CN102018650A - Plant active essence - Google Patents
Plant active essence Download PDFInfo
- Publication number
- CN102018650A CN102018650A CN 201010512623 CN201010512623A CN102018650A CN 102018650 A CN102018650 A CN 102018650A CN 201010512623 CN201010512623 CN 201010512623 CN 201010512623 A CN201010512623 A CN 201010512623A CN 102018650 A CN102018650 A CN 102018650A
- Authority
- CN
- China
- Prior art keywords
- skin care
- skin
- care item
- parts
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics, relating to a skin care product-BASILCON facial treatment essence plant active essence containing natural effective ingredients. The plant active essence comprises the following components: wheat germ hydrolysate, fresh water pearl hydrolyzate grape seed oil, grapestone protein, hippophae rhamnoides extract and bee pollen. In the skin care product provided by the invention, the wheat germ hydrolysate, fresh water pearl hydrolyzate, grapestone protein and the like provide various amino acids and trace elements, and the organic existence of various nutrient components accelerates adsorption of skins, accelerates synthesis of in vivo collagen, regulates the cell metabolic function, strengthens cell activity and accelerates cell viability regeneration. In addition, the invention can obtain the effect on dermis layer moisturizing and moisture retaining, strengthens skin elasticity and alleviates skin aging.
Description
Technical field
The invention belongs to cosmetic field, relate to a kind of skin care item that contain natural constituent.
Background technology
Aging is the process that each tissue of body, organ dysfunction go down.Skin is one of the most tangible organ in the body aging process, and many types of collagen component content descends in the skin, causes skin toughness and elasticity to reduce, and wrinkle appears in skin, and is coarse dark and gloomy, lackluster, the aging aggravation.The performance of these skin agings generally is subjected to the repulsion at heart of masculinity femininity, and therefore, the aged skin care item of delaying skin are the focuses of beauty treatment fields research always.
Summary of the invention
The objective of the invention is to situation, provide a kind of and can effectively strengthen skin elasticity and the aged daily skin care item of delaying skin at prior art.
The present invention is achieved through the following technical solutions above-mentioned purpose.
Invention provides a kind of skin care item---and the refreshing bright water vegetable active essence of BASILCON comprises following component: Fructus Tritici aestivi hydrolysate, mussel pearl hydrolyzed solution, Oleum Vitis viniferae, Semen Vitis viniferae albumen, Fructus Hippophae extract.
The Fructus Tritici aestivi hydrolysate is to be obtained by following method: with after the Fructus Tritici aestivi defat as substrate, add papain and water, carry out enzyme digestion reaction, reconcentration or dry and get; In the described enzyme digestion reaction, the concentration of substrate is mass fraction 6%-9%; Enzyme concentration 2000-3000U/g; 55 ℃ of hydrolysis temperatures; Enzymolysis time is 40-50min.
The mussel pearl hydrolyzed solution is to make by the following method: get 30～35 parts of fresh water pearl powders, add 100 parts of water, add 2～3 parts of trypsin hydrolyzing after-filtration and get; Hydrolysis temperature is 45-48 ℃.
Fructus Hippophae extract is after sea buckthorn fruit is pulverized, to add ethanol water (alcoholic acid mass fraction is 60-90%) and extract (microwave extraction 4-8 minute), and extracting solution concentrates and obtains; The ethanol water that the Fructus Hippophae of every 1-2 part weight adds 3-6 part weight extracts.
The product that Oleum Vitis viniferae and Semen Vitis viniferae albumen all can adopt the market to buy.Semen Vitis viniferae albumen also can obtain by the following method: after the Semen Vitis viniferae raw material pulverizing, solvent extraction is gone out Oleum Vitis viniferae, the remaining Semen Vitis viniferae dregs of rice dissolve down at 40-50 ℃ with NaOH solution earlier, centrifugalize, precipitate with salt after getting supernatant, adjusting pH value again is 3.8, and centrifugalize obtains precipitate, is drying to obtain Semen Vitis viniferae albumen.
