CN105876786A - Semen hoveniae chewable tablets capable of of freshening breath and alleviating alcohol effect and preparation method thereof - Google Patents
Semen hoveniae chewable tablets capable of of freshening breath and alleviating alcohol effect and preparation method thereof Download PDFInfo
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- CN105876786A CN105876786A CN201610238322.9A CN201610238322A CN105876786A CN 105876786 A CN105876786 A CN 105876786A CN 201610238322 A CN201610238322 A CN 201610238322A CN 105876786 A CN105876786 A CN 105876786A
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 60
- 230000000694 effects Effects 0.000 title claims abstract description 45
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 210000000582 semen Anatomy 0.000 title abstract 6
- 239000000843 powder Substances 0.000 claims abstract description 98
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 63
- 239000008187 granular material Substances 0.000 claims abstract description 30
- 238000001035 drying Methods 0.000 claims abstract description 23
- 108010011485 Aspartame Proteins 0.000 claims abstract description 21
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 21
- 229930195725 Mannitol Natural products 0.000 claims abstract description 21
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims abstract description 21
- 235000010357 aspartame Nutrition 0.000 claims abstract description 21
- 239000000605 aspartame Substances 0.000 claims abstract description 21
- 229960003438 aspartame Drugs 0.000 claims abstract description 21
- 235000010355 mannitol Nutrition 0.000 claims abstract description 21
- 239000000594 mannitol Substances 0.000 claims abstract description 21
- 239000007779 soft material Substances 0.000 claims abstract description 20
- 244000269722 Thea sinensis Species 0.000 claims abstract description 15
- 235000009569 green tea Nutrition 0.000 claims abstract description 15
- 238000005469 granulation Methods 0.000 claims abstract description 7
- 230000003179 granulation Effects 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 230000001954 sterilising effect Effects 0.000 claims abstract description 7
- 244000010000 Hovenia dulcis Species 0.000 claims description 45
- 235000008584 Hovenia dulcis Nutrition 0.000 claims description 45
- 235000013399 edible fruits Nutrition 0.000 claims description 45
- 244000202052 Poncirus trifoliata Species 0.000 claims description 34
- 235000000404 Poncirus trifoliata Nutrition 0.000 claims description 34
- 229940068682 chewable tablet Drugs 0.000 claims description 33
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 12
- 238000000605 extraction Methods 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 229940046011 buccal tablet Drugs 0.000 claims description 7
- 239000006189 buccal tablet Substances 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 6
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 6
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 230000001678 irradiating effect Effects 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 6
- 235000019359 magnesium stearate Nutrition 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 239000003826 tablet Substances 0.000 claims description 5
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 230000035622 drinking Effects 0.000 abstract description 21
- 239000000126 substance Substances 0.000 abstract description 9
- 206010067125 Liver injury Diseases 0.000 abstract description 6
- 230000006870 function Effects 0.000 abstract description 6
- 231100000753 hepatic injury Toxicity 0.000 abstract description 6
- 210000004185 liver Anatomy 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 2
- 244000246386 Mentha pulegium Species 0.000 abstract 1
- 235000016257 Mentha pulegium Nutrition 0.000 abstract 1
- 235000004357 Mentha x piperita Nutrition 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 235000012907 honey Nutrition 0.000 abstract 1
- 235000001050 hortel pimenta Nutrition 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 11
- 210000002784 stomach Anatomy 0.000 description 7
- 230000036541 health Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 208000005584 Alcoholic Intoxication Diseases 0.000 description 2
- 206010016322 Feeling abnormal Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000002443 hepatoprotective effect Effects 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- AEUTYOVWOVBAKS-UWVGGRQHSA-N ethambutol Natural products CC[C@@H](CO)NCCN[C@@H](CC)CO AEUTYOVWOVBAKS-UWVGGRQHSA-N 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
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- 235000012054 meals Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
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- 231100000957 no side effect Toxicity 0.000 description 1
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- 230000001737 promoting effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention relates to the field of hoveniae comprehensive application, and particularly relates to semen hoveniae chewable tablets capable of freshening breath and alleviating alcohol effects and a preparation method thereof. The chewable tablets are prepared from the following raw materials in parts by weight: 30-45 parts of semen hoveniae, 15-25 parts of kudzu vine roots, 5-10 parts of haws, 3-6 parts of peppermint or green tea powder, 10-14 parts of honey, 3-4 parts of aspartame, 2-5 parts of citric acid and 1-2 parts of mannitol. The preparation method of the chewable tablets comprises the following steps of 1, preparing semen hoveniae extract powder, 2, conducting blending; 3, preparing a soft material; 4, conducting granulation; 5, conducting drying; 6, conducting granule separation; 7, conducting tabletting; and 8, conducting sterilization and package. The semen hoveniae chewable tablets have functions of alleviating alcohol effects, protecting and preventing chemical liver injury, and is used for protecting the liver before and after alcohol drinking, restoring normal functions of a body after drunkenness, and protecting chemical liver injury caused by external chemical factors, and the semen hoveniae chewable tablets have wide application values, and have the advantages of breath freshening, good flavor and no toxic or side effects, and is quick in response and convenient to carry and transport.
