CN107362223A - A kind of Chinese medicine composition containing Cornu Cervi cowl glue and preparation method and application - Google Patents
A kind of Chinese medicine composition containing Cornu Cervi cowl glue and preparation method and application Download PDFInfo
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- CN107362223A CN107362223A CN201710812762.5A CN201710812762A CN107362223A CN 107362223 A CN107362223 A CN 107362223A CN 201710812762 A CN201710812762 A CN 201710812762A CN 107362223 A CN107362223 A CN 107362223A
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- cornu cervi
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- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Developmental Biology & Embryology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to tcm field, in particular to a kind of Chinese medicine composition containing Cornu Cervi cowl glue and preparation method and application.The Chinese medicine composition is mainly made up of the raw material of following proportioning：The parts by weight of honeysuckle 6~14, the parts by weight of dried orange peel 6~14, the parts by weight of Buddha's hand 5~9, the parts by weight of peach kernel 1~4 and the parts by weight of Cornu Cervi cowl glue 8~17.The Chinese medicine composition can effectively treat various inflammatory reactions, especially glandular inflammation.
Description
Technical field
The present invention relates to tcm field, in particular to a kind of Chinese medicine composition and its system containing Cornu Cervi cowl glue
Preparation Method and application.
Background technology
Cornu Cervi cowl is animal in deer family sika deer (Cervus nippon Temminck) or red deer (Cervus elaphus
Linnaeus the angle base that spring in next year comes off after) saw is fine and soft, it is disc-shaped, " ossificational antler ", " deer horn disk stripping ", " Cornu Cervi " are also known as, with
The thing of Xylaria one.Before more than 2000 years《Sheng Nong's herbal classic》, top grade is classified as, there is warming and invigorating kidney Yang, activating blood circulation and reducing swelling, Zhi Yin
Disease sore, acute mastitis are from the beginning of, strengthening the bones and muscles, the promoting circulation of blood detumescence the effect of.Cornu Cervi cowl moves back angle and cuts two kinds of angle.It is how naturally de- in spring to move back angle
Fall, be preferred with the angle that late spring pickup newly comes off；It is general in the winter time or angle is connected brain bone and cut down by early spring to saw angle, or under base portion saw,
Air-dry.Modern study shows that Cornu Cervi cowl has antitumor, the treatment proliferation of mammary gland, enhancing is immune, anti-oxidant, antifatigue, suppresses bone
Matter is loose, promotes a variety of pharmacological activity such as skeletal injury reparation.
Containing abundant protein, amino acid and a small amount of lipid in Cornu Cervi cowl, and containing substantial amounts of calcium, phosphorus and zinc, iron, manganese,
The trace elements such as strontium, wherein abundant protein is the main effective component of Cornu Cervi cowl.Rich in abundant deer horn in Cornu Cervi cowl glue
Cap protein, and there are antiphlogistic effects through research, but existing single Cornu Cervi cowl glue anti-inflammatory effect is also not satisfactory, needs
In further research and development.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of Chinese medicine composition containing Cornu Cervi cowl glue, described Chinese medicine composition
With good drug efficacy, the advantages that without obvious toxicity.
The Chinese medicine composition of the present invention is mainly made up of the raw material of following proportioning：
The parts by weight of honeysuckle 6~14, the parts by weight of dried orange peel 6~14, the parts by weight of Buddha's hand 5~9, the parts by weight of peach kernel 1~4 and deer
The parts by weight of angle cap glue 8~17.
The second object of the present invention is to provide the method for preparing medicine of the present invention, including：
(a) honeysuckle, dried orange peel, Buddha's hand, peach kernel are boiled with decocting to obtain extract solution, Cornu Cervi cowl is added into the extract solution
Glue, medicinal extract is condensed into after dissolving, dries, drug particles are obtained after crushing；
(b) formulation needed for drug particles preparation.
The Chinese medicine composition that another aspect of the present invention is related to the present invention is being prepared for treating in the medicament of inflammatory reaction
Purposes.
Compared with prior art, beneficial effects of the present invention are：
(1) good drug efficacy, pure Chinese medicine formula, without obvious toxicity；
(2) medication in the form of Chinese medicine preparation, convenient to take, effect is good；
(3) inflammation can effectively be treated.
Embodiment
One aspect of the present invention is related to a kind of Chinese medicine composition containing Cornu Cervi cowl glue, is mainly made up of following raw material：Gold and silver
Flower, dried orange peel, Buddha's hand, peach kernel and Cornu Cervi cowl glue.
