CN101897785A - Pharmaceutical composition with acne-dispelling function and preparation method thereof - Google Patents
Pharmaceutical composition with acne-dispelling function and preparation method thereof Download PDFInfo
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- CN101897785A CN101897785A CN2009100862233A CN200910086223A CN101897785A CN 101897785 A CN101897785 A CN 101897785A CN 2009100862233 A CN2009100862233 A CN 2009100862233A CN 200910086223 A CN200910086223 A CN 200910086223A CN 101897785 A CN101897785 A CN 101897785A
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Abstract
The invention discloses a pharmaceutical composition with an acne-dispelling function and a preparation method thereof. The pharmaceutical composition is prepared by the following components based on a certain weight ratio: honeysuckle flower, rhubarb, fructus gardeniae, white mulberry root-bark, radix angelicae and loguat leaf. The pharmaceutical composition is made into soft capsules and has an acne-dispelling efficacy.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, belong to medicine or field of health care food with acne-dispelling function.
Background technology
Acne is commonly called as " acne ", " comedo ", it is a kind of teen-age chronic skin inflammation that is mainly in, the development of the popularity of acne investigation in recent years, the teenager sickness rate in 11-25 year reaches more than 80%, adolescence's sickness rate of 25-35 reaches more than 15%, as untimely treatment or prevent and treat improperly, can leave over the cicatrix that lifelong difficulty heals, thereby influence appearance, make numerous young patients very worried.The occurrence cause more complicated of acne, relevant with multiple factor, unreasonable as dietary structure, psychentonia, the viscera function disorder, life or working environment are not good, some trace element deficiency, inherited genetic factors, constipation etc., but main cause still is an adolescence reaches maturity, and the androgen level raises in the body, and the epithelial cell that chafe and hair follicle come off is gathered into yellow-white material thromboembolism in hair follicle, promptly form acne, young as hair follicle, sebum is difficult to discharge and the little pimple of canescence that forms, is hoary hair's acne.The acne that are exposed to the follicular orifice outside are blackhead because of air, dust, atmospheric pollution become black.The follicular canal intracavity also exists a large amount of propionibacterium acness in addition, sebum can be resolved into unsaturated fatty acid, cause hair follicle and the not inflammation of equal extent takes place on every side, and suppuration, tuberosity, cyst or sebaceous cyst etc. appear, prolonged and repeated inflammation can stay the cicatrix that difficulty heals on the face, makes the skin injustice, coarse ugly, and sebaceous secretion is smooth and inflammation repeatedly, increases the weight of to stimulate sebaceous secretion again, thereby forms vicious cycle.The traditional Chinese medical science thinks, acne is because patient's eating and drinking without temperance, and surfeit is pungent rich, causes stomach and large intestine intenseness of heat, the pyretic toxicity inner product, on attack in lung, steam in face, the diseases caused by exogenous pathogenic factor poison is evil, causes the heat in blood stasis at last, pents up skin and forms.
Summary of the invention
The invention provides a kind of new pharmaceutical composition, said composition has the function of the acne of dispelling.
Another object of the present invention provides the preparation method of aforementioned pharmaceutical compositions.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Flos Lonicerae 5-30 part, Radix Et Rhizoma Rhei 5-20 part, Fructus Gardeniae 5-20 part, Cortex Mori 5-20 part, Radix Angelicae Dahuricae 5-20 part, Folium Eriobotryae 10-30 part.
The preferred weight portion proportioning of described pharmaceutical composition is:
Flos Lonicerae 15-20 part, Radix Et Rhizoma Rhei 10-15 part, Fructus Gardeniae 10-15 part, Cortex Mori 10-15 part, Radix Angelicae Dahuricae 10-15 part, Folium Eriobotryae 20-25 part.