Description
Technical field
The present invention relates to the integrated application field of trifoliate orange, be specifically related to a kind of can fresh breath and the trifoliate orange chewable tablet that relieves the effect of alcohol and preparation method thereof.
Background technology
Relieve the effect of alcohol, protect and prevent the function of chemical liver injury, the liver protecting before being used for drinking, after drinking hepatoprotective owing to drunk-sobering tablet has, recover drunk after health normal function, protect the chemical liver injury caused due to extraneous chemical factor, be with a wide range of applications.But, owing to the existing preparation technology of drunk-sobering tablet falls behind, use crude drug tabletting, it is slow that dosage form absorbs onset, bioavailability is low, can not quickly reach relieving alcoholism and protecting the liver, the effect of recovery physical function, be not suitable for present society and drink and the needs of the crowd that keeps healthy, therefore the scope of application have received restriction greatly.
Trifoliate orange itself has high medical value, its son can clearing away heat and promoting diuresis, cough-relieving relieving restlessness, alcoholic intoxication；Its micromicro is invigorated blood circulation, and relaxing muscles and tendons detoxifies, and for sural spasm, food stagnation, Radix aconiti szechenyiani is poisoned；Its carpopodium can stomach invigorating, enrich blood.Preparation method (notification number: the CN103610060B of a kind of VC trifoliate orange alcohol disintoxication chewable tablet as disclosed in Chinese patent literature, on February 25th, 2015 authorizes), specifically include supplementary material sieve, weigh supplementary material, mix, soft material processed, pelletize, dry, granulate, total mixed, tabletting totally nine steps, thus solve the absorption difference that existing drunk-sobering tablet exists with crude drug tabletting, oral administration biaavailability is low, the problem that onset is slow.But, the technical scheme in this patent of invention, final tabletting is not carried out disinfecting action, easily cause the generation of the defective phenomenon of health examination.
Summary of the invention
The underproof problem of the health examination that it is an object of the invention to overcome existing Sobering-up buccal tablet tabletting not to be carried out disinfecting action present in the preparation process and to cause.
To this end, the invention provides a kind of can fresh breath and the trifoliate orange chewable tablet that relieves the effect of alcohol and preparation method thereof, including:
A kind of can fresh breath and the trifoliate orange chewable tablet that relieves the effect of alcohol, being made up of following raw material: Japanese raisintree fruit, Radix Puerariae, Fructus Crataegi, Herba Menthae or green tea powder, Mel, aspartame, citric acid, mannitol, the weight of described raw material is Japanese raisintree fruit 30-45 part, Radix Puerariae 15-25 part, Fructus Crataegi 5-10 part, Herba Menthae or green tea powder 3-6 part, Mel 10-14 part, aspartame 3-4 part, citric acid 2-5 part, mannitol 1-2 part.
A kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, specifically include following steps:
Step one, preparing Japanese raisintree fruit extract powder: pulverized by Japanese raisintree fruit, add the flooding of 7 times amount, regulation pH value is 8, extraction temperature 75 DEG C, extraction time 90min, extract 3 times, every time lixiviating solution is by 60 mesh filter screen coarse filtration, merging 3 filtrates, upper filter fine straining, filtrate is inserted vacuum concentration pan and is condensed into thick extractum, thick extractum is entered drying baker and is dried to moisture less than 3%, put into multifunctional mixer and be broken into powder, cross 100 mesh sieves, obtain Japanese raisintree fruit extract powder；
Step 2, allotment: adding Fructus Crataegi powder, green tea powder or Herba Menthae powder, Mel, powder of Radix Puerariae, mannitol powder, aspartame in step one gained Japanese raisintree fruit extract powder, xylose and citric acid are allocated；
Step 3, make soft material: by the Japanese raisintree fruit extract powder in step one with and step 2 in dispensing powder carry out proportioning by following weight portion: Japanese raisintree fruit extract powder 30-45 part, powder of Radix Puerariae 15-25 part, Fructus Crataegi powder 5-10 part, green tea powder or Herba Menthae powder 3-6 part, Mel 10-14 part, aspartame 3-4 part, citric acid 2-5 part, mannitol 1-2 part, after mix homogeneously, it is slowly added into wet adhesive 70% ethanol, constantly stir simultaneously, make neither too hard, nor too soft soft material；
Step 4, granulation: sieving as the instrument pelletized using 18 mesh, hold soft for step 3 gained material
Agglomerating, press through 18 mesh sieves, make soft material become graininess；
Step 5, be dried: step 4 gained granule is placed in drying baker be dried, stir 1 time every 0.5h, to accelerate rate of drying；
Step 6, granulate: the granule being dried by step 5 gained, cross 1 16 mesh sieve；
Step 7, tabletting: add 3% magnesium stearate in step 6 gained granulate and make lubricant, add a cover standing, with abnormity tabletting machine；
Step 8, sterilizing and packaging: step 7 gained buccal tablet is put after irradiating under ultraviolet light, pack in time.
Above-mentioned a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, the vacuum concentration pan described in described step one, vacuum during work is 97kPa, and temperature is 55 DEG C ± 5 DEG C.
Above-mentioned a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, the granule described in described step 5 is dried at a temperature of 60 DEG C.
Above-mentioned a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, the drying time that the granule described in described step 5 is placed in drying baker is 3h.
Above-mentioned a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, the different in nature tablet machine described in described step 7 uses triangle punch die tabletting.
Above-mentioned a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, the time of repose described in described step 7 is 10min-15min.
Above-mentioned a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, under the ultraviolet described in described step 8, irradiation time is 20min-30min.
Beneficial effects of the present invention: the present invention provide this can fresh breath and the trifoliate orange chewable tablet that relieves the effect of alcohol; there is the function relieving the effect of alcohol, protect and preventing chemical liver injury; the liver protecting before drinking; hepatoprotective after drinking; recover drunk after health normal function; protect the chemical liver injury caused due to extraneous chemical factor, be with a wide range of applications.Having fresh breath concurrently, taste is good simultaneously, and the advantage of no side effects, and instant effect are convenient for carrying and transport.
Below with reference to embodiment, the present invention is described in further details.
Detailed description of the invention
Reach, by the present invention is expanded on further, Chinese medicinal components and effect that predetermined purpose is taked, describe in detail as follows by following brief introduction and embodiment.
Embodiment 1:
A kind of can fresh breath and the trifoliate orange chewable tablet that relieves the effect of alcohol, be made up of the raw material of following weight portion: Japanese raisintree fruit 40 parts, Radix Puerariae 25 parts, Fructus Crataegi 10 parts, Herba Menthae powder 5 parts, Mel 12 parts, aspartame 4 parts, citric acid 2 parts, 2 parts of mannitol.
A kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, specifically include following steps:
Step one, prepare Japanese raisintree fruit extract powder: pulverized by Japanese raisintree fruit, adding the flooding of 7 times amount, regulation pH value is 8, extraction temperature 75 DEG C, extraction time 90min, extracting 3 times, each lixiviating solution, by 60 mesh filter screen coarse filtration, merges 3 filtrates, go up filter fine straining again, filtrate is inserted vacuum concentration pan and is condensed into thick extractum, and wherein, the vacuum of vacuum concentration pan is 97
KPa, temperature is 55 DEG C；Again thick extractum is entered drying baker and be dried to moisture less than 3%, put into multifunctional mixer and be broken into powder, cross 100 mesh sieves, obtain Japanese raisintree fruit extract powder；
Step 2, allotment: adding Fructus Crataegi powder, Herba Menthae powder, Mel, powder of Radix Puerariae in step one gained Japanese raisintree fruit extract powder, mannitol powder, aspartame, xylose and citric acid are allocated；
Step 3, make soft material: by the Japanese raisintree fruit extract powder in step one with and step 2 in dispensing powder carry out proportioning by following weight portion: Japanese raisintree fruit extract powder 40 parts, powder of Radix Puerariae 25 parts, Fructus Crataegi powder 10 parts, Herba Menthae powder 5 parts, Mel 12 parts, aspartame 4 parts, citric acid 2 parts, 2 parts of mannitol, after mix homogeneously, it is slowly added into wet adhesive 70% ethanol, constantly stir simultaneously, make neither too hard, nor too soft soft material；
Step 4, granulation: sieving as the instrument pelletized using 18 mesh, hold soft for step 3 gained material agglomerating, pressure
Cross 18 mesh sieves, make soft material become graininess；
Step 5, be dried: step 4 gained granule is placed in the drying baker of 60 DEG C be dried 3h, stir 1 time every 0.5h, to accelerate rate of drying；
Step 6, granulate: the granule being dried by step 5 gained, cross 1 16 mesh sieve；
Step 7, tabletting: add 3% magnesium stearate in step 6 gained granulate and make lubricant, add a cover standing 10min, with triangle punch die tabletting；
Step 8, sterilizing and packaging: step 7 gained buccal tablet is put after irradiating 20min under ultraviolet light, pack in time.
Embodiment 2:
As different from Example 1: a kind of can fresh breath and the weight portion of trifoliate orange chewable tablet constitutive material that relieves the effect of alcohol as follows: Japanese raisintree fruit 39 parts, Radix Puerariae 24 parts, Fructus Crataegi 10 parts, Herba Menthae powder 5 parts, Mel 10 parts, aspartame 4 parts, citric acid 6 parts, 2 parts of mannitol.
A kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, specifically include following steps:
Step one, prepare Japanese raisintree fruit extract powder: pulverized by Japanese raisintree fruit, adding the flooding of 7 times amount, regulation pH value is 8, extraction temperature 75 DEG C, extraction time 90min, extracting 3 times, each lixiviating solution, by 60 mesh filter screen coarse filtration, merges 3 filtrates, go up filter fine straining again, filtrate is inserted vacuum concentration pan and is condensed into thick extractum, and wherein, the vacuum of vacuum concentration pan is 97
KPa, temperature is 60 DEG C；Again thick extractum is entered drying baker and be dried to moisture less than 3%, put into multifunctional mixer and be broken into powder, cross 100 mesh sieves, obtain Japanese raisintree fruit extract powder；
Step 2, allotment: adding Fructus Crataegi powder, Herba Menthae powder, Mel, powder of Radix Puerariae in step one gained Japanese raisintree fruit extract powder, mannitol powder, aspartame, xylose and citric acid are allocated；
Step 3, make soft material: by the Japanese raisintree fruit extract powder in step one with and step 2 in dispensing powder carry out proportioning by following weight portion: Japanese raisintree fruit extract powder 39 parts, powder of Radix Puerariae 24 parts, Fructus Crataegi powder 10 parts, Herba Menthae powder 5 parts, Mel 10 parts, aspartame 4 parts, citric acid 6 parts, 2 parts of mannitol, after mix homogeneously, it is slowly added into wet adhesive 70% ethanol, constantly stir simultaneously, make neither too hard, nor too soft soft material；
Step 4, granulation: sieving as the instrument pelletized using 18 mesh, hold soft for step 3 gained material agglomerating, pressure
Cross 18 mesh sieves, make soft material become graininess；
Step 5, be dried: step 4 gained granule is placed in the drying baker of 60 DEG C be dried 3h, stir 1 time every 0.5h, to accelerate rate of drying；
Step 6, granulate: the granule being dried by step 5 gained, cross 1 16 mesh sieve；
Step 7, tabletting: add 3% magnesium stearate in step 6 gained granulate and make lubricant, add a cover standing 15min, with triangle punch die tabletting；
Step 8, sterilizing and packaging: step 7 gained buccal tablet is put after irradiating 25min under ultraviolet light, pack in time.
