CN105456165A - Anti-skin-aging, beauty, skin care and whitening puffer fish skin health care lotion - Google Patents

Abstract

The invention discloses anti-skin-aging, beauty, skin care and whitening puffer fish skin health care lotion. According to the anti-skin-aging, beauty, skin care and whitening puffer fish skin health care lotion, puffer fish skin, astragalus membranaceus, radix ophiopogonis, angelica dahurica, ligusticum wallichii, liquorice, root of kudzu vine, dendrobium nobile, polygonum multiflorum, tuckahoe, bighead atractylodes rhizome and schisandra chinensis are selected as raw materials, the leaching efficiency of active ingredients of Chinese herbal medicine is improved through the technology of ultrasonic assisted extraction, microbial fermentation and ultrasonic assisted ethanol extraction, and the content of superoxide dismutase in the lotion is improved through the fermentation of bifidobacterium bifidum. Beauty and skin care substances, such as catechinic acid, rose essential oil, seaweed polysaccharide, hyaluronic acid and vitamin C are compounded, the anti-skin-aging, beauty, skin care and whitening effect of the lotion is further improved, and the anti-skin-aging, beauty, skin care and whitening puffer fish skin health care lotion has good application effect and market popularizing prospect.

Description

The globefish skin health-care and skin-care water of a kind of anti aging effect beauty care whitening

Technical field

The present invention relates to globefish skin health-care and skin-care water and the preparation method of the whitening of a kind of anti aging effect beauty care, belong to health and beauty product scope.

Background technology

Globe fish ( fugurubripes) in containing extremely toxic substance tetrodotoxin, this toxin has high economic worth and medical value.People comparatively go deep into %, careful to the research of tetrodotoxin, but have ignored the value of globe fish other side.Along with non-toxic globefish cultivation and the development of processing detoxification technology, the output of China's non-toxic globefish rises year by year, year outlet rate more than 90%, has now become the main source of external globe fish supply.The export processing of globe fish creates the leftover bits and pieces such as a large amount of fish skin, causes significant wastage and the environmental pollution of resource.Containing a large amount of collagen protein in globefish skin, about 88.5%, extract the quality raw materials preparing gelatin, collagen peptide, collagen peptide has many important physiological functions, as suppressed ACE, promoting skin collagen metabolism, antioxidation, increase bone density etc., the fields such as medicine, cosmetics, health product can be widely used in.

Aging is that each organ of body engenders the progressive process that hypofunction and reserve capabillity decline along with the continuous increase at age.Skin is the maximum organ of human body, has the effects such as sensation, protection, absorption, metabolism, immunity, secretion, excretion, regulate body temperature.With advancing age, skin also can as other organs of human body miopragia, produce various pathological changes, little by little enter ageing state.The aging of skin is that whole body aging is the most external, the most significantly performance.Therefore prevention and delay skin aging have become current social medical research focus.

Naturally aging of skin is with advancing age and betides the degenerative change of skin texture and physiological function.Chinese medicine is thought: the main cause of skin aging is deficient five internal organs, disorder of QI and blood etc., and by nourishing the five internal organs, QI and blood regulating is the important means of traditional Chinese medical science delay skin aging.The research of Chinese medicine in anti aging effect has the advantage of rich experience and uniqueness.Along with the progressively raising of people's lives, the health care consciousness of people strengthens gradually, and the demand in anti aging effect, skin protection whitening etc. increases day by day, Chinese herbal medicine in this field health promoting product development process in occupation of innate advantage condition.For passing on Chinese medicinal herb culture of long standing and well established, meet the demand of women to anti aging effect skin-protecting face nursing Skin whitening care cosmetics, the present invention chooses the Chinese herbal medicine with effects such as QI invigorating tonification, strengthening the body resistance, develops the herbal health care surfactant with anti aging effect skin-protecting face nursing white-skinned face function.

Summary of the invention

The object of the present invention is to provide the globefish skin health-care and skin-care water of a kind of anti aging effect beauty care whitening.

