CN113440434A - Pregnant woman toothpaste containing bioactive glass and preparation method thereof - Google Patents
Pregnant woman toothpaste containing bioactive glass and preparation method thereof Download PDFInfo
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- CN113440434A CN113440434A CN202110672841.7A CN202110672841A CN113440434A CN 113440434 A CN113440434 A CN 113440434A CN 202110672841 A CN202110672841 A CN 202110672841A CN 113440434 A CN113440434 A CN 113440434A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C12/00—Powdered glass; Bead compositions
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Abstract
The invention discloses a pregnant woman toothpaste containing bioactive glass and a preparation method thereof, and the toothpaste comprises 3-25 parts of bioactive glass, 4-10 parts of hydroxyapatite, 5-20 parts of medical glycerol, 2-20 parts of hydrated silica, 3-18 parts of sorbitol, 0.5-3 parts of sodium lauryl sulfate, 1-5 parts of citric acid, 0.2-3 parts of essence, 0-2 parts of C1778910.2-2 parts, 0.5-2 parts of carbomer, 0.1-3 parts of cellulose gum, 0.2-4 parts of xylitol, 10-40 parts of polyethylene glycol-40040 parts of water and 3-10 parts of water; the toothpaste has pH of 9.3-9.8, and can neutralize acidic components in oral cavity and reduce the corrosive effect of acidic components on teeth; the hydroxyapatite is porous hydroxyapatite prepared from shell, and the bioactive glass and the hydroxyapatite are both modified by polyvinyl alcohol, so that the activity of the hydroxyapatite and the bioactive glass is improved, the bonding degree of the hydroxyapatite and the hydroxyapatite to teeth is increased, and the performance of the toothpaste is improved.
Description
Technical Field
The invention relates to toothpaste, in particular to toothpaste for pregnant women containing bioactive glass and a preparation method thereof.
Background
The toothpaste is an essential daily article in daily life, people mainly select the toothpaste from adult toothpaste and children toothpaste when purchasing the toothpaste, however, for some special people, people do not have the consciousness of selecting specific toothpaste, and one of the toothpaste is the special toothpaste for pregnant women.
During pregnancy, the levels of estrogen and progestin in pregnant women increase due to endocrine changes, and estrogen can stimulate gum swelling. Due to the influence of estrogen, gestational hormone imbalance, etc., the metabolism of the tissue is affected, thereby changing the response of the gingiva to the bacterial plaque. The gingivitis is a common oral disease of pregnant women, is unfavorable for physical and psychological health of pregnant women, is affected by 30-100% of pregnant women clinically, and is accompanied by redness, swelling, bleeding and halitosis of gum, and teeth are loosened, painful and displaced when serious.
In addition, due to the influence of hormonal changes and the increased availability of calcium during pregnancy, calcium in maternal bones and teeth is liberated into the blood and supplied to the fetus in the form of blood calcium. The pregnant woman has the problem of calcium loss, reduces the acid resistance of the teeth and is easy to have decayed teeth. Therefore, the special toothpaste used for oral health care during pregnancy plays an important role. However, the using effect of the existing toothpaste for pregnant women still cannot well meet the tooth problem of pregnant women.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide pregnant woman toothpaste containing bioactive glass and a preparation method thereof.
In order to achieve the purpose, the invention provides the following technical scheme:
the toothpaste for pregnant women containing bioactive glass is prepared from the following raw materials in parts by weight: 3-25 parts of bioactive glass, 4-10 parts of hydroxyapatite, 5-20 parts of medical glycerin, 2-20 parts of hydrated silica, 3-18 parts of sorbitol, 0.5-3 parts of sodium lauryl sulfate, 1-5 parts of citric acid, 0.2-3 parts of essence, 0.5-2 parts of C1778910.2, 0.5-2 parts of carbomer, 0.1-3 parts of cellulose gum, 0.2-4 parts of xylitol, 10-40 parts of polyethylene glycol-40010 and 3-10 parts of water;
the pH value of the toothpaste is 9.3-9.8; the hydroxyapatite is porous hydroxyapatite prepared from shells, and the bioactive glass and the hydroxyapatite are both modified by polyvinyl alcohol.
