CN113230165A

CN113230165A - A collutory containing marrubium vulgare extract with antiinflammatory and antibacterial effects

Info

Publication number: CN113230165A
Application number: CN202110358860.2A
Authority: CN
Inventors: 桑苏君
Original assignee: Beijing Shengyong Pharmaceutical Co ltd
Current assignee: Beijing Shengyong Pharmaceutical Co ltd
Priority date: 2021-04-02
Filing date: 2021-04-02
Publication date: 2021-08-10
Anticipated expiration: 2041-04-02
Also published as: CN113230165B

Abstract

The invention discloses a mouthwash containing an origanum vulgare extract and having an anti-inflammatory and bactericidal function, which comprises the following components in percentage by mass: marrubium vulgare extract: 0.05-0.5%, sodium azulene sulfonate: 0.01-1%, 0.3-2% of flavoring agent, 0.1-1% of preservative, 2-10% of plant extract, 1-5% of ethanol and the balance of deionized water; the plant extract comprises flos Lonicerae, flos Chrysanthemi, Notoginseng, Coptidis rhizoma, herba Portulacae, and folium Isatidis; the weight ratio of the honeysuckle to the chrysanthemum to the pseudo-ginseng flower to the coptis chinensis to the purslane to the folium isatidis is 7:8:6:2:6: 9; according to the mouthwash provided by the invention, the plant extract containing honeysuckle, chrysanthemum, pseudo-ginseng flower, coptis, purslane and folium isatidis, the marrubium vulgare extract and the sodium azulene sulfonate are added into the formula, so that the mouthwash has a good sterilization and anti-inflammation effect, can obviously improve the oral inflammation of a user, and has a good breath freshening effect.

Description

A collutory containing marrubium vulgare extract with antiinflammatory and antibacterial effects

Technical Field

The invention relates to a daily chemical product, in particular to a mouthwash containing an marrubium vulgare extract with anti-inflammatory and bactericidal functions.

Background

With the development of the economic society and the improvement of the living standard of people, the dietary structure of people is changed, and various oral diseases corresponding to the dietary structure are more and more common. At present, the incidence rate of oral diseases is extremely high, the types of oral diseases are also various, such as oral ulcer, pharyngitis, laryngitis, tonsillitis, gingivitis and the like, particularly recurrent oral ulcer patients have the characteristic of periodical and repeated attacks, the work and life of the people are seriously affected, and the prevention and treatment of oral diseases and the protection of teeth are particularly important.

The mouthwash is one of the ways of cleaning oral health, can inhibit the growth of bacterial plaque, improve the problems of teeth and gum and promote the oral health, and although the mouthwash cannot replace tooth brushing, the tooth brushing of 2-3 times a day is not enough to achieve good oral and tooth protection effects, so the mouthwash is often used as an auxiliary means besides tooth brushing.

So far, the types of mouthwashes in the market are more, including non-medicinal and medicinal mouthwashes, but some defects exist in throwing, such as poor breath freshening effect and incapability of effectively covering halitosis; the sterilizing and inflammation diminishing effects are not ideal, and the oral inflammation is not obviously improved, and the like, and needs to be improved.

Disclosure of Invention

The invention aims to provide a mouthwash containing an marrubium vulgare extract with anti-inflammatory and bactericidal functions, so as to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

a mouthwash containing an Erysia europaea extract with anti-inflammatory and bactericidal functions comprises the following components in percentage by mass: marrubium vulgare extract: 0.05-0.5%, sodium azulene sulfonate: 0.01-1%, 0.3-2% of flavoring agent, 0.1-1% of preservative, 2-10% of plant extract, 1-5% of ethanol and the balance of deionized water;

the plant extract is prepared from flos Lonicerae, flos Chrysanthemi, Notoginseng, Coptidis rhizoma, herba Portulacae, and folium Isatidis;

the weight ratio of the honeysuckle to the chrysanthemum to the pseudo-ginseng flower to the coptis chinensis to the purslane to the folium isatidis is 7:8:6:2:6: 9;

the preparation method of the plant extract comprises the following steps:

