CN113577236A - Traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up, preparation and preparation method thereof - Google Patents
Traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up, preparation and preparation method thereof Download PDFInfo
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- CN113577236A CN113577236A CN202111028566.1A CN202111028566A CN113577236A CN 113577236 A CN113577236 A CN 113577236A CN 202111028566 A CN202111028566 A CN 202111028566A CN 113577236 A CN113577236 A CN 113577236A
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Abstract
The invention provides a traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up, a preparation and a preparation method thereof, relating to the technical field of traditional Chinese medicines. The Chinese medicinal composition has effects of dispersing stagnated liver qi, regulating stomach, invigorating spleen, relieving alcoholism, refreshing and promoting urination, and has effects of protecting liver and invigorating stomach. The reasonable compatibility of the citron, the perilla leaves and the hovenia dulcis thunb can realize synergistic interaction, finally achieve the effect of soothing the liver and regulating the flow of qi, effectively avoid the influence of drunkenness on the esophagus, recover the motor function of the esophagus, avoid the relaxation of the muscles of the esophagus, avoid the phenomenon of increasing gastric acid, avoid the reduction of the gastric discharge function and ensure the stable progress of liver metabolism. The traditional Chinese medicine composition has the advantages that all raw materials are pure traditional Chinese medicines, have no toxic or side effect on human bodies, have no drug resistance, are different from components such as stimulants, vitamins and amino acids in chemical anti-alcohol medicines, are healthier and are beneficial to conditioning human bodies of users.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up, a preparation and a preparation method thereof.
Background
Sobering up, as the name suggests, is to wake up people from a drunk state to restore consciousness or self-control. Usually, the sobering is not natural, but the sobering substance is drunk before drinking wine to sober up, so that the conversion of acetaldehyde is accelerated, the decomposition of alcohol is promoted, the purpose of saving time and reducing the harm of alcohol to human bodies is achieved. In daily life, people are faced with forced excessive drinking, which not only easily causes liver injury and corresponding liver pathological changes, but also causes other diseases, especially physiological dysfunction and death of human body. Therefore, sobering up, protecting liver and stomach are very urgent.
At present, anti-alcohol products in the market mainly comprise chemical drugs and traditional Chinese medicine preparations, wherein most of the chemical drugs are components such as stimulants, vitamins and amino acids, and can quickly achieve the effects of anti-alcohol and sobering up, but most of the chemical drug anti-alcohol mechanisms can only promote alcohol decomposition to achieve a temporary relieving effect, so that the liver protection effect is hardly achieved, and the toxic and side effects are great. Most of the traditional Chinese medicine preparations also do not have the effects of protecting stomach and liver, can relieve alcoholism, but cannot play the role of regulating and nourishing liver and stomach fundamentally.
Therefore, there is a need to develop a drug for protecting liver and stomach and alleviating hangover, so as to condition the liver and stomach of a user while alleviating hangover.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up, which has the effects of soothing liver, regulating qi, regulating the middle warmer, strengthening spleen, relieving alcoholism and cooling and inducing diuresis.
The invention also aims to provide a traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up, which comprises the traditional Chinese medicine composition, and meanwhile, the traditional Chinese medicine preparation is taken as an oral preparation, is favorable for improving the drug effect and is convenient for a user to carry and use.
The invention also aims to provide a preparation method of the traditional Chinese medicine preparation for protecting liver, stomach and sobering up, which directly prepares the raw material powder into soft materials, granulates, tablets and packages to obtain the tablets.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
In a first aspect, the embodiment of the application provides a traditional Chinese medicine composition for protecting liver, stomach and sobering, which is mainly prepared from the following raw materials, by weight, 30-70 parts of citron powder, 30-70 parts of perilla leaf powder, 30-70 parts of hovenia dulcis thunb powder, 60-140 parts of radix puerariae powder, 30-70 parts of mulberry powder, 30-70 parts of sea buckthorn powder, 30-70 parts of dark plum powder, 30-70 parts of exocarpium citri rubrum powder, 10-30 parts of inulin, 10-30 parts of agastache powder, 5-15 parts of licorice powder, 30-70 parts of turmeric and 5-15 parts of corn oligopeptide powder.
In a second aspect, an embodiment of the present application further provides an aforementioned traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up, including the aforementioned traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up.
In a third aspect, an embodiment of the present application further provides a preparation method of the aforementioned traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up, including the following steps:
taking materials: weighing citron powder, perilla leaf powder, hovenia dulcis thunb powder, kudzu root powder, mulberry powder, sea buckthorn powder, dark plum powder, tangerine peel powder, inulin, agastache powder, liquorice powder, turmeric and corn oligopeptide powder according to the weight parts, and adding sorbitol powder to obtain a first component raw material;
preparing a soft material: putting the first component raw material into a trough type mixer, uniformly stirring for the first time, adding an ethanol solution, and stirring for the second time to obtain a dry and wet uniform soft material;
preparing particles: preparing the soft material into 18-mesh granules in a granulator, drying the granulated and formed granules in drying equipment, pouring the dried granules into a granulator, and sieving by a 16-mesh sieve to obtain finished granules;
tabletting: pouring the finished product granules into a mixer, adding magnesium stearate, mixing uniformly, standing, putting into a tablet press for tabletting, adding a film coating agent, and coating with purified hydrated slurry to obtain tablets;
packaging: and packaging the slices after bagging, bottling or aluminum-plastic packaging.
