibacterial is by following former
Material and weight ratio composition: Poria 10-45 weight portion, Herba Taraxaci 5-40 weight portion, Semen Coicis 5-40 weight portion, Semen Armeniacae Amarum 5-40
Weight portion, roud cardamon seed 5-40 weight portion, Rhizoma Pinelliae Preparatum 5-40 weight portion, Semen Sojae Preparatum 3-30 weight portion, Cortex Magnoliae Officinalis 3-30 weight
Part, Rhizoma Chuanxiong 3-30 weight portion, Folium Bambusae 1-10 weight portion, Medulla Tetrapanacis 1-10 weight, Herba Hedyotidis Diffusae 1-30 weight portion.Should
Invention additionally provides preparation method and the particular use of this fungus antibacterial.Test proves that white is read by this fungus antibacterial
The funguses such as pearl bacterium have stronger antibacterial activity, and buccal cavity fungal infection patient is had preferable therapeutical effect.
Existing product fungistatic effect is to be improved.
Summary of the invention
It is an object of the invention to provide the propolis oral bacteriostasis cream of a kind of good antimicrobial effect, the invention also discloses its system simultaneously
Preparation Method.
Additionally, another object of the present invention is to provide the preparation method of above-mentioned propolis oral bacteriostasis cream.
The technical scheme is that a kind of propolis oral bacteriostasis cream, described propolis oral bacteriostasis cream contains following weight hundred
The component of mark: 0.4wt%-0.7wt% propolis, 0.08wt%-0.12wt% chlorhexidine acetate, 0.03wt%-0.08wt% Cortex Moutan
Phenol.
In above-mentioned propolis oral bacteriostasis cream, described propolis oral bacteriostasis cream is composed of the following components:
4wt%-6wt%PEG, 60wt%-67wt% sorbitol, 0.2wt%-0.7wt%CMC, 0.15wt%-0.3wt% xanthan gum,
0.15wt%-0.3wt% carrageenan, 11wt%-19wt% silicon dioxide, 0.9wt%-2.4wt% sodium lauryl sulphate,
0.05wt%-0.2wt% saccharin sodium, 0.1wt%-0.5wt% sodium benzoate, 0.1wt%-0.5wt% sodium pyrophosphate,
0.4wt%-0.7wt% propolis, 0.08wt%-0.12wt% chlorhexidine acetate, 0.5wt%-0.9wt% essence, 0.1wt%-0.5wt%
Mentholum, 0.1wt%-0.5wt% Borneolum Syntheticum, 0.1wt%-0.4wt% calcium carbonate, 0.02wt%-0.05wt%WS-23,
7.1wt%-10.5wt% water, 0.03wt%-0.08wt% paeonol.
In above-mentioned propolis oral bacteriostasis cream, composed of the following components:
PEG 5wt%
Sorbitol 63wt%
CMC 0.4wt%
Xanthan gum 0.25wt%
Carrageenan 0.25wt%
Silica 1 7wt%
Sodium lauryl sulphate 2wt%
Saccharin sodium 0.15wt%
Sodium benzoate 0.3wt%
Sodium pyrophosphate 0.3wt%
Propolis 0.6wt%
Chlorhexidine acetate 0.1wt%
Essence 0.8wt%
Mentholum 0.3wt%
Borneolum Syntheticum 0.3wt%
Calcium carbonate 0.15wt%
WS-23 0.04wt%
Water 9.01wt%
Paeonol 0.05wt%.
Another object of the present invention is to provide the preparation method of above-mentioned propolis oral bacteriostasis cream, comprises the following steps:
Step 1: add weigh up water, silicon dioxide, calcium carbonate, kettle heat 75 DEG C of dissolvings；Pyrusussuriensis is added at oil cauldron
Alcohol, PEG400, xanthan gum, carrageenan, CMC, saccharin sodium, sodium benzoate, sodium pyrophosphate, paeonol, ten
Sodium dialkyl sulfate, chlorhexidine acetate, Mentholum, Borneolum Syntheticum, WS-23 heat 75 DEG C of dissolvings；
Step 2: by kettle, oil cauldron suction vacuum emulsifying machine respectively, homogenizing stirs, and is cooled to 40 DEG C and adds propolis, essence
Stir；
Step 3: be cooled to 38 DEG C of dischargings.
