CN109498524A - A kind of Chinese medicine compound prescription sweet wormwood toothpaste and preparation method thereof - Google Patents
A kind of Chinese medicine compound prescription sweet wormwood toothpaste and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The present invention relates to household chemicals technical fields, specifically a kind of Chinese medicine compound prescription sweet wormwood toothpaste and preparation method thereof, raw material including following weight number: Chinese medicine, toothpaste base-material, water, wherein traditional Chinese medicine ingredients are sweet wormwood, rhizoma imperatae, wild chrysanthemum, honeysuckle, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, pseudo-ginseng, dandelion, Radix zanthoxyli, peppermint, wherein toothpaste base ingredients are calcium carbonate, dicalcium phosphate dihydrate, hydrated silica, glycerol, propylene glycol, sorbierite, sanlose, xylitol, method of the invention can reduce the loss of medicinal material effective component to the maximum extent, especially with ultralow temperature pulverizing Chinese medicine material, so that the effective component in Chinese medicine avoids being degraded by high temperature destructible, medicinal material volatile oil scheme is extracted using leading；Finished product active constituent content prepared by the present invention is high, property is stable, is easy to save, and improves excessive internal heat peculiar smell, conditioning oral cavity balance, reduces oral bacteria, safeguards that the effect of gums healthy is better than existing Chinese medicine toothpaste.
Description
Technical field
The present invention relates to household chemicals technical field, specifically a kind of Chinese medicine compound prescription sweet wormwood toothpaste and preparation method thereof.
Background technique
According to records, after meal with the method that strong tea is gargled be Soviet Union the horizontal bar in the front of a carriage used as an armrest invent.He just writes in " Chou Chi notes ": " I has
One method, every food, are gargled with strong tea, are bored and are both gone out and taste are not known.Meat is sloughed between cog, the contracting that disappears, untired to find fault, and tooth is just
If this heavily fortified point of edge is close." the visible cleaning in Ancient Times in China for tooth, beauty, it just there has been relatively high requirement.And the young bird of toothpaste
Shape appeared in for two Song's periods.The producing principle of toothpaste and modern toothpaste are substantially similar at that time.They can be increased with green salt, gypsum
Toothpaste frictional force, refrigerant antibacterial with asarum wrinkled giant hyssop, sky-high price santal, clove bark increase toothpaste fragrance.
Sweet wormwood is conventional Chinese medicine, continues to use history what there were a two thousand years in China.It is used as medicine and sees the tomb of Han dynasty of Mawangdui three earliest
(B.C. 168 years or so) unearthed books copied on silk " 52 Bingfang ", are used for consumptive disease sore.Thereafter in Shennong's Herbal, " grand sight sheet
Grass " and Compendium of Material Medica etc. include.Before more than 1000 years, Eastern Jin Dynasty Ge Hong handbook of Prescription for Emergency head is carried to be cut with " sweet wormwood twists juice clothes "
Malaria.The modern age experiment of sweet wormwood in clinical research or be applied alone or with compound, treating abnormal heat, high fever, hot summer weather and unknown cause
Heat shows good therapeutic effect during suffering from.Flu, acute tonsillitis, rheumatoid arthritis, acute cholecystitis, function can be treated
Can a variety of febrile diseases such as property low-heat, clinic prompt Antifebrile Action of Herba Artemisiae it is applied widely, it is antipyretic that be not only inducing diaphoresis thoroughly evil,
But also with heat-clearing and fire-reducing, removing pattogenic heat from the blood and toxic material from the body, dampness elimination cholagogue, saturating network detumescence etc. functions it is related.
Sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint gomi herbs contain volatile oil component, and fragrant odour is pleasant.In
Volatile oil in medicine has the property of degerming bacteria resistance function, can improve periodontitis, and can improve the smell of toothpaste, exempt from adduction at
Essence.But traditional extracting technique of Chinese medicine uses and directly adds water to cook extraction, the direct evaporation loss of Constituents of The Essential Oil in medicinal material.
The preparation process of Chinese medicine class toothpaste substantially continues to use traditional process at present, and medicinal material is directly thrown without pre-treatment
Expect to use water boiling and extraction, effective component extraction rate is low in medicinal material, and decoction extraction time is long, and effective component is damaged and damaged
Lose, to influence the quality of toothpaste, effect, with the mankind to the continuous improvement of oral cavity health requirements and toothpaste making process not
Disconnected development, current technique have been unable to meet current demand, and a set of holding effective component of urgent need is higher, the smaller life of material loss
Production. art, preferably to play the shield tooth value of Chinese medicinal toothpaste.
Summary of the invention
The purpose of the present invention is to provide a kind of Chinese medicine compound prescription sweet wormwood toothpaste and preparation method thereof, to solve above-mentioned background skill
The problem of being proposed in art.
