JP6432307B2 - Aqueous gel composition for tooth surface application - Google Patents

Description

  The present invention provides an aqueous gel for tooth surface application that is applied to teeth and gives a high medicinal component retention effect and retention feeling (tooth surface coating feeling) and is suitable for prevention or suppression of oral diseases such as caries. Relates to the composition.

  Traditionally, toothpaste and gargle have been used primarily for cleaning the oral cavity, but recent dentifrices and mouthwashes contain medicinal ingredients, and toothpaste and mouthwash behaviors with dentifrices. In many cases, a medicinal component is dispersed in the oral cavity to prevent or suppress oral disease. However, in brushing brushes, brushing is done for a relatively long time for cleaning purposes, and diluted with saliva, or multiple water rinses are performed to eliminate the residual feeling of the preparation and foam. Many are discharged. In addition, the mouthwash usually has a low viscosity in order to improve the feeling of use. For this reason, there is a problem in the retention of the medicinal component, and there is still room for improvement in the effect.

  On the other hand, there is an oral ointment as an agent that retains functional components in the oral cavity, which is intended for local use on the affected area. Etc.) and are usually not suitable.

  As a retention technique of the functional component in the composition for oral cavity, a method such as adsorption by anion-cation complex formation (Patent Document 1; JP 2007-320894A) or removal of a retention inhibitor component, increasing the formulation viscosity, etc. There is a method of physically leaving it (Patent Document 2; JP 2009-96747 A). In the case of dentifrice, it is possible to increase the residual amount in the oral cavity by reducing the number of water rinses after use.

  However, these are technologies related to a general dentifrice composition, but the method of forming a composite can exhibit the effect derived from the functional component to some extent, but cannot obtain a feeling of staying, and is continuously used. It was not connected to. In addition, the method of increasing the formulation viscosity and stickiness in order to leave the components physically is difficult to use in actual use because the formulation feels worse and the number of rinses increases. Furthermore, simply reducing the number of rinses after brushing to increase the residual amount of dentifrice in the oral cavity will leave bubbles in the mouth, causing discomfort, and is unsuitable for actual use. The problem of retention due to dilution with saliva remains.

JP 2007-320894 A JP 2009-96747 A

  Therefore, it has been desired to develop a new technique for improving the oral retention of functional components such as medicinal components in oral preparations and providing preparations suitable for practical use effective in preventing or suppressing oral diseases.

  The present invention has been made in view of the above circumstances, and when applied to teeth, gives a high medicinal ingredient retention effect and retention feeling (tooth surface coating feeling) to prevent or suppress oral diseases such as caries. An object of the present invention is to provide a water-based gel composition for application to a tooth surface.

  As a result of intensive studies to achieve the above object, the present inventors have found that (A) polyoxyethylene hydrogenated castor oil, (B) thickening silica having a liquid absorption of 3.5 mL / g or more, (C) poly When the aqueous gel composition containing sodium acrylate and (D) medicinal component is applied to the teeth, it gives a high medicinal component retention effect and a retention effect (tooth surface coating effect), and also a foam residue and preparation. It has been found that the residual feeling of the mouth is suppressed and the feel in the oral cavity is good, and it is suitable for the prevention or suppression of oral diseases such as caries, and the present invention has been made.

  That is, in the present invention, the aqueous gel composition is combined with (A) polyoxyethylene hydrogenated castor oil, (B) thickening silica having a high liquid absorption amount of 3.5 mL / g or more, and (C) poly When a combination system with sodium acrylate is blended, the components (A), (B), and (C) act specifically, and the retention of the (D) medicinal component contained in the aqueous gel composition on the tooth surface is An improved and satisfactory tooth surface coat feeling can be imparted. In this case, the aqueous gel composition of the present invention is not used for brushing teeth as shown in the examples below, but it is used by applying to the tooth surface, and after application, the mouth is lightly rinsed with water, (A), (B), (C) Compared with a control product that does not contain components, the retention amount of medicinal components such as fluorine ions in hydroxyapatite is 1.1 times or more, and the tooth surface retention is high. It is possible to remarkably improve the retention of the ingredients in the oral cavity, and at the same time, it gives an excellent retention feeling that the tooth surface is sufficiently coated, and also applies water gel to the tooth surface after being applied and rinsed with water Even if the composition remains, there is little unpleasant residual feeling such as foam residue and stickiness of the preparation, giving a good feel in the oral cavity, which is suitable for use. Therefore, the effect of the medicinal component is sufficiently exhibited, and oral diseases such as caries can be effectively prevented or suppressed.

