CN1071843A - The preparation method of " three-flower " bone-knitting powder - Google Patents
The preparation method of " three-flower " bone-knitting powder Download PDFInfo
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- CN1071843A CN1071843A CN92114507A CN92114507A CN1071843A CN 1071843 A CN1071843 A CN 1071843A CN 92114507 A CN92114507 A CN 92114507A CN 92114507 A CN92114507 A CN 92114507A CN 1071843 A CN1071843 A CN 1071843A
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- radix
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- radix angelicae
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Abstract
A kind of preparation method of impelling rapid healing of fracture bone knitting powder (" three-flower " bone-knitting powder) for oral administration adopts Radix Notoginseng, Stigma Croci, Semen Strychni, Cortex cinnamomi japonici (Ramulus Cinnamomi), Lignum Aquilariae Resinatum, Radix Angelicae Sinensis, Pheretima, Radix Achyranthis Bidentatae, Borneolum Syntheticum, the Radix Aucklandiae, Rhizoma Chuanxiong, Eupolyphaga Seu Steleophaga, Radix Dipsaci, Rhizoma Drynariae, Sanguis Draxonis, Radix Et Rhizoma Rhei, Pyritum and Radix Angelicae Dahuricae crushing screening to mix.Bright the shifting to an earlier date of clinical 96 illustrations made fracture person's union of fracture in 2-3 weeks.
Description
The present invention relates to a kind of preparation method of impelling the bone knitting powder of rapid healing of fracture for oral administration, particularly adopt the preparation method of the bone knitting powder for oral administration of Chinese herbal medicine.
Mostly adopt external application for fracture, traumatic injury, swelling and pain due to blood stasis, sprain etc. in the prior art, particularly for fracture, then many employing external applications add fixation, make its fracture normal healing, and the shortcoming of this method is that healing time is oversize.Tongrentang Pharmaceutical Factory, Beijing's " Anisodus carniolicoides C.Y.Wu et C.Chen " of producing occurs in recent years, though for fracture the healing of promotion effect is arranged, but still exist the oversize shortcoming of healing time.
The object of the present invention is to provide a kind of preparation method of forming by Chinese herbal medicine that can make the bone knitting powder for oral administration of union of fracture more effective than existing oral medicine, fast.
The present invention implements like this, adopts 18 flavor medical materials, and is wherein based on Radix Notoginseng and Stigma Croci, so the medicine name of bone knitting powder of the present invention is called " " three-flower " bone-knitting powder ", existing as follows to the function description of following 18 flavor medical materials according to Chinese Pharmacopoeia (1990):
(1) Radix Notoginseng: can stop blooding subduing swelling and relieving pain by dissipating blood stasis.
(2) Stigma Croci: can circulation of qi promoting and blood.
(3) Pyritum: dissipating blood stasis, bone-setting pain stopping effect are arranged.
(4) Semen Strychni: the diffusing blood knot pain relieving of stimulating the menstrual flow, disappear
(5) Ramulus Cinnamomi: warming the meridian and promoting blood circulation, clearing away damp-heat, reducing swelling and alleviating pain.
(6) Lignum Aquilariae Resinatum: walk the pain relieving of serial gas.
(7) Radix Angelicae Sinensis: circulation of qi promoting and blood.
(8) Pheretima: warming the meridian and promoting blood circulation, reducing swelling and alleviating pain.
(9) Radix Achyranthis Bidentatae: invigorating the liver and kidney, strengthing aitch bone, drive that the stasis of blood is stimulated the menstrual flow, conducting blood to flow downwards.
(10) Borneolum Syntheticum: promoting the circulation of QI to relieve pain.
(11) Radix Aucklandiae: detumescence, pain relieving, promoting of the circulation of QI and removing the obstruction in the collaterals.
(12) Rhizoma Chuanxiong: circulation of qi promoting, pain relieving, detumescence.
(13) Eupolyphaga Seu Steleophaga: removing blood stasis with potent drugs blood, reunion of fractured tendons and bones.
(14) Radix Dipsaci: detumescence, dissipating blood stasis, synthetism.
(15) Rhizoma Drynariae: promoting the circulation of QI to relieve pain, draw the institute that all medicines reach the disease wound.
(16) Sanguis Draxonis: the diffusing blood knot pain relieving of stimulating the menstrual flow, disappear.
