CN1331968A - Chinese medicine toothpaste - Google Patents
Chinese medicine toothpaste Download PDFInfo
- Publication number
- CN1331968A CN1331968A CN 01120480 CN01120480A CN1331968A CN 1331968 A CN1331968 A CN 1331968A CN 01120480 CN01120480 CN 01120480 CN 01120480 A CN01120480 A CN 01120480A CN 1331968 A CN1331968 A CN 1331968A
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- supercritical extraction
- chinese medicinal
- toothpaste
- magnolol
- medicinal toothpaste
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Abstract
The Chinese medicine toothpaste contains supercritical extracted magnolol in 0.1-0.5 wt% and supercritical extracted paeonol in 0.1-0.5 wt%. The medicinal components are extract of natural plant material produced through supercritical CO2 extraction and have determined components and high purity. The medicine components have strong bacteriostasis function on oral cavity pathogen, and the toothpaste of the present invention has excellent treating effect on gum bleeding, stomatocase, caries, peridentitis, gingivitis and dentin hypersensitive-ness.
Description
The present invention relates to the toothpaste that daily life is used, particularly contain toothpaste from the natural extract composition.
At present, Chinese medicinal toothpaste kind daily on the market is a lot, and multipotency suppresses the oral cavity noxious bacteria, anti-inflammatory analgesic, acid-proof desensitization, caries prevention, control gingivitis, periodontitis, periodontals such as dental hemorrhage.The composition of its Chinese medicine lotion of toothpaste substrate of present Chinese medicinal toothpaste is much the same, wetting agent by the glycerol of 20-30% or sorbitol etc., the carboxymethyl cellulose of 1-3% is the binding agent of sodium or hydroxyethyl-cellulose etc., the surfactant of the sodium lauryl sulphate of 1-3%, the abrasive of the calcium carbonate of 40-50% or calcium hydrogen phosphate etc.Compositions such as the essence of 1-1.5%, balance of deionized water.The drug effect of Chinese medicinal toothpaste mainly is to determine that by adding the intravital Chinese medicine ingredients of cream the Chinese medicine ingredients in the Chinese medicinal toothpaste is the method effective component extracting from plant, Chinese crude drug with ethanol or decocting in water now.Extract impurity with this traditional method for extracting is too many, and active constituent content is low, and the composition of each batch products is uncertain, causes the drug effect instability.Extract rule more because of decocting in water temperature height with decocting in water extractum, the time is long, the decomposition easily of the effective ingredient in the medical material, oxidation or hydrolysis, and concentration process makes the extractum color burn behind the decocting in water.Add in the toothpaste with such extract, the effect that wants to make toothpaste really bring into play its active drug must strengthen addition, and the color of toothpaste must be very dark like this, influences the mastic outward appearance.
The purpose of this invention is to provide a kind of Chinese medicinal toothpaste, the effective ingredient of medicine derives from natural plants, the extract of supercritical carbon dioxide extraction, composition is determined, the purity height, each batch products drug effect, steady quality, the pure white exquisiteness of made toothpaste outward appearance, oral cavity pathogen there is stronger inhibitory or killing effect, there are good efficacy in dental hemorrhage, oral ulcer, caries prevention, periodontitis, dentin hypersensitiveness.
Technical solution of the present invention is that this Chinese medicinal toothpaste is formed (W/W) by following material
Supercritical extraction magnolol 0.1-0.5%
Supercritical extraction paeonol 0.1-0.5%
Chinese medicinal toothpaste mastic substrate surplus
The above supercritical extraction magnolol is to extract through supercritical extraction process from the plant Cortex Magnoliae Officinalis.
Supercritical extraction magnolol purity of the present invention is more than 80%.
Above supercritical extraction paeonol of the present invention is through supercritical extraction from the plant Cortex Moutan.
Supercritical extraction paeonol purity of the present invention is more than 80%.
Above Chinese medicinal toothpaste mastic matrix group of the present invention becomes (W/W)
Glycerol 20-35%
Sodium carboxymethyl cellulose 1-3%
Sodium lauryl sulphate 1-3%
Calcium carbonate 40-50%
Essence 1-1.5%
The deionized water surplus
The supercritical extraction principle is, some material is gaseous state in supercriticality, and density is similar to liquid, has good solvent property, can be used as solvent and extracts; Also can utilize the character that under subcritical state, is liquid to reach the extraction purpose.The supercritical carbon dioxide extraction isolation technics, it is low to have temperature, without solvent, can separate to greatest extent and the characteristics of the composition of remaining valid, and is described as green isolation technics, is the important means that realizes the modernization of Chinese medicine.Use the supercritical carbon dioxide extraction isolation technics and can isolate effectively Chinese medicine ingredients such as magnolol, paeonol from natural Chinese medicines such as Cortex Magnoliae Officinalis, Cortex Moutan, these Chinese medicine ingredients are analyzed effective content generally more than 85% from purity; It is obvious to analyze drug effect from effect, to suppressing oral cavity noxious bacteria, caries prevention, control periodontal etc. more stable effect is arranged; From analyzing in appearance because the purity height, paler colour, be suitable for as the toothpaste Chinese medicine additive, Yan Zhi Chinese medicinal toothpaste is fully different with traditional Chinese medicinal toothpaste in this way, and modern Chinese medicine toothpaste has possessed medicinal component and content is determined, color is pure white, effect is remarkable, natural safe characteristics.