  Furthermore, the aqueous gel composition for tooth surface application | coating of this invention is 3-30 as mass ratio (B) / (C) which shows the ratio of content of (B) component and (C) component, When the component (D) is preferably a fluoride, the above effect is more excellent.

  In Patent Document 2, a dentifrice composition containing no abrasive contains polyoxyethylene hydrogenated castor oil together with isopropylmethylphenol and a thickening silica having a liquid absorption amount of 3.5 mL / g or more. Achieved the problems related to the incorporation of isopropylmethylphenol into the product, and improved the storage stability of isopropylmethylphenol, and also reduced the dispersibility by suppressing the dissolution of the dentifrice composition in water to the gums. This improves the staying property. That is, Patent Document 2 is an invention of a dentifrice effective for periodontal diseases, and there is no mention of the tooth surface application agent of the present invention. Moreover, the dentifrice composition disclosed in Patent Document 2 is inferior to the present invention in the retention of components due to use on the tooth surface.

Accordingly, the present invention provides the following aqueous gel composition for tooth surface application.
[1]
(A) 0.5-6 mass% of polyoxyethylene hydrogenated castor oil whose average added mole number of ethylene oxide is 20-100 ,
(B) thickening silicas liquid suction amount 3.5 ~5 mL / g 0.5~8 wt%,
(C) Sodium polyacrylate 0.1-1 mass%
And (D) a water-based gel composition for tooth surface application comprising a medicinal component (however, the liquid absorption is expressed as the liquid absorption (mL) per 1 g of thickening silica) Calculated by
A sample (1.0 g) was weighed on a clean glass plate, and the sample was mixed with a stainless spatula while adding 42.5% by mass of glycerin little by little using a microburette. When the sample became one lump and came to peel off from the glass plate with a spatula, the end point was set, and the required liquid volume (mL) was set as the liquid absorption volume. )
[2]
(B) / (C) which shows the ratio of content of (B) component and (C) component is 3-30 as a mass ratio, The aqueous gel composition for tooth surface application | coating of [1] description.
[3]
(D) The aqueous gel composition for tooth surface application according to [1] or [2], wherein the component is fluoride.
[4]
The aqueous gel composition for tooth surface application according to [3], wherein the content of the component (D) is 100 to 3,000 ppm as fluorine.
[5]
Further, the tooth surface application according to any one of [1] to [4], wherein the anionic surfactant and the amphoteric surfactant are not contained or when these are contained, the content is 0.5% by mass or less. Aqueous gel composition.
[6]
The aqueous gel composition for tooth surface application according to any one of [1] to [5], further comprising (B ′) 0.5 to 6 mass% of thickening silica having a liquid absorption amount of less than 3.5 mL / g. object.
[7]
The aqueous gel composition for tooth surface application according to any one of [1] to [6], which is used for rinsing the oral cavity with water after application to teeth.
[8]
The aqueous gel composition for tooth surface application according to any one of [1] to [7], which is for use before going to bed.

  According to the present invention, by applying it to teeth, it gives a high medicinal component retention effect and a retention feeling (tooth surface coating feeling), and an unpleasant residual feeling is suppressed and the feeling in the oral cavity is good. Yes, an aqueous gel composition for tooth surface application suitable for prevention or suppression of oral diseases such as caries can be provided.

  The present invention will be described in further detail below. The aqueous gel composition for tooth surface application of the present invention comprises (A) polyoxyethylene hydrogenated castor oil, (B) thickening silica having a liquid absorption of 3.5 mL / g or more, (C) sodium polyacrylate, and ( D) It contains a medicinal component.

  (A) As polyoxyethylene hydrogenated castor oil, those having an average added mole number of ethylene oxide (EO) of 20 to 100 can be used, and those having 20 to 60 are particularly preferable. E. O. It is preferable that the average added mole number of is within the above range to sufficiently provide the retention effect and retention feeling of the medicinal component.

