CN101816714A - Chinese traditional medicine for promoting fracture healing and preparation method thereof - Google Patents
Chinese traditional medicine for promoting fracture healing and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese traditional medicine for promoting fracture healing, which comprises the following components by mass percent: 10-40% of red copper scale, 10-40% of phymatodes lucida, 10-30% of teasel root, 10-30% of sambucus thunbergiana, 5-20% of lycopodium clavatum, 5-20% of phryma leptostachya and 5-20% of radix clematidis. The Chinese traditional medicine preparation for promoting fracture healing is extracted by impregnation, refluxing, percolation, ultrasonic treatment, CO2 subcritical extraction and other methods or is prepared by decoction, filtration, ethanol extraction and other methods. The Chinese traditional medicine preparation can be used for accelerating proliferation of osteoblasts in periosteum and endosteum, restoring periosteal injury and local soft tissue injury and accelerating porosis, thereby achieving the effects of shortening the healing time of fracture patients and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine that promotes union of fracture, belong to biological pharmacy technical field.
Background technology
The healing of fracture is a complex physical, biochemical process, and the influence factor is a lot.Bone is outer, in the inner membrance osteoblast hypertrophy and produce the basis that newborn sclerotin is union of fracture.To could heal fully through the process that hematoma formation, fibroid and osseous callus form and callus is reconstructed after the fracture, make bone on 26S Proteasome Structure and Function, recover normal.
Fracture healing process also is subjected to the influence of several factors except that inherent healing mechanism own:
1. systemic effects
The influence of people's age to union of fracture is significant.The infant union of fracture is very fast, and the teenager union of fracture is easier than the old people, and senile fracture's healing time prolongs.The patient of serious osteoporosis shape or Undernutrition, low albumen, low calcium, shortage VC, shortage VD is arranged, and its union of fracture postpones naturally.If all be unfavorable for union of fracture with serious pulmonary heart disease, diabetes, renal failure.
2. local factor
Blood flow is abundant to be the primary condition of union of fracture.Blood flow difference or blood flow interrupt causing delayed union or disunion, even ischemic necrosis of bone.Big or the local soft tissue major injury of periosteum injury scope will influence union of fracture during fracture.
3. treatment factor
Suitably, reasonably treat meeting promotion union of fracture, otherwise will influence union of fracture, even cause nonunion.
At present the treatment of fractures method mainly is that surgery resets and fixes.Through after well resetting and fixing, traumatic fracture is generally at 3～4 months or cured more than half a year, because convalescent period is longer, fracture patient will be handicapped for a long time, disability even life is rough to take care of oneself.To treatment of fractures, prepare prescription science, the tangible Chinese medicine preparation of drug effect in conjunction with China's traditional medicine, it is the present stage problem demanding prompt solution that the fracture patient healing time is shortened.
Summary of the invention
For solving the problems such as refractory is healed, convalescent period is long of fracturing, and make that bone is outer, osteoblast is accelerated hypertrophy in the inner membrance, periosteum injury and local soft tissue damage are repaired, callus is quickened to form, thereby reach effects such as fracture patient healing time shortening, the invention provides a kind of Chinese medicine that promotes union of fracture and preparation method thereof.
The present invention finishes by following technical proposal: a kind of Chinese medicine that promotes union of fracture is characterized in that being made up of following component by mass percent:
Copper chippings 10～40%
The close net Herba pteridii latiusculi 10～40% of light
Radix Dipsaci 10～30%
Rhizoma seu Herba Elatostematis stewardii 10～30%
Herba Lycopodii 5～20%
Herba speranskiae tuberculatae 5～20%
Radix Clematidis 5～20%.
The invention provides a kind of Chinese medicine that promotes union of fracture, preferably form by following component by mass percent:
Copper chippings 15～25%
The close net Herba pteridii latiusculi 15～25% of light
Radix Dipsaci 10～20%
Rhizoma seu Herba Elatostematis stewardii 10～20%
Herba Lycopodii 7～15%
Herba speranskiae tuberculatae 7～15%
Radix Clematidis 7～15%.
