CN106937925A - A kind of compound traditional Chinese medicine composite and toothpaste containing the compound traditional Chinese medicine composite and preparation method thereof - Google Patents
A kind of compound traditional Chinese medicine composite and toothpaste containing the compound traditional Chinese medicine composite and preparation method thereof Download PDFInfo
- Publication number
- CN106937925A CN106937925A CN201710123121.9A CN201710123121A CN106937925A CN 106937925 A CN106937925 A CN 106937925A CN 201710123121 A CN201710123121 A CN 201710123121A CN 106937925 A CN106937925 A CN 106937925A
- Authority
- CN
- China
- Prior art keywords
- toothpaste
- parts
- extract
- herbal mixture
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000606 toothpaste Substances 0.000 title claims abstract description 86
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 86
- 239000003814 drug Substances 0.000 title claims abstract description 38
- 150000001875 compounds Chemical class 0.000 title claims abstract description 27
- 239000002131 composite material Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims description 17
- 239000000203 mixture Substances 0.000 claims abstract description 62
- 241000050051 Chelone glabra Species 0.000 claims abstract description 28
- 244000246386 Mentha pulegium Species 0.000 claims abstract description 28
- 235000016257 Mentha pulegium Nutrition 0.000 claims abstract description 28
- 235000004357 Mentha x piperita Nutrition 0.000 claims abstract description 28
- 235000001050 hortel pimenta Nutrition 0.000 claims abstract description 28
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 27
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 26
- 244000025254 Cannabis sativa Species 0.000 claims abstract description 26
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 240000001949 Taraxacum officinale Species 0.000 claims abstract description 5
- 239000000284 extract Substances 0.000 claims description 79
- 239000000463 material Substances 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 239000012535 impurity Substances 0.000 claims description 36
- 238000010992 reflux Methods 0.000 claims description 30
- 239000002904 solvent Substances 0.000 claims description 30
- 239000000243 solution Substances 0.000 claims description 29
- 239000000853 adhesive Substances 0.000 claims description 23
- 230000001070 adhesive effect Effects 0.000 claims description 23
- 239000000080 wetting agent Substances 0.000 claims description 23
- 241000245665 Taraxacum Species 0.000 claims description 22
- 239000003795 chemical substances by application Substances 0.000 claims description 21
- 239000004088 foaming agent Substances 0.000 claims description 21
- 235000003599 food sweetener Nutrition 0.000 claims description 20
- 239000003765 sweetening agent Substances 0.000 claims description 20
- 238000000605 extraction Methods 0.000 claims description 19
- 239000006210 lotion Substances 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 17
- 239000008367 deionised water Substances 0.000 claims description 17
- 229910021641 deionized water Inorganic materials 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 11
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 10
- 235000019477 peppermint oil Nutrition 0.000 claims description 10
- 229940047522 long pepper extract Drugs 0.000 claims description 9
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- 229940067866 dandelion extract Drugs 0.000 claims description 8
- 235000020691 dandelion extract Nutrition 0.000 claims description 8
- 239000001845 taraxacum officinale leaf extract Substances 0.000 claims description 8
- 238000000227 grinding Methods 0.000 claims description 7
- 238000012859 sterile filling Methods 0.000 claims description 7
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical group OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 241000206575 Chondrus crispus Species 0.000 claims description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 229940081974 saccharin Drugs 0.000 claims description 5
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 5
- 235000019204 saccharin Nutrition 0.000 claims description 5
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 239000000419 plant extract Substances 0.000 claims description 4
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 3
- 229920002907 Guar gum Polymers 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
- 235000010417 guar gum Nutrition 0.000 claims description 3
- 229960002154 guar gum Drugs 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229940085605 saccharin sodium Drugs 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- 235000012907 honey Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 239000002324 mouth wash Substances 0.000 claims description 2
- 229940051866 mouthwash Drugs 0.000 claims description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 238000003809 water extraction Methods 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 229940040145 liniment Drugs 0.000 claims 1
- 239000000865 liniment Substances 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 8
- 210000000214 mouth Anatomy 0.000 abstract description 8
- 230000008961 swelling Effects 0.000 abstract description 5
- 230000002159 abnormal effect Effects 0.000 abstract description 4
- 208000020670 canker sore Diseases 0.000 abstract description 4
- 239000000796 flavoring agent Substances 0.000 abstract description 4
- 235000019634 flavors Nutrition 0.000 abstract description 4
- 201000001245 periodontitis Diseases 0.000 abstract description 4
- 208000004371 toothache Diseases 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 3
- 208000007565 gingivitis Diseases 0.000 abstract description 3
- 230000005180 public health Effects 0.000 abstract description 3
- 208000032843 Hemorrhage Diseases 0.000 abstract description 2
- 208000034158 bleeding Diseases 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 38
- 238000012360 testing method Methods 0.000 description 17
- 239000006071 cream Substances 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 5
- 229940105902 mint extract Drugs 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 206010006326 Breath odour Diseases 0.000 description 4
- 208000032139 Halitosis Diseases 0.000 description 4
- 241000194019 Streptococcus mutans Species 0.000 description 4
- -1 concentrated Substances 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 240000002853 Nelumbo nucifera Species 0.000 description 2
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 2
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
- 238000002242 deionisation method Methods 0.000 description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000001408 fungistatic effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- VXWYQEYFYNAZOD-UHFFFAOYSA-N 2-[3-[(4,4-difluoropiperidin-1-yl)methyl]-4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]pyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound FC1(F)CCN(CC2=NN(CC(=O)N3CCC4=C(C3)N=NN4)C=C2C2=CN=C(NC3CC4=C(C3)C=CC=C4)N=C2)CC1 VXWYQEYFYNAZOD-UHFFFAOYSA-N 0.000 description 1
- IKOKHHBZFDFMJW-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-(2-morpholin-4-ylethoxy)pyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)OCCN1CCOCC1 IKOKHHBZFDFMJW-UHFFFAOYSA-N 0.000 description 1
- LPZOCVVDSHQFST-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-ethylpyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)CC LPZOCVVDSHQFST-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000010266 Aggressive Periodontitis Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010018291 Gingival swelling Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- NEAPKZHDYMQZCB-UHFFFAOYSA-N N-[2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]ethyl]-2-oxo-3H-1,3-benzoxazole-6-carboxamide Chemical compound C1CN(CCN1CCNC(=O)C2=CC3=C(C=C2)NC(=O)O3)C4=CN=C(N=C4)NC5CC6=CC=CC=C6C5 NEAPKZHDYMQZCB-UHFFFAOYSA-N 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 229920002582 Polyethylene Glycol 600 Polymers 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 201000006727 periodontosis Diseases 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Birds (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of compound traditional Chinese medicine composite, said composition is prepared from by the raw material components of following parts by weight：0.8~6 part of the Bi roots of grass, 0.6~4.5 part of the root of large-flowered skullcap, 0.4~3 part of dandelion, 0.4~3 part of honeysuckle, 0.4~1.6 part of peppermint.The invention also discloses the herbal mixture toothpaste containing the compound traditional Chinese medicine composite.Herbal mixture toothpaste of the present invention can be clearing heat and detoxicating, antipyretic-antalgic, prevents bleeding gums；There is antibacterial, anti-inflammatory, effect of reducing internal heat again, gingivitis, periodontitis, bleeding gums, canker sore, swelling and aching of gum, toothache, permanent tooth shield gum can be effectively prevented and treated；Oral cavity can be cleaned well, be nursed simultaneously, being removed removing abnormal flavor in oral cavity, implication is kept pure and fresh；With obvious public health value and commercial value.
