CN102379915A - Olive effervescent tablet and preparation method thereof - Google Patents
Olive effervescent tablet and preparation method thereof Download PDFInfo
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- CN102379915A CN102379915A CN2011103270704A CN201110327070A CN102379915A CN 102379915 A CN102379915 A CN 102379915A CN 2011103270704 A CN2011103270704 A CN 2011103270704A CN 201110327070 A CN201110327070 A CN 201110327070A CN 102379915 A CN102379915 A CN 102379915A
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Abstract
The invention discloses an olive effervescent tablet and a preparation method thereof. The effervescent tablet is prepared from the following raw materials in parts by weight: 2 to 6 parts of olive, 2 to 6 parts of loquat flower, 1 to 5 parts of sarcandra glabra, and 1 to 3 parts of siraitia grosvenorii. The olive effervescent tablet prepared by the method has the functions of clearing and moistening laryngopharynx, soothing chest and nourishing lung, and diminishing swelling and relieving pain; the tablet performs acid base reactions in water before administration and is disintegrated quickly, so that the bioavailability of the medicament is improved, the color and smell can be regulated flexibly. The olive effervescent tablet is suitable for various people, in particular children, old people and patients being incapable of swallowing.
Description
Technical field
The present invention relates to the pharynx-clearing throat-benefiting product, be specifically related to a kind of Fructus Canarii albi effervescent tablet and preparation method thereof.
Background technology
Pharyngitis is a kind of common disease, can be divided into acute and chronic two big types according to the course of disease, and motherland's medical science system is referred to as " sore throat ".
Pharynx is human body and the extraneous thoroughfare that communicates, and has important defence, breathes, swallows, function such as sounding sympathetic response.The pathological change that the acute and chronic inflammation of pharynx causes; Not only cause the partial malfunction of pharynx, also can involve the adjacent organs tissue, even influence other system of whole body; Being healthy commonly encountered diseases, frequently-occurring disease of harm humans, also is the occupation disease of many industries such as teacher, traffic police simultaneously.Its sickness rate of clinical report accounts for the 10%-20% of laryngeal disease, and the trend that rises is year by year arranged.Yet, present rare specific medicament evident in efficacy and easy to use.
Summary of the invention
The object of the present invention is to provide a kind of Fructus Canarii albi effervescent tablet and preparation method thereof; It has the function of throat-benefiting, the chest stuffiness relieving lung moistening, reducing swelling and alleviating pain, before taking acid-base reaction takes place in water, and disintegrate is rapid; Help improving drug bioavailability; Its color, smell and taste can flexible, is applicable to all kinds of crowds, especially child, old man and the patient that can not swallow.
For realizing above-mentioned purpose, the present invention adopts following technical scheme:
The raw material of Fructus Canarii albi effervescent tablet and the mass fraction of each raw material: Fructus Canarii albi 2-6 part, Flos Eriobotryae 2-6 part, Herba Pileae Scriptae 1-5 part, Fructus Momordicae 1-3 part.The concrete steps of its preparation method are following:
(1) takes by weighing Fructus Canarii albi, Flos Eriobotryae, Herba Pileae Scriptae, Fructus Momordicae by proportioning raw materials, mix and pulverize, add raw material gross weight 1-3 ethanol doubly, under the condition of 35 ℃-55 ℃ of temperature and pressure 30MPa-40MPa, carry out CO
2Supercritical extraction 2 hours-4 hours obtains the Chinese medicine extract;
(2) get the Chinese medicine extract that step (1) obtains, add its weight 1-2 lactose and starch doubly, 60-70 ℃ of dry 2-3h is ground into 180-220 purpose fine powder, is divided into 2 parts, and be subsequent use; The weight ratio of described lactose and starch is 3:2;
(3) getting 1 part of the fine powder that step (2) obtains, add its weight 0.5-1.5 citric acid doubly, is that the starch slurry of 10%-15% is a binding agent with the mass fraction, and 18 orders are granulated, and 50 ℃ of-55 ℃ of dry 1-2h make the acid grain;
(4) getting 1 part of the fine powder that step (2) obtains, add its weight 0.5-1.5 sodium bicarbonate doubly, is that the starch slurry of 10%-15% is a binding agent with the mass fraction, and 18 orders are granulated, and 50 ℃ of-55 ℃ of dry 1-2h make the alkali grain;
(5) with step (3) drying acid grain and step (4) drying alkali grain mix homogeneously completely completely, cross 20 mesh sieve granulate, add the magnesium stearate mix homogeneously of dried particle weight 0.1%-1%, tabletting promptly gets described Fructus Canarii albi effervescent tablet.