The invention provides a kind of Chinese medicine that promotes union of fracture, preferably form by following component by mass percent:
Copper chippings 20%
The close net Herba pteridii latiusculi 20% of light
Radix Dipsaci 15%
Rhizoma seu Herba Elatostematis stewardii 15%
Herba Lycopodii 10%
Herba speranskiae tuberculatae 10%
Radix Clematidis 10%.
The pharmacological properties of the Chinese medicine that the present invention selects for use is as follows:
1, copper chippings: the copper scale of hitting down when forging copper (Copper chippings.), be strip or fine strip shape, be generally yellowish red color or yellowish-brown, tool metallic luster, body weight and matter are more tough firmly, and depletion of QI is lightly seasoned.Main component is a metallic copper, is subjected to the effect of steam, oxygen, carbon dioxide in air, materials such as the curpic carbonate of the trace that often is being covered on the surface, copper oxide.Nature and flavor are bitter, flat, little poison, GUIXIN, liver, kidney, stomach warp.Cure mainly: synthetism dissipating blood stasis, muscles and bones folding wound, swelling and pain due to blood stasis, traumatic hemorrhage, marginal blepharitis eye, bromhidrosis.
2, the close net Herba pteridii latiusculi of light: be distributed in ground such as Yunnan, Guizhou, Guangxi, Guangdong, be the root stock of fern Polypodiaceae light close net Herba pteridii latiusculi (Phymatodes Lucida (Roxb.) Ching).Exsiccant rhizome is cylindrical, is about 13 centimetres, and toe shape branch is arranged usually, and the surface is a taupe brown, many marks of fibrous root or light brown scale, and matter is hard, and fracture is slightly smooth and be canescence, and vascular bundle is arranged ring formation, and numerous brown points are arranged, and a little less than the feeble QI, it is little puckery to distinguish the flavor of.Nature and flavor are puckery, warm, slightly poisonous.Cure mainly: promoting blood circulation and stopping pain, synthetism detumescence, the kidney invigorating strengthening bone and muscle, traumatic injury, fracture are used as Rhizoma Drynariae in Guangxi.
3, Radix Dipsaci: be the dry root of Dipsacaceae plant Radix Dipsaci (Dipsacus asperoides C.Y.Cheng et T.M.Ai).Excavate autumn, removes root head and fibrous root,, places when treating " diaphoresis " to inner virescence and dry to half-dried with low baking temperature baking.This product is cylindrical, and is slightly flat, the microbend that has, and the surface is taupe or yellowish-brown, and matter is soft, postpone hardening for a long time, frangibility, the section unevenness, skin zone is blackish green or brown, and outer rim is a brown or filbert, and woody part is yellowish-brown, and vessel cluster is radial arrangement.Feeble QI perfume (or spice), bitter in the mouth, little sweet then puckery, nature and flavor are bitter, hot, and tepor is returned liver, kidney channel.Cure mainly: invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered, and ends metrorrhagia.Be used for soreness of the waist and knees, rheumatic arthralgia, the metrorrhagia warp is many, vaginal bleeding during pregnancy hematochezia, injury from falling down.
4, Rhizoma seu Herba Elatostematis stewardii: be dry rhizome or the aerial parts of Caprifoliaceae Sambucus plant Rhizoma seu Herba Elatostematis stewardii (Sambucus chinensis Lindl.), have another name called lotus throne Spica Prunellae, withered, the name Fructus Seu Herba Pubescentis of Mao Yexia.Herb contains compositions such as flavonoid, phenols, tannin, sugared element, seed cyanogenetic glycoside class.Bitter in the mouth, warm in nature, the row twelve channels and collaterals.Cure mainly: dispelling wind and removing obstruction in the collateral, detumescence, pain relieving is invigorated blood circulation in detoxifcation.Be used for traumatic injury, diseases such as rheumatic arthralgia, carbuncle furuncle, edema, rubella.
5, Herba Lycopodii: be the whole herb with root of lycopsid Lycopodium clavatum (Lycopodium japonicum Thunb.ex Murray).This product drying, stolon is elongated and crooked, is yellow or yellow green, matter is pliable and tough, frangibility not, and crust easily comes off, erect stern and branch is arranged, scale leaf often wrinkle and crooked, close being born on the stem, be linear or brill shape, be yellow green or yellow, do not have hair, slightly glossy, end of blade gradually point is aristiform, full edge, vein is not obvious, and, yellow green person long with stem is good.Herb contains alkaloid, acidic materials (account for dry product 0.08%), triterpenoid etc.The bitter in the mouth suffering, temperature, nontoxic, return the liver,spleen,kidney warp.Cure mainly: expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons to promote blood circulation.Be used for anemofrigid-damp arthralgia, joint aches, skin numbness, tetraparesis, traumatic injury.