Further, the toothpaste is prepared from the following raw materials in parts by weight: 5-20 parts of bioactive glass, 5-8 parts of hydroxyapatite, 10-16 parts of medical glycerin, 5-15 parts of hydrated silica, 6-12 parts of sorbitol, 1-2 parts of sodium lauryl sulfate, 2-4 parts of citric acid, 1-2 parts of essence, 1-1.5 parts of C1778911, 1-2 parts of carbomer, 0.5-2 parts of cellulose gum, 0.5-3 parts of xylitol, 15-30 parts of polyethylene glycol-40015 and 5-8 parts of water.
Preferably, the toothpaste is prepared from the following raw materials in parts by weight: 10 parts of bioactive glass, 7 parts of hydroxyapatite, 13 parts of medical glycerin, 10 parts of hydrated silica, 9 parts of sorbitol, 1.5 parts of sodium lauryl sulfate, 3 parts of citric acid, 1.5 parts of essence, 1778911.2 parts of C, 1.5 parts of carbomer, 1.3 parts of cellulose gum, 2 parts of xylitol, 22 parts of polyethylene glycol-40022 parts of water and 7 parts of water.
Further, the modification method of the bioactive glass and the hydroxyapatite comprises the following steps: adding polyvinyl alcohol into the aqueous solution, heating and stirring for dissolving; adding bioactive glass and hydroxyapatite into an aqueous solution, performing ultrasonic dispersion, then adding a polyvinyl alcohol solution, stirring and reacting at the temperature of 80-90 ℃ for 2-4h, and performing centrifugal washing and drying to obtain a modifier of the bioactive glass and the hydroxyapatite.
Furthermore, the molar ratio of the polyvinyl alcohol to the bioactive glass or the hydroxyapatite is (3-5): 1.
Further, the preparation method of the bioactive glass comprises the following steps:
(1) uniformly stirring 20-30 parts of silicon dioxide, 40-60 parts of calcium carbonate, 45-65 parts of sodium oxide and 15-30 parts of phosphorus pentoxide, placing the mixture in a crucible, heating the mixture to 1900 ℃, and keeping the temperature for 12-16 hours to obtain a molten liquid;
(2) quenching the melt into water with the temperature less than or equal to 20 ℃, wherein the volume ratio of the melt to the water is 1:10, and the melt is dispersed into transparent particles;
(3) drying, and crushing and grading the powder in a ceramic airflow crusher.
Further, the preparation method of the hydroxyapatite comprises the following steps: adding 50-100 mesh shell powder into 5wt% diammonium hydrogen phosphate solution in a mass ratio of 1:5-10, reacting at the temperature of 250-350 ℃ for 5-10h, centrifuging, collecting precipitate, cleaning, and drying the precipitate to obtain the hydroxyapatite.
Has the advantages that: the invention provides a pregnant woman toothpaste containing bioactive glass and a preparation method thereof, and the invention has the following advantages:
1. aiming at the problem of increased acidity caused by the rising of estrogen of pregnant women, the alkalinity of the bioactive glass is improved by adjusting the raw material composition of the bioactive glass, so that the pH value of the toothpaste is increased to 9.3-9.8, the acidic components in the oral cavity are neutralized, and the corrosive effect of the acidic components on teeth is reduced;
2. aiming at the problems of increased calcium phosphorus loss ratio and increased gaps among teeth caused by the rising of estrogen of pregnant women, the invention uses polyvinyl alcohol to modify the bioactive glass and the hydroxyapatite, increases the bonding degree of the bioactive glass and the teeth and the adhesion effect of the hydroxyapatite and the teeth, and improves the effects of the bioactive glass and the hydroxyapatite and the teeth, thereby indirectly improving the problem of increased calcium phosphorus loss ratio.
