CN100411661C - Amber bolus - Google Patents
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- CN100411661C CN100411661C CNB2005100462228A CN200510046222A CN100411661C CN 100411661 C CN100411661 C CN 100411661C CN B2005100462228 A CNB2005100462228 A CN B2005100462228A CN 200510046222 A CN200510046222 A CN 200510046222A CN 100411661 C CN100411661 C CN 100411661C
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Abstract
The present invention relates to a bone-setting medicine and a preparing method thereof for treating bone fractures, more specifically a Chinese patent medicine prepared from Chinese medicinal herbs as raw materials. The bone-setting medicine which can treat fractures and soft tissue injuries is prepared by that native copper (calcined), sanqi, fortune's drynaria rhizome (prepared), himalayan teasel root, Chinese taxillus twig, ground beeltle, dragon's blood, safflower, frankincense (prepared), myrrh (prepared), angelica, earthworm, hairy deerhorn, deglued antler, amber, dahurian angelica, hite mulberry root-bark, red peony root and yanhusuo are screened, dried and pulverized to be sieved by a sieve with 120 meshes; after being qualified through drugh testing, the powdered medicine is mixed with honey with the water content of 5 to 10% and the density of 1.38 to 1.40 g/ml according to the ration of 1:1; the powdered medicine and the honey are uniformly stirred to prepare pills. The compounding provided by the present invention has definite curative effects and is an ideal medicine which can quickly treat fractures and soft tissue injuries. The preparing method of the present invention has the advantages of simplicity and easy processing.
Description
Technical field
The present invention relates to a kind of bone-setting medicament for the treatment of fracture, is the Chinese patent medicine of preparation of raw material with the Chinese herbal medicine specifically, can treat fracture and soft tissue injury, the invention still further relates to the preparation method of this medicine.
Background technology
For the treatment of fracture and soft tissue injury, doctor trained in Western medicine mainly is to adopt the antibiotic anti-inflammatory analgetic, and takes vitamins and calcium preparation; The traditional Chinese medical science mainly is to adopt promoting blood circulation and stopping pain, eliminating blood stasis to promote regeneration of blood, reunion of fractured tendons and bones class Chinese medicine preparation.Chinese medicine once used Chinese medicine preparation such as pill for traumatic injuries, powder for traumatic injuries, JIUFEN POWDER, Anisodus carniolicoides C.Y.Wu et C.Chen clinically, because said medicine exists gastrointestinal tract is had the stimulation side effect, and medicine stability was poor, and curative effect is not good enough, and country has notified and stopped using.Mainly use Flos Carthami injection, SHENYANG HONGYAO, Cortex torricelliae tiliifoliae etc. at present clinically, the main pharmacological of Flos Carthami injection and SHENYANG HONGYAO is promoting blood circulation and stopping pain, eliminating blood stasis to promote regeneration of blood, and the effect of reunion of fractured tendons and bones is little; Though Cortex torricelliae tiliifoliae is having certain effect aspect reducing swelling and alleviating pain, the reunion of fractured tendons and bones, exist shortcomings such as treatment cycle is long, uncertain therapeutic efficacy is cut.Western medicine mainly use to promote clinically the calcium preparation of knitting such as bone peptide injection, soft spirit etc., but exist shortcomings such as treatment cycle is long, uncertain therapeutic efficacy is cut, and cost an arm and a leg, general patient is difficult to bear.The deficiency that above medicine exists is the problem that relevant medical department is comparatively paid close attention to always.
Summary of the invention
The objective of the invention is deficiency, provide a kind of for treatment fracture and soft tissue injury determined curative effect, the more satisfactory medicine amber bolus that treatment cycle is short at the said medicine existence.
Another object of the present invention provides the preparation method of this amber bolus.
The present invention makes (consumption is a weight portion) by the raw material of following Chinese herbal medicine:
5～25 parts of Pyritum (calcined)s, 5～25 parts of Radix Notoginseng, 4～15 parts of Rhizoma Drynariae (processed)s, 4～15 parts of Radix Dipsacis, 4～15 parts of Herba Taxillis, 8～25 parts of Eupolyphaga Seu Steleophagas, 5～25 parts of Sanguis Draxonis, 80～150 parts on Flos Carthami, 10～25 parts of Olibanum (processed)s, 10～25 parts of Myrrha (processed)s, 4～15 parts of Radix Angelicae Sinensis, 8～25 parts of Pheretimas, 4～15 parts in Cornu Cervi Pantotrichum, 100～240 parts of Cornu Cervi Degelatinatums, 10～50 parts of succinums, 8～25 parts of the Radixs Angelicae Dahuricae, 8～25 parts of Cortex Mori, 6～15 parts of Radix Paeoniae Rubra, 6～15 parts of Rhizoma Corydalis.
