CN1927371A - Blood flow promoting pellet and preparing process thereof - Google Patents

Abstract

Disclosed is a medicament for the treatment of traumatic injury and bone fracture, as well as the preparing process, wherein the medicament is prepared from raw materials including large-leaf gentian root, bark of eucommia, safflower, eucommia bark, Cinnamomum cassia, notoginseng, licorice root and peach kernel by the weight ratio of 0.5-1.5:0.5-1.5:0.5-1.5:0.5-1.5:0.5-1.5: 0.5-1.5:0.5-1.5:0.5-1.5.

Description

HUOXUEDAN and preparation method thereof

Technical field

The present invention relates to a kind of pharmaceutical composition for the treatment of traumatic injury, fracture, red and swollen heat pain, particularly relating to a kind of is the medicine and preparation method thereof of the treatment traumatic injury made of raw material and fracture tendon breaking with the vegetable Chinese herbal medicine.

Background technology

The general methods such as artificial synthetism, operation synthetism that adopt of the Therapeutic Method of existing bone injury disease.Employing is by X-ray machine or other means, after fractures is resetted, utilizes clamping plate, plaster bandage or operation steel plate to fix, clothes antibiotic medicine or treatment drug for traumatic injuries, rest about three months, but after implementing positive reduction, owing to utilize the osmosis of herb medicinal paste for external application, make its curative effect slow, and the many-sided reason of patient's oneself factor, easily make fracture site appearance overlapping displacement in various degree, cause the position swelling pain, cause to stretch and bend miopragia or forfeiture, bring very big misery to the patient.If adopting the operation steel plate fixes, after union of fracture, also need carry out second operation, take out steel plate and fixing steel nail, just well imagined to the misery that the patient causes, and staying the people on skeleton again is the screw hole that causes, and causes the bone of fracture to repair once more, and this has the myelitic possibility of infection again simultaneously.Though the medicine of treatment fracture at present is a lot, softening the hard mass and analgesic effect are bad, and the synthetism healing time is long, and patient is painful big.

Summary of the invention

A kind of HUOXUEDAN for the treatment of traumatic injury, fracture tendon breaking, red and swollen heat pain that provides at the problems referred to above and preparation method thereof is provided, the present invention has healing stage weak point, instant effect, has no side effect and untoward reaction, therapeutic effect is remarkable, characteristics such as cost is low, to traumatic injury, the fracture tendon breaking, red and swollen heat pain, better curative effect is arranged.And can promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, relaxing muscles and tendons and activating QI and blood in the collateral.

In order to realize purpose of the present invention, the technical solution used in the present invention is:

HUOXUEDAN, it is the medicament of being made by the following weight proportion raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5.

Wherein the weight proportion of each raw material is: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2.

Wherein the weight proportion of each raw material is: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=1: 1: 1: 1: 1: 1: 1: 1: 1.

The preparation method of HUOXUEDAN, it is the medicament of being made by the following weight proportion raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5;

Its preparation method may further comprise the steps:

1, above-mentioned each single medicinal material is selected, clean, dry back pulverizes with pulverizer, crosses 120 mesh sieves;

2, get the abundant mixing of each single medicinal material after the pulverizing according to the above ratio, be distributed into bag.

Advantage and effect that the present invention had are:

1, the present invention is a pure Chinese medicinal preparation, has no side effect and untoward reaction, and any artificial fixed form such as do not need train wheel bridge, planter cast, tie up has alleviated patient's misery, has also alleviated patient's financial burden simultaneously.

2, short, the instant effect of healing stage of the present invention.Take this medicine and got final product obvious pain relieving in 20 minutes, the clinical practice proof is compared with traditional therapy can shorten the course of treatment 1/2nd.

3, the present invention is on the basis of secret recipe handed down in the family, and surplus the clinical practice 40 year, the consistent curative effect that reflects of patient is very good again, and drug effect is rapid, total effective rate 99, obvious effective rate 96%.

4, the present invention has better curative effect to traumatic injury, fracture tendon breaking, red and swollen heat pain.And can promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, relaxing muscles and tendons and activating QI and blood in the collateral.

Be to show the curative effect of the present invention to the treatment fracture, the present invention is through the clinical observation of 100 routine systems, selects medical history, the state of an illness, age, 100 routine matched groups that sex is suitable again, is hospitalization, all do not use any showy reiolaena root-bark before the treatment.The bone injury patient is divided at random takes the present invention's " HUOXUEDAN " group (hereinafter to be referred as the treatment group) and " SHEXIANG JIEGU JIAONANG " group (hereinafter to be referred as matched group), 100 examples are organized in treatment, age minimum 8 years old, the oldest 60 years old, 50 years old mean age, M-F 4: 1; Matched group 100 examples, at minimum 8 years old of age, the oldest 60 years old, 55 years old mean age, M-F 4: 1 was hospitalization, did not all use any bone-setting medicament before the treatment.Medication: oral HUOXUEDAN, with yellow wine or warm water delivery service, adult every day three times, each 2-3 gram, the child reduces by half.Avoid clothes rareripe, Rhizoma Zingiberis Recens, living Bulbus Allii, big Radix Raphani during the medication, be not taken by pregnant women, the careful usefulness of patients with gastric disease.Be grown up 5 of every clothes of SHEXIANG JIEGU JIAONANG, 2 of the every clothes of child, every day 3 times.Continuous use 20-40 days, observe therapeutic outcome at any time, affected part swelling regression time was taken the photograph sheet once in per 7 days, checked para-position and growth of spur situation and trouble limb functional rehabilitation time.Curative effect judging standard (1) produce effects: the similar healing time of clinical application time ratio shifts to an earlier date 1/3～1/4, reaches clinical healing standard person.(2) effective: administration time shifts to an earlier date 1/4～1/5 than similar healing time clinically, reaches clinical healing standard person.(3) invalid: administration time is identical with the normal healing time of similar fracture clinically., details see the following form:

