CN106265087A - A kind of root canal flushing liquor and preparation method thereof - Google Patents
A kind of root canal flushing liquor and preparation method thereof Download PDFInfo
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- CN106265087A CN106265087A CN201610848196.9A CN201610848196A CN106265087A CN 106265087 A CN106265087 A CN 106265087A CN 201610848196 A CN201610848196 A CN 201610848196A CN 106265087 A CN106265087 A CN 106265087A
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- flushing liquor
- hypochlorite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/52—Cleaning; Disinfecting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
Abstract
The application belongs to tooth treatment technical field, is specifically related to a kind of root canal flushing liquor and preparation method thereof.This root canal flushing liquor includes each component of following weight portion: amino acid/11 0 20 parts, pH adjusting agent regulation pH to 8 12, thickening agent 38 parts, oxidative active ingredients 40 90 parts, antibacterial auxiliary agent 25 parts, distilled water 1,000 2000 parts, wherein, described oxidative active ingredients includes inorganic constituents hypochlorite and organic principle Chinese medicine extract.The root canal irrigation liquid provided by the application to oral mucosa without any stimulation, and free from extraneous odour, without giving out light fragrance in the case of adding external essence, and there is the bacteriostasis property of excellence.
Description
Technical field
The invention belongs to tooth treatment technical field, be specifically related to a kind of root canal flushing liquor and preparation method thereof.
Background technology
Dental pulp disease and periapical disease are the commonly encountered diseases of the department of stomatology, frequently-occurring disease, and anaerobe is the dominant bacteria in infectious root canal, its
In, gram anaerobe is principal causative flora, and recall rate is up to 98.33% (all second places, " four kinds of root canal irrigation liquid clinics effects
Fruit is evaluated ", " packet header medical college journal " 2007,23 (4): 386).Think after the scholar's research such as KhabbazMG that endotoxin is to cause
The key factor of periapical inflammation recurrent exerbation.Root canal is the treatment dental pulp disease and the first-selection side of periapical disease generally acknowledged at present
Method.
Root canal is typically made up of three big steps: root canal preparation, root canal disinfection, root-canal filling.In a very long time,
Many scholars emphasize root canal disinfection very much.But modern study finds, conventional root canal disinfectant effect is all that superficiality is with temporarily
Time property, therefore root canal disinfection can not be ignored, but can not overemphasize.
Root canal irrigation, as a kind of important method of root canal disinfection, to treating successfully, has very important effect.Root pipe
Flushing can be with sterilization, solubility phase diagram tissue, removes Gen Guannei remnant tissue, fragment and microorganism, lubricates root canal wall；Favorably
In expanding root pipe and reducing instrument fracture chance in root pipe；Make root canal wall soften, contribute to the chemistry preparation of root pipe.So
One of main purpose of sterilization simply root canal irrigation.Preferably Root canal irrigant should possess following four main character: have antibacterial,
Bactericidal action；Solubilized dead pulp tissue；Contribute to the cleaning of root canal system；To periapical tissue avirulence.Former three is
Connect each other, the fine debris in solubility phase diagram tissue, root pipe and dentin chip, contribute to the cleaning of root canal system, subtract
Antibacterial in few root pipe；Slough is removed, the most just reduces the substrate facilitation to bacterial growth.It addition, root Guan Chong
The antibacterial effect of lotion is in addition to the antibacterial characteristics of self, and the ability also removing smear layer with it has relation.
Conventional Root canal irrigant has sodium hypochlorite, metal ion intercalating agent, also has use normal saline, hydrogen peroxide, egg
White lyase, urea peroxide glycerin liquid, chloramine, hibitane, acidic electrolyte bath water, antibiotic etc. are as Root canal irrigant.
