CN100998543A - Oral cavity root canal sealant and its preparing method - Google Patents
Oral cavity root canal sealant and its preparing method Download PDFInfo
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- CN100998543A CN100998543A CNA2007100627111A CN200710062711A CN100998543A CN 100998543 A CN100998543 A CN 100998543A CN A2007100627111 A CNA2007100627111 A CN A2007100627111A CN 200710062711 A CN200710062711 A CN 200710062711A CN 100998543 A CN100998543 A CN 100998543A
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- root canal
- oral cavity
- root
- calcium hydroxide
- iodoform
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Abstract
A medicine for enclosing the oral root-canal in order to treat odentopathy is proportionally prepared from calcium hydroxide, formene triiode, methyl cellulose and siloxane. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of oral cavity root canal sealant and preparation method thereof.
Background technology
Toothache is a kind of common frdquently encountered disease, and prior art is many can't fundamentally treat, and therefore often shows as outbreak repeatedly, and the method for having at last take to have tooth pulled out solves.Risen a kind of new Therapeutic Method---root canal in recent years,, ill tooth had thoroughly been treated, and generally can not recur after the healing by the part damage and the downright bad root pipe of ill tooth are repaired or blocked.Root canal is adapted to dental pulp disease and periapical disease.
Present domestic intracanal medicament exists that sterilization property is weak, easy shortcoming hypersensitive more, though and external intracanal medicament Disinfection Effect is better, its price is comparatively expensive, brings very big financial burden for patient's treatment.
Summary of the invention
In order further to improve the effect of root canal, solve present clinical root canal mortality height, the heavy difficult problem of treatment infectious-related complication, and improve the success rate of root canal, and break the quagmire that the intracanal medicament material relies on import, the invention provides a kind of oral cavity root canal sealant and preparation method thereof.
For achieving the above object, technical scheme of the present invention is achieved in that
The invention provides a kind of oral cavity root canal sealant, its active component and parts by weight are as follows:
Calcium hydroxide 150-220, iodoform 130-180,
Methylcellulose 50-150, siloxanes 100-200.
As optimization, oral cavity root canal sealant provided by the invention, its active component and parts by weight are as follows:
Calcium hydroxide 150-220, iodoform 130-180,
Methylcellulose 50-150, siloxanes 100-200,
Zirconium oxide 30-60, nanometer hydroxyapatite 30-60.
As optimization, oral cavity root canal sealant provided by the invention, its active component and parts by weight are as follows:
Calcium hydroxide 200, iodoform 150,
Methylcellulose 80, siloxanes 150,
Zirconium oxide 40, nanometer hydroxyapatite 50.
The present invention also provides the preparation method of above-mentioned oral cavity root canal sealant:
Each component of the described amount of weighing, mixed grinding.
Oral cavity root canal sealant provided by the present invention has in use reduced side effect, and the wound face infection rate is low, and healing is fast.
The specific embodiment
Adopt the synthetic calcium hydroxide composite of duplicate rows celestial body mill technology, prepare compound tube material of calcium hydroxide by ball milling.
Embodiment 1:
Present embodiment provides a kind of oral cavity root canal sealant, and its active component and parts by weight are as follows:
Calcium hydroxide 150, iodoform 180,
Methylcellulose 50, siloxanes 200.
Preparation method is as follows:
The methylcellulose of the described amount of weighing is put into ball grinder, and the alumina balls mix homogeneously with jar interior diameter 15mm and diameter 25mm is fixed on the ball mill, grinds 24 hours with the frequency that per minute 90 changes.The calcium hydroxide, iodoform and the siloxanes that add described amount successively ground 48 hours with the frequency that per minute 120 changes, and crossed 150 mesh sieves.
The using method of oral cavity root canal sealant that present embodiment provides is as follows:
1) dental pulp periapical inflammation is opened marrow, takes off the marrow top, and the extirpation of pulp root is used for root canal disinfection after expanding.
2) pick 5g left and right sides product of the present invention with the spiral plugger, slowly screw in the root pipe, seal temporarily with zinc oxide then, envelope two weeks of medicine.
3) remove zinc oxide,, all remove root-canal filling up to calcium hydroxide with the irrigation with syringe root pipe that contains normal saline.