Therefore, the toothpaste is suitable for being commonly used by pregnant women.
Detailed Description
The present invention is further described below with reference to specific examples, which are only exemplary and do not limit the scope of the present invention in any way. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
Example 1
The toothpaste for pregnant women containing bioactive glass is prepared from the following raw materials in parts by weight: 10 parts of bioactive glass, 7 parts of hydroxyapatite, 13 parts of medical glycerin, 10 parts of hydrated silica, 9 parts of sorbitol, 1.5 parts of sodium lauryl sulfate, 3 parts of citric acid, 1.5 parts of essence, 1778911.2 parts of C, 1.5 parts of carbomer, 1.3 parts of cellulose gum, 2 parts of xylitol, 22 parts of polyethylene glycol-40022 parts of water and 7 parts of water.
The pH value of the toothpaste is 9.3-9.8; the hydroxyapatite is porous hydroxyapatite prepared from shells, and the bioactive glass and the hydroxyapatite are both modified by polyvinyl alcohol.
The modification method of the bioactive glass and the hydroxyapatite comprises the following steps: adding polyvinyl alcohol into the aqueous solution, heating and stirring for dissolving; adding bioactive glass and hydroxyapatite into an aqueous solution, performing ultrasonic dispersion, then adding a polyvinyl alcohol solution, stirring and reacting at 85 ℃ for 3h, and performing centrifugal washing and drying to obtain a modifier of the bioactive glass and the hydroxyapatite.
The molar ratio of the polyvinyl alcohol to the bioactive glass or the hydroxyapatite is 4: 1.
The preparation method of the bioactive glass comprises the following steps:
(1) uniformly stirring 5 parts of silicon dioxide, 50 parts of calcium carbonate, 55 parts of sodium oxide and 25 parts of phosphorus pentoxide, placing the mixture in a crucible, heating the mixture to 1900 ℃, and keeping the temperature for 14 hours to obtain a molten liquid;
(2) quenching the melt into water with the temperature less than or equal to 20 ℃, wherein the volume ratio of the melt to the water is 1:10, and the melt is dispersed into transparent particles;
(3) drying, and crushing and grading the powder in a ceramic airflow crusher.
The preparation method of the hydroxyapatite comprises the following steps: adding 50-100 mesh shell powder into 5wt% diammonium hydrogen phosphate solution at a mass ratio of 1:7, reacting at 300 deg.C for 8h, centrifuging, collecting precipitate, cleaning, and oven drying the precipitate to obtain hydroxyapatite.
Example 2
The toothpaste for pregnant women containing bioactive glass is prepared from the following raw materials in parts by weight: 3 parts of bioactive glass, 4 parts of hydroxyapatite, 5 parts of medical glycerin, 2 parts of hydrated silica, 3 parts of sorbitol, 0.5 part of sodium lauryl sulfate, 1 part of citric acid, 0.2 part of essence, 1778910.2 parts of C, 0.5 part of carbomer, 0.1 part of cellulose gum, 0.2 part of xylitol, 10 parts of polyethylene glycol-40010 parts of water and 3 parts of water;
the pH value of the toothpaste is 9.3-9.8; the hydroxyapatite is porous hydroxyapatite prepared from shells, and the bioactive glass and the hydroxyapatite are both modified by polyvinyl alcohol.
The modification method of the bioactive glass and the hydroxyapatite comprises the following steps: adding polyvinyl alcohol into the aqueous solution, heating and stirring for dissolving; adding bioactive glass and hydroxyapatite into an aqueous solution, performing ultrasonic dispersion, then adding a polyvinyl alcohol solution, stirring and reacting at the temperature of 80 ℃ for 2 hours, and performing centrifugal washing and drying to obtain a modifier of the bioactive glass and the hydroxyapatite.