According to " Chinese medicine modern study and application " record, magnolol has significant antibacterial activity to gram positive bacteria, acid resistance bacterium, yeast-like fungi and filamentous fungi.With streptomycin sulfate, amphotericin B is that lowest concentration of antimicrobial (MIC) test of contrast shows the anti-bacillus subtilis specific activity streptomycin sulfate height of magnolol; Anti-Trichophyton mentagrophytes specific activity amphotericin B height; Anti-Aspergillus niger is active identical with amphotericin B, and the dental caries effect of magnolol is very remarkable, is 6.3 μ g/ml to the minimum inhibitory concentration of caries bacteria, and its antibacterial activity is better than typical antibacterial biological alkali berberine (MIC:50 μ g/ml).And be that analgesic activity is arranged to the record of paeonol.In addition, according to Guangdong Microbes Inst analyzing and testing report record, contain the supercritical carbon dioxide extraction magnolol, the Chinese medicinal toothpaste of the present invention of supercritical extraction paeonol Chinese medicine ingredients, to escherichia coli, staphylococcus aureus sterilizing rate all 〉=90%, so belong to and press down (killing) bacterium more by force and act on.
Modern Chinese medicine toothpaste of the present invention, through close beta, the effect reflection is good, close beta crowd 50 people, crowd's screening is to liking regular dental hemorrhage, oral ulcer and dental caries patient, and the effect observation statistics is as follows:
The effect observation statistical table
| Disease | Number | Produce effects | Effectively | Effective percentage |
| Dental hemorrhage | ????20 | ????15 | ????3 | ????90％ |
| Oral ulcer | ????15 | ????8 | ????4 | ????80％ |
| Dental caries | ????15 | ????7 | ????6 | ????87％ |
Modern Chinese medicine toothpaste of the present invention through clinical experiment, has certain curative effect to periodontitis, gingivitis, dentin hypersensitiveness, and the clinical observation on the therapeutic effect statistics is as follows:
Periodontal clinical efficacy statistical table
| Periodontal | Number | Produce effects | Effectively | Effective percentage |
| Periodontitis | ????39 | ????15 | ????19 | ????87.2％ |
| Gingivitis | ????18 | ????6 | ????9 | ????83.3％ |
| Dentin hypersensitiveness | ????43 | ????14 | ????25 | ????90.7％ |
| Gather | ????100 | ????35 | ????53 | ????88％ |
The clinical efficacy conclusion: periodontals such as periodontitis, gingivitis, dentin hypersensitiveness are had certain curative effect, and effective percentage reaches 88%, and life-time service is to improving the oral environment health, keeping oral health that good efficacy is arranged.
In the existing Chinese medicinal toothpaste mastic matrix components, the wetting agent of traditional common has glycerol, or sorbitol, propylene glycol, Polyethylene Glycol, and the using method of traditional common is singly to use the also use of several combinations.The binding agent of traditional common has sodium carboxymethyl cellulose or hydroxyethyl-cellulose, carrageenan, HANSHENGJIAO, and the using method of traditional common is singly to use, use that also can several combinations.The abrasive of traditional common has calcium carbonate or calcium hydrogen phosphate, calcium pyrophosphate, silicon dioxide, and the using method of traditional common is singly to use, or the use of several combinations.
The advantage of Chinese medicinal toothpaste of the present invention is the extract of the effective ingredient source natural plants supercritical carbon dioxide extraction of medicine, composition is determined, the purity height, each batch products drug effect, steady quality, the pure white exquisiteness of made toothpaste outward appearance, oral cavity pathogen is had strong inhibitory or killing effect, and to dental hemorrhage, oral ulcer, caries prevention has good efficacy.