The clinical all symptom curative effects of table one treatment group and matched group relatively

Symptom	The treatment group				Matched group
									The example number	Produce effects	Effectively	Invalid	The example number	Produce effects	Effectively	Invalid
	Following comminuted fracture soft tissue injury fracture of neck of radius vertebral fracture upper arm ankle cervical region comminuted fracture of ancon humerus	18 18 17 17 20	16 18 15 17 20	18 18 16 17 20	1	15 16 20 19 21		10 7 13 10 15									5 9 7 9 6

Fracture of shaft of femur case load effective percentage % inefficiency %

10 100

10 96 (96)

10 99 (99)

1 (1)

9 100

5 60 (60)

4 40 (40)

Table two treatment group and matched group curative effect are relatively

Group	The example number	Produce effects		Effectively		Invalid		Obvious effective rate %	Total effective rate %	Inefficiency %
											Example	％	Example	％	Example	％
		Treatment group matched group	100 100	96 0	(96) 0	99 60	(99) (60)										1 40	(1) (40)	96 0	99 60	1 40

Conclusion:

Clinical observation result proves, oral HUOXUEDAN of the present invention has good therapeutical effect to the treatment fracture, have no side effect, HUOXUEDAN of the present invention to traumatic injury, the fracture tendon breaking, red and swollen heat pain, have better curative effect, and promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, relaxing muscles and tendons and activating QI and blood in the collateral, be a kind of pure Chinese medicinal preparation of determined curative effect.

Be some concrete cases below:

Patient's name: Wang Zhenhong.Sex: man.Age: 8 years old.On calendar year 2001, November 2 was by bed, fall, cause right following comminuted fracture of ancon humerus, under the invalid situation of other hospitalize in late November your orthopedics department out-patient treatment.The right capped elbow of patient expands during outpatient service at that time, and clamping plate are fixed, and show right upper arm ankle cervical region comminuted fracture from strap.Elbow joint dysfunction.Limitation of activity.HUOXUEDAN for oral administration is taken medicine by adult's half amount, and combined function is taken exercise simultaneously.Substantially reached union of fracture in one month, functional activity is near normal.

Patient's name: sweet organ.Sex: woman.Age: 60 years old.The right carpal joint of in February, 2005 traumatic injury.Went at that time other hospital to be diagnosed as right fracture of neck of radius.Manual reduction, clamping plate are fixed, amber bolus for oral administration, treating made film after 3 months finds that the fracture para-position is not good enough, right carpal joint can not turn up.The right hand can not be held.Finger is stretched not straight, swelling pain.In June, 2005 is your orthopedics department clinic treatment, HUOXUEDAN for oral administration, and cooperate manual massage, and the treatment two weeks right hand can be combed one's hair, washes one's face, be had a meal, and it is normal that movable function recovers substantially.

The specific embodiment

Embodiment 1:

HUOXUEDAN is taken off by following weight proportion and to be stated raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae=0.5: 1.5: 1.5: 1.5: 1.5: 1.5: 1.5: 1.5.

Its preparation method may further comprise the steps:

1, above-mentioned each single medicinal material is selected, clean, dry back sieve removes dust and impurity, the reuse pulverizer is pulverized, and crosses 120 mesh sieves;

2, get according to the above ratio each single medicinal material after the pulverizing carry out behind the abundant mixing the former powder of Chinese medicine, the former powder of Chinese medicine is distributed into every bag 2.5 gram.

Embodiment 2:

HUOXUEDAN is taken off by following weight proportion and to be stated raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae=1.5: 0.5: 0.5: 0.5: 0.5: 0.5: 0.5: 0.5.

Its preparation method is with embodiment 1.

Embodiment 3:

HUOXUEDAN is taken off by following weight proportion and to be stated raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae=0.8: 1.2: 1.2: 1.2: 1.2: 1.2: 1.2: 1.2.

Its preparation method is with embodiment 1.

Embodiment 4:

HUOXUEDAN is taken off by following weight proportion and to be stated raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae=1.2: 0.8: 0.8: 0.8: 0.8: 0.8: 0.8: 0.8.

Its preparation method is with embodiment 1.

Embodiment 5:

HUOXUEDAN is taken off by following weight proportion and to be stated raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae=1: 1: 1: 1: 1: 1: 1: 1.

Its preparation method is with embodiment 1.

Claims (4)

1, HUOXUEDAN is characterized in that it is the medicament of being made by the following weight proportion raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5.

2, HUOXUEDAN according to claim 1 is characterized in that wherein the weight proportion of each raw material is: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2.

3, HUOXUEDAN according to claim 1 is characterized in that wherein the weight proportion of each raw material is: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=1: 1: 1: 1: 1: 1: 1: 1: 1.

4, the preparation method of HUOXUEDAN is characterized in that it is the medicament of being made by the following weight proportion raw material: Radix Gentianae Macrophyllae: Radix Dipsaci: Flos Carthami: the Cortex Eucommiae: Cortex Cinnamomi: Radix Notoginseng: Radix Glycyrrhizae: Semen Persicae: Rhizoma Curcumae Longae=0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5: 0.5-1.5;

Its preparation method may further comprise the steps:

1, above-mentioned each single medicinal material is pulverized with pulverizer, crossed 120 mesh sieves;

2, get the abundant mixing of each single medicinal material after the pulverizing according to the above ratio, be distributed into bag.