CN112138096A - Pharmaceutical composition for scalp health care, hair blacking and hair growth, preparation method and application thereof - Google Patents

Pharmaceutical composition for scalp health care, hair blacking and hair growth, preparation method and application thereof Download PDF

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CN112138096A
CN112138096A CN202011060594.7A CN202011060594A CN112138096A CN 112138096 A CN112138096 A CN 112138096A CN 202011060594 A CN202011060594 A CN 202011060594A CN 112138096 A CN112138096 A CN 112138096A
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pharmaceutical composition
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hair growth
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蒋文杰
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/14Cupressaceae (Cypress family), e.g. juniper or cypress
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

The invention discloses a pharmaceutical composition for scalp health care, hair blacking and hair growth, and a preparation method and application thereof. Preferably, it comprises by weight: 15 g of cogongrass rhizome, 12 g of cacumen biotae, 30 g of dandelion, 13 g of fleece-flower root and 8 g of dried rehmannia root. The composition also comprises herba Menthae, flos Lonicerae, and cortex Dictamni Radicis. Preferably, the composition also comprises 10 grams of mint, 8 grams of honeysuckle and 8 grams of dittany bark by weight. The invention also provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition for scalp health care, hair blacking and hair growth provided by the invention has no side effect and quick response, and can achieve the effects of reducing alopecia and white hair and removing trichophyton and the like by continuous use.

Description

Pharmaceutical composition for scalp health care, hair blacking and hair growth, preparation method and application thereof
Technical Field
The invention relates to a pharmaceutical composition in the fields of traditional Chinese medicine health care and biotechnology, a preparation method and application thereof, in particular to a pharmaceutical composition for scalp health care, hair blacking and hair growth, a preparation method and application thereof.
Background
The scalp is used as soil for hair to live, and the balance of ecological environment is the root of healthy growth of hair. The scalp is one of the thickest skins of the human body and is rich in blood vessels; the aging speed is 6 times of that of facial skin and 12 times of that of body skin. With the increasing social pressure and the accelerating pace of life, the environment is continuously worsened, poor dietary habits and unhealthy scalp are more and more, and the problems of tinea capitis, white hair, alopecia and the like are brought along.
One end of the hair looks young with thick and black hair, and by adding charm and spirit, the hair of some people looks dry, withered and yellow, or thin and cheerful, even a great amount of white hair appears, and a feeling of not aging before the old is given to people. It should be understood that human hair reflects more the health and nutrient balance or deficiency of human in addition to genetic factors.
White disease can be divided into congenital and acquired diseases. Congenital poliosis is accompanied with albinism at the same time, sometimes occurs in some hereditary diseases patients, such as ataxia-telangiectasia syndrome, and the like, and is characterized by familial inheritance. In addition to senile poliosis, premature poliosis is common in acquired poliosis, which may be genetically related, but also is an important factor for mental trauma, emotional agitation, pessimistic depression, malnutrition, and the like. Sometimes one of the symptoms of certain diseases, such as the insufficiency of the adrenal cortex.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition, a preparation method and application thereof, which can solve the existing problems, have no side effect and quick response after clinical effect verification, and can achieve the effects of reducing alopecia and white hair and removing the effects of trichophyton and the like after continuous use.
In order to achieve the purpose, the invention provides a pharmaceutical composition for scalp health care, hair blackening and hair growth, wherein the composition comprises lalang grass rhizome, cacumen biotae, dandelion, fleece-flower root and radix rehmanniae.
The pharmaceutical composition for scalp health care, hair blacking and hair growth comprises the following components in parts by weight: 14-18 parts of cogongrass rhizome, 10-15 parts of cacumen biotae, 25-35 parts of dandelion, 10-15 parts of fleece-flower root and 5-10 parts of radix rehmanniae.
The pharmaceutical composition for scalp health care, hair blacking and hair growth comprises the following components in parts by weight: 15 g of cogongrass rhizome, 12 g of cacumen biotae, 30 g of dandelion, 13 g of fleece-flower root and 8 g of dried rehmannia root.
The pharmaceutical composition for scalp health care, hair blacking and hair growth, wherein the composition further comprises mint, honeysuckle and dittany bark.
The pharmaceutical composition for scalp health care, hair blacking and hair growth is characterized by further comprising 8-12 parts by weight of mint, 5-10 parts by weight of honeysuckle and 5-10 parts by weight of dittany bark.
The pharmaceutical composition for scalp health care, hair blacking and hair growth, wherein the composition further comprises 10 g of mint, 8 g of honeysuckle and 8 g of dittany bark by weight.
The invention also provides a preparation method of the pharmaceutical composition for scalp health care, hair blacking and hair growth, wherein the method comprises the following steps: weighing the medicines in proportion, grinding and crushing after cleaning, adding water for decoction, extracting liquid medicine, and preserving for later use.
The preparation method of the pharmaceutical composition for scalp health care, hair blacking and hair growth comprises the step of grinding and crushing, wherein the particle size range is 20-30 meshes.
The preparation method of the pharmaceutical composition for scalp health care, hair blackening and hair growth comprises the steps of adding distilled water which is 10-16 times of the amount of the crushed medicinal materials into the crushed medicinal materials, heating and decocting for 40-60 min, filtering the extracted liquid medicine, and cooling and storing for later use.
The invention also provides the application of the pharmaceutical composition prepared by the method, wherein the pharmaceutical composition is used for preparing scalp washing liquor.
The pharmaceutical composition for scalp health care, hair blacking and hair growth, the preparation method and the application thereof provided by the invention have the following advantages:
the pharmaceutical composition provided by the invention has the characteristics of reasonable formula, small dosage, obvious effect, no toxic or side effect and the like.
The medicinal composition can be used as lotion for blackening white hair, and can be used for repairing and nourishing scalp cells. The raw materials are simple and easy to obtain, and the problem of high cost of the existing scalp moss medicament can be solved. The dandelion in the component has blackening effect after being oxidized, is beneficial to generating melanin, has the effect of guiding the lalang grass rhizome, can blacken the white hair, is beneficial to hair growth and scalp cell repair, and can treat the scalp moss in a targeted manner, thereby relieving the physiological pain and psychological burden of people suffering from the white hair, alopecia, tinea capitis and the like.
Detailed Description
The following further describes embodiments of the present invention.
The invention provides a pharmaceutical composition for scalp health care, hair blacking and hair growth, which comprises lalang grass rhizome, cacumen biotae, dandelion, fleece-flower root and radix rehmanniae.
Preferably, the composition comprises, in parts by weight: 14-18 parts of cogongrass rhizome, 10-15 parts of cacumen biotae, 25-35 parts of dandelion, 10-15 parts of fleece-flower root and 5-10 parts of radix rehmanniae.
More preferably, the composition comprises by weight: 15 g of cogongrass rhizome, 12 g of cacumen biotae, 30 g of dandelion, 13 g of fleece-flower root and 8 g of dried rehmannia root.
The composition also comprises herba Menthae, flos Lonicerae, and cortex Dictamni Radicis.
Preferably, the composition further comprises 8-12 parts by weight of mint, 5-10 parts by weight of honeysuckle and 5-10 parts by weight of dittany bark.
More preferably, the composition further comprises 10 grams of mint, 8 grams of honeysuckle and 8 grams of dittany bark by weight.
Wherein the lalang grass rhizome is rhizome of Imperata cylindrica of Gramineae. Collected in spring and autumn, removed fibrous root and membranous leaf sheath, cleaned, dried in the sun, cut into segments and unprocessed. Sweet in nature and taste and cold in nature; it enters lung, stomach and bladder meridians. Has effects of cooling blood, stopping bleeding, clearing heat, promoting urination, clearing lung-heat and stomach-heat. It can be used for treating hemorrhage due to blood heat, edema, stranguria due to heat, jaundice, emesis due to stomach heat, and cough and asthma due to lung heat. The product can remarkably shorten bleeding and blood coagulation time, and its decoction and water infusion have diuretic effect, and have obvious effect after administration for 5-10 days; has inhibitory effect on pneumococcus, catacoccus, influenzae, Staphylococcus aureus, and Shigella flexneri and Song's dysentery bacillus, and has certain HBV virus resistance.
Arborvitae genus, cypress family, evergreen arbor. Arborvitae is a special product in China and is distributed in China except Qinghai and Xinjiang. The leaves and the branches are used as the medicine, and can heal and stop bleeding, promote urination and invigorate the stomach, detoxify and dissipate blood stasis; the seed has effects of tranquilizing, nourishing and strengthening. The folium Platycladi is dry branch tip and leaf of Platycladus orientalis of Cupressaceae. Collected in summer and autumn mostly and dried in the shade. Bitter, astringent and cold in nature. It enters lung, liver and spleen meridians. Has the effects of cooling blood, stopping bleeding, eliminating phlegm, relieving cough, promoting hair growth and blackening hair. Can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, metrostaxis, cough due to lung heat, alopecia due to blood heat, and premature gray hair.
Herba Taraxaci, herba Violae, herba Veronicae Didyma, and HUALANG. Perennial herb of Compositae. The head-shaped inflorescence, the seeds are provided with pompon formed by white crown hairs, and the pompon floats to a new place along with wind after the flowers bloom to inoculate new life. Distributed in northeast, east, China, southwest, Shanxi, Gansu, Qinghai, etc. The medicinal part is dry whole plant of Taraxacum mongolicum hand-Mazz, Taraxacum sinicum hand-Mazz or plants of the same genus of Compositae, picked from spring to autumn when the flower begins to bloom, removed impurities, cleaned, cut into segments, and dried. Bitter, sweet and cold in nature. It enters liver and stomach meridians. Has the effects of clearing away heat and toxic materials, relieving swelling, dispersing pathogenic accumulation, inducing diuresis, and treating stranguria. It is mainly used for furuncle, swelling and toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, stranguria with heat and pain, etc.
The fleece-flower root is prepared by using the fleece-flower root, is a processed product of the fleece-flower root, is bitter, sweet, astringent and slightly warm in nature, enters liver, heart and kidney channels, has the effects of nourishing liver and kidney, benefiting essence and blood, blackening beard and hair and strengthening muscles and bones, is mainly used for treating blood deficiency and sallow complexion, dizziness and tinnitus, early white beard and hair, soreness and weakness of waist and knees, limb numbness, metrorrhagia and metrostaxis and leukorrhagia, chronic malaria and body deficiency, hyperlipidemia and the like, and can be used for brightening and blackening hair.
The radix rehmanniae is also called radix rehmanniae, wild rehmanniae, mountain tobacco root, etc., and is the root tuber of rehmannia glutinosa Libosch of Scrophulariaceae. Sweet, bitter and cold in nature and taste; it enters heart, liver and kidney meridians. Has the effects of clearing heat, cooling blood, nourishing yin and promoting the production of body fluid. Can be used for treating heat entering nutrient-blood, crimson tongue with polydipsia, macula, hematemesis and epistaxis, yin deficiency with internal heat, bone steaming with internal heat, body fluid consumption with thirst, internal heat with diabetes, intestinal dryness with constipation.
Herba Menthae is Labiatae plant; widely distributed in all parts of the country, mostly grown beside the mountain wetland rivers, with transverse roots and underground roots, and is an aromatic crop with special economic value. The whole herb or leaf is used as the medicine. Removing old stems and impurities, slightly spraying clear water, slightly moistening, cutting into short segments, and drying at low temperature in time. Pungent taste and cool nature; entering lung and liver meridians; has the effects of dispelling wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing; can be used for treating wind-heat common cold, headache, sore throat, dyspepsia, flatulence, aphtha, toothache, scabies, urticaria, early stage of epidemic febrile disease, rubella pruritus, stagnation of qi due to depression of the liver, chest distress, and hypochondriac pain.
The flos Lonicerae is dried bud or flower with initial blossom of Lonicera Japonica Thunb, Lonicera hypoglauca Miq, Lonicera confusa or Lonicera dasystyla of Caprifoliaceae. Sweet in nature and taste and cold in nature; it enters lung, heart and stomach meridians. Has the effects of clearing away heat and toxic materials, and dispelling pathogenic wind and heat. It is mainly used for treating carbuncle, furuncle, wind-heat type affection, early stage of epidemic febrile disease, and dysentery with blood due to toxic heat.
The cortex Dictamni Radicis is bark of Moss alba (a perennial herbaceous plant of Rutaceae). Bitter and salty in nature and cold in nature. Enter spleen and stomach meridians. Has the effects of dispelling pathogenic wind, clearing heat, eliminating dampness, removing toxic substance and relieving itching. Can be used for treating hemorrhoid, wind-heat sore, scabies, tinea, skin prurigo, rheumatalgia, and jaundice.
The invention also provides a preparation method of the pharmaceutical composition for scalp health care, hair blacking and hair growth, which comprises the following steps: weighing the medicines in proportion, grinding and crushing after cleaning, adding water for decoction, extracting liquid medicine, and preserving for later use.
Preferably, the particle size of the grinding and crushing is in the range of 20-30 meshes.
The step of adding water to decoct and extract the liquid medicine is that firstly, the crushed medicinal materials are added with distilled water which is 10-16 times of the amount of the added medicinal materials according to the weight, then the mixture is heated and decocted for 40-60 min, the extracted liquid medicine is filtered, and the extracted liquid medicine is cooled and stored for later use.
The invention also provides the application of the pharmaceutical composition prepared by the method, and the pharmaceutical composition is used for preparing scalp washing liquid, is directly used in daily hair washing, is externally coated on the scalp and can be used for massaging in a matching way.
The pharmaceutical composition for scalp health care and hair blackening and growth of hair according to the present invention, the preparation method and the use thereof are further described in the following examples.
Examples 1 to 4
In each example, the pharmaceutical composition was prepared according to the raw material composition ratios shown in table 1 below. All the raw materials respectively accord with the corresponding national standards.
Table 1 formulation table of pharmaceutical compositions (by weight).
Raw materials Example 1 Example 2 Example 3 Example 4
Rhizoma Imperatae 15g 14g 18g 28g
Cacumen Platycladi 12g 10g 15g 20g
Dandelion 30g 25g 35g 50g
Fleece-flower root 13g 10g 15g 20g
Dried rehmannia root 8g 5g 10g 10g
Mint 10g 8g 12g 16g
Honeysuckle flower 8g 5g 12g 10g
Cortex Dictamni Radicis 8g 5g 10g 10g
The invention also provides a preparation method of the pharmaceutical composition of each embodiment and application of the prepared pharmaceutical composition of each embodiment.
The preparation method comprises the following steps: weighing the medicines according to a proportion, cleaning, grinding and crushing the medicines, wherein the granularity of the ground and crushed medicines is 20-30 meshes, adding distilled water which is 10-16 times of the amount of the added medicines by weight into the crushed medicines, heating and decocting for 40-60 min, filtering and extracting liquid medicine, and cooling and storing the liquid medicine for later use.
The pharmaceutical composition can be used for preparing scalp lotion, and can be directly used in daily hair washing, and applied on scalp for massage.
The pharmaceutical composition prepared by the embodiments of the invention is used for carrying out typing syndrome differentiation treatment clinical tests on thousands of users with alopecia, white hair and scalp moss, the effective rate can reach more than 97.4 percent, and the significant efficiency can reach more than 89.2 percent.
The pharmaceutical composition is a traditional Chinese medicine formula formed by the function and the main treatment of each medicine and the research according to modern Chinese medicine pharmacology through multiple cases of clinical tests, and has the characteristics of scientific and reasonable formula, simple and easy preparation method, easy popularization, short time, good effect, low cost, no adverse reaction and no side effect. Clinical effect proves that the effect can be obviously observed within one month after daily use, and the effects of obviously reducing alopecia and white hair, removing scalp moss, greatly relieving psychological and physiological pains of users, economic burden and the like after continuous use can be realized.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.