Below embodiments of the invention are described:
Embodiment one: (following component is W/W)
Glycerol 30%
Sodium carboxymethyl cellulose 1.4%
Sodium lauryl sulphate 1.9%
Calcium carbonate 47%
Supercritical extraction magnolol 0.15%
Supercritical extraction paeonol 0.2%
Essence 1%
The deionized water surplus
Embodiment two (following component is W/W)
Glycerol 15%
Sorbitol 15%
Sodium carboxymethyl cellulose 1.4%
Glucide 0.25%
Sodium lauryl sulphate 1.9%
Calcium carbonate 47%
Supercritical extraction magnolol 0.15%
Supercritical extraction paeonol 0.2%
Essence 1%
The deionized water surplus
Embodiment three: (following component is W/W)
Glycerol 10%
Polyethylene Glycol 10%
Sorbitol 15%
HANSHENGJIAO 0.3%
Sodium carboxymethyl cellulose 0.1%
Glucide 0.21%
Sodium lauryl sulphate 2.2%
Calcium hydrogen phosphate 35%
Silica 1 0%
Supercritical extraction magnolol 0.3%
Supercritical extraction paeonol 0.3%
Essence 1%
The deionized water surplus
Embodiment four: (following component is W/W)
Polyethylene Glycol 15%
Propylene glycol 10%
Sorbitol 10%
Sodium carboxymethyl cellulose 0.9%
Carrageenan 0.4%
Glucide 0.22%
Sodium lauryl sulphate 2.2%
Calcium pyrophosphate 25%
Silica 1 5%
Supercritical extraction magnolol 0.2%
Supercritical extraction paeonol 0.3%
Essence 1%
The deionized water surplus
Claims (6)
1. a Chinese medicinal toothpaste is characterized in that forming (W/W) by following material
Supercritical extraction magnolol 0.1-0.5%
Supercritical extraction paeonol 0.1-0.5%
Chinese medicinal toothpaste mastic substrate surplus
2. a kind of Chinese medicinal toothpaste according to claim 1 is characterized in that the supercritical extraction magnolol is to extract through supercritical extraction process from the plant Cortex Magnoliae Officinalis.
3. a kind of Chinese medicinal toothpaste according to claim 1 and 2 is characterized in that supercritical extraction magnolol purity is more than 80%.
4. a kind of Chinese medicinal toothpaste according to claim 1 is characterized in that the supercritical extraction paeonol is through supercritical extraction from the plant Cortex Moutan.
5. according to claim 1 or 4 described a kind of Chinese medicinal toothpastes, it is characterized in that supercritical extraction paeonol purity is more than 80%.
6. a kind of Chinese medicinal toothpaste according to claim 1 is characterized in that Chinese medicinal toothpaste mastic matrix group becomes (W/W)
Glycerol 20-35%
Sodium carboxymethyl cellulose 1-3%
Sodium lauryl sulphate 1-3%
Calcium carbonate 40-50%
Essence 1-1.5%
The deionized water surplus
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB01120480XA CN1147286C (en) | 2001-07-18 | 2001-07-18 | Chinese medicine toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB01120480XA CN1147286C (en) | 2001-07-18 | 2001-07-18 | Chinese medicine toothpaste |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1331968A true CN1331968A (en) | 2002-01-23 |
| CN1147286C CN1147286C (en) | 2004-04-28 |
Family
ID=4664167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB01120480XA Expired - Lifetime CN1147286C (en) | 2001-07-18 | 2001-07-18 | Chinese medicine toothpaste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1147286C (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766551A (en) * | 2010-03-30 | 2010-07-07 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
| CN101095656B (en) * | 2007-07-19 | 2010-11-03 | 法国医药集团 | Application of Andrographis paniculata in the preparation of tooth cleaning articles and the tooth cleaning articles thereof |
| CN102762219A (en) * | 2010-02-24 | 2012-10-31 | 高露洁-棕榄公司 | Oral care compositions |
| CN102884035A (en) * | 2010-02-25 | 2013-01-16 | 高露洁-棕榄公司 | Synthesis of magnolol and its analogue compounds |
| CN103445977A (en) * | 2013-08-13 | 2013-12-18 | 上海方木精细化工有限公司 | Calcium carbonate type toothpaste |
| US8900644B2 (en) * | 2004-12-22 | 2014-12-02 | Colgate-Palmolive Company | Oral care compositions containing compounds from magnolia and hops extracts |
| US8956592B2 (en) | 2010-02-24 | 2015-02-17 | Colgate-Palmolive Company | Oral care compositions |
| CN104606092A (en) * | 2014-12-30 | 2015-05-13 | 东莞市高明企业服务有限公司 | Toothpaste capable of calming nerves and helping sleep for night use and preparation method thereof |
| CN104940438A (en) * | 2015-06-16 | 2015-09-30 | 方克贵 | Chinese herbal medicine extract and toothpaste for preventing and treating childhood caries, and application of Chinese herbal medicine extract |