Description
Technical field
The present invention relates to technical field of toothpaste, it is related to a kind of compound traditional Chinese medicine composite, containing the compound traditional Chinese medicine composite
Toothpaste and preparation method thereof.
Background technology
On June 13rd, 2007, the Ministry of Public Health announce national third time oral health epidemiological survey result show,
China's mouth disease illness rate is up to more than 90%.The oral healthy condition of compatriots causes anxiety really, wherein, carious tooth and periodontosis into
For two most fearful big killers.And the pain that they bring allows patient suffering endlessly, serious shadow is generated to patients ' life quality
Ring.
Chinese herbal medicine possesses good treatment and approved with prophylactic effect by Chinese consumers in general, Chinese medicine tooth
Cream can prevent and treat oral disease also to be accepted with regard to natural.With carrying for expanding economy and quality of the life
Height, Chinese medicinal toothpaste more conforms to consumer and gets close to natural psychological needs.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of compound traditional Chinese medicine composite；Herbal mixture of the present invention
Toothpaste have obvious sterilizing oral, clean, go removing abnormal flavor in oral cavity, reduce internal heat, canker sore, swelling and aching of gum, toothache the effects such as.
To reach above-mentioned purpose, technical scheme is as follows：
A kind of compound traditional Chinese medicine composite, the compound traditional Chinese medicine composite is prepared from by the raw material components of following parts by weight：Bi
0.8~6 part of the roots of grass, 0.6~4.5 part of the root of large-flowered skullcap, 0.4~3 part of dandelion, 0.4~3 part of honeysuckle, 0.4~1.6 part of peppermint.
It is preferred that, described compound traditional Chinese medicine composite is prepared from by the raw material components of following parts by weight：1~5 part of the Bi roots of grass,
0.8~4 part of the root of large-flowered skullcap, 0.6~3 part of dandelion, 0.8~2 part of honeysuckle, 0.4~1.6 part of peppermint.
It is further preferred that described compound traditional Chinese medicine composite is prepared from by the raw material components of following parts by weight：The Bi roots of grass 1
~4.5 parts, 1~3 part of the root of large-flowered skullcap, 0.8~2 part of dandelion, 1~2 part of honeysuckle, 0.4~1.5 part of peppermint.
Compound traditional Chinese medicine composite of the present invention prepare with sterilizing oral, clean, go removing abnormal flavor in oral cavity, reduce internal heat,
Application in the toothpaste or mouthwash of the effects such as canker sore, swelling and aching of gum, toothache.
A kind of toothpaste containing compound traditional Chinese medicine composite of the present invention, lotion of toothpaste by following parts by weight raw material group
Divide and be made：0.8~6 part of the Bi roots of grass, 0.6~4.5 part of the root of large-flowered skullcap, 0.4~3 part of dandelion, 0.4~3 part of honeysuckle, peppermint 0.4~1.6
Part, 10~25 parts of rubbing agent, 10~50 parts of wetting agent, 0.4~2 part of adhesive, 1~2 part of foaming agent, sweetener 0.05~0.4
Part, 0.5~1.3 part of aromatic, 18~60 parts of deionized water.The summation of above-mentioned raw materials component is 100 parts by weight.
It is preferred that, described lotion of toothpaste is made up of the raw material components of following parts by weight：1~5 part of the Bi roots of grass, the root of large-flowered skullcap 0.8~4
Part, 0.6~3 part of dandelion, 0.8~2 part of honeysuckle, 0.4~1.6 part of peppermint, 10~25 parts of rubbing agent, wetting agent 10~50
Part, 0.4~1.8 part of adhesive, 1.2~2 parts of foaming agent, 0.05~0.4 part of sweetener, 0.5~1.3 part of aromatic, deionization
18~60 parts of water.
It is further preferred that described lotion of toothpaste is made up of the raw material components of following parts by weight：1~4.5 part of the Bi roots of grass, Huang
1~3 part of a kind of reed mentioned in ancient books, 0.8~2 part of dandelion, 1~2 part of honeysuckle, 0.4~1.5 part of peppermint, 15~22 parts of rubbing agent, wetting agent 20~
50 parts, 1~1.8 part of adhesive, 1.2~1.6 parts of foaming agent, 0.05~0.2 part of sweetener, 0.5~1 part of aromatic, deionization
18~58 parts of water.
Described rubbing agent is one or more in calcium carbonate, calcium monohydrogen phosphate, silica.
Described wetting agent is the one or more in sorbierite, glycerine, propane diols, polyethylene glycol.Low molecule amount it is poly-
Ethylene glycol can be used in toothpaste, and such as molecular weight is used primarily in the toothpaste without carboxymethyl cellulose less than PEG-400, PEG-
600 are used in the toothpaste containing carboxymethyl cellulose.
Described mixture is one kind in sodium carboxymethylcellulose, xanthans, hydroxyethyl cellulose, guar gum, carragheen
Or it is several.
Described foaming agent is lauryl sodium sulfate.
Described sweetener is one or more in saccharin sodium sucrose, saccharin, honey element, xylitol.
Described aromatic is peppermint oil.
A kind of herbal mixture toothpaste of the present invention is extracted by Chinese medicinal material, concentrated, and extract is made, then by Chinese medicine
Extract is mixed with rubbing agent, wetting agent, adhesive, foaming agent, sweetener, aromatic and deionized water, by high-speed stirred
Lotion of toothpaste is obtained, then herbal mixture lotion of toothpaste sterile filling is entered in flexible pipe to seal, herbal mixture toothpaste finished product is obtained.