In summary, compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:
the traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up provided by the invention has the effects of soothing liver and regulating qi, regulating the middle warmer and strengthening spleen, relieving alcoholism and cooling and inducing diuresis, and can play roles of protecting liver and nourishing stomach while relieving alcoholism. The reasonable compatibility of the citron, the perilla leaves and the hovenia dulcis thunb can realize synergistic interaction, finally achieve the effect of soothing the liver and regulating the flow of qi, effectively avoid the influence of drunkenness on the esophagus, recover the motor function of the esophagus, avoid the relaxation of the muscles of the esophagus, avoid the phenomenon of increasing gastric acid, avoid the reduction of the gastric discharge function and ensure the stable progress of liver metabolism. The traditional Chinese medicine composition has the advantages that all raw materials are pure traditional Chinese medicines, have no toxic or side effect on human bodies, have no drug resistance, are different from components such as stimulants, vitamins and amino acids in chemical anti-alcohol medicines, are healthier and are beneficial to conditioning human bodies of users.
The traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up provided by the invention contains the traditional Chinese medicine composition, adopts an oral preparation mode, is more beneficial to exerting the drug effect, has no toxic or side effect on the body and no drug resistance, is different from components such as an excitant, vitamins and amino acids in a chemical sobering up medicine, is more healthy, and is beneficial to conditioning the body of a user.
In addition, the preparation method provided by the invention is simple in integral manufacture, convenient to popularize, high in production efficiency and good in tablet forming effect, and various machines in modern science and technology are reasonably applied.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
In a first aspect, the embodiment of the application provides a traditional Chinese medicine composition for protecting liver, stomach and sobering, which is mainly prepared from the following raw materials, by weight, 30-70 parts of citron powder, 30-70 parts of perilla leaf powder, 30-70 parts of hovenia dulcis thunb powder, 60-140 parts of radix puerariae powder, 30-70 parts of mulberry powder, 30-70 parts of sea buckthorn powder, 30-70 parts of dark plum powder, 30-70 parts of exocarpium citri rubrum powder, 10-30 parts of inulin, 10-30 parts of agastache powder, 5-15 parts of licorice powder, 30-70 parts of turmeric and 5-15 parts of corn oligopeptide powder.
Citron: is dried mature fruit of Rutaceae plant Citrus citrifolia L. or Citrus wilsonii Tanaka. Pungent, bitter, sour and warm in nature. It enters liver, spleen and lung meridians. To soothe the liver, regulate qi, relieve epigastric distention and resolve phlegm. Can be used for treating qi stagnation of liver and stomach, distending pain in chest and hypochondrium, fullness and distention in stomach and abdomen, emesis, belching, excessive phlegm and cough.
And (3) perilla leaves: is dried leaf (or with twig) of Perilla frutescens (L.) Britt. Pungent and warm. It enters lung and spleen meridians. Relieve exterior syndrome, dispel cold, move qi and harmonize stomach. Can be used for treating wind-cold type common cold, cough, emesis, vomiting of pregnancy, and fish and crab poisoning.
Raisin tree seed: is mature seed of Hovenia dulcis Thunnb, Hovenia acerba Lindl, and Hovenia trichocarpa Chun et Tsiang. Sweet in flavor and neutral in nature. Enters the stomach channel. Relieving alcoholism, quenching thirst, relieving restlessness, stopping vomiting, and facilitating urination and defecation. Can be used for treating alcoholic intoxication, polydipsia, emesis, and constipation.
Kudzu root: is dried root of Ohwi of Pueraria lobata (Willd.) Ohwi of Leguminosae. Sweet, pungent and cool. It enters spleen, stomach and lung meridians. Expelling pathogenic factors from muscles and skin, relieving fever, promoting salivation, quenching thirst, promoting eruption, invigorating yang, relieving diarrhea, dredging meridian passage, and relieving alcoholism. Can be used for treating fever, headache, stiffness and pain of neck and back, thirst, diabetes, measles without adequate eruption, dysentery due to heat evil, diarrhea, vertigo, headache, apoplexy, hemiplegia, thoracic obstruction, cardiodynia, and alcoholic injury.
Mulberry: is dried fruit cluster of Morus alba L. Sweet, sour and cold. It enters heart, liver and kidney meridians. Nourish yin and enrich blood, promote fluid production and moisten dryness. Can be used for treating liver and kidney yin deficiency, giddiness tinnitus, cardiopalmus insomnia, early white beard and hair, body fluid consumption thirst, internal heat diabetes, and constipation due to intestinal dryness.