(17) Radix Et Rhizoma Rhei: warming the meridian and promoting blood circulation, warm clearly, reducing swelling and alleviating pain.
(18) Radix Angelicae Dahuricae: walk serial gas, reducing swelling and alleviating pain.
The proportioning (by weight) of bone knitting powder of the present invention (the being " three-flower " bone-knitting powder) medical material of respectively distinguishing the flavor of is as follows: Radix Notoginseng (24-28), Stigma Croci (40-48), Semen Strychni (25-30), Ramulus Cinnamomi (85-95), Lignum Aquilariae Resinatum (40-48), Radix Angelicae Sinensis (85-95), Pheretima (42-48), Radix Achyranthis Bidentatae (32-38), Borneolum Syntheticum (24-30), the Radix Aucklandiae (32-38), Rhizoma Chuanxiong (85-95), Eupolyphaga Seu Steleophaga (85-95), Radix Dipsaci (85-95), Rhizoma Drynariae (42-48), Sanguis Draxonis (138-145), Radix Et Rhizoma Rhei (15-20), Pyritum (32-38), the Radix Angelicae Dahuricae (32-38).
Preparation method of the present invention is as follows:
(1) get Radix Et Rhizoma Rhei, Radix Achyranthis Bidentatae, Radix Dipsaci, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Pheretima, Ramulus Cinnamomi, Rhizoma Drynariae, eight flavor medicines, each comfortable 60-80 ℃ down oven dry pulverized 100 mesh sieves in natural cooling and each the comfortable pulverizer after 4 hours.
(2) get the Radix Aucklandiae, Rhizoma Chuanxiong, Lignum Aquilariae Resinatum, Stigma Croci, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis Six-element medicine and after 40-50 ℃ dries 6 hours down, pulverized 100 mesh sieves in each comfortable pulverizer of natural cooling separately.
(3) will pulverize 100 mesh sieves in Sanguis Draxonis, Pyritum, Lignum Aquilariae Resinatum, Borneolum Syntheticum, each comfortable pulverizer respectively.
(4) mix: the medicated powder mix homogeneously and become bone knitting powder of the present invention in having agitator of will above-mentioned 18 distinguishing the flavor of.
Following preference elaborates to the present invention, but does not limit the scope of the invention.
Example 1:(1) takes by weighing Radix Et Rhizoma Rhei 17 gram, Radix Achyranthis Bidentatae 33 grams, Radix Dipsaci 87 grams, ground beetle 87 grams, Radix Notoginseng 25 grams, Pheretima 44 grams, Ramulus Cinnamomi 87 grams, Rhizoma Drynariae 44 grams, each comfortable 70 ℃ of oven dry 4 hours down respectively.In general pulverizer, pulverize separately behind the natural cooling.Cross 100 mesh sieves then, each get powder.
(2) take by weighing each the comfortable 45 ℃ of oven dry 6 hours down of the Radix Aucklandiae 34 gram, Rhizoma Chuanxiong 87 grams, the Radix Angelicae Dahuricae 34 grams, Radix Angelicae Sinensis 87 grams, Lignum Aquilariae Resinatum 42 grams and Stigma Croci 42 grams respectively, in general pulverizer, pulverize separately behind the natural cooling, cross 100 mesh sieves then, each get powder.
(3) each get powder with pulverizing and cross 100 mesh sieves in Sanguis Draxonis 140 grams, Pyritum 34 grams, Lignum Aquilariae Resinatum 42 grams and the broken machine of Borneolum Syntheticum 26 each comfortable all purpose flour of gram respectively.
(4) with above-mentioned 18 flavor medicated powder ends, mix homogeneously in having the multimixer of agitator and become bone knitting powder of the present invention (1).
Example 2: the consumption that removes each flavor medicine becomes Radix Et Rhizoma Rhei 20 grams, Radix Achyranthis Bidentatae 37 grams, Radix Dipsaci 94 grams, Eupolyphaga Seu Steleophaga 94 grams, Radix Notoginseng 27 grams, Pheretima 47 grams, Ramulus Cinnamomi 94 grams, Rhizoma Drynariae 48 grams, the Radix Aucklandiae 38 grams, Rhizoma Chuanxiong 94 grams, XUEZHI 37 grams.Outside Radix Angelicae Sinensis 94 grams, Lignum Aquilariae Resinatum 47 grams, Stigma Croci 48 grams, Sanguis Draxonis 144 grams, Pyritum 37 grams, Lignum Aquilariae Resinatum 47 grams and Borneolum Syntheticum 30 grams, all the other conditions are identical with example 1, make bone knitting powder of the present invention (2).