Described composition weight proportioning constitutes: the Fructus Tritici aestivi hydrolysate is counted 8-10 part, mussel pearl hydrolyzed solution with Fructus Tritici aestivi and is counted 6-8 part, Oleum Vitis viniferae 1-2 part, Semen Vitis viniferae albumen 3-5 part, Fructus Hippophae extract with mussel pearl and count 6-9 part, bee pollen 0.5-1 part with Fructus Hippophae.
The skin care item that contain above component, can prepare becomes protective skin cream, facial cleaning cream, cream for skin care or surfactant, experimental results show that to use these skin care item after a period of time, the moisture content of skin abundance, elasticity strengthens.
In order to verify beneficial effect of the present invention, zoopery has also been carried out in invention, measures the effect of these skin care item aspect lifting hydroxyproline content and enhance SOD vigor.Hydroxyproline is the abundant and more stable aminoacid of intradermal content, its content can direct reaction intradermal collagen protein content, and collagen protein is the important component in the dermis of skin, its content with advancing age and obviously descends, and collagen content changes the degree that can point out skin aging; SOD is considered to effective anti-oxidants and free radical scavenger in the body, reducing the generation of free radical and removing aging metabolite raising activities of antioxidant enzymes is the effective ways of present delaying decrepitude of skin, the power of oxidation resistance and defying age ability in the big mere suggestion body of SOD vigor.Experimental results show that skin care item of the present invention are applied in old rats skin, can improve the hydroxyproline content and the SOD vigor of rat skin.
Clinical trial has also been carried out in invention, and the experimenter who finds 45-55 year is after using these skin care item, and the skin elasticity value has obtained good improvement, and has persistent improvement effect.
Compared with prior art, the present invention has following beneficial effect:
1. in the skin care item that invention is provided, Fructus Tritici aestivi hydrolysate, mussel pearl hydrolyzed solution, Semen Vitis viniferae albumen etc. not only provide several amino acids and trace element, and organic existence of various nutritional labelings has promoted the absorption of skin, promote that collagen is proteic synthetic in the body, regulate the cellular metabolism function, cell activity enhancing promotes cell viability new life.
2. skin care item of the present invention can also effectively keep and the moisture of additional skin corium, help slow down aging.
3. the effective skin expansion blood vessel of skin care item of the present invention, make SkBF vigorous, and can activate the skin enzyme system, and make the Skin Cell increased activity, improve the metabolism of Skin Cell living environment and promotion skin histology, discharge the skin toxin, make skin elasticity, gloss obviously improves, and can stop unsaturated fatty acids acid oxidase, decomposition in the cells in vivo simultaneously, delaying decrepitude of skin, the elasticity vigor of maintenance skin.Experimental results show that skin care item of the present invention can strengthen skin elasticity effectively, delaying skin is aging.
The specific embodiment
Below further specify technical scheme of the present invention by specific embodiment.
Embodiment 1 emollient cream
The preparation of Fructus Tritici aestivi hydrolysate:
With after 8 parts of Fructus Tritici aestivi defats as substrate, add papain and water, carry out enzyme digestion reaction, reconcentration or dry and get; Wherein the concentration of substrate is mass fraction 6; Enzyme concentration 2000U/g; 55 ℃ of hydrolysis temperatures; Enzymolysis time is 40min.
The preparation of mussel pearl hydrolyzed solution:
Get 6 parts of fresh water pearl powders, add 20 parts of water, add 0.4 part of trypsin, after 45 ℃ of following hydrolysis, filter and get.
The preparation of Fructus Hippophae extract:
After getting 6 parts of sea buckthorn fruits pulverizing, add 18 parts of ethanol waters (alcoholic acid mass fraction is 60%) and extract (microwave extraction 5 minutes), extracting solution obtains Fructus Hippophae extract through vacuum concentration (45 ℃ of temperature).
The preparation of protective skin cream:
List of ingredients (parts by weight)
A. above-mentioned Fructus Tritici aestivi hydrolysate, mussel pearl hydrolyzed solution and Fructus Hippophae extract are mixed, add 1 part of Oleum Vitis viniferae, 3 parts of Semen Vitis viniferae albumen, 0.6 part of bee pollen, as component A.