  The blending amount of the polyoxyethylene hydrogenated castor oil as the component (A) is preferably 0.5 to 6% (mass%, the same shall apply hereinafter) of the whole composition, more preferably 1 to 5%, particularly preferably 1. 5 to 5%. The greater the amount, the better the retention effect. When 0.5% or more is added, the retention effect can be sufficiently imparted, and the remaining feeling of foam is sufficiently suppressed, and the mouth feel after rinsing is reduced. And the applicability of the composition is improved. A blending amount of 6% or less is suitable for suppressing a decrease in staying feeling.

(B) Thickening silica has a liquid absorption of 3.5 mL / g or more, preferably 3.5 to 5 mL / g. If the liquid absorption amount is less than 3.5 mL / g, the retention effect and the retention feeling of the medicinal component cannot be imparted. Moreover, it is suitable that it is 5 mL / g or less in order to suppress a stay actual feeling weakening and to prevent the stability reduction of a formulation.
In the present invention, among the thickening silicas that generally have a wide range of liquid absorption amounts, in particular, (B) the use of thickening silica having a high liquid absorption amount that is equal to or higher than the above value, An effect can be given.
The liquid absorption amount of the thickening silica can be calculated as a liquid absorption amount (mL) per 1 g of the thickening silica, for example, by the measurement method described in Examples described later (hereinafter the same).

  (B) 0.5-8% of the whole composition is preferable, and, as for the compounding quantity of the thickening silica of a component, More preferably, it is 1-6%, Most preferably, it is 2-5%. The greater the blending amount, the better the retention effect and the retention feeling imparting effect. When the amount is 0.5% or more, the retention effect and the retention feeling can be sufficiently imparted, and when it is 8% or less, the retention feeling is lowered. Therefore, it is suitable for preventing the deterioration of the formulation stability.

In the present invention, in addition to (B) thickening silica having a liquid absorption amount of 3.5 mL / g or more, (B ′) the liquid absorption amount is less than 3.5 mL / g, particularly 3.0 mL / g or less, particularly 2. Thickening silica of 0 mL / g or less can be used, and the liquid absorption amount is desirably 1.0 mL / g or more. When the component (B ′) is used in combination, the ease of application to the teeth and the ease of spreading the formulation are improved.
In addition, when mix | blending the thickening silica of (B ') component, the compounding quantity is 6% or less of the whole composition, 0.5 to 4% is preferable especially, It mix | blends within the range of the compounding quantity of (B) component. Can do.

  (C) Sodium polyacrylate is not particularly limited as long as it can be used for oral preparations, and examples thereof include those having a molecular weight of about 1 to 8 million. Either a non-crosslinked type or a crosslinked type can be used, but the crosslinked type is more preferable. Examples of commercially available products include Rheosic 260H (cross-linked type) and Aron A-20P manufactured by Toagosei Co., Ltd. 0.1 to 1% of the whole composition is preferable, and, as for the compounding quantity of sodium polyacrylate, More preferably, it is 0.3 to 1%. The retention effect and the retention feeling are improved as the blending amount is increased. When the content is 0.1% or more, the retention effect and the retention feeling can be sufficiently imparted, and when it is 1% or less, the retention feeling is lowered. It is suitable for suppressing the above.

In the present invention, the combined use of the component (B) and the component (C) can provide a medicinal component retention effect and a retention feeling imparting effect. In this case, the components (B) and (C) are appropriately used. When combined in proportion, a better effect can be imparted.
In this case, (B) / (C) indicating the ratio of the content of the component (B) to the content of the component (C) is preferably 3 to 30, more preferably 5 to 30, and still more preferably. 5-20. When (B) / (C) is within the above range, the retention effect and retention effect imparting effect are further improved, and the residual feeling of the foam and the agent after rinsing can be suppressed and the mouth feel can be better maintained. .

(D) As the medicinal component, a medicinal component generally used in oral preparations can be used.
Specific examples include fluorides such as sodium fluoride, sodium monofluorophosphate, tin fluoride, and amine fluoride, water-soluble calcium sources such as calcium glycerophosphate, and whitening ingredients such as polyphosphates. May be used alone or in combination of two or more.
Among them, fluoride is most likely to flow away due to rinsing and is difficult to stay on the tooth surface in toothpaste. When used, the retention of such fluoride on the tooth surface in the oral cavity is improved, and the caries prevention or suppression effect derived therefrom can be enhanced.