Example 3: be to Os Canitis folding healing test
Get 42 of 6 months sizes, 7.5 ± 1.52 kilograms of dogs of body weight, be divided into 7 groups at random, every group of 6 male and female half and half, with cause identical fracture with quadrat method, the result can find out that bone knitting powder of the present invention obviously is better than Anisodus carniolicoides C.Y.Wu et C.Chen, effect with quick promotion union of fracture illustrates that also bone knitting powder of the present invention (1) and (2) are (the seeing the following form) with same effect simultaneously.
Example 4: for the clinical trial of human body, treated 96 examples, existing 1 example of only lifting
The Wang: the man, 45 years old, intertrochanteric fracture of the femur was taken bone knitting powder of the present invention and can be seen a large amount of growth of spur after 4 weeks.
Comparative Examples 1: Zhang: the man, 40 years old, intertrochanteric fracture of the femur adopted just see growth of spur traditional 7 weeks of traction therapy of bone.
Powdered medicine for coaptation preparation method's of the present invention advantage is as follows:
(1) 18 kind of medicine all is the Chinese medicine that is easy to get commonly used.
(2) method for making is simple, and the drier of employing, pulverizer and blender all are common apparatus.
(3) under lower baking temperature, carry out drying.
(4) it is very simple and convenient to take powdered medicine for coaptation of the present invention, and the union effect is remarkable.
| The dosage number of animals supports and lands the time | |
| (powdered medicine for coaptation＜1 〉) the present invention (powdered medicine for coaptation＜2 〉) (¨) | (g/Kg) (only) (my god) 0.800 6 5.50 ± 0.54 0.400 6 5.60 ± 0.54 0.100 6 7.33 ± 1.21 |
| Tongrentang's Qili San | 0.240 6 7.30±2.16 0.120 6 7.16±0.75 0.030 6 8.30±0.52 |
| Blank | 6 8.00±0.00 |
Claims (2)
1, a kind of preparation method of impelling the rapid healing of fracture bone knitting powder for oral administration is characterized in that:
(1) adopts following 18 kinds of Chinese crude drugs, i.e. Radix Notoginseng, Stigma Croci, Semen Strychni, Ramulus Cinnamomi, Lignum Aquilariae Resinatum, Radix Angelicae Sinensis, Pheretima, Radix Achyranthis Bidentatae, Borneolum Syntheticum, the Radix Aucklandiae, Rhizoma Chuanxiong, Eupolyphaga Seu Steleophaga, Radix Dipsaci, Rhizoma Drynariae, Sanguis Draxonis, Radix Et Rhizoma Rhei, Pyritum, the Radix Angelicae Dahuricae.
(2) Radix Et Rhizoma Rhei, Radix Achyranthis Bidentatae, Radix Dipsaci, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Pheretima, Cortex cinnamomi japonici (Ramulus Cinnamomi), Rhizoma Drynariae be under 60-80 ℃, carry out exsiccant.
(3) Radix Aucklandiae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Lignum Aquilariae Resinatum, Stigma Croci be under 40-50 ℃, carry out exsiccant.
(4) the direct crushing screening of Sanguis Draxonis, Pyritum, Lignum Aquilariae Resinatum and Borneolum Syntheticum.