Embodiment 2:
Present embodiment provides a kind of oral cavity root canal sealant, and its active component and parts by weight are as follows:
Calcium hydroxide 220, iodoform 130,
Methylcellulose 150, siloxanes 100.
Preparation method is as follows:
The methylcellulose of the described amount of weighing is put into ball grinder, and the alumina balls mix homogeneously with jar interior diameter 15mm and diameter 25mm is fixed on the ball mill, grinds 24 hours with the frequency that per minute 90 changes.The calcium hydroxide, iodoform and the siloxanes that add described amount successively ground 48 hours with the frequency that per minute 120 changes, and crossed 150 mesh sieves.
The using method of oral cavity root canal sealant that present embodiment provides is as follows:
1) dental pulp periapical inflammation is opened marrow, takes off the marrow top, and the extirpation of pulp root is used for root canal disinfection after expanding.
2) pick 5g left and right sides product of the present invention with the spiral plugger, slowly screw in the root pipe, seal temporarily with zinc oxide then, envelope two weeks of medicine.
3) remove zinc oxide,, all remove root-canal filling up to calcium hydroxide with the irrigation with syringe root pipe that contains normal saline.
Embodiment 3:
Present embodiment provides a kind of oral cavity root canal sealant, and its active component and parts by weight are as follows:
Calcium hydroxide 200, iodoform 150,
Methylcellulose 80, siloxanes 150.
Preparation method is as follows:
The methylcellulose of the described amount of weighing is put into ball grinder, and the alumina balls mix homogeneously with jar interior diameter 15mm and diameter 25mm is fixed on the ball mill, grinds 24 hours with the frequency that per minute 90 changes.The calcium hydroxide, iodoform and the siloxanes that add described amount successively ground 48 hours with the frequency that per minute 120 changes, and crossed 150 mesh sieves.
The using method of oral cavity root canal sealant that present embodiment provides is as follows:
1) dental pulp periapical inflammation is opened marrow, takes off the marrow top, and the extirpation of pulp root is used for root canal disinfection after expanding.
2) pick 5g left and right sides product of the present invention with the spiral plugger, slowly screw in the root pipe, seal temporarily with zinc oxide then, envelope two weeks of medicine.
3) remove zinc oxide,, all remove root-canal filling up to calcium hydroxide with the irrigation with syringe root pipe that contains normal saline.
Embodiment 4:
Present embodiment provides a kind of oral cavity root canal sealant, and its active component and parts by weight are as follows:
Calcium hydroxide 220, iodoform 130,
Methylcellulose 150, siloxanes 100,
Zirconium oxide 60, nanometer hydroxyapatite 30.
Preparation method is as follows:
The methylcellulose of the described amount of weighing is put into ball grinder, and the alumina balls mix homogeneously with jar interior diameter 15mm and diameter 25mm is fixed on the ball mill, grinds 24 hours with the frequency that per minute 90 changes.The calcium hydroxide, iodoform, siloxanes, zirconium oxide and the nanometer hydroxyapatite that add described amount successively ground 48 hours with the frequency that per minute 120 changes, and crossed 150 mesh sieves.
The using method of oral cavity root canal sealant that present embodiment provides is as follows:
1) dental pulp periapical inflammation is opened marrow, takes off the marrow top, and the extirpation of pulp root is used for root canal disinfection after expanding.
2) pick 5g left and right sides product of the present invention with the spiral plugger, slowly screw in the root pipe, seal temporarily with zinc oxide then, envelope two weeks of medicine.
3) remove zinc oxide,, all remove root-canal filling up to calcium hydroxide with the irrigation with syringe root pipe that contains normal saline.
Embodiment 5:
Present embodiment provides a kind of oral cavity root canal sealant, and its active component and parts by weight are as follows:
Calcium hydroxide 150, iodoform 180,
Methylcellulose 50, siloxanes 200,
Zirconium oxide 30, nanometer hydroxyapatite 60.
Preparation method is as follows:
The methylcellulose of the described amount of weighing is put into ball grinder, and the alumina balls mix homogeneously with jar interior diameter 15mm and diameter 25mm is fixed on the ball mill, grinds 24 hours with the frequency that per minute 90 changes.The calcium hydroxide, iodoform, siloxanes, zirconium oxide and the nanometer hydroxyapatite that add described amount successively ground 48 hours with the frequency that per minute 120 changes, and crossed 150 mesh sieves.