To achieve the above object, the invention provides the following technical scheme:
A kind of Chinese medicine compound prescription sweet wormwood toothpaste, the raw material including following parts by weight: 91-122 parts of Chinese medicine, toothpaste base-material 1000-
1300 parts, 1000-1200 parts of water, wherein Chinese medicine weight proportion is sweet wormwood 10-13 parts, 10-13 parts of rhizoma imperatae, wild chrysanthemum 10-13
Part, 2-4 parts of honeysuckle, 10-13 parts of honeysuckle herb, 5-7 parts of mulberry leaf, 5-7 parts of Radix Glycyrrhizae, 17-20 parts of Radix Isatidis, 1-3 parts of pseudo-ginseng,
10-13 parts of dandelion, 10-13 parts of Radix zanthoxyli, 1-3 parts of peppermint, wherein toothpaste base-material weight proportion be calcium carbonate 350-400 parts,
320-400 parts of dicalcium phosphate dihydrate, 210-270 parts of hydrated silica, 30-60 parts of glycerol, 50-60 parts of propylene glycol, sorbierite 10-30
Part, 10-30 parts of sanlose, 20-50 parts of xylitol.
Further, Chinese medicine weight proportion is sweet wormwood 11-12 parts, 11-12 parts of rhizoma imperatae, 11-12 parts of wild chrysanthemum, gold and silver
Flower 3-4 parts, 11-12 parts of honeysuckle herb, 6-7 parts of mulberry leaf, 6-7 parts of Radix Glycyrrhizae, 18-20 parts of Radix Isatidis, 2-3 parts of pseudo-ginseng, dandelion
11-12 parts, 11-13 parts of Radix zanthoxyli, 2-3 parts of peppermint, toothpaste base-material weight proportion are calcium carbonate 360-400 parts, hydrogen phosphate dihydrate
330-380 parts of calcium, 220-260 parts of hydrated silica, 40-50 parts of glycerol, 50-60 parts of propylene glycol, 20-30 parts of sorbierite, carboxymethyl
20-30 parts of cellulose sodium salt, 30-50 parts of xylitol.
Further, Chinese medicine weight proportion is 12 parts of sweet wormwood, 12 parts of rhizoma imperatae, 12 parts of wild chrysanthemum, 3 parts of honeysuckle, gold
12 parts of honeysuckle flower herb, 6 parts of mulberry leaf, 6 parts of Radix Glycyrrhizae, 18 parts of Radix Isatidis, 2 parts of pseudo-ginseng, 12 parts of dandelion, 12 parts of Radix zanthoxyli, peppermint 2
Part, wherein toothpaste base-material weight proportion is 380 parts of calcium carbonate, 350 parts of dicalcium phosphate dihydrate, 250 parts of hydrated silica, glycerol 45
Part, 55 parts of propylene glycol, 20 parts of sorbierite, 20 parts of sanlose, 30 parts of xylitol.
A kind of preparation method of Chinese medicine compound prescription sweet wormwood toothpaste, which comprises the following steps:
(1) it sprays liquid nitrogen and sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint is carried out to cooling embrittlement respectively, crushed with ultralow temperature
Machine crushes, and obtains coarse powder A, and the coarse powder A water for being uniformly mixed 2~4 times of its volume of addition is impregnated 1~1.5 hour and ultrasound mentions
It takes 30~50 minutes, is placed in volatile oil extracting tank and extracts 2~4 hours, obtain sweet wormwood Mixed chaotic sequences and dregs of a decoction A；
(2) it sprays liquid nitrogen and rhizoma imperatae, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion is carried out to cooling embrittlement respectively, use
Super-low temperature pulverizator crushes, and obtains coarse powder B, and coarse powder B and dregs of a decoction A is mixed, and the mass fraction that 2~4 times of its volume amounts are added is
95% alcohol reflux extracts 2 times, 2~4 hours every time, filtrate and the alcohol extracting dregs of a decoction is obtained by filtration, merging filtrate is true using decompression
Sky is concentrated to get the extractum A that relative density is 1.0~1.2, the alcohol extracting dregs of a decoction is added 2~4 times of its volume water measured decoctions 2 times, often
Secondary decocting time is 1~2 hour, merges decoction liquor, filtering, and decoction liquor uses reduced vacuum to be concentrated to get relative density as 1.0
~1.2 medicinal extract B carries out extractum A and medicinal extract B to be mixed to get medicinal extract C；
(3) it spraying liquid nitrogen and pseudo-ginseng is subjected to cooling embrittlement, be ground into superfine powder with super-low temperature pulverizator, sterilizing, is sieved at drying,
Obtain pseudo-ginseng superfine powder；
(4) sweet wormwood Mixed chaotic sequences, medicinal extract C and pseudo-ginseng superfine powder are poured into vacuum Manufacturing medicine extract machine, open vacuum, vacuum degree be-
0.04~-0.06MPa is stirred 30~60 minutes, and pseudo-ginseng superfine powder discharge air is allowed to fully absorb moisture in medicinal extract C, then plus
Enter calcium carbonate, dicalcium phosphate dihydrate, hydrated silica, glycerol, propylene glycol, sorbierite, sanlose, xylitol and
Water, open vacuum, vacuum degree be -0.4~-0.6MPa, stir 30~60 minutes, after mixing evenly, restore normal pressure to get.