B. 2 parts of Arlacel-60s, 0.1 part of imidazolidinyl urea, 1 part of Tween-60
C. the purified cotton seed oil is 7 parts
D. essence is 0.4 part
E. to be supplemented to whole component total amounts be 100 parts for 2 parts of octadecanol, (70%) 3 part of sorbitol solution, deionized water.
Preparation: general, C, E component mix respectively and be heated with stirring to 60 ℃, places emulsator fully emulsified B, C, E component, adds A, D component when temperature is reduced to 40 ℃, static 24h.
Embodiment 2 facial cleaning cream
The preparation of Fructus Tritici aestivi hydrolysate:
With after 8 parts of Fructus Tritici aestivi defats as substrate, add papain and water, carry out enzyme digestion reaction, reconcentration or dry and get; Wherein the concentration of substrate is mass fraction 6; Enzyme concentration 2000U/g; 55 ℃ of hydrolysis temperatures; Enzymolysis time is 40min.
The preparation of mussel pearl hydrolyzed solution:
Get 7 parts of fresh water pearl powders, add 20 parts of water, add 0.6 part of trypsin, after 45 ℃ of following hydrolysis, filter and get.
The preparation of Fructus Hippophae extract:
After getting 8 parts of sea buckthorn fruits pulverizing, add 24 parts of ethanol waters (alcoholic acid mass fraction is 80%) and extract (microwave extraction 6 minutes), extracting solution obtains Fructus Hippophae extract through vacuum concentration (45 ℃ of temperature).
The preparation of facial cleaning cream:
List of ingredients (parts by weight)
A. above-mentioned Fructus Tritici aestivi hydrolysate, mussel pearl hydrolyzed solution and Fructus Hippophae extract are mixed, add 2 parts of Oleum Vitis viniferaes, 4 parts of Semen Vitis viniferae albumen, 1 part of bee pollen, as component A.
B. 2 parts of octadecanol, 3 parts of squalanes, 1 part of self-emulsifying type glycerol monostearate.
It is 100 parts that 20 parts of C.C9-10 alkyl poly glucosides, deionization are supplemented to whole component total amounts.
Preparation: B and C component are heated to 75 ℃ respectively, mix homogenizing.Stirring is cooled to 45 ℃, adds the A component, homogenizing.Cool to room temperature.
Embodiment 3 skin creams
The preparation of the mixed extract of Fructus Perillae Frutescentis and Fructus Piperis such as embodiment 2.
The preparation of skin cream:
List of ingredients (parts by weight)
A. above-mentioned Fructus Tritici aestivi hydrolysate, mussel pearl hydrolyzed solution and Fructus Hippophae extract are mixed, add 2 parts of Oleum Vitis viniferaes, 5 parts of Semen Vitis viniferae albumen, 0.5 part of bee pollen, as component A.
B. 0.2 part in essence, 3 parts of hexadecanol, 0.5 part of phenethanol resorcinol.
C. to be supplemented to whole component total amounts be 100 parts for 4 parts of lanolines, 3 parts of glyceryl monostearates, 2.5 parts of glycerol, 2 parts of isopropyl myristates, 1 part of triethanolamine, 2 parts of stearic acid, 0.2 part of methyl hydroxybenzoate, deionization.
Preparation: C is heated to 75 ℃ makes its dissolving, carry out emulsifying, when temperature is reduced to 45 ℃, add A, B, mixing.
Embodiment 4 surfactant
The preparation of Fructus Tritici aestivi hydrolysate:
With after 10 parts of Fructus Tritici aestivi defats as substrate, add papain and water, carry out enzyme digestion reaction, reconcentration or dry and get; Wherein the concentration of substrate is mass fraction 9%; Enzyme concentration 3000U/g; 55 ℃ of hydrolysis temperatures; Enzymolysis time is 40min.
The preparation of mussel pearl hydrolyzed solution:
Get 8 parts of fresh water pearl powders, add 25 parts of water, add 0.6 part of trypsin, after 48 ℃ of following hydrolysis, filter and get.