step a: selecting, cleaning and drying honeysuckle, chrysanthemum, pseudo-ginseng flower, coptis, purslane and folium isatidis, and mixing according to a formula ratio to obtain a raw material A;

step b: weighing raw material A in required weight parts, crushing and mixing to obtain raw material B;

step c: adding pure water into the raw material B, decocting until the material-liquid ratio is 1:5, and filtering to obtain a supernatant A and medicine residues;

step d: adding pure water into the dregs of a decoction, decocting until the material-liquid ratio is 1:3, and filtering to obtain supernatant B;

step e: mixing the supernatant A and B at a ratio of 2:1, evaporating to 3/5 of the stock solution, and cooling to obtain plant extractive solution.

As a further scheme of the invention: the composite material comprises the following components in percentage by mass: marrubia oldhamiana extract: 0.01-0.3%, sodium azulene sulfonate: 0.05-0.5% of flavoring agent, 0.5-1.5% of preservative, 3-8% of plant extract, 2-4% of ethanol and the balance of deionized water.

As a further scheme of the invention: the composite material comprises the following components in percentage by mass: marrubia oldhamiana extract: 0.1%, sodium azulene sulfonate: 0.05 percent of flavoring agent, 1.2 percent of preservative, 0.3 percent of plant extract, 3 percent of ethanol and the balance of deionized water.

As a further scheme of the invention: the flavoring agent comprises a sweetening agent and a cooling agent, wherein the ratio of the sweetening agent to the cooling agent is 2: 3.

as a further scheme of the invention: the sweetener is one or combination of stevioside, liquorice, disodium glycyrrhizinate, tripotassium glycyrrhizinate and trisodium glycyrrhizinate.

As a further scheme of the invention: the cooling agent is one or the combination of WS-3, WS-5, WS-10, WS-12 and WS-23.

As a further scheme of the invention: the preservative comprises methyl paraben and allantoin, wherein the weight ratio of the methyl paraben to the allantoin is 1: 2.

As a further scheme of the invention: in the step a, the water content of the dried raw materials is less than 5%.

As a further scheme of the invention: in the step B, the particle diameter of the raw material B is less than 60 meshes.

As a further scheme of the invention: in the step c, the ratio of materials to liquid before decoction is 1:10, the decoction process is to carry out high-pressure decoction for 20-30min firstly and then carry out normal-pressure decoction until the ratio of materials to liquid is 1: 5.

As a further scheme of the invention: the decocting pressure of the high-pressure decoction is 85-90Kpa, and the decocting temperature is 115-125 ℃.

As a further scheme of the invention: in the step d, the ratio of materials to liquid before decoction is 1: 6.

The preparation method of the mouthwash containing the marrubium vulgare extract with the anti-inflammatory and bactericidal functions comprises the following steps:

the method comprises the following steps: weighing the marrubium vulgare extract, sodium azulene sulfonate, a flavoring agent, a preservative, a plant extracting solution, ethanol and deionized water in required parts by weight according to a formula;

step two: adding sodium azulene sulfonate, a flavoring agent, a preservative and ethanol into deionized water, and stirring for 3-5min to obtain a solution A;

step three: adding the plant extract into the solution A, stirring with ultrasonic wave for 5-10min, standing, and defoaming to obtain the collutory.

Compared with the prior art, the invention has the beneficial effects that:

according to the mouthwash provided by the invention, the plant extract containing honeysuckle, chrysanthemum, pseudo-ginseng flower, coptis, purslane and folium isatidis, the marrubium vulgare extract and the sodium azulene sulfonate are added into the formula, so that the mouthwash has a good sterilization and anti-inflammation effect, can obviously improve the oral inflammation of a user, and has a good breath freshening effect.

Detailed Description

In order to make the technical problems, technical solutions and advantageous effects of the present invention more apparent, the present invention will be described in further detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.

It will be understood that the terms "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used merely to facilitate describing the invention and to simplify the description, and do not indicate or imply that the referenced devices or elements must be constructed and operated in a particular orientation within the specification and are not to be considered limiting of the invention.

Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or an implicit indication of the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.

In the embodiment of the invention, the mouthwash containing the marrubium vulgare extract with the anti-inflammatory and bactericidal functions comprises the following components in percentage by mass: marrubium vulgare extract: 0.05-0.5%, sodium azulene sulfonate: 0.01-1%, 0.3-2% of flavoring agent, 0.1-1% of preservative, 2-10% of plant extract, 1-5% of ethanol and the balance of deionized water;

the sodium azulene sulfonate is an anti-inflammatory and anti-ulcer medicine with little side effect, has good treatment effect on common oral diseases, and can effectively eliminate symptoms such as edema, blood filling, abscess, gingival bleeding, halitosis, odontoseisis and the like caused by the common oral diseases. Pharmacological research on sodium azulene sulfonate shows that the sodium azulene sulfonate has a non-steroidal anti-inflammatory effect and an anti-adhesive film ulcer effect, and the main pharmacology is as follows: diminish inflammation, promote mucosa metabolism and epidermis formation, but has weak antibacterial effect. The sodium azulene sulfonate is added into the common toothpaste to be used in the oral cavity, which does not destroy the normal oral cavity flora balance and has good treatment effect on inflammatory reactions such as red, swelling, heat, pain and the like in the oral cavity.

The marrubium vulgare is also called yue fu grass, belongs to the marrubium vulgare, has the smell like thyme, has square stems, is mainly distributed in Yili areas of Xinjiang in China, and can be used for treating chronic diseases of respiratory organs in the aspect of medicine and can also be used as a substitute of Jinji naoshan cream skin; meanwhile, the marrubium vulgare extract can calm and soothe, detoxify and expel toxin, reduce the phenomenon of blood vessel congestion, effectively resist histamine and eliminate allergen.

wherein, the honeysuckle has the functions of resisting pathogenic microorganism, resisting virus, resisting inflammation, promoting inflammatory endocytosis function and the like;

the coptis chinensis has the effects of clearing heat, removing dampness, purging fire and removing toxin, and has good sterilizing and inflammation diminishing effects;

the purslane has good effects of inducing diuresis to alleviate edema, eliminating dust toxin and preventing degeneration and necrosis of phagocytes, contains more carotene, can promote healing of ulcer, and has strong inhibiting effect on bacilli dysentery, typhoid bacillus and escherichia coli.

the preparation method of the plant extract comprises the following steps:

The flavoring agent comprises a sweetening agent and a cooling agent, and the ratio of the sweetening agent to the cooling agent is 2: 3.

the sweetener is one or combination of stevioside, liquorice, disodium glycyrrhizinate, tripotassium glycyrrhizinate and trisodium glycyrrhizinate.

The cooling agent is one or a combination of WS-3, WS-5, WS-10, WS-12 and WS-23.

The preservative comprises methyl paraben and allantoin, wherein the weight ratio of the methyl paraben to the allantoin is 1: 2.

Among them, allantoin is a hydantoin derivative, has good bactericidal action, and when used as a preservative for mouthwash, it can not only prevent organic components in mouthwash from putrefaction and deterioration, but also kill harmful bacteria in oral cavity when using mouthwash, and has physiological functions of promoting cell growth, accelerating wound healing, softening keratin, and the like.

In the step a, the water content of the dried raw materials is less than 5%.

In the step B, the particle diameter of the raw material B is less than 60 meshes.

In the step c, the ratio of materials to liquid before decoction is 1:10, the decoction process is to carry out high-pressure decoction for 20-30min firstly and then carry out normal-pressure decoction until the ratio of materials to liquid is 1: 5.

The decocting pressure of the high-pressure decoction is 85-90Kpa, and the decocting temperature is 115-125 ℃.

In the step d, the ratio of materials to liquid before decoction is 1: 6.

Example 1:

preparing a plant extracting solution:

step a: selecting, cleaning and drying honeysuckle, chrysanthemum, pseudo-ginseng flower, coptis, purslane and folium isatidis, and mixing according to a formula proportion to obtain a raw material A, wherein the water content of the raw material A is less than 5%;

step b: weighing raw material A in required weight parts, crushing and mixing to obtain raw material B, wherein the particle diameter of the raw material B is less than 60 meshes;

step c: adding pure water into the raw material B until the liquid-material ratio is 1:10, then decocting for 20-30min at the temperature of 115 ℃ and 125 ℃ under the pressure of 85-90Kpa, then decocting at normal pressure until the material-liquid ratio is 1:5, and filtering to obtain a supernatant A and medicine residues;

step d: adding pure water into the dregs of a decoction until the liquid-material ratio is 1:6, decocting at normal pressure until the liquid-material ratio is 1:3, and filtering to obtain a supernatant B;

Preparing the mouthwash:

weighing an eriocaulon henryi extract: 0.1 part, sodium azulene sulfonate: 0.05 part of flavoring agent, 1.2 parts of flavoring agent, 0.3 part of preservative, 5 parts of plant extract and 3 parts of ethanol, weighing deionized water to 100 parts, adding sodium azulene sulfonate, flavoring agent, preservative and ethanol into deionized water, stirring for 3-5min to obtain solution A, then adding the plant extract into the solution A, stirring for 5-10min by ultrasonic waves, standing and defoaming to obtain the mouthwash.

Example 2:

the difference between the present example and example 1 is that the formula ratio is: 0.2 part, sodium azulene sulfonate: 0.1 part, 1.5 parts of flavoring agent, 0.4 part of preservative, 6 parts of plant extract and 4 parts of ethanol, and deionized water is weighed to 100 parts.

Comparative example 1:

the comparative example differs from example 1 in that no plant extract was added to the formulation.

Comparative example 2:

the difference between this comparative example and example 1 is that the formula does not contain marrubium vulgare extract and sodium olsulfonat.

Comparative example 3:

this comparative example differs from example 1 in that: the content of the plant extract in the formula is 2 parts.

Comparative example 4:

commercially available mouthwashes of a certain brand.

Effect test:

test 1:

60 volunteers with obvious halitosis and 60 volunteers who just smoked are selected for detection, one group of 10 persons is distributed with the mouthwash provided in examples 1 and 2 and comparative examples 1-4, and the following tests are carried out:

test 1: exhaling to a tester beyond the distance of 0.5m, and recording the breath sense organ and scoring by the tester;

and (3) testing 2: after the test 1 is finished, immediately using the corresponding mouthwash to rinse for 2min, and after 10min, exhaling again to the testers at a distance of 0.5m, and recording the score of the mouth feeling by the testers;

score was 5 points: fresh breath, no peculiar smell in conversation; and 4, dividing: the breath is fresh, and slight peculiar smell is generated in conversation; and 3, dividing: the conversation has peculiar smell and is obviously improved; and 2, dividing: the talk peculiar smell is obvious and slightly improved; 1 minute: the peculiar smell of conversation is obvious and is not improved.

The resulting score averages are shown in table 1:

TABLE 1

As can be seen from Table 1, the mouthwashes provided by examples 1 and 2 and comparative examples 1 to 3 of the present invention have good breath freshening effect, and are significantly better than commercially available mouthwashes of certain brands.

Test 2: bacteriostatic effect

The sterilization effect test method comprises the following steps: uniformly coating the bacterial liquid of (1-5) multiplied by 104cfu/g on a flat plate, and then uniformly coating the mouthwash prepared in examples 1 and 2 and comparative examples 1-4 on the surface of the flat plate; the incubation time was 5min, and the number of viable bacteria (in cfu/g) on the plate was measured and compared with the number of bacteria in the original bacterial solution to obtain the sterilization rate (%).

TABLE 2

As can be seen from the data in table 2, the mouthwash prepared according to the embodiment of the present invention has a good bactericidal effect by adding the plant extract, the alpinia arguta extract, and the sodium azulene sulfonate to the formula.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes, modifications, equivalents, and improvements can be made without departing from the spirit and scope of the invention.