The using method of oral cavity root canal sealant that present embodiment provides is as follows:
1) dental pulp periapical inflammation is opened marrow, takes off the marrow top, and the extirpation of pulp root is used for root canal disinfection after expanding.
2) pick 5g left and right sides product of the present invention with the spiral plugger, slowly screw in the root pipe, seal temporarily with zinc oxide then, envelope two weeks of medicine.
3) remove zinc oxide,, all remove root-canal filling up to calcium hydroxide with the irrigation with syringe root pipe that contains normal saline.
Embodiment 6:
Present embodiment provides a kind of oral cavity root canal sealant, and its active component and parts by weight are as follows:
Calcium hydroxide 200, iodoform 150,
Methylcellulose 80, siloxanes 150,
Zirconium oxide 40, nanometer hydroxyapatite 50.
Preparation method is as follows:
The methylcellulose of the described amount of weighing is put into ball grinder, and the alumina balls mix homogeneously with jar interior diameter 15mm and diameter 25mm is fixed on the ball mill, grinds 24 hours with the frequency that per minute 90 changes.The calcium hydroxide, iodoform, siloxanes, zirconium oxide and the nanometer hydroxyapatite that add described amount successively ground 48 hours with the frequency that per minute 120 changes, and crossed 150 mesh sieves.
The using method of oral cavity root canal sealant that present embodiment provides is as follows:
1) dental pulp periapical inflammation is opened marrow, takes off the marrow top, and the extirpation of pulp root is used for root canal disinfection after expanding.
2) pick 5g left and right sides product of the present invention with the spiral plugger, slowly screw in the root pipe, seal temporarily with zinc oxide then, envelope two weeks of medicine.
3) remove zinc oxide,, all remove root-canal filling up to calcium hydroxide with the irrigation with syringe root pipe that contains normal saline.
Use the oral cavity root canal sealant of the various embodiments described above preparation, in the case of treatment, treatment cycle is short, and infection rate and all reductions greatly of relapse rate.
Calcium hydroxide has strong basicity, and cell membrane and protein structure generation destruction to antibacterial cause the lethal effect to antibacterial; Can make the protein denaturation hydrolysis,, help cleaning the root pipe so can dissolve slough in the root pipe; Can in and the acidic materials that produced of inflammation, thereby reduce the generation of emergency case (IAE) during the root canal.It has convergence, oozes out for diminishing inflammation and the good effect that eases the pain.Calcium hydroxide can also make the root tip uptake zone new cementum occur and serve as a contrast with osteoblastic new bone.People such as Stuart and Gu Lian etc. discover that all calcium hydroxide is significantly higher than formaldehyde cresol formocresol to the antibiotic property of common pathogen in the infectious root canal, and the tissue irritation of formaldehydeless cresol.
Quote calcium hydroxide in the root-canal filling substrate, it has the obvious suppression effect to Streptococcus mutans, gingiva bacteroid etc., the endotoxin of energy degradation of cell; The healing of the pulp tissue of promotion and periapical tissue is arranged, reduce and eliminate periapical and ooze out, promote the mineralization of tissue.
The antibiotic that is used for the root canal filling material treatment mainly contains erythromycin series, Tetracyclines and cephalosporins medicine, and they mainly play certain inhibitory action to gram-bacteria.But anaphylaxis is the topmost side effect of this class medicine.We replace this class medicine with iodoform.
The iodoform that is used for root canal filling material makes non-water-soluble hydrophobic solid.When iodoform runs into the product of alcohol, ether, fat and some antibacterial, slowly decompose the generation free-iodine, thereby produce bactericidal action, and make the bacterial product oxidation.Oozing out of suppuration wound surface has significant quantities of fat class material in the product, can impel the release free-iodine, so iodoform is good disinfectant and deodorizer to wound, disinfective action is lasting.Iodoform has no stimulation to tissue, can reduce the exudate of wound surface, and promotes its absorption, makes the wound surface drying.And can make the granulation tissue growth, promote wound healing.