6, Herba speranskiae tuberculatae: be euphorbia plant speranskia tuberculata (Speranskia tuberculata (Bge.) Baill.) or Balsaminaceae plant Impatientis (Impatiens baslamina L.).Wherein Tuberculate Speranskia Herb is the dry herb that has rhizome of speranskia tuberculata, and Caulis Impatientis is the dry stem of Impatientis.Gather, dry when speranskia tuberculata blossomed and beared fruit between 5～June; Impatientis was gathered during seed maturity summer, autumn, removed withe, dried.Sweet in the mouth, the hot temperature of property, nontoxic.Cure mainly: expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation, pain relieving.Be used for rheumatic arthralgia, muscles and bones contracture, the disturbance of lower legs due to pathogenic cold and dampness, skin ulcer tinea toxic swelling.
7, Radix Clematidis: be the ranunculaceae plant Radix Clematidis, the dry root and rhizome of Clematis hexapetala (C.hexapetala Pall.) or northeast clematis (C.manshurica Rupr.).Medical material is even with the root bar, the black meat of skin is white, and matter is solid, the residual stem person in nothing ground is good.The property suffering is salty, and temperature is poisonous, goes into urinary bladder channel.Function cures mainly: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the hypochondriac lump of loosing.Be used for rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, tetanus, tonsillitis.
Another object of the present invention is to provide a kind of preparation method of Chinese medicine that promotes union of fracture, the following processing step of process:
A1. get material by following mass percent:
Copper chippings 10～40%
The close net Herba pteridii latiusculi 10～40% of light
Radix Dipsaci 10～30%
Rhizoma seu Herba Elatostematis stewardii 10～30%
Herba Lycopodii 5～20%
Herba speranskiae tuberculatae 5～20%
Radix Clematidis 5～20%
A2. above-mentioned each medical material is cleaned, and be ground into powder;
A3. make the Chinese medicine preparation that promotes union of fracture routinely.
The invention provides a kind of preparation method of Chinese medicine that promotes union of fracture, pass through following process steps:
B. get material by following mass percent:
Copper chippings 10～40%
The close net Herba pteridii latiusculi 10～40% of light
Radix Dipsaci 10～30%
Rhizoma seu Herba Elatostematis stewardii 10～30%
Herba Lycopodii 5～20%
Herba speranskiae tuberculatae 5～20%
Radix Clematidis 5～20%
B1. decoct each medical material with solvent, and carry out conventional dipping, backflow, diafiltration, ultrasonic Treatment, CO
2Subcritical abstraction;
B2. make the Chinese medicine preparation that promotes union of fracture routinely.
Solvent in the described B1 step is that water, mass concentration are a kind of in 30～100% ethanol, methanol, the chloroform.
Dipping, backflow, diafiltration, ultrasonic Treatment, CO in the described B2 step
2Subcritical abstraction is conventional extracting method.
