CN102106854A - Application of sinomenine to preparation of analgesic drug - Google Patents
Application of sinomenine to preparation of analgesic drug Download PDFInfo
- Publication number
- CN102106854A CN102106854A CN 200910256431 CN200910256431A CN102106854A CN 102106854 A CN102106854 A CN 102106854A CN 200910256431 CN200910256431 CN 200910256431 CN 200910256431 A CN200910256431 A CN 200910256431A CN 102106854 A CN102106854 A CN 102106854A
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- China
- Prior art keywords
- sinomenine
- agent
- analgesic drug
- application
- preparation
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to novel medicinal application of sinomenine, in particular to application of the sinomenine to the preparation of an analgesic drug and belongs to the field of Chinese medicines. When the sinomenine and pharmaceutically-acceptable salts thereof are used for preparing the analgesic drug, pharmaceutically-general excipients such as bonding agent, disintegrating agent, filling agent, lubricating agent, preservative, solubilizing agent, flavoring agent, solvent, emulsifying agent, and the like can be added. The sinomenine and pharmaceutically-acceptable salts thereof can be combined with other compatible treatment drugs to prepare medicament when being used for preparing the analgesic drug.
Description
Technical field
The invention relates to the new medicine use invention of sinomenine, specifically is the application of sinomenine in the preparation analgesic drug product, belongs to drug world.
Technical background
Sinomenine is one of alkaloid that extracts from stem of menispermaceae plant Sinomenium acutum and root, is a kind of known medical substance.Modern pharmacology studies show that sinomenine has multiple pharmacological effect.The main pharmacological of present known sinomenine of putting it briefly is as follows: effects such as antiinflammatory, blood pressure lowering, inhibition maincenter, arrhythmia; Body nonspecific immunity, cellular immunization and humoral immunization all there are inhibitory action, especially the lymphocytic function of T are had stronger inhibitory action; Sinomenine is again a kind of histamine liberators, and it is evident in efficacy to be used for the treatment of rheumatoid arthritis clinically.Up to the present, also there is not relevant sinomenine to be used for the analgesic report.
Sinomenine has had product to sell as a kind of medicine, for example, the sinomenine that area, Qianyang, Hunan pharmaceutical factory produces (sinomenime, SIN), the sinomenine hydrochloride powder that connection pharmaceutical factory produces in the Wuhan City etc.
Therefore, sinomenine according to the formulation method of routine, can be prepared into any pharmaceutical dosage form that is suitable for using clinically as treatment treatment of pain medicine, for example, and tablet, capsule, electuary, oral agents, Emulsion, injection, suppository, unguentum etc.
Summary of the invention
Except the said sinomenine of the present invention, acceptable salt on the materia medica of sinomenine, for example sinomenine hydrochloride has the analgesic effect equally, and therefore, the application in the preparation analgesic drug product of sinomenine and pharmaceutical salts thereof all belongs to protection scope of the present invention.
Acceptable salt can add excipient commonly used on the materia medica on sinomenine and the materia medica thereof when being used to prepare analgesic drug product, as, binding agent, disintegrating agent, filler, lubricant, antiseptic, solubilizing agent, flavoring agent, solvent, emulsifying agent etc.Acceptable salt also can be made medicament by the medicine compatible with other together on sinomenine and the materia medica thereof when being used to prepare analgesic drug product.
Embodiment 1
Sinomenine hydrochloride powder 25000mg, medical starch 250g, an amount of pelletize of ethanol, drying is advanced the tablet machine tabletting, makes 1000, and every sheet heavily is 275mg, hydrochloric sinomenine 25mg.
Embodiment 2
Sinomenine 2000mg, starch 180g, the two fully mixes, and is encapsulated, makes 2000 capsules, and every 0.1g is heavy, hydrochloric sinomenine 10mg.
The present invention relates to the application of acceptable salt in the preparation analgesic drug product on sinomenine and the materia medica thereof.According to the preparation technique of routine, sinomenine, sinomenine hydrochloride etc. can be made various medicaments, be used for pain relieving.
The commodity preparation of sinomenine is existing to be sold, and its active component of commercially available ZHENGQINGFENGTONGNING promptly is a sinomenine.Therefore the application's experimental drug is with the statement of trade name ZHENGQINGFENGTONGNING, and the drug function of sinomenine has been represented in its effect.
Claims (3)
1. the application of sinomenine in the preparation analgesic drug product is characterized in that the application in the preparation analgesic drug product of sinomenine and pharmaceutical salts thereof.
2. according to claim 1, sinomenine and pharmaceutical salts thereof can be used to prepare the medicine for the treatment of postoperative pain, sinomenine, sinomenine hydrochloride etc. can be made various medicaments, are used for pain relieving.
3. according to claim 1, the application of acceptable salt in the preparation analgesic drug product on sinomenine and the materia medica thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910256431 CN102106854A (en) | 2009-12-25 | 2009-12-25 | Application of sinomenine to preparation of analgesic drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910256431 CN102106854A (en) | 2009-12-25 | 2009-12-25 | Application of sinomenine to preparation of analgesic drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102106854A true CN102106854A (en) | 2011-06-29 |
Family
ID=44171210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200910256431 Pending CN102106854A (en) | 2009-12-25 | 2009-12-25 | Application of sinomenine to preparation of analgesic drug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102106854A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579445A (en) * | 2012-03-02 | 2012-07-18 | 李蕴麟 | Application of sinomenine or pharmaceutically acceptable salt thereof as medicament for preventing and treating pulmonary interstitial fibrosis |
| CN102813924A (en) * | 2012-05-17 | 2012-12-12 | 高同强 | Drug combination product for analgesia based on sinomenine |
| CN102961295A (en) * | 2012-12-14 | 2013-03-13 | 柳州两面针股份有限公司 | Application of caulis sinomenii extract to preparation of oral care products |
-
2009
- 2009-12-25 CN CN 200910256431 patent/CN102106854A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579445A (en) * | 2012-03-02 | 2012-07-18 | 李蕴麟 | Application of sinomenine or pharmaceutically acceptable salt thereof as medicament for preventing and treating pulmonary interstitial fibrosis |
| CN102579445B (en) * | 2012-03-02 | 2013-10-16 | 李蕴麟 | Application of sinomenine or pharmaceutically acceptable salt thereof as medicament for preventing and treating pulmonary interstitial fibrosis |
| CN102813924A (en) * | 2012-05-17 | 2012-12-12 | 高同强 | Drug combination product for analgesia based on sinomenine |
| CN102813924B (en) * | 2012-05-17 | 2014-06-18 | 高同强 | Drug combination product for analgesia based on sinomenine |
| CN102961295A (en) * | 2012-12-14 | 2013-03-13 | 柳州两面针股份有限公司 | Application of caulis sinomenii extract to preparation of oral care products |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110629 |