Embodiment 3:
Unlike embodiment 1 or 2: a kind of can fresh breath and the weight portion of trifoliate orange chewable tablet constitutive material that relieves the effect of alcohol as follows: Japanese raisintree fruit 39 parts, Radix Puerariae 24 parts, Fructus Crataegi 10 parts, green tea powder 5 parts, Mel 10 parts, aspartame 4 parts, citric acid 6 parts, 2 parts of mannitol.
A kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, specifically include following steps:
Step one, prepare Japanese raisintree fruit extract powder: pulverized by Japanese raisintree fruit, adding the flooding of 7 times amount, regulation pH value is 8, extraction temperature 75 DEG C, extraction time 90min, extracting 3 times, each lixiviating solution, by 60 mesh filter screen coarse filtration, merges 3 filtrates, go up filter fine straining again, filtrate is inserted vacuum concentration pan and is condensed into thick extractum, and wherein, the vacuum of vacuum concentration pan is 97
KPa, temperature is 50 DEG C；Again thick extractum is entered drying baker and be dried to moisture less than 3%, put into multifunctional mixer and be broken into powder, cross 100 mesh sieves, obtain Japanese raisintree fruit extract powder；
Step 2, allotment: adding Fructus Crataegi powder, green tea powder, Mel, powder of Radix Puerariae in step one gained Japanese raisintree fruit extract powder, mannitol powder, aspartame, xylose and citric acid are allocated；
Step 3, make soft material: by the Japanese raisintree fruit extract powder in step one with and step 2 in dispensing powder carry out proportioning by following weight portion: Japanese raisintree fruit extract powder 39 parts, powder of Radix Puerariae 24 parts, Fructus Crataegi powder 10 parts, green tea powder 5 parts, Mel 10 parts, aspartame 4 parts, citric acid 6 parts, 2 parts of mannitol, after mix homogeneously, it is slowly added into wet adhesive 70% ethanol, constantly stir simultaneously, make neither too hard, nor too soft soft material；
Step 4, granulation: sieving as the instrument pelletized using 18 mesh, hold soft for step 3 gained material agglomerating, pressure
Cross 18 mesh sieves, make soft material become graininess；
Step 5, be dried: step 4 gained granule is placed in the drying baker of 60 DEG C be dried 3h, stir 1 time every 0.5h, to accelerate rate of drying；
Step 6, granulate: the granule being dried by step 5 gained, cross 1 16 mesh sieve；
Step 7, tabletting: add 3% magnesium stearate in step 6 gained granulate and make lubricant, add a cover standing 12min, with abnormity tabletting machine；
Step 8, sterilizing and packaging: step 7 gained buccal tablet is put after irradiating 22min under ultraviolet light, pack in time.
Embodiment 4:
Unlike one of embodiment 1 to 3: a kind of can fresh breath and the weight portion of trifoliate orange chewable tablet constitutive material that relieves the effect of alcohol as follows: Japanese raisintree fruit 40 parts, Radix Puerariae 25 parts, Fructus Crataegi 10 parts, green tea powder 5 parts, Mel 12 parts, aspartame 4 parts, citric acid 2 parts, 2 parts of mannitol.
A kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, specifically include following steps:
Step one, prepare Japanese raisintree fruit extract powder: pulverized by Japanese raisintree fruit, adding the flooding of 7 times amount, regulation pH value is 8, extraction temperature 75 DEG C, extraction time 90min, extracting 3 times, each lixiviating solution, by 60 mesh filter screen coarse filtration, merges 3 filtrates, go up filter fine straining again, filtrate is inserted vacuum concentration pan and is condensed into thick extractum, and wherein, the vacuum of vacuum concentration pan is 97
KPa, temperature is 52 DEG C；Again thick extractum is entered drying baker and be dried to moisture less than 3%, put into multifunctional mixer and be broken into powder, cross 100 mesh sieves, obtain Japanese raisintree fruit extract powder；
Step 2, allotment: adding Fructus Crataegi powder, green tea powder, Mel, powder of Radix Puerariae in step one gained Japanese raisintree fruit extract powder, mannitol powder, aspartame, xylose and citric acid are allocated；
Step 3, make soft material: by the Japanese raisintree fruit extract powder in step one with and step 2 in dispensing powder carry out proportioning by following weight portion: Japanese raisintree fruit extract powder 40 parts, powder of Radix Puerariae 25 parts, Fructus Crataegi powder 10 parts, green tea powder 5 parts, Mel 12 parts, aspartame 4 parts, citric acid 2 parts, 2 parts of mannitol, after mix homogeneously, it is slowly added into wet adhesive 70% ethanol, constantly stir simultaneously, make neither too hard, nor too soft soft material；
Step 4, granulation: sieving as the instrument pelletized using 18 mesh, hold soft for step 3 gained material agglomerating, pressure
Cross 18 mesh sieves, make soft material become graininess；
Step 5, be dried: step 4 gained granule is placed in the drying baker of 60 DEG C be dried 3h, stir 1 time every 0.5h, to accelerate rate of drying；
Step 6, granulate: the granule being dried by step 5 gained, cross 1 16 mesh sieve；
Step 7, tabletting: add 3% magnesium stearate in step 6 gained granulate and make lubricant, add a cover standing 14min, with triangle punch die tabletting；
Step 8, sterilizing and packaging: step 7 gained buccal tablet is put after irradiating 28min under ultraviolet light, pack in time.
The application present invention this can fresh breath and the trifoliate orange chewable tablet that relieves the effect of alcohol before wine, in wine, carried out crowd's test the most respectively, test shows: take the present invention before wine, but flushing, dizziness, the stomach that occur after drinking at ordinary times the uncomfortable symptom such as are felt bad and alleviated and even do not occur；And wine neutralizes and takes after drinking, the various uncomfortable symptom occurred after can making to drink rapidly be alleviation.
Experimental study of the present invention statistics shows, 100 alcohol users that grow up voluntarily take before drinking, and capacity for liquor increases by 1/3～1/2 than original；Wherein 89 famous-drinks occur that the men and women of the symptoms such as dizziness, uncomfortable in chest, stomach is felt bad takes after drinking, and above-mentioned symptom is quickly eased, and responding time is 3～4 minutes；The men and women that wherein 80 famous-drinks various uncomfortable symptoms occur in second day after drinking takes, and above-mentioned uncomfortable symptom does not occur for second day.
The part typical case of the present invention is as follows:
1, Lee, man, 35 years old, it is only capable of drinking about three liang of wine, takes that the present invention is this can drink half jin of wine and do not feel to feel bad after fresh breath and the trifoliate orange chewable tablet that relieves the effect of alcohol；
2, Zhang, man, 30 years old, arising that flushing, stomach such as feels bad at the uncomfortable symptom as long as drinking at ordinary times, taking that the present invention is this can not feel bad, and capacity for liquor has significantly increase after fresh breath and the trifoliate orange chewable tablet that relieves the effect of alcohol；
3, Liu, man, 40 years old, three liang of wine were the most liquor-saturated at ordinary times, after taking the present invention every time, can drink that four, five liang of wine is the most liquor-saturated and nothing feels bad sensation before drinking；
4, Song, man, 29 years old, seldom drink, and feel after drinking to feel bad, sleepy is felt, evening March 13 in 2016, there is not uncomfortable symptom in the present invention bfore meals 2 after drinking 3 two 50 ° of Chinese liquor, and second day does not has sense of discomfort yet；
5, time, man, 50 years old, three liang of wine were the most liquor-saturated at ordinary times, and talked about the most, stomach after drinking and feel bad, and after taking the present invention 2, uncomfortable symptom do not occur, and second day does not has sense of discomfort yet after drinking half jin of 50 ° of Chinese liquor；
6, Hu, man, 32 years old, treat with courtesy the most at ordinary times, stomach is felt bad, is vomitted after drinking, after on February 14th, 2016 takes the present invention after drinking, above-mentioned uncomfortable symptom does not occurs, and second day does not has sense of discomfort yet；
7, Lee, man, 45 years old, the most often drink, after drinking stomach feel bad, vomit, serious when also with carelessly falling the phenomenon of thing, after taking the present invention before drinking on March 5th, 2016, above-mentioned uncomfortable symptom and clumsy phenomenon do not occur, and second day does not has sense of discomfort.