The invention provides a kind of preparation method of Chinese medicine that promotes union of fracture, pass through following process steps:
C. get material by following mass percent:
Copper chippings 10～40%
The close net Herba pteridii latiusculi 10～40% of light
Radix Dipsaci 10～30%
Rhizoma seu Herba Elatostematis stewardii 10～30%
Herba Lycopodii 5～20%
Herba speranskiae tuberculatae 5～20%
Radix Clematidis 5～20%;
C1. it is standby copper chippings to be ground into fine powder;
C2. C1 gained powder is mixed with the close net Herba pteridii latiusculi of light, Herba Lycopodii, Herba speranskiae tuberculatae, 8～15 times the decocting that adds mixture quality boiled 1～3 hour, filtered to get filtrate and filtering residue;
C3. in C2 in the gained filtering residue, 8～15 times the decocting that adds the filtering residue quality again boiled 1～3 hour, filter, filtrate and filtering residue, gained filtrate merging among filtrate and the C2;
C4. the filtrate with C3 is condensed into paste, adds mass concentration and is 95% alcoholic solution and reach 60～90% mass ratio, standing over night to containing the alcohol amount;
C5. with the supernatant distilling under reduced pressure of C4, it is standby to obtain extractum;
C6. Radix Dipsaci, Rhizoma seu Herba Elatostematis stewardii, Radix Clematidis are mixed, 4～10 times the concentration that adds three's mixing quality is 60～90% alcoholic solution, in 60～80 ℃ of hot refluxs 1～3 hour, filters to get filtrate and filtering residue;
C7. 4～10 times the concentration that adds the filtering residue quality in the filtering residue of C6 again is 60～90% alcoholic solution, extracts 1～3 hour in 60～80 ℃ of hot refluxs, filters to get filtrate and filtering residue;
C8. gained filtrate among C6 and the C7 is merged, through distilling under reduced pressure, it is standby to obtain extractum;
C9. with step C5 and C8 gained extractum mix homogeneously, after drying, make the Chinese medicine preparation that promotes union of fracture.
Described Chinese medicine preparation is made pharmaceutically acceptable any preparation, as conventional formulations such as tablet, capsule, granule, ointment, pills for add an amount of pharmaceutic adjuvant in the former medicine that is ground into the end.
Described Chinese medicine preparation is the utilization conventional method, and adds proper quantity of medicinal auxiliary material in extractum, makes pharmaceutically acceptable any preparation, as conventional formulations such as tablet, capsule, soft capsule, granule, ointment, pill, tinctures.
Described Chinese medicine preparation is made medicine-containing particle with conventional wet granulation technique with extractum, further is prepared into dosage forms such as granule, tablet, pill, capsule, drop pill again.
Described Chinese medicine preparation is made dried cream with methods such as conventional spray drying, drying under reduced pressure, fluid bed dryings with extractum, is ground into last adding appropriate amount of auxiliary materials and makes medicine-containing particle, further is prepared into dosage forms such as granule, tablet or capsule again.
Described Chinese medicine preparation dilutes extractum with conventional method with 50～95% dissolve with ethanol solutions, be prepared into tincture.
Described Chinese medicine preparation is heated to 60～100 ℃ with conventional method with extractum, and other gets the ointment base heating and melting, slowly joins in the hot dipping cream, and stirring is prepared into ointment.
Described Chinese medicine preparation joins extractum in the drop pill substrate that has heated with conventional method, does not stop to stir to make its whole fusions, splashes into while hot in the liquid coolant, is condensed into drop pill.
The Chinese medicine of promotion union of fracture provided by the invention has effects such as promoting growth of spur, ecchymosis disappear and take off, reducing swelling and alleviating pain.No obvious adverse reaction for oral administration, external is non-stimulated to skin, do not have irritated phenomenon.The present invention utilizes the prescription theory and the Therapeutic Principle of traditional Chinese medicine, reasonable formula, and it is few that effective ingredient is run off, and the bioavailability height promotes the fracture site healing acceleration with pure Chinese medicine, has characteristics such as safety, convenience, determined curative effect.According to demand, can conventional method be prepared into dosage forms such as capsule, tablet, granule, drop pill, tincture, ointment, easy to use.
The specific embodiment
Below in conjunction with embodiment the present invention is described further.
Embodiment 1
A1. get material by following mass component: copper chippings 30g, the close net Herba pteridii latiusculi 10g of light, Radix Dipsaci 15g, Rhizoma seu Herba Elatostematis stewardii 15g, Herba Lycopodii 15g, Herba speranskiae tuberculatae 5g, Radix Clematidis 10g;
A11. above-mentioned each medical material is cleaned, and be ground into powder;
A12. add an amount of pharmaceutic adjuvant routinely and make the capsule that promotes union of fracture.
Embodiment 2
A2. get material by following mass component: copper chippings 10g, the close net Herba pteridii latiusculi 25g of light, Radix Dipsaci 30g, Rhizoma seu Herba Elatostematis stewardii 10g, Herba Lycopodii 5g, Herba speranskiae tuberculatae 15g, Radix Clematidis 5g;
A21. above-mentioned each medical material is cleaned, and be ground into powder;
A22. add an amount of pharmaceutic adjuvant routinely and make the tablet that promotes union of fracture.
