CN102488684B - Application of sumatriptan in preparation of medicines for preventing and treating narcomania - Google Patents
Application of sumatriptan in preparation of medicines for preventing and treating narcomania Download PDFInfo
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- CN102488684B CN102488684B CN 201110457284 CN201110457284A CN102488684B CN 102488684 B CN102488684 B CN 102488684B CN 201110457284 CN201110457284 CN 201110457284 CN 201110457284 A CN201110457284 A CN 201110457284A CN 102488684 B CN102488684 B CN 102488684B
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- sumatriptan
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Abstract
The invention provides a novel application of sumatriptan or its pharmaceutically acceptable salt in preparation of medicines for preventing and treating opioid dependence symptoms. The invention also provides a novel application of a preparation containing sumatriptan or its pharmaceutically acceptable salt in preparation of medicines for preventing and treating opioid dependence symptoms. Compared with the current medicines for preventing and treating opioid dependence symptoms, the sumatriptan has the advantages of definite therapeutic effect as well as small toxic and side effect, and can be an ideal drug rehabilitation medicine for administration.
Description
Technical field
The present invention relates to anti-additive medicament, sumatriptan or its pharmaceutically acceptable salt application in the medicine of preparation prevention or treatment opioid dependent symptoms of more specifically saying so.
Background technology
At present, it is all very big to social security and human health damage to take drugs, and in worldwide, is listed as serious social effects of pollution with environmental pollution, climate warming.Because the addiction after drugs are sucked makes the smoker be difficult to give up.At present the detoxification medicine can be divided into substantially: weak addicted opioid receptor agonist, as methadone etc.; The opiate receptor blocker is as naltrexone etc.; The non-opium medicine is as α-2 norepinephrine receptor agonist clonidine or lofexidine etc.; M nachr antagonist scopolamine and Anisodamine etc.; Chinese medicine preparation.These medicines truly have certain drug abstinence, but because drug user's psychic dependence height, and also there is certain addiction in alternative medicine itself, junkie is given up back relapse rate height; Though Chinese medicine does not have addiction, uncertain therapeutic efficacy is cut, and the curative effect fluctuation range is big.Therefore, still need determined curative effect in this area, do not have addicted anti-additive medicament.
Sumatriptan is at present clinically as the migrainous drug use for the treatment of, be used for the adult tendency or the migrainous acute attack of absence of aura are arranged, " Sumatriptan Succinate oral formulations description " referring to State Food and Drug Administration's promulgation, state's food medicine prison is annotated [2010] No. 200, arrives by reference herein as a reference in full.The chemical name of Sumatriptan Succinate is 3-[2-(dimethylamino) ethyl]-N-methylindole-5-amsacrine succinate.Its chemical structural formula is as follows:
The unexpected discovery of the inventor, sumatriptan have the effect of stronger inhibition morphine abstinence syndrome symptom, and do not have addiction, can be used as anti-additive medicament and are used for control opioid dependent symptoms.
Summary of the invention
The invention provides the application in the medicine of preparation prevention or treatment opioid dependent symptoms of sumatriptan or its pharmaceutically acceptable salt.The preferred Sumatriptan Succinate of the pharmaceutically acceptable salt of sumatriptan wherein.
The present invention also provides the application of the preparation that comprises sumatriptan or its pharmaceutically acceptable salt in the medicine of preparation prevention or treatment opioid dependent symptoms.Described preparation is for comprising sumatriptan or its pharmaceutically acceptable salt, and the preparation of medicament technology preparation routinely is as powder spray, aerosol, oral liquid, tablet, capsule, injection, patch.Wherein preferred powder spray, aerosol.
Beneficial effect (comparison of giving up active and existing anti-additive medicament of Sumatriptan Succinate)
One. material
1. laboratory animal
Male mice in kunming, body weight 18-22g is provided by Zhongshan University's Experimental Animal Center.
2. trial drug
The morphine sulfate injection, Qinghai Pharmaceutic Plant produces, lot number: 2010051209;
Naloxone hydrochloride injection, Fourth Ring, Beijing pharmaceutical factory produces, lot number: 10082205;
Clonidine hydrochloride, sky, Suizhou, Hubei medical sci-tech company provides lot number: 10021113.