Beneficial effects of the present invention is as follows:
Component design of the present invention is the gingiva problem (gingival hemorrhage, gingiva pain) for present most of crowds, Ke Yiyou
The reparation mucosa injury of effect, alleviates a mouthful source property halitosis, and gingival sensitivity of releiving promotes that periodontal tissue is healthy.This product uses pure natural
Propolis coordinates Mentholum, Borneolum Syntheticum, paeonol etc., through the formula meticulously developed, has well tune to human teeth's gingiva
Joint and nursing antibacterial action.Recover dental health.
Detailed description of the invention
Below in conjunction with detailed description of the invention, technical scheme is described in further detail, but does not constitute this
Bright any restriction.
Embodiment 1
In a kind of propolis oral bacteriostasis cream, composed of the following components:
PEG 5wt%
Sorbitol 63wt%
CMC 0.4wt%
Xanthan gum 0.25wt%
Carrageenan 0.25wt%
Silica 1 7wt%
Sodium lauryl sulphate 2wt%
Saccharin sodium 0.15wt%
Sodium benzoate 0.3wt%
Sodium pyrophosphate 0.3wt%
Propolis 0.6wt%
Chlorhexidine acetate 0.1wt%
Essence 0.8wt%
Mentholum 0.3wt%
Borneolum Syntheticum 0.3wt%
Calcium carbonate 0.15wt%
WS-23 0.04wt%
Water 9.01wt%
Paeonol 0.05wt%..
Its preparation method is particularly as follows: step 1: add weigh up water, silicon dioxide, calcium carbonate, kettle heat 75 DEG C molten
Solve；Sorbitol, PEG400, xanthan gum, carrageenan, CMC, saccharin sodium, sodium benzoate, Jiao is added at oil cauldron
Sodium phosphate, paeonol, sodium lauryl sulphate, chlorhexidine acetate, Mentholum, Borneolum Syntheticum, WS-23 heat 75 DEG C of dissolvings；
Step 2: by kettle, oil cauldron suction vacuum emulsifying machine respectively, homogenizing stirs, and is cooled to 40 DEG C and adds propolis, essence
Stir；
Step 3: be cooled to 38 DEG C of dischargings.
Embodiment 2
In a kind of propolis oral bacteriostasis cream, composed of the following components:
PEG 6wt%
Sorbitol 67wt%
CMC 0.7wt%
Xanthan gum 0.3wt%
Carrageenan 0.3wt%
Silica 1 2wt%
Sodium lauryl sulphate 1wt%
Saccharin sodium 0.05wt%
Sodium benzoate 0.1wt%
Sodium pyrophosphate 0.1wt%
Propolis 0.4wt%
Chlorhexidine acetate 0.08wt%
Essence 0.5wt%
Mentholum 0.1wt%
Borneolum Syntheticum 0.4wt%
Calcium carbonate 0.4wt%
WS-23 0.04wt%
Water 10.5wt%
Paeonol 0.03wt%.
Its preparation method is particularly as follows: step 1: add weigh up water, silicon dioxide, calcium carbonate, kettle heat 75 DEG C molten
Solve；Sorbitol, PEG400, xanthan gum, carrageenan, CMC, saccharin sodium, sodium benzoate, Jiao is added at oil cauldron
Sodium phosphate, paeonol, sodium lauryl sulphate, chlorhexidine acetate, Mentholum, Borneolum Syntheticum, WS-23 heat 75 DEG C of dissolvings；
Step 2: by kettle, oil cauldron suction vacuum emulsifying machine respectively, homogenizing stirs, and is cooled to 40 DEG C and adds propolis, essence
Stir；
Step 3: be cooled to 38 DEG C of dischargings.