Embodiment 3
A3. get material by following mass component: copper chippings 15g, the close net Herba pteridii latiusculi 15g of light, Radix Dipsaci 20g, Rhizoma seu Herba Elatostematis stewardii 20g, Herba Lycopodii 10g, Herba speranskiae tuberculatae 5g, Radix Clematidis 15g;
A31. above-mentioned each medical material is cleaned, and be ground into powder;
A32. add an amount of pharmaceutic adjuvant routinely and make the pill that promotes union of fracture.
Embodiment 4
B1. get material by following mass component: copper chippings 25g, the close net Herba pteridii latiusculi 10g of light, Radix Dipsaci 10g, Rhizoma seu Herba Elatostematis stewardii 30g, Herba Lycopodii 15g, Herba speranskiae tuberculatae 5g, Radix Clematidis 5g;
B11. water decocts each medical material, and flood, backflow, diafiltration, ultrasonic Treatment, CO
2Subcritical abstraction;
B12. add an amount of pharmaceutic adjuvant routinely and make the granule that promotes union of fracture.
Embodiment 5
B2. get material by following mass component: copper chippings 40g, the close net Herba pteridii latiusculi 10g of light, Radix Dipsaci 10g, Rhizoma seu Herba Elatostematis stewardii 10g, Herba Lycopodii 20g, Herba speranskiae tuberculatae 5g, Radix Clematidis 5g;
B21. be that 30% ethanol decocts each medical material with concentration, and flood, backflow, diafiltration, ultrasonic Treatment, CO
2Subcritical abstraction;
B22. add an amount of pharmaceutic adjuvant routinely and make the tincture that promotes union of fracture.
Embodiment 6
B3. get material by following mass component: copper chippings 30g, the close net Herba pteridii latiusculi 30g of light, Radix Dipsaci 15g, Rhizoma seu Herba Elatostematis stewardii 10g, Herba Lycopodii 5g, Herba speranskiae tuberculatae 5g, Radix Clematidis 5g;
B31. decoct each medical material with methanol, and flood, backflow, diafiltration, ultrasonic Treatment, CO
2Subcritical abstraction;
B32. add an amount of pharmaceutic adjuvant routinely and make the drop pill that promotes union of fracture.
Embodiment 7
B4. get material by following mass component: copper chippings 20g, the close net Herba pteridii latiusculi 40g of light, Radix Dipsaci 10g, Rhizoma seu Herba Elatostematis stewardii 15g, Herba Lycopodii 5g, Herba speranskiae tuberculatae 5g, Radix Clematidis 5g;
B41. be that 75% ethanol decocts each medical material with concentration, and flood, backflow, diafiltration, ultrasonic Treatment, CO
2Subcritical abstraction;
B42. add an amount of pharmaceutic adjuvant routinely and make the soft capsule that promotes union of fracture.
Embodiment 8
B5. get material by following mass component: copper chippings 20g, the close net Herba pteridii latiusculi 20g of light, Radix Dipsaci 10g, Rhizoma seu Herba Elatostematis stewardii 10g, Herba Lycopodii 10g, Herba speranskiae tuberculatae 10g, Radix Clematidis 20g;
B51. decoct each medical material with chloroform, and flood, backflow, diafiltration, ultrasonic Treatment, CO
2Subcritical abstraction;
B52. add an amount of pharmaceutic adjuvant routinely and make the capsule that promotes union of fracture.
Embodiment 9
B6. get material by following mass component: copper chippings 30g, the close net Herba pteridii latiusculi 15g of light, Radix Dipsaci 15g, Rhizoma seu Herba Elatostematis stewardii 10g, Herba Lycopodii 5g, Herba speranskiae tuberculatae 20g, Radix Clematidis 5g;
B61. be that 100% ethanol decocts each medical material with concentration, and flood, backflow, diafiltration, ultrasonic Treatment, CO
2Subcritical abstraction;
B62. add an amount of pharmaceutic adjuvant routinely and make the ointment that promotes union of fracture.