2, preparation method according to claim 1 is characterized in that: the proportioning of described 18 kinds of medicines (by weight) is a Radix Notoginseng (24-28), Stigma Croci (40-48), Semen Strychni 25-30), Ramulus Cinnamomi (85-95), Lignum Aquilariae Resinatum (40-48), Radix Angelicae Sinensis (85-95), Pheretima (42-48), Radix Achyranthis Bidentatae (32-38), Borneolum Syntheticum (24-30), the Radix Aucklandiae (32-38), Rhizoma Chuanxiong (85-95), Eupolyphaga Seu Steleophaga (85-95), Radix Dipsaci (85-95), Rhizoma Drynariae (42-48), Sanguis Draxonis (138-145), Radix Et Rhizoma Rhei (15-20), Pyritum (32-38), the Radix Angelicae Dahuricae (32-38).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92114507A CN1035717C (en) | 1992-12-18 | 1992-12-18 | Method for preparing "three-flower" bone-knitting powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92114507A CN1035717C (en) | 1992-12-18 | 1992-12-18 | Method for preparing "three-flower" bone-knitting powder |
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| Publication Number | Publication Date |
|---|---|
| CN1071843A true CN1071843A (en) | 1993-05-12 |
| CN1035717C CN1035717C (en) | 1997-08-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92114507A Expired - Fee Related CN1035717C (en) | 1992-12-18 | 1992-12-18 | Method for preparing "three-flower" bone-knitting powder |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1044685C (en) * | 1993-07-21 | 1999-08-18 | 陈俊如 | Traditional Chinese medicine for treating bone fracture |
| CN1054295C (en) * | 1995-05-19 | 2000-07-12 | 张治国 | Patent drug- "jiegu" powder medicine for treatment of fracture |
| CN1059096C (en) * | 1996-01-05 | 2000-12-06 | 李振 | Method of preparing medicated wine for treating injury and setting bone |
| CN1060387C (en) * | 1997-07-31 | 2001-01-10 | 包学仁 | Bone-knitting pill and producing process thereof |
| CN1069037C (en) * | 1995-04-05 | 2001-08-01 | 唐兴华 | Method for preparing oral capsule for treating difficult and complicated fracture |
| KR100330924B1 (en) * | 1996-12-05 | 2002-10-04 | 주식회사 엘지씨아이 | Oral composition containing extract of ulmi cortex for treatment of periodontal diseases |
| CN1292768C (en) * | 2001-02-22 | 2007-01-03 | 王桂琼 | Externally used pharmaceutical for bone fracture |
| CN100333742C (en) * | 2005-07-29 | 2007-08-29 | 陆光富 | Chinese materia medica preparation for curing fracture and traumatic injury |
| CN101816714A (en) * | 2010-04-29 | 2010-09-01 | 昆明理工大学 | Chinese traditional medicine for promoting fracture healing and preparation method thereof |
| CN103156917A (en) * | 2013-03-16 | 2013-06-19 | 营口三花制药有限公司 | Preparation method of Sanhua bone setting powder |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1026554C (en) * | 1989-09-07 | 1994-11-16 | 苏宝娟 | Production method of a plaster |
| CN1054894A (en) * | 1990-03-16 | 1991-10-02 | 张振庆 | Mus chicken osteosynthesis medicine and preparation method thereof |
| CN1053190A (en) * | 1991-01-17 | 1991-07-24 | 孙利胜 | The method for production of Chinese medicine preparation " bone knitting powder " |
-
1992
- 1992-12-18 CN CN92114507A patent/CN1035717C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1044685C (en) * | 1993-07-21 | 1999-08-18 | 陈俊如 | Traditional Chinese medicine for treating bone fracture |
| CN1069037C (en) * | 1995-04-05 | 2001-08-01 | 唐兴华 | Method for preparing oral capsule for treating difficult and complicated fracture |
| CN1054295C (en) * | 1995-05-19 | 2000-07-12 | 张治国 | Patent drug- "jiegu" powder medicine for treatment of fracture |
| CN1059096C (en) * | 1996-01-05 | 2000-12-06 | 李振 | Method of preparing medicated wine for treating injury and setting bone |
| KR100330924B1 (en) * | 1996-12-05 | 2002-10-04 | 주식회사 엘지씨아이 | Oral composition containing extract of ulmi cortex for treatment of periodontal diseases |
| CN1060387C (en) * | 1997-07-31 | 2001-01-10 | 包学仁 | Bone-knitting pill and producing process thereof |
| CN1292768C (en) * | 2001-02-22 | 2007-01-03 | 王桂琼 | Externally used pharmaceutical for bone fracture |
| CN100333742C (en) * | 2005-07-29 | 2007-08-29 | 陆光富 | Chinese materia medica preparation for curing fracture and traumatic injury |
| CN101816714A (en) * | 2010-04-29 | 2010-09-01 | 昆明理工大学 | Chinese traditional medicine for promoting fracture healing and preparation method thereof |
| CN103156917A (en) * | 2013-03-16 | 2013-06-19 | 营口三花制药有限公司 | Preparation method of Sanhua bone setting powder |
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| Publication number | Publication date |
|---|---|
| CN1035717C (en) | 1997-08-27 |
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