Further, in step (1), sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint total weight and liquid nitrogen weight
Than for 5~40:1, sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint cooling embrittlement time be 2~6 minutes.
Further, in step (2), rhizoma imperatae, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion total weight
Be 1~50:1 with the weight ratio of liquid nitrogen, rhizoma imperatae, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion cooling embrittlement when
Between be 5~8 minutes, filtrate decompression vacuum concentration temperature be 60~80 DEG C, vacuum degree be -0.04~-0.085MPa.
Further, in step (3), the time of pseudo-ginseng cooling embrittlement is 8~10 minutes, the weight ratio of pseudo-ginseng and liquid nitrogen
For 1~5:1,3 pulse vacuum steriles are carried out to pseudo-ginseng superfine powder, sterilising temp is 121 DEG C, and sterilization time is 30 minutes, is done
The dry time is 10~15 minutes, and pseudo-ginseng superfine powder partial size is less than 10 μm.
Using technical solution provided by the invention, compared with prior art, method of the invention is had the following beneficial effects:
The loss that medicinal material effective component can be reduced to the maximum extent, especially with ultralow temperature pulverizing Chinese medicine material, so that in sweet wormwood
Qinghaosu and volatile oil, pseudo-ginseng saponin and ginsenoside in pseudo-ginseng, glycyrrhizin and glycyrrhizic acid in Radix Glycyrrhizae, in rhizoma imperatae
The effective components such as arundoin and Cylindrin are avoided by high temperature, extract medicinal material volatile oil scheme using leading；Present invention preparation
Finished product active constituent content it is high, property is stable, is easy to save, improve that excessive internal heat peculiar smell, conditioning oral cavity balance, to reduce oral cavity thin
Bacterium safeguards that the effect of gums healthy is better than other Chinese medicinal toothpastes of the prior art, remains sweet wormwood, wild chrysanthemum, honeysuckle, two sides
The aromatic odor of the medicinal materials such as needle, peppermint improves the fragrance of toothpaste, exempts to add compound essence, improves the shield tooth effect of product.
Specific embodiment
The technical solution of the patent is explained in further detail With reference to embodiment.
Embodiment 1
A kind of Chinese medicine compound prescription sweet wormwood toothpaste, including following raw material: traditional Chinese medicinal components be sweet wormwood 10g, rhizoma imperatae 10g, wild chrysanthemum 10g,
It is honeysuckle 2g, honeysuckle herb 10g, mulberry leaf 5g, Radix Glycyrrhizae 5g, Radix Isatidis 17g, pseudo-ginseng 1g, dandelion 10g, Radix zanthoxyli 10g, thin
Lotus 1g, toothpaste base ingredient are calcium carbonate 350g, dicalcium phosphate dihydrate 320g, hydrated silica 210g, glycerol 30g, propylene glycol
50g, sorbierite 10g, sanlose 10g, xylitol 20g.
A kind of preparation method of Chinese medicine compound prescription sweet wormwood toothpaste, which comprises the following steps:
(1) spray liquid nitrogen by sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint respectively carry out cooling embrittlement, sweet wormwood, wild chrysanthemum,
Honeysuckle, Radix zanthoxyli, peppermint total weight and liquid nitrogen weight ratio be 5:1, sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint drop
The time of warm embrittlement is 2 minutes, is crushed with super-low temperature pulverizator, obtains coarse powder A, coarse powder A is uniformly mixed, 2 times of its volume is added
Water impregnate 1 hour and ultrasonic extraction 30 minutes, be placed in volatile oil extracting tank and extract 2 hours, obtain sweet wormwood mixed volatilization
Oil and dregs of a decoction A；
(2) it sprays liquid nitrogen and rhizoma imperatae, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion is carried out to cooling embrittlement respectively, it is white
Lalang grass rhizome, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion total weight and liquid nitrogen weight ratio be 1:1, rhizoma imperatae, gold and silver
The time for spending herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion cooling brittle is 5 minutes, is crushed with super-low temperature pulverizator, is obtained thick
Powder B mixes coarse powder B and dregs of a decoction A, and the alcohol reflux that the mass fraction that 2 times of its volume amounts are added is 95% extracts 2 times, and every time 2
Hour, filtrate and the alcohol extracting dregs of a decoction is obtained by filtration, merging filtrate uses reduced vacuum to be concentrated to get relative density as 1.0 medicinal extract
The alcohol extracting dregs of a decoction are added the water of 2 times of its volume amounts to decoct 2 times by A, and each decocting time is 1 hour, merges decoction liquor, is filtered, and is decocted
Liquid uses reduced vacuum to be concentrated to get relative density as 1.0 medicinal extract B, and the temperature of filtrate decompression vacuum concentration is 60 DEG C, vacuum
Degree is -0.04MPa, carries out extractum A and medicinal extract B to be mixed to get medicinal extract C；
(3) it spraying liquid nitrogen and pseudo-ginseng is subjected to cooling embrittlement, be ground into superfine powder with super-low temperature pulverizator, sterilizing, is sieved at drying,
Pseudo-ginseng superfine powder is obtained, the time of pseudo-ginseng cooling embrittlement is 8 minutes, and the weight ratio of pseudo-ginseng and liquid nitrogen is 1:1, to pseudo-ginseng superfine powder
3 pulse vacuum steriles are carried out, sterilising temp is 121 DEG C, and sterilization time is 30 minutes, and drying time is 10 minutes, and pseudo-ginseng is super
Fine powder partial size is less than 10 μm；
(4) sweet wormwood Mixed chaotic sequences, medicinal extract C and pseudo-ginseng superfine powder are poured into vacuum Manufacturing medicine extract machine, open vacuum, vacuum degree be-
0.04MPa is stirred 30 minutes, is allowed pseudo-ginseng superfine powder discharge air to fully absorb the moisture in medicinal extract C, is added calcium carbonate, two
Water calcium monohydrogen phosphate, hydrated silica, glycerol, propylene glycol, sorbierite, sanlose, xylose alcohol and water open vacuum,
Vacuum degree be -0.4MPa, stir 30 minutes, after mixing evenly, restore normal pressure to get.