Preferably, Chinese medicine composition of the invention is mainly made up of the raw material of following proportioning：
The parts by weight of honeysuckle 6~14, the parts by weight of dried orange peel 6~14, the parts by weight of Buddha's hand 5~9, the parts by weight of peach kernel 1~4 and deer
The parts by weight of angle cap glue 8~17.
Preferably, Chinese medicine composition of the invention is mainly made up of the raw material of following proportioning：
The parts by weight of honeysuckle 8~12, the parts by weight of dried orange peel 8~12, the parts by weight of Buddha's hand 6~8, the parts by weight of peach kernel 2~3 and deer
The parts by weight of angle cap glue 10~15.
Preferably, Chinese medicine composition of the invention is mainly made up of the raw material of following proportioning：
The parts by weight of honeysuckle 9~11, the parts by weight of dried orange peel 9~11, the parts by weight of Buddha's hand 6.5~7.5, the weight of peach kernel 2.3~2.7
Part and the parts by weight of Cornu Cervi cowl glue 11~14.
Preferably, Chinese medicine composition of the invention is mainly made up of the raw material of following proportioning：
The parts by weight of honeysuckle 10, the parts by weight of dried orange peel 10, the parts by weight of Buddha's hand 7, the parts by weight of peach kernel 2.5 and the weight of Cornu Cervi cowl glue 13
Measure part.
In a preferred embodiment, medicine of the invention uses effective Chinese herbal medicine (10 grams of honeysuckle, dried orange peel 10
Gram, 7 grams of Buddha's hand, 3 grams of peach kernel, 13 grams of Cornu Cervi cowl glue)/agent.
First, raw material (component)
(1) honeysuckle
Honeysuckle, it is Caprifoliaceae woodbine honeysuckle Lonicera japonica and congener dry flower or band
The flower just opened.Honeysuckle is described as clearing heat and detoxicating good medicine from ancient times.The sweet cold air fragrance of its property, clear heat with drugs of sweet flavour and cold nature is without injuring one's stomach, fragrance
Reaching thoroughly again can eliminating evil.Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile diseases, such as body heat, dermexanthesis, send out spot,
The diseases such as heat toxin sore carbuncle, abscess of throat, equal effect are significant.
The amount of honeysuckle can be 6~14 parts by weight, preferably 8~12 parts by weight, more preferably 9~11 parts by weight, most preferably
10 parts by weight.
(2) dried orange peel
Dried orange peel is rutaceae orange Citrus reticulata Blanco and its dry mature skin of variety.
Orange peel medicinal material, in addition to the pericarp of above-mentioned tangerine class, the pericarp of mandarin orange class and sweet orange, also make orange peel use sometimes.
The amount of dried orange peel can be 6~14 parts by weight, preferably 8~12 parts by weight, more preferably 9~11 parts by weight, most preferably 10
Parts by weight.
(3) Buddha's hand
Buddha's hand is also known as bergamot C.m.var.sarcodactylis, is the mutation of citron, fruit each carpel in maturation
Separation, forms the fruit lobe of elongate curved, and shape such as finger is therefore named.Buddha's hand acrid flavour, hardship, acid, temperature, enter liver, through stomach have qi-regulating
The effect of phlegm.
The amount of Buddha's hand can be 5~9 parts by weight, preferably 6~8 parts by weight, more preferably 6.5~7.5 parts by weight, most preferably 7
Parts by weight.
(4) peach kernel
Peach kernel is the mature seed of peach or mountain peach.Function promoting blood circulation, relax bowel.
The amount of peach kernel can be 1~4 parts by weight, preferably 2~3 parts by weight, more preferably 2.3~2.7 parts by weight, most preferably
2.5 parts by weight.
(5) Cornu Cervi cowl glue
Cornu Cervi cowl has antitumor, the treatment proliferation of mammary gland, enhancing is immune, anti-oxidant, antifatigue, suppresses osteoporosis, promotees
Enter a variety of pharmacological activity such as skeletal injury reparation.
The amount of Cornu Cervi cowl glue can be 8~17 parts by weight, preferably 10~15 parts by weight, more preferably 11~14 parts by weight, most
It is preferred that 13 parts by weight.
(6) it is general to help medicine：Auxiliary material or excipient
The Chinese medicine composition of the present invention, which may further include, general helps medicine, such as auxiliary material or excipient.
Above-mentioned raw materials can be commercially available, can also be prepared according to the conventional method of this area.
