CN105535582A - A medicine composition for treating gingivitis - Google Patents

Abstract

A medicine composition for treating gingivitis is provided. Raw material medicines of the medicine comprise fourleaf ladybell root, dyers woad leaves, amur cork-tree, sargentgloryvine stem, largeleaf Japanese ginseng rhizome, sappan wood, hempleaf negundo chastetree leaves, lightyellow sophora root, Chinese gall, figwort root, christina loosestrife, eleusine indica, indigofera tinctoria, myrrh, Chinese taxillus herb, franzenbach rhubarb root and rhizome, aleppo avens, honeysuckle stem, rabdosia amethystoides, whiteligulate aster and mysorethorn root. The medicine has anti-inflammatory and antibacterial functions, is capable of regulating oral cavity microecological balance and promoting regeneration and recovery of gingival tissues, and is convenient to use and free of side and toxic effects and drug resistance.

Description

Be used for the treatment of the medicine of gingivitis

Technical field

The present invention relates to technical field of Chinese medicine, particularly relate to a kind of collutory being used for the treatment of gingivitis.

Background technology

Gingivitis is one of prevailing disease of the mankind, each department all over the world, each race, each age level, and its prevalence is up to more than 90%, and gingivitis has become outstanding oral cavity health problem.Its cause of disease is if treated not in time, can develop into periodontitis under certain condition by a series of immunization inflammatory reaction that the bacterial biof iotalm of gingiva and periodontal tissue is brought out, and causes the Progressive symmetric erythrokeratodermia of tooth essence to destroy, finally causes odontoseisis, come off.The generation of gingivitis, mainly because oral cavity bacterium bacterial plaque stimulates gingiva, causes gingiva congestion and edema.Current main method be application broad ectrum antibiotic, but due to gingivitis be a kind of chronic progressive disease.If widely apply antibiotic for a long time, a series of complication can be caused, and use inconvenient, easily cause multiple side effect, produce drug resistance.

Gingivitis is infectious disease, and main infection source is the microorganism of dental plaque in neck portion and gingival sulcus.Bacterial plaque microorganism and product long term thereof, in gingiva, cause the immune response of body, first cause the inflammatory reaction of gingiva.When suffering from gingivitis, pathological changes is confined in gingival epithelium and connective tissue.Be extended down to deep periodontal tissue when inflammation expands, the change such as frontal resorption and pericemental dissolving, destruction can be caused.So effectively control dental plaque, control gingivitis, blocks the generation of periodontal disease.In addition, the key for the treatment of gingivitis diminishes inflammation, and maintains Oral health behaviours balance, keep the health of gingiva tissue.

Gingivitis belongs to the categories such as traditional Chinese medical science toothache, gingival abscess, bleeding from the gum.Research in recent years shows, the treatment of Chinese medicine has certain curative effect, and uses external treatment treatment gingivitis to be paid attention to gradually, also achieves certain effect.

According to motherland's theory of medicine, think that its morbidity is flourishing based on pathogenic fire, for the bright stomach of sun through excess-fire or few cloudy kidney channel deficiency of YIN fire high, hyperactivity of deficient fire or both have concurrently.The internal organs such as morbidity and gastrointestinal, liver and gall, kidney have close relationship, and its taste are had one's ideas straightened out in mouth, and brothers' Yangming Channel arteries and veins follows row in upper and lower gingiva; When taste, dampness-heat in the liver and gallbladder are accumulate poly-, Chang Xunjing disturbs, cause red swelling of gingiva pain, or pyorrhea, when diseases such as bleeding due to blood-heat can cause gingival hemorrhage, bitter taste halitosis, therefore, in treatment, follow the principle of clearing away heat-fire (excess-fire), nourishing YIN to lower pathogenic fire (asthenic fire), parasite killing pain relieving, detoxicating, relieving inflammation.

The invention provides a kind of medicine being used for the treatment of gingivitis, its existing antiinflammatory and bacteriostatic functions, Oral health behaviours can be regulated to balance, have again and promote gingiva tissue regeneration, repair, easy to use, not there is toxic and side effects and drug resistance.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of gingivitis, its existing antiinflammatory and bacteriostatic functions, Oral health behaviours can be regulated to balance, have again and promote gingiva tissue regeneration, repair, easy to use, not there is toxic and side effects and drug resistance.

For solving the problems of the technologies described above, the invention provides a kind of medicine being used for the treatment of gingivitis, its crude drug comprises Radix Adenophorae, Folium Isatidis, Cortex Phellodendri, Caulis Sargentodoxae, Rhizoma Panacis Majoris, Lignum Sappan, Folium Viticis Negundo, Radix Sophorae Flavescentis, Galla Chinensis, Radix Scrophulariae, Herba Lysimachiae, Herba Eleusines Indicae, Folium et Caulis Indigoferae Tinctoriae, Myrrha, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici, Caulis Lonicerae, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis and Radix Caesalpiniae Radicis.

Wherein, in described medicine, the weight of each crude drug is respectively Radix Adenophorae 35g ~ 45g, Folium Isatidis 50g ~ 60g, Cortex Phellodendri 30g ~ 40g, Caulis Sargentodoxae 20g ~ 30g, Rhizoma Panacis Majoris 40g ~ 50g, Lignum Sappan 20g ~ 30g, Folium Viticis Negundo 30g ~ 40g, Radix Sophorae Flavescentis 35g ~ 45g, Galla Chinensis 35g ~ 45g, Radix Scrophulariae 25g ~ 35g, Herba Lysimachiae 20g ~ 30g, Herba Eleusines Indicae 25g ~ 35g, Folium et Caulis Indigoferae Tinctoriae 20g ~ 30g, Myrrha 35g ~ 45g, Herba Taxilli 30g ~ 40g, Radix et Rhizoma Rhei Franzenbachii 30g ~ 40g, Radix seu Herba Gei aleppici 30g ~ 40g, Caulis Lonicerae 25g ~ 35g, Herba Rabdosiae glaucocalycis 20g ~ 30g, Herba Asteris Ageratoidis 35g ~ 45g and Radix Caesalpiniae Radicis 20g ~ 30g.

Wherein, in described medicine, the weight of each crude drug is respectively Radix Adenophorae 40g ~ 45g, Folium Isatidis 55g ~ 60g, Cortex Phellodendri 35g ~ 40g, Caulis Sargentodoxae 25g ~ 30g, Rhizoma Panacis Majoris 45g ~ 50g, Lignum Sappan 25g ~ 30g, Folium Viticis Negundo 35g ~ 40g, Radix Sophorae Flavescentis 40g ~ 45g, Galla Chinensis 40g ~ 45g, Radix Scrophulariae 30g ~ 35g, Herba Lysimachiae 20g ~ 25g, Herba Eleusines Indicae 25g ~ 30g, Folium et Caulis Indigoferae Tinctoriae 20g ~ 25g, Myrrha 35g ~ 40g, Herba Taxilli 30g ~ 35g, Radix et Rhizoma Rhei Franzenbachii 30g ~ 35g, Radix seu Herba Gei aleppici 30g ~ 35g, Caulis Lonicerae 25g ~ 30g, Herba Rabdosiae glaucocalycis 20g ~ 25g, Herba Asteris Ageratoidis 35g ~ 40g and Radix Caesalpiniae Radicis 20g ~ 25g.