The present invention is to be monarch drug with the Pyritum (calcined), eliminating stasis to stop pain, reunion of bone.The Pyritum (calcined) promoting the circulation of bloodization stagnates, and the merit of eliminating stasis to stop pain is arranged, and can synthetism hinder to treat folding, is the traumatology medication.Radix Notoginseng, Eupolyphaga Seu Steleophaga, Rhizoma Drynariae (processed), Radix Dipsaci, Herba Taxilli, Sanguis Draxonis, Flos Carthami, Olibanum (processed), Myrrha (processed) activating blood circulation and dissipating blood stasis, reunion of fractured tendons and bones, the energy liver and kidney tonifying of holding concurrently to help the Pyritum (calcined) efficacy of a drug, is ministerial drug.Radix Notoginseng hemostasis and do not stay the stasis of blood is used for traumatic injury, the stasis of blood stagnates and swells and ache, and the merit of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain is arranged, and is longer than pain relieving especially.But the Sanguis Draxonis external, also oral administration takes the promoting blood circulation to remove blood stasis pain relieving orally.The Flos Carthami blood circulation promoting and blood stasis dispelling, stimulate the menstrual flow.The merit of this product blood circulation promoting and blood stasis dispelling is excellent, and to traumatic injury, stasis of blood pain, arthralgia, compatibilities such as system and Olibanum, Myrrha (processed) strengthen the promoting blood circulation to remove blood stasis effect, altogether the power of principal drug assistance.It is capable stagnant to increase the Radix Paeoniae Rubra blood stasis dispelling, alleviating pain.Eupolyphaga Seu Steleophaga, Rhizoma Drynariae (processed), Radix Dipsaci, Herba Taxilli, but invigorating the liver and kidney reuniting the fractured tendons and bones.The traditional Chinese medical science is thought " The liver and the kidney have a common source " liver and kidney tonifying, can beneficial menses, the Shujin bone.The above-mentioned invigorating the liver and kidney of Fang Zhongyong, reunion of fractured tendons and bones can be total to the merit of principal drug assistance.Radix Angelicae Sinensis, Pheretima promoting blood circulation to restore menstrual flow add the Rhizoma Corydalis promoting the circulation of QI to relieve pain, to help pseudo-ginseng blood-circulation-invigovating, to nourish blood.Cornu Cervi Pantotrichum, Cornu Cervi Degelatinatum aid yang qi are restrained granulation promoting, and can be stopped blooding with hemopoietic.The succinum tranquillizing the mind by relieving convulsion is an adjuvant drug.The Cornu Cervi Degelatinatum kidney tonifying is supporing yang, contains abundant calcareously, and the merit of the existing liver and kidney tonifying of a large amount of Cornu Cervi Degelatinatums of Fang Zhongyong can be replenished the calcium again.Bone decreases the injury of tendon and muscle, swelling and pain due to blood stasis.Patient's initial stage pain is lain awake all night unbearably, and succinum can play the effect of tranquillizing the mind by relieving convulsion.The Radix Angelicae Dahuricae, Cortex Mori dampness, dampness removing, it is a messenger drug, all medicines share, but reunion of fractured tendons and bones, blood circulation promoting and blood stasis dispelling.The dehumidifying of nourishing blood all promotes callus formation, helps the power of reunion of fractured tendons and bones.
The proportion optimization weight (part) of medicine of the present invention is: 10～20 parts of Pyritum (calcined)s, 10～20 parts of Radix Notoginseng, 6～10 parts of Rhizoma Drynariae (processed)s, 6～10 parts of Radix Dipsacis, 6～10 parts of Herba Taxillis, 10～23 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Sanguis Draxonis, 100～130 parts on Flos Carthami, 15～22 parts of Olibanum (processed)s, 15～22 parts of Myrrha (processed)s, 6～10 parts of Radix Angelicae Sinensis, 12～23 parts of Pheretimas, 6～10 parts in Cornu Cervi Pantotrichum, 150～200 parts of Cornu Cervi Degelatinatums, 20～40 parts of succinums, 12～23 parts of the Radixs Angelicae Dahuricae, 12～23 parts of Cortex Mori, 6～12 parts of Radix Paeoniae Rubra, 6～12 parts of Rhizoma Corydalis.