The molar ratio of the polyvinyl alcohol to the bioactive glass or the hydroxyapatite is 3: 1.
The preparation method of the bioactive glass comprises the following steps:
(1) uniformly stirring 20 parts of silicon dioxide, 40 parts of calcium carbonate, 45 parts of sodium oxide and 15 parts of phosphorus pentoxide, placing the mixture in a crucible, heating the mixture to 1900 ℃, and keeping the temperature for 12 hours to obtain a molten liquid;
(2) quenching the melt into water with the temperature less than or equal to 20 ℃, wherein the volume ratio of the melt to the water is 1:10, and the melt is dispersed into transparent particles;
(3) drying, and crushing and grading the powder in a ceramic airflow crusher.
The preparation method of the hydroxyapatite comprises the following steps: adding 50-100 mesh shell powder into 5wt% diammonium hydrogen phosphate solution at a mass ratio of 1:5, reacting at 250 deg.C for 5h, centrifuging, collecting precipitate, cleaning, and oven drying the precipitate to obtain hydroxyapatite.
Example 3
The toothpaste for pregnant women containing bioactive glass is prepared from the following raw materials in parts by weight: 10 parts of bioactive glass, 5 parts of hydroxyapatite, 8 parts of medical glycerol, 6 parts of hydrated silica, 5 parts of sorbitol, 2 parts of sodium lauryl sulfate, 2 parts of citric acid, 1 part of essence, 1778910.8 parts of C, 1 part of carbomer, 1.5 parts of cellulose gum, 1 part of xylitol, 15 parts of polyethylene glycol-40015 parts of water and 5 parts of water;
the pH value of the toothpaste is 9.3-9.8; the hydroxyapatite is porous hydroxyapatite prepared from shells, and the bioactive glass and the hydroxyapatite are both modified by polyvinyl alcohol.
The modification method of the bioactive glass and the hydroxyapatite comprises the following steps: adding polyvinyl alcohol into the aqueous solution, heating and stirring for dissolving; adding bioactive glass and hydroxyapatite into an aqueous solution, performing ultrasonic dispersion, then adding a polyvinyl alcohol solution, stirring and reacting at 82 ℃ for 2.5h, and performing centrifugal washing and drying to obtain a modifier of the bioactive glass and the hydroxyapatite.
The molar ratio of the polyvinyl alcohol to the bioactive glass or the hydroxyapatite is 3.5: 1.
The preparation method of the bioactive glass comprises the following steps:
(1) uniformly stirring 22 parts of silicon dioxide, 45 parts of calcium carbonate, 50 parts of sodium oxide and 20 parts of phosphorus pentoxide, placing the mixture in a crucible, heating the mixture to 1900 ℃, and keeping the temperature for 13 hours to obtain a molten liquid;
(2) quenching the melt into water with the temperature less than or equal to 20 ℃, wherein the volume ratio of the melt to the water is 1:10, and the melt is dispersed into transparent particles;
(3) drying, and crushing and grading the powder in a ceramic airflow crusher.
The preparation method of the hydroxyapatite comprises the following steps: adding 50-100 mesh shell powder into 5wt% diammonium hydrogen phosphate solution at a mass ratio of 1:6, reacting at 280 ℃ for 6h, centrifuging, collecting precipitate, cleaning, and drying the precipitate to obtain hydroxyapatite.
Example 4
The toothpaste for pregnant women containing bioactive glass is prepared from the following raw materials in parts by weight: 25 parts of bioactive glass, 10 parts of hydroxyapatite, 20 parts of medical glycerin, 20 parts of hydrated silica, 18 parts of sorbitol, 3 parts of sodium lauryl sulfate, 5 parts of citric acid, 3 parts of essence, 3 parts of C1778912, 2 parts of carbomer, 3 parts of cellulose gum, 4 parts of xylitol, 40 parts of polyethylene glycol-40040 and 10 parts of water;
the pH value of the toothpaste is 9.3-9.8; the hydroxyapatite is porous hydroxyapatite prepared from shells, and the bioactive glass and the hydroxyapatite are both modified by polyvinyl alcohol.