(D) The compounding quantity of the medicinal component of a component is an effective amount which gives the medicinal effect according to the kind of component, and can be adjusted suitably.
When using fluoride, the compounding quantity is preferably within a range of 100 to 3,000 ppm, particularly 100 to 1,500 ppm as fluorine. For example, sodium fluoride is preferably blended in the range of 0.02 to 0.66% of the total composition, and sodium monofluorophosphate is blended in the range of 0.05 to 2.3% of the total composition. Specifically, when 0.21% of sodium fluoride is blended, the fluorine content corresponds to 950 ppm.
When the amount is within the above range, the retention effect on the teeth and the retention feeling can be sufficiently imparted, and the feel in the oral cavity can be sufficiently satisfactorily maintained.

  In the aqueous gel composition for tooth surface application of the present invention, if necessary, a known component other than the above components that can be blended in the oral preparation can be blended as long as the effects of the present invention are not hindered. Specific examples include a binder other than thickening silica, a surfactant other than polyoxyethylene hydrogenated castor oil, a thickener, a sweetener, a preservative, and a fragrance. In addition, it is not necessary to contain an abrasive.

  Examples of the binder include gums such as xanthan gum, and cellulose derivatives such as hydroxyethyl cellulose and cationized cellulose. The amount of these binders is preferably 0.2 to 5%.

As the surfactant, a nonionic surfactant effective for improving the coating property is suitable, and as the nonionic surfactant, sugar fatty acid ester such as sucrose fatty acid ester, sugar alcohol fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester , Polyglycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, fatty acid alkanolamide and the like. When blending these nonionic surfactants, the blending amount is preferably 0.2 to 5%.
Moreover, you may add cationic surfactants, such as benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride which have a bactericidal effect, and the compounding quantity is 0.001-0.2%.
Furthermore, an anionic surfactant such as N-acyl sarcosinate such as sodium N-lauroyl sarcosine, N-acyl glutamate, sodium α-olefin sulfonate, betaine, etc., as long as the effects of the present invention are not hindered. Although amphoteric surfactants and cationic surfactants such as alkylammonium surfactants may be added, anionic surfactants and amphoteric surfactants are compositions in terms of suppressing unpleasant residual feeling such as foam residue. It is preferable not to be included in the product, and when it is included, the total content is preferably 0.5% or less, more preferably 0.3% or less, and particularly preferably 0.1% or less.

Examples of the thickener include sugar alcohols such as sorbit, polyhydric alcohols such as propylene glycol, and the blending amount is usually 10 to 60%.
Examples of the sweetening agent include saccharin sodium, and examples of the preservative include paraoxybenzoic acid ester, benzoic acid or a salt thereof.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, bran oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumed, menthol, moss Bonn, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-Mentoxypropane-1,2-diol, Thymol, Linalol, Linarel acetate, Limonene, Menthone, Menthyl acetate, N-Substituted paramenthane 3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl thiol Used for oral preparations such as acetate flavors, strawberry flavors, apple flavors, banana flavors, pineapple flavors, grape flavors, mango flavors, butter flavors, milk flavors, fruit mix flavors, tropical fruit flavors, etc. The known perfume materials can be used in combination. It is not limited to the fragrance | flavor of an Example description. Moreover, although a compounding quantity is not specifically limited, As for said fragrance | flavor raw material, 0.000001 to 1% of the whole composition is preferable. Moreover, as a fragrance | flavor for fragrance | flavor which uses the said fragrance | flavor raw material, it is preferable to use 0.1 to 2% of the whole composition.

  The aqueous gel composition for application to the tooth surface of the present invention is not used by brushing the teeth for several minutes and brushing the teeth for several minutes, and then rinsing with water several times like a general dentifrice. It can be applied and used, and it can be suitably used by lightly rinsing the oral cavity with water after applying it so as to spread over a part or the whole of the dentition. In this case, it is preferable to rinse the oral cavity to the extent that the aqueous gel composition remains moderately on the tooth surface after application, and the number of rinses after application may be 2 times or less, preferably 1 time, about 10 to 20 mL. Just put water in your mouth and go light for about 1-3 seconds. The composition of the present invention is easy to rinse because it has little foam residue and stickiness, and is suitable for a small amount of mouthwash, and even when rinsed once, the residual feeling of foam in the oral cavity and the sticky feeling of the preparation are suppressed. While the feeling is good, the coat feeling is high and the effect feeling is excellent, and in fact, the retention of the medicinal component is high. The aqueous gel composition remaining on the tooth surface is gradually dissolved in the oral cavity by saliva and disappears.