Embodiment 2
A kind of Chinese medicine compound prescription sweet wormwood toothpaste, including following raw material: traditional Chinese medicinal components be sweet wormwood 13g, rhizoma imperatae 13g, wild chrysanthemum 13g,
It is honeysuckle 4g, honeysuckle herb 13g, mulberry leaf 7g, Radix Glycyrrhizae 7g, Radix Isatidis 20g, pseudo-ginseng 3g, dandelion 13g, Radix zanthoxyli 13g, thin
Lotus 3g, toothpaste base ingredient are calcium carbonate 400g, dicalcium phosphate dihydrate 400g, hydrated silica 270g, glycerol 60g, propylene glycol
60g, sorbierite 30g, sanlose 30g, xylitol 50g.
A kind of preparation method of Chinese medicine compound prescription sweet wormwood toothpaste, which comprises the following steps:
(1) spray liquid nitrogen by sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint respectively carry out cooling embrittlement, sweet wormwood, wild chrysanthemum,
Honeysuckle, Radix zanthoxyli, peppermint total weight and liquid nitrogen weight ratio be 40:1, sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint drop
The time of warm embrittlement is 6 minutes, is crushed with super-low temperature pulverizator, obtains coarse powder A, coarse powder A is uniformly mixed, 4 times of its volume is added
Water impregnate 1.5 hours and ultrasonic extraction 50 minutes, be placed in volatile oil extracting tank and extract 4 hours, obtain sweet wormwood mix wave
Hair oil and dregs of a decoction A；
(2) it sprays liquid nitrogen and rhizoma imperatae, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion is carried out to cooling embrittlement respectively, it is white
Lalang grass rhizome, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion total weight and liquid nitrogen weight ratio be 50:1, rhizoma imperatae, gold and silver
The time for spending herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion cooling brittle is 8 minutes, is crushed with super-low temperature pulverizator, is obtained thick
Powder B mixes coarse powder B and dregs of a decoction A, and the alcohol reflux that the mass fraction that 4 times of its volume amounts are added is 95% extracts 2 times, and every time 4
Hour, filtrate and the alcohol extracting dregs of a decoction is obtained by filtration, merging filtrate uses reduced vacuum to be concentrated to get relative density as 1.2 medicinal extract
The alcohol extracting dregs of a decoction are added the water of 4 times of its volume amounts to decoct 2 times by A, and each decocting time is 2 hours, merges decoction liquor, is filtered, and is decocted
Liquid uses reduced vacuum to be concentrated to get relative density as 1.2 medicinal extract B, and the temperature of filtrate decompression vacuum concentration is 80 DEG C, vacuum
Degree is -0.085MPa, carries out extractum A and medicinal extract B to be mixed to get medicinal extract C；
(3) it spraying liquid nitrogen and pseudo-ginseng is subjected to cooling embrittlement, be ground into superfine powder with super-low temperature pulverizator, sterilizing, is sieved at drying,
Pseudo-ginseng superfine powder is obtained, the time of pseudo-ginseng cooling embrittlement is 10 minutes, and the weight ratio of pseudo-ginseng and liquid nitrogen is 5:1, ultra-fine to pseudo-ginseng
Powder carries out 3 pulse vacuum steriles, and sterilising temp is 121 DEG C, and sterilization time is 30 minutes, and drying time is 15 minutes, pseudo-ginseng
Superfine powder partial size is less than 10 μm；
(4) sweet wormwood Mixed chaotic sequences, medicinal extract C and pseudo-ginseng superfine powder are poured into vacuum Manufacturing medicine extract machine, open vacuum, vacuum degree be-
0.06MPa is stirred 60 minutes, is allowed pseudo-ginseng superfine powder discharge air to fully absorb the moisture in medicinal extract C, is added calcium carbonate, two
Water calcium monohydrogen phosphate, hydrated silica, glycerol, propylene glycol, sorbierite, sanlose, xylose alcohol and water open vacuum,
Vacuum degree be -0.6MPa, stir 60 minutes, after mixing evenly, restore normal pressure to get.