The modification method of the bioactive glass and the hydroxyapatite comprises the following steps: adding polyvinyl alcohol into the aqueous solution, heating and stirring for dissolving; adding bioactive glass and hydroxyapatite into an aqueous solution, performing ultrasonic dispersion, then adding a polyvinyl alcohol solution, stirring and reacting at the temperature of 90 ℃ for 4 hours, and performing centrifugal washing and drying to obtain a modifier of the bioactive glass and the hydroxyapatite.
The molar ratio of the polyvinyl alcohol to the bioactive glass or the hydroxyapatite is 5: 1.
The preparation method of the bioactive glass comprises the following steps:
(1) uniformly stirring 30 parts of silicon dioxide, 60 parts of calcium carbonate, 65 parts of sodium oxide and 30 parts of phosphorus pentoxide, placing the mixture in a crucible, heating the mixture to 1900 ℃, and keeping the temperature for 16 hours to obtain a molten liquid;
(2) quenching the melt into water with the temperature less than or equal to 20 ℃, wherein the volume ratio of the melt to the water is 1:10, and the melt is dispersed into transparent particles;
(3) drying, and crushing and grading the powder in a ceramic airflow crusher.
The preparation method of the hydroxyapatite comprises the following steps: adding 50-100 mesh shell powder into 5wt% diammonium hydrogen phosphate solution in a mass ratio of 1:10, reacting at the temperature of 250-350 ℃ for 10 hours, centrifuging, collecting precipitate, cleaning, and drying the precipitate to obtain the hydroxyapatite.
Comparative example 1
Comparative example 1 differs from example 1 in that the raw material composition of the bioactive glass is such that the pH of the final toothpaste is < 9.0.
Comparative example 2
Comparative example 2 differs from example 1 in that the bioactive glass and hydroxyapatite were not modified with polyvinyl alcohol.
120 pregnant women with oral cavity problems are divided into 6 groups, all of the pregnant women have symptoms of gingivitis pregnancy, periodontitis, gingival swelling and pain, gingival bleeding and the like with different degrees, the toothpaste is used for brushing teeth once in the morning and at night every day, and the effective control effect of the toothpaste on the symptoms is verified after 2 months of use, and the results are shown in table 1. As shown in table 1, the toothpaste prepared by the invention has good prevention and treatment effects on symptoms such as pregnancy gingivitis, periodontitis, swelling and aching of gum, gingival bleeding and the like, however, the prevention and treatment effects of the comparison documents 1 and 2 are obviously lower than those of the examples, so that the pH value of the toothpaste and the modification of the polyvinyl alcohol on the bioactive glass and the hydroxyapatite play an important role in improving the performance of the toothpaste for pregnant women, and the toothpaste can effectively keep the oral cavity clean and prevent dental diseases.
TABLE 1
Claims (7)
1. The toothpaste for pregnant women containing bioactive glass is characterized by being prepared from the following raw materials in parts by weight: 3-25 parts of bioactive glass, 4-10 parts of hydroxyapatite, 5-20 parts of medical glycerin, 2-20 parts of hydrated silica, 3-18 parts of sorbitol, 0.5-3 parts of sodium lauryl sulfate, 1-5 parts of citric acid, 0.2-3 parts of essence, 0.5-2 parts of C1778910.2, 0.5-2 parts of carbomer, 0.1-3 parts of cellulose gum, 0.2-4 parts of xylitol, 10-40 parts of polyethylene glycol-40010 and 3-10 parts of water;
the pH value of the toothpaste is 9.3-9.8; the hydroxyapatite is porous hydroxyapatite prepared from shells, and the bioactive glass and the hydroxyapatite are both modified by polyvinyl alcohol.