The preparation method of herbal mixture toothpaste of the present invention, comprises the following steps：
(1), prepared plant extracts：
By the removal of impurities of Bi roots of grass medicinal materials, crushing, alcohol extracting, it is condensed into medicinal extract；By the removal of impurities of dandelion medicinal material, alcohol extracting, it is condensed into medicinal extract；
Respectively by the root of large-flowered skullcap, honeysuckle, the removal of impurities of peppermint medicinal material, water extraction, be condensed into medicinal extract；
(2), by long pepper extract made from step (1), Baical Skullcap root P.E, dandelion extract, Honegsukle flower P.E, thin
Lotus extract and rubbing agent, wetting agent, adhesive, foaming agent, sweetener, deionized water mixing, send into vacuum Manufacturing medicine extract machine, stirring
Uniformly, vacuum outgas；Aromatic grinding is added, mixes, obtains herbal mixture lotion of toothpaste；Herbal mixture lotion of toothpaste is sterile to be filled
It is fitted into flexible pipe and seals, obtains herbal mixture toothpaste finished product.
It is preferred that, the preparation method of described herbal mixture toothpaste comprises the following steps：
(1), prepared plant extracts：
Take Bi roots of grass medicinal materials, remove impurity, crushed 40 mesh sieves, 2~3 times are extracted with 60%~90% alcohol reflux, every time 1
~2 hours, it was 1: 5~1: 15 that solvent measures (the ratio between volume mass for solvent and medicinal material, unit is L/kg) again, merges and extracts
Liquid, is concentrated under reduced pressure, and obtains the medicinal extract of relative density 1.0~1.2, as long pepper extract；
Take radix scutellariae medicinal materials, remove impurity, with water refluxing extraction 2~3 times, 1~2 hour every time, solvent was measured as 1: 5~1 again:
15, merge extract solution, be concentrated under reduced pressure, obtain the medicinal extract of relative density 1.0~1.2, as Baical Skullcap root P.E；
Dandelion medicinal material is taken, impurity is removed, is extracted 2~3 times with 60%~90% alcohol reflux, it is 1~3 hour every time, molten
Matchmaker is measured as 1: 5~1: 20 again, merges extract solution, is concentrated under reduced pressure, and obtains the medicinal extract of relative density 1.0~1.2, and as dandelion is extracted
Thing；
Extracting honeysuckle medicinal material, removes impurity, with water refluxing extraction 2~3 times, 1~2 hour every time, and solvent measures as 1: 5 again~
1: 20, merge extract solution, be concentrated under reduced pressure, obtain the medicinal extract of relative density 1.0~1.2, as Honegsukle flower P.E；
Peppermint medicinal material is taken to remove after impurity, with water refluxing extraction 2~3 times, 1~3 hour every time, solvent was measured as 1: 5~1 again
: 20, merge extract solution, be concentrated under reduced pressure, obtain the medicinal extract of relative density 1.0~1.2, as mint extract；
(2), by long pepper extract made from step (1), Baical Skullcap root P.E, dandelion extract, Honegsukle flower P.E, thin
Lotus extract, wetting agent and sweetener are put into deionized water, stir to whole dissolvings, then with rubbing agent, adhesive, foaming agent
Mixing, sends into vacuum Manufacturing medicine extract machine, stirs, vacuum outgas；Aromatic grinding is added, mixes, obtains herbal mixture toothpaste cream
Body；Herbal mixture lotion of toothpaste sterile filling, which enters in flexible pipe, to be sealed, and obtains herbal mixture toothpaste finished product.
Beneficial effects of the present invention：
Herbal mixture toothpaste of the present invention adds 5 kinds of Chinese medical extracts and is used as natural medicinal plants on the basis of ordinary toothpaste
The raw material of active component, wherein monarch drug in a prescription root of large-flowered skullcap bitter cold, You Shanqing let out middle dampness-heat in upper jiao and lung-fire；Dandelion, the medicine phases of honeysuckle two
Must be to use, two medicine phases are closed, and the heat of the clear part of the body cavity above the diaphragm housing the heart and lungs of principal drug assistance again can relieving heat toxin；The Bi roots of grass is pungent, heat, has both been apt to warming spleen and stomach for dispelling cold, broken stagnant gas, has opened
Pent-up, and the superficial heat of the part of the body cavity above the diaphragm housing the heart and lungs can be dissipated；Peppermint is pungent, cool, light clear floating, both head clearing, and priming is up.This herbal mixture toothpaste
Based on traditional Chinese medical theory, compatibility application is carried out, is had compared with the ointment using single Chinese medical extract as active ingredient significant
Effect, can be clearing heat and detoxicating, antipyretic-antalgic, prevents bleeding gums；There is antibacterial, anti-inflammatory, effect of reducing internal heat again, tooth can be effectively prevented and treated
Oulitis, periodontitis, bleeding gums, canker sore, swelling and aching of gum, toothache, permanent tooth shield gum；Oral cavity can be carried out well simultaneously clear
Clean, nursing, removes removing abnormal flavor in oral cavity, implication is kept pure and fresh；With obvious public health value and commercial value.
Embodiment
Technical scheme is described further below by embodiment.
Embodiment 1
A kind of herbal mixture toothpaste, is made up of the raw material components of following parts by weight：1.2 parts of the Bi roots of grass, 1 part of the root of large-flowered skullcap, dandelion
0.8 part, 1 part of honeysuckle, 0.5 part of peppermint, 15 parts of calcium carbonate (rubbing agent), 20 parts of sorbierite (wetting agent), carboxymethyl cellulose
1 part of sodium (adhesive), 0.2 part of guar gum (adhesive), 1.2 parts of lauryl sodium sulfate (foaming agent), saccharin sodium (sweetener)
0.08 part, 0.8 part of peppermint oil, 57.22 parts of deionized water.The herbal mixture toothpaste is made by following preparation method, and step is as follows：
(1) Bi roots of grass medicinal materials, are taken, impurity is removed, crushed 40 mesh sieves, are extracted 2 times with 60% alcohol reflux, 1.5 is small every time
When, solvent is measured as 1: 8 again, and 2 gained extract solutions are merged, is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.0；
Take radix scutellariae medicinal materials, remove impurity, with water refluxing extraction 2 times, 1.5 hours every time, solvent was measured as 1: 10 again, by 2 times
Gained extract solution merges, and is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.0；
Take dandelion medicinal material, remove impurity, 2 times are extracted with 75% alcohol reflux, 2 hours every time, solvent was measured as 1: 20 again,
2 gained extract solutions are merged, is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.15；
Extracting honeysuckle medicinal material, removes impurity, with water refluxing extraction 2 times, 1.5 hours every time, and solvent is measured as 1: 20 again, by 2
Secondary gained extract solution merges, and is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.1；
Take peppermint medicinal material, remove impurity, with water refluxing extraction 2 times, 2 hours every time, solvent was measured as 1: 8 again, by 2 gained
Extract solution merges, and is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.15；
(2), by long pepper extract, Baical Skullcap root P.E, dandelion extract, Honegsukle flower P.E, mint extract, wetting
Agent and sweetener are put into deionized water stirring to dissolving, then mixs with rubbing agent, adhesive, foaming agent and send into vacuum cream
Machine, stirs 25~40min, vacuum outgas；Add peppermint oil grinding to mix for 5~15 minutes, obtain herbal mixture lotion of toothpaste, it is sterile
It is filled into flexible pipe and seals, just obtains herbal mixture toothpaste finished product.