Preferable weight (part) proportioning of medicine of the present invention is: 20 parts of Pyritum (calcined)s, 20 parts of Radix Notoginseng, 10 parts of Rhizoma Drynariae (processed)s, 10 parts of Radix Dipsacis, 10 parts of Herba Taxillis, 23 parts of Eupolyphaga Seu Steleophagas, 20 parts of Sanguis Draxonis, 130 parts on Flos Carthami, 22 parts of Olibanum (processed)s, 22 parts of Myrrha (processed)s, 10 parts of Radix Angelicae Sinensis, 23 parts of Pheretimas, 10 parts in Cornu Cervi Pantotrichum, 200 parts of Cornu Cervi Degelatinatums, 40 parts of succinums, 23 parts of the Radixs Angelicae Dahuricae, 23 parts of Cortex Mori, 12 parts of Radix Paeoniae Rubra, 12 parts of Rhizoma Corydalis.
Making preparation method of the present invention is: with raw material screen respectively, dry, pulverized 120 mesh sieves, autoclaving, treat pulverous medicine after medicine inspection is qualified with water content 5～10%, density be the Mel of 1.38～1.40g/ml by 1: 1 mixed, stir, make pill.
The given medicine of the present invention is when treatment fracture and soft tissue injury, not only can play rapid detumescence, pain relieving, reunion of fractured tendons and bones effect, and can shorten the healing time of fracture patient, to treatment open fracture, bone do not connect, delayed union disease and osteonecrosis, soft tissue injury etc. have good effect, its determined curative effect, treatment cycle is short, does not have secondary the use, is the ideal medicament of a kind of quickly treating fracture and soft tissue injury.The preparation method of this medicine is simple, is easy to processing, is convenient to clinical use.
The specific embodiment
Embodiment 1
Take by weighing raw material by following weight proportion:
With 25 parts of Pyritum (calcined)s, 25 parts of Radix Notoginseng, 15 parts of Rhizoma Drynariae (processed)s, 15 parts of Radix Dipsacis, 15 parts of Herba Taxillis, 25 parts of Eupolyphaga Seu Steleophagas, 25 parts of Sanguis Draxonis, 150 parts on Flos Carthami, 25 parts of Olibanum (processed)s, 25 parts of Myrrha (processed)s, 15 parts of Radix Angelicae Sinensis, 25 parts of Pheretimas, 15 parts in Cornu Cervi Pantotrichum, 240 parts of Cornu Cervi Degelatinatums, 50 parts of succinums, 25 parts of the Radixs Angelicae Dahuricae, 25 parts of Cortex Mori, 15 parts of Radix Paeoniae Rubra, 15 parts of Rhizoma Corydalis.
Preparation method is as follows: raw material screens respectively, dry, pulverized 120 mesh sieves, autoclaving, Mel (the water content 5～10% that powdery medicine is got well with refining after medicine inspection is qualified, density is the old honey of 1.38～1.40g/ml) by 1: 1 mixed, stir promptly available pellet processing machine processing pill.
Embodiment 2
Get 5 parts of Pyritum (calcined)s, 5 parts of Radix Notoginseng, 4 parts of Rhizoma Drynariae (processed)s, 4 parts of Radix Dipsacis, 4 parts of Herba Taxillis, 8 parts of Eupolyphaga Seu Steleophagas, 5 parts of Sanguis Draxonis, 80 parts on Flos Carthami, 10 parts of Olibanum (processed)s, 10 parts of Myrrha (processed)s, 4 parts of Radix Angelicae Sinensis, 8 parts of Pheretimas, 4 parts in Cornu Cervi Pantotrichum, 100 parts of Cornu Cervi Degelatinatums, 10 parts of succinums, 8 parts of the Radixs Angelicae Dahuricae, 8 parts of Cortex Mori, 6 parts of Radix Paeoniae Rubra, 6 parts of Rhizoma Corydalis.Preparation method is with embodiment 1.