Two. method
1. administration
Reference literature model (Gen Pharmacol, 1994,25 (7): 1505-1510), adopt the subcutaneous injection incremental method to set up morphine and rely on model.Male Kunming strain mice, 8 every group.On-test, respectively organized the subcutaneous injection morphine sulfate, every day 3 times, continuous 7 days.Starting dose is 5mg/kg, and double later every day, reaches 160mg/kg by the 6th day, is maintained to the 7th day.After the last administration 2.5 hours, each was organized under the mouse peritoneum administration or gives normal saline, and injection naloxone 4.5mg/kg under each mouse peritoneum observes mouse jump number of times in 15 minutes immediately after 30 minutes.The results are shown in Table 1:
The comparison of table 1 Sumatriptan Succinate and clonidine inhibition morphine-dependent mice withdrawal symptom (n=10, x ± s)
Compare * P＜0.05, * * P＜0.01 with morphine dependence group; Compare #P＞0.05 with clonidine
2. date processing
(x ± s) expression carries out statistical procedures with student t check to data with mean ± standard deviation.
The result draws by table 1: high, medium and low dosage group Sumatriptan Succinate is compared mice with morphine dependence group withdrawal symptom exists significantly or extremely remarkable significant difference; High, medium and low dosage group Sumatriptan Succinate is compared no remarkable significant difference with clonidine group, prove that Sumatriptan Succinate can be used as anti-additive medicament and uses.The result proves that Sumatriptan Succinate has the prevention that obviously is better than prior art and the effect for the treatment of the opioid dependent symptoms, can be used as anti-additive medicament and uses.
The specific embodiment
Further specify technical scheme of the present invention below by specific embodiment, only the invention will be further described for these embodiment with additional, the invention is not restricted to these embodiment.
Embodiment 1
The preparation of sumatriptan powder spray
Sumatriptan Succinate 40g
Lactose 960g
Make 1000
Get Sumatriptan Succinate and cross 200 mesh sieves, will not pulverize with jet mill by the macroparticle of sieve, cross 200 mesh sieves, two batches of fine powders by 200 mesh sieves are merged, standby; Get lactose and prepare the lactose fine powder as stated above; Take by weighing standby Sumatriptan Succinate, the lactose of recipe quantity respectively, stir down, in batches, alternately add the V-type mixing channel, mix homogeneously is pressed 1g powder/grain, and filled capsules namely gets the sumatriptan powder spray, passes through special-purpose doser per nasal inhalation during use.
Embodiment 2
The preparation of sumatriptan aerosol
Sumatriptan Succinate 20g
Potassium sorbate is an amount of
Deionized water is an amount of
Make 1000ml
Get the recipe quantity Sumatriptan Succinate, add the appropriate amount of deionized water dissolving, add an amount of potassium sorbate dissolving again, stir, filter, filtrate adds deionized water to 1000ml, presses the 20ml/ bottle, adds pressure vessel, container is airtight, charge into tetrafluoroethane, namely get the sumatriptan aerosol.
Claims (4)
1. sumatriptan or its pharmaceutically acceptable salt application in the medicine of preparation prevention or treatment morphine dependent symptoms.
2. purposes as claimed in claim 1, wherein the salt of sumatriptan is Sumatriptan Succinate.
3. comprise the application of preparation in the medicine of preparation prevention or treatment morphine dependent symptoms of sumatriptan or its pharmaceutically acceptable salt.
4. purposes as claimed in claim 3, wherein said preparation is powder spray, aerosol, tablet, capsule, injection, oral liquid or patch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110457284 CN102488684B (en) | 2011-12-30 | 2011-12-30 | Application of sumatriptan in preparation of medicines for preventing and treating narcomania |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110457284 CN102488684B (en) | 2011-12-30 | 2011-12-30 | Application of sumatriptan in preparation of medicines for preventing and treating narcomania |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102488684A CN102488684A (en) | 2012-06-13 |
| CN102488684B true CN102488684B (en) | 2013-08-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110457284 Expired - Fee Related CN102488684B (en) | 2011-12-30 | 2011-12-30 | Application of sumatriptan in preparation of medicines for preventing and treating narcomania |
Country Status (1)
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| CN (1) | CN102488684B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101134025A (en) * | 2007-10-10 | 2008-03-05 | 南昌弘益科技有限公司 | Hydrochloric acid flunarizine dropping pills |
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2011
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| CN102488684A (en) | 2012-06-13 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130828 Termination date: 20171230 |