Embodiment 3
In a kind of propolis oral bacteriostasis cream, composed of the following components:
PEG4wt%
Sorbitol 62wt%
CMC 0.2wt%
Xanthan gum 0.15wt%
Carrageenan 0.15wt%
Silica 1 9wt%
Sodium lauryl sulphate 2.4wt%
Saccharin sodium 0.2wt%
Sodium benzoate 0.5wt%
Sodium pyrophosphate 0.5wt%
Propolis 0.7wt%
Chlorhexidine acetate 0.12wt%
Essence 0.9wt%
Mentholum 0.5wt%
Borneolum Syntheticum 0.1wt%
Calcium carbonate 0.1wt%
WS-23 0.02wt%
Water 8.68wt%
Paeonol 0.08wt%.
Its preparation method is particularly as follows: step 1: add weigh up water, silicon dioxide, calcium carbonate, kettle heat 75 DEG C molten
Solve；Sorbitol, PEG400, xanthan gum, carrageenan, CMC, saccharin sodium, sodium benzoate, Jiao is added at oil cauldron
Sodium phosphate, paeonol, sodium lauryl sulphate, chlorhexidine acetate, Mentholum, Borneolum Syntheticum, WS-23 heat 75 DEG C of dissolvings；
Step 2: by kettle, oil cauldron suction vacuum emulsifying machine respectively, homogenizing stirs, and is cooled to 40 DEG C and adds propolis, essence
Stir；
Step 3: be cooled to 38 DEG C of dischargings.
Performance test
1.1 appearance index
This product is yellow to brown-black mastic, and mastic is uniform, the impurity being visible by naked eyes, gas fragrance.
1.2 physical and chemical index
Table 1 should be met specify.
Table 1 physicochemical requirements
1.3 net contents and minus deviation
" quantification packing commodity metrological supervision and administration way " State Administration for Quality Supervision and Inspection and Quarantine should be met and make the 75th
Number regulation.
1.4 microbiological indicator
Table 2 should be met specify.
Table 2 micro-biology experiment
1.5 antibacterial requirements
Bacteriostatic test should meet the regulation of table 3
The antibacterial index of table 3, GB GB8372 of the toothpaste of reference
The antibacterial index of table 3
| Project | Concentration | Antibacterial ring |
| Staphylococcus aureus (8099) | Former medicine | ＞ 7.0mm |
| Escherichia coli (ATCC6538) | Former medicine | ＞ 7.0mm |
| Candida albicans (ATCC10231) | Former medicine | ＞ 7.0mm |
1.6 toxicological safety requirements
The most irritation tests: former medicine is non-stimulated to skin, or have slight zest.
1.6.2 the perverse clear test of eye: former medicine to eye without perverse clear, or the most perverse gargling property.
The above-described presently preferred embodiments of the present invention that is only, all made in the range of the spirit and principles in the present invention any repair
Change, equivalent and improvement etc., should be included within the scope of the present invention.
Claims (4)
1. a propolis oral bacteriostasis cream, it is characterised in that described propolis oral bacteriostasis cream contains following percetage by weight
Component: 0.4wt%-0.7wt% propolis, 0.08wt%-0.12wt% chlorhexidine acetate, 0.03wt%-0.08wt% paeonol.
