CN108014061A - A kind of oral nursing liquid of effectively bacteriostasis, and deodorization - Google Patents
A kind of oral nursing liquid of effectively bacteriostasis, and deodorization Download PDFInfo
- Publication number
- CN108014061A CN108014061A CN201711452011.3A CN201711452011A CN108014061A CN 108014061 A CN108014061 A CN 108014061A CN 201711452011 A CN201711452011 A CN 201711452011A CN 108014061 A CN108014061 A CN 108014061A
- Authority
- CN
- China
- Prior art keywords
- liquid
- bacteriostasis
- oral nursing
- effectively
- nursing liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of oral nursing liquid of effectively bacteriostasis, and deodorization, including carbomer homopolymer, glycerine, saccharin sodium, citric acid, polysorbate, solvent, additionally including bacteriostatic agent, pH adjusting agent, natural botanical extraction liquid；According to the mass fraction, the ratio of each component is：0.3~1 part of carbomer homopolymer, 5~6 parts of glycerine, 0.4~1 part of saccharin sodium, 0.05~0.1 part of citric acid, 0.05~0.1 part of polysorbate, 90~100 parts of solvent, 1~2 part of bacteriostatic agent, 0.2~0.5 part of pH adjusting agent, 1~10 part of natural botanical extraction liquid.The oral cavity cleaning and nursing liquid of the present invention, can there is effective fresh breath, sterilization, anti-caries, the antioxygen power for strengthening tooth.Due to the addition of the natural extract of fragrant plant, Pure natural nontoxic side effect, while body immunity, pleasant mental and body can be strengthened.
Description
Technical field
The invention belongs to field of medical products, and in particular to a kind of oral nursing liquid of effectively bacteriostasis, and deodorization.
Background technology
(oral cavity) is gastral start-up portion in oral cavity.The health status in oral cavity is reflection life and health quality
Mirror.Oral hygiene focuses on controlling bacterial plaque, elimination dirt and swill, strengthens physiological stimulation, makes oral cavity
There is the good environment of a cleaning health with dentognathic system, so as to play its physiological function, safeguard oral health.
Common oral care is to maintain one of oral cleaning, prophylactic means.Oral cleaning can cause mouth not in time
The illnesss such as smelly, carious tooth, gingivitis, mucous hyperemia, canker sore, therefore it is very necessary to clean oral cavity.The portability of mouthwash and
Ease for operation has filled up the shortcoming that toothbrush and toothpaste cannot use at any time well.But existing mouthwash generally existing two is asked greatly
Topic：First, the alcohol content of alcohol type mouthwash is higher, excitement is strong when gargling, and be easy to cause drunk driving misunderstanding, while not
Suitable for children, alcohol intolerance person and the bad person of alcohol metabolism；Second, non-alcohol type mouthwash is generally using Cetylpyridinium Chloride, trichlorine
The antibiotic compositions such as life, thymol progress oral cavity is degerming, and long-time service is easily enriched with human body, causes side effect.
Usually health in addition to brushing teeth sooner or later in oral cavity, in recent years, the cleaning agent for mouth cavity liquid used is more, market at present
Present on cleaning agent for mouth cavity a great variety, but its bactericidal and bacteriostatic effect and its except halitosis effect is unsatisfactory.For example, China is specially
Profit application 201510725237.0 discloses a kind of cleaning agent for mouth cavity, and puckery containing tea extraction and persimmon, the oral cavity being prepared is clear
Clean dose be capable of providing it is gratifying remove halitosis effect, and tea extraction and persimmon is puckery has natural fragrance, smell during use
It is pleasant, but its removing taste effect is unsatisfactory.In another example Chinese patent application 2015480046813.2 discloses a kind of energy
It is enough to keep bactericidal effect for a long time and inhibit the liquid oral detergent using electrolysis water of metal protection, the liquid port
Chamber detergent is that have containing oxidation-reduction potential for positive electrolysis water, menthol, anionic surfactant and water solubility
Solvent and the liquid oral detergent that pH is 6-8, but its bactericidal effect is unsatisfactory.
At present in global range known about 200 kinds can be used for the fragrant plant of body-care because it is with many guarantors
Strong effect, and safe and non-toxic, wide application of the crowd, are always subject to the extensive concern of various countries.Its natural products is usually by fresh or dry
Dry plant tissue is refined and formed by steam distillation, supercritical methanol technology and organic solvent extractionprocess, refine gained essential oil and
Hydrosol mainly contains nearly hundred kinds of organic compounds such as various aldehydes, alcohols, alkenes.Therefore, if can be by this plant extracts
For oral care, have great significance, and market prospects.