Embodiment 3
Get 10 parts of Chinese herbal medicine Pyritum (calcined)s, 10 parts of Radix Notoginseng, 8 parts of Rhizoma Drynariae (processed)s, 9 parts of Radix Dipsacis, 8 parts of Herba Taxillis, 10 parts of Eupolyphaga Seu Steleophagas, 12 parts of Sanguis Draxonis, 100 parts on Flos Carthami, 15 parts of Olibanum (processed)s, 15 parts of Myrrha (processed)s, 7 parts of Radix Angelicae Sinensis, 12 parts of Pheretimas, 6 parts in Cornu Cervi Pantotrichum, 150 parts of Cornu Cervi Degelatinatums, 20 parts of succinums, 13 parts of the Radixs Angelicae Dahuricae, 13 parts of Cortex Mori, 10 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Corydalis.Preparation method is with embodiment 1.
The present invention can make powder, tablet, capsule or soft capsule.
Case:
1. Yin, the man, 18 years old, right fracture of medial malleolus, the serious edema of fracture site, skin is dark violet, pain unbearably, patient's emotion lather.The row manual reduction, plaster splint external fixation treatment, oral amber bolus is simultaneously taken amber bolus that the present invention provides after one week, and symptom is obviously improved, and patient is irritated, and emotion fades away, and pain obviously alleviates, and the fracture site skin color progressively recovers normally, the edema disappearance.After taking medicine one month, the inspection of X-ray sheet shows that fracture line is fuzzy, and patient's local pain of fracturing disappears substantially, continues oral amber bolus after two weeks, and X-ray film shows that fracture line disappears, and having a medical check-up meets the clinical union of bone sign.
2. Lee, man, 58 years old, the right hand the 4.5th metacarpal fracture, palm redness during patient admission, heating, with dull pain, feeling of numbness.The row manual reduction, the clamping plate external fixation cooperates and takes the amber bolus that the present invention provides, and after the week of taking medicine, symptom is obviously improved.Red and swollen, heating alleviates, and dull pain, feeling of numbness disappear, and patient is emotionally stable, and through X-ray examination, the fracture good apposition has a small amount of callus.Continue oral amber bolus after three weeks, clinical symptoms and sign are recovered normally substantially, and X-ray film shows that fracture line disappears, and a large amount of growth of spur are arranged, and fracture reaches clinical healing.
3. Ma, man, 60 years old, left Patella fracture operative treatment.Normal anti-inflammatory treatment began to take the amber bolus (pressing the given pill of embodiment 1 proportioning raw materials) that the present invention provides after one week, around the postoperative, clapped the check of X-ray sheet, and fracture line is fuzzy, and patient's knee joint begins functional exercise, and in seven weeks of postoperative, fracture reaches clinical healing.
Comparative example: the amber bolus that the present invention provides and the contrast of Western medicine
1. with of the influence of drug for invigorating blood circulation and eliminating stasis Flos Carthami injection drugs compared to external thrombus formation
| Group | The clinical experiment number | Thrombus formation time (second) | Thrombosis length (cm) | Wet weight of thrombus (mg) | Thrombosis dry weight (mg) |
| Model group | 30 | 179.2±46.1 | 5.7±0.6 | 152.6±18.7 | 41.9±5.6 |
| Flos Carthami injection | 30 | 418.8±75.5 | 3.9±0.7 | 79.0±18.1 | 21.9±5.9 |
| Amber bolus | 30 | 573.6±37.2 | 2.5±0.4 | 51.6±17.4 | 15.4±4.3 |
As can be seen from the table, Flos Carthami injection and amber bolus all have the thrombotic effect of inhibition, but amber bolus anti-thrombosis function more remarkable effect.
2. with the drugs compared that promotes the knitting bone peptide injection human femur under loading is done the influence of union of fracture
| Group | The clinical experiment number | The callus formation time (my god) | Osteoclast occur the position (my god) | Healing time (my god) |
| Model group | 20 | 15±2 | Few | 45±10 |
| Flos Carthami injection | 20 | 12±3 | Many | 38±9 |
| Amber bolus | 20 | 10±2 | At most | 30±6 |
As can be seen from the table, bone peptide injection and amber bolus all have the effect that promotes knitting, but the action effect of amber bolus is more obvious.