| CN105534769A (en) * | 2015-12-22 | 2016-05-04 | 南昌理工学院 | Antibacterial toothpaste containing a baical skullcap root extract product |
| CN106659651A (en) * | 2014-07-21 | 2017-05-10 | 高露洁-棕榄公司 | Abrasive oral care composition |
| CN109364115A (en) * | 2018-12-20 | 2019-02-22 | 扬州倍加洁日化有限公司 | Oral cavity composition and its application containing licorice and Radix Cynanchi Paniculati extract |
| CN113730440A (en) * | 2021-09-14 | 2021-12-03 | 康博士日化集团有限公司 | Antibacterial composition and oral care product containing same |
-
2001
- 2001-07-18 CN CNB01120480XA patent/CN1147286C/en not_active Expired - Lifetime
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8900644B2 (en) * | 2004-12-22 | 2014-12-02 | Colgate-Palmolive Company | Oral care compositions containing compounds from magnolia and hops extracts |
| CN101095656B (en) * | 2007-07-19 | 2010-11-03 | 法国医药集团 | Application of Andrographis paniculata in the preparation of tooth cleaning articles and the tooth cleaning articles thereof |
| US9801940B2 (en) | 2010-02-24 | 2017-10-31 | Colgate-Palmolive Company | Oral care compositions |
| CN102762219A (en) * | 2010-02-24 | 2012-10-31 | 高露洁-棕榄公司 | Oral care compositions |
| CN102762219B (en) * | 2010-02-24 | 2016-05-04 | 高露洁-棕榄公司 | Oral care composition |
| US8956592B2 (en) | 2010-02-24 | 2015-02-17 | Colgate-Palmolive Company | Oral care compositions |
| CN102884035B (en) * | 2010-02-25 | 2016-01-20 | 高露洁-棕榄公司 | The synthesis of magnolol and similar compound thereof |
| CN102884035A (en) * | 2010-02-25 | 2013-01-16 | 高露洁-棕榄公司 | Synthesis of magnolol and its analogue compounds |
| CN101766551A (en) * | 2010-03-30 | 2010-07-07 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
| CN101766551B (en) * | 2010-03-30 | 2012-05-30 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
| CN103445977B (en) * | 2013-08-13 | 2016-05-04 | 四川亿欣新材料有限公司 | Calcium carbonate type toothpaste |
| CN103445977A (en) * | 2013-08-13 | 2013-12-18 | 上海方木精细化工有限公司 | Calcium carbonate type toothpaste |
| CN106659651A (en) * | 2014-07-21 | 2017-05-10 | 高露洁-棕榄公司 | Abrasive oral care composition |
| US10624824B2 (en) | 2014-07-21 | 2020-04-21 | Colgate-Palmolive Company | Abrasive oral care composition |
| CN104606092A (en) * | 2014-12-30 | 2015-05-13 | 东莞市高明企业服务有限公司 | Toothpaste capable of calming nerves and helping sleep for night use and preparation method thereof |
| CN104940438A (en) * | 2015-06-16 | 2015-09-30 | 方克贵 | Chinese herbal medicine extract and toothpaste for preventing and treating childhood caries, and application of Chinese herbal medicine extract |
| CN105534769A (en) * | 2015-12-22 | 2016-05-04 | 南昌理工学院 | Antibacterial toothpaste containing a baical skullcap root extract product |
| CN109364115A (en) * | 2018-12-20 | 2019-02-22 | 扬州倍加洁日化有限公司 | Oral cavity composition and its application containing licorice and Radix Cynanchi Paniculati extract |
| CN109364115B (en) * | 2018-12-20 | 2021-06-18 | 扬州倍加洁日化有限公司 | Oral composition containing licorice extract and paniculate swallowwort root extract and application thereof |
| CN113730440A (en) * | 2021-09-14 | 2021-12-03 | 康博士日化集团有限公司 | Antibacterial composition and oral care product containing same |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1147286C (en) | 2004-04-28 |
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Legal Events
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|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Guangzhou City, Guangdong province 510075 Shuiyin Road No. 17, two Patentee after: Masson Group Co.,Ltd. Address before: Guangzhou City, Guangdong province 510075 Shuiyin Road No. 17, two Patentee before: Guangzhou Meichen Group Co.,Ltd. Address after: Guangzhou City, Guangdong province 510075 Shuiyin Road No. 17, two Patentee after: Guangzhou Meichen Group Co.,Ltd. Address before: Guangzhou City, Guangdong province 510075 Shuiyin Road No. 17, two Patentee before: Guangzhou Meichn Co.,Ltd. |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190912 Address after: 510000 First Floor B1 of Baishuitang 1-2, Huangpu Industrial Avenue, Tianhe District, Guangzhou City, Guangdong Province Patentee after: Dr. Kang Daihua Group Co.,Ltd. Address before: Guangzhou City, Guangdong province 510075 Shuiyin Road No. 17, two Patentee before: Masson Group Co.,Ltd. |
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| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20040428 |