The major function of each medicine among the present invention:
Fructus Canarii albi: sore-throat relieving, promote the production of body fluid detoxifcation.Be used for laryngopharynx swelling and pain, cough, excessive thirst, the poisoning of fish Eriocheir sinensis.
Flos Eriobotryae: have and wet one's whistle, lung moistening, preventing phlegm from forming and stopping coughing, control functions such as headache, cold, abnormal smells from the patient delicate fragrance, little sweet contains multivitamin, has unique health-care effect.Research and analyse and show that Flos Eriobotryae is nutritious, especially contain higher nutrient calcium, ferrum, zinc etc.In addition, Flos Eriobotryae is rich in 18 seed amino acids, and especially 8 seed amino acid content of needed by human are all higher.
Herba Pileae Scriptae: anti-inflammation, expelling wind and removing dampness, promoting blood circulation and stopping pain.Control pneumonia, acute appendicitis, acute gastroenteritis, bacillary dysentery, rheumatalgia, traumatic injury, fracture.
Fructus Momordicae: clearing heat and moistening lung, laxation relieving constipation.Be used for lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.Fructus Momordicae is sweet, sour; Cool in nature; Clearing away heat and cooling blood is arranged, effects such as the cough-relieving of promoting the production of body fluid, laxation toxin expelling, skin care benefit face, moistening the lung and resolving phlegm; Can be used for life prolonging, preserve youthful looks Yue Se and treatment phlegm-heat cough, laryngopharynx swelling and pain, constipation, the irritated all disease of quenching one's thirst, control respiratory tract infection and anticancer effect are arranged again.
Remarkable advantage of the present invention is:
(1) this Fructus Canarii albi effervescent tablet has multiple functions such as throat-benefiting, the chest stuffiness relieving lung moistening, anti-inflammation, reducing swelling and alleviating pain, to various slow, acute pharyngitis is evident in efficacy.
(2) this Fructus Canarii albi effervescent tablet has no stimulation to oral mucosa, local skin anaphylaxis or systemic anaphylaxis also do not occur, and is safe in utilization.
(3) this Fructus Canarii albi effervescent tablet preparation formulation is suitable: acid-base reaction takes place in water before taking; Disintegrate is rapid, helps improving drug bioavailability, and color, smell and taste can flexible; All be suitable for the patient who is particularly useful for child, old man and can not swallows for all kinds of crowds.
The specific embodiment
Embodiment 1
The raw material of Fructus Canarii albi effervescent tablet and the mass fraction of each raw material: 2 parts of Fructus Canarii albis, 2 parts of Flos Eriobotryae, 1 part of Herba Pileae Scriptae, 1 part of Fructus Momordicae.The concrete steps of its preparation method are following:
(1) takes by weighing Fructus Canarii albi, Flos Eriobotryae, Herba Pileae Scriptae, Fructus Momordicae by proportioning raw materials, mix and pulverize, add the ethanol of the identical gross weight of raw material, under the condition of 35 ℃ of temperature and pressure 30MPa, carry out CO
2Supercritical extraction 2 hours obtains the Chinese medicine extract;
(2) get the Chinese medicine extract that step (1) obtains, add the lactose and the starch of identical weight, 60 ℃ of dry 2h are ground into 180 purpose fine powders, are divided into 2 parts, and are subsequent use; The weight ratio of described lactose and starch is 3:2;
(3) getting 1 part of the fine powder that step (2) obtains, add the citric acid of 0.5 times of its weight, is that 10% starch slurry is a binding agent with mass fraction, and 18 orders are granulated, and 50 ℃ of dry 1h make the acid grain;
(4) getting 1 part of the fine powder that step (2) obtains, add the sodium bicarbonate of 0.5 times of its weight, is that 10% starch slurry is a binding agent with mass fraction, and 18 orders are granulated, and 50 ℃ of dry 1h make the alkali grain;
(5) with step (3) drying acid grain and step (4) drying alkali grain mix homogeneously completely completely, cross 20 mesh sieve granulate, add the magnesium stearate mix homogeneously of dried particle weight 0.1%, tabletting promptly gets described Fructus Canarii albi effervescent tablet.