2nd, form and formulation
In one embodiment, Chinese medicine composition of the invention can make the form of Chinese patent drug.The formulation of Chinese patent drug
Including but not limited to pill, powder, paste, tablet, granule (electuary), lozenge, capsule, aqua, tincture.
(1) pill
Pill is fine medicinal material powder or medicinal substances extract adds suitable binders or auxiliary material, manufactured spherical or spherical solid
Preparation, it is one of most ancient formulation of Chinese patent drug.It is divided into honeyed bolus, water-honeyed pill, the water-bindered pill, paste again according to the different pills of adhesive
The types such as ball, condensed pill, micropill.
It is preferred that use condensed pill.Condensed pill is the decocting liquid or extract solution of whole medicinal materials or part medicinal material, with suitable auxiliary material
Or fine drug powder adds suitable adhesive to be made.According to the difference of adhesive, it is divided into concentration honeyed bolus, the concentration water-bindered pill, condensed water again
Honeyed bolus.Condensed pill small volume, effective ingredient content is high, is easy to take, it is slower to dissolve absorptance in vivo.
In a preferred embodiment, by whole medicinal materials or the decocting liquid or extract solution of part medicinal material, with auxiliary material or medicine
Thing fine powder adds adhesive that condensed pill is made.Preferably, by whole medicinal material decocting liquids or extract solution and adhesive and optional auxiliary material system
Into condensed pill.
(2) powder
Powder is the powder preparation that one or more medicinal materials are mixed, and divides oral powder and external pulvis, is China
One of ancient times formulation.Powder therapeutic domain is wide, disperses soon, to prove effective rapid after taking, and with easy to make, easy to carry, section
The advantages that saving medicinal material.
(3) paste
One of paste system pharmaceutical dosage form.Paste is that medicine is decocted to the formulation for concentrating and forming with water or vegetable oil.Have for oral administration
With two kinds of external application.Cream for oral administration generally shunts medicinal extract, medicinal extract, three kinds of soft extracts again；External plaster has two kinds of ointment, plaster.It is wherein for oral administration
Soft extracts and externally-applied ointment are formulations common in paste.Soft extracts for oral administration is called cream taste, is to add decocting to endure medicine, filters dregs, adds
Enter rock sugar, honey etc., be boiled into the cream of stiff, can be long-term use of.It is usually used in chronic disease or person in poor health.The ointment of external application claims
Ointment, general ointment, it is that beeswax is added in cotton seed oil or peanut oil, heating fusing, multiplies the fine drug powder that heat adds application, no
Disconnected stirring, to be condensed.The readily volatilized medicine such as borneol, camphor, it can add and stir evenly after ointment is cold.External-applied ointment is typically used
In outer painting skin ulcer mange etc..
Present invention preferably uses soft extract, soft extract (cream taste) is that medicinal material is boiled with decocting, after concentration of removing slag, and adds sweetener system
Into semisolid preparation, also known as cream grow.Sweetener can be refined honey or sugar, xylitol, preferably xylitol.Soft extract, which has, to be absorbed
It hurry up, concentration is high, small volume, is easy to preserve, the characteristics of can taking the standby long period.There is nourishing conditioning, it is slow for treating
Venereal disease and weakness due to chronic disease person.
(4) tablet
Tablet is that fine medicinal material powder or extract suppress the Formulation formed, sub-dip cream with suitable auxiliary material or fine medicinal material powder
Piece, semi-extract tablets and full powder piece etc., are one of conventional modern formulations.Tablet volume is small, and dosage is accurate, and easy disintegrating comes into force soon,
And with production efficiency is high, cost is low, takes and the advantages of accumulating facilitates.Tablet is applied to various diseases.The present invention preferably makes
With medicinal extract piece.
(5) granule
Granule (electuary) be medicinal substances extract with suitable auxiliary material or with fine medicinal material powder made of granular formulations, be
The novel form to grow up on the basis of decoction, powder and syrup.There are two kinds of graininess and bulk, be divided into soluble, suspension
The different type such as property, effervescency and sugar-containing type, Sugarless type.Granule small volume, it is in light weight, take simply, in good taste, effect is fast
Speed, it is used for the medicine of the effects such as help, cough-relieving, heat-clearing.
Preferably, prepared during preparation using water extract (decocting liquid).
(6) lozenge
Lozenge is fine medicinal material powder and suitable amount of adhesive such as honey, glutinous rice flour or regulation shape is made using the viscosity of medicinal material in itself
The solid pharmaceutical preparation of shape.For oral administration or external application is available for, effect for oral administration approaches with starched pill, and external application applies affected part after using water or vinegar mill juice.