The preparation of Fructus Hippophae extract:
After getting 9 parts of sea buckthorn fruits pulverizing, add 27 parts of ethanol waters (alcoholic acid mass fraction is 60%) and extract (microwave extraction 6 minutes), extracting solution obtains Fructus Hippophae extract through vacuum concentration (45 ℃ of temperature).
The preparation of surfactant:
List of ingredients (parts by weight)
A. above-mentioned Fructus Tritici aestivi hydrolysate, mussel pearl hydrolyzed solution and Fructus Hippophae extract are mixed, add 1 part of Oleum Vitis viniferae, 4 parts of Semen Vitis viniferae albumen, 0.8 part of bee pollen, as component A.
B. to be supplemented to whole component total amounts be 100 parts for stearic acid 3%, emulsifying agent 3%, deionization.
Preparation: with B component even matter under 75 ℃, be cooled to 50 ℃ and add the A components, stir.
Embodiment 5 common emollient cream
The preparation of common emollient cream:
Lack the component A in batching, other are with embodiment 1.
Embodiment 6 common surfactant
The preparation of common moisture retention water:
Lack the component A in batching, other are with embodiment 4.
Embodiment 7 animal experiments
Get 12 of 22 months old rats, shave off the back by hair with shaver, expose the skin of the about 2cm * 3cm of size, be exposed to naturally in the environment, divide 2 groups to carry out parallel test: test group is smeared the protective skin cream of embodiment 1, and matched group is smeared the common protective skin cream of embodiment 5; All smear once every day.Continue to detect rat skin hydroxyproline content and SOD vigor respectively after 30 days.
1. the mensuration of skin hydroxyproline content: after rat test position skin removes connective tissue, acetone: ether (1: 1=v: v) defat, 80 ℃ of oven dry, the meticulous 50mg that takes by weighing adds 6mol/L HCl 2ml hydrolysis 36h in 80 ℃ of baking boxs; Get hydrolyzed solution 014ml and regulate its pH value 6～7, be settled to 10ml with 6mol/L NaOH liquid; Get this liquid 012ml and go into test tube, add buffer 1ml successively, toluene-sodium-sulfonchloramide 1ml, perchloric acid 1ml, developer 1ml, mixing, 60 ℃ of water-bath 15min 550nm wavelength 1cm optical path colorimetrics, blank zeroing, hydroxyproline content is represented with μ g/mg.
2. total SOD vitality test builds up the SOD of bio-engineering corporation test kit description method with reference to Nanjing and measures the SOD vigor in the skin, and unit represents with U/mg albumen.
Skin hydroxyproline content and SOD vigor testing result are as shown in table 1.By the result as can be known, rat skin is exposed in the air, this can aggravate the aging of skin to a certain extent; And use protective skin cream of the present invention to be used to protect rat skin; can be so that its skin be kept higher vigor; skin hydroxyproline content and SOD vigor all have significantly lifting; pointed out to change metabolism and the new life that skin care item promote rat skin, promoted proteic content of collagen and oxidation resistance in the dermis of skin.
Two kinds of emollient cream of table 1 are to the influence of rat skin THP content and SOD vigor
A, b represent between group significant difference (P＜0.05) is arranged
Embodiment 8
The clinical evaluation test:
The skin protection test:
With the surfactant of embodiment 4 as test group, the common surfactant of embodiment 6 is organized in contrast, adopt Callegari Soft5.5, test 120 45-55 year women triers, experimenter's keratodermatitis moisture and skin elasticity value before record uses earlier, begin afterwards to be coated with continuously and use experimental solutions at specific part, be coated with the position is the skin of the inboard 3.0*3.0cm area of upper arm, respectively choose three place's skins, fixedly smear the surfactant (test group) of embodiment 4 respectively, the common surfactant (matched group) of embodiment 6, any skin care item are not smeared at another place, every day sooner or later respectively once, be coated with continuously with after 24 weeks, test is coated with keratodermatitis moisture and skin elasticity value in the area respectively, contrasted with trying previous crops, estimate the effective percentage of 120 tester's moisture content of skin liftings and the effective percentage that skin elasticity is improved, the result is shown in table 2 and table 3.