The content of the invention
Goal of the invention：For shortcoming of the prior art, the present invention provides a kind of effectively degerming oral care
Liquid.
Technical solution：A kind of oral nursing liquid of effectively bacteriostasis, and deodorization provided by the present invention, including carbomer homopolymer,
Glycerine, saccharin sodium, citric acid, polysorbate, solvent, additionally including bacteriostatic agent, pH adjusting agent, natural botanical extraction liquid；
According to the mass fraction, the ratio of each component is：0.3~1 part of carbomer homopolymer, 5~6 parts of glycerine, 0.4~1 part of saccharin sodium, lemon
0.05~0.1 part of lemon acid, 0.05~0.1 part of polysorbate, 90~100 parts of solvent, 1~2 part of bacteriostatic agent, pH adjusting agent 0.2
~0.5 part, 1~10 part of natural botanical extraction liquid.
Further optimization formula, oral nursing liquid of the present invention, according to the mass fraction, the ratio of each component is：Card
0.5 part of ripple nurse homopolymer, 5 parts of glycerine, 0.4 part of saccharin sodium, 0.05 part of citric acid, 0.05 part of polysorbate, 100 parts of solvent, suppression
1 part of microbial inoculum, 0.3 part of pH adjusting agent, 1~10 part of natural botanical extraction liquid.
Specifically, the pH value of the oral nursing liquid is 5~7.5, dynamic viscosity is 2~3mPas, content of beary metal
<5μg/g。
Specifically, the bacteriostatic agent is phenmethylol.
Specifically, the pH adjusting agent is potassium hydroxide, phosphoric acid.
Specifically, the solvent is purified water.
Specifically, the natural botanical extraction liquid is rosemary extracting solution, extract solution from aloe, green tea extractive liquor.
Further, when natural botanical extraction liquid is rosemary, dosage is 4 parts；Natural botanical extraction liquid carries for aloe
Dosage is 10 parts when taking liquid；When natural botanical extraction liquid is green tea extractive liquor, dosage is 1 part.
Present invention also offers the collocation method of above-mentioned oral nursing liquid, include the following steps：
Solvent is added in agitator tank, is heated to 70~80 DEG C, adds carbomer homopolymer and saccharin sodium, until all molten
Solution；After above-mentioned steps stir evenly, citric acid and polysorbate are added in agitator tank, continue to stir；Natural plants are carried
Take liquid to be heated to 80 DEG C, then pour into immediately in above-mentioned agitator tank while hot, after stirring uniformly, natural cooling, using potassium hydroxide,
Phosphorus acid for adjusting pH is 7.0, to obtain the final product.
Beneficial effect：The oral cavity cleaning and nursing liquid of the present invention, can have effective fresh breath, sterilization, strengthen the anti-of tooth
Dental caries, antioxygen power.Due to the addition of the natural extract of fragrant plant, Pure natural nontoxic side effect, while human immunity can be strengthened
Power, pleasant mental and body.
Embodiment：
For the technical solution that the present invention is further explained, with reference to specific embodiment, it is carried out furtherly
It is bright, it is following to have chosen some exemplary embodiments, but and be not so limited the scope of application of this technology, embodiment is to illustrate this hair
It is bright and design, the concrete application of the present invention is not construed as limiting.
Embodiment 1
The formula of oral nursing liquid is (according to the mass fraction)：0.3 part of carbomer homopolymer, 5 parts of glycerine, saccharin sodium 0.4
Part, 0.05 part of citric acid, 0.05 part of polysorbate, 90 parts of solvent, 1 part of bacteriostatic agent, 0.2 part of pH adjusting agent, natural plants carry
Take 1 part of liquid.The bacteriostatic agent is phenmethylol.The pH adjusting agent is potassium hydroxide, phosphoric acid.The solvent is purifying
Water.The natural botanical extraction liquid is 4 parts of rosemary extracting solution.
Solvent is added in agitator tank, is heated to 70 DEG C, adds carbomer homopolymer and saccharin sodium, until all dissolvings；
After above-mentioned steps stir evenly, citric acid and polysorbate are added in agitator tank, continue to stir；By natural botanical extraction liquid
80 DEG C are heated to, is then poured into immediately in above-mentioned agitator tank while hot, after stirring uniformly, natural cooling, utilizes potassium hydroxide, phosphoric acid
It is 7.0 to adjust pH, to obtain the final product.The dynamic viscosity of obtained oral nursing liquid is 2mPas, content of beary metal<5μg/g.
Comparative example 1
Comparative example 1 is substantially the same manner as Example 1, and difference is, is not added with natural botanical extraction liquid.