Propolis oral bacteriostasis cream the most according to claim 1, it is characterised in that described propolis oral bacteriostasis cream by
Following components form: 4wt%-6wt%PEG, 60wt%-67wt% sorbitol, 0.2wt%-0.7wt%CMC,
0.15wt%-0.3wt% xanthan gum, 0.15wt%-0.3wt% carrageenan, 11wt%-19wt% silicon dioxide, 0.9wt%-2.4wt%
Sodium lauryl sulphate, 0.05wt%-0.2wt% sodium saccharin sodium, 0.1wt%-0.5wt% sodium benzoate, 0.1wt%-0.5wt% are burnt
Sodium phosphate, 0.4wt%-0.7wt% propolis, 0.08wt%-0.12wt% chlorhexidine acetate, 0.5wt%-0.9wt% essence,
0.1wt%-0.5wt% Mentholum, 0.1wt%-0.5wt% Borneolum Syntheticum, 0.1wt%-0.4wt% calcium carbonate,
0.02wt%-0.05wt%WS-23,7.1wt%-10.5wt% water, 0.03wt%-0.08wt% paeonol.
Propolis oral bacteriostasis cream the most according to claim 2, it is characterised in that composed of the following components:
PEG 5wt%
Sorbitol 63wt%
CMC 0.4wt%
Xanthan gum 0.25wt%
Carrageenan 0.25wt%
Silica 1 7wt%
Sodium lauryl sulphate 2wt%
Saccharin sodium 0.15wt%
Sodium benzoate 0.3wt%
Sodium pyrophosphate 0.3wt%
Propolis 0.6wt%
Chlorhexidine acetate 0.1wt%
Essence 0.8wt%
Mentholum 0.3wt%
Borneolum Syntheticum 0.3wt%
Calcium carbonate 0.15wt%
WS-23 0.04wt%
Water 9.01wt%
Paeonol 0.05wt%.
4. the preparation method of a propolis oral bacteriostasis cream as claimed in claim 2, it is characterised in that include following step
Rapid:
Step 1: add weigh up water, silicon dioxide, calcium carbonate, kettle heat 75 DEG C of dissolvings；Pyrusussuriensis is added at oil cauldron
Alcohol, PEG400, xanthan gum, carrageenan, CMC, saccharin sodium, sodium benzoate, sodium pyrophosphate, paeonol, ten
Sodium dialkyl sulfate, chlorhexidine acetate, Mentholum, Borneolum Syntheticum, WS-23 heat 75 DEG C of dissolvings；
Step 2: by kettle, oil cauldron suction vacuum emulsifying machine respectively, homogenizing stirs, and is cooled to 40 DEG C and adds propolis, essence
Stir；
Step 3: be cooled to 38 DEG C of dischargings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610234468.6A CN105769924A (en) | 2016-04-15 | 2016-04-15 | Propolis oral antifungal cream and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610234468.6A CN105769924A (en) | 2016-04-15 | 2016-04-15 | Propolis oral antifungal cream and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105769924A true CN105769924A (en) | 2016-07-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610234468.6A Pending CN105769924A (en) | 2016-04-15 | 2016-04-15 | Propolis oral antifungal cream and preparing method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860971A (en) * | 2012-09-19 | 2013-01-09 | 江苏江大源生态生物科技有限公司 | Compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and preparation method thereof |
| CN105125461A (en) * | 2015-08-18 | 2015-12-09 | 纳诺神蜂（福建）个人护理用品有限公司 | Compound propolis sustained-release toothpaste and preparation method thereof |
-
2016
- 2016-04-15 CN CN201610234468.6A patent/CN105769924A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860971A (en) * | 2012-09-19 | 2013-01-09 | 江苏江大源生态生物科技有限公司 | Compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and preparation method thereof |
| CN105125461A (en) * | 2015-08-18 | 2015-12-09 | 纳诺神蜂（福建）个人护理用品有限公司 | Compound propolis sustained-release toothpaste and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| TADEUSZ MORAWIEC ET AL.: "The Biological Activity of Propolis-Containing Toothpaste on Oral Health Environment in Patients Who Underwent Implant-Supported Prosthodontic Rehabilitation", 《HINDAWI PUBLISHING CORPORATION》 * |
| 姚刚等: "蜂胶及复合制剂在口腔健康中的应用", 《中国蜂业》 * |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20160720 |