Table 2. is coated with the effective percentage with the back experimenter's moisture content of skin lifting of 16 weeks continuously
| Group | Effective percentage (%) |
| Test group | 100％? |
| Matched group | 41.7％? |
| Blank group | 0％? |
Table 3. is coated with the effective percentage with the back experimenter's skin elasticity improvement of 16 weeks continuously
| Group | Effective percentage (%) |
| Test group | 100％? |
| Matched group | 10.8％? |
| Blank group | -6.7％? |
By the result of table 2 and table 3 as can be known, the surfactant of comparing embodiment 6 with common surfactant improves skin moisture content and elastic effectiveness apparently higher than common surfactant, especially improving aspect the skin elasticity, the experimenter of blank group may be owing to reasons such as environmental effect and natural agings, there is 6.7% experimenter the phenomenon that the skin elasticity value obviously reduces to occur, and the improvement effect of matched group (common surfactant) is limited, only 10.8% experimenter tests out the skin elasticity value and has clear improvement, and the effective percentage of test group (embodiment 4 surfactant) reaches 100%, be significantly higher than matched group, have the incomparable effect of common surfactant aspect the skin elasticity improving.Perusal uses the position skin of embodiment 4 surfactant more to compact.
Claims (10)
1.BASILCON refreshing bright water vegetable active essence skin care item is characterized in that comprising following component: Fructus Tritici aestivi hydrolysate, mussel pearl hydrolyzed solution, Oleum Vitis viniferae, Semen Vitis viniferae albumen, Fructus Hippophae extract, bee pollen.
2. skin care item as claimed in claim 1 is characterized in that described Fructus Tritici aestivi hydrolysate is to be obtained by following method: with after the Fructus Tritici aestivi defat as substrate, add papain and water, carry out enzyme digestion reaction, reconcentration or dry and get.
3. skin care item as claimed in claim 2 is characterized in that in the described enzyme digestion reaction that the concentration of substrate is mass fraction 6%-9%; Enzyme concentration 2000-3000U/g; 55 ℃ of hydrolysis temperatures; Enzymolysis time is 40-50min.
4. skin care item as claimed in claim 1 is characterized in that described mussel pearl hydrolyzed solution is to make by the following method: get 30～35 parts of fresh water pearl powders, add 100 parts of water, add 2～3 parts of trypsin hydrolyzing after-filtration and get.
5. skin care item as claimed in claim 4 is characterized in that described hydrolysis temperature is 45-48 ℃.
6. skin care item as claimed in claim 1 is characterized in that described Fructus Hippophae extract is after sea buckthorn fruit is pulverized, to add ethanol water and extract, and extracting solution concentrates and obtains.
7. skin care item as claimed in claim 6 is characterized in that alcoholic acid mass fraction is 60-90% in the described ethanol water; The ethanol water that the Fructus Hippophae of every 1-2 part weight adds 3-6 part weight extracts.
8. skin care item as claimed in claim 6 is characterized in that described extraction is to adopt microwave extraction 4-8 minute.
9. skin care item as claimed in claim 1 is characterized in that described composition weight proportioning constitutes: the Fructus Tritici aestivi hydrolysate is counted 8-10 part, mussel pearl hydrolyzed solution with Fructus Tritici aestivi and is counted 6-8 part, Oleum Vitis viniferae 1-2 part, Semen Vitis viniferae albumen 3-5 part, Fructus Hippophae extract with mussel pearl and count 6-9 part, bee pollen 0.5-1 part with Fructus Hippophae.
