CN107028799B

CN107028799B - Anti-allergy whitening oral cavity smearing liquid

Info

Publication number: CN107028799B
Application number: CN201710271855.1A
Authority: CN
Inventors: 陈敏珊; 曾晓宇; 谢晓芳; 李立芬
Original assignee: Guangzhou Weimeizi Industrial Co ltd
Current assignee: Guangzhou Shuke Industrial Co.,Ltd.
Priority date: 2017-02-21
Filing date: 2017-04-24
Publication date: 2020-05-12
Anticipated expiration: 2037-04-24
Also published as: CN107028799A

Abstract

The invention discloses an anti-allergy whitening oral cavity smearing liquid, which comprises, by weight, 0.1-5% of a whitening agent, 0.1-10% of an anti-allergy agent, 0.1-2% of a covering agent, 10-30% of a film forming agent, 50-80% of a solvent, 0.01-0.5% of a preservative, 0.01-2% of a buffering stabilizer, 0.01-1.5% of a flavoring agent and deionized water. The oral cavity smearing liquid can be directly smeared on teeth without using a mouth gag tool and can quickly form a film, so that the dual effects of whitening and anti-allergy are achieved for the teeth, the film is tightly attached to the tooth surface, the film can be kept not to fall off and dissolve even under the condition of chewing movement, foreign body feeling and sticky feeling are not generated when the oral cavity smearing liquid is smeared on the teeth, and long-term care of healthy whitening of the teeth is achieved.

Description

Anti-allergy whitening oral cavity smearing liquid

Technical Field

The invention relates to the technical field of oral care, in particular to a tooth whitening and anti-allergy technology, and specifically relates to an anti-allergy whitening oral cavity smearing liquid.

Background

The people always pursue a fashion to whiten and beautify the teeth. Today, the people advocate the beauty of laughing and laughing, and the brightness of teeth becomes a mark for measuring the beauty in the international fashion world. However, staining of the tooth surface greatly affects the aesthetic appearance thereof for various reasons. Various techniques for whitening teeth have been developed.

Patent CN101040828 discloses a tooth whitening agent and a preparation method thereof. The technology is characterized in that the prepared tooth whitening agent is filled in a special tooth washing rod body, one end of the rod body is wound with a layer of cotton balls, when the tooth whitening agent is used, the designated part of a plastic tube is broken, the tooth whitening agent flows to the cotton balls, and the cotton balls are used for scrubbing teeth so as to achieve the functions of cleaning teeth and whitening teeth; however, this method only provides a short scrubbing cleaning effect, and the time for the whitening component to act is limited.

Patent CN101141945A discloses a tooth whitening agent using glyceryl monooleate, which is solidified by moisture such as saliva after being applied to teeth, and thus can be adhered and fixed to teeth to achieve the effect of whitening teeth. However, although the method solves the inconvenience of using the household whitening suit, the problem of sensitivity of peroxide components to teeth is not considered; hundreds of clinical studies abroad have shown that the use of peroxide-containing products increases the sensitivity of teeth.

Dentine hypersensitivity is a common disease and a frequently encountered disease of stomatology, and is also one of the common causes of clinical toothache. At present, plugging dentinal tubules to reduce the permeability of dentin to reduce the flow of fluid within dentin is the fundamental approach to treating dentin hypersensitivity.

Patent CN102223921B discloses an oral care composition comprising a fused silica abrasive, wherein the fused silica has a median particle size of from about 0.25 microns to about 5.0 microns; however, the oral care composition achieves sensitivity protection only by blocking the dental tubules, but cannot rapidly relieve pain caused by sensitivity.