The root canal flushing liquor of most common of which is liquor natrii hypochloritis, itself has stronger oxidisability, solubilized dead pulp group
Knit；There is lubrication, contribute to the cleaning of root canal system；To periapical tissue avirulence, there is certain biocompatibility, be mesh
Front optimal flushing liquor.But, owing to liquor natrii hypochloritis has strong oxidizing property, oral cavity mucous membrane tissue is had stronger stimulation
Property, corrosivity and anaphylaxis, oral cavity mucous membrane tissue can be made to produce burn feeling at Clinical practice, even produce chemical burn, therefore
When using clinically, it is necessary to use dental dams.It addition, liquor natrii hypochloritis itself has the heaviest abnormal flavour (bleaching powder
Taste), patient can be made to produce serious discomfort.These all make liquor natrii hypochloritis as the application clinically of dentistry flushing liquor, are subject to
To greatly limiting.
Applicant is in patent application document " a kind of Synergistic diluent for root canal flushing liquor and preparation side thereof before
Method " in by root canal flushing liquor add Synergistic diluent can reduce the effect of root canal toxicity and not affect punching
The bactericidal effect of washing liquid.
Chinese herbal medicine is nature crude drug, and its antibacterial action is typically weak than antibiotic and chemical agent, but Chinese herbal medicine is the most right
Body side effect is little, the most less generation drug resistance, and aerobe and anaerobe are had antibacterial action simultaneously, therefore uses Chinese herbal medicine
Treatment infectious disease has its certain advantage, and the mechanism that certain Chinese herbal treatment infects is complex, medicine the most antibacterial
Effect is often one of considerations of curative effect.Document " experiment screening of Traditional Chinese Medicine Anti root pipe anaerobe " (Chen Hui etc., " modern
Stomatology magazine ", 1993,7 (3): 141-3.) report propolis tincture and can be used for remaining root canal disinfection and action time longer,
Mix application with Radix Et Rhizoma Rhei, antibacterial action is obviously enhanced.
But at present the material (liquor natrii hypochloritis, hydrogen peroxide etc.) with chemical disinfection effect is used in combination with Chinese herbal medicine
The relevant report prepared in root canal flushing liquor is less.
Summary of the invention
The purpose of the application is to provide a kind of root canal flushing liquor, and it has antibacterial, bactericidal action；Solubilized dead pulp
Tissue；Contribute to the cleaning of root canal system；To periapical tissue avirulence.
In order to realize foregoing invention purpose, this application provides a kind of root canal flushing liquor, it includes following weight portion
Each component:
Wherein, described oxidative active ingredients includes inorganic constituents hypochlorite and organic principle Chinese medicine extract.
Preferably, described aminoacid is glycine, alanine, valine, leucine, isoleucine, cysteine, phenylpropyl alcohol
Propylhomoserin, proline, tryptophan, histidine, lysine, glutamic acid, glutamine, arginine, serine, threonine, Radix Asparagi ammonia
At least one in acid, agedoite, methionine and tyrosine.
It is further preferred that described aminoacid is at least one in glycine, cysteine, with agedoite, paddy ammonia
The combination of at least one in amide.Utilize this combination aminoacid can improve flushing liquor to the combination of root pipe slough and molten
Solution ability.
Preferably, described pH adjusting agent is selected from sodium hydroxide, potassium hydroxide, sodium carbonate, sodium phosphate, sodium tartrate and citron
At least one in acid sodium, or its solution.
It is further preferred that described pH adjusting agent is sodium citrate solution, (sodium citrate is molten for polyhydric acylate
Liquid) when making pH adjusting agent, on the one hand can strengthen " stability " of antibacterial auxiliary agent (such as polyhydroxy apatite), i.e. by intermolecular
Interact, make more polyhydroxy apatite rest on root pipe inside and surface；On the other hand Chinese medicine extract can be worked in coordination with
In active component, such as phenolic acids, potentiation.
Preferably, described thickening agent is selected from hydroxypropyl methylcellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, methyl
At least one in the polymer substances such as cellulose, carbomer, hyaluronic acid, hyaluronate sodium and chitosan.
It is further preferred that the combination that described thickening agent is hydroxypropyl methylcellulose, chitosan and sodium carboxymethyl cellulose.
Preferably, at least during described hypochlorite is sodium hypochlorite, postassium hypochlorite, calcium hypochlorite and lithium hypochlorite
Kind；
Described Chinese medicine extract is Cortex Cinnamomi, Radix Et Rhizoma Rhei, Galla Chinensis, the Radix Rehmanniae, the Radix Astragali, Radix Isatidis, Herba Houttuyniae, Artemisia absinihium L, Flos Chrysanthemi Indici
With at least one in Rhizoma Acori Graminei extract.
Wherein, above-mentioned Chinese medicine extract can use the extraction of ordinary skill in the art means to obtain having suppression anaerobe
Active component.Such as, with reference to conventional practices in prior art, such as the document " series of studies of Traditional Chinese Medicine Anti anaerobe: I antioxygen
The screening of the Chinese herbal medicine of bacterium " (" Chinese micro-life set the mind on study impurity ", 1989,1 (2): 5-7.)
It is further preferred that described oxidative active ingredients by hypochlorite and Chinese medicine extract with weight ratio as 1:(3-10)
Combination.In this range, when other condition is identical, the bacteriostasis property of prepared flushing liquor is with hypochlorite or with Chinese medicine extraction
Thing is 4-5 times of the bacteriostasis property of flushing liquor during active component.
It is further preferred that described hypochlorite is sodium hypochlorite and/or postassium hypochlorite；
Described Chinese medicine extract is the extract of Radix Isatidis, Herba Houttuyniae and Flos Chrysanthemi Indici；The preparation method of this Chinese medicine extract
Specifically include following steps:
1) each component is weighed by weight, by Flos Chrysanthemi Indici, Herba Houttuyniae with weight ratio as 1:(5-10) it is placed in volumetric concentration and is
Reflux, extract, 1-3 time in the ethanol water of 80-95%, each 1-3 hour, concentrating under reduced pressure after merging, obtain at 25 DEG C was relative
Density is the extracting solution 1 of 0.8-1.2；
2) with weight ratio as 1:(5-10 after Radix Isatidis being pulverized) it is placed in purified water at 50-65 DEG C ultrasonic 30-60 minute,
Filter, decoct 1-3 hour at filtering residue is placed in 85-95 DEG C, again filter, merge twice filtrate and concentrate, obtain the phase at 25 DEG C
To the extracting solution 2 that density is 0.8-1.2；
3) united extraction liquid 1 and 2, obtains target Chinese medicine extract.
Preferably, the weight ratio of raw material Radix Isatidis, Herba Houttuyniae and Flos Chrysanthemi Indici is 1:(2-8): (4-10)；Further
It is preferably 1:5:5.
Preferably, described antibacterial auxiliary agent is hydroxyapatite or its modified structure.
The modified structure of described hydroxyapatite refer to utilize silane coupler that hydroxyapatite surface is modified or
Carrying out grafting and coating, concrete method of modifying can use ordinary skill in the art means.
Preferably, above-mentioned flushing liquor also includes pigment；Described pigment is food coloring.
Wherein, this application provides the preparation method of a kind of above-mentioned root canal flushing liquor, it specifically comprises the following steps that
Successively the aminoacid of formula ratio, thickening agent, oxidative active ingredients and antibacterial auxiliary agent are added in distilled water, stirring
20-40 minute, add pH adjusting agent regulation pH to 8-12, to obtain final product.
The root canal flushing liquor preparation technology that the application provides is simple, it is not necessary to separately deposited with other component by active component
I.e. having preferable stability, test shows, the flushing liquor that the application provides can deposit 2-3 month.
The root canal flushing liquor that the application provides compared with prior art, has the advantage that
(1) hypochlorite and Chinese medicine extract are combined the flushing liquor being used as oxidative active ingredients prepared and show prominent
Bacteriostasis property, embodiment 2 when the Scavenging activity of the root canal irrigation liquid induced by endotoxin prepared is with hypochlorite for active component
More than 4 times of Scavenging activity of flushing liquor；
Combinations thereof substantially increases the biocidal property of Chinese medicine extract simultaneously, compares single with Chinese medicine extract for activity one-tenth
Divide the flushing liquor (embodiment 6) prepared, hypochlorite and Chinese medicine extract are combined (embodiment 2), the removing energy of induced by endotoxin
Power improves more than 3 times.