Sea-buckthorn: is dried mature fruit of Hippophae rhamnoides L. Sour, astringent and warm. It enters spleen, stomach, lung and heart meridians. Invigorate spleen to promote digestion, relieve cough and eliminate phlegm, activate blood and dissipate blood stasis. Can be used for treating spleen deficiency, anorexia, abdominal pain due to dyspepsia, cough, excessive phlegm, thoracic obstruction, cardialgia, blood stasis, amenorrhea, traumatic injury, blood stasis, and swelling.
Dark plum: is dried near-ripe fruit of Prunus mume (Sieb.) Sieb. et Zucc. of Rosaceae. Sour, astringent and neutral. It enters liver, spleen, lung and large intestine meridians. Astringe lung, astringe intestine, promote fluid production and relieve ascaris. Can be used for treating lung deficiency, chronic cough, chronic diarrhea, dysentery, asthenia heat, diabetes, ascariasis, emesis, and abdominal pain.
Orange peel: is dried outer peel of Citrus reticulata Blanco of Rutaceae and its cultivar. Pungent, bitter and warm. It enters lung and spleen meridians. To regulate qi, relax middle energizer, dry dampness and resolve phlegm. Can be used for treating cough with excessive phlegm, food stagnation, alcohol impairment, nausea, and oppression.
Inulin: inulin is a reserve polysaccharide in plants, mainly comes from the plants, has been found to be more than 36000, comprises 11 families of dicotyledonous plants such as Compositae, Campanulaceae and Gentianaceae and 11 families of monocotyledonous plants such as Liliaceae and gramineae, and is a very ideal functional food ingredient.
Agastache rugosus: is aerial part of Pogostemmincablin (blanco) Benth. or Agastache Chegusos (Fisch. etMey) O.Ktze. Pungent in flavor and slightly warm in nature. It enters spleen, stomach and lung meridians. Fragrant, resolving turbidity, regulating the middle warmer, arresting vomiting, relieving exterior syndrome and clearing summer-heat. Can be used for treating damp obstruction in middle warmer, abdominal distention, emesis, summer-heat dampness exterior syndrome, early stage of damp-warm syndrome, fever, listlessness, chest distress, cold-dampness, summer-heat, abdominal pain, emesis, diarrhea, nasosinusitis, and headache.
Licorice root: is dried root and rhizome of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat, or Glycyrrhiza glabra L. Sweet and neutral. It enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
Turmeric: is dried rhizome of Curcuma Longa L of Zingiberaceae. Pungent, bitter and warm. It enters spleen and liver meridians. Break blood and move qi, dredge meridians to alleviate pain. Can be used for treating chest and hypochondrium stabbing pain, thoracic obstruction, cardialgia, dysmenorrhea, amenorrhea, abdominal mass, rheumatism, shoulder and arm pain, and traumatic injury with swelling and pain.
In some embodiments of the present invention, the traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up is mainly prepared from, by weight, 50 parts of citron powder, 50 parts of perilla leaf powder, 50 parts of hovenia dulcis thunb powder, 100 parts of pueraria root powder, 50 parts of mulberry powder, 50 parts of sea buckthorn powder, 50 parts of dark plum powder, 50 parts of tangerine peel powder, 20 parts of inulin, 20 parts of wrinkled gianthyssop powder, 10 parts of licorice powder, 50 parts of turmeric and 10 parts of corn oligopeptide powder.
In a second aspect, the embodiment of the present application further provides a traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up, which includes the aforementioned traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up.
In some embodiments of the present invention, the formulation is an oral formulation, and the formulation is a tablet, powder, pill, capsule, granule, or oral liquid.
In some embodiments of the present invention, the preparation is a tablet, the preparation further includes pharmaceutically acceptable excipients, the excipients are sorbitol powder and magnesium stearate, and the mass part ratio of the sorbitol powder to the magnesium stearate is 5: 1.
In a third aspect, an embodiment of the present application further provides a preparation method of the aforementioned traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up, including the following steps: taking materials: weighing citron powder, perilla leaf powder, hovenia dulcis thunb powder, kudzu root powder, mulberry powder, sea buckthorn powder, dark plum powder, tangerine peel powder, inulin, agastache powder, liquorice powder, turmeric and corn oligopeptide powder according to the weight parts, and adding sorbitol powder to obtain a first component raw material;
preparing a soft material: putting the first component raw material into a trough type mixer, uniformly stirring for the first time, adding an ethanol solution, and stirring for the second time to obtain a dry and wet uniform soft material;
preparing particles: preparing the soft material into 18-mesh granules in a granulator, drying the granulated and formed granules in drying equipment, pouring the dried granules into a granulator, and sieving by a 16-mesh sieve to obtain finished granules;
tabletting: pouring the finished product granules into a mixer, adding magnesium stearate, mixing uniformly, standing, putting into a tablet press for tabletting, adding a film coating agent, and coating with purified hydrated slurry to obtain tablets;
packaging: and packaging the slices after bagging, bottling or aluminum-plastic packaging.
In some embodiments of the present invention, in the step of preparing a soft material, the time of the first stirring is 10min to 20min, the time of the second stirring is 8min to 12min, and the concentration of the ethanol solution is 75%.
In some embodiments of the present invention, in the step of preparing the granules, the temperature of the heat drying is 45 ℃ to 60 ℃ and the drying time is 1.5h to 2.5 h.