The prior published technology is combined, the whitening components are continuously innovated, and the technology is diversified. However, there are three general ways of tooth whitening: firstly, the doctor visits the office of the dentist to clean the teeth by a professional method, the curative effect is remarkable, but the method is expensive, long in time and incapable of operating by himself; the second method, which uses a home whitening kit using a bleaching agent such as peroxide and bleaching in a mouth guard, is a method that can be operated at home, but requires an auxiliary tool such as a mouth guard due to the gel-like property of the whitening agent, which has many safety problems in the oral cavity, and further, since the peroxide must be used at a high concentration and the tray makes physical stimulation to the teeth, and is liable to cause a sticky feeling and discomfort, which affects the daily life; the third approach, the use of whitening toothpastes, which require a constant use in the morning and evening over a relatively long period of time, is also not very effective. The whitening agent commonly used in the above ways is peroxide, and the currently disclosed technical method excessively pursues the whitening effect of the product, but ignores the risk of the whitening component increasing the sensitivity of teeth

For the symptom of tooth sensitivity, the current sensitivity protection mode of a consumer can be relatively single, even if the sensitivity protection toothpaste is used, the method needs to be used continuously every morning and evening for a long time, and the effect is not ideal. In the market, a plurality of desensitizing pastes are also available, the desensitizing paste is applied to teeth, but when the desensitizing paste is directly applied to the teeth, the desensitizing ingredients are quickly lost due to dilution of saliva, and the discomfort of tooth surface viscosity is caused. Most anti-allergy toothpastes today are used for both brushing and application, but the abrasive and surfactant components required for brushing are not needed for application and can cause irritation to the oral cavity during application. Therefore, the development of a new sensitive protection product in a new use mode is urgently needed, unnecessary stimulus sources are reduced, and the pain of sensitive teeth is relieved from the source.

In summary, whitening products employ harsh chemicals that cause pain or exacerbate tooth sensitivity, which is a particular problem for people with sensitive teeth. As for the toothpaste products on the market, the whitening problem is generally solved in a targeted manner or the sensitivity problem is solved in a targeted manner, so that the oral care product which is safe and effective and has the double effects of anti-allergy function and whitening function is researched and developed, the requirements of consumers are met, and the wide market space and the economic value are realized.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides the oral cavity smearing liquid which does not contain abrasive materials and surfactants, can continuously release anti-sensitivity components, relieve sensitivity pain, whiten teeth and is simple and convenient to operate.

The above object of the present invention is achieved by the following scheme:

an anti-allergy whitening oral cavity smearing liquid, which comprises the following components in part by weight:

the percentage is that the components account for the total weight of the oral smearing liquid formula.

The anti-allergy whitening oral cavity coating liquid preferably comprises the following components in percentage by weight:

in the formula, the whitening agent is any one of sodium phytate, hydrogen peroxide, percarbonate, percarbamide, pyrophosphate, metaphosphate or tripolyphosphate, and sodium phytate is preferred; the whitening agent of the invention achieves the purposes of preventing pigment from attaching, complexing, disintegrating and removing tooth stains through chemical action.

The hydrogen peroxide has a good whitening effect, but is easy to cause tooth sensitivity, the prior art has the defect that only the hydrogen peroxide is used for realizing the whitening effect and the tooth sensitivity problem is neglected, and the invention simultaneously uses the sensitivity-protecting agent in a compounding manner on the basis to make up for the defect. Therefore, hydrogen oxide can be selected as the whitening agent of the invention, but the whitening agent is preferably sodium phytate and is compounded with a sensitivity-protecting agent.

In the formula, the anti-allergy agent is any one or the combination of two or more than two of dipotassium glycyrrhizinate, potassium fluoride, potassium nitrate, potassium chloride, strontium acetate, hydroxyapatite or paeonol in any proportion; the anti-sensitivity agent of the invention prevents or treats dentin hypersensitivity by inhibiting nerve impulse or being capable of closing dentin microcystis or reducing permeability thereof; the anti-allergic agent of the invention suggests a combined synergistic effect, which acts from two directions of blocking and relieving; preferably a combination of potassium nitrate and strontium chloride, or a combination of potassium nitrate and hydroxyapatite; further preferred is a combination of potassium nitrate and hydroxyapatite at a weight ratio of 1: 1.

In the formula, the covering agent is any one of pearl powder, titanium dioxide or zinc oxide, preferably titanium dioxide; the covering agent can be uniformly spread on the surface of teeth to present a bright and white effect.

In the formula, the film-forming agent is any one of acrylic acid copolymer, shellac or paraffin, preferably shellac; the film forming agent can be dissolved in a solvent carrier, and can form a bright film-shaped substance when being applied to teeth.

In the above formula, the solvent is a carrier substance for helping the film-forming agent to quickly form a film, and the solvent is any one of sorbitol, glycerol, propylene glycol, polyethylene glycol or absolute ethyl alcohol, and preferably the combination of the absolute ethyl alcohol and the polyethylene glycol.

In the formula, the preservative is any one of sodium benzoate, methyl paraben or ethyl paraben, and sodium benzoate is preferred.

In the formula, the buffer stabilizer is any one of sodium pyrophosphate, sodium hexametaphosphate, sodium tripolyphosphate, potassium sodium tripolyphosphate or ethylene diamine tetraacetate, and sodium pyrophosphate is preferred; the buffering stabilizer of the invention is used for ensuring that the pH range of the whole product is close to the neutral environment of the oral cavity and meets the national standard, and because too high or too low pH can cause tooth stimulation and corrosion, the anti-allergy and whitening effects are affected. The prior art does not have a smearing type product which can resist allergy and whiten skin simultaneously. Therefore, the invention innovatively takes anti-allergy and whitening components into consideration at the same time, and can realize two effects of whitening and anti-allergy.

In the formula, the flavoring agent is any one of saccharin sodium, sucralose, sodium chloride or essence.

The whitening component contained in the oral cavity smearing liquid is continuously released on the tooth surface to oxidize tooth stain pigment substances, so that the effect of chemically whitening the teeth is achieved; the contained anti-sensitive ingredients block the exposed dentinal tubules on the tooth surface, and the anti-sensitive ingredients which are continuously released relieve sensitive pain, and the oral cavity smearing liquid can realize the long-term effective whitening and anti-sensitive double effects by directly smearing on the teeth without any tool, thereby protecting the healthy whitening of the teeth.

Compared with the prior art, the invention has the following beneficial effects:

1. the anti-allergy whitening oral cavity smearing liquid does not contain an abrasive, a thickening agent and a surfactant;

2. the anti-allergy whitening oral cavity smearing liquid can comprehensively whiten teeth from two aspects of physics and chemistry; physically, the oral cavity smearing liquid contains whitening pigment which is uniformly spread along with the film, so that the teeth can be glossy and white, and the effect of instantly beautifying the teeth is achieved; chemically, the whitening component contained in the oral cavity smearing liquid is continuously released on the tooth surface, and the tooth stain pigment substances are oxidized and decomposed to whiten the teeth; meanwhile, the coating can isolate the invasion of the food-intake substance to the teeth, protect the teeth and slow down the exogenous staining of the teeth;

3. the anti-sensitivity whitening oral cavity smearing liquid can effectively relieve tooth sensitivity symptoms and can weaken the irritation influence brought by whitening components;

4. the anti-allergy whitening oral cavity smearing liquid adopts the reasonable matching of the film forming agent and the solvent, so that the anti-allergy whitening oral cavity smearing liquid can be directly smeared on teeth, can quickly form a film on dry tooth surfaces, and can keep the film close to the tooth surfaces without falling off and dissolving even under the condition of chewing movement;

5. the anti-allergy whitening oral cavity smearing liquid can be removed by brushing without using a mouth gag tool or banning eating, is simple and convenient to operate, can be automatically operated at home, and can not generate foreign body feeling and sticky feeling when being smeared on teeth.

The main factors for implementing the invention include: factor 1 is the carrier of the product: the film forming agent and the solvent are matched, so that a film can be coated on teeth, the film can be rapidly formed on dry tooth surfaces, the film is tightly attached to the tooth surfaces, and the film can be kept not to fall off and be dissolved even under the condition of chewing movement. Factor 2 is the functional component of the product: firstly, the combination of the effects, whitening and anti-allergy, provides whitening and simultaneously achieves the anti-allergy effect, and secondly, the combination of the anti-allergy agents, preferably the combination of two anti-allergy agents, achieves the anti-allergy effect through two ways of outburst from another species.

Detailed Description

The present invention will be further described below by way of examples and comparative examples, but the present invention is not limited to the following examples.

Examples 1, 2, 3 and 4 are anti-sensitivity whitening oral application liquids of the present invention, and comparative examples 1, 2, 3 and 4 are comparative experimental groups; the formulations of examples 1 to 4 and comparative examples 1 to 4 are shown in Table 1.

TABLE 1 formulation of examples and comparative examples

The above percentages are the percentage of each component of the formula in the total weight of the formula.

The preparation method of the oral smearing liquid comprises the following steps:

step 1

Dissolving sodium phytate, potassium nitrate, strontium chloride, sodium pyrophosphate and saccharin sodium by using deionized water, and stirring and dissolving to prepare an aqueous phase solution;

step 2

Adding polyethylene glycol and a proper amount of absolute ethyl alcohol into the aqueous phase solution obtained in the step (1), stirring, then adding titanium dioxide, hydroxyapatite and sodium carboxymethylcellulose, and stirring until a uniform dispersion liquid is obtained; the proper amount of absolute ethyl alcohol is 30 percent of the formula amount of the absolute ethyl alcohol;

step 3

Adding the shellac into the balance of the absolute ethyl alcohol under stirring, stirring for 120 minutes until the solution is cool lemon, stopping stirring, adding the dispersion liquid prepared in the step 2 into the solution, and stirring for 30 minutes to prepare the required oral cavity smearing liquid; the balance of the absolute ethyl alcohol is 70 percent of the formula amount of the absolute ethyl alcohol.

Example 5 verification of whitening Effect

The oral coating liquids of example 1, example 2, example 3, example 4, comparative example 1 and comparative example 3 were subjected to skin whitening effect verification by the following method:

1. enamel blocks with uniform staining and L values between 30 and 45 were selected and randomly divided into 6 groups (4 groups of examples and 2 groups of comparative examples) based on L, so that the sum of L values between each group was approximately the same.

2. Enamel color was measured for each group using an X-Rite SP 64 colorimeter and L values were recorded, labeled L pre.

3. And (3) directly and uniformly coating a layer of oral cavity coating liquid on the black stained bovine tooth enamel by adopting the coating liquid required to be tested, standing at normal temperature for 30min, washing the coating liquid on the bovine teeth with water, sucking water with a paper towel, and airing in the air for 5 min.

4. The color of brushed enamel was measured using an X-Rite SP 64 colorimeter and the L value, labeled L post, was recorded.

5. The larger the △ L, △ L value of each group was calculated, the better the surface whitening effect.

The results of the whitening verification effect are shown in table 2.

Table 2: the whitening results of examples 1 to 4 and comparative examples 1 and 3 were verified:

comparative example 1 and examples 1-4 were compared without the addition of a whitening agent; comparative example 3 is compared to examples 1-4 without the addition of a masking agent; as can be seen from the results of table 2, the whitening effects of comparative example 1 and comparative example 3, which do not contain a whitening agent, are weaker than those of the examples, thus demonstrating that the addition of a masking agent has a significant physical brightening effect on teeth, while the addition of a whitening agent plays a critical role in the whitening effect.

Example 6 verification of anti-allergic Effect

The oral coating liquids of example 1, example 2, example 3, example 4 and comparative example 2 were subjected to verification of anti-sensitivity effect by the following methods:

1. preparing a dentin sample: fresh extracted bovine incisors are cut and polished to prepare 25 dentin blocks with the size of about 5mm multiplied by 2mm, and the dentin blocks are subjected to acid etching and demineralization treatment and observed under a polarized light microscope to ensure that the dental tubules are fully exposed.

25 dentin samples were randomly assigned to 5 groups of 5 oral spread preparations prepared according to the formulations of comparative example 2 and examples 1-4, 5 blocks each.

2. Partitioning: one half of the area (about 5 mm. times.2.5 mm) of the dentin sample was taped as a non-treated area, and the other half (about 5 mm. times.2.5 mm) was used as an experimental treated area to which the coating solution was applied.

3. Coating treatment: the smearing liquid required to be tested is directly and uniformly coated with a layer of oral smearing liquid in the experimental treatment area for each group, and the oral smearing liquid is placed at normal temperature for 30 min. The smearing liquid on the bovine teeth is washed with water within 30min, and then is dried in a paper towel for 5 min. The treatment was repeated 7 times.

4. Observation by a scanning electron microscope: observing the dried dentin sample under a scanning electron microscope, respectively taking three visual field pictures in a treatment area and a non-treatment area, counting exposed tubules C, and finally calculating the average value.

5. Calculating the occlusion rate R of the dental tubules of each group:

R(％)＝(∑_{non-treatment zone C}-∑_{Treatment zone C})/∑_{Non-treatment zone C}×100

The results are shown in Table 3.

Table 3: plugging rates of comparative example 2 and examples 1-4

	Example 1	Example 2	Example 3	Example 4	Comparative example 2
						The plugging rate R mean value%	65	69	53	66	5

As can be seen from the results in Table 3, the blocking rate of the product without the added sensitivity-protecting agent is very low and can be ignored. The plugging effect of example 3 is lower than that of the other examples, showing that the plugging effect of the sensitivity-protecting agent in example 3 is slightly weaker than that of the sensitivity-protecting agents in the other examples.

Example 7

Compared with the embodiment, the sodium carboxymethylcellulose colloid system is adopted to replace a shellac system so as to investigate the use performance of the coating liquid.

The investigation indexes are as follows:

convenience in painting: when the liquid is smeared on the surface of teeth, whether the film is easy to spread evenly or not is judged;

film forming property: after the coating is finished, keeping the mouth open for 1min to determine whether a film can be formed;

comfort: after the coating is finished, whether foreign body feeling, discomfort and viscous feeling exist in the oral cavity or not;

stability: after the smearing operation is finished, whether the smearing liquid is dissolved or not or in which time period the smearing liquid starts to be dissolved or not can be defined as stable if the phenomenon of dissolution does not occur after 4 hours.

TABLE 4 investigation of the use Properties of comparative example 4 and examples 1 to 4

Survey index	Example 1	Example 2	Example 3	Example 4	Comparative example 4
						Convenience of painting	Good effect	Good effect	Good effect	Good effect	Good effect
Film forming property	Formable film	Formable film	Formable film	Formable film	Rough film shape
						Comfort feeling	Comfort of the wearer	Comfort of the wearer	Comfort of the wearer	Comfort of the wearer	Sticky feeling
Stability of	Stabilization	Stabilization	Stabilization	Stabilization	Gradually dissolve

According to the results in table 4, it can be seen that the shellac system used in the oral cavity liniment disclosed by the present invention can form a film rapidly, and the formed film is smooth and comfortable and exists stably in the oral cavity environment. Compared with other disclosed inventions which adopt a glue system, the shellac system is more stable as a carrier of components such as sensitivity protection, whitening and the like.

Variations and modifications to the above-described embodiments may occur to those skilled in the art, which fall within the scope and spirit of the above description. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and some modifications and variations of the present invention should fall within the scope of the claims of the present invention. Furthermore, although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.

Claims

1. The anti-allergy whitening oral cavity smearing liquid is characterized in that the formula of the oral cavity smearing liquid is composed of the following components:

the balance of deionized water;

the percentage is that each component accounts for the total weight of the oral cavity smearing liquid formula;

the whitening agent is sodium phytate;

the anti-allergic agent is a combination of potassium nitrate and hydroxyapatite in a weight ratio of 1: 1.

2. The anti-sensitivity whitening oral spread liquid according to claim 1, characterized in that the preferred formulation of the oral spread liquid consists of the following components:

the balance of deionized water;

3. The anti-allergy whitening oral cavity coating liquid according to claim 1 or 2, wherein the covering agent is pearl powder, titanium dioxide or zinc oxide, the film forming agent is acrylic acid copolymer, shellac or paraffin, the solvent is one or a combination of two of sorbitol, glycerin, propylene glycol, polyethylene glycol or absolute ethyl alcohol in any proportion, the preservative is sodium benzoate, methyl paraben or ethyl paraben, the buffer stabilizer is sodium pyrophosphate, sodium hexametaphosphate, sodium tripolyphosphate, sodium potassium tripolyphosphate or ethylene diamine tetraacetate, and the flavoring agent is saccharin sodium, sucralose, sodium chloride or essence.

4. The anti-sensitivity whitening oral liquid according to claim 3, characterized in that the covering agent is titanium dioxide, the film forming agent is shellac, the solvent is a combination of absolute ethanol and polyethylene glycol, the preservative is sodium benzoate, and the buffer stabilizer is sodium pyrophosphate.