10. skin care item as claimed in claim 1 is characterized in that described skin care item are protective skin cream, facial cleaning cream, cream for skin care or surfactant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105126239A CN102018650B (en) | 2010-10-19 | 2010-10-19 | Plant active essence |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105126239A CN102018650B (en) | 2010-10-19 | 2010-10-19 | Plant active essence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102018650A true CN102018650A (en) | 2011-04-20 |
| CN102018650B CN102018650B (en) | 2012-06-13 |
Family
ID=43860705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105126239A Active CN102018650B (en) | 2010-10-19 | 2010-10-19 | Plant active essence |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102018650B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456165A (en) * | 2015-12-19 | 2016-04-06 | 青岛浩大海洋保健食品有限公司 | Anti-skin-aging, beauty, skin care and whitening puffer fish skin health care lotion |
| CN108245454A (en) * | 2018-02-26 | 2018-07-06 | 广州丽丰化妆品制造有限公司 | A kind of rich results hydrating cleanser containing natural anti-oxidation ingredient and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101278994A (en) * | 2007-04-06 | 2008-10-08 | 王洪飞 | Prinsepia utilis Royle oral nursing soft capsules |
| CN101444273A (en) * | 2007-11-22 | 2009-06-03 | 何煜 | Health product oral fast-release preparation and production method thereof |
-
2010
- 2010-10-19 CN CN2010105126239A patent/CN102018650B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101278994A (en) * | 2007-04-06 | 2008-10-08 | 王洪飞 | Prinsepia utilis Royle oral nursing soft capsules |
| CN101444273A (en) * | 2007-11-22 | 2009-06-03 | 何煜 | Health product oral fast-release preparation and production method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456165A (en) * | 2015-12-19 | 2016-04-06 | 青岛浩大海洋保健食品有限公司 | Anti-skin-aging, beauty, skin care and whitening puffer fish skin health care lotion |
| CN108245454A (en) * | 2018-02-26 | 2018-07-06 | 广州丽丰化妆品制造有限公司 | A kind of rich results hydrating cleanser containing natural anti-oxidation ingredient and preparation method thereof |
| CN108245454B (en) * | 2018-02-26 | 2020-12-04 | 广州丽丰化妆品制造有限公司 | Mild cleansing cream containing natural antioxidant components and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102018650B (en) | 2012-06-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102018651B (en) | Aloe extract | |
| EP2355782A2 (en) | A complex of active vegetal stem cells and a cosmetic composition | |
| CN110025528A (en) | A kind of anti-oxidant cleawhite over-night essences and preparation method thereof without deionized water | |
| CN110731974A (en) | Skin external composition with enhanced anti-inflammatory efficacy | |
| CN101322677B (en) | Complexes of hydrolytic collagen protein and avenin and uses thereof | |
| CN106176275A (en) | A kind of skin care item based on telomerase delaying skin aging disease | |
| CN110215423A (en) | The anti-ageing composition of reparation containing various plants extract, preparation method and application | |
| CN112043621A (en) | Preservative-free polypeptide composition with anti-aging effect | |
| CN108066215A (en) | A kind of composition of whitening and anti-aging, the skin care item and preparation method for including it | |
| CN102018650B (en) | Plant active essence | |
| CN102018652B (en) | Binary moisturizing system | |
| JP2023171950A (en) | Anti-aging agent, antioxidant, anti-inflammatory agent, and whitening agent, as well as cosmetic | |
| CN102949328B (en) | Toning lotion with functions of anti-senile, wrinkle-dispelling and moisturizing and preparation method thereof | |
| CN109481344B (en) | Plant polysaccharide composition and application thereof | |
| Marimuthu et al. | Application and merits of Eggshell Membrane in Cosmetics | |
| CN107174536A (en) | A kind of salamander face beautifying skin protection product and preparation method thereof | |
| CN109998941A (en) | Anti-apolexis composition, anti-ageing face mask and preparation method thereof | |
| CN114805485A (en) | Chlorella bioactive peptide and application thereof in preparation of anti-aging essence | |
| KR20150058635A (en) | Composition containing fermentated opuntia humifusa showing biological activity of skin | |
| CN112190516A (en) | Preparation method of plateau barley fermentation liquor | |
| KR102002891B1 (en) | Cosmetic compositions comprising extracts of daedaleopsis tricolor and fermentation material by mycelium of daedaleopsis tricolor | |
| KR20090068397A (en) | Cosmetic composition with the effect of calming skins | |
| CN107320360A (en) | One kind repairs damage hydrating mist | |
| JP7497974B2 (en) | Method for activating skin stem cells by suppressing MPC1 and skin stem cell activator | |
| WO2021125346A1 (en) | Method for activating skin stem cells through mpc1 suppression, and skin stem cell activation agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |