CN108042384A - A kind of composition with oral cleaning and therapeutic efficiency - Google Patents
A kind of composition with oral cleaning and therapeutic efficiency Download PDFInfo
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- CN108042384A CN108042384A CN201810014412.9A CN201810014412A CN108042384A CN 108042384 A CN108042384 A CN 108042384A CN 201810014412 A CN201810014412 A CN 201810014412A CN 108042384 A CN108042384 A CN 108042384A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention relates to a kind of composition with oral cleaning and therapeutic efficiency, by weight, including following component：0.0001~2 part of sodium azulenesulfonate, 0.1~15 part of Baical Skullcap root P.E, 0.1~25 part of dandelion extract.Toothpaste or mouthwash can be further made in the composition.Composition provided by the present invention gives full play to the synergistic function between each ingredient using the different medical mechanism of each ingredient so that the composition of gained can mitigate gingivitis, accelerate canker sore healing, remove intraoral helicobacter pylori.
Description
Technical field
The invention belongs to the technical fields of daily chemical products, and in particular to a kind of combination with oral cleaning and therapeutic efficiency
Object.
Background technology
National Survey on epidemiological features finds that 70.87-92.43% Adult Groups suffer from different degrees of periodontitis.Tooth
Zhou Yan is the various diseases for being happened at Periodontal Supporting Tissue (cementum, alveolar bone, gum, parodontium).It is gum redness first,
Gingival mucosa permeability enhances, and has developed into diffusate, and easy bleeding after probe touching if obtained medical treatment not in time, can go out
Existing gingival atrophy, absorption of alveolar bone, periodontal bag formation, tooth mobility and displacement can also trigger periodontal to overflow dense, oral peculiar smell, most
After cause loss of tooth or pull out.Therefore, periodontosis is the main reason for triggering adult's loss of tooth.
Canker sore is the highest a kind of disease of incidence in oral keritonocytes, and common cold, indigestion, spirit are tight
The generation that situations such as opening, is gloomy not happy can accidentally cause this sick, is apt to occur in lip, cheek, lingual margin etc., equal at any position of mucous membrane
Can occur.The disease has the characteristics that periodical, recurrent and self limiting.
Meanwhile gingivitis and canker sore patient, provide place for the existence of helicobacter pylori, and helicobacter pylori
General propagate enters to propagate for mouth, after infecting helicobacter pylori, is generally present in the positions such as plaque, mucous membrane of mouth, gingival pocket, makes
After mouth infection, compound frowzy can be directly generated, triggers halitosis.After swallowing stomach with food or saliva, progressively send out
It opens up as chronic gastritis and gastric ulcer.
Therefore, it is far from being enough with common oral preparation, for prevention of gingivitis disease, canker sore and mouth infection
Helicobacter pylori can not only clean oral cavity, it is necessary to develop a kind of dental products, can also mitigate gingivitis, accelerate mouth
Chamber ulcer healing removes intraoral helicobacter pylori.
The content of the invention
Based on above-mentioned background technology, it is an object of the invention to provide a kind of combinations with oral cleaning and therapeutic efficiency
Object, by weight, the composition include following component：
0.0001~2 part of sodium azulenesulfonate
0.1~15 part of Baical Skullcap root P.E
0.1~25 part of dandelion extract；
Preferably, the composition, by weight, including following components：
0.05~1 part of sodium azulenesulfonate
1.5~9 parts of Baical Skullcap root P.E
1~12 part of dandelion extract.
Wherein, the sodium azulenesulfonate is on the molecular structure of Kessazulen, by being modified what is be prepared.The Azulene sulphur
Sour sodium has fabulous anti-inflammatory, antibacterial, antiallergy and the effect for promoting regeneration, can promote empyrosis wound surface, ulcer wound surface
Healing and granulation regeneration, while have solar heat protection, radiation protection, it is anti-chap etc. a variety of effects, can be used to treat various diseases, safety
Property it is high, therefore be widely used in various pharmaceutical preparations, the particularly treatment and prevention to skin and mouth disease, significant effect.
The Baical Skullcap root P.E includes flavone compound；Wherein, the scutelloside in the brass class compound, the Chinese are yellow
A kind of reed mentioned in ancient books glycosides, baicalein, the total amount of wogonin are not less than 85%；The Baical Skullcap root P.E can be used for damp and hot, hot summer weather chest tightness and emesis, wet
Hot feeling of fullness, rush down dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus etc..
Baical Skullcap root P.E of the present invention is the alcohol extract or water extract of radix scutellariae.
The dandelion extract includes taraxasterol (Taraxasterol), choline (Choline), synanthrin
(Inulin), pectin (Pectin)；Taraxol (Taraxol), stigmasterol (Stigmasterol), β-amyrin (β-
Amyrin), cupreol (β-Sitosterol), taraxerol (taraxerol), taraxacin (Taraxacerin), Pu
Public English bitter principle (Taraxacin) and vitamin A, vitamin B, Microbial biomass C；The dandelion extract has clearing heat and detoxicating, clear
The effect of swollen dissipating bind, inducing diuresis for treating strangurtia, while there is very strong killing to make to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus
With.
The dandelion extract that the present invention is taken is the alcohol extract or water extract of dandelion.
Above-mentioned sodium azulenesulfonate, Baical Skullcap root P.E, the mutual compatibility of dandelion extract three, synergistic effect；On this basis,
Ratio is further explored, it is found that obtained composition effect is significantly improved.
Present invention further propose that, further include honeysuckle, peppermint, rheum officinale, betel nut, Radix Glycyrrhizae, dent in above-mentioned composition
Bamboo water pipe, Radix Astragali, myrrh, purple daisy, Salvia japonica, Radix Angelicae Sinensis, Chinese herbaceous peony, cover plate, Jing Hua, Fructus Forsythiae, curcuma zedoary, rhizoma cyperi, Rhizoma Atractylodis Macrocephalae, Wu at Cortex Phellodendri
One or more in the fruit of medicinal cornel, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Notoginseng powder.
When above-mentioned composition further includes honeysuckle；By weight, the composition further includes honeysuckle 0.1~24
Part.
When above-mentioned composition further includes peppermint, rheum officinale, betel nut, Radix Glycyrrhizae；By weight, the composition further include as
Lower component：
The present invention provides a kind of preferred embodiment, the composition, by weight, including following component：
When above-mentioned composition further includes Herba portulacae, Radix Astragali, Cortex Phellodendri, myrrh, purple daisy, Salvia japonica, Radix Angelicae Sinensis, Chinese herbaceous peony, covers disk
When son, Jing Hua, Fructus Forsythiae, curcuma zedoary, rhizoma cyperi, Rhizoma Atractylodis Macrocephalae, evodia rutaecarpa, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Notoginseng powder；By weight, the composition is also
Including following component：
The present invention provides a kind of preferred embodiment, the composition, by weight, including following component：
Second object of the present invention is, provides a kind of toothpaste, and the toothpaste includes any of the above-described composition；
Preferably, the toothpaste further includes solvent and function additive, and the function additive is selected from rubbing agent, moisturizer, hair
Two or more in infusion, thickener, sweetener, essence, preservative, appearance modifying agents；
It is highly preferred that the function additive is made of following component：
Preferably, the rubbing agent is selected from silica, hypophosphite monohydrate hydrogen calcium, calcium phosphate dibasic anhydrous, calcium carbonate, hydroxide
One or more of aluminium, calcium pyrophosphate；
The moisturizer is selected from sorbierite, glycerine, propylene glycol, one or more of polyethylene glycol-8, butanediol；
The foaming agent is selected from lauryl sodium sulfate, sodium lauroyl sarcosine, sodium cocoyl glycinate, acyl glutamic acid
One or more of sodium, cocounut oil acyl methyl taurine sodium；
The thickener is selected from cellulose and its derivates, melon glue, sodium alginate, xanthans, guar gum hydroxypropyl three
One or more of ammonio methacrylate, carrageenan, locust tree fresh kidney beans；
The sweetener is selected from saccharin sodium, Sucralose, xylitol, honey element, Aspartame, stevioside, sweet Momordica grosvenori
One or more of glycosides；
The essence is selected from one or more of vanilla, spearmint, minty note, Chinese ilex peppermint；
The preservative is selected from one or more of benzoic acid and its esters, sorbic acid and its esters, parabens；
The appearance modifying agents are selected from titanium dioxide, food coloring, food color lake, clean the teeth one or more of particle.
The present invention provides a kind of preferred embodiment, the toothpaste, based on 100 parts, including following component：
Third object of the present invention is, provides a kind of mouthwash, and the mouthwash includes any of the above-described group
Close object；
Preferably, the mouthwash further includes solvent and function additive, and the function additive is selected from moisturizer, surface-active
Two kinds in agent, thickener, ethyl alcohol, food flavor and colorant and a variety of；
It is highly preferred that the function additive is made of following component：
The moisturizer is selected from one or more of sorb (sugar) alcohol, propylene glycol, glycerine, polyethylene glycol-8；
The surfactant is selected from poloxamer188, lauryl sodium sulfate, sodium lauroyl sarcosine, cocounut oil acyl first
One or more of base sodium taurocholate；
The thickener is selected from one or more of cellulose, card ripple, carragheen；
The food flavor is selected from cloves, Chinese cassia tree perfume, fragrance of osmanthus, peppermint oil, vanilla, spearmint, minty note, Chinese ilex
One or more of peppermint；
The colorant is selected from one or more of green, blueness, red.
The present invention provides a kind of preferred embodiment, the mouthwash, based on 100 parts, including following component：
Using the different medical mechanism of each ingredient, the collaboration given full play between each ingredient increases composition provided by the present invention
Effect acts on so that the composition of gained can mitigate gingivitis, accelerate canker sore healing, remove intraoral helicobacter pylorus
Bacterium.
Specific embodiment
The present invention is explained further below by way of specific embodiment, it is noted that for the common of the art
For technical staff, various improvements and modifications may be made without departing from the principle of the present invention, these are improved and profit
Decorations also should be regarded as protection scope of the present invention.
Examples 1 to 6
Examples 1 to 6 provides a kind of composition, by weight, is made of following component：
Table 1
Embodiment 7~9
Embodiment 7~9 provides a kind of composition, by weight, is made of following component：
Table 2
Embodiment 10~14
Embodiment 10~14 provides a kind of composition, by weight, is made of following component：
Table 3
Embodiment 15~20
In order to illustrate advantages of the present invention, toothpaste is made with conventional method in Examples 1 to 6 by the present invention, based on 100 parts,
It is made of following component：
Table 4
Embodiment 21~23
In order to illustrate advantages of the present invention, toothpaste is made with conventional method in embodiment 7~9 by the present invention, based on 100 parts,
It is made of following component：
Table 5
Preparation method：Above-mentioned raw materials are conventionally uniformly mixed obtained toothpaste.
Embodiment 24~28
In order to illustrate advantages of the present invention, toothpaste is made with conventional method in embodiment 9~13 by the present invention, based on 100 parts,
It is made of following component：
Table 6
Preparation method：Above-mentioned raw materials are conventionally uniformly mixed obtained toothpaste.
Embodiment 29~31
Embodiment 29~31 provides a kind of mouthrinse composition, based on 100 parts, is made of following component：
Table 7
Preparation method：Above-mentioned raw materials are conventionally uniformly mixed obtained mouthwash.
Embodiment 32~34
Embodiment 32~34 provides a kind of mouthrinse composition, based on 100 parts, is made of following component：
Table 8
Preparation method：Above-mentioned raw materials are conventionally uniformly mixed obtained mouthwash.
Embodiment 35~39
Embodiment 33~39 provides a kind of mouthrinse composition, based on 100 parts, is made of following component：
Table 9
Preparation method：Above-mentioned raw materials are conventionally uniformly mixed obtained mouthwash.
Comparative example 1-3
Comparative example 1~3 provides a kind of composition, other raw materials and proportion are constant, by the use of Cetylpyridinium Chloride (as surface-active
Agent inhibits by reducing surface tension and kills bacterium；Periodontal disease is treated, controls bacterial plaque, oral cavity is removed and reads coccus, kill
The smelly bacterium of cause in mouthful source property halitosis patient oral cavity can inhibit oral helicobacter pylori in the case that oral conditions are preferable for a long time
Growth.) sodium azulenesulfonate in alternative embodiment 1~3, by weight, it is made of following component：
Table 10
Comparative example 4~6
Comparative example 4~6 provides a kind of composition, by weight, is made of following component：
Table 11
Comparative example 7~10
Comparative example 7~10 provides a kind of composition, by weight, is made of following component：
Table 12
Comparative example 11~13
Comparative example 11~13 provides a kind of dentifrice composition, by weight, is made of following component：
Table 13
Comparative example 14~16
Comparative example 14~16 provides a kind of dentifrice composition, by weight, is made of following component：
Table 14
Comparative example 17~20
Comparative example 17~20 provides a kind of dentifrice composition, by weight, is made of following component：
Table 15
Test example 1
Embodiment 15~20 and comparative example 11~13 are compared.
1st, human trial (to the therapeutic effect of gingivitis)
Volunteer of the selection with gum swelling, bleeding participates in the normal individual trial experiment of toothpaste, according to test specimen
Number is grouped at random, every group of 25 people, and each group using the toothpaste in embodiment and comparative example, respectively uses one sooner or later daily respectively
It is secondary, after four weeks, carry out gingivitis treatment effect research.
Curative effect determinate standard is as follows：
It cures：Patient's subjective symptoms disappears and gingivitis thoroughly disappears, and is damaged the visible newborn collagen of gingival connective tissue
Fiber, gum function, color, shape, matter recover normal；
It improves：Patient's gum and gum nipple are micro- red, there is slight oedema, hyperemia, and matter is crisp, and gum is being touched with blunt nosed round probe
There is a little petechial hemorrhage during ditch；
It is invalid：Patient's gum still swells and ache, and symptom and sign have no improvement, and visible bleeding is examined in spy.
Treat total effective rate=(healing+improvement)/total number of cases × 100%.
As a result such as following table：
Table 16
2nd, human trial (to the therapeutic effect of canker sore)
Selection has canker sore medical history 1 year or more；Recurrent exerbation, every month at least break out once；In stage of attack, and send out
Make the time 48 it is small when it is interior；Experiment of the toothpaste to dental ulcer treatment effect is participated in the patient of halitosis simultaneously, according to test sample
Product number is grouped at random, every group of 25 people, and each group using the toothpaste in embodiment and comparative example, respectively uses one sooner or later daily respectively
It is secondary, oral helicobacter pylori clearance rate, halitosis phenomenon disappearance rate and dental ulcer treatment effect are detected after 8 weeks.
Dental ulcer treatment Indexes of Evaluation Effect：
Total intermittent time (my god) (interval, I)：The period is evaluated without ulcer temporal summation.
Total ulcer number (a) (number, N)：Evaluate period ulcer recurrence number summation.
Evaluation index is classified：
I1- total intermittent times extend (t inspections, P<0.05)
I0- total intermittent times, (t was examined, P without changing>0.05)
N1-total ulcer number reduces (t inspections, P<0.05)
Without changing, (t is examined N1-total ulcer number, P>0.05)
Evaluation criterion：
Recovery from illness：Canker sore terminates recurrence 1 year or more
It is effective：I1N1
Effectively：I0N1 or I1N0
It is invalid：I0N0
Efficient=(cure+effective+effectively)/total number of cases × 100%.
As a result such as following table：
Table 17
The above results are understood, in the case where effective ingredient consumption is identical, by sodium azulenesulfonate, Baical Skullcap root P.E, dandelion
Extract is used in combination, and acquired significant effect is better than being combined with Cetylpyridinium Chloride, Baical Skullcap root P.E, dandelion extract
The effect used.
Test example 2
In a manner that test example 1 is identical, embodiment 21~23 and comparative example 14~16 are compared.
1st, human trial (to the therapeutic effect of gingivitis) is as a result as follows：
Table 18
2nd, human trial (to the therapeutic effect of canker sore) is as a result as follows：
Table 19
The above results understand that one or more of addition honeysuckle, peppermint, rheum officinale, betel nut, Radix Glycyrrhizae can further carry
The effect of high composition.
Test example 3
In a manner that test example 1 is identical, embodiment 24~28 and comparative example 17~20 are compared.