Wherein, in described medicine, the weight of each crude drug is respectively Radix Adenophorae 40g, Folium Isatidis 55g, Cortex Phellodendri 35g, Caulis Sargentodoxae 25g, Rhizoma Panacis Majoris 45g, Lignum Sappan 25g, Folium Viticis Negundo 35g, Radix Sophorae Flavescentis 40g, Galla Chinensis 40g, Radix Scrophulariae 30g, Herba Lysimachiae 25g, Herba Eleusines Indicae 30g, Folium et Caulis Indigoferae Tinctoriae 25g, Myrrha 40g, Herba Taxilli 35g, Radix et Rhizoma Rhei Franzenbachii 35g, Radix seu Herba Gei aleppici 35g, Caulis Lonicerae 30g, Herba Rabdosiae glaucocalycis 25g, Herba Asteris Ageratoidis 40g and Radix Caesalpiniae Radicis 25g.

Wherein, described medicine is external used medicine.

Wherein, described is dentifrice or collutory.

The present invention also provides the preparation method of said medicine, and when the dosage form of described medicine is dentifrice, it is specially:

The first step, gets Radix Adenophorae, Folium Isatidis, Cortex Phellodendri, Rhizoma Panacis Majoris, Radix Sophorae Flavescentis, Galla Chinensis, Radix Scrophulariae, Myrrha, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici, mixes by described weight, be ground into 100 object powder, be 25 ~ 45MPa at pressure, temperature is under 40 ~ 50 DEG C of conditions, adopts supercritical CO ₂extract 1.5 ~ 2.5 hours, collect extract, extract adds determining alcohol 70 ~ 80% ethanol, is heated to 50 ~ 70 DEG C, constantly stirs, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, and separates out precipitation, filter, concentrating under reduced pressure, dry, pulverize into 200 object powder;

Second step, by remaining components by described weight mixing, obtains mixture, is ground into 100 object powder, be placed in the container of sealing, add the water relative to 2 ~ 4 times, mixture, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, pulverize into 200 object powder;

3rd step, the powder first step and second step prepared mixes, and obtains medicated powder, gets medicated powder prepared by 150g, 2kg300 object calcium hydrogen phosphate, the sodium lauryl sulphate of 100g, 50g Oleum menthae, 5g sodium benzoate and 5g Margarita powder and mixes, obtain dentifrice.

The present invention also provides the preparation method of said medicine, and when the dosage form of described medicine is collutory, it is specially:

The first step, gets Radix Adenophorae, Folium Isatidis, Cortex Phellodendri, Rhizoma Panacis Majoris, Radix Sophorae Flavescentis, Galla Chinensis, Radix Scrophulariae, Myrrha, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici, mixes by described weight, be ground into 100 object powder, be 25 ~ 45MPa at pressure, temperature is under 40 ~ 50 DEG C of conditions, adopts supercritical CO ₂extract 1.5 ~ 2.5 hours, collect extract, extract adds determining alcohol 70 ~ 80% ethanol, is heated to 50 ~ 70 DEG C, constantly stirs, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, and separates out precipitation, filter, concentrating under reduced pressure, dry, pulverize into 200 object powder;

Second step, by remaining components by described weight mixing, obtains mixture, is ground into 100 object powder, be placed in the container of sealing, add the water relative to 2 ~ 4 times, mixture, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, pulverize into 200 object powder;

3rd step, the powder first step and second step prepared mixes, and obtains medicated powder, gets 100g medicated powder, 30g glucide, benzoic acid 3g, glycyrrhizic acid 3g, Oleum menthae 2g, 30g sodium lauryl sulphate and 1L water mix homogeneously, obtains collutory.

Beneficial effect of the present invention:

Provided by the invention be used for the treatment of gingivitis the existing antiinflammatory and bacteriostatic functions of medicine, Oral health behaviours can be regulated to balance, have again and promote gingiva tissue regeneration, repair, easy to use, not there is toxic and side effects and drug resistance.

Detailed description of the invention

The invention provides a kind of medicine being used for the treatment of gingivitis, its crude drug comprises Radix Adenophorae, Folium Isatidis, Cortex Phellodendri, Caulis Sargentodoxae, Rhizoma Panacis Majoris, Lignum Sappan, Folium Viticis Negundo, Radix Sophorae Flavescentis, Galla Chinensis, Radix Scrophulariae, Herba Lysimachiae, Herba Eleusines Indicae, Folium et Caulis Indigoferae Tinctoriae, Myrrha, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici, Caulis Lonicerae, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis and Radix Caesalpiniae Radicis.

Further preferably, described medicine is only made up of above-mentioned raw materials medicine.

Fang Zhong, Radix Adenophorae yin nourishing pathogenic fire reducing, Folium Isatidis heat-clearing and toxic substances removing, and the effect having light a surname evacuation, Rhizoma Panacis Majoris reducing swelling and alleviating pain, hemostasis, antibacterial, and can enhancing human body immunity power, improve local blood circulation, reduce inflammatory exudation, promote epithelial repair, Semen Myristicae acrid in the mouth wets, and function is warming middle-JIAO to send down the adverse QI, warming the kidney to activate YANG, Cortex Phellodendri has heat clearing away, dampness, the merit of pathogenic fire purging, especially to gastrointestinal, caused by dampness-heat in the liver and gallbladder, disease is excellent, and Caulis Sargentodoxae relieves internal heat eliminating carbuncle, wind dispelling insecticide, and Lignum Sappan dissipating blood stasis stops blooding, reducing swelling and alleviating pain, Folium Viticis Negundo removing toxic substances dehumidifying, parasite killing pain relieving, Radix Sophorae Flavescentis heat clearing and damp drying, wind dispelling insecticide, Galla Chinensis is astringed the lung pathogenic fire reducing, removing toxic substances sore, Radix Scrophulariae clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, Herba Lysimachiae clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, Herba Eleusines Indicae heat-clearing and toxic substances removing, cool the blood dissipate blood stasis, Folium et Caulis Indigoferae Tinctoriae heat-clearing and toxic substances removing, cooling blood for hemostasis, Myrrha promoting blood circulation and stopping pain, detumescence and promoting granulation, Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, Radix et Rhizoma Rhei Franzenbachii purges heat removing toxic substances, removing heat from blood clots absorbing, Radix seu Herba Gei aleppici analgesia blood pressure lowering, and regulating menstruation dehumidifies, Caulis Lonicerae heat-clearing and toxic substances removing, dispelling wind dredging collateral, Herba Rabdosiae glaucocalycis clearing away heat-damp and promoting diuresis, promoting blood circulation and detoxication, Herba Asteris Ageratoidis thermal detoxification, eliminate the phlegm removing heat from blood, Radix Caesalpiniae Radicis removing toxic substances and promoting subsidence of swelling, and all medicines share, and plays clearing away heat-fire (excess-fire) altogether, nourishing YIN to lower pathogenic fire (asthenic fire), parasite killing pain relieving, effect of detoxicating, relieving inflammation.

Radix Adenophorae: sweet in the mouth, micro-hardship, cold nature, enter lung, stomach warp, there is nourishing the lung to arrest cough, the effect of nourishing the stomach to promote the production of body fluid, be mainly used in lung-dryness syndrome due to deficiency of YIN, dry cough few expectorant, chronic cough expectorant blood, the cards such as the few tongue of deficiency of stomach-Yin, mouthfeel parched throat, constipation, red tongue, cellular immunization and non-specific immunity can be improved, suppress humoral immunization, there is the function of immunity moderation balance.