In some embodiments of the present invention, in the step of preparing the granules, the moisture content of the shaped granules is measured after heat drying, and the moisture content is between 4% and 5%.
In some embodiments of the present invention, in the tabletting step, magnesium stearate is added and mixed uniformly, and then the mixture is left for 30 min.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The embodiment aims to provide a traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up, which is prepared from the following raw materials in parts by weight:
30g of citron powder, 30g of perilla leaf powder, 30g of hovenia dulcis thunb powder, 60g of kudzuvine root powder, 30g of mulberry powder, 30g of sea buckthorn powder, 30g of dark plum powder, 30g of exocarpium citri rubrum powder, 10g of inulin, 10g of wrinkled gianthyssop herb powder, 5g of licorice powder, 30g of turmeric and 5g of corn oligopeptide powder.
The traditional Chinese medicine preparation is a tablet and comprises pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials comprise sorbitol powder and magnesium stearate, and the mass part ratio of the sorbitol powder to the magnesium stearate is 5:1
The traditional Chinese medicine preparation is mainly prepared by the following steps:
taking materials: weighing citron powder, perilla leaf powder, hovenia dulcis thunb powder, kudzu root powder, mulberry powder, sea buckthorn powder, dark plum powder, tangerine peel powder, inulin, agastache powder, liquorice powder, turmeric and corn oligopeptide powder according to the weight parts, and adding sorbitol powder to obtain a first component raw material;
preparing a soft material: putting the first component raw material into a trough type mixer, uniformly stirring for the first time, adding an ethanol solution, and stirring for the second time to obtain a dry and wet uniform soft material;
preparing particles: preparing the soft material into 18-mesh granules in a granulator, drying the granulated and formed granules in drying equipment, pouring the dried granules into a granulator, and sieving by a 16-mesh sieve to obtain finished granules;
tabletting: pouring the finished product granules into a mixer, adding magnesium stearate, mixing uniformly, standing, putting into a tablet press for tabletting, adding a film coating agent, and coating with purified hydrated slurry to obtain tablets;
packaging: and bottling or aluminum-plastic packaging the slices.
In the step of preparing the soft material, the time of primary stirring is 10min, the time of secondary stirring is 8min, and the concentration of the ethanol solution is 75%.
In the step of preparing the particles, the temperature for heating and drying is 45 ℃ and the drying time is 1.5 h.
In the step of preparing the pellets, the moisture content of the molded pellets was measured after heating and drying, and the moisture content was about 4.5%.
In the tabletting step, magnesium stearate is added and mixed uniformly, and then the mixture is kept still for 30 min.
The reasonable compatibility of the citron, the perilla leaves and the hovenia dulcis thunb in the traditional Chinese medicine preparation can mutually cooperate to enhance the efficacy, finally achieve the effect of soothing the liver and regulating the flow of qi, effectively avoid the influence of drunkenness on the esophagus, recover the motor function of the esophagus, avoid the relaxation of the muscles of the esophagus, avoid the phenomenon of increasing gastric acid, avoid the reduction of the gastric discharge function and ensure the stable progress of the liver metabolism. The traditional Chinese medicine composition has the advantages that all raw materials are pure traditional Chinese medicines, have no toxic or side effect on human bodies, have no drug resistance, are different from components such as stimulants, vitamins and amino acids in chemical anti-alcohol medicines, are healthier and are beneficial to conditioning human bodies of users. The kudzuvine root and the mulberry can play a role in quenching thirst after being matched with each other, so that renal dysfunction caused by excessive drinking of users is avoided. The radix Puerariae and Glycyrrhrizae radix can be used for relieving fever and promoting alcohol production. Sea-buckthorn, dark plum, exocarpium citri rubrum, inulin, wrinkled gianthyssop and turmeric can respectively play the roles of protecting the stomach, regulating mouth feel and astringing, regulating qi and reducing phlegm, protecting the liver, eliminating dampness and benefiting the biliary tract and the disinfection of the liver.
Example 2
The embodiment aims to provide a traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up, which is prepared from the following raw materials in parts by weight:
40g of citron powder, 40g of perilla leaf powder, 40g of hovenia dulcis thunb powder, 80g of kudzuvine root powder, 40g of mulberry powder, 40g of sea buckthorn powder, 40g of dark plum powder, 40g of exocarpium citri rubrum powder, 15g of inulin, 15g of wrinkled gianthyssop herb powder, 7.5g of liquorice powder, 40g of turmeric and 7.5g of corn oligopeptide powder.