Preparation of drug combination method of the present invention is as follows:
Flos Lonicerae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Cortex Mori, the Radix Angelicae Dahuricae, Folium Eriobotryae are decocted with water twice, filter, merge extractive liquid, concentrates, drying is pulverized, and sieves, add appropriate amount of auxiliary materials, be prepared into pharmaceutically acceptable oral formulations, for example capsule, tablet, pill, granule, powder etc.Preferred soft capsule dosage form.
The preparation method of the preferred soft capsule of pharmaceutical composition of the present invention is as follows:
Flos Lonicerae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Cortex Mori, the Radix Angelicae Dahuricae, Folium Eriobotryae are added 6-8 times of water gaging decoct twice, be respectively 1.5 hours, 1 hour, filter merge extractive liquid,, it is 1.10-1.15 that filtrate is concentrated into relative density, and vacuum drying gets dry extract, pulverizes, sieve, get the extract powder, standby; Get an amount of Cera Flava and put in the soybean oil, be heated to fusion, put be chilled to room temperature after, add said extracted thing powder, grind well with colloid mill, medicinal liquid; Other gets gelatin, glycerol, water, antiseptic and puts in right amount and be heated to 80 ℃ of dissolvings in the appropriate vessel, filter, rubber solution, 60 ℃ of insulations are standby; Get above-mentioned medicinal liquid and rubber solution, be pressed into ball, be drying to obtain with the soft capsule production equipment.
In pharmaceutical composition of the present invention, the mechanism of action of each medicine is as follows:
Flos Lonicerae: sweet in the mouth, cold in nature, return lung, the heart, stomach warp.Have heat-clearing and toxic substances removing, the effect of wind-heat dissipating can be used for the carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease heating etc.The traditional Chinese medical science thinks, Flos Lonicerae is cold in nature, sweet in the mouth, gas are flat, has the effect of heat-clearing and toxic substances removing, can treat diseases such as pyretic toxicity abscess, carbuncle furuncle.Compendium of Material Medica is carried " Flos Lonicerae is good at removing toxic substances, so control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating of treatment epidemic febrile disease, and toxic-heat and blood stasis, diseases such as carbuncle and ulcer also are used for diseases such as anemopyretic cold, bronchitis.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, analgesic, regulate effect such as immunity.
Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, return spleen, stomach, large intestine, liver, pericardium channel.Have purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, the effect of eliminating blood stasis and inducing menstruation can be used for treating the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage etc.
Fructus Gardeniae: bitter in the mouth, cold in nature, GUIXIN, lung, tri-jiao channel.Have the pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, the effect of removing pathogenic heat from blood and toxic substance from the body, it is vexed to can be used for calentura, the jaundice dark coloured urine, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.Gently up clearly, the energy purte the white goes the flesh exterior heat, when fever caused by exogenous pathogenic factors, table heat in the interior, can play a part bilingual; This product purging with bitter and cold drugs can be let out the three warmers fire again, the removing heat from blood heat that clears away heart-fire, and it is vexed to can be used for calentura; Diseases such as bleeding due to blood-heat and pyretic stranguria hematuria.So Fructus Gardeniae can clearing heat in QI system, branch heat can purify the blood again.
Cortex Mori: sweet in the mouth, cold in nature, return lung meridian.Have eliminating pathogen from the lung for relieving asthma, the effect of inducing diuresis to remove edema can be used for the cough due to lung-heat, the edema of the face, diseases such as dysuria.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature, return lung, spleen, stomach warp.Have and dispel the wind, dampness, detumescence, the analgesic effect can be used for the treatment headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Be used for the treatment of skin infection, first time-out can eliminating stagnation, can evacuation of pus after bursting, studies show that the effect of skin moistening reduce wrinkle.
Folium Eriobotryae: bitter in the mouth, cold nature attaches to the lung and stomach meridians.Have clearing away lung-heat to relieve cough, the effect of stopping nausea and vomiting by lowering the adverse flow of QI is used for the cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastropyretic vomiting, hiccup etc.