Folium Isatidis: latin name IsatidisFolium, bitter in the mouth, property Great Cold, GUIXIN, liver, gallbladder, stomach warp, have antipyretic and detoxicated, cooling blood and dissolving purpura, effect of jaundice eliminating, can the excess-heat that divides of clearing heat in QI system, can separate again the pyretic toxicity of blood system, the high febrile perspiration being mainly used in pestilence calentura caused goes out, excessive thirst taking fluids profusely; The speckle that fire-toxin is flourishing is gone mad, the symptoms such as haematemesis; The unconsciousness due to high fever of measles, rash color is purple dark; Dampness-heat in the liver and gallbladder accumulates the jaundice of steaming; The deafness and tinnitus of liver and gall fire liter; The card such as pharyngalgia, aphtha of the mouth and tongue, hepatitis that fire stagnation pyretic toxicity is caused.

Cortex Phellodendri: latin name PhellodendriChinensisCortex, bitter in the mouth, cold in nature, enter kidney, bladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, and seminal emission, sore swollen toxin, the cards such as eczema pruritus, Cortex Phellodendri has good antibacterial action to multiple gram-positive bacterium.

Caulis Sargentodoxae: bitter in the mouth, property is put down, and returns liver, large intestine channel, has the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cure mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.

Rhizoma Panacis Majoris: bitter in the mouth, sweet, cold nature, enters liver, lung, stomach warp, have tonifying the lung yin nourishing, dissipating blood stasis stops blooding, the effect of reducing swelling and alleviating pain,, cough due to consumptive disease thirsty for deficiency of both QI and YIN, excessive thirst, various hemorrhage, as haematemesis, hemoptysis, have blood in stool, hematuria, metrorrhagia, traumatic injury wound is swollen, rheumatic arthritis, stomachache, acute toothache, laryngopharynx swelling and pain, the cards such as sore and toxic.

Lignum Sappan: latin name sappanlignum, sweet in the mouth, salty, property is put down, and enters the heart, liver, large intestine channel, has blood circulation promoting and blood stasis dispelling, the effect of reducing swelling and alleviating pain, for blood stasis amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, traumatic injury, the cards such as fracture carbuncle sore tumefacting virus.

Folium Viticis Negundo: latin name ViticisNegundoFolium, acrid in the mouth; Bitter; Property is put down, and returns lung meridian, has removing dampness of inducing sweat, eliminating phlegm and relieving asthma; Removing toxic substances, expelling pathogenic wind from the body surface, dehumidifying, parasite killing, effect of pain relieving, cures mainly Common Cold, cough, asthma; Stomachache; Stomachache; Heat-damp in summer dysentery; Beriberi swelling; Rubella pruritus; Tinea pedis; Acute mastitis swells and ache; The cards such as snake bite and insect sting.

Radix Sophorae Flavescentis: latin name SophoraeFlavescentisRadix, bitter in the mouth, cold in nature, enter the heart, stomach, large intestine, urinary bladder channel, there is the effect of heat clearing and damp drying, wind dispelling insecticide, be mainly used in damp-heat dysentery, jaundice, stranguria, Radix Sophorae Flavescentis has obvious inhibitory action to dysentery bacterium, escherichia coli, Bacillus proteus, group B streptococcus and staphylococcus aureus.

Galla Chinensis: latin name GallaChinensis, sour in the mouth, puckery, cold in nature, enter lung, large intestine, kidney channel, have the effect of convergence astringing intestine to stop diarrhea, pathogenic fire reducing of astringing the lung, removing toxic substances sore, be mainly used in incessant chronic diarrhea, proctoptosis is not received; Metrostaxis, hematuria of having blood in stool; The symptoms such as the seminal emission enuresis, have significant inhibitory action to staphylococcus aureus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus.

Semen Myristicae: latin name myristicaesemen, acrid in the mouth, hardship, warm in nature, enter spleen, stomach, large intestine channel, there is the effect of warming middle-JIAO astringing intestine to stop diarrhea, promote qi circulation digestion promoting, the card such as not disappear for diarrhea of deficiency type, cold-dysentery, abdominal distention, lack of appetite vomiting, dyspepsia.

Radix Scrophulariae: bitter in the mouth, sweet, salty, cold nature, enters lung, stomach, kidney channel, has the effect of clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens, for warm febrile disease join the army blood, intense heat in both QI and blood systems, send out speckle dermexanthesis; Consumption of YIN caused by febrile disease, Tianjin hinder constipation, hectic fever due to YIN-deficiency chronic cough; Conjunctival congestion is red and swollen, have sore throat, and the treatment of the card such as too fat to move sore, Radix Scrophulariae has obvious inhibitory action to staphylococcus aureus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, group B streptococcus, escherichia coli, shigella flexneri.

Herba Lysimachiae: sweet in the mouth, slightly stringy pulse, cold nature, enters liver, gallbladder, kidney, urinary bladder channel, has effect of clearing away heat-damp and promoting diuresis, Tonglin Paishi, removing toxic substances and promoting subsidence of swelling, cures mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; The cards such as traumatic injury.

Herba Eleusines Indicae: be root or the herb of grass family yard grass platymiscium Herba Eleusines Indicae, sweet in the mouth, light, cool in nature, there is heat-clearing and toxic substances removing, dampness removing, effect of cool the blood dissipate blood stasis, cure mainly Sunstroke heating, infantile convulsion, encephalitis b, epidemic encephalitis, jaundice, stranguria; dysuria, dysentery, has blood in stool, urticaria, the cards such as traumatic injury.

Folium et Caulis Indigoferae Tinctoriae: be the stem and leaf of pulse family anil Folium et Caulis Indigoferae Tinctoriae, mildly bitter flavor, cold in nature, have heat-clearing and toxic substances removing, effect of cooling blood for hemostasis, cures mainly encephalitis B, parotitis, acute pharyngolaryngitis, lymphadenitis, conjunctival congestion, aphtha, erysipelas, scabies, worm venom, the cards such as haematemesis.

Myrrha: bitter in the mouth, pungent, property is put down, and enters liver, spleen, the heart, kidney channel, has effect of promoting blood circulation and stopping pain, detumescence and promoting granulation, cure mainly the cards such as breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.

Herba Taxilli: bitter in the mouth, sweet, property is put down, and enters liver, kidney channel, have the effect of invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit, for the soreness of waist pain caused by deficiency of the liver and kindey, muscles and bones flaccidity is soft, the foot and knee being feeble, deficiency of the liver and kindey, essence and blood void is lost, the frequent fetal movement of liability to abortion, the cards such as waist abdomen pain.

Radix et Rhizoma Rhei Franzenbachii: latin name RadixetRhizomeRheiFranzenbachii is the root and rhizome of polygonaceae plant rheum rhabarbarum, bitter in the mouth; Cold in nature, return stomach; Large intestine channel, has removing toxic substances of purging heat; Effect of removing heat from blood clots absorbing, cures mainly jaundice due to damp-heat; Dysentery; Amenorrhea is suffered from abdominal pain; Hematemesis and epistaxis; Traumatic injury stasis of blood pain; Carbuncle furunculosis; Aphthous stomatitis; The cards such as burn and scald.

