CN103340799B - Application of spilantes acmella extract in preparation of mouth care materials - Google Patents
Application of spilantes acmella extract in preparation of mouth care materials Download PDFInfo
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- CN103340799B CN103340799B CN201310294903.0A CN201310294903A CN103340799B CN 103340799 B CN103340799 B CN 103340799B CN 201310294903 A CN201310294903 A CN 201310294903A CN 103340799 B CN103340799 B CN 103340799B
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Abstract
The invention discloses a kind of application of spilantes acmella extract in preparation of mouth care materials, relate to oral care implement technical field, i.e. in the technique prepare oral care implement using Herba Cancriniae lasiocarpae extract as promoting the production of body fluid, antiinflammatory and analgesic active component add in oral care implement, the oral care implement of present invention oral care implement of the present invention in preparation process adds gold button extract in preparation process and has promotion salivation as the raw material of natural plant active component, alleviate xerostomia symptom, suppression gingivitis, alleviate dental pain, diabetes patient oral cavity ill symptoms can be improved well, also can play prevention for ordinary consumer and safeguard the effect of oral cavity total health.
Description
Technical field
The present invention relates to oral care implement technical field, especially a kind of Herba Cancriniae lasiocarpae extract is used in preparation mouth care
Application in product.
Background technology
Oral care implement is cleaning indispensable in people's daily life and health product, and this series products kind is numerous
Many, including toothpaste, dentifrice, collutory, chewing gum, oral spray etc., it is mainly used in keeping oral cavity and cleaning of teeth, promotion mouth
Gas is pure and fresh, nurse gingiva, safeguard oral cavity good environment etc..In recent years, the Chinese herb medicine that natural drug particularly China is traditional is made
It is applied in oral care implement solve related oral problem for active component, becomes the focus in market.
Substantially everyone can run into oral problem, if not prevented and controlling, is good for by the health of harm people
Health.Relevant information shows that China's kinsfolk's caries prevalence rate is 52.05%, and dental caries mean is 1.76, and gingivitis prevalence is
16.05%, dental calculus recall rate is 39.35%, and periodontal disease prevalence is 4.43% in early days, and late period, periodontal disease prevalence was
1.73%.The report display of Second National oral health epidemiological survey, in China child of 12 years old, periodontal is unhealthy
Up to 70%, in adult and old people, have the most up to the 90% and 99% of gingival atrophy phenomenon.Ministry of Public Health is announced
Whole nation third time oral health epidemiological survey result shows, the adult of China up to 97% has oral health issue.
Mouthful the most very thirsty, gingivitis is the oral cavity ill symptoms that diabetes patient is common.Diabetes are that one is global often
See disease, frequently-occurring disease, have a strong impact on people healthy, all can increase a lot of diabetics newly every year all over the world.According to international sugar
The statistics display of sick alliance, ends 2007, and whole world diabetics is about 2.46 hundred million people, existing about 24,000,000 patient of diabetes of the U.S.
Person, patient numbers increased more than 300 ten thousand in past 2 years, meanwhile, separately has 57,000,000 Americans to be in the edge of having diabetes.
China there are about 40,000,000 diabeticss, and Europe has 53,000,000 populations to suffer from diabetes.There are some researches show the old age at over-65s
In people, sickness rate is up to 18.4%.Diabetics is up to 87.3% with oral disease person simultaneously, about normal person oral cavity disease
2～3 times of patient.Diabetics due to many reasons such as xerostomia, salivation are few, oral cavity often have xerostomia, decayed tooth,
The problems such as concurrent gingivitis periodontitis, red swelling of gingiva are hemorrhage occur.
Summary of the invention
The problem that the present invention solves is to provide application of spilantes acmella extract in preparation of mouth care materials scheme, this
Oral cavity nursing health products have significantly promote the production of body fluid, antiinflammatory and analgesic activity.
The application of spilantes acmella extract in preparation of mouth care materials scheme of the present invention is exactly in preparation mouth care
In the technique of articles for use using Herba Cancriniae lasiocarpae extract as promoting the production of body fluid, the active component of antiinflammatory and analgesic activity join toothpaste and collutory
Deng in oral care implement.
In technique scheme, more specifically scheme is it may also is that described Herba Cancriniae lasiocarpae extract is in preparing toothpaste technique
As promoting the production of body fluid, antiinflammatory and the raw material of analgesic activity.
Further: described Herba Cancriniae lasiocarpae extract percentage by weight in total mastic of toothpaste is 0.1%～5%.
Further: described Herba Cancriniae lasiocarpae extract in preparing collutory technique as promoting the production of body fluid, antiinflammatory and analgesic activity
Raw material.
Further: described Herba Cancriniae lasiocarpae extract percentage by weight in collutory raw material is 0.1%～5%.
Herba Cancriniae lasiocarpae described in the present invention, has another name called Spilanthes acmella, belongs to the plant of Spilanthes Jacq for Compositae Herba Cancriniae lasiocarpae, point
It is distributed in subtropical and tropical zones, wherein Southwestern China portion to Taiwan pan button S. acmella(L.) Murr. etc. 2 kinds.Gold
Be grown in the humid area near lake, pool and sewage discharge in the case of button is natural, plant height typically 40～60 centimetres it
Between.They have plenty of stolon growth, have plenty of erect stern growth.Leaf has plenty of triangle, has plenty of lanceolar, has dentation
Or complete limb.Fresh idea is yellow, conical or avette, long handle, Dan Sheng.Root length and thin, also can be from Stoloniferous herb
Tuberosity at longer, the head of some Herba Cancriniae lasiocarpae has wine-colored speckle.Their seed is little, in grey black.This genus is planted
Thing grows in the torrid areas of fertile soil throughout the year.The leaf of Herba Cancriniae lasiocarpae and headdress flower (head inflorescence) becoming containing a kind of analgesic
Point, can be used to alleviate the pain of tooth, be therefore otherwise known as Herba monochasmatis.Herba Cancriniae lasiocarpae button alcohol containing gold (C14H23NO), has rush
Enter the effect of salivation.In Cameroon, Herba Cancriniae lasiocarpae is used for treating venom and treatment of arthritis, rheumatism；In Germany,
Herba Cancriniae lasiocarpae extract is used for treating pain or scratch.
The preparation technology extracting the Herba Cancriniae lasiocarpae extracts such as affinine from Herba Cancriniae lasiocarpae plant provided by the present invention include with
Lower step:
1, take Chinese medicine Herba Cancriniae lasiocarpae medical material, be cut into 1～2cm segment；
2, at 30 DEG C～90 DEG C, with 3～5 times 30%～99% ethanol, backflow carries 2～8h, reflux, extract, 3～5 times；
3, filtrate is under the conditions of low temperature≤50 DEG C, and decompression recycling ethanol obtains Herba Cancriniae lasiocarpae extract.
Oral cavity nursing health products in the present invention is to be applied to wherein with the form of single medicinal material by Chinese medicine gold button.
The oral care implement of the present invention adds gold button extract as natural plant active component in preparation process
Raw material have promotion salivation, alleviate xerostomia symptom, suppress gingivitis, alleviate dental pain, can change well
Kind diabetes patient oral cavity ill symptoms, also can play prevention and safeguard the effect of oral cavity total health for ordinary consumer.
Detailed description of the invention
Below in conjunction with example, the invention will be further described, and in following examples, involved percentage ratio is unless another
It is described, is all calculated in weight percent:
Embodiment 1～6: gold button extract application in toothpaste
Toothpaste constitutive material in embodiment 1 to 6 and weight percent content such as following table:
The preparation method of toothpaste in embodiment 1:
Lotion of toothpaste can use the one-step method cream production technology of conventional dentifrices to make: mix agitation phases finally, throws
Enter the Herba Cancriniae lasiocarpae extract measured, to keep the Chinese traditional medicine biology activity of optimum, after middle control sampling detection is qualified, make finished product.Tooth
Cream meets GB GB8372 and QB2966 standard-required.
The production technology of embodiment 2-embodiment 6 is with reference to embodiment 1.
Embodiment 7-12: gold button extract application in collutory.
Collutory constitutive material in embodiment 7 to 12 and weight percent content such as following table:
The preparation method of collutory in embodiment 7:
Use existing collutory production technology, mix agitation phases finally, put into the Herba Cancriniae lasiocarpae extract measured, with
Keep optimum Chinese traditional medicine biology activity.Collutory meets QB/T2945 standard-required.
The production technology of embodiment 7-embodiment 12 is with reference to embodiment 7.
One, the acute toxicity testing of Herba Cancriniae lasiocarpae extract
To healthy mice medicine once abdominal cavity injection, observing 7 days, record variable concentrations respectively organizes dead animal number.By simplifying
Probit calculates: LD50=50.03 ± 6.35mg/Kg (confidence interval 0.95).Illustrate that Herba Cancriniae lasiocarpae extract toxicity is low, peace
Entirely.
Two, containing the analgesic experiment of Herba Cancriniae lasiocarpae extract toothpaste
Experimental technique is writhing method, the writhing response average of medication group is compared with blank group, carries out t inspection between two groups
Test, and calculate analgesia percentage rate.The results are shown in Table 1.
Table 1 test sample (containing Herba Cancriniae lasiocarpae extract) on the statistical result of the impact of chemical substance (glacial acetic acid) induced pain (x ±
S,n=10)
Note: compare with blank group, 1. null hypothesis value P < 0.05,2. null hypothesis value P < 0.01.