The present invention thinks to become the various acne integrated use heat-clearing and toxic substances removing due to the one mutually because of heat, wet, expectorant, the stasis of blood, poison to the traditional Chinese medical science, and the treatment Fang Ze of promoting diuresis with drugs of tasteless flavour, blood stasis-eliminating and stagnation-dissipating carries out making behind the science compatibility.
Below, foregoing of the present invention is described in further detail by the specific embodiment:
Concrete embodiment
Embodiment 1:
18 parts of Flos Loniceraes, 12 parts of Radix Et Rhizoma Rhei, 12 parts of Fructus Gardeniaes, 12 parts of Cortex Mori, 12 parts of the Radixs Angelicae Dahuricae, 22 parts of Folium Eriobotryaes
Flos Lonicerae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Cortex Mori, the Radix Angelicae Dahuricae, Folium Eriobotryae are added 8 times of water gagings decoct twice, be respectively 1.5 hours, 1 hour, filter merge extractive liquid,, it is 1.10-1.15 that filtrate is concentrated into relative density, and vacuum drying gets dry extract, pulverizes, sieve, get the extract powder, standby; Get an amount of Cera Flava and put in the soybean oil, be heated to fusion, put be chilled to room temperature after, add said extracted thing powder, grind well with colloid mill, medicinal liquid; Other gets gelatin, glycerol, water, antiseptic and puts in right amount and be heated to 80 ℃ of dissolvings in the appropriate vessel, filter, rubber solution, 60 ℃ of insulations are standby; Get above-mentioned medicinal liquid and rubber solution, be pressed into ball, be drying to obtain with the soft capsule production equipment.
Embodiment 2:
15 parts of Flos Loniceraes, 10 parts of Radix Et Rhizoma Rhei, 14 parts of Fructus Gardeniaes, 14 parts of Cortex Mori, 11 parts of the Radixs Angelicae Dahuricae, 20 parts of Folium Eriobotryaes
Flos Lonicerae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Cortex Mori, the Radix Angelicae Dahuricae, Folium Eriobotryae are added 8 times of water gagings decoct twice, be respectively 1.5 hours, 1 hour, filter merge extractive liquid,, it is 1.10-1.15 that filtrate is concentrated into relative density, and vacuum drying gets dry extract, pulverizes, sieve, get the extract powder, standby; Get an amount of Cera Flava and put in the soybean oil, be heated to fusion, put be chilled to room temperature after, add said extracted thing powder, grind well with colloid mill, medicinal liquid; Other gets gelatin, glycerol, water, antiseptic and puts in right amount and be heated to 80 ℃ of dissolvings in the appropriate vessel, filter, rubber solution, 60 ℃ of insulations are standby; Get above-mentioned medicinal liquid and rubber solution, be pressed into ball, be drying to obtain with the soft capsule production equipment.
Embodiment 3:
20 parts of Flos Loniceraes, 10 parts of Radix Et Rhizoma Rhei, 15 parts of Fructus Gardeniaes, 12 parts of Cortex Mori, 12 parts of the Radixs Angelicae Dahuricae, 24 parts of Folium Eriobotryaes
Flos Lonicerae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Cortex Mori, the Radix Angelicae Dahuricae, Folium Eriobotryae are added 8 times of water gagings decocted 1.5 hours, add 6 times of water gagings twice to decoct 1 hour, filter merge extractive liquid,, it is 1.10-1.15 that filtrate is concentrated into relative density, and vacuum drying gets dry extract, pulverizes, sieve, get the extract powder, standby; Get an amount of Cera Flava and put in the soybean oil, be heated to fusion, put be chilled to room temperature after, add said extracted thing powder, grind well with colloid mill, medicinal liquid; Other gets gelatin, glycerol, water, antiseptic and puts in right amount and be heated to 80 ℃ of dissolvings in the appropriate vessel, filter, rubber solution, 60 ℃ of insulations are standby; Get above-mentioned medicinal liquid and rubber solution, be pressed into ball, be drying to obtain with the soft capsule production equipment.