(2) the root canal irrigation liquid that the application provides is to oral mucosa without any stimulation, and free from extraneous odour, without adding external perfume (or spice)
Light fragrance is i.e. given out in the case of essence.
(3) flushing liquor that the application provides adds antibacterial auxiliary agent, can preferably oxidative active ingredients " be sticked "
Root tube-surface, by the histone calcification of root tube-surface, is conducive to stoping the further infection of antibacterial.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further elaborated.These embodiments are only in order at purpose of explanation,
And do not limit the scope of the invention and essence.
Embodiment 1
A kind of root canal flushing liquor, it includes each component of following weight portion:
The preparation method of above-mentioned root canal flushing liquor specifically comprises the following steps that
Successively by the histidine of above-mentioned weight portion, sodium carboxymethyl cellulose, sodium hypochlorite, Cortex Cinnamomi extract and polyhydroxy phosphorus
Lime stone is placed in distilled water, stirs 30-40 minute, adds 0.1M sodium hydroxide solution regulation pH to 8, to obtain final product.
Embodiment 2
A kind of root canal flushing liquor, it includes each component of following weight portion:
Wherein, the weight portion of Radix Isatidis, Herba Houttuyniae and Flos Chrysanthemi Indici is 5 parts, 25 parts, 25 parts；
The preparation method of described Radix Isatidis, Herba Houttuyniae and Flos Chrysanthemi Indici extract specifically includes following steps:
1) weigh each component by weight, Flos Chrysanthemi Indici and Herba Houttuyniae are placed in volumetric concentration for 95% with weight ratio for 1:10
Ethanol water in 80 DEG C of reflux, extract, 2 times, each 2 hours, concentrating under reduced pressure after merging, obtaining the relative density at 25 DEG C was
The extracting solution 1 of 1.2；
2) it is placed in purified water at 65 DEG C ultrasonic 60 minutes for 1:10 with weight ratio after Radix Isatidis being pulverized, filters, will filter
Slag is placed at 95 DEG C decoction 1.5 hours, again filters, merges twice filtrate and concentrate, and obtaining the relative density at 25 DEG C is 0.9
Extracting solution 2；
3) united extraction liquid 1 and 2, obtains target Chinese medicine extract.
The preparation method of above-mentioned root canal flushing liquor specifically comprises the following steps that
Successively by the glycine of above-mentioned weight portion, cysteine, agedoite, glutamine, hypromellose, carboxylic first
The extract of base sodium cellulosate, chitosan, sodium hypochlorite, Radix Isatidis, Herba Houttuyniae and Flos Chrysanthemi Indici, polyhydroxy apatite and carmine
Pigment is placed in distilled water, stirs 40 minutes, adds sodium citrate-sodium hydroxide solution regulation pH to 9 and get final product.
Embodiment 3
A kind of root canal flushing liquor, it includes each component of following weight portion:
Wherein, the preparation method of Artemisia absinihium L extract specifically includes following steps:
Take appropriate Artemisia absinihium L crude drug, cross 20 mesh sieves after rinsing, drying, pulverizing, add pure with powder water w/v for 1:2
Changing water, under room temperature, 24h is soaked in stirring, filters, and 4000r/s is centrifuged 5min, takes supernatant, is centrifuged 2 times altogether.Supernatant freezing is done
Dry, at 60 DEG C of gained dry powder, dried 4 DEG C of cold preservations are standby.
The preparation method of above-mentioned root canal flushing liquor specifically comprises the following steps that
Successively by the glycine of above-mentioned weight portion, proline, lysine, carbomer, sodium hypochlorite, 30% hydrogen peroxide, hardship
Artemisiae argyi extract, it is placed in distilled water through polyhydroxy apatite modified for coupling agent KH-550 and carmine pigment, stirs 35 minutes,
Add 0.3M sodium radio-phosphate,P-32 solution regulation pH to 8.2, to obtain final product.