Embodiment 3
A kind of Chinese medicine compound prescription sweet wormwood toothpaste, including following raw material: traditional Chinese medicinal components be sweet wormwood 11g, rhizoma imperatae 11g, wild chrysanthemum 11g,
It is honeysuckle 3g, honeysuckle herb 11g, mulberry leaf 6g, Radix Glycyrrhizae 6g, Radix Isatidis 18g, pseudo-ginseng 2g, dandelion 11g, Radix zanthoxyli 11g, thin
Lotus 2g, toothpaste base ingredient are calcium carbonate 360g, dicalcium phosphate dihydrate 330g, hydrated silica 220g, glycerol 40g, propylene glycol
50g, sorbierite 20g, sanlose 20g, xylitol 30g.
A kind of preparation method of Chinese medicine compound prescription sweet wormwood toothpaste, which comprises the following steps:
(1) spray liquid nitrogen by sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint respectively carry out cooling embrittlement, sweet wormwood, wild chrysanthemum,
Honeysuckle, Radix zanthoxyli, peppermint total weight and liquid nitrogen weight ratio be 15:1, sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint drop
The time of warm embrittlement is 3 minutes, is crushed with super-low temperature pulverizator, obtains coarse powder A, coarse powder A is uniformly mixed, its volume 2.5 is added
Water again impregnates 1.2 hours and ultrasonic extraction 35 minutes, is placed in volatile oil extracting tank and extracts 2.5 hours, and it is mixed to obtain sweet wormwood
Close volatile oil and dregs of a decoction A；
(2) it sprays liquid nitrogen and rhizoma imperatae, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion is carried out to cooling embrittlement respectively, it is white
Lalang grass rhizome, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion total weight and liquid nitrogen weight ratio be 20:1, rhizoma imperatae, gold and silver
The time for spending herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion cooling brittle is 6 minutes, is crushed with super-low temperature pulverizator, is obtained thick
Powder B mixes coarse powder B and dregs of a decoction A, the alcohol reflux extraction that the mass fraction that 2.5 times of its volume amounts are added is 95% 2 times, every time
2.5 hours, filtrate and the alcohol extracting dregs of a decoction is obtained by filtration, merging filtrate uses reduced vacuum to be concentrated to get relative density as 1.1 leaching
The alcohol extracting dregs of a decoction are added the water of 2.5 times of its volume amounts to decoct 2 times by cream A, and each decocting time is 1.2 hours, merges decoction liquor, mistake
Filter, decoction liquor use reduced vacuum to be concentrated to get relative density as 1.1 medicinal extract B, and the temperature of filtrate decompression vacuum concentration is 65
DEG C, vacuum degree is -0.05MPa, carries out extractum A and medicinal extract B to be mixed to get medicinal extract C；
(3) it spraying liquid nitrogen and pseudo-ginseng is subjected to cooling embrittlement, be ground into superfine powder with super-low temperature pulverizator, sterilizing, is sieved at drying,
Pseudo-ginseng superfine powder is obtained, the time of pseudo-ginseng cooling embrittlement is 9 minutes, and the weight ratio of pseudo-ginseng and liquid nitrogen is 2:1, to pseudo-ginseng superfine powder
3 pulse vacuum steriles are carried out, sterilising temp is 121 DEG C, and sterilization time is 30 minutes, and drying time is 11 minutes, and pseudo-ginseng is super
Fine powder partial size is less than 10 μm；
(4) sweet wormwood Mixed chaotic sequences, medicinal extract C and pseudo-ginseng superfine powder are poured into vacuum Manufacturing medicine extract machine, open vacuum, vacuum degree be-
0.05MPa is stirred 40 minutes, is allowed pseudo-ginseng superfine powder discharge air to fully absorb the moisture in medicinal extract C, is added calcium carbonate, two
Water calcium monohydrogen phosphate, hydrated silica, glycerol, propylene glycol, sorbierite, sanlose, xylose alcohol and water open vacuum,
Vacuum degree be -0.5MPa, stir 40 minutes, after mixing evenly, restore normal pressure to get.
Embodiment 4
A kind of Chinese medicine compound prescription sweet wormwood toothpaste, including following raw material: traditional Chinese medicinal components be sweet wormwood 12g, rhizoma imperatae 12g, wild chrysanthemum 12g,
It is honeysuckle 4g, honeysuckle herb 12g, mulberry leaf 7g, Radix Glycyrrhizae 7g, Radix Isatidis 20g, pseudo-ginseng 3g, dandelion 12g, Radix zanthoxyli 13g, thin
Lotus 3g, toothpaste base ingredient are calcium carbonate 400g, dicalcium phosphate dihydrate 380g, hydrated silica 260g, glycerol 50g, propylene glycol
60g, sorbierite 30g, sanlose 30g, xylitol 50g.