1st, human trial (to the therapeutic effect of gingivitis) is as a result as follows：
Table 20
2nd, human trial (to the therapeutic effect of canker sore) is as a result as follows：
Table 21
The above results understand, addition Herba portulacae, Radix Astragali, myrrh, purple daisy, Salvia japonica, Radix Angelicae Sinensis, Chinese herbaceous peony, cover disk at Cortex Phellodendri
Son, Jing Hua, Fructus Forsythiae, curcuma zedoary, rhizoma cyperi, Rhizoma Atractylodis Macrocephalae, evodia rutaecarpa, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Notoginseng powder can further improve the effect of composition
Fruit.
Although above having used general explanation, specific embodiment and experiment, the present invention is made to retouch in detail
It states, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (10)
1. a kind of composition, which is characterized in that by weight, including following component：
0.0001~2 part of sodium azulenesulfonate；
0.1~15 part of Baical Skullcap root P.E；
0.1~25 part of dandelion extract；
Preferably, the composition, by weight, including following components：
0.05~1 part of sodium azulenesulfonate；
2~9 parts of Baical Skullcap root P.E；
1~12 part of dandelion extract.
2. composition according to claim 1, which is characterized in that scutelloside, wogonoside in the Baical Skullcap root P.E,
Baicalein, the total amount of wogonin are not less than 85%；And/or the dandelion extract include taraxasterol, choline,
Synanthrin, pectin；Taraxol, stigmasterol, β-amyrin, cupreol, taraxerol, taraxacin, taraxacin,
Vitamin A, vitamin B and vitamin C.
3. composition according to claim 1 or 2, which is characterized in that the composition further includes honeysuckle, peppermint, big
Huang, betel nut, Radix Glycyrrhizae, Herba portulacae, Radix Astragali, Cortex Phellodendri, myrrh, purple daisy, Salvia japonica, Radix Angelicae Sinensis, Chinese herbaceous peony, cover plate, Jing Hua, Fructus Forsythiae,
One or more in curcuma zedoary, rhizoma cyperi, Rhizoma Atractylodis Macrocephalae, evodia rutaecarpa, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Notoginseng powder.
4. composition according to claim 3, which is characterized in that by weight, in the composition, further include as follows
Component：
0.1~24 part of honeysuckle；
Or, it also comprises the following components：
Or, it also comprises the following components：
5. composition according to claim 1, which is characterized in that by weight, including following component：
Preferably, the composition, by weight, including following component：
6. composition according to claim 1, which is characterized in that by weight, including following component：
7. a kind of toothpaste, which is characterized in that including any composition of claim 1~6；
Preferably, the toothpaste further includes solvent and function additive, the function additive be selected from rubbing agent, moisturizer, foaming agent,
Two or more in thickener, sweetener, essence, preservative, appearance modifying agents；
It is highly preferred that the function additive is made of following component：
8. toothpaste according to claim 7, which is characterized in that based on 100 parts, including following component：
9. a kind of mouthwash, which is characterized in that including any composition of claim 1~6；
Preferably, the mouthwash further includes solvent and function additive, the function additive be selected from moisturizer, surfactant,
Two kinds in thickener, ethyl alcohol, food flavor and colorant and a variety of；
It is highly preferred that the function additive is made of following component：
10. mouthwash according to claim 9, which is characterized in that based on 100 parts, including following component：
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110507813A (en) * | 2019-10-12 | 2019-11-29 | 德州学院 | Cure mainly the traditional Chinese medicine reagent and its preparation method of canker sore |
| CN112022775A (en) * | 2020-10-13 | 2020-12-04 | 福州比格艾普科技有限公司 | Oral care product for resisting helicobacter pylori |
| CN112716854A (en) * | 2021-01-27 | 2021-04-30 | 新乡博凯生物技术有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN113230165A (en) * | 2021-04-02 | 2021-08-10 | 北京圣永制药有限公司 | A collutory containing marrubium vulgare extract with antiinflammatory and antibacterial effects |
| CN114652669A (en) * | 2022-04-22 | 2022-06-24 | 江苏雪豹日化有限公司 | Toothpaste with effects of clearing away fire and resisting allergy and preparation method thereof |
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