Embodiment 4:
18 parts of Flos Loniceraes, 15 parts of Radix Et Rhizoma Rhei, 14 parts of Fructus Gardeniaes, 11 parts of Cortex Mori, 11 parts of the Radixs Angelicae Dahuricae, 21 parts of Folium Eriobotryaes
Flos Lonicerae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Cortex Mori, the Radix Angelicae Dahuricae, Folium Eriobotryae are added 8 times of water gagings decocted 1.5 hours, add 6 times of water gagings twice to decoct 1 hour, filter merge extractive liquid,, it is 1.10-1.15 that filtrate is concentrated into relative density, and vacuum drying gets dry extract, pulverizes, sieve, get the extract powder, standby; Get an amount of Cera Flava and put in the soybean oil, be heated to fusion, put be chilled to room temperature after, add said extracted thing powder, grind well with colloid mill, medicinal liquid; Other gets gelatin, glycerol, water, antiseptic and puts in right amount and be heated to 80 ℃ of dissolvings in the appropriate vessel, filter, rubber solution, 60 ℃ of insulations are standby; Get above-mentioned medicinal liquid and rubber solution, be pressed into ball, be drying to obtain with the soft capsule production equipment.
Further set forth the beneficial effect of pharmaceutical composition of the present invention by following experiment.
In order to show that pharmaceutical composition of the present invention is to the remedy of acne effect, systematically selected the case of patients with acne of all ages and classes different sexes of pimple, pustular, nodositas, cyst, utilize medicine of the present invention to treat, be 30 days a course of treatment.
Criterion of therapeutical effect:
1, the criterion of therapeutical effect of judging for pimple, acne nodosum
Cure: pimple, tuberosity disappear fully, and transference cure does not have recurrence in 1 year.
Produce effects: skin lesion disappears more than 80%, and symptom disappears substantially, does not have recurrence in 1 year.
Effectively: skin lesion disappears more than 60%, and symptom is most of to disappear, and does not have recurrence in 1 year.
Invalid: the skin lesion less than 20% that disappears, symptom does not have obvious improvement, or recurrence is as before in 1 year after the drug withdrawal.
2, the criterion of therapeutical effect of judging for pustular, acne cystica
Cure: pustule, cyst etc. disappears fully, and transference cure does not have recurrence in 2 years.
Produce effects: skin lesion disappears more than 80%, and symptom disappears substantially, does not have recurrence in 2 years.
Effectively: skin lesion disappears more than 60%, and symptom is most of to disappear, and does not have recurrence in 2 years.
Invalid: the skin lesion less than 20% that disappears, symptom does not have obvious improvement, or recurrence is as before in 2 years after the drug withdrawal.
The concrete outcome 1-4 that sees the following form.
The clinical data statistics of the therapeutic effect of table 1 acne papulosa
The clinical data statistics of the therapeutic effect of table 2 acne nodosum
The clinical data statistics of the therapeutic effect of table 3 pustular acne
The clinical data statistics of the therapeutic effect of table 4 acne cystica
More than 90%, and treating both the principal and secondary aspects of a disease is difficult for recurrence by the various types of acne effective percentage of the visible Drug therapy of the present invention of above clinical statistics data, instant effect, and good effect, toxic and side effects is little.To sum up, pharmaceutical composition of the present invention has the effect of the acne of well dispelling.
Claims (5)
1. the pharmaceutical composition with acne-dispelling function is characterized in that, it is to be made by following bulk drugs: Flos Lonicerae 5-30 part, Radix Et Rhizoma Rhei 5-20 part, Fructus Gardeniae 5-20 part, Cortex Mori 5-20 part, Radix Angelicae Dahuricae 5-20 part, Folium Eriobotryae 10-30 part.
2. pharmaceutical composition according to claim 1 is characterized in that, it is to be made by following bulk drugs: Flos Lonicerae 15-20 part, Radix Et Rhizoma Rhei 10-15 part, Fructus Gardeniae 10-15 part, Cortex Mori 10-15 part, Radix Angelicae Dahuricae 10-15 part, Folium Eriobotryae 20-25 part.