Embodiment 10
A. get material by following mass component: copper chippings 25g, the close net Herba pteridii latiusculi 25g of light, Radix Dipsaci 10g, Rhizoma seu Herba Elatostematis stewardii 10g, Herba Lycopodii 5g, Herba speranskiae tuberculatae 5g, Radix Clematidis 20g;
B. it is standby copper chippings to be ground into fine powder;
C. the decocting that B gained powder and the close net of light Herba pteridii latiusculi, Herba Lycopodii, Herba speranskiae tuberculatae is added jointly quality and be 8 times boiled 2 hours, filtered;
D. the decocting that gained filtering residue among the C is added quality again and be 10 times boiled 3 hours, filtered gained filtrate merging among filtrate and the C;
E. filtrate is condensed into paste, adding concentration is 95% alcoholic solution, reaches 60% mass percent, standing over night to containing the alcohol amount;
F. extract supernatant, through distilling under reduced pressure, reclaim ethanol, it is standby to obtain extractum;
G. the concentration that with adding quality in Radix Dipsaci, Rhizoma seu Herba Elatostematis stewardii, the Radix Clematidis is 10 times is 60% alcoholic solution, in 80 ℃ of hot refluxs 1 hour, filters;
H. to add quality again be that 7 times concentration is 80% alcoholic solution to filtering residue, extracted 2 hours in 70 ℃ of hot refluxs, filters;
I. gained filtrate among G and the H is merged, through distilling under reduced pressure, reclaim ethanol, it is standby to obtain extractum;
J. with gained extractum mix homogeneously among step F and the I, add an amount of pharmaceutic adjuvant routinely and make the spray that promotes union of fracture.
Embodiment 11
A. get material by following mass component: copper chippings 20g, the close net Herba pteridii latiusculi 20g of light, Radix Dipsaci 15g, Rhizoma seu Herba Elatostematis stewardii 15g, Herba Lycopodii 10g, Herba speranskiae tuberculatae 10g, Radix Clematidis 10g;
B. it is standby copper chippings to be ground into fine powder;
C. the decocting that B gained powder and the close net of light Herba pteridii latiusculi, Herba Lycopodii, Herba speranskiae tuberculatae is added jointly quality and be 15 times boiled 3 hours, filtered;
D. the decocting that gained filtering residue among the C is added quality again and be 8 times boiled 1 hour, filtered gained filtrate merging among filtrate and the C;
E. filtrate is condensed into paste, adding concentration is 95% alcoholic solution, reaches 90% mass percent, standing over night to containing the alcohol amount;
F. extract supernatant, through distilling under reduced pressure, reclaim ethanol, it is standby to obtain extractum;
G. the concentration that with adding quality in Radix Dipsaci, Rhizoma seu Herba Elatostematis stewardii, the Radix Clematidis is 8 times is 80% alcoholic solution, in 70 ℃ of hot refluxs 2 hours, filters;
H. to add quality again be that 4 times concentration is 90% alcoholic solution to filtering residue, extracted 3 hours in 60 ℃ of hot refluxs, filters;
I. gained filtrate among G and the H is merged, through distilling under reduced pressure, reclaim ethanol, it is standby to obtain extractum;
J. with gained extractum mix homogeneously among step F and the I, add an amount of pharmaceutic adjuvant routinely and make the ointment that promotes union of fracture.
Embodiment 12
A. get material by following mass component: copper chippings 10g, the close net Herba pteridii latiusculi 40g of light, Radix Dipsaci 10g, Rhizoma seu Herba Elatostematis stewardii 10g, Herba Lycopodii 5g, Herba speranskiae tuberculatae 20g, Radix Clematidis 5g;
B. it is standby copper chippings to be ground into fine powder;
C. the decocting that B gained powder and the close net of light Herba pteridii latiusculi, Herba Lycopodii, Herba speranskiae tuberculatae is added jointly quality and be 12 times boiled 1 hour, filtered;
D. the decocting that gained filtering residue among the C is added quality again and be 15 times boiled 2 hours, filtered gained filtrate merging among filtrate and the C;
E. filtrate is condensed into paste, adding concentration is 95% alcoholic solution, reaches 70% mass percent, standing over night to containing the alcohol amount;
F. extract supernatant, through distilling under reduced pressure, reclaim ethanol, it is standby to obtain extractum;
G. the concentration that with adding quality in Radix Dipsaci, Rhizoma seu Herba Elatostematis stewardii, the Radix Clematidis is 4 times is 90% alcoholic solution, in 60 ℃ of hot refluxs 3 hours, filters;
H. to add quality again be that 10 times concentration is 60% alcoholic solution to filtering residue, extracted 1 hour in 80 ℃ of hot refluxs, filters;
I. gained filtrate among G and the H is merged, through distilling under reduced pressure, reclaim ethanol, it is standby to obtain extractum;
J. with gained extractum mix homogeneously among step F and the I, add an amount of pharmaceutic adjuvant routinely and make the liniment that promotes union of fracture.