Claims (10)

1. A pharmaceutical composition for scalp health care, hair blacking and hair growth is characterized by comprising lalang grass rhizome, cacumen biotae, dandelion, fleece-flower root and radix rehmanniae.
2. The pharmaceutical composition for scalp health care, hair blacking and hair growth according to claim 1, which comprises the following components in parts by weight: 14-18 parts of cogongrass rhizome, 10-15 parts of cacumen biotae, 25-35 parts of dandelion, 10-15 parts of fleece-flower root and 5-10 parts of radix rehmanniae.
3. The pharmaceutical composition for scalp health care, hair blackening and hair growth according to claim 2, wherein said composition comprises by weight: 15 g of cogongrass rhizome, 12 g of cacumen biotae, 30 g of dandelion, 13 g of fleece-flower root and 8 g of dried rehmannia root.
4. The pharmaceutical composition for scalp health care, hair blacking and hair growth according to claim 1, further comprising peppermint, honeysuckle and dittany bark.
5. The pharmaceutical composition for scalp health care, hair blacking and hair growth according to claim 4, further comprising 8-12 parts by weight of mint, 5-10 parts by weight of honeysuckle and 5-10 parts by weight of dittany bark.
6. The pharmaceutical composition for scalp health care, hair blacking and hair growth according to claim 5, further comprising 10 g of mint, 8 g of honeysuckle and 8 g of dittany bark by weight.
7. A method for preparing the pharmaceutical composition for scalp health care, hair blacking and hair growth according to any one of claims 1 to 6, which comprises the following steps: weighing the medicines in proportion, grinding and crushing after cleaning, adding water for decoction, extracting liquid medicine, and preserving for later use.
8. The method for preparing a pharmaceutical composition for scalp health care, hair blackening and hair growth according to claim 7, wherein the particle size of the ground and crushed particles is in the range of 20-30 mesh.
9. The method for preparing the pharmaceutical composition for scalp health care, hair blackening and hair growth according to claim 7, wherein the decoction is prepared by adding distilled water 10-16 times of the amount of the crushed medicinal materials, heating and decocting for 40-60 min, filtering the decoction, and cooling for storage.
10. Use of a pharmaceutical composition prepared according to the method of claim 7 for the preparation of a scalp lotion.
CN202011060594.7A 2020-09-30 2020-09-30 Pharmaceutical composition for scalp health care, hair blacking and hair growth, preparation method and application thereof Pending CN112138096A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112891279A (en) * 2021-03-31 2021-06-04 李绍旭 Traditional Chinese medicine scalp care composition, preparation method and application thereof

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Application publication date: 20201229