It is barium sulfate that material is penetrated in resistance in the tradition root canal filling material.The nanometer ZrO2 that we adopted is that its particle diameter is 0～0.6 μ m through the stable cubic phase ZrO2 of Y2O3.Usually it is small to be applied in the nano zircite particle size, is stable oxide very, has acidproof, alkaline-resisting, corrosion-resistant, resistance and high temperature resistance property, is a kind of new material that is applied to oral environment.With nano zircite as an alternative the resistance of barium sulfate penetrate material, with the situation of barium sulfate same amount under, can reach effect above the resistance X ray of barium sulfate, improved the biocompatibility of material largely.
Added acicular nano-hydroapatite particles in matrix components, its particle diameter is 80～100nm.Hydroxyapatite has excellent biological compatibility, and the physiology substrate that is fit to new bone apposition can be provided, and induces inostosis, stimulates the surrounding bone tissue regeneration, and the cementum deposition, and the sealing apical foramen of tooth quickens the diseased region healing, and root fills and can not be organized absorption.Nanometer hydroxyapatite is the hydroxyapatite of nanorize, compares with conventional hydroxyapatite, and nanometer hydroxyapatite toughness and physical and mechanical property all strengthen greatly, and biocompatibility and biological activity are good than the former.And nanometer hydroxyapatite (HA) all has inhibitory action to the growth and breeding of Streptococcus mutans, Streptococcus sanguis, actinomyces viscosus, and Streptococcus sobrinus, porphyromonas gingivalis are had the growth of promotion effect.
In addition, methylcellulose is excipient preferably.Siloxanes can provide the composite good mobility.
The above is preferred embodiment of the present invention only, is not to be used to limit protection scope of the present invention.
Claims (4)
1. an oral cavity root canal sealant is characterized in that, active component and parts by weight are as follows:
Calcium hydroxide 150-220, iodoform 130-180,
Methylcellulose 50-150, siloxanes 100-200.
2. oral cavity root canal sealant according to claim 1 is characterized in that, active component and parts by weight are as follows:
Calcium hydroxide 150-220, iodoform 130-180,
Methylcellulose 50-150, siloxanes 100-200,
Zirconium oxide 30-60, nanometer hydroxyapatite 30-60.
3. oral cavity root canal sealant according to claim 2 is characterized in that, active component and parts by weight are as follows:
Calcium hydroxide 200, iodoform 150,
Methylcellulose 80, siloxanes 150,
Zirconium oxide 40, nanometer hydroxyapatite 50.
4. the preparation method of any described oral cavity root canal sealant of claim 1-3:
The active component of the described amount of weighing, mixed grinding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710062711A CN100998543B (en) | 2007-01-15 | 2007-01-15 | Oral cavity root canal sealant and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710062711A CN100998543B (en) | 2007-01-15 | 2007-01-15 | Oral cavity root canal sealant and its preparing method |
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| CN100998543A true CN100998543A (en) | 2007-07-18 |
| CN100998543B CN100998543B (en) | 2010-05-26 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265087A (en) * | 2016-09-22 | 2017-01-04 | 武汉伢典生物科技有限公司 | A kind of root canal flushing liquor and preparation method thereof |
| CN106377433A (en) * | 2016-08-31 | 2017-02-08 | 河南科技大学 | Anti-microbial root canal filling material and preparation method thereof |
| CN108785105A (en) * | 2018-06-28 | 2018-11-13 | 吉林省登泰克牙科材料有限公司 | A kind of calcium hydroxide root canal deviation composition and preparation method thereof |
| CN114903796A (en) * | 2022-03-17 | 2022-08-16 | 西北民族大学 | Oral root canal sealing medicine and preparation method thereof |
-
2007
- 2007-01-15 CN CN200710062711A patent/CN100998543B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106377433A (en) * | 2016-08-31 | 2017-02-08 | 河南科技大学 | Anti-microbial root canal filling material and preparation method thereof |
| CN106265087A (en) * | 2016-09-22 | 2017-01-04 | 武汉伢典生物科技有限公司 | A kind of root canal flushing liquor and preparation method thereof |
| CN108785105A (en) * | 2018-06-28 | 2018-11-13 | 吉林省登泰克牙科材料有限公司 | A kind of calcium hydroxide root canal deviation composition and preparation method thereof |
| CN114903796A (en) * | 2022-03-17 | 2022-08-16 | 西北民族大学 | Oral root canal sealing medicine and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN100998543B (en) | 2010-05-26 |
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