CN108125806A - Toothpaste containing bioactivity glass - Google Patents
Toothpaste containing bioactivity glass Download PDFInfo
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- CN108125806A CN108125806A CN201810068826.XA CN201810068826A CN108125806A CN 108125806 A CN108125806 A CN 108125806A CN 201810068826 A CN201810068826 A CN 201810068826A CN 108125806 A CN108125806 A CN 108125806A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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Abstract
The present invention provides a kind of toothpaste containing bioactivity glass.Preparation method is as follows:Medical glycerine and Acritamer 940 are sufficiently stirred, stood;Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol 400, bay alcohol sulfuric ester receive, natural essence, micro-nano bioactivity glass, nano-bioactive glass, nanometer hydroxyapatite, pure water, citric acid and C177891, be sufficiently stirred to obtain the final product.The toothpaste of the present invention improves the enclosed of dentinal tubule with nanometer, micro-nano bioactivity glass, hydroxyapatite variable grain size mixture, achievees the effect that alleviate gingival atrophy, slows down bleeding gums, slow and prevention tooth mobility, prevention periodontosis, maintenance enamel, reduces odonthemodia, firm tooth and promote dental growth.
Description
Technical field
The present invention relates to biological nanos and micro-nano material field, and in particular to the toothpaste containing bioactivity glass.
Background technology
The diseases such as sensitivity of tooth, pain, bleeding mainly obstruct stimulation by repairing dental enamel and closure dentinal tubule
Source, which requires enamel reparation material extremely close to enamel composition, and blocking dentinal tubule just needs
As high as possible raising sealing ratiod and length is blocked to reach.Bioactivity glass, hydroxyapatite have good reparation and envelope
Stifled effect, but the porosity of everyone constitution and dentinal tubule and density are inconsistent, so relative to bioactivity
Glass, hydroxyapatite and the rational proportion of the dental component degree of approximation and granular size are with regard to extremely important.
Invention content
Technical problems to be solved:The object of the present invention is to provide the toothpaste containing bioactivity glass, with nanometer, micro-
Nano-bioactive glass, hydroxyapatite variable grain size mixture come reach alleviate gingival atrophy, slow down bleeding gums,
Slow and prevention tooth mobility, maintenance enamel, reduces odonthemodia, firm tooth and the effect for promoting dental growth at prevention periodontosis
Fruit.
Technical solution:Toothpaste containing bioactivity glass, in parts by weight including following component:0.05-1 parts of nanometers
Bioactivity glass, 0.7-35 parts of micro-nano bioactivity glass, 0.1-5 parts of nanometer hydroxyapatites.
It is further preferred that the toothpaste containing bioactivity glass, in parts by weight including following component:
0.05-1 parts of nano-bioactive glass, 0.1-5 parts of grain sizes are 0.5-1 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes are
The micro-nano bioactivity glass of 1-5 μm of grade, 0.1-5 parts of grain sizes are 5-15 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes are
15-30 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes are 30-55 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes
For 55-75 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes be 75-90 μm of micro-nano bioactivity glass, 0.1-5 parts receive
Rice hydroxyapatite, 25-50 parts of medical glycerines, 13-20 parts of sorbierites, 0.01-0.3 parts of medical polyethylene glycol-400,5-50 parts
Hydrated silica, 0.01-0.55 part Acritamer 940,0.02-1.2 parts of xylitols, 0.05-2.0 parts of natural essences, 0.05-3.5 parts
Bay alcohol sulfuric ester is received, 0.01-0.55 parts of sodium cellulosates, 0.05-3.0 parts of citric acids, 0.5-10 parts of pure water, 0.5-1 parts
C177891 。
It is further preferred that the toothpaste containing bioactivity glass, in parts by weight including following component:
0.05-1 parts of nano-bioactive glass, 0.1-5 parts of grain sizes are 0.5-1 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes are
The micro-nano bioactivity glass of 1-5 μm of grade, 0.1-5 parts of grain sizes are 5-15 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes are
15-30 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes are 30-55 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes
For 55-75 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes be 75-90 μm of micro-nano bioactivity glass, 0.1-5 parts receive
Rice hydroxyapatite, 30-35 parts of D-sorbites, 18-20 parts of medical glycerines, 0.15-0.2 parts of medical polyethylene glycol-400,28-29
Part hydrated silica, 0.6-0.7 parts of konjac glucomannans, 0.5-0.6 parts of mucopolysaccharides, 0.5-0.55 parts of natural essences, 0.28-0.29 portions of soybean
Protein isolate, 0.35-0.36 part casein, 0.2-0.4 parts of Moringa extracts, 0.3-0.4 parts of butylated hydroxy anisoles, 10-11
Part pure water, 0.5-0.6 parts of C177891.
It is further preferred that the preparation method of the micro-nano bioactivity glass is:
(1)1-10 parts of 35-55 parts of quartz sand, 30-50 parts of calcium carbonate, 30-50 parts of sodium carbonate and phosphorus pentoxide are stirred evenly,
It is placed in pincers pot and is warming up to 1900 DEG C, 20 hours, obtain melt;
(2)Melt is quenched in the water of temperature≤20 DEG C, the volume ratio of melt and water is 1:10, it quenches and dissipates into transparent grain;
(3)Drying smashes classification powder in ceramic air-flow disintegrating machine.
It is further preferred that the Moringa extract uses hot water ultrasonic extraction, will be crushed after 20 parts of freeze-dryings
Moringa, with 400-500ml distilled water at 80-90 DEG C of temperature ultrasonic extraction 14 hours, dry extract.