A kind of preparation method of Chinese medicine compound prescription sweet wormwood toothpaste, which comprises the following steps:
(1) spray liquid nitrogen by sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint respectively carry out cooling embrittlement, sweet wormwood, wild chrysanthemum,
Honeysuckle, Radix zanthoxyli, peppermint total weight and liquid nitrogen weight ratio be 30:1, sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint drop
The time of warm embrittlement is 5 minutes, is crushed with super-low temperature pulverizator, obtains coarse powder A, coarse powder A is uniformly mixed, its volume 3.5 is added
Water again impregnates 1.4 hours and ultrasonic extraction 45 minutes, is placed in volatile oil extracting tank and extracts 3.5 hours, and it is mixed to obtain sweet wormwood
Close volatile oil and dregs of a decoction A；
(2) it sprays liquid nitrogen and rhizoma imperatae, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion is carried out to cooling embrittlement respectively, it is white
Lalang grass rhizome, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion total weight and liquid nitrogen weight ratio be 40:1, rhizoma imperatae, gold and silver
The time for spending herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion cooling brittle is 7 minutes, is crushed with super-low temperature pulverizator, is obtained thick
Powder B mixes coarse powder B and dregs of a decoction A, the alcohol reflux extraction that the mass fraction that 3.5 times of its volume amounts are added is 95% 2 times, every time
3.5 hours, filtrate and the alcohol extracting dregs of a decoction is obtained by filtration, merging filtrate uses reduced vacuum to be concentrated to get relative density as 1.1 leaching
The alcohol extracting dregs of a decoction are added the water of 3.5 times of its volume amounts to decoct 2 times by cream A, and each decocting time is 1.8 hours, merges decoction liquor, mistake
Filter, decoction liquor use reduced vacuum to be concentrated to get relative density as 1.1 medicinal extract B, and the temperature of filtrate decompression vacuum concentration is 75
DEG C, vacuum degree is -0.07MPa, carries out extractum A and medicinal extract B to be mixed to get medicinal extract C；
(3) it spraying liquid nitrogen and pseudo-ginseng is subjected to cooling embrittlement, be ground into superfine powder with super-low temperature pulverizator, sterilizing, is sieved at drying,
Pseudo-ginseng superfine powder is obtained, the time of pseudo-ginseng cooling embrittlement is 9 minutes, and the weight ratio of pseudo-ginseng and liquid nitrogen is 4:1, to pseudo-ginseng superfine powder
3 pulse vacuum steriles are carried out, sterilising temp is 121 DEG C, and sterilization time is 30 minutes, and drying time is 14 minutes, and pseudo-ginseng is super
Fine powder partial size is less than 10 μm；
(4) sweet wormwood Mixed chaotic sequences, medicinal extract C and pseudo-ginseng superfine powder are poured into vacuum Manufacturing medicine extract machine, open vacuum, vacuum degree be-
0.05MPa is stirred 55 minutes, is allowed pseudo-ginseng superfine powder discharge air to fully absorb the moisture in medicinal extract C, is added calcium carbonate, two
Water calcium monohydrogen phosphate, hydrated silica, glycerol, propylene glycol, sorbierite, sanlose, xylose alcohol and water open vacuum,
Vacuum degree be -0.5MPa, stir 55 minutes, after mixing evenly, restore normal pressure to get.
Embodiment 5
A kind of Chinese medicine compound prescription sweet wormwood toothpaste, including following raw material: traditional Chinese medicinal components be sweet wormwood 12g, rhizoma imperatae 12g, wild chrysanthemum 12g,
It is honeysuckle 3g, honeysuckle herb 12g, mulberry leaf 6g, Radix Glycyrrhizae 6g, Radix Isatidis 18g, pseudo-ginseng 2g, dandelion 12g, Radix zanthoxyli 12g, thin
Lotus 2g, toothpaste base ingredient are calcium carbonate 380g, dicalcium phosphate dihydrate 350g, hydrated silica 250g, glycerol 45g, propylene glycol
55g, sorbierite 20g, sanlose 20g, xylitol 30g.