The present invention will be described below by zoopery.
Carry out zoopery with the foregoing description 11 gained ointments, its result is reported as follows:
1 materials and methods
1.1 40 of healthy hybrid rabbits, be male, 2～2.5 kilograms of body weight.Experimentize after one month with identical forage feed.
1.2 medicine
Getting the present invention, to make ointment standby.
1.3 method
At random each 20 of the hybrid rabbits of participating in the experiment are divided into treatment group and matched group.Right side main drive operation is the treatment group, and main drive operation in left side is matched group.The hybrid rabbit is carried out auricular vein anesthesia with 3% pentobarbital sodium (300mg/kg), in the cropping of bilateral forearm, iodine tincture ethanol routine disinfection, under aseptic condition, pass through operation method, with dental drill that last 1/3 place in all rabbit left fore radius is sawed-off, cause three millimeters cross-section damaged, postoperative is not done any fixing.(4 * 10U/kg), logotype 3 days is in case the local wound infection for postoperative intramuscular injection every day penicillin.
Treatment is organized in operation back beginning in the 3rd day Traditional Chinese Medicine for external application, and its method is that standby ointment is evenly coated on the antiseptic gauze, directly is wrapped on the right side limb of shaving hair, and the immobilization with adhesive tape of external gauze was changed dressings SM 1 time in per two days.The not drug of topical application of matched group.
The single cage of animal is raised.2,4,6,8 weeks of postoperative adopt the air tap inserting method to put to death 5 of animals with every group as the time point of observation at each time point of observation.The side limb that taking-up is had an operation is rejected the soft tissue on the radius, with the transverse diameter of vernier caliper measurement callus, calculates cross-sectional area.The laboratory animal in 4 weeks of postoperative places the dynamometry controller to measure the radius fracture resistence force radius behind the transverse diameter of measuring callus.
2 results
2.1 medicine is to the influence (seeing Table 1) of callus cross-sectional area
The oriental cherry sectional area measurement result S/mm of table 1 callus
2
The result shows that the callus cross-sectional area of fracture back 6 all innerlich anwenden groups is greater than matched group.Illustrate that the ointment of using the embodiment of the invention 1 can promote the growth of callus.
2.2 postoperative 4 all fracture resistence force measuring results (seeing Table 2)
The 4 all radius fracture resistence force experiment quantitative analyses of table 2 postoperative
The measurement result of radius fracture resistence force experiment has proved that ointment of the present invention can improve fractures callus quality by the biological property that strengthens fracture resistence force.
Claims (3)
1. Chinese medicine that promotes union of fracture is characterized in that being made up of following component by mass percent:
Copper chippings 10～40%
The close net Herba pteridii latiusculi 10～40% of light
Radix Dipsaci 10～30%
Rhizoma seu Herba Elatostematis stewardii 10～30%
Herba Lycopodii 5～20%
Herba speranskiae tuberculatae 5～20%
Radix Clematidis 5～20%.