Embodiment 4
A kind of root canal flushing liquor, it includes each component of following weight portion:
Wherein, the preparation method of the extract of Radix Isatidis, Herba Houttuyniae and Flos Chrysanthemi Indici is with embodiment 2；
The preparation method of above-mentioned root canal flushing liquor specifically comprises the following steps that
Carrying arginine, hyaluronic acid, calcium hypochlorite, Radix Isatidis, Herba Houttuyniae and the Flos Chrysanthemi Indici of above-mentioned weight portion successively
Take thing, polyhydroxy apatite, carmine pigment and essence to be placed in distilled water, stir 35 minutes, add 0.1M potassium hydroxide molten
Liquid regulation pH to 12, to obtain final product.
Embodiment 5
A kind of root canal flushing liquor, it includes each component of following weight portion:
The preparation method of above-mentioned root canal flushing liquor is with embodiment 2.
Embodiment 6
A kind of root canal flushing liquor, it includes each component of following weight portion:
Wherein, the preparation method of the extract of Radix Isatidis, Herba Houttuyniae and Flos Chrysanthemi Indici and the preparation method of root canal flushing liquor
With embodiment 2.
Embodiment 7 (oral mucosa irritation test)
Experimental group: sample in Example 1-6, dips a little with cotton swab, puts on oral mucosa, wash with clear water after 1min
Observe after going；
Matched group: take sodium hypochlorite flushing liquor and distilled water mixed in equal amounts uniformly after, operate with method.
Experimental result is shown in Table 1.
The oral mucosa irritation test of the root canal irrigation liquid that table 1 embodiment 1-6 provides
Result of the test shows, the root canal flushing liquor that embodiment of the present invention 1-6 provides is in the situation the most additionally adding essence
Under, i.e. there is light fragrance；To oral mucosa nonirritant, corrosivity.
Embodiment 8 (test of pesticide effectiveness)
Randomly choose the medical out-patient of oral medicine, age 18-45 year, each 40 of Qi Zhongnan, female patient.Screening
Standard: the Upper Anterior Teeth of the most single pipe；2. clinical and x-ray inspection is diagnosed as chronic periapical periodontitis.Exclusion standard: 1. suffer from tooth and do not carry out
Root canal；2. antibiotic was not taken in the recent period.
Test method: standard compliant tooth of suffering from is randomly divided into 8 groups, and wherein matched group 1 all uses in root canal preparation
0.9% normal saline flushing root pipe；The hydrogen peroxide solution that matched group 2 all uses weight concentration to be 3% in root canal preparation rinses
Root pipe；The flushing liquor that experimental group 1-6 prepares by embodiment 1-6 respectively rinses root pipe.
After each group patient the most aseptically opens marrow, extirpation of pulp, inject baterial endotoxin test water in Xiang Genguan, through light
Insert an aseptic spill after sliding broach agitation, be put immediately into after taking-up in the apyrogeneity test tube filling baterial endotoxin test water,
Adding tachypleus amebocyte lysate the most afterwards, mix measurement endotoxin content in rearmounted BET-72 bacteria endotoxin detector, result is for rinsing
Front endotoxin content.Suffer from endotoxic content after tooth measures flushing by same method after eight kinds of liquid wash for 8 groups, measure
Result such as table 2 below.
Before and after the root canal flushing liquor that table 2 embodiment 1-6 prepares rinses, root pipe endotoxin content changes
By above-mentioned result of the test it can be seen that compared with matched group (3% hydrogen peroxide), utilize the root canal that the application provides
After flushing liquor rinses, can substantially reduce the endotoxin in root pipe, and the flushing liquor that embodiment 2 provides removes endotoxic effect
Best.It is single to use a kind of composition (inorganic or organic) to make during active component 4-5 times of effect.
Above-described embodiment is only used as explaining the purpose of the present invention, and the scope of the present invention is not limited.Skill to this area
The amendment made for art personnel is apparent from, and the present invention is only limited by scope.