To sum up, owing to raw material of the present invention is theoretical according to traditional Chinese medical science integration of edible and medicinal herbs, it is other compositions of main combination with Japanese raisintree fruit and Radix Puerariae, as a kind of alcohol disintoxication chewable tablet, do not have any side effect, solve the existing product that relieve the effect of alcohol and have the drawback of side effect, and dispelling effects of alcohol is good, it uses medicine-food two-purpose composition, it is possible not only to improve the metabolism that ethanol causes, effectively decompose ethanol, alleviate the infringement of the liver cell to human body, and can effectively delay alcohol absorption, Mel owing to containing is relieving alcoholic intoxication again, clearing away stomach-heat, orectic " good medicine ", increase dispelling effects of alcohol, preparation section of the present invention is simple and quick, the production cost making the present invention is low, meet the emergent demand of client.
Above content is to combine concrete preferred implementation further description made for the present invention, it is impossible to assert the present invention be embodied as be confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, it is also possible to make some simple deduction or replace, all should be considered as belonging to protection scope of the present invention.
Claims (8)
1. one kind can fresh breath and the trifoliate orange chewable tablet that relieves the effect of alcohol, it is characterized in that: be made up of following raw material: Japanese raisintree fruit, Radix Puerariae, Fructus Crataegi, Herba Menthae or green tea powder, Mel, aspartame, citric acid, mannitol, the weight of described raw material is Japanese raisintree fruit 30-45 part, Radix Puerariae 15-25 part, Fructus Crataegi 5-10 part, Herba Menthae or green tea powder 3-6 part, Mel 10-14 part, aspartame 3-4 part, citric acid 2-5 part, mannitol 1-2 part.
2. can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, specifically include following steps:
Step one, preparing Japanese raisintree fruit extract powder: pulverized by Japanese raisintree fruit, add the flooding of 7 times amount, regulation pH value is 8, extraction temperature 75 DEG C, extraction time 90min, extract 3 times, every time lixiviating solution is by 60 mesh filter screen coarse filtration, merging 3 filtrates, upper filter fine straining, filtrate is inserted vacuum concentration pan and is condensed into thick extractum, thick extractum is entered drying baker and is dried to moisture less than 3%, put into multifunctional mixer and be broken into powder, cross 100 mesh sieves, obtain Japanese raisintree fruit extract powder；
Step 2, allotment: adding Fructus Crataegi powder, green tea powder or Herba Menthae powder, Mel, powder of Radix Puerariae, mannitol powder, aspartame in step one gained Japanese raisintree fruit extract powder, xylose and citric acid are allocated；
Step 3, make soft material: by the Japanese raisintree fruit extract powder in step one with and step 2 in dispensing powder carry out proportioning by following weight portion: Japanese raisintree fruit extract powder 30-45 part, powder of Radix Puerariae 15-25 part, Fructus Crataegi powder 5-10 part, green tea powder or Herba Menthae powder 3-6 part, Mel 10-14 part, aspartame 3-4 part, citric acid 2-5 part, mannitol 1-2 part, after mix homogeneously, it is slowly added into wet adhesive 70% ethanol, constantly stir simultaneously, make neither too hard, nor too soft soft material；
Step 4, granulation: sieving as the instrument pelletized using 18 mesh, hold soft for step 3 gained material
Agglomerating, press through 18 mesh sieves, make soft material become graininess；
Step 5, be dried: step 4 gained granule is placed in drying baker be dried, stir 1 time every 0.5h, to accelerate rate of drying；
Step 6, granulate: the granule being dried by step 5 gained, cross 1 16 mesh sieve；
Step 7, tabletting: add 3% magnesium stearate in step 6 gained granulate and make lubricant, add a cover standing, with abnormity tabletting machine；
Step 8, sterilizing and packaging: step 7 gained buccal tablet is put after irradiating under ultraviolet light, pack in time.