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite, including following step
Suddenly:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, 0.7-35 parts of micro-nano bioactivity glass, nano-bioactive glass, nanometer hydroxyapatite, pure
Water, citric acid and C177891, are sufficiently stirred to obtain the final product.
Advantageous effect:The toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite of the present invention, with receiving
Rice, micro-nano bioactivity glass, hydroxyapatite variable grain size mixture come reach alleviate gingival atrophy, slow down gum
Bleeding, prevention periodontosis, maintenance enamel, reduces odonthemodia, firm tooth and promotes dental growth slow and prevention tooth mobility
Effect.The micro-nano various combination from nanometer materials to 1-90, can bring it is best with Dental Erosion effect, also can be significantly
The enclosed of dentinal tubule is improved, even up to very enclosed, closure length also reach unprecedented height.
Specific embodiment
Embodiment 1
Toothpaste containing bioactivity glass, including following component:0.1 part of nano-bioactive glass, 0.5 part of grain size are 0.5-
1 μm of micro-nano bioactivity glass, 0.5 grain size are a part 1-5 μm of micro-nano bioactivity glass, 0.35 part of grain size is 5-15 μm
Micro-nano bioactivity glass, 0.25 part of grain size are 15-30 μm of micro-nano bioactivity glass, 0.15 part of grain size is 30-55 μm
Micro-nano bioactivity glass, 0.5 part of grain size are 55-75 μm of micro-nano bioactivity glass, 0.5 part of grain size is 75-90 μm micro-
Nano-bioactive glass, 1 part of nanometer hydroxyapatite, 30 parts of medical glycerines, 18 parts of sorbierites, 0.16 part of medical poly- second two
Alcohol -400,35.9 parts of hydrated silicas, 0.55 part of Acritamer 940,0.5 part of xylitol, 0.5 part of natural essence, 0.28 portion of bay
Alcohol sulfuric ester is received, 0.35 part of sodium cellulosate, 1 part of citric acid, 8.41 parts of pure water, 0.5 part of C177891.
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, grain size are 0.5-1 μm of micro-nano bioactivity glass, grain size be 1-5 μm of micro-nano bioactivity glass,
Grain size is 5-15 μm of micro-nano bioactivity glass, grain size is 15-30 μm of micro-nano bioactivity glass, grain size is 30-55 μm
Micro-nano bioactivity glass, grain size are 55-75 μm of micro-nano bioactivity glass, grain size is that 75-90 μm of micro-nano biology is living
Property glass, nano-bioactive glass, nanometer hydroxyapatite, pure water, citric acid and C177891, are sufficiently stirred to obtain the final product.
The present embodiment is 67.32% to the permeability of Dental Erosion and dentinal tubule, general to sensitivity of tooth degree of slowing,
And it is general to the periodontosis effect such as gingival atrophy, dental hemorrhage, the sophistication of toothpaste is general, and foaming abundancy degree is general.
Embodiment 2
Toothpaste containing bioactivity glass, including following component:0.3 part of nano-bioactive glass, 2.5 parts of grain sizes are 0.5-
1 μm of micro-nano bioactivity glass, 1.5 parts of grain sizes are 1-5 μm of micro-nano bioactivity glass, 0.75 part of grain size is 5-15 μm micro-
Nano-bioactive glass, 0.75 part of grain size are 15-30 μm of micro-nano bioactivity glass, 0.35 part of grain size is 30-55 μm micro-
Nano-bioactive glass, 0.35 part of grain size are 55-75 μm of micro-nano bioactivity glass, 0.15 part of grain size is 75-90 μm micro-
Nano-bioactive glass, 1.3 parts of nanometer hydroxyapatites, 32.5 parts of medical glycerines, 18 parts of sorbierites, 0.16 part of medical poly- second
Glycol -400,28.11 parts of hydrated silicas, 0.65 part of Acritamer 940,0.5 part of xylitol, 0.5 part of natural essence, 0.28 part month
Cinnamic alcohol sulfuric ester is received, 0.35 part of sodium cellulosate, 0.5 part of citric acid, 10 parts of pure water, 0.5 part of C177891.
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, grain size are 0.5-1 μm of micro-nano bioactivity glass, grain size be 1-5 μm of micro-nano bioactivity glass,
Grain size is 5-15 μm of micro-nano bioactivity glass, grain size is 15-30 μm of micro-nano bioactivity glass, grain size is 30-55 μm
Micro-nano bioactivity glass, grain size are 55-75 μm of micro-nano bioactivity glass, grain size is that 75-90 μm of micro-nano biology is living
Property glass, nano-bioactive glass, nanometer hydroxyapatite, pure water, citric acid and C177891, are sufficiently stirred to obtain the final product.
The present embodiment is 92.07% to the permeability of Dental Erosion and dentinal tubule, preferable to sensitivity of tooth degree of slowing,
And it is relatively good to the periodontosis effect such as gingival atrophy, dental hemorrhage, the sophistication of toothpaste is moderate, and foaming abundancy degree is moderate.
1. enclosed experiment:
A. it is fresh pull out without dental caries third molar 20, occlusal surface enamel and root face cementum are removed, with low speed cutting machine by tooth
Body is at 1.00 mm, vertical tooth long axile is cut into the tooth piece of 1.00 mm thickness, pays attention to avoiding pulp horn, be stored on enamelo-cemental junction
0.15M cacodylates(CAB)In buffer solution;
B. 40 dentine slice surfaces are taken into 40 teeth therein at random respectively with 500 mesh and the SiC coated abrasive workings of 900 mesh
Piece, which is put into 6.5 parts of citric acids, impregnates 3min, and all tooth piece ultrasounds are swung and are washed, and drying is spare;
C. it is divided to A/B two groups by the sample of collection using the method being grouped at random, every group 20, A groups use the present embodiment toothpaste, B
Group other phosphoric acid calcium composition toothpaste on the market, the processing daily of every group of sample twice, every time with electronic toothbrush two minutes,
It is handled 1 time every for 24 hours, is put into artificial saliva and preserves after having handled, continue 15 days;
D. each processing group dentine piece that takes that treated, dry, metal spraying observe the table of dentinal tubule under scanning electron microscope
Face form and profile morphology.