Embodiment 2
The raw material of Fructus Canarii albi effervescent tablet and the mass fraction of each raw material: 6 parts of Fructus Canarii albis, 6 parts of Flos Eriobotryae, 5 parts of Herba Pileae Scriptaes, 3 parts of Fructus Momordicaes.The concrete steps of its preparation method are following:
(1) takes by weighing Fructus Canarii albi, Flos Eriobotryae, Herba Pileae Scriptae, Fructus Momordicae by proportioning raw materials, mix and pulverize, add the ethanol of 3 times of raw material gross weights, under the condition of 55 ℃ of temperature and pressure 40MPa, carry out CO
2Supercritical extraction 4 hours obtains the Chinese medicine extract;
(2) get the Chinese medicine extract that step (1) obtains, add the lactose and the starch of 2 times of its weight, 70 ℃ of dry 3h are ground into 220 purpose fine powders, are divided into 2 parts, and are subsequent use; The weight ratio of described lactose and starch is 3:2;
(3) getting 1 part of the fine powder that step (2) obtains, add the citric acid of 1.5 times of its weight, is that 15% starch slurry is a binding agent with mass fraction, and 18 orders are granulated, and 55 ℃ of dry 2h make the acid grain;
(4) getting 1 part of the fine powder that step (2) obtains, add the sodium bicarbonate of 1.5 times of its weight, is that 15% starch slurry is a binding agent with mass fraction, and 18 orders are granulated, and 55 ℃ of dry 2h make the alkali grain;
(5) with step (3) drying acid grain and step (4) drying alkali grain mix homogeneously completely completely, cross 20 mesh sieve granulate, add the magnesium stearate mix homogeneously of dried particle weight 1%, tabletting promptly gets described Fructus Canarii albi effervescent tablet.
Embodiment 3
The raw material of Fructus Canarii albi effervescent tablet and the mass fraction of each raw material: 2 parts of Fructus Canarii albis, 3 parts of Flos Eriobotryae, 4 parts of Herba Pileae Scriptaes, 2 parts of Fructus Momordicaes.The concrete steps of its preparation method are following:
(1) takes by weighing Fructus Canarii albi, Flos Eriobotryae, Herba Pileae Scriptae, Fructus Momordicae by proportioning raw materials, mix and pulverize, add the ethanol of 2 times of raw material gross weights, under the condition of 45 ℃ of temperature and pressure 35MPa, carry out CO
2Supercritical extraction 3 hours obtains the Chinese medicine extract;
(2) get the Chinese medicine extract that step (1) obtains, add its weight 1-2 lactose and starch doubly, 65 ℃ of dry 2.5h are ground into 200 purpose fine powders, are divided into 2 parts, and are subsequent use; The weight ratio of described lactose and starch is 3:2;
(3) getting 1 part of the fine powder that step (2) obtains, add the citric acid of identical weight, is that 12% starch slurry is a binding agent with mass fraction, and 18 orders are granulated, and 52 ℃ of dry 1.5h make the acid grain;
(4) getting 1 part of the fine powder that step (2) obtains, add the sodium bicarbonate of identical weight, is that 12% starch slurry is a binding agent with mass fraction, and 18 orders are granulated, and 52 ℃ of dry 1.5h make the alkali grain;
(5) with step (3) drying acid grain and step (4) drying alkali grain mix homogeneously completely completely, cross 20 mesh sieve granulate, add the magnesium stearate mix homogeneously of dried particle weight 0.5%, tabletting promptly gets described Fructus Canarii albi effervescent tablet.
The above is merely preferred embodiment of the present invention, and all equalizations of doing according to claim of the present invention change and modify, and all should belong to covering scope of the present invention.
Claims (2)
1. a Fructus Canarii albi effervescent tablet is characterized in that: the raw material of described effervescent tablet and the mass fraction of each raw material: Fructus Canarii albi 2-6 part, Flos Eriobotryae 2-6 part, Herba Pileae Scriptae 1-5 part, Fructus Momordicae 1-3 part.
2. the method for preparing of a Fructus Canarii albi effervescent tablet as claimed in claim 1, it is characterized in that: the concrete steps of described method for preparing are following:
(1) takes by weighing Fructus Canarii albi, Flos Eriobotryae, Herba Pileae Scriptae, Fructus Momordicae by proportioning raw materials, mix and pulverize, add raw material gross weight 1-3 ethanol doubly, under the condition of 35 ℃-55 ℃ of temperature and pressure 30MPa-40MPa, carry out CO
2Supercritical extraction 2 hours-4 hours obtains the Chinese medicine extract;
(2) get the Chinese medicine extract that step (1) obtains, add its weight 1-2 lactose and starch doubly, 60-70 ℃ of dry 2-3h is ground into 180-220 purpose fine powder, is divided into 2 parts, and be subsequent use; The weight ratio of described lactose and starch is 3:2;
(3) getting 1 part of the fine powder that step (2) obtains, add its weight 0.5-1.5 citric acid doubly, is that the starch slurry of 10%-15% is a binding agent with the mass fraction, and 18 orders are granulated, and 50 ℃ of-55 ℃ of dry 1-2h make the acid grain;
(4) getting 1 part of the fine powder that step (2) obtains, add its weight 0.5-1.5 sodium bicarbonate doubly, is that the starch slurry of 10%-15% is a binding agent with the mass fraction, and 18 orders are granulated, and 50 ℃ of-55 ℃ of dry 1-2h make the alkali grain;
(5) with step (3) drying acid grain and step (4) drying alkali grain mix homogeneously completely completely, cross 20 mesh sieve granulate, add the magnesium stearate mix homogeneously of dried particle weight 0.1%-1%, tabletting promptly gets described Fructus Canarii albi effervescent tablet.