Application to the tooth surface is not particularly limited, and the aqueous gel composition may be applied on a finger or an application tool may be used. As an application tool, a toothbrush, cloth, non-woven fabric, paper, sponge, silicone, brushes such as nylon and wool, and a cotton swab can be used. In order to apply evenly over the entire tooth surface, it is preferable in terms of operability to apply it so that it is spread over the tooth surface using a toothbrush.
The amount of aqueous gel composition used is not particularly limited as long as it is an amount that can be applied to the tooth surface, and can be adjusted as appropriate. In order to cover the whole, it is desirable to use about 0.1 to 1.5 g, preferably about 0.3 to 1.2 g per time.

  The aqueous gel composition of the present invention is preferably used after brushing with a dentifrice or gargle with a mouthwash, and more preferably used before going to bed. Since the oral cavity after going to bed becomes an environment where oral diseases such as caries are likely to progress due to a decrease in the amount of saliva, if used before going to bed, it is effective for prevention or suppression of oral diseases such as caries. Within 1 hour is preferable, within 30 minutes is more preferable, and within 15 minutes is particularly preferable.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
The aqueous gel composition for tooth surface application | coating of the composition shown to Tables 1-3 was prepared by the conventional method, and the following method evaluated. The results are shown in the table. The liquid absorption amount of the thickening silica was measured by the following method.

Measuring method of liquid absorption amount;
A sample (1.0 g) was weighed on a clean glass plate, and the sample was mixed with a stainless spatula while adding 42.5% glycerin dropwise little by little using a microburette. When the sample became one lump and came to peel off from the glass plate with a spatula, the end point was set, and the required liquid volume (mL) was set as the liquid absorption volume.

(1) Method for evaluating medicinal component retention effect (fluorine retention effect) The prepared aqueous gel composition was diluted 3-fold with purified water and centrifuged at 3,000 rpm for 10 minutes to obtain a supernatant solution of hydroxyapatite (HA) disc ( It was allowed to act for 3 minutes on a diameter Φ7 mm, a thickness 3.5 mm, manufactured by PENTAX, and immediately washed with purified water. After the HA disk is dried, the top surface of the HA disk is decalcified with acid for 2 minutes to extract fluoride ions, and the fluoride ion concentration contained in the solution is measured by a fluoride ion meter (Orion 1115000 4-Star: Thermo Fisher Scientific). Measured by Tiffic Co.).
About the average value of N = 6, it showed by (double-circle), (circle), (triangle | delta), and x according to the reference | standard shown below by comparison with a control product (following composition).

Control product composition (D) Sodium fluoride 0.21%
Thickening silica (Liquid absorption amount 2mL / g) 4.5
Sorbit liquid (70%) 55
Propylene glycol 5
Xanthan gum 1.3
Saccharin sodium 0.1
Hydroxyethyl cellulose dimethyl diallylammonium chloride
0.05
Water balance
Total 100.0%

Evaluation criteria for fluorine retention effect;
◎: The amount of fluoride ions in the extract was significantly higher than that of the control product, and the average value was 1.5 times or more. ○: The amount of fluoride ions in the extract was significantly higher than that of the control product. The average value was 1.1 times or more and less than 1.5 times △: The amount of fluoride ion in the extract was not significantly different from the control product ×: Fluoride ion in the extract The amount was significantly lower than the control product

(2) Evaluation method of stay feeling (tooth surface coat feeling) The tooth coat feeling after using the aqueous gel composition by the following method was sensorially evaluated by six evaluators.
After taking 1 g of the composition on a toothbrush and spreading it so as to be applied to the entire tooth surface (application for 1 minute), the sensation after rinsing once for 1 to 3 seconds with 15 mL of water in the mouth was determined according to the following criteria. . Evaluation was performed based on the following evaluation criteria from the average of 6 persons.