3. claim 1 or 2 described preparation of drug combination methods is characterized in that this method is:
Flos Lonicerae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Cortex Mori, the Radix Angelicae Dahuricae, Folium Eriobotryae are decocted with water twice, filter, merge extractive liquid, concentrates, drying is pulverized, and sieves, add appropriate amount of auxiliary materials, be prepared into pharmaceutically acceptable oral formulations, for example capsule, tablet, pill, granule, powder etc.Preferred soft capsule dosage form.
4. according to the described preparation of drug combination method of claim 3, it is characterized in that this method is:
Flos Lonicerae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Cortex Mori, the Radix Angelicae Dahuricae, Folium Eriobotryae are added 6-8 times of water gaging decoct twice, be respectively 1.5 hours, 1 hour, filter merge extractive liquid,, it is 1.10-1.15 that filtrate is concentrated into relative density, and vacuum drying gets dry extract, pulverizes, sieve, get the extract powder, standby; Get an amount of Cera Flava and put in the soybean oil, be heated to fusion, put be chilled to room temperature after, add said extracted thing powder, grind well with colloid mill, medicinal liquid; Other gets gelatin, glycerol, water, antiseptic and puts in right amount and be heated to 80 ℃ of dissolvings in the appropriate vessel, filter, rubber solution, 60 ℃ of insulations are standby; Get above-mentioned medicinal liquid and rubber solution, be pressed into ball, be drying to obtain with the soft capsule production equipment.
5. claim 1 or 2 described pharmaceutical compositions are used to prepare the medicine with acne-dispelling function or the application of health food.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100862233A CN101897785A (en) | 2009-05-27 | 2009-05-27 | Pharmaceutical composition with acne-dispelling function and preparation method thereof |
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| CN2009100862233A CN101897785A (en) | 2009-05-27 | 2009-05-27 | Pharmaceutical composition with acne-dispelling function and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099905A (en) * | 2013-02-26 | 2013-05-15 | 苏州市洋海电子有限公司 | Spleen deficiency and dampness abundance type acne treatment drug |
| CN103099904A (en) * | 2013-02-26 | 2013-05-15 | 苏州市洋海电子有限公司 | Traditional Chinese medicine preparation |
| CN104645138A (en) * | 2014-01-24 | 2015-05-27 | 潍坊医学院 | Medicine for treating chronic acnes |
| CN105412415A (en) * | 2015-12-21 | 2016-03-23 | 荥阳市藤本保健品有限公司 | Medicine composition removing acnes |
| CN106668762A (en) * | 2016-12-12 | 2017-05-17 | 金乡县金醫堂保健食品有限公司 | Traditional Chinese medicinal preparation with effect of removing chloasma, sore-toxin and acnes |
-
2009
- 2009-05-27 CN CN2009100862233A patent/CN101897785A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099905A (en) * | 2013-02-26 | 2013-05-15 | 苏州市洋海电子有限公司 | Spleen deficiency and dampness abundance type acne treatment drug |
| CN103099904A (en) * | 2013-02-26 | 2013-05-15 | 苏州市洋海电子有限公司 | Traditional Chinese medicine preparation |
| CN104645138A (en) * | 2014-01-24 | 2015-05-27 | 潍坊医学院 | Medicine for treating chronic acnes |
| CN104645138B (en) * | 2014-01-24 | 2018-05-15 | 潍坊医学院 | A kind of medicine for treating refractory acne |
| CN105412415A (en) * | 2015-12-21 | 2016-03-23 | 荥阳市藤本保健品有限公司 | Medicine composition removing acnes |
| CN106668762A (en) * | 2016-12-12 | 2017-05-17 | 金乡县金醫堂保健食品有限公司 | Traditional Chinese medicinal preparation with effect of removing chloasma, sore-toxin and acnes |
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Application publication date: 20101201 |