Result shows, containing Herba Cancriniae lasiocarpae extract toothpaste, significantly reduces the mouse writhing number of times of glacial acetic acid induced pain, incubation period
Extend inconspicuous.
Three, the toothpaste antiinflammatory experiment containing Herba Cancriniae lasiocarpae extract
Experimental technique is mice auricle swelling method.The ear edema coefficient of medication group and blank group carry out adding up credit
Analysis, does t inspection between two groups, the results are shown in Table 2.
Statistical result (the x of the impact of table 2 test sample (containing Herba Cancriniae lasiocarpae extract) xylol induced mice auricle edema
±S,n=11)
Note: compare with blank group, 1. null hypothesis value P < 0.05,2. null hypothesis value P < 0.01.
Result shows, the extract toothpaste xylol induced mice auricle edema containing Herba Cancriniae lasiocarpae has obvious inhibitory action,
Notable with blank group comparing difference.
Four, containing the exciting salivary secretion clinical experiment of Herba Cancriniae lasiocarpae extract toothpaste
Choosing experimenter 60 people to test, men and women half and half, has xerostomia or diabetics 30 people, and the age is from 18-
58 years old, 30 years old mean age.Carrying out double-blind comparison's test, random toothpaste on probation is brushed teeth and detects salivation.Experiment toothpaste contains
There is golden button extract, use case 2 toothpaste；Blank toothpaste does not contains above-mentioned active substance.Test first 1 hour, do not take food,
Do not brush teeth or gargle, not smoking and drink.
During test, first test need not be tested toothpaste and brush teeth prosopyle chamber salivation amount；After using test toothpaste to brush teeth, respectively
Test the 1st minute, the 2nd minute, the salivation amount of the 3rd minute after brushing teeth, thus judge the ability of toothpaste exciting salivary secretion.
After using toothpaste to brush teeth, saliva amount situation of change see table.Before from table, we are it is found that use toothpaste, saliva
Liquid measure compares less.After brushing teeth with toothpaste, all can increase saliva amount secretion, and within the 1st minute, reach maximum after the brushing.
But using experimental group toothpaste to brush teeth, saliva stimulating increase becomes apparent from, and two groups of data carry out paired sample T test, and its average has
There is significant difference (P=0.037 < 0.05).
Saliva amount change table: (unit: ml)
Clinical experiment shows, uses the toothpaste containing gold button extract, can be obviously promoted salivation after brushing teeth.
Claims (5)
1. application of spilantes acmella extract in preparation of mouth care materials, i.e. by gold in the technique prepare oral care implement
Button extract as promoting the production of body fluid, antiinflammatory and analgesic sole active agent add in oral care implement, described Herba Cancriniae lasiocarpae extracts
The preparation technology of thing comprises the following steps:
Step 1, take Chinese medicine Herba Cancriniae lasiocarpae medical material, be cut into 1～2cm segment；
Step 2, at 30 DEG C～90 DEG C, with 3～5 times 30%～99% ethanol, backflow carries 2～8h, reflux, extract, 3～5 times；
Step 3, filtrate are under the conditions of low temperature≤50 DEG C, and decompression recycling ethanol obtains Herba Cancriniae lasiocarpae extract.
Application of spilantes acmella extract in preparation of mouth care materials the most according to claim 1, is characterized in that: described
Herba Cancriniae lasiocarpae extract in preparing toothpaste technique as promoting the production of body fluid, antiinflammatory and the raw material of analgesic activity.
Application of spilantes acmella extract in preparation of mouth care materials the most according to claim 2, is characterized in that: described
Herba Cancriniae lasiocarpae extract percentage by weight in total mastic of toothpaste is 0.1%～5%.
Application of spilantes acmella extract in preparation of mouth care materials the most according to claim 1, is characterized in that: described
Herba Cancriniae lasiocarpae extract in preparing collutory technique as promoting the production of body fluid, antiinflammatory and the raw material of analgesic activity.
Application of spilantes acmella extract in preparation of mouth care materials the most according to claim 4, is characterized in that: described
Herba Cancriniae lasiocarpae extract percentage by weight in collutory raw material is 0.1%～5%.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104435234A (en) * | 2014-12-05 | 2015-03-25 | 董梅 | Pharmaceutical composition for treating gynecological xerostomia |
| CN106038417B (en) * | 2016-07-19 | 2019-01-29 | 深圳波顿香料有限公司 | Golden button flower extract and preparation method thereof and its application in skin care item |
| CN108815001B (en) * | 2018-07-02 | 2021-11-30 | 博凯药业有限公司 | Mouthwash effervescent tablet and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102113986A (en) * | 2011-03-01 | 2011-07-06 | 柳州两面针股份有限公司 | Toothpaste suitable for diabetes patients |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102113986A (en) * | 2011-03-01 | 2011-07-06 | 柳州两面针股份有限公司 | Toothpaste suitable for diabetes patients |
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