Claims (10)
1. a root canal flushing liquor, it includes each component of following weight portion:
Wherein, described oxidative active ingredients includes inorganic constituents hypochlorite and organic principle Chinese medicine extract.
Flushing liquor the most according to claim 1, wherein, described aminoacid be glycine, alanine, valine, leucine,
Isoleucine, cysteine, phenylalanine, proline, tryptophan, histidine, lysine, glutamic acid, glutamine, essence ammonia
At least one in acid, serine, threonine, aspartic acid, agedoite, methionine and tyrosine；Preferably, described amino
Acid is the combination of at least one at least one in glycine, cysteine, with agedoite, glutamine.
Flushing liquor the most according to claim 1, wherein, described pH adjusting agent is selected from sodium hydroxide, potassium hydroxide, carbonic acid
At least one in sodium, sodium phosphate, sodium tartrate and sodium citrate, or its solution；
Preferably, described pH adjusting agent is sodium citrate solution.
Flushing liquor the most according to claim 1, wherein, described thickening agent be hydroxypropyl methylcellulose, carboxymethyl cellulose,
At least one in sodium carboxymethyl cellulose, methylcellulose, carbomer, hyaluronic acid, hyaluronate sodium and chitosan；
Preferably, described thickening agent is the combination of hydroxypropyl methylcellulose, chitosan and sodium carboxymethyl cellulose.
Flushing liquor the most according to claim 1, wherein, described hypochlorite is sodium hypochlorite, postassium hypochlorite, calcium hypochlorite
With at least one in lithium hypochlorite；
Described Chinese medicine extract is Cortex Cinnamomi, Radix Et Rhizoma Rhei, Galla Chinensis, the Radix Rehmanniae, the Radix Astragali, Radix Isatidis, Herba Houttuyniae, Artemisia absinihium L, Flos Chrysanthemi Indici and stone
At least one in Rhizoma Acori Graminei extract.
Flushing liquor the most according to claim 5, wherein, the weight ratio of described hypochlorite and Chinese medicine extract is 1:(3-
10)；Preferably, described hypochlorite is sodium hypochlorite and/or postassium hypochlorite.
Flushing liquor the most according to claim 5, wherein, described Chinese medicine extract is Radix Isatidis, Herba Houttuyniae and Flos Chrysanthemi Indici
Extract；
The preparation method of this Chinese medicine extract specifically includes following steps:
1) each component is weighed by weight, by Flos Chrysanthemi Indici, Herba Houttuyniae with weight ratio as 1:(5-10) it is placed in volumetric concentration as 80-
Reflux, extract, 1-3 time in the ethanol water of 95%, each 1-3 hour, concentrating under reduced pressure after merging, obtain the relative density at 25 DEG C
Extracting solution 1 for 0.8-1.2；
2) with weight ratio as 1:(5-10 after Radix Isatidis being pulverized) it is placed in purified water at 50-65 DEG C ultrasonic 30-60 minute, mistake
Filter, decocts 1-3 hour at filtering residue is placed in 85-95 DEG C, again filters, merge twice filtrate and concentrate, and obtain at 25 DEG C is relative
Density is the extracting solution 2 of 0.8-1.2；
3) united extraction liquid 1 and 2, obtains target Chinese medicine extract.
Flushing liquor the most according to claim 7, wherein, the weight ratio of described raw material Radix Isatidis, Herba Houttuyniae and Flos Chrysanthemi Indici is
1:(2-8): (4-10)；It is preferably 1:5:5.
Flushing liquor the most according to claim 1, wherein, described antibacterial auxiliary agent is hydroxyapatite or its modified structure.
10. the method preparing root canal flushing liquor according to any one of claim 1-9, it specifically comprises the following steps that
Successively the aminoacid of formula ratio, thickening agent, oxidative active ingredients and antibacterial auxiliary agent are added in distilled water, stir 20-40
Minute, add pH adjusting agent regulation pH to 8-12, to obtain final product.
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