CN1069037C - Method for preparing oral capsule for treating difficult and complicated fracture - Google Patents
Method for preparing oral capsule for treating difficult and complicated fracture Download PDFInfo
- Publication number
- CN1069037C CN1069037C CN95111304A CN95111304A CN1069037C CN 1069037 C CN1069037 C CN 1069037C CN 95111304 A CN95111304 A CN 95111304A CN 95111304 A CN95111304 A CN 95111304A CN 1069037 C CN1069037 C CN 1069037C
- Authority
- CN
- China
- Prior art keywords
- radix
- fracture
- capsule
- root
- difficult
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010010149 Complicated fracture Diseases 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 title claims abstract description 8
- 229940100691 oral capsule Drugs 0.000 title claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 8
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 8
- 239000002775 capsule Substances 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 6
- 238000001704 evaporation Methods 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 241000628997 Flos Species 0.000 claims description 7
- 239000009636 Huang Qi Substances 0.000 claims description 7
- 241001464849 Ophisaurus Species 0.000 claims description 6
- 238000012856 packing Methods 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 238000005325 percolation Methods 0.000 claims description 5
- 239000009286 sanguis draxonis Substances 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000019634 flavors Nutrition 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 3
- 238000009792 diffusion process Methods 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000012466 permeate Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000004064 recycling Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 238000009834 vaporization Methods 0.000 claims description 2
- 230000008016 vaporization Effects 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 208000010392 Bone Fractures Diseases 0.000 abstract description 11
- 206010017076 Fracture Diseases 0.000 abstract description 10
- 206010027476 Metastases Diseases 0.000 abstract description 2
- 206010028980 Neoplasm Diseases 0.000 abstract description 2
- 210000000988 bone and bone Anatomy 0.000 abstract description 2
- 201000011510 cancer Diseases 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 210000002436 femur neck Anatomy 0.000 abstract description 2
- 230000009401 metastasis Effects 0.000 abstract description 2
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 241001233914 Chelidonium majus Species 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 241001116742 Drynaria Species 0.000 abstract 1
- 206010034156 Pathological fracture Diseases 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 208000005250 Spontaneous Fractures Diseases 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940068560 greater celandine Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000011443 conventional therapy Methods 0.000 description 1
- 230000002478 diastatic effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a method for preparing oral capsule for treating difficult and complicated fracture, which is prepared from Chinese medicinal materials of prepared rhizome of rehmannia, dipsacus root, drynaria rhizome, root of red rooted saliva, safflower, notoginseng, Chinese angelica root, astragalus root and greater celandine through the steps of disintegrating, ethanol immersing, percolating, decompressing evaporating, drying, granulating, loading into capsules and packaging, wherein the capsule has definite curative effect on the pathological fracture of cancer bone metastasis, old separated fracture and nonunion after fracture of femoral neck of old age, which is not solved clinically in orthopaedics in our country, and has obvious curative rate up to 98%, cure rate up to 100% for fresh fracture, no functional disorder left, shortened half of treatment time and fills the gap in difficult and complicated fracture treatment in our country.
Description
The present invention relates to a kind of manufacture method for the treatment of the difficult and complicated fracture oral drugs.
The traditional therapy of fracture is outer Plastering, and last small splints fixation allows bone fracture place normal healing, generally needs 2-3 individual month.Because union of fracture is slow, the relative fixed time is long, causes dysfunction, brings life to the patient, the inconvenience of work.And some difficult and complicated fractures can not be cured for a long time, cause the patient maimed throughout one's life.
In view of the limitation of tradition fracture therapy, the objective of the invention is to excavate motherland's medical science precious deposits, outstanding Chinese medicine characteristic, develop and a kind ofly can remove the fracture patient misery, also can save numerous patients from maimed person's edge the new drug of the treatment difficult and complicated fracture of returning.
The manufacture method of treatment difficult and complicated fracture oral capsule provided by the invention is to select for use genuine Chinese crude drug Radix Rehmanniae Preparata, Radix Dipsaci, Rhizoma Drynariae, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Notoginseng, Radix Angelicae Sinensis, the Radix Astragali, Herba Chelidonii, Ophisaurus manufacturing to form, by 100%, the shared percentage by weight of each Chinese medicine of distinguishing the flavor of is with patent medicine weight:
Radix Rehmanniae Preparata 7～14% Rhizoma Drynariae 8～18%
Herba Chelidonii 8～16% Ophisaurus 8～15%
Radix Notoginseng 7～13% Sanguis Draxonis 10～14%
Radix Angelicae Sinensis 7～10% Radix Salviae Miltiorrhizaes 10～13%
Radix Dipsaci 4～7% Flos Carthamis 5～9%
The Radix Astragali 8～11%
The production technology of this medicine is as follows:
One, levigation percolation:
Each flavor Chinese medicine is come out by the prescription weighing, be developed into coarse powder altogether, in the percolator of packing into, add the soak with ethanol 12 hours of 75% concentration, make solvent fully permeate diffusion,, be generally decompression recycling ethanol 2～3 times with the speed percolation of per minute 3～5ml.