The traditional Chinese medicine preparation is a tablet and comprises pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials comprise sorbitol powder and magnesium stearate, and the mass part ratio of the sorbitol powder to the magnesium stearate is 5:1
The traditional Chinese medicine preparation is mainly prepared by the following steps:
taking materials: weighing citron powder, perilla leaf powder, hovenia dulcis thunb powder, kudzu root powder, mulberry powder, sea buckthorn powder, dark plum powder, tangerine peel powder, inulin, agastache powder, liquorice powder, turmeric and corn oligopeptide powder according to the weight parts, and adding sorbitol powder to obtain a first component raw material;
preparing a soft material: putting the first component raw material into a trough type mixer, uniformly stirring for the first time, adding an ethanol solution, and stirring for the second time to obtain a dry and wet uniform soft material;
preparing particles: preparing the soft material into 18-mesh granules in a granulator, drying the granulated and formed granules in drying equipment, pouring the dried granules into a granulator, and sieving by a 16-mesh sieve to obtain finished granules;
tabletting: pouring the finished product granules into a mixer, adding magnesium stearate, mixing uniformly, standing, putting into a tablet press for tabletting, adding a film coating agent, and coating with purified hydrated slurry to obtain tablets;
packaging: and bottling or aluminum-plastic packaging the slices.
In the step of preparing the soft material, the time for primary stirring is 12.5min, the time for secondary stirring is 9min, and the concentration of the ethanol solution is 75%.
In the step of preparing the particles, the temperature for heating and drying is 50 ℃, and the drying time is 1.75 h.
In the step of preparing the pellets, the moisture content of the molded pellets was measured after heating and drying, and the moisture content was about 4.5%.
In the tabletting step, magnesium stearate is added and mixed uniformly, and then the mixture is kept still for 30 min.
The reasonable compatibility of the citron, the perilla leaves and the hovenia dulcis thunb in the traditional Chinese medicine preparation can mutually cooperate to enhance the efficacy, finally achieve the effect of soothing the liver and regulating the flow of qi, effectively avoid the influence of drunkenness on the esophagus, recover the motor function of the esophagus, avoid the relaxation of the muscles of the esophagus, avoid the phenomenon of increasing gastric acid, avoid the reduction of the gastric discharge function and ensure the stable progress of the liver metabolism. The traditional Chinese medicine composition has the advantages that all raw materials are pure traditional Chinese medicines, have no toxic or side effect on human bodies, have no drug resistance, are different from components such as stimulants, vitamins and amino acids in chemical anti-alcohol medicines, are healthier and are beneficial to conditioning human bodies of users. The kudzuvine root and the mulberry can play a role in quenching thirst after being matched with each other, so that renal dysfunction caused by excessive drinking of users is avoided. The radix Puerariae and Glycyrrhrizae radix can be used for relieving fever and promoting alcohol production. Sea-buckthorn, dark plum, exocarpium citri rubrum, inulin, wrinkled gianthyssop and turmeric can respectively play the roles of protecting the stomach, regulating mouth feel and astringing, regulating qi and reducing phlegm, protecting the liver, eliminating dampness and benefiting the biliary tract and the disinfection of the liver.
Example 3
The embodiment aims to provide a traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up, which is prepared from the following raw materials in parts by weight:
50g of citron powder, 50g of perilla leaf powder, 50g of hovenia dulcis thunb powder, 100g of kudzuvine root powder, 50g of mulberry powder, 50g of sea buckthorn powder, 50g of dark plum powder, 50g of exocarpium citri rubrum powder, 20g of inulin, 20g of wrinkled gianthyssop herb powder, 10g of licorice powder, 50g of turmeric and 10g of corn oligopeptide powder.
The traditional Chinese medicine preparation is a tablet and comprises pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials comprise sorbitol powder and magnesium stearate, and the mass part ratio of the sorbitol powder to the magnesium stearate is 5:1
The traditional Chinese medicine preparation is mainly prepared by the following steps:
taking materials: weighing citron powder, perilla leaf powder, hovenia dulcis thunb powder, kudzu root powder, mulberry powder, sea buckthorn powder, dark plum powder, tangerine peel powder, inulin, agastache powder, liquorice powder, turmeric and corn oligopeptide powder according to the weight parts, and adding sorbitol powder to obtain a first component raw material;
preparing a soft material: putting the first component raw material into a trough type mixer, uniformly stirring for the first time, adding an ethanol solution, and stirring for the second time to obtain a dry and wet uniform soft material;
preparing particles: preparing the soft material into 18-mesh granules in a granulator, drying the granulated and formed granules in drying equipment, pouring the dried granules into a granulator, and sieving by a 16-mesh sieve to obtain finished granules;
tabletting: pouring the finished product granules into a mixer, adding magnesium stearate, mixing uniformly, standing, putting into a tablet press for tabletting, adding a film coating agent, and coating with purified hydrated slurry to obtain tablets;
packaging: and bottling or aluminum-plastic packaging the slices.
In the step of preparing the soft material, the time for primary stirring is 15min, the time for secondary stirring is 10min, and the concentration of the ethanol solution is 75%.
In the step of preparing the particles, the temperature for heating and drying is 55 ℃, and the drying time is 2 h.
In the step of preparing the pellets, the moisture content of the molded pellets was measured after heating and drying, and the moisture content was about 4.5%.
In the tabletting step, magnesium stearate is added and mixed uniformly, and then the mixture is kept still for 30 min.