EIS detections are carried out to above-mentioned two groups of dentine pieces of A/B, 1 times a week, dentine disk split intracavitary is placed in, worked
Electrode is graphite electrode, reference electrode and be respectively that A parts/A parts Cl electrodes and platinum electrode, EIS testing results are shown to electrode:This
Embodiment toothpaste can reach 2.7-2.8 or so to dentine disk electrochemistry disk impedance value peak, significantly larger than now on the market
Toothpaste is to dentine disk electrochemistry disk impedance value 2.3-2.4, and also longer, increasing degree bigger in resistance rise time efficiency, relatively
Advantage can promote 20% or so.Its sealing ratiod and depth, higher than control group toothpaste now on the market.
2. remineralization is tested
A. it is fresh pull out without dental caries premolar teeth 20, the tooth piece of 1.00 mm thickness is made, pays attention to avoiding pulp horn, is stored in 0.1M bis-
Methylarsenate(CAB)It is spare in buffer solution;
B. 15 samples are immersed into 30ml calcium containing 2.0mmol/L and phosphorus respectively with 500 mesh and the SiC coated abrasive workings of 900 mesh
Acid group, 50 mmol/L acetic acid acid solution in(PH 5.0), 72 h of demineralization under the conditions of 37 DEG C forms artificial dentine
Dental caries after taking-up, mix the sample with that distilled water flushing is clean, spontaneously dries, it is seen that its surface is in the change of chalk color;
C. all samples are divided into 3 groups using the method being grouped at random, every group of 5 samples:
1. group is uses the present embodiment toothpaste
2. group is using other phosphoric acid calcium on the market(Bioactivity glass)Toothpaste
3. group is uses distilled water
Every group of sample processing 2 times daily, every time with electronic toothbrush 3 minutes;PH is recycled:Sample is put into daily in demineralization liquid
4h, 20h in remineralization liquid, continues 20 days.
D.(1)Micro-hardness testing
Each processing group sample measures the microhardness value of dentine respectively before demineralization, after demineralization, after remineralization, compares each group
The firmness change of sample, the mineral loss or acquisition amount and calcium-phosphorus ratio of indirect quantification measure sample.
。
(2)Laser confocal microscope
Mix the sample with 0.1 part of rhodamine B fluorescent dyeing 1 hour, CLSM shooting images analyze each group demineralization depth(H)'s
Difference damages fluorescence Class area estimation Mineral change situation according to dental caries.
As a result show that 1. group remineralization effect is significantly better than 2. group, remineralization promotes amplitude between 20-35%.
Embodiment 3
Toothpaste containing bioactivity glass, including following component:0.5 part of nano-bioactive glass, 2 parts of grain sizes are 0.5-1 μ
The micro-nano bioactivity glass of m, 2 parts of grain sizes are 1-5 μm of micro-nano bioactivity glass, 1.25 parts of grain sizes are 5-15 μm micro-nano
Bioactivity glass, 1.55 parts of grain sizes are 15-30 μm of micro-nano bioactivity glass, 1 part of grain size is 30-55 μm of micro-nano biology
Activity glass, 1 part of grain size are 55-75 μm of micro-nano bioactivity glass, 1 part of grain size is 75-90 μm of micro-nano bioactivity glass
Glass, 2.2 parts of nanometer hydroxyapatites, 28 parts of medical glycerines, 16 parts of sorbierites, 0.1 part of medical polyethylene glycol-400,26.5 hydrations
Silica part, 1 part of Acritamer 940,0.3 part of xylitol, 0.3 part of natural essence, 0.2 part of bay alcohol sulfuric ester are received, 0.2 part of fiber
Plain sodium, 0.2 part of citric acid, 14.6 parts of pure water, 0.1 part of C177891.
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, grain size are 0.5-1 μm of micro-nano bioactivity glass, grain size be 1-5 μm of micro-nano bioactivity glass,
Grain size is 5-15 μm of micro-nano bioactivity glass, grain size is 15-30 μm of micro-nano bioactivity glass, grain size is 30-55 μm
Micro-nano bioactivity glass, grain size are 55-75 μm of micro-nano bioactivity glass, grain size is that 75-90 μm of micro-nano biology is living
Property glass, nano-bioactive glass, nanometer hydroxyapatite, pure water, citric acid and C177891, are sufficiently stirred to obtain the final product.
The present embodiment is 89.97% to the permeability of Dental Erosion and dentinal tubule, good to sensitivity of tooth degree of slowing, and
Good to the periodontosis such as gingival atrophy, dental hemorrhage effect, the sophistication of toothpaste is general, and foaming abundancy degree is general.
Embodiment 4
Toothpaste containing bioactivity glass, in parts by weight including following component:0.05 part of nano-bioactive glass, 0.1
Part grain size is 0.5-1 μm of micro-nano bioactivity glass, 0.1 part of grain size be the micro-nano bioactivity glass of 1-5 μm of grade, 0.1 part
Grain size is 5-15 μm of micro-nano bioactivity glass, 0.1 part of grain size is 15-30 μm of micro-nano bioactivity glass, 0.1 part of grain size
For 30-55 μm of micro-nano bioactivity glass, 0.1 part of grain size be 55-75 μm of micro-nano bioactivity glass, 0.1 part of grain size is
75-90 μm of micro-nano bioactivity glass, 0.1 part of nanometer hydroxyapatite, 25 parts of medical glycerines, 13 parts of sorbierites, 0.01 part
Medical polyethylene glycol-400,5 parts of hydrated silicas, 0.01 part of Acritamer 940,0.02 part of xylitol, 0.05 part of natural essence, 0.05
Part bay alcohol sulfuric ester is received, 0.01 part of sodium cellulosate, 0.05 part of citric acid, 0.5 part of pure water, 0.5 part of C177891.
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, grain size are 0.5-1 μm of micro-nano bioactivity glass, grain size be 1-5 μm of micro-nano bioactivity glass,
Grain size is 5-15 μm of micro-nano bioactivity glass, grain size is 15-30 μm of micro-nano bioactivity glass, grain size is 30-55 μm
Micro-nano bioactivity glass, grain size are 55-75 μm of micro-nano bioactivity glass, grain size is that 75-90 μm of micro-nano biology is living
Property glass, nano-bioactive glass, nanometer hydroxyapatite, pure water, citric acid and C177891, are sufficiently stirred to obtain the final product.
The present embodiment is 73.45% to the permeability of Dental Erosion and dentinal tubule, general to sensitivity of tooth degree of slowing,
And it is general to the periodontosis effect such as gingival atrophy, dental hemorrhage, the sophistication of toothpaste is general, and foaming abundancy degree is general.
Embodiment 5
Toothpaste containing bioactivity glass, in parts by weight including following component:1 part of nano-bioactive glass, 5 parts of grain sizes
For 0.5-1 μm of micro-nano bioactivity glass, 5 parts of grain sizes be the micro-nano bioactivity glass of 1-5 μm of grade, 5 parts of grain sizes are 5-15 μ
The micro-nano bioactivity glass of m, 5 parts of grain sizes are 15-30 μm of micro-nano bioactivity glass, 5 parts of grain sizes are 30-55 μm micro-nano
Bioactivity glass, 5 parts of grain sizes are 55-75 μm of micro-nano bioactivity glass, 5 parts of grain sizes are that 75-90 μm of micro-nano biology is living
Property glass, 5 parts of nanometer hydroxyapatites, 50 parts of medical glycerines, 20 parts of sorbierites, 0.3 part of medical polyethylene glycol-400,50 parts of water
Conjunction silica, 0.55 part of Acritamer 940,1.2 parts of xylitols, 2.0 parts of natural essences, 3.5 parts of bay alcohol sulfuric esters are received, 0.55 part
Sodium cellulosate, 3.0 parts of citric acids, 10 parts of pure water, 1 part of C177891.
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, grain size are 0.5-1 μm of micro-nano bioactivity glass, grain size be 1-5 μm of micro-nano bioactivity glass,
Grain size is 5-15 μm of micro-nano bioactivity glass, grain size is 15-30 μm of micro-nano bioactivity glass, grain size is 30-55 μm
Micro-nano bioactivity glass, grain size are 55-75 μm of micro-nano bioactivity glass, grain size is that 75-90 μm of micro-nano biology is living
Property glass, nano-bioactive glass, nanometer hydroxyapatite, pure water, citric acid and C177891, are sufficiently stirred to obtain the final product.
The present embodiment is 78.96% to the permeability of Dental Erosion and dentinal tubule, general to sensitivity of tooth degree of slowing,
And it is general to the periodontosis effect such as gingival atrophy, dental hemorrhage, the sophistication of toothpaste is general, and foaming abundancy degree is general.
Embodiment 6
Toothpaste containing bioactivity glass, including following component:0.3 part of nano-bioactive glass, 2.5 parts of grain sizes are
0.5-1 μm of micro-nano bioactivity glass, 1.5 parts of grain sizes are 1-5 μm of micro-nano bioactivity glass, 0.75 part of grain size is 5-15
μm micro-nano bioactivity glass, 0.75 part of grain size are 15-30 μm of micro-nano bioactivity glass, 0.35 part of 30-55 μm of micro-nano
Rice bioactivity glass, 0.35 part of grain size are 55-75 μm of micro-nano bioactivity glass, 0.15 part of grain size is 75-90 μm of micro-nano
Rice bioactivity glass, 1.3 parts of nanometer hydroxyapatites, 32.5 parts of D-sorbites, 18 parts of medical glycerines, 0.16 part of medical poly- second
Glycol -400,28.11 parts of hydrated silicas, 0.65 part of konjac glucomannan, 0.5 part of mucopolysaccharide, 0.5 part of natural essence, 0.28 portion of soybean
Protein isolate, 0.35 part of casein, 0.2 part of Moringa extract, 0.3 part of butylated hydroxy anisole, 10.2 parts of pure water, 0.5 part
C177891。
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:Medical glycerine and konjac glucomannan are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add D-sorbite, casein, mucopolysaccharide, hydrated silica, medical polyethylene glycol-400, soybean separation protein
In vain, natural essence, grain size are 0.5-1 μm of micro-nano bioactivity glass, grain size is 1-5 μm of micro-nano bioactivity glass, grain
Diameter is 5-15 μm of micro-nano bioactivity glass, grain size is 15-30 μm of micro-nano bioactivity glass, grain size is 30-55 μm micro-
Nano-bioactive glass, grain size are 55-75 μm of micro-nano bioactivity glass, grain size is 75-90 μm of micro-nano bioactivity
Glass, nano-bioactive glass, nanometer hydroxyapatite, Moringa extract, pure water, butylated hydroxy anisole and
C177891 is sufficiently stirred to obtain the final product.