Holding in the mouth or the eyes is used lozenge type mostly.
Preferably, lozenge of the invention is lozenge for oral administration.
(7) capsule
Capsule includes hard capsule and soft capsule.
Hard capsule be by appropriate medicinal substances extract, medicinal substances extract dosing powder or auxiliary material be made uniform powder or
Grain, is filled in hard shell capsules and manufactured formulation.It is mainly oral.Hard shell capsules outward appearance is neat and artistic, is easy to swallow, and can cover medicine
The bad odor of thing, disintegration is fast, good absorbing.Suitable for photaesthesia, unstable or meet wet, thermally labile medicine, or there is spy
The medicine of different odor, or need the medicine of timing positioning release.Children, the medicine strong to gastric irritation should not be made
Capsule.
Soft capsule is by oils or is closed in capsule material to liquid medicine of the capsule materials such as gelatin without dissolution or suspension
Formulation made of interior.Feature is similar to hard shell capsules.Hard shell capsules and soft capsule handle by proper method or with other medicinal high scores
Sub- material processing, makes softgel shell not dissolve in gastric juice, but discharge active component is disintegrated in intestinal juice, is capsulae enterosolubilis.
Preferably, capsule of the invention be by decocting liquid obtain medicinal substances extract add auxiliary material be made uniform powder or
Grain, is filled in hard shell capsules and manufactured formulation.Capsule is convenient to take, and effective ingredient absorbs fast, long shelf-life, production work
Skill is simple, and a kind of preferable preparation method comprises the following steps
(8) tincture
Tincture be medicine normal concentration ethanol leach or dissolving made of supernatant liquid preparation, liquid extract can also be used
Dilution is made.It is divided to for oral administration and two kinds of external application.Tincture is prepared without heating, and composition is purer, and active constituent content is high, and dosage is accurate
Really, absorb rapidly, be suitable for preparing the preparation containing volatile ingredient or thermo-labile component.Preferably, tincture of the invention is
Tincture for oral administration.
3rd, purposes
The Chinese medicine composition that another aspect of the present invention is related to the present invention is being prepared for treating in the medicament of inflammatory reaction
Purposes.
4th, preparation method
Another aspect of the present invention is related to a kind of preparation method of Chinese medicine composition.
In one embodiment, the method for preparing the Chinese medicine composition of the present invention comprises the following steps：
(a) honeysuckle, dried orange peel, Buddha's hand, peach kernel are boiled with decocting to obtain extract solution, Cornu Cervi cowl is added into the extract solution
Glue, medicinal extract is condensed into after dissolving, dries, drug particles are obtained after crushing；
(b) formulation needed for drug particles preparation.
Formulation can be above-mentioned formulation, for example, pill, powder, paste, tablet, granule (electuary), lozenge, capsule,
Aqua or tincture.
Preferably, preparation method as described above, the quality of the water is the honeysuckle, dried orange peel, Buddha's hand, the total matter of peach kernel
10~30 times of amount；More preferably 15~25 times, or 20 times.
Preferably, preparation method as described above, described decoct is specially that boiling water decocts 50min~70min, is repeated 3 times,
Merging obtains the extract solution.
Most preferably, the Chinese medicine composition is capsule, by the drug particles cross after 80 mesh sieves and/or it is general help medicine without
Bacterium capsule charge both obtained.It is preferred that every 0.3g of capsule.
5th, take and curative effect explanation：
For above-mentioned capsule 2 tablets each time, 2 times a day.
It is of course also possible to take the Chinese patent drug formulation of other formulations.On the basis of above-mentioned decocting liquid dosage, Chinese patent drug formulation
Dose can be determined by clinical trial in the art.
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition suggested according to normal condition or manufacturer are carried out.Agents useful for same or the unreceipted production firm person of instrument, it is
The conventional products obtained can be bought by city.
Embodiment 1 (aqua)
Honeysuckle 6g, dried orange peel 14g, Buddha's hand 9g, peach kernel 1g are mixed, add 10 times of water of material, decoction obtains extract solution, to
Cornu Cervi cowl glue 8g is added in the extract solution, medicinal extract is condensed into after dissolving, dries, drug particles is obtained after crushing；
The drug particles are added into 1 liter of drinking water and stew boiling 30 minutes, 100mL is concentrated into, produces aqua.