Radix seu Herba Gei aleppici: latin name GeiHerba, acrid in the mouth, hardship, property is put down, and return liver, spleen, lung meridian, have analgesia, blood pressure lowering, regulating menstruation, effect of expelling wind and removing dampness, cures mainly hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, infantile convulsion, lumbago, skelalgia of rheumatism; Carbuncle furuncle and phyma poison is controlled in external, the cards such as traumatic injury.

Caulis Lonicerae: sweet in the mouth, cold in nature, attach to the lung and stomach meridians, there is heat-clearing and toxic substances removing, effect of dispelling wind dredging collateral, cure mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, the cards such as redness and swelling of joints burning pain.

Herba Rabdosiae glaucocalycis: bitter in the mouth, pungent, gas is fragrant, and cool in nature, GUIXIN, liver, spleen channel, have clearing away heat-damp and promoting diuresis, and effect of promoting blood circulation and detoxication, cures mainly jaundice due to damp-heat, stranguria, edema, laryngopharynx swelling and pain, arthralgia, amenorrhea, acute mastitis, hemorrhoid, traumatic injury, the cards such as venom.

Herba Asteris Ageratoidis: bitter in the mouth, pungent, cool in nature, have heat-clearing and toxic substances removing, the effect of the removing heat from blood that eliminates the phlegm, cures mainly cold, fever, tonsillitis, bronchitis, hepatitis, enteritis, pyretic stranguria, carbuncle furunculosis, the cards such as snake bite and insect sting.

Radix Caesalpiniae Radicis: bitter in the mouth, pungent, property is put down, and have expelling wind and removing dampness, effect of removing toxic substances and promoting subsidence of swelling, cures mainly cold, fever, cough, laryngopharynx swelling and pain, toothache, rheumatic arthralgia, hepatitis, dysentery, stranguria, skin pruritus, the cards such as venom.

In described medicine, the weight of each crude drug is respectively Radix Adenophorae 35g ~ 45g, Folium Isatidis 50g ~ 60g, Cortex Phellodendri 30g ~ 40g, Caulis Sargentodoxae 20g ~ 30g, Rhizoma Panacis Majoris 40g ~ 50g, Lignum Sappan 20g ~ 30g, Folium Viticis Negundo 30g ~ 40g, Radix Sophorae Flavescentis 35g ~ 45g, Galla Chinensis 35g ~ 45g, Radix Scrophulariae 25g ~ 35g, Herba Lysimachiae 20g ~ 30g, Herba Eleusines Indicae 25g ~ 35g, Folium et Caulis Indigoferae Tinctoriae 20g ~ 30g, Myrrha 35g ~ 45g, Herba Taxilli 30g ~ 40g, Radix et Rhizoma Rhei Franzenbachii 30g ~ 40g, Radix seu Herba Gei aleppici 30g ~ 40g, Caulis Lonicerae 25g ~ 35g, Herba Rabdosiae glaucocalycis 20g ~ 30g, Herba Asteris Ageratoidis 35g ~ 45g and Radix Caesalpiniae Radicis 20g ~ 30g.

Further preferably, in described medicine, the weight of each crude drug is respectively Radix Adenophorae 40g ~ 45g, Folium Isatidis 55g ~ 60g, Cortex Phellodendri 35g ~ 40g, Caulis Sargentodoxae 25g ~ 30g, Rhizoma Panacis Majoris 45g ~ 50g, Lignum Sappan 25g ~ 30g, Folium Viticis Negundo 35g ~ 40g, Radix Sophorae Flavescentis 40g ~ 45g, Galla Chinensis 40g ~ 45g, Radix Scrophulariae 30g ~ 35g, Herba Lysimachiae 20g ~ 25g, Herba Eleusines Indicae 25g ~ 30g, Folium et Caulis Indigoferae Tinctoriae 20g ~ 25g, Myrrha 35g ~ 40g, Herba Taxilli 30g ~ 35g, Radix et Rhizoma Rhei Franzenbachii 30g ~ 35g, Radix seu Herba Gei aleppici 30g ~ 35g, Caulis Lonicerae 25g ~ 30g, Herba Rabdosiae glaucocalycis 20g ~ 25g, Herba Asteris Ageratoidis 35g ~ 40g and Radix Caesalpiniae Radicis 20g ~ 25g.

Most preferably, in described medicine, the weight of each crude drug is respectively Radix Adenophorae 40g, Folium Isatidis 55g, Cortex Phellodendri 35g, Caulis Sargentodoxae 25g, Rhizoma Panacis Majoris 45g, Lignum Sappan 25g, Folium Viticis Negundo 35g, Radix Sophorae Flavescentis 40g, Galla Chinensis 40g, Radix Scrophulariae 30g, Herba Lysimachiae 25g, Herba Eleusines Indicae 30g, Folium et Caulis Indigoferae Tinctoriae 25g, Myrrha 40g, Herba Taxilli 35g, Radix et Rhizoma Rhei Franzenbachii 35g, Radix seu Herba Gei aleppici 35g, Caulis Lonicerae 30g, Herba Rabdosiae glaucocalycis 25g, Herba Asteris Ageratoidis 40g and Radix Caesalpiniae Radicis 25g.

Medicine provided by the invention is external used medicine, can be dentifrice or collutory.

The present invention also provides the preparation method of said medicine, and when the dosage form of described medicine is dentifrice, it is specially:

The first step, gets Radix Adenophorae, Folium Isatidis, Cortex Phellodendri, Rhizoma Panacis Majoris, Radix Sophorae Flavescentis, Galla Chinensis, Radix Scrophulariae, Myrrha, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici, mixes by described weight, be ground into 100 object powder, be 25 ~ 45MPa at pressure, temperature is under 40 ~ 50 DEG C of conditions, adopts supercritical CO ₂extract 1.5 ~ 2.5 hours, collect extract, extract adds determining alcohol 70 ~ 80% ethanol, is heated to 50 ~ 70 DEG C, constantly stirs, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, and separates out precipitation, filter, concentrating under reduced pressure, dry, pulverize into 200 object powder;

Second step, by remaining components by described weight mixing, obtains mixture, is ground into 100 object powder, be placed in the container of sealing, add the water relative to 2 ~ 4 times, mixture, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, pulverize into 200 object powder;

3rd step, the powder first step and second step prepared mixes, and obtains medicated powder, gets medicated powder prepared by 150g, 2kg300 object calcium hydrogen phosphate, the sodium lauryl sulphate of 100g, 50g Oleum menthae, 5g sodium benzoate and 5g Margarita powder and mixes, obtain dentifrice.