Embodiment 2
The formula of oral nursing liquid is (according to the mass fraction)：1 part of carbomer homopolymer, 6 parts of glycerine, 1 part of saccharin sodium, lemon
0.1 part of lemon acid, 0.1 part of polysorbate, 100 parts of solvent, 2 parts of bacteriostatic agent, 0.5 part of pH adjusting agent, natural botanical extraction liquid 10
Part.The bacteriostatic agent is phenmethylol.The pH adjusting agent is potassium hydroxide, phosphoric acid.The solvent is purified water.Institute
The natural botanical extraction liquid stated is 10 parts of extract solution from aloe.
Solvent is added in agitator tank, is heated to 70-80 DEG C, adds carbomer homopolymer and saccharin sodium, until all molten
Solution；After above-mentioned steps stir evenly, citric acid and polysorbate are added in agitator tank, continue to stir；Natural plants are carried
Take liquid to be heated to 80 DEG C, then pour into immediately in above-mentioned agitator tank while hot, after stirring uniformly, natural cooling, using potassium hydroxide,
Phosphorus acid for adjusting pH is 7.0, to obtain the final product.The dynamic viscosity of obtained oral nursing liquid is 3mPas, content of beary metal<5μg/g.
Comparative example 2
Comparative example 2 is substantially the same manner as Example 2, and difference is, is not added with natural botanical extraction liquid.
Embodiment 3
Oral care is also formulated as (according to the mass fraction)：0.5 part of carbomer homopolymer, 5 parts of glycerine, 0.4 part of saccharin sodium,
0.05 part of citric acid, 0.05 part of polysorbate, 100 parts of solvent, 1 part of bacteriostatic agent, 0.3 part of pH adjusting agent, extracted form natural plant
8 parts of liquid.The bacteriostatic agent is phenmethylol.The pH adjusting agent is potassium hydroxide, phosphoric acid.The solvent is purifying
Water.The natural botanical extraction liquid is 1 part of green tea extractive liquor.
Solvent is added in agitator tank, is heated to 70 DEG C, adds carbomer homopolymer and saccharin sodium, until all dissolvings；
After above-mentioned steps stir evenly, citric acid and polysorbate are added in agitator tank, continue to stir；By natural botanical extraction liquid
80 DEG C are heated to, is then poured into immediately in above-mentioned agitator tank while hot, after stirring uniformly, natural cooling, utilizes potassium hydroxide, phosphoric acid
It is 7.0 to adjust pH, to obtain the final product.The dynamic viscosity of obtained oral nursing liquid is 2mPas, content of beary metal<5μg/g.
Comparative example 3
Comparative example 3 is substantially the same manner as Example 3, and difference is, is not added with natural botanical extraction liquid.
Embodiment 4 (biocidal property evaluation test)
Antibacterial type evaluation is carried out to the oral nursing liquid prepared by embodiment 1~3, comparative example 1~3.Subjects：It is international
Reference culture, streptococcus mutans (S.mutansIngbritt, serotype c) and the streptococcus sobrinus of streptococcus mutans race
(S.Sobrinus6715, serotype g).
Anaerobic culturel (CO in Trypsin Induced soybean broth (TSB) containing 1% sucrose280%th, N210%th,
H210%), to measure each cleaning agent for mouth cavity respectively using liquid/agar dilution extracorporeal bacteria inhibitor test streptococcic to two kinds minimum
Mlc and minimum bactericidal concentration.The minimum inhibitory concentration and minimum bactericidal concentration result of bacteria test are as shown in the table：
From experimental result, it is seen that the best results of embodiment 3.Meanwhile add the oral care of natural plant extracts
Liquid is better than being not added with the oral nursing liquid of natural botanical extraction liquid.
Embodiment 5 (sensory evaluation experiment)
Sensory evaluation experiment is carried out to the oral nursing liquid prepared by embodiment 1~3, comparative example 1~3.Selection 60 by
Examination person is tested, and subject is divided into 6 groups, every one group of 10 people, respectively using embodiment 1-3, comparative example after 1 cigarette of every group of suction
Cleaning agent for mouth cavity prepared by 1-3, to being compared afterwards therewith before using cleaning agent for mouth cavity and carrying out sensory evaluation scores.
The benchmark that scores is as follows：2 points：There is no smoke completely after use and smell is pleasant；1 point：Somewhat there is smoke after use：0
Point：Any improvement is not obtained using rear oral peculiar smell.Result of the test is as shown in the table：
| 0 point | 1 point | 2 points | Total score | |
| Embodiment 1 | 1 | 5 | 4 | 13 |
| Comparative example 1 | 2 | 5 | 3 | 11 |
| Embodiment 2 | 1 | 3 | 6 | 15 |
| Comparative example 2 | 2 | 6 | 2 | 10 |
| Embodiment 3 | 0 | 1 | 9 | 19 |
| Comparative example 3 | 0 | 1 | 9 | 19 |
From experimental result as can be seen that in terms of smell improvement, embodiment 3 is substantially better than embodiment 2, embodiment 1.