Embodiment 2 (condensed pill)
Honeysuckle 14g, dried orange peel 6g, Buddha's hand 5g, peach kernel 4g are mixed, add 30 times of water of material, decoction obtains extract solution, to
Cornu Cervi cowl glue 17g is added in the extract solution, medicinal extract is condensed into after dissolving, dries, drug particles is obtained after crushing；
Add 1 liter of drinking water and stew boiling 60 minutes, be then concentrated into paste, make pelletization.
Embodiment 3 (tablet)
Honeysuckle 12g, dried orange peel 8g, Buddha's hand 8g, peach kernel 2g are mixed, add 30 times of water of material, decoction obtains extract solution, to
Cornu Cervi cowl glue 10g is added in the extract solution, medicinal extract is condensed into after dissolving, dries, drug particles is obtained after crushing；
The drug particles are participated in into lactose and magnesium stearate tabletting is made.
Embodiment 4 (capsule)
Honeysuckle 8g, dried orange peel 12g, Buddha's hand 6g, peach kernel 3g are mixed, add 10 times of water of material, decoction obtains extract solution, to
Cornu Cervi cowl glue 15g is added in the extract solution, medicinal extract is condensed into after dissolving, dries, drug particles is obtained after crushing；
The drug particles are crossed into sterile capsule charge after 80 mesh sieves, capsule is made.
Embodiment 5 (capsule)
Honeysuckle 10g, dried orange peel 10g, Buddha's hand 7g, peach kernel 2.5g are mixed, add 10~30 times of water of material, decoction is carried
Liquid is taken, Cornu Cervi cowl glue 13g is added into the extract solution, medicinal extract is condensed into after dissolving, dries, drug particles is obtained after crushing；
The drug particles are crossed into sterile capsule charge after 80 mesh sieves, capsule is made.
Every filling drug particles 0.3g of above-mentioned capsule.
Experimental example 1
This experimental example is investigated to therapeutic effect of the Chinese medicine composition provided by the present invention in thyroid disease.
Chronic lymphocytic thyroiditis (chronic lymphocytic thyroiditis, CLT) is also known as bridge this first
Shape adenositis (Hashimoto ' s thyroiditis, HT) or chronic lymphocytic thyroiditis, it is a kind of common AITD
(autoimmune thyroid diseases, AITDs), and the most important reason of Primary hypothyroidism.HT
It is organ specific autoimmune's property thyroid disease as caused by h and E factors.Its pathogenesis
Not yet thoroughly understand.It is now recognized that it is disease of multifactorial inheritance, its key factor is autoimmunity, can be with other LADAs
Disease is simultaneously deposited.During euthyroidism, TPO-Ab and TG-Ab concentration significantly increase, and are most to have diagnosis index.
1. diagnostic criteria：According to《Thyroid Diseases in China diagnosis and treatment guide》Chronic lymphocytic thyroiditis diagnosis mark
It is accurate：Every thyroid gland anthorisma, quality is tougher, particularly with isthmus pyramidal lobe enlargement, TPO-Ab and TG-Ab sun
Property, diagnosis establishment, including through thyroid fine needle aspiration cytolgical examination (FNAC) person of clarifying a diagnosis.Constitutional symptom meets the traditional Chinese medical science
The deficiency of vital energy deficiency of yang is dialectical：Weak, puffiness of face, fear cold, pale complexion, pale tongue, tongue are white, slow and sunken pulse etc.；Thyroid gland local symptom：Neck
Portion's pain or tenderness, foreign body in pharynx sense etc..
2. observation index
TPO-Ab, TG-Ab, thyroid function, clinical symptoms, safety indexes (blood routine and Liver and kidney function), thyroid gland
B ultrasound.Two groups of patients look into These parameters each 1 time when people organizes and after treating 3 months, and record pretherapy and post-treatment clinical symptoms.
3. patient's general information：The HT diseases that 93 patients are division of endocrinology's outpatient service in 2010~2015 years and ward is accepted for medical treatment
People, all patient's free triiodothyronines (FT3), free thyroxine (FT4), trilute (T3), four
Iodine thyronine (T4) is in normal range (NR)；The course of disease is average 1.41 ± 3.46 years.It is randomly divided into treatment group and control group is each
31, in treatment group, man 10, female 21；It is 25~65 years old age, average 42 ± 4.2 years old.In control group 1, man 15, female 16
Example；It is 21~78 years old age, average 47 ± 3.34 years old.In control group 3, man 13, female 18；23~75 years old age, average 43 ±
2.2 year.Three groups of general information compare that there was no significant difference (P>0.05), there is comparativity.