Claims (5)
1. treat the fracture and the Chinese medicine composition of soft tissue injury for one kind, it is characterized in that it is to be made by following raw materials by weight proportions:
5～25 parts of Pyritum (calcined)s, 5～25 parts of Radix Notoginseng, 4～15 parts of Rhizoma Drynariae (processed)s, 4～15 parts of Radix Dipsacis, 4～15 parts of Herba Taxillis, 8～25 parts of Eupolyphaga Seu Steleophagas, 5～25 parts of Sanguis Draxonis, 80～150 parts on Flos Carthami, 10～25 parts of Olibanum (processed)s, 10～25 parts of Myrrha (processed)s, 4～15 parts of Radix Angelicae Sinensis, 8～25 parts of Pheretimas, 4～15 parts in Cornu Cervi Pantotrichum, 100～240 parts of Cornu Cervi Degelatinatums, 10～50 parts of succinums, 8～25 parts of the Radixs Angelicae Dahuricae, 8～25 parts of Cortex Mori, 6～15 parts of Radix Paeoniae Rubra, 6～15 parts of Rhizoma Corydalis.
2. according to the described Chinese medicine composition of claim 1, it is characterized in that the weight proportion of each crude drug is:
10～20 parts of Pyritum (calcined)s, 10～20 parts of Radix Notoginseng, 6～10 parts of Rhizoma Drynariae (processed)s, 6～10 parts of Radix Dipsacis, 6～10 parts of Herba Taxillis, 10～23 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Sanguis Draxonis, 100～130 parts on Flos Carthami, 15～22 parts of Olibanum (processed)s, 15～22 parts of Myrrha (processed)s, 6～10 parts of Radix Angelicae Sinensis, 12～23 parts of Pheretimas, 6～10 parts in Cornu Cervi Pantotrichum, 150～200 parts of Cornu Cervi Degelatinatums, 20～40 parts of succinums, 12～23 parts of the Radixs Angelicae Dahuricae, 12～23 parts of Cortex Mori, 6～12 parts of Radix Paeoniae Rubra, 6～12 parts of Rhizoma Corydalis.
3. according to the described Chinese medicine composition of claim 1, it is characterized in that the weight proportion of each crude drug is:
20 parts of Pyritum (calcined)s, 20 parts of Radix Notoginseng, 10 parts of Rhizoma Drynariae (processed)s, 10 parts of Radix Dipsacis, 10 parts of Herba Taxillis, 23 parts of Eupolyphaga Seu Steleophagas, 20 parts of Sanguis Draxonis, 130 parts on Flos Carthami, 22 parts of Olibanum (processed)s, 22 parts of Myrrha (processed)s, 10 parts of Radix Angelicae Sinensis, 23 parts of Pheretimas, 10 parts in Cornu Cervi Pantotrichum, 200 parts of Cornu Cervi Degelatinatums, 40 parts of succinums, 23 parts of the Radixs Angelicae Dahuricae, 23 parts of Cortex Mori, 12 parts of Radix Paeoniae Rubra, 12 parts of Rhizoma Corydalis.
4. according to the described Chinese medicine composition of claim 1, it is characterized in that making powder, tablet, capsule.
5. preparation method of the Chinese medicine composition of treatment fracture and soft tissue injury according to claim 1, it is characterized in that with crude drug screen respectively, dry, pulverized 120 mesh sieves, autoclaving, treat that pulverous medicine is that the Mel of 1.38～1.40g/ml was by 1: 1 mixed with water content 5～10%, density after medicine inspection is qualified, stir, make pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100462228A CN100411661C (en) | 2005-04-12 | 2005-04-12 | Amber bolus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100462228A CN100411661C (en) | 2005-04-12 | 2005-04-12 | Amber bolus |
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| CN102552612B (en) * | 2012-03-05 | 2014-04-02 | 肖玉臣 | Traditional Chinese medicine for setting fracture |
| CN102895333A (en) * | 2012-10-30 | 2013-01-30 | 冯悦 | Chinese medicinal preparation for treating soft tissue injury |
| CN104258215A (en) * | 2013-06-18 | 2015-01-07 | 张方元 | Preparation method of agent for treating fractures |
| CN114949104A (en) * | 2022-05-24 | 2022-08-30 | 大连大学附属中山医院 | A Chinese medicinal oral preparation for promoting early healing of fracture and traumatic injury repair, and its preparation method |
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Non-Patent Citations (2)
| Title |
|---|
| 药品标准 中药成方制剂第十二册. 中华人民共和国卫生部药典委员会编，168. 1997 |
| 药品标准 中药成方制剂第十二册. 中华人民共和国卫生部药典委员会编，168. 1997 * |
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