2. one kind prepares the method that promotes union of fracture Chinese medicine according to claim 1, it is characterized in that through following processing step:
A. get material by following mass percent:
Copper chippings 10～40%
The close net Herba pteridii latiusculi 10～40% of light
Radix Dipsaci 10～30%
Rhizoma seu Herba Elatostematis stewardii 10～30%
Herba Lycopodii 5～20%
Herba speranskiae tuberculatae 5～20%
Radix Clematidis 5～20%
A1. above-mentioned each medical material is cleaned, and be ground into powder;
A2. make the Chinese medicine preparation that promotes union of fracture after to be dried;
Perhaps pass through following each processing step:
B. get material by following mass percent:
Copper chippings 10～40%
The close net Herba pteridii latiusculi 10～40% of light
Radix Dipsaci 10～30%
Rhizoma seu Herba Elatostematis stewardii 10～30%
Herba Lycopodii 5～20%
Herba speranskiae tuberculatae 5～20%
Radix Clematidis 5～20%
B1. decoct each medical material with solvent, and flood, backflow, diafiltration, ultrasonic Treatment, CO
2Subcritical abstraction;
B2. make the Chinese medicine preparation that promotes union of fracture after to be dried;
Perhaps pass through following each processing step:
C. get material by following mass percent:
Copper chippings 10～40%
The close net Herba pteridii latiusculi 10～40% of light
Radix Dipsaci 10～30%
Rhizoma seu Herba Elatostematis stewardii 10～30%
Herba Lycopodii 5～20%
Herba speranskiae tuberculatae 5～20%
Radix Clematidis 5～20%;
C1. it is standby copper chippings to be ground into fine powder;
C2. C1 gained powder is mixed with the close net Herba pteridii latiusculi of light, Herba Lycopodii, Herba speranskiae tuberculatae, 8～15 times the decocting that adds mixture quality boiled 1～3 hour, filtered to get filtrate and filtering residue;
C3. in C2 gained filtering residue, 8～15 times the decocting that adds the filtering residue quality again boiled 1～3 hour, filtered, and gained filtrate merges among filtrate and the C2;
C4. filtrate is condensed into paste, adding concentration is 95% alcoholic solution, reaches 60～90% mass percent, standing over night to containing the alcohol amount;
C5. with the supernatant distilling under reduced pressure, it is standby to obtain extractum;
C6. Radix Dipsaci, Rhizoma seu Herba Elatostematis stewardii, Radix Clematidis are mixed, 4～10 times the concentration that adds three's mixing quality is 60～90% alcoholic solution, in 60～80 ℃ of hot refluxs 1～3 hour, filters to get filtrate and filtering residue;
C7. 4～10 times the concentration that adds the filtering residue quality in the filtering residue again is 60～90% alcoholic solution, extracts 1～3 hour in 60～80 ℃ of hot refluxs, filters;
C8. gained filtrate among C6 and the C7 is merged, through distilling under reduced pressure, it is standby to obtain extractum;
C9. with gained extractum mix homogeneously among step C5 and the C8, make the Chinese medicine preparation that promotes union of fracture after drying.
3. preparation method according to claim 2 is characterized in that: the solvent in the described B1 step is that water, mass concentration are a kind of in 30～100% ethanol, methanol or the chloroform.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010159745.4A CN101816714A (en) | 2010-04-29 | 2010-04-29 | Chinese traditional medicine for promoting fracture healing and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010159745.4A CN101816714A (en) | 2010-04-29 | 2010-04-29 | Chinese traditional medicine for promoting fracture healing and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474000A (en) * | 2014-12-01 | 2015-04-01 | 马喜超 | Traditional Chinese medicine for setting fracture and preparation method thereof |
| CN103494973B (en) * | 2013-09-24 | 2016-03-30 | 王祝民 | For the Chinese medicine decoction of bone healing |
| CN105943930A (en) * | 2016-06-30 | 2016-09-21 | 庄园 | Traditional Chinese medicine for treating fracture and preparation method of traditional Chinese medicine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071843A (en) * | 1992-12-18 | 1993-05-12 | 柳海峰 | The preparation method of " three-flower " bone-knitting powder |
-
2010
- 2010-04-29 CN CN201010159745.4A patent/CN101816714A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071843A (en) * | 1992-12-18 | 1993-05-12 | 柳海峰 | The preparation method of " three-flower " bone-knitting powder |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494973B (en) * | 2013-09-24 | 2016-03-30 | 王祝民 | For the Chinese medicine decoction of bone healing |
| CN104474000A (en) * | 2014-12-01 | 2015-04-01 | 马喜超 | Traditional Chinese medicine for setting fracture and preparation method thereof |
| CN105943930A (en) * | 2016-06-30 | 2016-09-21 | 庄园 | Traditional Chinese medicine for treating fracture and preparation method of traditional Chinese medicine |
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Application publication date: 20100901 |