Two, reduction vaporization:
To remove alcoholic acid medicinal liquid and place in the evaporation boiler, attemperation is made into the thick paste shape between 40～60 ℃.
Three, drying and granulating:
Thick paste is positioned in the drying baker oven dry, makes granule then.
Four, encapsulated:
With capsule racking machine on the drug particles, dress up capsule by standard, packing, the oral capsule produced of the inventive method.
Treatment difficult and complicated fracture oral capsule according to prescription provided by the invention and production technology manufacturing, to cancer bone metastasis pathologisch Bruch, old diastatic fracture, the still unsolved clinically difficult problem determined curative effect of China's orthopaedics at present such as disunion after the old fracture of femoral neck, and highly significant, most thousand routine case clinical verifications through 7 years, cure rate reaches 98%, the treatment of fresh fracture is shortened half than the conventional therapy time, cure rate reaches 100%, generally do not leave over dysfunction, have and treat fast, cure rate advantages of higher.Succeeding in developing of this medicine is the important breakthrough of treatment difficult and complicated fracture, filled up the China and the blank of clinical treatment difficult and complicated fracture in the world, is the orthopaedics new drug that a kind of utmost point has promotional value.
Provide embodiment below:
Example 1:
With Radix Rehmanniae Preparata 13g Rhizoma Drynariae 9g Herba Chelidonii 15g Flos Carthami 5g
Ophisaurus 15g Radix Notoginseng 7g Sanguis Draxonis 10g Radix Astragali 8g
Radix Angelicae Sinensis 9g Radix Salviae Miltiorrhizae 12g Radix Dipsaci 4g is ground into coarse powder altogether, in the percolator of packing into, adds 75% soak with ethanol 12 hours, makes solvent fully permeate diffusion, with the speed percolation of per minute 3～5ml 2～3 times, and decompression recycling ethanol.
Remove alcoholic acid medicinal liquid and insert in the evaporation boiler above-mentioned, temperature is controlled at 40～60 ℃, makes the thick paste shape.
Thick paste is positioned over oven dry (temperature is controlled at 40～60 ℃) in the drying baker, makes granule then.
With capsule racking machine on the drug particles, dress up capsule by standard, packing promptly gets and specially controls difficult and complicated fracture, oral capsule evident in efficacy.
Example 2:
With Radix Rehmanniae Preparata 10g Rhizoma Drynariae 12g Herba Chelidonii 12g
Ophisaurus 11g Radix Notoginseng 10g Sanguis Draxonis 10g
Radix Angelicae Sinensis 8g Radix Salviae Miltiorrhizae 10g Radix Dipsaci 5g
Flos Carthami 8g Radix Astragali 9g.Production technology such as example 1.
Example 3:
With Radix Rehmanniae Preparata 14g Rhizoma Drynariae 15g Herba Chelidonii 15g
Ophisaurus 15g Radix Notoginseng 12g Sanguis Draxonis 12g
Radix Angelicae Sinensis 10g Radix Salviae Miltiorrhizae 11g Radix Dipsaci 7g
Flos Carthami 9g Radix Astragali 11g.All the other operations are with example 1.