The present embodiment is 90.12% to the permeability of Dental Erosion and dentinal tubule, good to sensitivity of tooth degree of slowing, and
Good to the periodontosis such as gingival atrophy, dental hemorrhage effect, the sophistication of toothpaste is preferable, and foaming abundancy degree is general.
Embodiment 7
Toothpaste containing bioactivity glass, including following component:0.3 part of nano-bioactive glass, 2.5 parts of grain sizes are 0.5-
1 μm of micro-nano bioactivity glass, 1.5 parts of grain sizes are 1-5 μm of micro-nano bioactivity glass, 0.75 part of grain size is 5-15 μm micro-
Nano-bioactive glass, 0.75 part of grain size are 15-30 μm of micro-nano bioactivity glass, 0.35 part of grain size is 30-55 μm micro-
Nano-bioactive glass, 0.35 part of grain size are 55-75 μm of micro-nano bioactivity glass, 0.15 part of grain size is 75-90 μm micro-
Nano-bioactive glass, 1.3 parts of nanometer hydroxyapatites, 30 parts of D-sorbites, 2.5 parts of glycol glucosides, 18 parts of malt
Oligomeric sugar alcohol, 0.16 part of stearoyl lactate, 28.11 parts of hydrated silicas, 0.65 part of Acritamer 940,0.5 part of shea butter,
0.5 part of natural essence, 0.28 part of soybean lecithin, 0.4 part of Moringa extract, 0.35 part of beeswax, 0.5 part of citric acid, 10 parts it is pure
Water purification, 0.5 part of C177891.
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:D-sorbite and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add malto-oligosaccharide alcohol, glycol glucoside, beeswax, shea butter, hydrated silica, stearoyl lactylates
Sodium, soybean lecithin, natural essence, grain size are 0.5-1 μm of micro-nano bioactivity glass, grain size is 1-5 μm of micro-nano biology
Activity glass, grain size are 5-15 μm of micro-nano bioactivity glass, grain size is 15-30 μm of micro-nano bioactivity glass, grain size
For 30-55 μm of micro-nano bioactivity glass, grain size be 55-75 μm of micro-nano bioactivity glass, grain size is 75-90 μm of micro-nano
Rice bioactivity glass, nano-bioactive glass, nanometer hydroxyapatite, Moringa extract, pure water, citric acid and
C177891 is sufficiently stirred to obtain the final product.
The present embodiment is 90.83% to the permeability of Dental Erosion and dentinal tubule, preferable to sensitivity of tooth degree of slowing,
And it is relatively good to the periodontosis effect such as gingival atrophy, dental hemorrhage, the sophistication of toothpaste is general, and foaming abundancy degree is moderate.
Embodiment 8
Toothpaste containing bioactivity glass, including following component:1-2 parts of phosphorus calcium silicates sodium, 0.5-1 parts of phlogopite crystallite, 0.1
Part nano-bioactive glass, 0.5 part of grain size are 0.5-1 μm of micro-nano bioactivity glass, 0.5 grain size is a part 1-5 μm of micro-nano
Rice bioactivity glass, 0.35 part of grain size are 5-15 μm of micro-nano bioactivity glass, 0.25 part of grain size is 15-30 μm micro-nano
Bioactivity glass, 0.15 part of grain size are 30-55 μm of micro-nano bioactivity glass, 0.5 part of grain size is 55-75 μm of micro-nano life
Object activity glass, 0.5 part of grain size are 75-90 μm of micro-nano bioactivity glass, 1 part of nanometer hydroxyapatite, 30 parts it is medical sweet
Oil, 18 parts of sorbierites, 0.16 part of medical polyethylene glycol-400,35.9 parts of hydrated silicas, 0.55 part of Acritamer 940,0.5 part of wood
Sugar alcohol, 0.5 part of natural essence, 0.28 part of bay alcohol sulfuric ester are received, 0.35 part of sodium cellulosate, 1 part of citric acid, 8.41 parts it is pure
Water, 0.5 part of C177891.
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, phosphorus calcium silicates sodium, machinable bioactivity glass, grain size are 0.5-1 μm of micro-nano bioactivity glass,
Grain size is 1-5 μm of micro-nano bioactivity glass, grain size is 5-15 μm of micro-nano bioactivity glass, grain size is 15-30 μm micro-
Nano-bioactive glass, grain size are 30-55 μm of micro-nano bioactivity glass, grain size is 55-75 μm of micro-nano bioactivity
Glass, grain size for 75-90 μm of micro-nano bioactivity glass, nano-bioactive glass, nanometer hydroxyapatite, pure water,
Citric acid and C177891, are sufficiently stirred to obtain the final product.
The present embodiment is 67.32% to the permeability of Dental Erosion and dentinal tubule, general to sensitivity of tooth degree of slowing,
And it is general to the periodontosis effect such as gingival atrophy, dental hemorrhage, the sophistication of toothpaste is general, and foaming abundancy degree is general.
Embodiment 9
Toothpaste containing bioactivity glass, including following component:1 part of fluorophologopite powder, 0.3 part of nano-bioactive glass,
2.5 parts of grain sizes are 0.5-1 μm of micro-nano bioactivity glass, 1.5 parts of grain sizes are 1-5 μm of micro-nano bioactivity glass, 0.75
Part grain size is 5-15 μm of micro-nano bioactivity glass, 0.75 part of grain size be 15-30 μm of micro-nano bioactivity glass, 0.35 part
Grain size is 30-55 μm of micro-nano bioactivity glass, 0.35 part of grain size be 55-75 μm of micro-nano bioactivity glass, 0.15 part
Grain size is 75-90 μm of micro-nano bioactivity glass, 1.3 parts of nanometer hydroxyapatites, 32.5 parts of medical glycerines, 18 portions of sorbs
Alcohol, 0.16 part of medical polyethylene glycol-400,28.11 parts of hydrated silicas, 0.65 part of Acritamer 940,0.5 part of xylitol, 0.5 part
Natural essence, 0.28 part of bay alcohol sulfuric ester are received, 0.35 part of sodium cellulosate, 0.5 part of citric acid, 10 parts of pure water, 0.5 part
C177891。
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, fluorophologopite powder, grain size are 0.5-1 μm of micro-nano bioactivity glass, grain size is 1-5 μm of micro-nano life
Object activity glass, grain size are 5-15 μm of micro-nano bioactivity glass, grain size is 15-30 μm of micro-nano bioactivity glass, grain
Diameter is 30-55 μm of micro-nano bioactivity glass, grain size is 55-75 μm of micro-nano bioactivity glass, grain size is 75-90 μm micro-
Nano-bioactive glass, nano-bioactive glass, nanometer hydroxyapatite, pure water, citric acid and C177891, fully
It stirs to obtain the final product.
The present embodiment is 92.01% to the permeability of Dental Erosion and dentinal tubule, preferable to sensitivity of tooth degree of slowing,
And it is relatively good to the periodontosis effect such as gingival atrophy, dental hemorrhage, the sophistication of toothpaste is moderate, and foaming abundancy degree is moderate.
Comparative example 1
Toothpaste containing bioactivity glass, including following component:0.3 part of nano-bioactive glass, 4.75 parts of grain sizes are 5-
15 μm of micro-nano bioactivity glass, 0.75 part of grain size are 15-30 μm of micro-nano bioactivity glass, 0.35 part of grain size is 30-
55 μm of micro-nano bioactivity glass, 0.35 part of grain size are 55-75 μm of micro-nano bioactivity glass, 0.15 part of grain size is 75-
90 μm of micro-nano bioactivity glass, 1.3 parts of nanometer hydroxyapatites, 32.5 parts of medical glycerines, 18 parts of sorbierites, 0.16 part of doctor
With polyethylene glycol-400,28.11 parts of hydrated silicas, 0.65 part of Acritamer 940,0.5 part of xylitol, 0.5 part of natural essence,
0.28 part of bay alcohol sulfuric ester is received, 0.35 part of sodium cellulosate, 0.5 part of citric acid, 10 parts of pure water, 0.5 part of C177891.
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, 5-15 μm of grain size are micro-nano bioactivity glass, 15-30 μm of grain size be micro-nano bioactivity glass,
30-55 μm of grain size is micro-nano bioactivity glass, 55-75 μm of grain size is micro-nano bioactivity glass, 75-90 μm of grain size is
Micro-nano bioactivity glass, nano-bioactive glass, nanometer hydroxyapatite, pure water, citric acid and C177891, fill
Divide and stir to obtain the final product.
The present embodiment is 82.78% to the permeability of Dental Erosion and dentinal tubule, general to sensitivity of tooth degree of slowing,
General to the periodontosis effect such as gingival atrophy, dental hemorrhage, the sophistication of toothpaste is moderate, and foaming abundancy degree is moderate.
Comparative example 2
Toothpaste containing bioactivity glass, including following component:0.3 part of nano-bioactive glass, 4 parts of grain sizes are 0.5-1 μ
The micro-nano bioactivity glass of m, 1.5 parts of grain sizes are 1-5 μm of micro-nano bioactivity glass, 0.35 part of grain size is 30-55 μm micro-
Nano-bioactive glass, 0.35 part of grain size are 55-75 μm of micro-nano bioactivity glass, 0.15 part of grain size is 75-90 μm micro-
Nano-bioactive glass, 1.3 parts of nanometer hydroxyapatites, 32.5 parts of medical glycerines, 18 parts of sorbierites, 0.16 part of medical poly- second
Glycol -400,28.11 parts of hydrated silicas, 0.65 part of Acritamer 940,0.5 part of xylitol, 0.5 part of natural essence, 0.28 part month
Cinnamic alcohol sulfuric ester is received, 0.35 part of sodium cellulosate, 0.5 part of citric acid, 10 parts of pure water, 0.5 part of C177891.
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, grain size are 0.5-1 μm of micro-nano bioactivity glass, grain size be 1-5 μm of micro-nano bioactivity glass,
Grain size is 30-55 μm of micro-nano bioactivity glass, grain size is 55-75 μm of micro-nano bioactivity glass, grain size is 75-90 μm
Micro-nano bioactivity glass, nano-bioactive glass, nanometer hydroxyapatite, pure water, citric acid and C177891, fill
Divide and stir to obtain the final product.
The present embodiment is 84.57% to the permeability of Dental Erosion and dentinal tubule, preferable to sensitivity of tooth degree of slowing,
And it is general to the periodontosis effect such as gingival atrophy, dental hemorrhage, the sophistication of toothpaste is moderate, and foaming abundancy degree is moderate.
Comparative example 3
Toothpaste containing bioactivity glass, including following component:0.3 part of nano-bioactive glass, 2.5 parts of grain sizes are 0.5-
1 μm of micro-nano bioactivity glass, 2.35 parts of grain sizes are 1-5 μm of micro-nano bioactivity glass, 0.75 part of grain size is 5-15 μm
Micro-nano bioactivity glass, 0.75 part of grain size are 15-30 μm of micro-nano bioactivity glass, 1.3 parts of nanometer hydroxyapatites,
32.5 parts of medical glycerines, 18 parts of sorbierites, 0.16 part of medical polyethylene glycol-400,28.11 parts of hydrated silicas, 0.65 part of carbomer
940th, 0.5 part of xylitol, 0.5 part of natural essence, 0.28 part of bay alcohol sulfuric ester receive, 0.35 part of sodium cellulosate, 0.5 portion of lemon
Acid, 10 parts of pure water, 0.5 part of C177891.
The preparation method of the above-mentioned toothpaste containing micro-nano bioactivity glass and nanometer hydroxyapatite is:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, grain size are 0.5-1 μm of micro-nano bioactivity glass, grain size be 1-5 μm of micro-nano bioactivity glass,
Grain size is 5-15 μm of micro-nano bioactivity glass, grain size is 15-30 μm of micro-nano bioactivity glass, nano-bioactive glass
Glass, nanometer hydroxyapatite, pure water, citric acid and C177891, are sufficiently stirred to obtain the final product.
The present embodiment is 85.64% to the permeability of Dental Erosion and dentinal tubule, general to sensitivity of tooth degree of slowing,
And it is relatively good to the periodontosis effect such as gingival atrophy, dental hemorrhage, the sophistication of toothpaste is general, and foaming abundancy degree is moderate.
Claims (6)
1. the toothpaste containing bioactivity glass, which is characterized in that in parts by weight including following component:0.05-1 parts of nanometer lifes
Object activity glass, 0.7-35 parts of micro-nano bioactivity glass, 0.1-5 parts of nanometer hydroxyapatites.
2. the toothpaste according to claim 1 containing bioactivity glass, it is characterised in that:Include in parts by weight following
Ingredient:0.05-1 parts of nano-bioactive glass, 0.1-5 parts of grain sizes are 0.5-1 μm of micro-nano bioactivity glass, 0.1-5 parts
Grain size is the micro-nano bioactivity glass of 1-5 μm of grade, 0.1-5 parts of grain sizes be 5-15 μm of micro-nano bioactivity glass, 0.1-5 parts
Grain size is 15-30 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes are 30-55 μm of micro-nano bioactivity glass, 0.1-5
Part grain size is 55-75 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes are 75-90 μm of micro-nano bioactivity glass, 0.1-
5 parts of nanometer hydroxyapatites, 25-50 parts of medical glycerines, 13-20 parts of sorbierites, 0.01-0.3 parts of medical polyethylene glycol-400,5-
50 parts of hydrated silicas, 0.01-0.55 parts of Acritamer 940s, 0.02-1.2 parts of xylitols, 0.05-2.0 parts of natural essences, 0.05-
3.5 parts of bay alcohol sulfuric esters are received, 0.01-0.55 parts of sodium cellulosates, 0.05-3.0 parts of citric acids, 0.5-10 parts of pure water, 0.5-1
Part C177891.
3. the toothpaste according to claim 1 containing bioactivity glass, it is characterised in that:Include in parts by weight following
Ingredient:0.05-1 parts of nano-bioactive glass, 0.1-5 parts of grain sizes are 0.5-1 μm of micro-nano bioactivity glass, 0.1-5 parts
Grain size is the micro-nano bioactivity glass of 1-5 μm of grade, 0.1-5 parts of grain sizes be 5-15 μm of micro-nano bioactivity glass, 0.1-5 parts
Grain size is 15-30 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes are 30-55 μm of micro-nano bioactivity glass, 0.1-5
Part grain size is 55-75 μm of micro-nano bioactivity glass, 0.1-5 parts of grain sizes are 75-90 μm of micro-nano bioactivity glass, 0.1-
5 parts of nanometer hydroxyapatites, 30-35 parts of D-sorbites, 18-20 parts of medical glycerines, 0.15-0.2 parts of medical polyethylene glycol-400,
28-29 parts of hydrated silicas, 0.6-0.7 parts of konjac glucomannans, 0.5-0.6 parts of mucopolysaccharides, 0.5-0.55 parts of natural essences, 0.28-0.29
Part soybean protein isolate, 0.35-0.36 parts of casein, 0.2-0.4 parts of Moringa extracts, 0.3-0.4 parts of butylated hydroxy anisoles,
10-11 parts of pure water, 0.5-0.6 parts of C177891.
4. the toothpaste according to claim 1 containing bioactivity glass, it is characterised in that:The micro-nano bioactivity
The preparation method of glass is:
(1)1-10 parts of 35-55 parts of quartz sand, 30-50 parts of calcium carbonate, 30-50 parts of sodium carbonate and phosphorus pentoxide are stirred evenly,
It is placed in pincers pot and is warming up to 1900 DEG C, 20 hours, obtain melt;
(2)Melt is quenched in the water of temperature≤20 DEG C, the volume ratio of melt and water is 1:10, it quenches and dissipates into transparent grain;
(3)Drying smashes classification powder in ceramic air-flow disintegrating machine.
5. the toothpaste according to claim 3 containing bioactivity glass, it is characterised in that:The Moringa extract is adopted
With hot water ultrasonic extraction, the Moringa that will be crushed after 20 parts of freeze-dryings, with 400-500ml distilled water at 80-90 DEG C of temperature
Ultrasonic extraction 14 hours, dry extract.
6. the preparation method of the toothpaste containing bioactivity glass, it is characterised in that:Include the following steps:
Step 1:Medical glycerine and Acritamer 940 are sufficiently stirred, stood for 24 hours;
Step 2:Sequentially add sorbierite, sodium cellulosate, xylitol, hydrated silica, medical polyethylene glycol-400, laruyl alcohol sulfuric acid
Ester is received, natural essence, 0.7-35 parts of micro-nano bioactivity glass, nano-bioactive glass, nanometer hydroxyapatite, pure
Water, citric acid and C177891, are sufficiently stirred to obtain the final product.
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Cited By (10)
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---|---|---|---|---|
CN109018663A (en) * | 2018-08-31 | 2018-12-18 | 沈杨 | There is the sucker toothpaste of decorative effect |
CN113440434A (en) * | 2021-06-17 | 2021-09-28 | 苏州百瑞敏生物技术有限公司 | Pregnant woman toothpaste containing bioactive glass and preparation method thereof |
CN113520912A (en) * | 2021-06-30 | 2021-10-22 | 苏州百瑞敏生物技术有限公司 | Toothpaste containing bioactive glass for middle-aged and elderly people and preparation method thereof |
CN113559000A (en) * | 2021-06-07 | 2021-10-29 | 苏州百瑞敏生物技术有限公司 | Children toothpaste containing bioactive glass and preparation method thereof |
CN113577293A (en) * | 2021-08-03 | 2021-11-02 | 上海森博生物科技有限公司 | Composition containing bioactive glass or analogue thereof, and preparation method and application thereof |
CN113786347A (en) * | 2021-10-27 | 2021-12-14 | 黄泽敏 | Toothpaste with oral disease prevention and treatment effects and preparation method thereof |
CN113827492A (en) * | 2021-11-29 | 2021-12-24 | 诺一迈尔(山东)医学科技有限公司 | Tooth desensitizing composition and preparation method thereof |
CN114533611A (en) * | 2022-02-16 | 2022-05-27 | 重庆登康口腔护理用品股份有限公司 | Composition capable of enhancing dentin sensitivity resistance effect of bioactive material and preparation method and application thereof |
CN114557897A (en) * | 2022-03-08 | 2022-05-31 | 江苏罗来雅实业股份有限公司 | Tooth-care paste containing bioactive glass and preparation process thereof |
CN115844737A (en) * | 2022-12-31 | 2023-03-28 | 广西信业生物技术有限公司 | Preparation method of bioactive mineral material for repairing enamel calcium |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1496244A (en) * | 2001-03-09 | 2004-05-12 | 肖特玻璃制造厂 | Use of bioactive glass in dental filling material |
CN1895209A (en) * | 2005-07-16 | 2007-01-17 | 洪滔 | Moringine toothpaste |
US20070258916A1 (en) * | 2006-04-14 | 2007-11-08 | Oregon Health & Science University | Oral compositions for treating tooth hypersensitivity |
CN107184403A (en) * | 2017-06-22 | 2017-09-22 | 缪来耿 | A kind of toothpaste and preparation method thereof |
-
2018
- 2018-01-24 CN CN201810068826.XA patent/CN108125806B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1496244A (en) * | 2001-03-09 | 2004-05-12 | 肖特玻璃制造厂 | Use of bioactive glass in dental filling material |
CN1895209A (en) * | 2005-07-16 | 2007-01-17 | 洪滔 | Moringine toothpaste |
US20070258916A1 (en) * | 2006-04-14 | 2007-11-08 | Oregon Health & Science University | Oral compositions for treating tooth hypersensitivity |
CN107184403A (en) * | 2017-06-22 | 2017-09-22 | 缪来耿 | A kind of toothpaste and preparation method thereof |
Cited By (12)
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CN109018663A (en) * | 2018-08-31 | 2018-12-18 | 沈杨 | There is the sucker toothpaste of decorative effect |
CN113559000A (en) * | 2021-06-07 | 2021-10-29 | 苏州百瑞敏生物技术有限公司 | Children toothpaste containing bioactive glass and preparation method thereof |
CN113440434A (en) * | 2021-06-17 | 2021-09-28 | 苏州百瑞敏生物技术有限公司 | Pregnant woman toothpaste containing bioactive glass and preparation method thereof |
CN113520912A (en) * | 2021-06-30 | 2021-10-22 | 苏州百瑞敏生物技术有限公司 | Toothpaste containing bioactive glass for middle-aged and elderly people and preparation method thereof |
CN113577293A (en) * | 2021-08-03 | 2021-11-02 | 上海森博生物科技有限公司 | Composition containing bioactive glass or analogue thereof, and preparation method and application thereof |
CN113577293B (en) * | 2021-08-03 | 2023-02-17 | 上海森博生物科技有限公司 | Composition containing bioactive glass or analogue thereof, and preparation method and application thereof |
CN113786347A (en) * | 2021-10-27 | 2021-12-14 | 黄泽敏 | Toothpaste with oral disease prevention and treatment effects and preparation method thereof |
CN113827492A (en) * | 2021-11-29 | 2021-12-24 | 诺一迈尔(山东)医学科技有限公司 | Tooth desensitizing composition and preparation method thereof |
CN114533611A (en) * | 2022-02-16 | 2022-05-27 | 重庆登康口腔护理用品股份有限公司 | Composition capable of enhancing dentin sensitivity resistance effect of bioactive material and preparation method and application thereof |
CN114533611B (en) * | 2022-02-16 | 2023-08-29 | 重庆登康口腔护理用品股份有限公司 | Composition capable of enhancing dentin sensitivity resisting effect of bioactive material and preparation method and application thereof |
CN114557897A (en) * | 2022-03-08 | 2022-05-31 | 江苏罗来雅实业股份有限公司 | Tooth-care paste containing bioactive glass and preparation process thereof |
CN115844737A (en) * | 2022-12-31 | 2023-03-28 | 广西信业生物技术有限公司 | Preparation method of bioactive mineral material for repairing enamel calcium |
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