Embodiment 2
A kind of herbal mixture toothpaste, is made up of the raw material components of following parts by weight：2 parts of the Bi roots of grass, 1.5 parts of the root of large-flowered skullcap, dandelion
1.8 parts, 1.3 parts of honeysuckle, 1.1 parts of peppermint, 18 parts of calcium monohydrogen phosphate (rubbing agent), 50 parts of sorbierite (wetting agent), carboxymethyl it is fine
Plain 1.2 parts of the sodium (adhesive) of dimension, 0.5 part of carragheen (adhesive), 1.6 parts of lauryl sodium sulfate (foaming agent), saccharin (sweet taste
Agent) 0.1 part, 0.7 part of peppermint oil (aromatic), 20.3 parts of deionized water.The herbal mixture toothpaste is made by following preparation method,
Step is as follows：
(1) Bi roots of grass medicinal materials, are taken, impurity is removed, crushed 40 mesh sieves, are extracted 2 times with 70% alcohol reflux, 1.5 is small every time
When, solvent is measured as 1: 10 again, and 2 gained extract solutions are merged, is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.2；
Take radix scutellariae medicinal materials, remove impurity, with water refluxing extraction 2 times, 1.5 hours every time, solvent was measured as 1: 15 again, by 2 times
Gained extract solution merges, and is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.1；
Dandelion medicinal material is taken, impurity is removed, is extracted with 60% ethanol, refluxing extraction 2 times, 2 hours every time, solvent is measured again was
1: 15,2 gained extract solutions are merged, is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.2；
Extracting honeysuckle medicinal material, removes impurity, with water refluxing extraction 2 times, 1.5 hours every time, and solvent is measured as 1: 10 again, by 2
Secondary gained extract solution merges, and is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.15；
Take peppermint medicinal material, remove impurity, with water refluxing extraction 2 times, 2 hours every time, solvent was measured as 1: 10 again, by 2 institutes
Obtain extract solution to merge, be concentrated under reduced pressure, obtain the medicinal extract of relative density 1.2；
(2), by long pepper extract, Baical Skullcap root P.E, dandelion extract, Honegsukle flower P.E, mint extract, wetting
Agent and sweetener are put into deionized water stirring to dissolving, then mixs with rubbing agent, adhesive, foaming agent and send into vacuum cream
Machine, 25~40min of high-speed stirred, vacuum outgas；Add peppermint oil grinding to mix for 5~15 minutes, obtain herbal mixture lotion of toothpaste,
Sterile filling, which enters in flexible pipe, to be sealed, and just obtains herbal mixture toothpaste finished product.
Embodiment 3
A kind of herbal mixture toothpaste, is made up of the raw material components of following parts by weight：1.5 parts of the Bi roots of grass, 2 parts of the root of large-flowered skullcap, dandelion
1.6 parts, 1.8 parts of honeysuckle, 1.5 parts of peppermint, 17 parts of silica (rubbing agent), 20 parts of sorbierite (wetting agent), polyethylene glycol
400 25 parts of (wetting agent), 1.1 parts of hydroxyethyl cellulose (adhesive), 0.2 part of carragheen (adhesive), lauryl sodium sulfate
1.5 parts of (foaming agent), 0.2 part of saccharin (sweetener), 0.5 part of peppermint oil (aromatic), 26.1 parts of deionized water.The herbal mixture
Toothpaste is made by following preparation method, and step is as follows：
(1), take Bi roots of grass medicinal material to remove after impurity, crush, extracted 2 times with 80% alcohol reflux, 1.5 hours, solvent every time
Amount is 1: 15 again, and 2 gained extract solutions are merged, is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.15.
Take radix scutellariae medicinal materials, remove impurity, with water refluxing extraction 2 times, 1.5 hours every time, solvent was measured as 1: 8 again, by 2 institutes
Obtain extract solution to merge, be concentrated under reduced pressure, obtain the medicinal extract of relative density 1.2.
Take dandelion medicinal material, remove impurity, 2 times are extracted with 70% alcohol reflux, 2 hours every time, solvent was measured as 1: 10 again,
2 gained extract solutions are merged, is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.1.
Extracting honeysuckle medicinal material, removes impurity, with water refluxing extraction 2 times, 1.5 hours every time, and solvent is measured as 1: 15 again, by 2
Secondary gained extract solution merges, and is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.15.
Take peppermint medicinal material, remove impurity, with water refluxing extraction 2 times, 2 hours every time, solvent was measured as 1: 10 again, by 2 institutes
Obtain extract solution to merge, be concentrated under reduced pressure, obtain the medicinal extract of relative density 1.2.
(2), by long pepper extract, Baical Skullcap root P.E, dandelion extract, Honegsukle flower P.E, mint extract, wetting
Agent and sweetener are put into deionized water stirring to dissolving, then mixs with rubbing agent, adhesive, foaming agent and send into vacuum cream
Machine, 25~40min of high-speed stirred, vacuum outgas；Add peppermint oil grinding to be stirred for mixing for 5~15 minutes, obtain herbal mixture tooth
Cream lotion, sterile filling, which enters in flexible pipe, to be sealed, and just obtains herbal mixture toothpaste finished product.