The present invention also provides the preparation method of said medicine, and when the dosage form of described medicine is collutory, it is specially:

The first step, gets Radix Adenophorae, Folium Isatidis, Cortex Phellodendri, Rhizoma Panacis Majoris, Radix Sophorae Flavescentis, Galla Chinensis, Radix Scrophulariae, Myrrha, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici, mixes by described weight, be ground into 100 object powder, be 25 ~ 45MPa at pressure, temperature is under 40 ~ 50 DEG C of conditions, adopts supercritical CO ₂extract 1.5 ~ 2.5 hours, collect extract, extract adds determining alcohol 70 ~ 80% ethanol, is heated to 50 ~ 70 DEG C, constantly stirs, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, and separates out precipitation, filter, concentrating under reduced pressure, dry, pulverize into 200 object powder;

Second step, by remaining components by described weight mixing, obtains mixture, is ground into 100 object powder, be placed in the container of sealing, add the water relative to 2 ~ 4 times, mixture, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, pulverize into 200 object powder;

3rd step, the powder first step and second step prepared mixes, and obtains medicated powder, gets 100g medicated powder, 30g glucide, benzoic acid 3g, glycyrrhizic acid 3g, Oleum menthae 2g, 30g sodium lauryl sulphate and 1L water mix homogeneously, obtains collutory.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

The preparation of embodiment 1 collutory 1

Get Radix Adenophorae 40g, Folium Isatidis 55g, Cortex Phellodendri 35g, Rhizoma Panacis Majoris 45g, Radix Sophorae Flavescentis 40g, Galla Chinensis 40g, Radix Scrophulariae 30g, Myrrha 40g, Herba Taxilli 35g, Radix et Rhizoma Rhei Franzenbachii 35g, Radix seu Herba Gei aleppici 35g mix, be ground into 100 object powder, be 35MPa at pressure, temperature is under 50 DEG C of conditions, adopts supercritical CO ₂extract 2 hours, collect extract, extract adds determining alcohol 80% ethanol, be heated to 60 DEG C, continuous stirring, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, separate out precipitation, filter, concentrating under reduced pressure, dry, be ground into 200 object powder, by Caulis Sargentodoxae 25g, Lignum Sappan 25g, Folium Viticis Negundo 35g, Herba Lysimachiae 25g, Herba Eleusines Indicae 30g, Folium et Caulis Indigoferae Tinctoriae 25g, Caulis Lonicerae 30g, Herba Rabdosiae glaucocalycis 25g, Herba Asteris Ageratoidis 40g and Radix Caesalpiniae Radicis 25g mixes, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add the water of 900g, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, be ground into 200 object powder, by the powder mixing prepared above, obtain medicated powder, get 100g medicated powder, 30g glucide, benzoic acid 3g, glycyrrhizic acid 3g, Oleum menthae 2g, 30g sodium lauryl sulphate and 1L water mix homogeneously, obtain collutory 1.

The preparation of embodiment 2 collutory 2

Get Radix Adenophorae 45g, Folium Isatidis 60g, Cortex Phellodendri 40g, Rhizoma Panacis Majoris 50g, Radix Sophorae Flavescentis 45g, Galla Chinensis 45g, Radix Scrophulariae 35g, Myrrha 40g, Herba Taxilli 35g, Radix et Rhizoma Rhei Franzenbachii 35g, Radix seu Herba Gei aleppici 35g mix, be ground into 100 object powder, be 35MPa at pressure, temperature is under 50 DEG C of conditions, adopts supercritical CO ₂extract 2 hours, collect extract, extract adds determining alcohol 80% ethanol, be heated to 60 DEG C, continuous stirring, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, separate out precipitation, filter, concentrating under reduced pressure, dry, be ground into 200 object powder, by Caulis Sargentodoxae 30g, Lignum Sappan 30g, Folium Viticis Negundo 40g, Herba Lysimachiae 25g, Herba Eleusines Indicae 30g, Folium et Caulis Indigoferae Tinctoriae 25g, Caulis Lonicerae 30g, Herba Rabdosiae glaucocalycis 25g, Herba Asteris Ageratoidis 40g and Radix Caesalpiniae Radicis 25g mixes, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add the water of 900g, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, be ground into 200 object powder, by the powder mixing prepared above, obtain medicated powder, get 100g medicated powder, 30g glucide, benzoic acid 3g, glycyrrhizic acid 3g, Oleum menthae 2g, 30g sodium lauryl sulphate and 1L water mix homogeneously, obtain collutory 2.

The preparation of embodiment 3 collutory 3

Get Radix Adenophorae 40g, Folium Isatidis 55g, Cortex Phellodendri 35g, Rhizoma Panacis Majoris 45g, Radix Sophorae Flavescentis 40g, Galla Chinensis 40g, Radix Scrophulariae 30g, Myrrha 35g, Herba Taxilli 30g, Radix et Rhizoma Rhei Franzenbachii 30g, Radix seu Herba Gei aleppici 30g mix, be ground into 100 object powder, be 35MPa at pressure, temperature is under 50 DEG C of conditions, adopts supercritical CO ₂extract 2 hours, collect extract, extract adds determining alcohol 80% ethanol, be heated to 60 DEG C, continuous stirring, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, separate out precipitation, filter, concentrating under reduced pressure, dry, be ground into 200 object powder, by Caulis Sargentodoxae 25g, Lignum Sappan 25g, Folium Viticis Negundo 35g, Herba Lysimachiae 20g, Herba Eleusines Indicae 25g, Folium et Caulis Indigoferae Tinctoriae 20g, Caulis Lonicerae 25g, Herba Rabdosiae glaucocalycis 20g, Herba Asteris Ageratoidis 35g and Radix Caesalpiniae Radicis 20g mixes, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add the water of 900g, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, be ground into 200 object powder, by the powder mixing prepared above, obtain medicated powder, get 100g medicated powder, 30g glucide, benzoic acid 3g, glycyrrhizic acid 3g, Oleum menthae 2g, 30g sodium lauryl sulphate and 1L water mix homogeneously, obtain collutory 3.

The preparation of embodiment 4 dentifrice 1

Get Radix Adenophorae 40g, Folium Isatidis 55g, Cortex Phellodendri 35g, Rhizoma Panacis Majoris 45g, Radix Sophorae Flavescentis 40g, Galla Chinensis 40g, Radix Scrophulariae 30g, Myrrha 40g, Herba Taxilli 35g, Radix et Rhizoma Rhei Franzenbachii 35g, Radix seu Herba Gei aleppici 35g mix, be ground into 100 object powder, be 35MPa at pressure, temperature is under 50 DEG C of conditions, adopts supercritical CO ₂extract 2 hours, collect extract, extract adds determining alcohol 80% ethanol, be heated to 60 DEG C, continuous stirring, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, separate out precipitation, filter, concentrating under reduced pressure, dry, be ground into 200 object powder, by Caulis Sargentodoxae 25g, Lignum Sappan 25g, Folium Viticis Negundo 35g, Herba Lysimachiae 25g, Herba Eleusines Indicae 30g, Folium et Caulis Indigoferae Tinctoriae 25g, Caulis Lonicerae 30g, Herba Rabdosiae glaucocalycis 25g, Herba Asteris Ageratoidis 40g and Radix Caesalpiniae Radicis 25g mixes, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add the water of 900g, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, be ground into 200 object powder, by the powder mixing prepared above, obtain medicated powder, get medicated powder prepared by 150g, 2kg300 object calcium hydrogen phosphate, the sodium lauryl sulphate of 100g, 50g Oleum menthae, 5g sodium benzoate and 5g Margarita powder mix, obtain dentifrice 1.

The preparation of embodiment 5 dentifrice 2

Get Radix Adenophorae 45g, Folium Isatidis 60g, Cortex Phellodendri 40g, Rhizoma Panacis Majoris 50g, Radix Sophorae Flavescentis 45g, Galla Chinensis 45g, Radix Scrophulariae 35g, Myrrha 40g, Herba Taxilli 35g, Radix et Rhizoma Rhei Franzenbachii 35g, Radix seu Herba Gei aleppici 35g mix, be ground into 100 object powder, be 35MPa at pressure, temperature is under 50 DEG C of conditions, adopts supercritical CO ₂extract 2 hours, collect extract, extract adds determining alcohol 80% ethanol, be heated to 60 DEG C, continuous stirring, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, separate out precipitation, filter, concentrating under reduced pressure, dry, be ground into 200 object powder, by Caulis Sargentodoxae 30g, Lignum Sappan 30g, Folium Viticis Negundo 40g, Herba Lysimachiae 25g, Herba Eleusines Indicae 30g, Folium et Caulis Indigoferae Tinctoriae 25g, Caulis Lonicerae 30g, Herba Rabdosiae glaucocalycis 25g, Herba Asteris Ageratoidis 40g and Radix Caesalpiniae Radicis 25g mixes, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add the water of 900g, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, be ground into 200 object powder, by the powder mixing prepared above, obtain medicated powder, get medicated powder prepared by 150g, 2kg300 object calcium hydrogen phosphate, the sodium lauryl sulphate of 100g, 50g Oleum menthae, 5g sodium benzoate and 5g Margarita powder mix, obtain dentifrice 2.

The preparation of embodiment 6 dentifrice 3

Get Radix Adenophorae 40g, Folium Isatidis 55g, Cortex Phellodendri 35g, Rhizoma Panacis Majoris 45g, Radix Sophorae Flavescentis 40g, Galla Chinensis 40g, Radix Scrophulariae 30g, Myrrha 35g, Herba Taxilli 30g, Radix et Rhizoma Rhei Franzenbachii 30g, Radix seu Herba Gei aleppici 30g mix, be ground into 100 object powder, be 35MPa at pressure, temperature is under 50 DEG C of conditions, adopts supercritical CO ₂extract 2 hours, collect extract, extract adds determining alcohol 80% ethanol, be heated to 60 DEG C, continuous stirring, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, separate out precipitation, filter, concentrating under reduced pressure, dry, be ground into 200 object powder, by Caulis Sargentodoxae 25g, Lignum Sappan 25g, Folium Viticis Negundo 35g, Herba Lysimachiae 20g, Herba Eleusines Indicae 25g, Folium et Caulis Indigoferae Tinctoriae 20g, Caulis Lonicerae 25g, Herba Rabdosiae glaucocalycis 20g, Herba Asteris Ageratoidis 35g and Radix Caesalpiniae Radicis 20g mixes, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add the water of 900g, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, be ground into 200 object powder, by the powder mixing prepared above, obtain medicated powder, get medicated powder prepared by 150g, 2kg300 object calcium hydrogen phosphate, the sodium lauryl sulphate of 100g, 50g Oleum menthae, 5g sodium benzoate and 5g Margarita powder mix, obtain dentifrice 3.

Embodiment 7 toxicological experiment

Acute toxicity testing

Mice is divided at random test group and blank group, each 20.Before test after fasting (can't help water) 12h, the test group collutory 1 that every day is prepared by 1 gastric infusion embodiment 1, blank group is filled with to normal saline.Continuous 14d, the situations such as the behavior of record test mice, activity, food ration, body weight, feces, death, not dead mice is put to death and performs an autopsy on sb. after 14d.

The mice of drug test group 40g (crude drug)/kg dosed administration, saw that mice hair color was smooth, feces is brown the same day, quality is rarer soft, ingest, movable less, mice activity after 2nd day, food ration, body weight growth, feces etc. all recover normally, to compare no significant difference with blank group; And in 14d without dead and other extremely to occur, two groups put to death simultaneously after perform an autopsy on sb., each main organs (heart, liver, spleen, lung, kidney) no abnormality seen by the naked eye.

Long term toxicity test

Rat is divided at random test group and blank group, each 20.The test group collutory 1 that every day is prepared by 1 gastric infusion embodiment 1, the time of repetitively administered is 5 weeks, and test group dosage is 10g (crude drug)/kg.Experimental animal behavioral activity, diet, defecation and shown no obvious abnormalities by situations such as hair color pools within whole experimental period, have no vomiting, sialorrhea, shed tears, the symptom such as dyspnea.

The solution portion of rat main organs learns and observes: put to death animal after off-test, dissect immediately, the major organs such as perusal brain, heart, liver, spleen, lungs, kidney, each organ surface is smooth, without adhesion, color and luster is normal, has no hyperemia, swelling, hemorrhage, downright bad, adhesion, gastrointestinal is without expansion, and intestinal wall is without abnormal phenomenas such as edema, hemorrhage, ulcer.

Histopathologic examination's result

Heart: myocardial cell band is clear, core is placed in the middle, and interstitial has no vasodilation and cell infiltration; Visceral pericardium, endocardium are without exception.Liver: hepatocyte arrangement is in strand, and lobules of liver structure is clear, and portal area has no cell infiltration and fibrous connective tissue hypertrophy, hepatocyte polygon, and slurry is abundant, core is large and justify.Spleen: fibrous capsule is complete, without thickening, acini lienalis is high-visible, and trabecularism is normal, and red pulp, white pulp are clear, have no degeneration, necrosis and cell infiltration.Lungs: bronchioles structural integrity, is methodically arranged, alveolar wall structural integrity, lung interval and bronchus stand intact, and intracavity, without obvious exudate, has no degeneration, necrosis and cell infiltration.Kidney: Renal Cortex, medullary substance, glomerule structure are normal, and messangial cell number does not increase, blood capillary tube chamber without expansion, renal cells, renal interstitial no abnormality seen.Brain: organizational structure is normal, neurocyte, neurogliocyte form are normal, each layer neuronal cell Non Apparent Abnormality.

Irritation test

By healthy adult white, man exempts from 4, body weight 2.5 ~ 2.7kg, male and female half and half.By its spinal column both sides skin unhairing 3cm × 3cm, collutory 1 prepared by Example 1,2.5cm × 2.5cm bis-layers of gauze are immersed in 10min in this collutory, be applied on a plucked skin in rabbit back side subsequently, cover with one deck cellophane, fixed with nonirritant medical proof fabric and binder, opposite side distilled water compares again.Every experimental animal is applied ointment or plaster after 4h, removes tested material, with the skin of warm water cleaning application site, respectively at 1,24,48h observes and records the dermoreaction of application site, the standards of grading specified according to " disinfection technology standard " and classification are marked.Irritation test shows, Chinese medicine mouth wash provided by the invention 1 pair of rabbit skin wound repair integration is 0, and skin, without erythema, belongs to non-stimulated.

Animal level is tested

Animal subject

SD rat, male and female half and half, body weight 250g ~ 300g, for 30.

Equipment

Multi-channel laser Doppler flow instrument PeriFlux4001 type, purchased from PERIMED company of Sweden.7150 type automatic biochemistry analyzers, purchased from Hitachi, Ltd.

Modeling process

Experiment is divided into matched group, model group and treatment group, often organizes 10 rats, and model group and treatment group tie the two lower incisor neck portion of rat with silk thread under pentobarbital sodium anesthesia, and on gingiva, stitches two pins fix, and Post operation is fed normal mice material, drinks 10% sucrose water.Matched group is only anaesthetized, and does not tie neck portion, gives normal mice material and ordinary water.After model group and treatment group modeling, 7d carries out gingiva regional flow mensuration and level in gingival sulcus fluid AST assay.After modeling success, the collutory of the treatment group rats gavaged embodiment of the present invention 1 preparation, the amount of gavaging is 0.8ml/g, after gavaging 7d, again carries out gingiva regional flow mensuration and level in gingival sulcus fluid AST assay.