Judgment criteria for tooth coat feeling;
5: Feeling that teeth are coated very much 4: Feeling that teeth are coated slightly feel 3: Feeling that teeth are coated slightly feel 2: Feeling that teeth are coated are not felt much 1: Tooth I don't feel the feeling of being coated at all;
◎: Average value is 4 or more and 5 or less ○: Average value is 3 or more and less than 4 points △: Average value is 2 or more and less than 3 points ×: Average value is 1 or more and less than 2 points

(3) Evaluation method of lack of residual feeling (feeling in mouth after rinsing) About the feeling in mouth after using the aqueous gel composition by the above method, 6 panelists who were evaluators determined based on the following criteria. Evaluation was performed based on the following criteria from the average of 6 persons.

Judgment criteria;
5: Feel no residual feeling of foam or agent 4: Feel little residual feeling of foam or agent 3: Feel slightly residual feeling of foam or agent 2: Feel a little residual feeling of foam or agent 1: Foam Evaluation criteria to feel the residual feeling
◎: Average value is 4 or more and 5 or less ○: Average value is 3 or more and less than 4 points △: Average value is 2 or more and less than 3 points ×: Average value is 1 or more and less than 2 points

Details of the raw materials used are shown below. In addition, the number in () of polyoxyethylene hydrogenated castor oil is the average added mole number of ethylene oxide.
(A) polyoxyethylene (POE) (20) hydrogenated castor oil;
Polyoxyethylene (20) hydrogenated castor oil (Aoki Yushi Co., Ltd.)
Polyoxyethylene (POE) (60) hydrogenated castor oil;
Polyoxyethylene (60) hydrogenated castor oil (Aoki Yushi Co., Ltd.)
Polyoxyethylene (POE) (100) hydrogenated castor oil;
Polyoxyethylene (100) hydrogenated castor oil (Aoki Yushi Co., Ltd.)
(B) Thickening silica (Liquid absorption amount 4 mL / g);
AEROSIL200 (manufactured by EVONIK)
Thickening silica (Liquid absorption 5 mL / g);
AEROSIL200 (manufactured by EVONIK)
(C) Sodium polyacrylate; Rheojic 260H (manufactured by Toagosei Co., Ltd.)
(D) Sodium fluoride; purified sodium fluoride (manufactured by Stella Chemifa Corporation)
Sodium monofluorophosphate;
Sodium monofluorophosphate (Rhodia Nikka Co., Ltd.)
Thickening silica (Liquid absorption amount 2mL / g); Carplex (Evonik)
Sodium carboxymethylcellulose (comparative product);
CMC Daicel (Daicel Finechem Co., Ltd.)

Claims (8)

(A) 0.5-6 mass% of polyoxyethylene hydrogenated castor oil whose average added mole number of ethylene oxide is 20-100 ,
(B) thickening silicas liquid suction amount 3.5 ~5 mL / g 0.5~8 wt%,
(C) Sodium polyacrylate 0.1-1 mass%
And (D) a water-based gel composition for tooth surface application comprising a medicinal component (however, the liquid absorption is expressed as the liquid absorption (mL) per 1 g of thickening silica) Calculated by
A sample (1.0 g) was weighed on a clean glass plate, and the sample was mixed with a stainless spatula while adding 42.5% by mass of glycerin little by little using a microburette. When the sample became one lump and came to peel off from the glass plate with a spatula, the end point was set, and the required liquid volume (mL) was set as the liquid absorption volume. )   (B) / (C) which shows the ratio of content of (B) component and (C) component is 3-30 as mass ratio, The aqueous gel composition for tooth surface application | coating of Claim 1 characterized by the above-mentioned.   The aqueous gel composition for tooth surface application according to claim 1 or 2, wherein the component (D) is a fluoride. The aqueous gel composition for tooth surface application according to claim 3, wherein the content of component (D) is 100 to 3,000 ppm as fluorine. Furthermore, when an anionic surfactant and an amphoteric surfactant do not contain or contain these, the content is 0.5% by mass or less, for tooth surface application according to any one of claims 1 to 4. Aqueous gel composition. The aqueous gel composition for tooth surface application according to any one of claims 1 to 5, further comprising (B ') 0.5 to 6 mass% of thickening silica having a liquid absorption amount of less than 3.5 mL / g. . The aqueous gel composition for tooth surface application according to any one of claims 1 to 6, which is for rinsing the oral cavity with water after application to teeth. The aqueous gel composition for tooth surface application according to any one of claims 1 to 7, which is for use before going to bed.