Embodiment 4
A kind of herbal mixture toothpaste, is made up of the raw material components of following parts by weight：4 parts of the Bi roots of grass, 3 parts of the root of large-flowered skullcap, dandelion 2
Part, 2 parts of honeysuckle, 1 part of peppermint, 20 parts of calcium carbonate (rubbing agent), 25 parts of sorbierite (wetting agent), polyethylene glycol 400 (wetting
Agent) 20 parts, 1.3 parts of sodium carboxymethylcellulose (adhesive), 0.4 part of carragheen (adhesive), lauryl sodium sulfate (foaming
Agent) 1.6 parts, 0.1 part of saccharin (sweetener), 0.8 part of peppermint oil (aromatic), 18.8 parts of deionized water.The herbal mixture toothpaste
It is made by following preparation method, step is as follows：
(1) Bi roots of grass medicinal materials, are taken, impurity is removed, crushed, are extracted 2 times with 75% alcohol reflux, 1.5 hours every time, solvent times
Measure as 1: 10,2 gained extract solutions are merged, is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.15；
Take radix scutellariae medicinal materials, remove impurity, with water refluxing extraction 2 times, 1.5 hours every time, solvent was measured as 1: 10 again, by 2 times
Gained extract solution merges, and is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.10；
Take dandelion medicinal material, remove impurity, 2 times are extracted with 75% alcohol reflux, 2 hours every time, solvent was measured as 1: 20 again,
2 gained extract solutions are merged, is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.15；
Extracting honeysuckle medicinal material, removes impurity, with water refluxing extraction 2 times, 1.5 hours every time, and solvent is measured as 1: 10 again, by 2
Secondary gained extract solution merges, and is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.10；
Take peppermint medicinal material, remove impurity, with water refluxing extraction 2 times, 2 hours every time, solvent was measured as 1: 20 again, by 2 institutes
Obtain extract solution to merge, be concentrated under reduced pressure, obtain the medicinal extract of relative density 1.15；
(2), by long pepper extract, Baical Skullcap root P.E, dandelion extract, Honegsukle flower P.E, mint extract, wetting
Agent and sweetener are put into deionized water stirring to dissolving, then mixs with rubbing agent, adhesive, foaming agent and send into vacuum cream
Machine, 25~40min of high-speed stirred, vacuum outgas；Add peppermint oil to be stirred for mixing for 5~15 minutes, obtain herbal mixture toothpaste cream
Body, sterile filling, which enters in flexible pipe, to be sealed, and just obtains herbal mixture toothpaste finished product.
Effect test
Experiment one：Fungistatic effect is determined
1st, test method：Herbal mixture toothpaste is subjected to bacteriostatic test to streptococcus mutans, herbal mixture toothpaste pair is observed
The direct bacteriostasis of streptococcus mutans.The gained toothpaste of embodiment 1,2,3,4 is made into 20% aqueous solution, takes its leachate conduct
Tested sample liquid, carries out bacteriostatic test, detects its bacteriostasis rate, and bacteriostasis rate is calculated by formula (A1)：
X=(A-B)/A × 100% ... (A1)
In formula：X-bacteriostasis rate, %；
A-negative control group average colony number；
B-subject sample average clump count.
2nd, test procedure：
(1), the preparation of slant medium：Claim peptone 5g, beef extract 3g, agar 15g, heating for dissolving is distilled in 1000mL
In water, test tube is dispensed, 121 DEG C of autoclavings 15 minutes are standby, are put into inclined-plane.
(2), the preparation of bacteria suspension：Take streptococcus mutans to be inoculated on the slant medium of step (1), cultivate 24h.Use PBS
Lower lawn is washed, regulation bacterial concentration is 4 × 104cfu/mL。
(3), the sample group of toothpaste test containing herbal mixture：Example 1,2,3,4 prepares the tested sample liquid of toothpaste containing herbal mixture
(5mL is each) 3 is managed, and takes above-mentioned bacteria suspension, 100 μ L bacteria suspensions are added dropwise in each tested sample liquid respectively, uniform mixing, starts meter
When, 10min is acted on, the sample liquid (0.5mL) that above-mentioned drop has bacteria suspension is put into the test tube containing 5mLPBS respectively with sterile tweezer, filled
Divide and mix, draw 0.5mL, be respectively placed in three plates, poured into MS culture mediums 15mL, rotate plate, make its full and uniform,
Flat board, 37 DEG C of Anaerobic culturels, condition of culture are overturn after agar solidification：80%N2, 10%CO2, 10%H2, cultivate 48h and make viable bacteria bacterium
Fall to count, average.
(4), without herbal mixture toothpaste test sample group：Toothpaste is prepared (but without compound with the matrix in embodiment 1
Chinese medicine composition), take its 20% aqueous solution to leach thing liquid, other operations are with the sample group of toothpaste test containing compound traditional Chinese medicine composite.
(5), negative control group：Take 0.5mL bacteria suspensions to put into the test tube containing 5mLPBS respectively, fully mix, draw
0.5mL, is respectively placed in three plates, is poured into MS culture mediums 15mL, rotates plate, makes its full and uniform, after agar solidification
Overturn flat board, 37 DEG C of Anaerobic culturels, condition of culture：80%N2, 10%CO2, 10%H2, cultivate 48h and make viable bacteria colony counting, take
Average value.
(6), comparative example sample group：Toothpaste is prepared with reference to the preparation method of embodiment 4, the concrete component proportioning of use is seen below
Table 1；The comparative example 1-17 toothpaste prepared is made into 20% aqueous solution, takes it to leach thing liquid, other operations are with group containing herbal mixture
Compound toothpaste test sample group.
The component allocation table of the comparative example of table 1
3rd, interpretation of result
According to《Disinfection technology standard》Bacteriostasis rate evaluation criterion：Bacteriostasis rate 50-90%, product has bacteriostasis, bacteriostasis rate
>=90%, product has stronger bacteriostasis.Reflect from the analysis result of table 2：Contain compound according to prepared by embodiment 1,2,3,4
Chinese medicinal toothpaste has stronger fungistatic effect to streptococcus mutans；The present invention is effective by the way that 5 kinds of Chinese medicine composition combinations are carried out
Proportioning, is compared with using a kind in 5 kinds of Chinese medical extracts, 2 kinds, 3 kinds, 4 kinds of any combination, serves significantly synergy work
With.
The bacteriostasis rate analysis of experiments result of table 2
| Toothpaste sample | Bacteriostasis rate (%) | Toothpaste sample | Bacteriostasis rate (%) |
| Embodiment 1 | 99.93 | Comparative example 8 | 65.42 |
| Embodiment 2 | 99.95 | Comparative example 9 | 60.21 |
| Embodiment 3 | 99.94 | Comparative example 10 | 70.41 |
| Embodiment 4 | 99.97 | Comparative example 11 | 67.88 |
| Comparative example 1 | 55.53 | Comparative example 12 | 68.23 |
| Comparative example 2 | 54.45 | Comparative example 13 | 85.62 |
| Comparative example 3 | 53.22 | Comparative example 14 | 81.53 |
| Comparative example 4 | 54.66 | Comparative example 15 | 80.96 |
| Comparative example 5 | 52.28 | Comparative example 16 | 79.25 |
| Comparative example 6 | 65.93 | Comparative example 17 | 72.43 |
| Comparative example 7 | 65.22 | Without herbal mixture toothpaste | 22.33 |
Experiment two：Clinical efficacy
1st, the principle of experimental design：
1.1 subjects provide embodiment 1-4, comparative example 1-17 and without herbal mixture preparation at random according to screening order
Toothpaste sample, every kind of toothpaste subject is 40.