Claims

1. A mouthwash containing an extract of marrubium vulgare with anti-inflammatory and bactericidal functions is characterized in that: the composite material comprises the following components in percentage by mass: marrubium vulgare extract: 0.05-0.5%, sodium azulene sulfonate: 0.01-1%, 0.3-2% of flavoring agent, 0.1-1% of preservative, 2-10% of plant extract, 1-5% of ethanol and the balance of deionized water;

the plant extract comprises flos Lonicerae, flos Chrysanthemi, Notoginseng, Coptidis rhizoma, herba Portulacae, and folium Isatidis;

the preparation method of the plant extract comprises the following steps:

step d: adding pure water into the dregs of a decoction, decocting until the material-liquid ratio is 1:3, and filtering to obtain a supernatant B;

2. The anti-inflammatory and antibacterial mouthwash containing the marrubium vulgare extract as claimed in claim 1, wherein: the composite material comprises the following components in percentage by mass: marrubium vulgare extract: 0.01-0.3%, sodium azulene sulfonate: 0.05-0.5% of flavoring agent, 0.5-1.5% of preservative, 3-8% of plant extract, 2-4% of ethanol and the balance of deionized water.

3. The anti-inflammatory and antibacterial mouthwash containing the marrubium vulgare extract as claimed in claim 1, wherein: the composite material comprises the following components in percentage by mass: marrubium vulgare extract: 0.1%, sodium azulene sulfonate: 0.05 percent of flavoring agent, 1.2 percent of preservative, 0.3 percent of plant extract, 3 percent of ethanol and the balance of deionized water.

4. The anti-inflammatory and antibacterial mouthwash containing the marrubium vulgare extract as claimed in claim 1, wherein: the flavoring agent comprises a sweetening agent and a cooling agent, and the ratio of the sweetening agent to the cooling agent is 2: 3.

5. the anti-inflammatory and antibacterial mouthwash containing the marrubium vulgare extract as claimed in claim 4, wherein the anti-inflammatory and antibacterial mouthwash is characterized in that: the sweetener is one or combination of stevioside, liquorice, disodium glycyrrhizinate, tripotassium glycyrrhizinate and trisodium glycyrrhizinate.

6. The anti-inflammatory and antibacterial mouthwash containing the marrubium vulgare extract as claimed in claim 4, wherein the anti-inflammatory and antibacterial mouthwash is characterized in that: the cooling agent is one or the combination of WS-3, WS-5, WS-10, WS-12 and WS-23.

7. The anti-inflammatory and antibacterial mouthwash containing the marrubium vulgare extract as claimed in claim 1, wherein: the preservative comprises methyl paraben and allantoin, wherein the weight ratio of the methyl paraben to the allantoin is 1: 2.

8. The anti-inflammatory and antibacterial mouthwash containing the marrubium vulgare extract as claimed in claim 1, wherein: in the step a, the water content of the dried raw materials is less than 5%.

9. The anti-inflammatory and antibacterial mouthwash containing the marrubium vulgare extract as claimed in claim 1, wherein: in the step B, the particle diameter of the raw material B is less than 60 meshes.

10. The anti-inflammatory and antibacterial mouthwash containing the marrubium vulgare extract as claimed in claim 1, wherein: in the step c, the ratio of materials to liquid before decoction is 1:10, the decoction process is to carry out high-pressure decoction for 20-30min firstly and then carry out normal-pressure decoction until the ratio of materials to liquid is 1: 5.

11. The anti-inflammatory and antibacterial mouthwash containing the marrubium vulgare extract as claimed in claim 10, wherein: the decocting pressure of the high-pressure decoction is 85-90Kpa, and the decocting temperature is 115-125 ℃.

12. The anti-inflammatory and antibacterial mouthwash containing the marrubium vulgare extract as claimed in claim 1, wherein: in the step d, the ratio of materials to liquid before decoction is 1: 6.

13. The preparation method of the oral rinse containing the marrubium vulgare extract with anti-inflammatory and antibacterial functions as claimed in any one of claims 1 to 12, wherein the oral rinse comprises the following components: the method comprises the following steps:

step three: adding the plant extract into the solution A, stirring for 5-10min by ultrasonic wave, standing and defoaming to obtain the mouthwash.