2. The toothpaste containing bioactive glass for pregnant women according to claim 1, wherein the toothpaste is prepared from the following raw materials in parts by weight: 5-20 parts of bioactive glass, 5-8 parts of hydroxyapatite, 10-16 parts of medical glycerin, 5-15 parts of hydrated silica, 6-12 parts of sorbitol, 1-2 parts of sodium lauryl sulfate, 2-4 parts of citric acid, 1-2 parts of essence, 1-1.5 parts of C1778911, 1-2 parts of carbomer, 0.5-2 parts of cellulose gum, 0.5-3 parts of xylitol, 15-30 parts of polyethylene glycol-40015 and 5-8 parts of water.
3. The toothpaste containing bioactive glass for pregnant women according to claim 2, wherein the toothpaste is prepared from the following raw materials in parts by weight: 10 parts of bioactive glass, 7 parts of hydroxyapatite, 13 parts of medical glycerin, 10 parts of hydrated silica, 9 parts of sorbitol, 1.5 parts of sodium lauryl sulfate, 3 parts of citric acid, 1.5 parts of essence, 1778911.2 parts of C, 1.5 parts of carbomer, 1.3 parts of cellulose gum, 2 parts of xylitol, 22 parts of polyethylene glycol-40022 parts of water and 7 parts of water.
4. The toothpaste for pregnant women containing bioactive glass as claimed in claim 1, wherein the modification method of bioactive glass and hydroxyapatite comprises the following steps: adding polyvinyl alcohol into the aqueous solution, heating and stirring for dissolving; adding bioactive glass and hydroxyapatite into an aqueous solution, performing ultrasonic dispersion, then adding a polyvinyl alcohol solution, stirring and reacting at the temperature of 80-90 ℃ for 2-4h, and performing centrifugal washing and drying to obtain a modifier of the bioactive glass and the hydroxyapatite.
5. The toothpaste for pregnant women containing bioactive glass as claimed in claim 4, wherein the molar ratio of polyvinyl alcohol to bioactive glass or hydroxyapatite is (3-5): 1.
6. The toothpaste for pregnant women containing bioactive glass as claimed in claim 1, wherein the preparation method of the bioactive glass comprises the following steps:
(1) uniformly stirring 20-30 parts of silicon dioxide, 40-60 parts of calcium carbonate, 45-65 parts of sodium oxide and 15-30 parts of phosphorus pentoxide, placing the mixture in a crucible, heating the mixture to 1900 ℃, and keeping the temperature for 12-16 hours to obtain a molten liquid;
(2) quenching the melt into water with the temperature less than or equal to 20 ℃, wherein the volume ratio of the melt to the water is 1:10, and the melt is dispersed into transparent particles;
(3) drying, and crushing and grading the powder in a ceramic airflow crusher.
7. The pregnant woman toothpaste containing bioactive glass as claimed in claim 1, wherein the preparation method of the hydroxyapatite comprises the following steps: adding 50-100 mesh shell powder into 5wt% diammonium hydrogen phosphate solution in a mass ratio of 1:5-10, reacting at the temperature of 250-350 ℃ for 5-10h, centrifuging, collecting precipitate, cleaning, and drying the precipitate to obtain the hydroxyapatite.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114533611A (en) * | 2022-02-16 | 2022-05-27 | 重庆登康口腔护理用品股份有限公司 | Composition capable of enhancing dentin sensitivity resistance effect of bioactive material and preparation method and application thereof |
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| 韩海生等, 中国纺织出版社有限公司 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114533611A (en) * | 2022-02-16 | 2022-05-27 | 重庆登康口腔护理用品股份有限公司 | Composition capable of enhancing dentin sensitivity resistance effect of bioactive material and preparation method and application thereof |
| CN114533611B (en) * | 2022-02-16 | 2023-08-29 | 重庆登康口腔护理用品股份有限公司 | Composition capable of enhancing dentin sensitivity resisting effect of bioactive material and preparation method and application thereof |
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