1.2 personnel for being responsible for test index inspection should not know about subject and be grouped situation at random.And there is full-time staff to carry out
The work such as test specimen granting registration.In the case of conditional, it is that subject must not be also understood used by it for which kind of sample.
2nd, subject selects：
2.1 inclusive criterias
A) whole body health in order, without important whole body system disease, have more than 20 detectable teeth.
B) age is in one full year of life 18 one full year of life -70.
C), must not be within the gestational period and nursing period if women.
D) subject should have suitable degree of gingivitis.
E) other similar experimental studies are not participated in simultaneously.
F) informed consent form is signed, clinical test can be completed on request.
2.2 exclusion standards
A) there are allergies to experiment toothpaste component.
B) medicine influential on result of the test is taken now.
C) antibiotic is used by the previous moon in participation research.
D) there are open carious tooth or mucosa infection in oral cavity.
E) serious periodontitis is suffered from.
3rd, process of the test
Using the toothpaste of this experiment, everyone brushes teeth sooner or later, every time 1~2g, brushes teeth every time 3~5 minutes.
4th, duration of trial
Test period is 3 months, to strengthen the compliance of subject, takes monthly hair primary production and toothbrush etc., plays
Supervise and understand in time the effect of adverse reaction etc..
5th, observational technique and index
Before using toothpaste and using 10 days after toothpaste, do within 20 days clinical examination record, including：Record patient main suit
Symptom, such as bleeding gums, redness, halitosis, front and rear change is used in toothpaste.
6th, efficacy evaluation
It is effective：In 10 days during first visit, pain disappears, and gum disappears without swelling, bleeding, halitosis.
Take a turn for the better：Pain relief after 10 days, gum swelling bleeding, halitosis mitigate.
It is invalid：Symptom is without improvement after 10 days.
Efficient=(effective number+improvement number)/total case load × 100%
Result of the test is as shown in table 3：
The each group clinical efficacy situation of table 3
| Group | It is effective | Take a turn for the better | It is invalid | Efficient (%) |
| Embodiment 1 | 25 | 12 | 3 | 92.5 |
| Embodiment 2 | 20 | 12 | 8 | 91.3 |
| Embodiment 3 | 27 | 10 | 3 | 92.5 |
| Embodiment 4 | 30 | 8 | 2 | 95.0 |
| Comparative example 1 | 5 | 15 | 20 | 50.0 |
| Comparative example 2 | 1 | 8 | 31 | 22.5 |
| Comparative example 3 | 3 | 13 | 24 | 40.0 |
| Comparative example 4 | 5 | 16 | 19 | 52.5 |
| Comparative example 5 | 7 | 6 | 27 | 32.5 |
| Comparative example 6 | 3 | 19 | 18 | 55.0 |
| Comparative example 7 | 11 | 8 | 21 | 47.5 |
| Comparative example 8 | 3 | 18 | 19 | 52.5 |
| Comparative example 9 | 10 | 14 | 16 | 60.0 |
| Comparative example 10 | 6 | 20 | 14 | 65.0 |
| Comparative example 11 | 2 | 16 | 22 | 45.0 |
| Comparative example 12 | 6 | 17 | 17 | 57.5 |
| Comparative example 13 | 1 | 17 | 22 | 45.0 |
| Comparative example 14 | 5 | 16 | 19 | 52.5 |
| Comparative example 15 | 8 | 10 | 22 | 45.0 |
| Comparative example 16 | 4 | 18 | 18 | 55.0 |
| Comparative example 17 | 1 | 19 | 20 | 50.0 |
| Without herbal mixture | 0 | 5 | 35 | 12.5 |
As a result show, herbal mixture toothpaste is made by the way that 5 kinds of Chinese medicine composition combinations are carried out into effectively proportioning in the present invention, and
The toothpaste being made using a kind in 5 kinds of Chinese medical extracts, 2 kinds, 3 kinds, 4 kinds of any combination as active ingredient is compared, and is had
Significantly effect, can not only be clearing heat and detoxicating, antipyretic-antalgic, prevents bleeding gums, at the same can also effectively antibacterial, anti-inflammatory, to prevent and treat
Gingivitis, periodontitis, bleeding gums, permanent tooth shield gum, oral cavity is nursed, it is pre- it is anti-halitosis make implication holding it is pure and fresh.
Claims (10)
1. a kind of compound traditional Chinese medicine composite, it is characterised in that the compound traditional Chinese medicine composite is prepared by the raw material components of following parts by weight
Form：0.8~6 part of the Bi roots of grass, 0.6~4.5 part of the root of large-flowered skullcap, 0.4~3 part of dandelion, 0.4~3 part of honeysuckle, peppermint 0.4~1.6
Part.
2. compound traditional Chinese medicine composite according to claim 1, it is characterised in that described compound traditional Chinese medicine composite is by following
The raw material components of parts by weight are prepared from：1~5 part of the Bi roots of grass, 0.8~4 part of the root of large-flowered skullcap, 0.6~3 part of dandelion, honeysuckle 0.8~2
Part, 0.4~1.6 part of peppermint.
3. compound traditional Chinese medicine composite according to claim 2, it is characterised in that described compound traditional Chinese medicine composite is by following
The raw material components of parts by weight are prepared from：1~4.5 part of the Bi roots of grass, 1~3 part of the root of large-flowered skullcap, 0.8~2 part of dandelion, 1~2 part of honeysuckle,
0.4~1.5 part of peppermint.
4. application of the compound traditional Chinese medicine composite described in claim 1,2 or 3 in toothpaste or mouthwash is prepared.
5. a kind of herbal mixture toothpaste of the compound traditional Chinese medicine composite containing described in claim 1, it is characterised in that lotion of toothpaste
It is made up of the raw material components of following parts by weight：0.8~6 part of the Bi roots of grass, 0.6~4.5 part of the root of large-flowered skullcap, 0.4~3 part of dandelion, honeysuckle
0.4~3 part, 0.4~1.6 part of peppermint, 10~25 parts of rubbing agent, 10~50 parts of wetting agent, 0.4~2 part of adhesive, foaming agent 1
~2 parts, 0.05~0.4 part of sweetener, 0.5~1.3 part of aromatic, 18~60 parts of deionized water.