The most according to claim 2 a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, it is characterised in that: the vacuum concentration pan described in described step one, vacuum during work is 97kPa, and temperature is 55 DEG C ± 5 DEG C.
The most according to claim 2 a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, it is characterised in that: the granule described in described step 5 is dried at a temperature of 60 DEG C.
The most according to claim 2 a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, it is characterised in that: the drying time that the granule described in described step 5 is placed in drying baker is 3h.
The most according to claim 2 a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, it is characterised in that: the different in nature tablet machine described in described step 7 uses triangle punch die tabletting.
The most according to claim 2 a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, it is characterised in that: the time of repose described in described step 7 is 10min-15min.
The most according to claim 2 a kind of can fresh breath and the preparation method of trifoliate orange chewable tablet relieved the effect of alcohol, it is characterised in that: under the ultraviolet described in described step 8, irradiation time is 20min-30min.
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Cited By (7)
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| CN106962538A (en) * | 2017-04-19 | 2017-07-21 | 湖南古洞春茶业有限公司 | A kind of green tea chewable tablets and preparation method thereof |
| CN107125652A (en) * | 2017-05-09 | 2017-09-05 | 河南科技大学 | A kind of pure and fresh, strong tooth, the soft preparation method for chewing piece of health-care type green tea |
| CN108308611A (en) * | 2017-12-29 | 2018-07-24 | 河南健特生物科技集团有限公司 | A kind of chewable tablets and preparation method thereof for capableing of fresh breath |
| CN108815361A (en) * | 2018-07-16 | 2018-11-16 | 陈帅 | A kind of Chinese medicinal drink orchid chrysanthemum perfume (or spice) mouth tea that can make one breath freshening |
| CN108936450A (en) * | 2018-08-28 | 2018-12-07 | 贵州宏财聚农投资有限责任公司 | A kind of Rosa roxburghii Tratt lozenge and preparation method thereof |
| CN109045273A (en) * | 2018-11-09 | 2018-12-21 | 何蓉蓉 | A kind of Chinese medicinal alcoholism-relieving composition and preparation method thereof |
| CN111135228A (en) * | 2020-01-15 | 2020-05-12 | 宁夏医科大学 | Chewable tablet for protecting liver and preparation method thereof |
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| CN103082362A (en) * | 2013-01-24 | 2013-05-08 | 黄冰 | Traditional Chinese medicine drink |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106962538A (en) * | 2017-04-19 | 2017-07-21 | 湖南古洞春茶业有限公司 | A kind of green tea chewable tablets and preparation method thereof |
| CN107125652A (en) * | 2017-05-09 | 2017-09-05 | 河南科技大学 | A kind of pure and fresh, strong tooth, the soft preparation method for chewing piece of health-care type green tea |
| CN108308611A (en) * | 2017-12-29 | 2018-07-24 | 河南健特生物科技集团有限公司 | A kind of chewable tablets and preparation method thereof for capableing of fresh breath |
| CN108815361A (en) * | 2018-07-16 | 2018-11-16 | 陈帅 | A kind of Chinese medicinal drink orchid chrysanthemum perfume (or spice) mouth tea that can make one breath freshening |
| CN108936450A (en) * | 2018-08-28 | 2018-12-07 | 贵州宏财聚农投资有限责任公司 | A kind of Rosa roxburghii Tratt lozenge and preparation method thereof |
| CN109045273A (en) * | 2018-11-09 | 2018-12-21 | 何蓉蓉 | A kind of Chinese medicinal alcoholism-relieving composition and preparation method thereof |
| CN111135228A (en) * | 2020-01-15 | 2020-05-12 | 宁夏医科大学 | Chewable tablet for protecting liver and preparation method thereof |
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