A kind of preparation method of Chinese medicine compound prescription sweet wormwood toothpaste, which comprises the following steps:
(1) spray liquid nitrogen by sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint respectively carry out cooling embrittlement, sweet wormwood, wild chrysanthemum,
Honeysuckle, Radix zanthoxyli, peppermint total weight and liquid nitrogen weight ratio be 20:1, sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint drop
The time of warm embrittlement is 4 minutes, is crushed with super-low temperature pulverizator, obtains coarse powder A, coarse powder A is uniformly mixed, 3 times of its volume is added
Water impregnate 1.3 hours and ultrasonic extraction 40 minutes, be placed in volatile oil extracting tank and extract 3 hours, obtain sweet wormwood mix wave
Hair oil and dregs of a decoction A；
(2) it sprays liquid nitrogen and rhizoma imperatae, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion is carried out to cooling embrittlement respectively, it is white
Lalang grass rhizome, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion total weight and liquid nitrogen weight ratio be 25:1, rhizoma imperatae, gold and silver
The time for spending herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion cooling brittle is 6 minutes, is crushed with super-low temperature pulverizator, is obtained thick
Powder B mixes coarse powder B and dregs of a decoction A, and the alcohol reflux that the mass fraction that 3 times of its volume amounts are added is 95% extracts 2 times, and every time 3
Hour, filtrate and the alcohol extracting dregs of a decoction is obtained by filtration, merging filtrate uses reduced vacuum to be concentrated to get relative density as 1.1 medicinal extract
The alcohol extracting dregs of a decoction are added the water of 3 times of its volume amounts to decoct 2 times by A, and each decocting time is 1.5 hours, merges decoction liquor, is filtered, and is decocted
Boil liquid uses reduced vacuum to be concentrated to get relative density as 1.1 medicinal extract B, and the temperature of filtrate decompression vacuum concentration is 70 DEG C, very
Reciprocal of duty cycle is -0.06MPa, carries out extractum A and medicinal extract B to be mixed to get medicinal extract C；
(3) it spraying liquid nitrogen and pseudo-ginseng is subjected to cooling embrittlement, be ground into superfine powder with super-low temperature pulverizator, sterilizing, is sieved at drying,
Pseudo-ginseng superfine powder is obtained, the time of pseudo-ginseng cooling embrittlement is 9 minutes, and the weight ratio of pseudo-ginseng and liquid nitrogen is 3:1, to pseudo-ginseng superfine powder
3 pulse vacuum steriles are carried out, sterilising temp is 121 DEG C, and sterilization time is 30 minutes, and drying time is 12 minutes, and pseudo-ginseng is super
Fine powder partial size is less than 10 μm；
(4) sweet wormwood Mixed chaotic sequences, medicinal extract C and pseudo-ginseng superfine powder are poured into vacuum Manufacturing medicine extract machine, open vacuum, vacuum degree be-
0.05MPa is stirred 50 minutes, is allowed pseudo-ginseng superfine powder discharge air to fully absorb the moisture in medicinal extract C, is added calcium carbonate, two
Water calcium monohydrogen phosphate, hydrated silica, glycerol, propylene glycol, sorbierite, sanlose, xylose alcohol and water open vacuum,
Vacuum degree be -0.5MPa, stir 50 minutes, after mixing evenly, restore normal pressure to get.
The preferred embodiment of the patent is described in detail above, but this patent is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be under the premise of not departing from this patent objective
Various changes can be made.
Claims (7)
1. a kind of Chinese medicine compound prescription sweet wormwood toothpaste, which is characterized in that the raw material including following parts by weight: 91-122 parts of Chinese medicine, tooth
1000-1300 parts of cream base material, 1000-1200 parts of water, wherein Chinese medicine weight proportion be sweet wormwood 10-13 parts, 10-13 parts of rhizoma imperatae,
10-13 parts of wild chrysanthemum, 2-4 parts of honeysuckle, 10-13 parts of honeysuckle herb, 5-7 parts of mulberry leaf, 5-7 parts of Radix Glycyrrhizae, Radix Isatidis 17-20
Part, 1-3 parts of pseudo-ginseng, 10-13 parts of dandelion, 10-13 parts of Radix zanthoxyli, 1-3 parts of peppermint, wherein toothpaste base-material weight proportion is carbonic acid
350-400 parts of calcium, 320-400 parts of dicalcium phosphate dihydrate, 210-270 parts of hydrated silica, 30-60 parts of glycerol, propylene glycol 50-60
Part, 10-30 parts of sorbierite, 10-30 parts of sanlose, 20-50 parts of xylitol.
2. Chinese medicine compound prescription sweet wormwood toothpaste according to claim 1, which is characterized in that Chinese medicine weight proportion is sweet wormwood 11-12
Part, 11-12 parts of rhizoma imperatae, 11-12 parts of wild chrysanthemum, 3-4 parts of honeysuckle, 11-12 parts of honeysuckle herb, 6-7 parts of mulberry leaf, Radix Glycyrrhizae 6-
7 parts, 18-20 parts of Radix Isatidis, 2-3 parts of pseudo-ginseng, 11-12 parts of dandelion, 11-13 parts of Radix zanthoxyli, 2-3 parts of peppermint, toothpaste base-material weight
Amount proportion for calcium carbonate 360-400 parts, 330-380 parts of dicalcium phosphate dihydrate, 220-260 parts of hydrated silica, 40-50 parts of glycerol,
50-60 parts of propylene glycol, 20-30 parts of sorbierite, 20-30 parts of sanlose, 30-50 parts of xylitol.
3. Chinese medicine compound prescription sweet wormwood toothpaste according to claim 1, which is characterized in that Chinese medicine weight proportion be 12 parts of sweet wormwood,
12 parts of rhizoma imperatae, 12 parts of wild chrysanthemum, 3 parts of honeysuckle, 12 parts of honeysuckle herb, 6 parts of mulberry leaf, 6 parts of Radix Glycyrrhizae, 18 parts of Radix Isatidis, field
72 parts, 12 parts of dandelion, 12 parts of Radix zanthoxyli, 2 parts of peppermint, wherein toothpaste base-material weight proportion is 380 parts of calcium carbonate, two water phosphorus
350 parts of sour hydrogen calcium, 250 parts of hydrated silica, 45 parts of glycerol, 55 parts of propylene glycol, 20 parts of sorbierite, sanlose 20
Part, 30 parts of xylitol.
4. a kind of preparation method of Chinese medicine compound prescription sweet wormwood toothpaste according to claim 1 to 3, which is characterized in that including
Following steps:
(1) it sprays liquid nitrogen and sweet wormwood, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint is carried out to cooling embrittlement respectively, crushed with ultralow temperature
Machine crushes, and obtains coarse powder A, and the coarse powder A water for being uniformly mixed 2~4 times of its volume of addition is impregnated 1~1.5 hour and ultrasound mentions
It takes 30~50 minutes, is placed in volatile oil extracting tank and extracts 2~4 hours, obtain sweet wormwood Mixed chaotic sequences and dregs of a decoction A；
(2) it sprays liquid nitrogen and rhizoma imperatae, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion is carried out to cooling embrittlement respectively, use
Super-low temperature pulverizator crushes, and obtains coarse powder B, and coarse powder B and dregs of a decoction A is mixed, and the mass fraction that 2~4 times of its volume amounts are added is
95% alcohol reflux extracts 2 times, 2~4 hours every time, filtrate and the alcohol extracting dregs of a decoction is obtained by filtration, merging filtrate is true using decompression
Sky is concentrated to get the extractum A that relative density is 1.0~1.2, the alcohol extracting dregs of a decoction is added 2~4 times of its volume water measured decoctions 2 times, often
Secondary decocting time is 1~2 hour, merges decoction liquor, filtering, and decoction liquor uses reduced vacuum to be concentrated to get relative density as 1.0
~1.2 medicinal extract B carries out extractum A and medicinal extract B to be mixed to get medicinal extract C；
(3) it spraying liquid nitrogen and pseudo-ginseng is subjected to cooling embrittlement, be ground into superfine powder with super-low temperature pulverizator, sterilizing, is sieved at drying,
Obtain pseudo-ginseng superfine powder；
(4) sweet wormwood Mixed chaotic sequences, medicinal extract C and pseudo-ginseng superfine powder are poured into vacuum Manufacturing medicine extract machine, open vacuum, vacuum degree be-
0.04~-0.06MPa is stirred 30~60 minutes, and pseudo-ginseng superfine powder discharge air is allowed to fully absorb moisture in medicinal extract C, then plus
Enter calcium carbonate, dicalcium phosphate dihydrate, hydrated silica, glycerol, propylene glycol, sorbierite, sanlose, xylitol and
Water, open vacuum, vacuum degree be -0.4~-0.6MPa, stir 30~60 minutes, after mixing evenly, restore normal pressure to get.
5. the preparation method of Chinese medicine compound prescription sweet wormwood toothpaste according to claim 4, which is characterized in that green in step (1)
Wormwood artemisia, wild chrysanthemum, honeysuckle, Radix zanthoxyli, peppermint total weight and liquid nitrogen weight ratio be 5~40:1, sweet wormwood, wild chrysanthemum, honeysuckle,
Radix zanthoxyli, peppermint the cooling brittle time are 2~6 minutes.
6. the preparation method of Chinese medicine compound prescription sweet wormwood toothpaste according to claim 4, which is characterized in that in step (2), cogongrass
Root, honeysuckle herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion total weight and liquid nitrogen weight ratio be 1~50:1, rhizoma imperatae, gold
Honeysuckle flower herb, mulberry leaf, Radix Glycyrrhizae, Radix Isatidis, dandelion the cooling brittle time are 5~8 minutes, the temperature of filtrate decompression vacuum concentration
Degree is 60~80 DEG C, and vacuum degree is -0.04~-0.085MPa.
7. the preparation method of Chinese medicine compound prescription sweet wormwood toothpaste according to claim 4, which is characterized in that in step (3), pseudo-ginseng
The time of cooling embrittlement is 8~10 minutes, and the weight ratio of pseudo-ginseng and liquid nitrogen is 1~5:1, carries out 3 pulsation to pseudo-ginseng superfine powder
Vacuum sterilization, sterilising temp are 121 DEG C, and sterilization time is 30 minutes, and drying time is 10~15 minutes, pseudo-ginseng superfine powder partial size
Less than 10 μm.
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