6. herbal mixture toothpaste according to claim 5, it is characterised in that lotion of toothpaste by following parts by weight raw material group
Divide and be made：1~5 part of the Bi roots of grass, 0.8~4 part of the root of large-flowered skullcap, 0.6~3 part of dandelion, 0.8~2 part of honeysuckle, 0.4~1.6 part of peppermint,
10~25 parts of rubbing agent, 10~50 parts of wetting agent, 0.4~1.8 part of adhesive, 1.2~2 parts of foaming agent, sweetener 0.05~0.4
Part, 0.5~1.3 part of aromatic, 18~60 parts of deionized water.
7. herbal mixture toothpaste according to claim 6, it is characterised in that lotion of toothpaste by following parts by weight raw material group
Divide and be made：1~4.5 part of the Bi roots of grass, 1~3 part of the root of large-flowered skullcap, 0.8~2 part of dandelion, 1~2 part of honeysuckle, 0.4~1.5 part of peppermint, rub
15~22 parts of liniment, 20~50 parts of wetting agent, 1~1.8 part of adhesive, 1.2~1.6 parts of foaming agent, sweetener 0.05~0.2
Part, 0.5~1 part of aromatic, 18~58 parts of deionized water.
8. the herbal mixture toothpaste according to claim 5,6 or 7, it is characterised in that described rubbing agent is calcium carbonate, phosphorus
It is one or more of in sour hydrogen calcium, silica；
Described wetting agent is the one or more in sorbierite, glycerine, propane diols, polyethylene glycol；
Described mixture is one kind or several in sodium carboxymethylcellulose, xanthans, hydroxyethyl cellulose, guar gum, carragheen
Kind；
Described foaming agent is lauryl sodium sulfate；
Described sweetener is one or more in saccharin sodium sucrose, saccharin, honey element, xylitol；
Described aromatic is peppermint oil.
9. the preparation method of the herbal mixture toothpaste described in any one of claim 5-8, it is characterised in that comprise the following steps：
(1), prepared plant extracts：By the removal of impurities of Bi roots of grass medicinal materials, crushing, alcohol extracting, it is condensed into medicinal extract；By the removal of impurities of dandelion medicinal material,
Alcohol extracting, it is condensed into medicinal extract；Respectively by the root of large-flowered skullcap, honeysuckle, the removal of impurities of peppermint medicinal material, water extraction, be condensed into medicinal extract；
(2), long pepper extract, Baical Skullcap root P.E, dandelion extract, Honegsukle flower P.E, peppermint made from step (1) are carried
Thing and rubbing agent, wetting agent, adhesive, foaming agent, sweetener, deionized water mixing are taken, vacuum Manufacturing medicine extract machine is sent into, stirring is equal
It is even, vacuum outgas；Aromatic grinding is added, mixes, obtains herbal mixture lotion of toothpaste；Herbal mixture lotion of toothpaste sterile filling
Enter in flexible pipe and seal, obtain herbal mixture toothpaste finished product.
10. the preparation method of herbal mixture toothpaste according to claim 9, it is characterised in that comprise the following steps：
(1), prepared plant extracts：
Take Bi roots of grass medicinal materials, remove impurity, crushed 40 mesh sieves, 2~3 times are extracted with 60%~90% alcohol reflux, every time 1~2
Hour, solvent is measured as 1: 5~1: 15 again, merges extract solution, is concentrated under reduced pressure, obtains the medicinal extract of relative density 1.0~1.2；
Take radix scutellariae medicinal materials, remove impurity, with water refluxing extraction 2~3 times, 1~2 hour every time, solvent was measured as 1: 5~1: 15 again,
Merge extract solution, be concentrated under reduced pressure, obtain the medicinal extract of relative density 1.0~1.2；
Dandelion medicinal material is taken, impurity is removed, is extracted 2~3 times with 60%~90% alcohol reflux, 1~3 hour every time, solvent times
Measure as 1: 5~1: 20, merge extract solution, be concentrated under reduced pressure, obtain the medicinal extract of relative density 1.0~1.2；
Extracting honeysuckle medicinal material, removes impurity, and with water refluxing extraction 2~3 times, 1~2 hour every time, solvent was measured as 1: 5~1 again:
20, merge extract solution, be concentrated under reduced pressure, obtain the medicinal extract of relative density 1.0~1.2；
Peppermint medicinal material is taken to remove after impurity, with water refluxing extraction 2~3 times, 1~3 hour every time, solvent was measured as 1: 5~1: 20 again,
Merge extract solution, be concentrated under reduced pressure, obtain the medicinal extract of relative density 1.0~1.2；
(2), long pepper extract, Baical Skullcap root P.E, dandelion extract, Honegsukle flower P.E, peppermint made from step (1) are carried
Take thing, wetting agent and sweetener to be put into deionized water, stir to whole dissolvings, then mixed with rubbing agent, adhesive, foaming agent
Close, send into vacuum Manufacturing medicine extract machine, stir, vacuum outgas；Aromatic grinding is added, mixes, obtains herbal mixture lotion of toothpaste；
Herbal mixture lotion of toothpaste sterile filling, which enters in flexible pipe, to be sealed, and obtains herbal mixture toothpaste finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710123121.9A CN106937925A (en) | 2017-03-03 | 2017-03-03 | A kind of compound traditional Chinese medicine composite and toothpaste containing the compound traditional Chinese medicine composite and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710123121.9A CN106937925A (en) | 2017-03-03 | 2017-03-03 | A kind of compound traditional Chinese medicine composite and toothpaste containing the compound traditional Chinese medicine composite and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106937925A true CN106937925A (en) | 2017-07-11 |
Family
ID=59469521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710123121.9A Pending CN106937925A (en) | 2017-03-03 | 2017-03-03 | A kind of compound traditional Chinese medicine composite and toothpaste containing the compound traditional Chinese medicine composite and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106937925A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042384A (en) * | 2018-01-08 | 2018-05-18 | 弘美制药（中国）有限公司 | A kind of composition with oral cleaning and therapeutic efficiency |
| CN108685989A (en) * | 2018-07-18 | 2018-10-23 | 黑龙江福和制药集团股份有限公司 | A kind of dandelion essence cream and its preparation method |