The reasonable compatibility of the citron, the perilla leaves and the hovenia dulcis thunb in the traditional Chinese medicine preparation can mutually cooperate to enhance the efficacy, finally achieve the effect of soothing the liver and regulating the flow of qi, effectively avoid the influence of drunkenness on the esophagus, recover the motor function of the esophagus, avoid the relaxation of the muscles of the esophagus, avoid the phenomenon of increasing gastric acid, avoid the reduction of the gastric discharge function and ensure the stable progress of the liver metabolism. The traditional Chinese medicine composition has the advantages that all raw materials are pure traditional Chinese medicines, have no toxic or side effect on human bodies, have no drug resistance, are different from components such as stimulants, vitamins and amino acids in chemical anti-alcohol medicines, are healthier and are beneficial to conditioning human bodies of users. The kudzuvine root and the mulberry can play a role in quenching thirst after being matched with each other, so that renal dysfunction caused by excessive drinking of users is avoided. The radix Puerariae and Glycyrrhrizae radix can be used for relieving fever and promoting alcohol production. Sea-buckthorn, dark plum, exocarpium citri rubrum, inulin, wrinkled gianthyssop and turmeric can respectively play the roles of protecting the stomach, regulating mouth feel and astringing, regulating qi and reducing phlegm, protecting the liver, eliminating dampness and benefiting the biliary tract and the disinfection of the liver.
Example 4
The embodiment aims to provide a traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up, which is prepared from the following raw materials in parts by weight:
60g of citron powder, 60g of perilla leaf powder, 60g of hovenia dulcis thunb powder, 120g of kudzuvine root powder, 60g of mulberry powder, 60g of sea buckthorn powder, 60g of dark plum powder, 60g of exocarpium citri rubrum powder, 25g of inulin, 25g of wrinkled gianthyssop herb powder, 12.5g of licorice powder, 60g of turmeric and 12.5g of corn oligopeptide powder.
The traditional Chinese medicine preparation is a tablet and comprises pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials comprise sorbitol powder and magnesium stearate, and the mass part ratio of the sorbitol powder to the magnesium stearate is 5:1
The traditional Chinese medicine preparation is mainly prepared by the following steps:
taking materials: weighing citron powder, perilla leaf powder, hovenia dulcis thunb powder, kudzu root powder, mulberry powder, sea buckthorn powder, dark plum powder, tangerine peel powder, inulin, agastache powder, liquorice powder, turmeric and corn oligopeptide powder according to the weight parts, and adding sorbitol powder to obtain a first component raw material;
preparing a soft material: putting the first component raw material into a trough type mixer, uniformly stirring for the first time, adding an ethanol solution, and stirring for the second time to obtain a dry and wet uniform soft material;
preparing particles: preparing the soft material into 18-mesh granules in a granulator, drying the granulated and formed granules in drying equipment, pouring the dried granules into a granulator, and sieving by a 16-mesh sieve to obtain finished granules;
tabletting: pouring the finished product granules into a mixer, adding magnesium stearate, mixing uniformly, standing, putting into a tablet press for tabletting, adding a film coating agent, and coating with purified hydrated slurry to obtain tablets;
packaging: and bottling or aluminum-plastic packaging the slices.
In the step of preparing the soft material, the time for primary stirring is 17.5min, the time for secondary stirring is 11min, and the concentration of the ethanol solution is 75%.
In the step of preparing the granules, the temperature for heating and drying is 60 ℃, and the drying time is 2.25 h.
In the step of preparing the pellets, the moisture content of the molded pellets was measured after heating and drying, and the moisture content was about 4.5%.
In the tabletting step, magnesium stearate is added and mixed uniformly, and then the mixture is kept still for 30 min.
The reasonable compatibility of the citron, the perilla leaves and the hovenia dulcis thunb in the traditional Chinese medicine preparation can mutually cooperate to enhance the efficacy, finally achieve the effect of soothing the liver and regulating the flow of qi, effectively avoid the influence of drunkenness on the esophagus, recover the motor function of the esophagus, avoid the relaxation of the muscles of the esophagus, avoid the phenomenon of increasing gastric acid, avoid the reduction of the gastric discharge function and ensure the stable progress of the liver metabolism. The traditional Chinese medicine composition has the advantages that all raw materials are pure traditional Chinese medicines, have no toxic or side effect on human bodies, have no drug resistance, are different from components such as stimulants, vitamins and amino acids in chemical anti-alcohol medicines, are healthier and are beneficial to conditioning human bodies of users. The kudzuvine root and the mulberry can play a role in quenching thirst after being matched with each other, so that renal dysfunction caused by excessive drinking of users is avoided. The radix Puerariae and Glycyrrhrizae radix can be used for relieving fever and promoting alcohol production. Sea-buckthorn, dark plum, exocarpium citri rubrum, inulin, wrinkled gianthyssop and turmeric can respectively play the roles of protecting the stomach, regulating mouth feel and astringing, regulating qi and reducing phlegm, protecting the liver, eliminating dampness and benefiting the biliary tract and the disinfection of the liver.
Example 5
The embodiment aims to provide a traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up, which is prepared from the following raw materials in parts by weight:
70g of citron powder, 70g of perilla leaf powder, 70g of hovenia dulcis thunb powder, 140g of kudzuvine root powder, 70g of mulberry powder, 70g of sea buckthorn powder, 70g of dark plum powder, 70g of tangerine peel powder, 30g of inulin, 30g of wrinkled gianthyssop herb powder, 15g of licorice powder, 70g of turmeric and 15g of corn oligopeptide powder.