A kind of cavity conditioning liquid of effectively bacteriostasis, and deodorization proposed by the present invention, is described by preferred embodiment,
Related technical personnel can substantially not depart from present invention, process as described herein flow is being modified in spirit and scope
Or suitably change with combining, to realize the technology of the present invention.In particular, all similar replacements and change are to this
It is it will be apparent that being considered as being included in spiritual, scope and content of the invention for field technology personnel.
Claims (9)
1. it is a kind of effectively bacteriostasis, and deodorization oral nursing liquid, it is characterised in that the oral nursing liquid include carbomer homopolymer,
Glycerine, saccharin sodium, citric acid, polysorbate, solvent, additionally including bacteriostatic agent, pH adjusting agent, natural botanical extraction liquid；
According to the mass fraction, the ratio of each component is：0.3~1 part of carbomer homopolymer, 5~6 parts of glycerine, 0.4~1 part of saccharin sodium, lemon
0.05~0.1 part of lemon acid, 0.05~0.1 part of polysorbate, 90~100 parts of solvent, 1~2 part of bacteriostatic agent, pH adjusting agent 0.2
~0.5 part, 1~10 part of natural botanical extraction liquid.
2. the oral nursing liquid of effectively bacteriostasis, and deodorization according to claim 1, it is characterised in that the oral nursing liquid, is pressed
Mass fraction meter, the ratio of each component is：0.5 part of carbomer homopolymer, 5 parts of glycerine, 0.4 part of saccharin sodium, 0.05 part of citric acid,
0.05 part of polysorbate, 100 parts of solvent, 1 part of bacteriostatic agent, 0.3 part of pH adjusting agent, 8 parts of natural botanical extraction liquid.
3. the oral nursing liquid of effectively bacteriostasis, and deodorization according to claim 1, it is characterised in that the oral nursing liquid
PH value be 5~7.5, dynamic viscosity is 2~3mPas, content of beary metal<5μg/g.
4. the oral nursing liquid of effectively bacteriostasis, and deodorization according to claim 1, it is characterised in that the bacteriostatic agent is benzene
Methanol.
5. the oral nursing liquid of effectively bacteriostasis, and deodorization according to claim 1, it is characterised in that the pH adjusting agent
For potassium hydroxide, phosphoric acid.
6. the oral nursing liquid of effectively bacteriostasis, and deodorization according to claim 1, it is characterised in that the solvent is purifying
Water.
7. the oral nursing liquid of effectively bacteriostasis, and deodorization according to claim 1, it is characterised in that the natural plants carry
Liquid is taken as rosemary extracting solution, extract solution from aloe, green tea extractive liquor.
8. the oral nursing liquid of effectively bacteriostasis, and deodorization according to claim 1, it is characterised in that work as natural botanical extraction liquid
For rosemary when dosage be 4 parts；Dosage is 10 parts when natural botanical extraction liquid is extract solution from aloe；When natural botanical extraction liquid is
Dosage is 1 part during green tea extractive liquor.
9. the collocation method of the oral nursing liquid of effective bacteriostasis, and deodorization described in claim 1, it is characterised in that including following step
Suddenly：
Solvent is added in agitator tank, is heated to 70~80 DEG C, adds carbomer homopolymer and saccharin sodium, until all dissolvings；
After above-mentioned steps stir evenly, citric acid and polysorbate are added in agitator tank, continue to stir；By natural botanical extraction liquid
80 DEG C are heated to, is then poured into immediately in above-mentioned agitator tank while hot, after stirring uniformly, natural cooling, utilizes potassium hydroxide, phosphoric acid
It is 7.0 to adjust pH, to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711452011.3A CN108014061A (en) | 2017-12-27 | 2017-12-27 | A kind of oral nursing liquid of effectively bacteriostasis, and deodorization |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711452011.3A CN108014061A (en) | 2017-12-27 | 2017-12-27 | A kind of oral nursing liquid of effectively bacteriostasis, and deodorization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108014061A true CN108014061A (en) | 2018-05-11 |
Family
ID=62072035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711452011.3A Pending CN108014061A (en) | 2017-12-27 | 2017-12-27 | A kind of oral nursing liquid of effectively bacteriostasis, and deodorization |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108014061A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112220699A (en) * | 2019-07-15 | 2021-01-15 | 陕西佰傲再生医学有限公司 | Oral care compositions |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830128A (en) * | 2012-11-21 | 2014-06-04 | 苏州鑫贝瑞药业有限公司 | Novel care solution and applications thereof |
| CN105232781A (en) * | 2015-11-05 | 2016-01-13 | 周菊香 | Spray for removing bad breath, and preparation method thereof |
| CN106466482A (en) * | 2015-08-20 | 2017-03-01 | 康多宝医疗健康产品（湖南）有限公司 | A kind of compositionss of prevention, treatment or suppression membrane disease and preparation method thereof |
| CN106793784A (en) * | 2014-03-10 | 2017-05-31 | 纽约市哥伦比亚大学理事会 | Vegetalitas antimicrobial compositions |
-
2017
- 2017-12-27 CN CN201711452011.3A patent/CN108014061A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830128A (en) * | 2012-11-21 | 2014-06-04 | 苏州鑫贝瑞药业有限公司 | Novel care solution and applications thereof |
| CN106793784A (en) * | 2014-03-10 | 2017-05-31 | 纽约市哥伦比亚大学理事会 | Vegetalitas antimicrobial compositions |
| CN106466482A (en) * | 2015-08-20 | 2017-03-01 | 康多宝医疗健康产品（湖南）有限公司 | A kind of compositionss of prevention, treatment or suppression membrane disease and preparation method thereof |
| CN105232781A (en) * | 2015-11-05 | 2016-01-13 | 周菊香 | Spray for removing bad breath, and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 蔡向红: "《本草纲目方药精选》", 31 May 2014, 陕西科学技术出版社2014年5月第1版 * |
| 薛立军，尹庆民: "《应用型人才培养的探索与实践》", 28 February 2009, 知识产权出版社2009年2月第1版 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112220699A (en) * | 2019-07-15 | 2021-01-15 | 陕西佰傲再生医学有限公司 | Oral care compositions |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100560054C (en) | Oral cleaning composition | |
| CN101249056B (en) | Anti-inflammation gargle water and method of preparing the same | |
| CN107184476A (en) | A kind of antibacterial mouthwash and preparation method thereof | |
| CN105310960B (en) | A kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof | |
| CN102512345B (en) | Natural antibacterial gargle and preparation method thereof | |
| CN108685835A (en) | A kind of multifunctional gargle | |
| CN108464956A (en) | A kind of composition and the preparation method and application thereof applied to oral cavity | |
| CN108014070A (en) | Visualization propolis acidity mouthwash of hemostasis and anti-inflammation and preparation method thereof | |
| CN106924162A (en) | A kind of application of plant additive, bacteriostatic agent, oral care product and plant additive in oral care product is prepared | |
| EA022115B1 (en) | Composition for oral cavity hygiene | |
| CN107693430A (en) | Draft nurses one's health antibacterial gargle | |
| CN108042420A (en) | A kind of composition and its application for oral health | |
| JP2021502325A (en) | Effervescent solid agent for oral cleaning and its manufacturing method | |
| CN107095827A (en) | One kind is antibacterial to remove stain Chinese medicinal toothpaste and preparation method thereof | |
| CN107049828A (en) | A kind of anti-caries toothpaste and preparation method thereof | |
| CN108324661B (en) | Beta-cyclodextrin-based antibacterial anti-inflammatory and halitosis-removing mouth wash and preparation method thereof | |
| TW201034697A (en) | Dentifrice composition | |
| CN109010098A (en) | Antimicrobial mouthwash and preparation method thereof | |
| CN108014061A (en) | A kind of oral nursing liquid of effectively bacteriostasis, and deodorization | |
| CN107375168A (en) | A kind of anti-caries toothpaste of American-cockroach-extract-containing | |
| CN105168086B (en) | Traditional Chinese medicine composition, compound particles containing traditional Chinese medicine composition, toothpaste and preparation method of toothpaste | |
| JP2021020869A (en) | Oral indigenous bacteria growth promoter, and oral composition | |
| CN103599182A (en) | Traditional Chinese medicine composition and preparation method thereof, and oral cavity cleaning and nursing product and preparation method thereof | |
| CN107281021B (en) | Pure natural alcohol-free oral cleaning care solution | |
| CN107320401A (en) | A kind of mouthwash of pre- anti-caries and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Liu Zheng Inventor after: Gao Yifei Inventor after: Zeng Ming Inventor after: Cai Lisong Inventor before: Gao Yifei Inventor before: Zhang Maofeng Inventor before: Cai Lisong Inventor before: Chen Ruizhu |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180511 |