| CN109498524A (en) * | 2018-12-30 | 2019-03-22 | 广东新南方青蒿日化有限公司 | A kind of Chinese medicine compound prescription sweet wormwood toothpaste and preparation method thereof |
| CN109620774A (en) * | 2019-01-28 | 2019-04-16 | 荆楚理工学院 | A kind of herbal mixture care toothpaste and preparation method thereof |
| CN111388560A (en) * | 2020-04-16 | 2020-07-10 | 广东君道营养科技有限公司 | Traditional Chinese medicine composition for inhibiting formation of dental plaque, preparation method and application thereof |
| CN111956549A (en) * | 2020-08-27 | 2020-11-20 | 上海蔚艺生物科技有限公司 | Toothpaste with compatibility of plant essences and application of toothpaste |
| CN112716854A (en) * | 2021-01-27 | 2021-04-30 | 新乡博凯生物技术有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN114832036A (en) * | 2022-05-13 | 2022-08-02 | 漳州无极药业有限公司 | Medicinal composition for treating gingivitis and preparation method thereof |
| CN114983898A (en) * | 2022-07-05 | 2022-09-02 | 贵州苗老藤化妆品生产制造有限公司 | Chinese herbal medicine toothpaste and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269195A (en) * | 2008-05-14 | 2008-09-24 | 徐泽林 | Proprietary Chinese medicine for treating toothache |
| CN102389388A (en) * | 2011-11-28 | 2012-03-28 | 江西诚志日化有限公司 | Piper longum toothpaste and preparation method thereof |
| CN103356443A (en) * | 2013-08-06 | 2013-10-23 | 谢安军 | Toothpaste |
| CN104887555A (en) * | 2015-05-06 | 2015-09-09 | 绥阳县吉帮金银花科技发展有限公司 | Honeysuckle flower toothpaste and preparation method thereof |
-
2017
- 2017-03-03 CN CN201710123121.9A patent/CN106937925A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269195A (en) * | 2008-05-14 | 2008-09-24 | 徐泽林 | Proprietary Chinese medicine for treating toothache |
| CN102389388A (en) * | 2011-11-28 | 2012-03-28 | 江西诚志日化有限公司 | Piper longum toothpaste and preparation method thereof |
| CN103356443A (en) * | 2013-08-06 | 2013-10-23 | 谢安军 | Toothpaste |
| CN104887555A (en) * | 2015-05-06 | 2015-09-09 | 绥阳县吉帮金银花科技发展有限公司 | Honeysuckle flower toothpaste and preparation method thereof |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042384A (en) * | 2018-01-08 | 2018-05-18 | 弘美制药（中国）有限公司 | A kind of composition with oral cleaning and therapeutic efficiency |
| CN108042384B (en) * | 2018-01-08 | 2020-07-10 | 弘美制药（中国）有限公司 | A composition with oral cleaning and treating effects |
| CN108685989A (en) * | 2018-07-18 | 2018-10-23 | 黑龙江福和制药集团股份有限公司 | A kind of dandelion essence cream and its preparation method |
| CN109498524A (en) * | 2018-12-30 | 2019-03-22 | 广东新南方青蒿日化有限公司 | A kind of Chinese medicine compound prescription sweet wormwood toothpaste and preparation method thereof |
| CN109620774A (en) * | 2019-01-28 | 2019-04-16 | 荆楚理工学院 | A kind of herbal mixture care toothpaste and preparation method thereof |
| CN111388560A (en) * | 2020-04-16 | 2020-07-10 | 广东君道营养科技有限公司 | Traditional Chinese medicine composition for inhibiting formation of dental plaque, preparation method and application thereof |
| CN111956549A (en) * | 2020-08-27 | 2020-11-20 | 上海蔚艺生物科技有限公司 | Toothpaste with compatibility of plant essences and application of toothpaste |
| CN112716854A (en) * | 2021-01-27 | 2021-04-30 | 新乡博凯生物技术有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN112716854B (en) * | 2021-01-27 | 2022-12-13 | 新乡博凯生物技术有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN114832036A (en) * | 2022-05-13 | 2022-08-02 | 漳州无极药业有限公司 | Medicinal composition for treating gingivitis and preparation method thereof |
| CN114983898A (en) * | 2022-07-05 | 2022-09-02 | 贵州苗老藤化妆品生产制造有限公司 | Chinese herbal medicine toothpaste and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106937925A (en) | A kind of compound traditional Chinese medicine composite and toothpaste containing the compound traditional Chinese medicine composite and preparation method thereof | |
| CN100560054C (en) | Oral cleaning composition | |
| CN104666185B (en) | A kind of liquid tooth paste and preparation method thereof | |
| CN101380285B (en) | Bletilla striata Chinese herbal medicine toothpaste | |
| CN104188855B (en) | Traditional Chinese medicine toothpaste with effects of preventing and relieving tooth sensitivity | |
| CN102293725B (en) | Manufacture process for gargle used for oral cavity cleanness | |
| CN107184476A (en) | A kind of antibacterial mouthwash and preparation method thereof | |
| CN105055230A (en) | Multifunctional Chinese medicinal toothpaste composition, toothpaste prepared from composition and preparation method of toothpaste | |
| CN105310960B (en) | A kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof | |
| CN103536451A (en) | Traditional Chinese medicine toothpaste and preparation method thereof | |
| CN103536497B (en) | A kind of Traditional Chinese medicinal compound collutory and preparation method thereof | |
| CN107998036A (en) | A kind of toothpaste and its manufacture method for oral cavity synthtic price index | |
| CN107468553A (en) | A kind of anti-caries toothpaste | |
| CN106924106A (en) | A kind of toothpaste for suppressing bacterial plaque and mitigate gingivitis | |
| CN107811890A (en) | A kind of oral cavity caring toothpaste composition | |
| CN109528601A (en) | Herbal mixture mouthwash and preparation method thereof | |
| CN101007088A (en) | A traditional Chinese medicine composition for treating periodontal diseases and its preparation method | |
| CN102784209B (en) | Traditional Chinese medicine composition for preventing and treating tooth sensitivity, toothpaste and preparation method thereof | |
| CN107982192A (en) | A kind of draft nursing mouthwash of effectively removing taste | |
| CN1234389C (en) | Chinese traditional medicine for treating oral disease and its preparing process | |
| CN112076221B (en) | Desensitizing paste and preparation method and application thereof | |
| CN117100676A (en) | Toothpaste containing centella asiatica extract and probiotics and preparation method thereof | |
| CN107485584A (en) | A kind of oral care composition | |
| CN106692755A (en) | Traditional Chinese medicine composition with functions of stopping bleeding, eliminating inflammation and preventing bacteria and preparation method and application of traditional Chinese medicine composition | |
| CN112137928A (en) | Multi-effect toothpaste and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170711 |
|
| RJ01 | Rejection of invention patent application after publication |