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| CN2011103270704A CN102379915A (en) | 2011-10-25 | 2011-10-25 | Olive effervescent tablet and preparation method thereof |
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| CN2011103270704A CN102379915A (en) | 2011-10-25 | 2011-10-25 | Olive effervescent tablet and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989233A (en) * | 2014-04-22 | 2014-08-20 | 安徽省太湖山中药饮片有限公司 | Citron effervescent tablet containing highland barley and preparation method thereof |
| CN104431857A (en) * | 2014-12-26 | 2015-03-25 | 范德和 | Olive lozenge and production process thereof |
| CN106036347A (en) * | 2016-06-11 | 2016-10-26 | 张俊辉 | Processing method of pyracantha fortuneana and hibiscus effervescent tablets |
| CN107137373A (en) * | 2017-05-23 | 2017-09-08 | 西北师范大学 | A kind of Tea Polyphenols effervescent tablet and preparation method thereof |
| CN107308213A (en) * | 2017-06-16 | 2017-11-03 | 山东岐伯堂生物科技有限公司 | A kind of fig effervescent tablet and its production method |
| CN107412373A (en) * | 2017-08-01 | 2017-12-01 | 福建新之源生物制品有限公司 | A kind of loquat leaf extract and preparation method thereof |
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| CN101062102A (en) * | 2007-06-01 | 2007-10-31 | 郑金营 | Material formula of olive microcapsule effervescent tablets and the preparing method thereof |
| CN101366844A (en) * | 2008-09-28 | 2009-02-18 | 成都青山利康药业有限公司 | New use of loquat flower and its extract |
| CN101491585A (en) * | 2008-01-23 | 2009-07-29 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine composite with throat-clearing function and preparation method thereof |
| CN101912113A (en) * | 2010-07-26 | 2010-12-15 | 云南龙润茶业集团有限公司 | Phyllanthus emblica tea effervescent tablet and preparation method thereof |
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2011
- 2011-10-25 CN CN2011103270704A patent/CN102379915A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062102A (en) * | 2007-06-01 | 2007-10-31 | 郑金营 | Material formula of olive microcapsule effervescent tablets and the preparing method thereof |
| CN101491585A (en) * | 2008-01-23 | 2009-07-29 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine composite with throat-clearing function and preparation method thereof |
| CN101366844A (en) * | 2008-09-28 | 2009-02-18 | 成都青山利康药业有限公司 | New use of loquat flower and its extract |
| CN101912113A (en) * | 2010-07-26 | 2010-12-15 | 云南龙润茶业集团有限公司 | Phyllanthus emblica tea effervescent tablet and preparation method thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989233A (en) * | 2014-04-22 | 2014-08-20 | 安徽省太湖山中药饮片有限公司 | Citron effervescent tablet containing highland barley and preparation method thereof |
| CN103989233B (en) * | 2014-04-22 | 2016-01-27 | 安徽省太湖山中药饮片有限公司 | A kind of citron effervescent tablet containing highland barley and preparation method thereof |
| CN104431857A (en) * | 2014-12-26 | 2015-03-25 | 范德和 | Olive lozenge and production process thereof |
| CN106036347A (en) * | 2016-06-11 | 2016-10-26 | 张俊辉 | Processing method of pyracantha fortuneana and hibiscus effervescent tablets |
| CN107137373A (en) * | 2017-05-23 | 2017-09-08 | 西北师范大学 | A kind of Tea Polyphenols effervescent tablet and preparation method thereof |
| CN107308213A (en) * | 2017-06-16 | 2017-11-03 | 山东岐伯堂生物科技有限公司 | A kind of fig effervescent tablet and its production method |
| CN107412373A (en) * | 2017-08-01 | 2017-12-01 | 福建新之源生物制品有限公司 | A kind of loquat leaf extract and preparation method thereof |
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Application publication date: 20120321 |