4 treatment methods
4.1 treatment group：The capsule that clothes for patients is prepared with embodiment 5,2 tablets each time, even served 3 months 2 times a day.
4.2 control group：The capsule that clothes for patients comparative example 1 and comparative example 2 are prepared 2 tablets each time, even served 32 times a day
Individual month；
The preparation method of comparative example 1 differs only in and Buddha's hand is removed in material component with embodiment 5；
The preparation method of comparative example 2 differs only in and peach kernel is removed in material component with embodiment 5.
As can be known from the above table, for experimental group, (P is substantially reduced before relatively being treated after TPO-Ab and TG-Ab treatments<0.01 or P<
0.01)；And 1 equal indifference of control group, also there is notable difference (P before relatively being treated after control group 2TPO-Ab and TG-Ab treatment<
0.05 or P<0.05), but reduction amplitude is significantly less than experimental group.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, but it will be understood by those within the art that：Its
The technical scheme described in foregoing embodiments can still be modified, either to which part or all technical characteristic
Carry out equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention skill
The scope of art scheme.
Claims (10)
1. a kind of Chinese medicine composition containing Cornu Cervi cowl glue, it is characterised in that the Chinese medicine composition is mainly by following proportioning
Raw material is made：
The parts by weight of honeysuckle 6~14, the parts by weight of dried orange peel 6~14, the parts by weight of Buddha's hand 5~9, the parts by weight of peach kernel 1~4 and Cornu Cervi cowl
The parts by weight of glue 8~17.
2. the Chinese medicine composition according to claim 1 containing Cornu Cervi cowl glue, it is characterised in that the Chinese traditional medicine composition owner
To be made up of the raw material of following proportioning：
The parts by weight of honeysuckle 8~12, the parts by weight of dried orange peel 8~12, the parts by weight of Buddha's hand 6~8, the parts by weight of peach kernel 2~3 and Cornu Cervi cowl
The parts by weight of glue 10~15.
3. the Chinese medicine composition according to claim 2 containing Cornu Cervi cowl glue, it is characterised in that the Chinese traditional medicine composition owner
To be made up of the raw material of following proportioning：
The parts by weight of honeysuckle 9~11, the parts by weight of dried orange peel 9~11, the parts by weight of Buddha's hand 6.5~7.5, the parts by weight of peach kernel 2.3~2.7 with
And the parts by weight of Cornu Cervi cowl glue 11~14.
4. the Chinese medicine composition according to claim 3 containing Cornu Cervi cowl glue, it is characterised in that the Chinese traditional medicine composition owner
To be made up of the raw material of following proportioning：
The parts by weight of honeysuckle 10, the parts by weight of dried orange peel 10, the parts by weight of Buddha's hand 7, the parts by weight of peach kernel 2.5 and the weight of Cornu Cervi cowl glue 13
Part.
5. the Chinese medicine composition according to claim 1 containing Cornu Cervi cowl glue, it is characterised in that the Chinese medicine composition enters
One step includes auxiliary material or excipient.
6. the Chinese medicine composition according to claim 1 containing Cornu Cervi cowl glue, the formulation of the Chinese medicine composition is pill,
Powder, paste, tablet, granule, lozenge, capsule, aqua or tincture.
7. the preparation method of the Chinese medicine composition containing Cornu Cervi cowl glue described in any one of claim 1~6, it is characterised in that
Including：
(a) honeysuckle, dried orange peel, Buddha's hand, peach kernel are boiled with decocting to obtain extract solution, Cornu Cervi cowl glue are added into the extract solution,
Medicinal extract is condensed into after dissolving, dries, drug particles is obtained after crushing；
(b) formulation needed for drug particles preparation.
8. preparation method according to claim 7, it is characterised in that the quality of the water is the honeysuckle, dried orange peel, Buddhist
10~30 times of hand, peach kernel gross mass.
9. preparation method according to claim 8, it is characterised in that the decoction specially boiling water decoction 50min~
70min, it is repeated 3 times, merging obtains the extract solution.
10. the Chinese medicine composition described in any one of claim 1~6 is preparing the use in being used to treat the medicament of inflammatory reaction
On the way；
Preferably, the inflammation is glandular inflammation.
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| CN111214567A (en) * | 2020-03-13 | 2020-06-02 | 中科花鹿农业发展有限公司 | Composition containing antler cap, preparation method and application thereof, and nourishing paste |
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| CN111214567A (en) * | 2020-03-13 | 2020-06-02 | 中科花鹿农业发展有限公司 | Composition containing antler cap, preparation method and application thereof, and nourishing paste |
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