Measure

Regional flow is detected

By on rearmounted for rat anesthesia operating-table, laser doppler flow probe is fixed on the locating rack of brain solid positioner, regulates probe orientation vertical with lower incisor gingival mucosa surface and contacts gently, the blood flow of record 2min.Instrument can calculate mean blood flow, blood flow rate and cell number automatically.

Level in gingival sulcus fluid AST assay

The filter paper bar getting 2mm × 4mm is placed in gingival mucosa surface 60s between two lower incisors, takes out filter paper, drops into and be equipped with in the micro-centrifuge tube of 0.5mL normal saline, suspendible device shakes 60s ,-70 DEG C of preservations, adopt automatic clinical chemistry analyzer to measure AST in 1 week.Adopting precision balance to weigh the change of filter paper quality simultaneously, drawing the quality of level in gingival sulcus fluid, for correcting gingival crevicular fluid.

Statistics

All experimental datas with ± s represents, utilizes SPSS11.0 statistical software, its significance of t inspection inspection between employing group.

Result

In table 1.

The change of table 1 Rat Experimental gingivitis regional flow and level in gingival sulcus fluid AST level

The congested redness of model group animal gingiva has ulcer and shallow periodontal pocket to be formed, and gingiva regional blood flow and blood flow rate have the trend of increase.Model group blood cell count significantly raises (P < 0.05).Gingivitis rat level in gingival sulcus fluid AST content is significantly higher than matched group (P < 0.001), treatment group is compared with model group, blood flow, blood flow rate, blood cell count and AST content all significantly decline, close to contrast class value, prove to adopt medicine provided by the invention to have significant effect in treatment gingivitis.

Clinical data

Tested crowd

Select volunteer 160 people, clinical be divided at random treatment group 80 example and western medicine group 80 routine.Wherein treatment group man 41 example, female 39 example, 15 ~ 60 years old age.The course of disease is the longest 9 years, the shortest 5d, average 2 years 7 months, and matched group man 43 example, female 37 example, at 18 ~ 60 years old age, the course of disease is the longest 8 years, the shortest 6d, average course of disease 2 years 10 months.

Inclusive criteria

Systemic conditions is good; 15 natural teeth are at least had in oral cavity; Without untreated dental caries, dental pulp and tip of a root pathological changes; Expection can complete this test and be ready to avoid during this period using other non-test dental care products.

Exclusion standard: oral mucosa has the focus needing treatment; Dentures repai or wear with orthodontic appliance; Ill fitting prosthesis is had in oral cavity; Took antibiotic before baseline inspection in 2 weeks or in 6 weeks, took any Cyclomycin family antibiotic person; Suffer from diabetes, hepatitis B, tuberculosis or other infection or metabolic disease; Allergies are had to oral-cavity cleaning products; Need to use any medicine person likely causing gingiva to react.

Diagnostic criteria is with reference to the diagnostic criteria about gingivitis in " periodontal " of Cao Caifang chief editor.

Observation index:

Gingival index (GI): adopt improvement Loe-Silness method to measure GI.Gingivitis point system and standard: 0 is divided into NIP; 1 is divided into mild inflammation, and gingiva color and luster and quality slightly change, but spy is examined without hemorrhage; 2 are divided into moderate inflammation, gingiva light, red, swollen, hypertrophy, and spy is examined hemorrhage; 3 are divided into hyperphlogosis, and gingiva is rubescent, hypertrophy obviously, has hematostaxis.GI value calculates by following formula: the summation/measurement tooth face number of all tooth scoring value of GI=.

Plaque index (PLI): adopt Quigley-Hein to improve Turesky method and evaluate supragingival plaque.Supragingival plaque is dyeed, and scores according to following standard: 0 is divided into without bacterial plaque; 1 bacterial plaque being divided into neck portion marginal existence to be dispersed in; 2 are divided into the thin bacterial plaque band (reaching 1mm wide) of the visible continuous print in neck edge; 3 are divided into neck portion bacterial plaque band to be greater than 1Mm, but are less than 1/3 of facing; 4 are divided into bacterial plaque to cover the 1/3-2/3 of facing; 5 are divided into bacterial plaque to cover facing more than 2/3.Whole tooth detection gained score sum/measurement tooth number (tooth number × 2) of PLI=every experimenter.

Selection 11,25,26,31,45,46 totally 6 tooth positions observes tooth for specifying, each tooth detection 4 facings, i.e. nearly middle cheek (lip) face, cheek (lip) face, middle cheek (lip) face far away and lingual surface, score as the meansigma methods of scoring by inspection tooth, detect its GI, PLI when patients is monthly checked, carry out statistical analysis.

Medicine

Treatment group: collutory 1 prepared by embodiment 1, usage: every day 3 after the meal with dinner before brush teeth with clear water after with this medicinal liquid rinsing the mouth, each 20ml, repeatedly rinsing the mouth 3min, at least do not drink water, do not eat food, gargle again without clear water, extend drug effect as far as possible in 2h; 10d is 1 course for the treatment of.

Matched group: 1:5000 furacillin solution rinsing the mouth, detailed directions consumption is with collutory 1.

Oral cavity cleaning method

After baseline checks, oral cavity basis scaling is carried out to whole experimenter.Require the mouthwash of experimenter's treatment group every day or matched group.Duration of test can not oral-cavity cleaning products beyond service test, does not carry out oral hygiene guidance to experimenter.12 weeks and 24 weeks time check dental plaque index and index of gingivitis.

General curative effect standard

" periodontal " with reference to Cao Caifang chief editor draft into, cure: pain disappears, and plaque index all declines 0, and gingival abscess disappears, outward appearance recovers normal; Effective: pain relief, plaque index all drops to 1, and gingival abscess disappears, and outward appearance recovers normal substantially; Effective: pain relief, plaque index all drops to 2 or 3, and outward appearance makes moderate progress; Invalid: sings and symptoms is without significant change.

Statistics

All experimental datas with ± s represents, utilizes SPSS11.0 statistical software, its significance of t inspection inspection between employing group.

Result

In table 2 to table 4.

Table 2 liang group gingivitis indices mean is in the comparison of baseline, 12 weeks and 24 weeks

Group	n	Baseline	12 weeks	24 weeks
					Treatment group	80	1.61± 0.20	0.93± 0.17	0.71± 0.09
Matched group	80	1.62± 0.17	1.30± 0.25	1.06± 0.19

Table 2 show two groups of experimenters baseline, 12 weeks and 24 weekly check time gingivitis indices mean situation of change.When baseline checks, the index of gingivitis mean of two groups compares not statistically significant.During 12 weekly check, the gingivitis indices mean of two groups is all decreased significantly, and during 24 weekly check, treatment group index decreased comparatively matched group comparing difference has statistical significance (P<0.05).

Table 3 liang group gingivitis indices mean is in the comparison of baseline, 12 weeks and 24 weeks

Group	n	Baseline	12 weeks	24 weeks
					Treatment group	80	2.77± 0.31	1.53± 0.36	0.90± 0.23
Matched group	80	2.79± 0.29	2.21± 0.29	1.53± 0.37

Table 3 show two groups of experimenters baseline, 12 weeks and 24 weekly check time dental plaque index mean situation of change.When baseline checks, the dental plaque index mean of two groups compares not statistically significant.During 12 weekly check, the dental plaque index mean of two groups is all decreased significantly, and during 24 weekly check, treatment group index decreased comparatively matched group comparing difference has statistical significance (P<0.05).

Table 4 general curative effect compares

Group	n	Cure	Effective	Effectively	Invalid	Total effective rate
							Treatment group	80	23	39	15	3	96.3%
Matched group	80	6	35	31	8	90.0%

As can be seen from Table 4, adopt medication effect provided by the invention will significantly better than western medicine.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. be used for the treatment of a medicine for gingivitis, it is characterized in that: crude drug comprises Radix Adenophorae, Folium Isatidis, Cortex Phellodendri, Caulis Sargentodoxae, Rhizoma Panacis Majoris, Lignum Sappan, Folium Viticis Negundo, Radix Sophorae Flavescentis, Galla Chinensis, Radix Scrophulariae, Herba Lysimachiae, Herba Eleusines Indicae, Folium et Caulis Indigoferae Tinctoriae, Myrrha, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici, Caulis Lonicerae, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis and Radix Caesalpiniae Radicis.

2. medicine as claimed in claim 1, it is characterized in that: the weight of each crude drug is respectively Radix Adenophorae 35g ~ 45g, Folium Isatidis 50g ~ 60g, Cortex Phellodendri 30g ~ 40g, Caulis Sargentodoxae 20g ~ 30g, Rhizoma Panacis Majoris 40g ~ 50g, Lignum Sappan 20g ~ 30g, Folium Viticis Negundo 30g ~ 40g, Radix Sophorae Flavescentis 35g ~ 45g, Galla Chinensis 35g ~ 45g, Radix Scrophulariae 25g ~ 35g, Herba Lysimachiae 20g ~ 30g, Herba Eleusines Indicae 25g ~ 35g, Folium et Caulis Indigoferae Tinctoriae 20g ~ 30g, Myrrha 35g ~ 45g, Herba Taxilli 30g ~ 40g, Radix et Rhizoma Rhei Franzenbachii 30g ~ 40g, Radix seu Herba Gei aleppici 30g ~ 40g, Caulis Lonicerae 25g ~ 35g, Herba Rabdosiae glaucocalycis 20g ~ 30g, Herba Asteris Ageratoidis 35g ~ 45g and Radix Caesalpiniae Radicis 20g ~ 30g.

3. medicine as claimed in claim 1 or 2, it is characterized in that: the weight of each crude drug is respectively Radix Adenophorae 40g ~ 45g, Folium Isatidis 55g ~ 60g, Cortex Phellodendri 35g ~ 40g, Caulis Sargentodoxae 25g ~ 30g, Rhizoma Panacis Majoris 45g ~ 50g, Lignum Sappan 25g ~ 30g, Folium Viticis Negundo 35g ~ 40g, Radix Sophorae Flavescentis 40g ~ 45g, Galla Chinensis 40g ~ 45g, Radix Scrophulariae 30g ~ 35g, Herba Lysimachiae 20g ~ 25g, Herba Eleusines Indicae 25g ~ 30g, Folium et Caulis Indigoferae Tinctoriae 20g ~ 25g, Myrrha 35g ~ 40g, Herba Taxilli 30g ~ 35g, Radix et Rhizoma Rhei Franzenbachii 30g ~ 35g, Radix seu Herba Gei aleppici 30g ~ 35g, Caulis Lonicerae 25g ~ 30g, Herba Rabdosiae glaucocalycis 20g ~ 25g, Herba Asteris Ageratoidis 35g ~ 40g and Radix Caesalpiniae Radicis 20g ~ 25g.

4. the medicine as described in claims 1 to 3, is characterized in that: the weight of each crude drug is respectively Radix Adenophorae 40g, Folium Isatidis 55g, Cortex Phellodendri 35g, Caulis Sargentodoxae 25g, Rhizoma Panacis Majoris 45g, Lignum Sappan 25g, Folium Viticis Negundo 35g, Radix Sophorae Flavescentis 40g, Galla Chinensis 40g, Radix Scrophulariae 30g, Herba Lysimachiae 25g, Herba Eleusines Indicae 30g, Folium et Caulis Indigoferae Tinctoriae 25g, Myrrha 40g, Herba Taxilli 35g, Radix et Rhizoma Rhei Franzenbachii 35g, Radix seu Herba Gei aleppici 35g, Caulis Lonicerae 30g, Herba Rabdosiae glaucocalycis 25g, Herba Asteris Ageratoidis 40g and Radix Caesalpiniae Radicis 25g.

5. the medicine as described in Claims 1-4, is characterized in that: described medicine is external used medicine.

6. the medicine as described in claim 1 to 5, is characterized in that: described medicine is dentifrice or collutory.

7. the preparation method of medicine described in claim 1 to 6, is characterized in that: when the dosage form of described medicine is dentifrice, be specially,

The first step, gets Radix Adenophorae, Folium Isatidis, Cortex Phellodendri, Rhizoma Panacis Majoris, Radix Sophorae Flavescentis, Galla Chinensis, Radix Scrophulariae, Myrrha, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici, mixes by described weight, be ground into 100 object powder, be 25 ~ 45MPa at pressure, temperature is under 40 ~ 50 DEG C of conditions, adopts supercritical CO ₂extract 1.5 ~ 2.5 hours, collect extract, extract adds determining alcohol 70 ~ 80% ethanol, is heated to 50 ~ 70 DEG C, constantly stirs, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, and separates out precipitation, filter, concentrating under reduced pressure, dry, pulverize into 200 object powder;

Second step, by remaining components by described weight mixing, obtains mixture, is ground into 100 object powder, be placed in the container of sealing, add the water relative to 2 ~ 4 times, mixture, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, pulverize into 200 object powder;

3rd step, the powder first step and second step prepared mixes, and obtains medicated powder, gets medicated powder prepared by 150g, 2kg300 object calcium hydrogen phosphate, the sodium lauryl sulphate of 100g, 50g Oleum menthae, 5g sodium benzoate and 5g Margarita powder and mixes, obtain dentifrice.

8. the preparation method of medicine described in claim 1 to 6, is characterized in that: when the dosage form of described medicine is collutory, be specially,

The first step, gets Radix Adenophorae, Folium Isatidis, Cortex Phellodendri, Rhizoma Panacis Majoris, Radix Sophorae Flavescentis, Galla Chinensis, Radix Scrophulariae, Myrrha, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici, mixes by described weight, be ground into 100 object powder, be 25 ~ 45MPa at pressure, temperature is under 40 ~ 50 DEG C of conditions, adopts supercritical CO ₂extract 1.5 ~ 2.5 hours, collect extract, extract adds determining alcohol 70 ~ 80% ethanol, is heated to 50 ~ 70 DEG C, constantly stirs, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, and separates out precipitation, filter, concentrating under reduced pressure, dry, pulverize into 200 object powder;

Second step, by remaining components by described weight mixing, obtains mixture, is ground into 100 object powder, be placed in the container of sealing, add the water relative to 2 ~ 4 times, mixture, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, concentrating under reduced pressure, dry, pulverize into 200 object powder;

3rd step, the powder first step and second step prepared mixes, and obtains medicated powder, gets 100g medicated powder, 30g glucide, benzoic acid 3g, glycyrrhizic acid 3g, Oleum menthae 2g, 30g sodium lauryl sulphate and 1L water mix homogeneously, obtains collutory.