The traditional Chinese medicine preparation is a tablet and comprises pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials comprise sorbitol powder and magnesium stearate, and the mass part ratio of the sorbitol powder to the magnesium stearate is 5:1
The traditional Chinese medicine preparation is mainly prepared by the following steps:
taking materials: weighing citron powder, perilla leaf powder, hovenia dulcis thunb powder, kudzu root powder, mulberry powder, sea buckthorn powder, dark plum powder, tangerine peel powder, inulin, agastache powder, liquorice powder, turmeric and corn oligopeptide powder according to the weight parts, and adding sorbitol powder to obtain a first component raw material;
preparing a soft material: putting the first component raw material into a trough type mixer, uniformly stirring for the first time, adding an ethanol solution, and stirring for the second time to obtain a dry and wet uniform soft material;
preparing particles: preparing the soft material into 18-mesh granules in a granulator, drying the granulated and formed granules in drying equipment, pouring the dried granules into a granulator, and sieving by a 16-mesh sieve to obtain finished granules;
tabletting: pouring the finished product granules into a mixer, adding magnesium stearate, mixing uniformly, standing, putting into a tablet press for tabletting, adding a film coating agent, and coating with purified hydrated slurry to obtain tablets;
packaging: and bottling or aluminum-plastic packaging the slices.
In the step of preparing the soft material, the time of primary stirring is 20min, the time of secondary stirring is 12min, and the concentration of the ethanol solution is 75%.
In the step of preparing the particles, the temperature for heating and drying is 60 ℃, and the drying time is 2.5 h.
In the step of preparing the pellets, the moisture content of the molded pellets was measured after heating and drying, and the moisture content was about 4.5%.
In the tabletting step, magnesium stearate is added and mixed uniformly, and then the mixture is kept still for 30 min.
The reasonable compatibility of the citron, the perilla leaves and the hovenia dulcis thunb in the traditional Chinese medicine preparation can mutually cooperate to enhance the efficacy, finally achieve the effect of soothing the liver and regulating the flow of qi, effectively avoid the influence of drunkenness on the esophagus, recover the motor function of the esophagus, avoid the relaxation of the muscles of the esophagus, avoid the phenomenon of increasing gastric acid, avoid the reduction of the gastric discharge function and ensure the stable progress of the liver metabolism. The traditional Chinese medicine composition has the advantages that all raw materials are pure traditional Chinese medicines, have no toxic or side effect on human bodies, have no drug resistance, are different from components such as stimulants, vitamins and amino acids in chemical anti-alcohol medicines, are healthier and are beneficial to conditioning human bodies of users. The kudzuvine root and the mulberry can play a role in quenching thirst after being matched with each other, so that renal dysfunction caused by excessive drinking of users is avoided. The radix Puerariae and Glycyrrhrizae radix can be used for relieving fever and promoting alcohol production. Sea-buckthorn, dark plum, exocarpium citri rubrum, inulin, wrinkled gianthyssop and turmeric can respectively play the roles of protecting the stomach, regulating mouth feel and astringing, regulating qi and reducing phlegm, protecting the liver, eliminating dampness and benefiting the biliary tract and the disinfection of the liver.
Examples of effects
The purpose of this effect example is to verify the effects of the traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up provided in the foregoing examples.
1) Taking 120 male SPF Kunming mice (24 +/-2 g), dividing into 6 groups, wherein each group comprises 20 mice, feeding for 12 hours before each mouse experiment, and intragastrically administering 0.2ml/10g of 39 ℃ white spirit (equivalent to 200ml of adult drinking) to each experimental mouse;
2) after the wine is infused for 15min, the physiological saline for gastric lavage in 1 group and the Chinese medicinal preparation in experimental examples 1-5 in 2-6 groups are respectively tabletted, and meanwhile, the same dosage is ensured.
3) After the intragastric administration for 15min, the behavior index of the mouse is observed by adopting an intoxication experiment. Wherein, the drunkenness experiment: whether the mouse is drunk or not is indicated by whether the righting reflex (right reflex) disappears. After the mice are filled with the wine, the mice lie on the platform back and down, if the mice can not turn over the body by themselves within 30s, the positive reflection disappears, namely the mice are drunk, the number of drunk patients and the disappearance time and recovery time of the mouse positive reflection are recorded, and the drunk maintenance time (the disappearance time of the positive reflection to the recovery time) is calculated
The test results are shown in the following table.
As can be seen from the table, the drugs of example 3 in group 4 were used for the shortest time to alleviate hangover.
In summary, the traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up provided by the embodiment of the invention has the advantages that:
the traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up provided by the invention has the effects of soothing liver and regulating qi, regulating the middle warmer and strengthening spleen, relieving alcoholism, cooling and inducing diuresis, and can protect liver and nourish stomach while relieving alcoholism. The reasonable compatibility of the citron, the perilla leaves and the hovenia dulcis thunb can realize synergistic interaction, finally achieve the effect of soothing the liver and regulating the flow of qi, effectively avoid the influence of drunkenness on the esophagus, recover the motor function of the esophagus, avoid the relaxation of the muscles of the esophagus, avoid the phenomenon of increasing gastric acid, avoid the reduction of the gastric discharge function and ensure the stable progress of liver metabolism. The traditional Chinese medicine composition has the advantages that all raw materials are pure traditional Chinese medicines, have no toxic or side effect on human bodies, have no drug resistance, are different from components such as stimulants, vitamins and amino acids in chemical anti-alcohol medicines, are healthier and are beneficial to conditioning human bodies of users.
The traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up provided by the invention contains the traditional Chinese medicine composition, and an oral preparation mode is adopted, so that the traditional Chinese medicine preparation is more beneficial to exerting the drug effect, has no toxic or side effect on a body, has no drug resistance, is different from components such as an excitant, vitamins and amino acids in a chemical sobering up medicine, is more healthy, and is beneficial to conditioning the body of a user.
The preparation method provided by the invention has the advantages of simple integral manufacture, convenience for popularization, reasonable application of various machines in modern science and technology, high production efficiency and good tablet forming effect.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up is characterized by being mainly prepared from the following raw materials, by weight, 30-70 parts of citron powder, 30-70 parts of perilla leaf powder, 30-70 parts of hovenia dulcis thunb powder, 60-140 parts of radix puerariae powder, 30-70 parts of mulberry powder, 30-70 parts of sea buckthorn powder, 30-70 parts of dark plum powder, 30-70 parts of exocarpium citri rubrum powder, 10-30 parts of inulin, 10-30 parts of agastache rugosus powder, 5-15 parts of liquorice powder, 30-70 parts of turmeric and 5-15 parts of corn oligopeptide powder.
2. The traditional Chinese medicine composition for protecting liver, protecting stomach and sobering up as claimed in claim 1, is characterized by being mainly prepared from raw materials of, by weight, 50 parts of citron powder, 50 parts of perilla leaf powder, 50 parts of hovenia dulcis thunb powder, 100 parts of pueraria lobata powder, 50 parts of mulberry powder, 50 parts of sea buckthorn powder, 50 parts of dark plum powder, 50 parts of tangerine peel powder, 20 parts of inulin, 20 parts of wrinkled gianthyssop powder, 10 parts of licorice powder, 50 parts of turmeric and 10 parts of corn oligopeptide powder.
3. A Chinese medicinal preparation for protecting liver, protecting stomach and sobering up, which is characterized by comprising the Chinese medicinal composition for protecting liver, protecting stomach and sobering up as claimed in claim 1 or 2.
4. The traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up as claimed in claim 3, wherein the preparation is an oral preparation, and the preparation is a tablet, powder, pill, capsule, granule or oral liquid.
5. The traditional Chinese medicine preparation for protecting liver, protecting stomach and sobering up as claimed in claim 4, wherein the preparation is a tablet, the preparation further comprises pharmaceutically acceptable auxiliary materials, the auxiliary materials are sorbitol powder and magnesium stearate, and the mass part ratio of the sorbitol powder to the magnesium stearate is 5: 1.
6. A method for preparing the Chinese medicinal preparation for protecting liver, stomach and sobering up as claimed in claim 5, comprising the steps of:
taking materials: weighing citron powder, perilla leaf powder, hovenia acerba powder, kudzu root powder, mulberry powder, sea buckthorn powder, dark plum powder, tangerine powder, inulin, agastache powder, licorice powder, turmeric and corn oligopeptide powder according to the weight parts, and adding sorbitol powder to obtain a first component raw material or respectively taking single medicinal materials to mix, extract, dry and crush into mixed medicinal powder to obtain a first component raw material;
preparing a soft material: uniformly putting the first component raw materials into a mixer, adding an ethanol solution, and stirring to obtain a dry and wet uniform soft material;
preparing particles: preparing the soft material into 18-mesh granules in a granulator, drying the granulated and formed granules in drying equipment, pouring the dried granules into a granulator, and sieving by a 16-mesh sieve to obtain finished granules;
tabletting: pouring the finished product granules into a mixer, adding magnesium stearate, mixing uniformly, standing, putting into a tablet press for tabletting, adding a film coating agent, and coating with purified hydrated slurry to obtain tablets;
packaging: and packaging the slices after bagging, bottling or aluminum-plastic packaging.
7. The method according to claim 6, wherein in the step of preparing the soft material, the time for the first stirring is 10min to 20min, the time for the second stirring is 8min to 12min, and the concentration of the ethanol solution is 75%.
8. The method according to claim 6, wherein in the step of preparing the granules, the temperature of the heat drying is 45 ℃ to 60 ℃ and the drying time is 1.5h to 2.5 h.
9. The method of claim 8, wherein in the step of preparing the granules, the moisture content of the shaped granules is measured after drying by heating to be 4% to 5%.
10. The preparation method according to claim 6, wherein in the tabletting step, magnesium stearate is added and mixed uniformly, and then the mixture is left for 30 min.
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