Claims (1)
1, the manufacture method of treatment difficult and complicated fracture oral capsule, it is characterized in that selecting for use genuine Chinese crude drug Radix Rehmanniae Preparata, Radix Dipsaci, Rhizoma Drynariae, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Notoginseng, Radix Angelicae Sinensis, the Radix Astragali, Herba Chelidonii, process through science, by 100%, the shared percentage by weight of each Chinese medicine of distinguishing the flavor of is with patent medicine weight:
Radix Rehmanniae Preparata 7～14% Rhizoma Drynariae 8～18%
Herba Chelidonii 8～16% Ophisaurus 8～15%
Radix Notoginseng 7～13% Sanguis Draxonis 10～14%
Radix Angelicae Sinensis 7～10% Radix Salviae Miltiorrhizaes 10～13%
Radix Dipsaci 4～7% Flos Carthamis 5～9%
The Radix Astragali 8～11%
Production technology is as follows:
One, levigation percolation:
Each flavor Chinese medicine is come out by the prescription weighing, be ground into coarse powder altogether, in the percolator of packing into, add the soak with ethanol 12 hours of 75% concentration, make solvent fully permeate diffusion,, be generally decompression recycling ethanol 2～3 times with the speed percolation of per minute 3～5ml;
Two, reduction vaporization:
To remove alcoholic acid medicinal liquid and place in the evaporation boiler, attemperation is made into the thick paste shape between 40～60 ℃;
Three, drying and granulating:
Thick paste is positioned in the drying baker dries, make granule then;
Four, encapsulated:
With capsule racking machine on the drug particles, dress up capsule by standard, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95111304A CN1069037C (en) | 1995-04-05 | 1995-04-05 | Method for preparing oral capsule for treating difficult and complicated fracture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95111304A CN1069037C (en) | 1995-04-05 | 1995-04-05 | Method for preparing oral capsule for treating difficult and complicated fracture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1127131A CN1127131A (en) | 1996-07-24 |
| CN1069037C true CN1069037C (en) | 2001-08-01 |
Family
ID=5078607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95111304A Expired - Fee Related CN1069037C (en) | 1995-04-05 | 1995-04-05 | Method for preparing oral capsule for treating difficult and complicated fracture |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1069037C (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071843A (en) * | 1992-12-18 | 1993-05-12 | 柳海峰 | The preparation method of " three-flower " bone-knitting powder |
| CN1084765A (en) * | 1993-07-21 | 1994-04-06 | 陈俊如 | Stasis-removing bone-setting medicine |
| CN1090196A (en) * | 1993-10-30 | 1994-08-03 | 陈显志 | Liquid for curing bone fracture |
| CN1098935A (en) * | 1994-05-23 | 1995-02-22 | 柴开源 | A kind of relaxing muscles and tendons to promote blood circulation Chinese medicine composition and preparation method thereof |
-
1995
- 1995-04-05 CN CN95111304A patent/CN1069037C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071843A (en) * | 1992-12-18 | 1993-05-12 | 柳海峰 | The preparation method of " three-flower " bone-knitting powder |
| CN1084765A (en) * | 1993-07-21 | 1994-04-06 | 陈俊如 | Stasis-removing bone-setting medicine |
| CN1090196A (en) * | 1993-10-30 | 1994-08-03 | 陈显志 | Liquid for curing bone fracture |
| CN1098935A (en) * | 1994-05-23 | 1995-02-22 | 柴开源 | A kind of relaxing muscles and tendons to promote blood circulation Chinese medicine composition and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1127131A (en) | 1996-07-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1057451C (en) | Children coryza medicine and preparing method | |
| CN102145128A (en) | Medicinal composition for preventing and treating cardiac and cerebral vascular diseases and preparation method thereof | |
| CN1027622C (en) | A tonic and health protecting preparation | |
| CN1118258A (en) | Preparation of brain-care pill | |
| CN1965951A (en) | Blood tonic capsule having ass hide and method for preparing same | |
| CN100512855C (en) | Method for preparing medication of gastrodia tuber and tuber of multiflower knotweed | |
| CN1069037C (en) | Method for preparing oral capsule for treating difficult and complicated fracture | |
| CN1404854A (en) | Medicine for treating nosal inflammation | |
| CN1712060A (en) | Preparation of Chinese medicinal mixture for treating gynecologic menstrual disease | |
| CN1025774C (en) | Special "shanhaidan" and its production method | |
| CN103285128B (en) | Traditional Chinese medicine for treating bronchial asthma and preparation method thereof | |
| CN1261130C (en) | Medicine for dispelling tinea | |
| CN1194733C (en) | Medicine for treating hyperthyroidism and its prepn | |
| CN1060663C (en) | Compound Tibet capillary artemisia patent medicine | |
| CN1036503C (en) | Medicine for treating systemic lupus erythematosus and producing method thereof | |
| CN1164318C (en) | Capsule for treating gynaecological inflammation | |
| CN1163252C (en) | Tianjian capsule and its preparing process | |
| CN101693065A (en) | Medicament for treating polymyalgia rheumatica and preparation method thereof | |
| CN1238028C (en) | Method for preparing capsule of six drugs containing rehmannine | |
| CN101194940A (en) | Anti-inflammation medicament for treating toothache and preparation method thereof | |
| CN1943717A (en) | A Chinese traditional medicinal composition for treatment of low blood pressure and its preparation method | |
| CN1068217C (en) | Traditional Chinese medicine for treating skin disease and veneral disease | |
| CN1064844C (en) | Chinese medicine | |
| CN1175461A (en) | Medicine composition for treating cardiovascular and cerebrovascular diseases and preparing process thereof | |
| CN1119116A (en) | Medicine for curing angiocardiopathy and cerebrovascular diseases and preparing process thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |