CN1040620C - Preparation of koujiesu - Google Patents

Abstract

The present invention relates to an oral cavity cleaning agent which is essentially composed of the following components that an effective agent is composed of domiphen, thymol and metronidazole; sugar-honey, saccharin sodium, menthol, etc. can be used as an adjuvant which is used for correcting or synthesizing abnormal flavours of the effective agent; glycerin can be used as an additional agent for decreasing the irritation of the effective agent; peppermint oil, clove oil, spearmint oil, etc. can be used as an aromatic type smell correcting agent for oral cavities; solvent is composed of alcohol and distilled water. Indicated by experiments and clinical observation, the present invention can effectively kill pathogenic bacteria in the oral cavities and suppress bacterial reproduction, and has the advantages of good effect of ozostomia removal and no toxic side effects.

Description

A kind of cleaning agent for mouth cavity

The present invention relates to a kind of cleaning agent for mouth cavity, it is mainly used in the formation of bacterial plaque in the control oral cavity, reaches the purpose of prevention and treatment oral disease.

Generally acknowledged that at present bacterial plaque is the topmost paathogenic factor of periodontal disease, the antibacterial of bacterial plaque and metabolite thereof the gingivitis that can start, particularly the relation of some anaerobe and periodontitis is more close.Therefore, the control of bacterial plaque is the important step of prevention and treatment periodontal disease.In prior art, suppressing bacterial plaque formation with chemicals is a kind of method easily and effectively.Generally acknowledge that at present hibitane is one of control bacterial plaque, the comparatively ideal medicine of treatment oral disease, therefore, having occurred many in recent years is the oral-cavity cleaning products of main component with the hibitane, as: hibitane toothpaste, hibitane oral cavity gargarism etc., by clinical verification, its curative effect certainly, but also there are some side effect, as influential to the sense of taste, the puckery hardship of prolonged application deutostoma intracavity, hypogeusia, can cause the dyeing of tooth and lingual surface, phenomenon such as accidentally cause that oral mucosa strips off.And other existing oral cavity gargarism is as compound borax liquid, and the curative effect of control such as hydrogen peroxide bacterial plaque is all undesirable.

The objective of the invention is present situation, a kind of cleaning agent for mouth cavity that can effectively kill main pathogenic bacterium in the oral cavity, suppress bacterial plaque formation and nontoxic pair of effect is provided at prior art.

Solution of the present invention is as follows: this cleaning agent for mouth cavity is made up of following ingredients: disinfectant is made up of domiphen bromide, thymol and metronidazole; Be used to correct or the adjuvant of comprehensive disinfection strange smell is selected for use following a kind of at least: molasses element, saccharin sodium, Mentholum, Folium Stevlae Rebaudianae; Be used to reduce the irritating adjuvant of disinfectant and select glycerol for use; Aroma type oral cavity correctives is selected for use following a kind of at least: Oleum menthae, Oleum Caryophylli, Oleum Menthae Rotundifoliae, Oleum Cinnamomi, apple essence, flavoring orange essence, flavoring banana essence; The solvent that is used to dissolve described disinfectant and adjuvant is ethanol and distilled water.The consumption of above-mentioned each composition all adopts conventional amount used.

Domiphen bromide in the above-mentioned disinfectant is a kind of broad-spectrum disinfectant, is commonly called as domiphen, and formal name used at school is a dodecyl dimethyl benzene oxygen ethyl ammonium bromide.Sterilization experiment was once carried out with this product in 1971 in the General Logistics Department of PLA institute for drug control, had proved it at home in the quaternary ammonium salts disinfectant, and bactericidal action is the strongest.Its bactericidal effect be mainly reflected in to suppurative pathogen, intestinal to kill ability stronger, but relatively poor to the sterilization effect of anaerobe, simultaneously, it also has the vegetative ability of stronger inhibition.As one of disinfectant, mainly is will bring into play the advantage that its sterilizes, bacteriostasis is strong to kill intraoral antibacterial, suppress intraoral bacterial reproduction with it.

Thymol in the aforementioned disinfectant is a kind of phenols disinfectant, its formal name used at school is 2-isopropyl-5-methylphenol, it has the strong characteristics of sterilizing ability, on its bactericidal action mechanism, it has cracking and penetrates bacteria cell wall, makes the ability of bacterial body albumen coagulation sedimentation, it can also reduce solution surface tension, increases the permeability of bacterial cell, and the thalline inclusions is overflowed.In addition, through experiment showed, that thymol has specially good effect to antihalitosis.The present invention selects for use it as the purpose of one of disinfectant to be: be to utilize its antihalitosis on the one hand, be to utilize its penetrance and collaborative other disinfectant of permeability to act on bacterial body better on the other hand, further increase the sterilizing ability of disinfectant.

Metronidazole in the aforementioned disinfectant, formal name used at school are 1-(2-ethoxy)-2-methyl-5-nitro imidazoles, and it is stronger that it kills ability to anaerobe.Is in order to remedy domiphen bromide anaerobe to be killed deficiency a little less than the ability with it as one of disinfectant.

Above-mentioned disinfectant has toxicity, pays effect little, little to the epithelium zest, that safety range is big characteristics, and wherein thymol is stained with the slightly certain zest of film to skin, can adopt the way that adds glycerol to reduce this zest.In addition, above-mentioned disinfectant all has some abnormal flavour, as: domiphen bromide flavor little and if have the soap flavor, it is little smelly that metronidazole has, bitter in the mouth and slightly salty, these abnormal flavour can come comprehensive or correct with the adjuvant that adds fragrant and sweet class, as: can add the molasses element, Mentholum etc.In cleaning agent for mouth cavity, add the oral cavity correctives of aroma type, can make it possess salubrious, fragrant good taste.

For determine cleaning agent for mouth cavity to the effect of oral cavity pathogen and the safety that ensures user with healthy, by Shaanxi Province health and epidemic prevention station cleaning agent for mouth cavity has been done bactericidal assay and the test of human mouth rinsing the mouth and toxicity, stability experiment.The result shows: cleaning agent for mouth cavity when concentration is 1.0% and 0.5% (V/V), acts on 3 minutes under 20 ± 1 ℃ of conditions, all can kill 99.99% staphylococcus aureus; Under above-mentioned same temperature conditions, the cleaning agent for mouth cavity that contains 20% Organic substance 0.5% (V/V) working concentration is with 0.5% (V/V) concentration, and human mouth rinsing the mouth 3 minutes can be killed in the oral cavity 94.52% aerobe and 93.44% anaerobe.Press Ministry of Public Health " disinfection technology standard " evaluation criterion, the true border of cleaning agent for mouth cavity is nontoxic.In order further to determine the fungistatic effect of cleaning agent for mouth cavity, having done the bacteriostatic test of cleaning agent for mouth cavity by a provincial oral cavity doctor again, and to the home and abroad like product to the main pathogenic bacterium in oral cavity---Shanghai refined scholar, Tianjin blue sky, West Germany Dentslol, the U.S. is protected and the bacteriostasis of bright toothpaste has been made contrast test.The result shows that cleaning agent for mouth cavity is to the inhibition zone maximum of the main pathogenic bacterium in oral cavity.Confirmed that cleaning agent for mouth cavity has good fungistatic effect to anaerobe.Subsequently, by four provincial stomatological hospitals cleaning agent for mouth cavity has been carried out the above clinical observation on the therapeutic effect of thousand examples again.The result shows, cleaning agent for mouth cavity is 97.4% to oral disease gingivitis, periodontitis, recurrent aphtha treatment effective percentage, is 97.4% to the effective percentage of oral cavity common sympton gingival hemorrhage, halitosis etc.Observe from clinical long-term effect, uninterrupted continuously with the patient in 2 years of cleaning agent for mouth cavity, there is not any untoward reaction.Thereby confirmed that cleaning agent for mouth cavity has good effect to oral cavity treatment of diseases and prevention, and nontoxic pair of effect.

Describe in detail according to embodiment below.

1, composition is formed:

Composition weight %

Domiphen bromide 0.03

Thymol 0.02

Metronidazole 0.025

Sodium cyclamate 0.1

Mentholum 0.05

Oleum menthae is an amount of

Glycerol 2.54

Ethanol 4.75

The surplus of the above-mentioned percentage ratio of distilled water

Summation 100%

2, compound method: use conventional compound method with water soluble components-domiphen bromide, metronidazole, sweet close element dissolved in distilled water, again with water insoluble and be dissolved in alcoholic acid composition-thymol, Mentholum dissolve with ethanol, merge above-mentioned two solution then, stir, add glycerol again, Oleum menthae stirs, add remaining distilled water again and stir, filtration, packing.

The mouthfeel of the cleaning agent for mouth cavity of manufacturing with above-mentioned prescription is the Herba Menthae cold-type yellow (clear), and is pleasantly sweet.According to user to cleaning agent for mouth cavity mouthfeel different needs, can cleaning agent for mouth cavity be modulated into other odor type according to conventional method, as selecting following oral cavity correctives for use: Oleum menthae, Oleum Caryophylli, Oleum Menthae Rotundifoliae, Oleum Cinnamomi, a kind of in Pingguo essence, flavoring orange essence, the flavoring banana essence etc. also can select for use above-mentioned several combination to make mixing odor type.Adjuvant in this example has been selected molasses element and Mentholum for use, and their rectification effect is more satisfactory, can certainly select saccharin sodium or Folium Stevlae Rebaudianae for use by single.

Claims (1)

1, a kind of cleaning agent for mouth cavity, it is characterized in that: it is made up of following ingredients:

1.1, disinfectant: form by 0.03% domiphen bromide and 0.02% thymol and 0.025% metronidazole;

1.2, be used to correct or the adjuvant of comprehensive disinfection strange smell is selected for use following a kind of at least: molasses element, saccharin sodium, Mentholum, Folium Stevlae Rebaudianae, consumption are 0.1%;

1.3, be used to reduce the irritating adjuvant of disinfectant: 2.54% glycerol;

1.4, an amount of aroma type oral cavity correctives selects for use following a kind of at least: Oleum menthae, Oleum Caryophylli, Oleum Menthae Rotundifoliae, Oleum Cinnamomi, apple essence, flavoring orange essence, flavoring banana essence;

1.5, be used to dissolve the solvent of described disinfectant and adjuvant: 4.75% ethanol and distilled water add to 100%.