For achieving the above object, the technical solution used in the present invention is as follows:

The invention provides the globefish skin health-care and skin-care water of a kind of anti aging effect beauty care whitening, it is characterized in that the raw material selected and proportion compatibility thereof are: globefish skin 20 ~ 30 parts, the Radix Astragali 5 ~ 10 parts, Radix Ophiopogonis 6 ~ 8 parts, the Radix Angelicae Dahuricae 4 ~ 6 parts, Rhizoma Chuanxiong 8 ~ 12 parts, 5 ~ 10 parts, Radix Glycyrrhizae, Radix Puerariae 3 ~ 5 parts, Herba Dendrobii 3 ~ 5 parts, Radix Polygoni Multiflori 5 ~ 8 parts, 4 ~ 6 parts, Poria, the Rhizoma Atractylodis Macrocephalae 8 ~ 10 parts, Fructus Schisandrae Chinensis 4 ~ 6 parts.

The invention provides the globefish skin health-care and skin-care water of a kind of anti aging effect beauty care whitening, it is characterized in that preparation technology specifically comprises the following steps:

(1) material combination: Chinese herbal medicine is sorted, remove and rot and moth person, cleaning is dried, according to the above ratio compatibility Chinese herbal medicine;

(2) pulverize: pulverize after Chinese herbal medicine mixing, cross 100 mesh sieves;

(3) Ultrasonic Wave-Assisted Extraction: be dissolved in by Chinese herbal medicine in 8 ~ 10 times of deionized waters, adds 1 ~ 2% α-amylase, 2 ~ 3% non-starch polysaccharide enzymes, 1 ~ 2% saccharifying enzyme, under 300W ultrasonic assistant condition, and lixiviate 40 ~ 60min, control temperature 40 ~ 60 DEG C;

(4) fermentable: add the bifidobacterium bifidum after 3 ~ 5% activation in lixiviating solution, anaerobic condition bottom fermentation 6 ~ 10h, control fermentation temperature 28 ~ 35 DEG C;

(5) centrifugal: centrifugalize solid residue and supernatant after fermentation ends;

(6) ultrasonic assistant alcohol steep: adding 2 ~ 3 times of concentration in solid residue is the ethanol of 70%, lixiviate 20 ~ 30min under ultrasonic assistant condition, extraction temperature 40 ~ 60 DEG C;

(7) centrifugal: lixiviate terminates rear centrifugalize solid residue and alcohol extract;

(8) concentrated distillation: alcohol extract is concentrated Distillation recovery ethanol;

(9) mix: the alcohol extract after reclaiming ethanol is mixed with fermented supernatant fluid;

(10) composite: in mixed skin care liquid, to add 0.02 ~ 0.03% catechin, 0.3 ~ 0.5% Flos Rosae Rugosae quintessence oil, 1 ~ 2% Sargassum polysaccharides, 0.05 ~ 0.1% hyaluronic acid, 1 ~ 2% vitamin C, 0.5 ~ 1% glycerol, adjustment pH6.0 ~ 7.0;

(11) homogenizing: namely homogenizing obtains the herbal health care surfactant of anti aging effect beauty care whitening on homogenizer.

The invention provides the globefish skin health-care and skin-care water of a kind of anti aging effect beauty care whitening, with product of the present invention, safety evaluatio has been carried out to SD rat skin acute toxicity, new zealand rabbit skin irritation and guinea pig skin allergy.Experimental result shows, and product of the present invention, to intact skin non-toxic reaction, has no stimulation to intact skin, to guinea pig skin allergy without obvious effect, proves this product safety avirulence.

The invention provides the globefish skin health-care and skin-care water of a kind of anti aging effect beauty care whitening, it is advantageous that: one is the Chinese herbal medicine such as scientific compatibility globefish skin, the Radix Astragali, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Glycyrrhizae, Radix Puerariae, Herba Dendrobii, Radix Polygoni Multiflori, Poria, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, by the synergism between Chinese herbal medicine, play effect of anti aging effect beauty care whitening; Two is that the present invention passes through " Ultrasonic Wave-Assisted Extraction+fermentable+ultrasonic assistant alcohol extraction " technique, not only increase the leaching rate of Chinese herbal medicine active component, in Chinese herbal medicine, Saponin, flavone, alkaloidal extraction ratio are all more than 95%, and particularly globefish skin albumen is fully hydrolyzed to polypeptide; In addition, the content of superoxide dismutase in skin care liquid is improve by the fermentation of bifidobacterium bifidum; Three is the composite materials such as catechin, Flos Rosae Rugosae quintessence oil, Sargassum polysaccharides, hyaluronic acid, vitamin C with beauty care effect of the present invention, further increases the anti-aging nursing face skin protection white-skinned face function of skin care liquid, has good marketing prospect.

Different Chinese herbal medicine nature and flavor are different, effect also exists huge difference, complicated interaction relationship is there is after different Chinese herbal medicine combinations, and proportioning between Chinese herbal medicine is closer, different ratio also will make monarch relation that substantial change occurs, thus make the relation generation material alterations of composite Chinese herbal.Complicated interaction relationship is there is to each other in the application by Chinese herbal medicine such as globefish skin, the Radix Astragali, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Glycyrrhizae, Radix Puerariae, Herba Dendrobii, Radix Polygoni Multiflori, Poria, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, pass through rational proportion, make the relation generation material alterations of skin care liquid, testing result shows that the total antioxidant capacity of skin care liquid of the present invention is 345.32 ± 16.25U/mL, is significantly higher than level of having reported for work at present.The anti aging effect effect of product of the present invention is verified with mouse animal experiment, mice skin tissue superoxide dismutase (SOD) after the different skin care liquid of mensuration use, glutathion peroxidase (GSH-Px), the indexs such as malonaldehyde (MDA) and hydroxyproline (Hyp), experimental result shows that SOD value is 25.11 ± 3.58, GSH-Px value is 52.31 ± 7.25, MDA value is 0.97 ± 0.12, Hyp value is 2.69 ± 0.30, show that skin care liquid of the present invention has good anti aging effect effect, with blank group difference extremely remarkable (p<0.01), experimental result also shows to change the composition of Chinese herbal medicine or the anti aging effect effect of reduction product more remarkable in regular meeting.

Detailed description of the invention

embodiment 1:

A globefish skin health-care and skin-care water for anti aging effect beauty care whitening, concrete preparation process is as follows:

(1) material combination: Chinese herbal medicine is sorted, remove and rot and moth person, cleaning is dried, in globefish skin 25 parts, the Radix Astragali 8 parts, Radix Ophiopogonis 7 parts, the Radix Angelicae Dahuricae 5 parts, Rhizoma Chuanxiong 10 parts, 8 parts, Radix Glycyrrhizae, Radix Puerariae 4 parts, Herba Dendrobii 4 parts, Radix Polygoni Multiflori 7 parts, 5 parts, Poria, the Rhizoma Atractylodis Macrocephalae 9 parts, Fructus Schisandrae Chinensis 5 parts of ratio compatibility Chinese herbal medicine;

(2) pulverize: pulverize after Chinese herbal medicine mixing, cross 100 mesh sieves;

(3) Ultrasonic Wave-Assisted Extraction: be dissolved in by Chinese herbal medicine in 10 times of deionized waters, adds 2% α-amylase, 3% non-starch polysaccharide enzyme, 2% saccharifying enzyme, under 300W ultrasonic assistant condition, and lixiviate 40min, control temperature 40 ~ 60 DEG C;

(4) fermentable: add the bifidobacterium bifidum after 5% activation in lixiviating solution, anaerobic condition bottom fermentation 6h, controls fermentation temperature 28 ~ 35 DEG C;

(5) centrifugal: centrifugalize solid residue and supernatant after fermentation ends;

(6) ultrasonic assistant alcohol steep: adding 3 times of concentration in solid residue is the ethanol of 70%, lixiviate 20min under ultrasonic assistant condition, extraction temperature 40 ~ 60 DEG C;

(7) centrifugal: lixiviate terminates rear centrifugalize solid residue and alcohol extract;

(8) concentrated distillation: alcohol extract is concentrated Distillation recovery ethanol;

(9) mix: the alcohol extract after reclaiming ethanol is mixed with fermented supernatant fluid;

(10) composite: in mixed skin care liquid, to add 0.03% catechin, 0.5% Flos Rosae Rugosae quintessence oil, 2% Sargassum polysaccharides, 0.1% hyaluronic acid, 2% vitamin C, 1% glycerol, adjustment pH6.0 ~ 7.0;

(11) homogenizing: namely homogenizing obtains the herbal health care surfactant of anti aging effect beauty care whitening on homogenizer.

embodiment 2:

A globefish skin health-care and skin-care water for anti aging effect beauty care whitening, concrete preparation process is as follows:

(1) material combination: Chinese herbal medicine is sorted, remove and rot and moth person, cleaning is dried, in globefish skin 30 parts, the Radix Astragali 5 parts, Radix Ophiopogonis 8 parts, the Radix Angelicae Dahuricae 4 parts, Rhizoma Chuanxiong 12 parts, 5 parts, Radix Glycyrrhizae, Radix Puerariae 5 parts, Herba Dendrobii 3 parts, Radix Polygoni Multiflori 8 parts, 4 parts, Poria, the Rhizoma Atractylodis Macrocephalae 10 parts, Fructus Schisandrae Chinensis 4 parts of ratio compatibility Chinese herbal medicine;

(2) pulverize: pulverize after Chinese herbal medicine mixing, cross 100 mesh sieves;

(3) Ultrasonic Wave-Assisted Extraction: be dissolved in by Chinese herbal medicine in 9 times of deionized waters, adds 1.5% α-amylase, 2.5% non-starch polysaccharide enzyme, 1.5% saccharifying enzyme, under 300W ultrasonic assistant condition, and lixiviate 50min, control temperature 40 ~ 60 DEG C;

(4) fermentable: add the bifidobacterium bifidum after 4% activation in lixiviating solution, anaerobic condition bottom fermentation 8h, controls fermentation temperature 28 ~ 35 DEG C;

(5) centrifugal: centrifugalize solid residue and supernatant after fermentation ends;

(6) ultrasonic assistant alcohol steep: adding 2.5 times of concentration in solid residue is the ethanol of 70%, lixiviate 25min under ultrasonic assistant condition, extraction temperature 40 ~ 60 DEG C;

(7) centrifugal: lixiviate terminates rear centrifugalize solid residue and alcohol extract;

(8) concentrated distillation: alcohol extract is concentrated Distillation recovery ethanol;

(9) mix: the alcohol extract after reclaiming ethanol is mixed with fermented supernatant fluid;

(10) composite: in mixed skin care liquid, to add 0.025% catechin, 0.4% Flos Rosae Rugosae quintessence oil, 1.5% Sargassum polysaccharides, 0.08% hyaluronic acid, 1.5% vitamin C, 0.8% glycerol, adjustment pH6.0 ~ 7.0;

(11) homogenizing: namely homogenizing obtains the herbal health care surfactant of anti aging effect beauty care whitening on homogenizer.

embodiment 3:

A globefish skin health-care and skin-care water for anti aging effect beauty care whitening, concrete preparation process is as follows:

(1) material combination: Chinese herbal medicine is sorted, remove and rot and moth person, cleaning is dried, in globefish skin 20 parts, the Radix Astragali 10 parts, Radix Ophiopogonis 6 parts, the Radix Angelicae Dahuricae 6 parts, Rhizoma Chuanxiong 8 parts, 10 parts, Radix Glycyrrhizae, Radix Puerariae 3 parts, Herba Dendrobii 5 parts, Radix Polygoni Multiflori 5 parts, 6 parts, Poria, the Rhizoma Atractylodis Macrocephalae 8 parts, Fructus Schisandrae Chinensis 6 parts of ratio compatibility Chinese herbal medicine;

(2) pulverize: pulverize after Chinese herbal medicine mixing, cross 100 mesh sieves;

(3) Ultrasonic Wave-Assisted Extraction: be dissolved in by Chinese herbal medicine in 8 times of deionized waters, adds 1% α-amylase, 2% non-starch polysaccharide enzyme, 1% saccharifying enzyme, under 300W ultrasonic assistant condition, and lixiviate 60min, control temperature 40 ~ 60 DEG C;

(4) fermentable: add the bifidobacterium bifidum after 3% activation in lixiviating solution, anaerobic condition bottom fermentation 10h, controls fermentation temperature 28 ~ 35 DEG C;

(5) centrifugal: centrifugalize solid residue and supernatant after fermentation ends;

(6) ultrasonic assistant alcohol steep: adding 2 times of concentration in solid residue is the ethanol of 70%, lixiviate 30min under ultrasonic assistant condition, extraction temperature 40 ~ 60 DEG C;

(7) centrifugal: lixiviate terminates rear centrifugalize solid residue and alcohol extract;

(8) concentrated distillation: alcohol extract is concentrated Distillation recovery ethanol;

(9) mix: the alcohol extract after reclaiming ethanol is mixed with fermented supernatant fluid;

(10) composite: in mixed skin care liquid, to add 0.02% catechin, 0.3% Flos Rosae Rugosae quintessence oil, 1% Sargassum polysaccharides, 0.05% hyaluronic acid, 1% vitamin C, 0.5% glycerol, adjustment pH6.0 ~ 7.0;

(11) homogenizing: namely homogenizing obtains the herbal health care surfactant of anti aging effect beauty care whitening on homogenizer.

Above embodiment only for illustration of technical scheme of the present invention, but not is limited; Although be described in detail by invention with reference to previous embodiment, for the person of ordinary skill of the art, still the technical scheme described in previous embodiment can be modified, or equivalent replacement has been carried out to wherein portion of techniques feature; And to these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.

Claims (1)

1. a globefish skin health-care and skin-care water for anti aging effect beauty care whitening, is characterized in that concrete preparation process is as follows:

(1) material combination: Chinese herbal medicine is sorted, remove and rot and moth person, cleaning is dried, in globefish skin 20 ~ 30 parts, the Radix Astragali 5 ~ 10 parts, Radix Ophiopogonis 6 ~ 8 parts, the Radix Angelicae Dahuricae 4 ~ 6 parts, Rhizoma Chuanxiong 8 ~ 12 parts, 5 ~ 10 parts, Radix Glycyrrhizae, Radix Puerariae 3 ~ 5 parts, Herba Dendrobii 3 ~ 5 parts, Radix Polygoni Multiflori 5 ~ 8 parts, 4 ~ 6 parts, Poria, the Rhizoma Atractylodis Macrocephalae 8 ~ 10 parts, Fructus Schisandrae Chinensis 4 ~ 6 parts of ratio compatibility Chinese herbal medicine;

(2) pulverize: pulverize after Chinese herbal medicine mixing, cross 100 mesh sieves;

(3) Ultrasonic Wave-Assisted Extraction: be dissolved in by Chinese herbal medicine in 8 ~ 10 times of deionized waters, adds 1 ~ 2% α-amylase, 2 ~ 3% non-starch polysaccharide enzymes, 1 ~ 2% saccharifying enzyme, under 300W ultrasonic assistant condition, and lixiviate 40 ~ 60min, control temperature 40 ~ 60 DEG C;

(4) fermentable: add the bifidobacterium bifidum after 3 ~ 5% activation in lixiviating solution, anaerobic condition bottom fermentation 6 ~ 10h, control fermentation temperature 28 ~ 35 DEG C;

(5) centrifugal: centrifugalize solid residue and supernatant after fermentation ends;

(6) ultrasonic assistant alcohol steep: adding 2 ~ 3 times of concentration in solid residue is the ethanol of 70%, lixiviate 20 ~ 30min under ultrasonic assistant condition, extraction temperature 40 ~ 60 DEG C;

(7) centrifugal: lixiviate terminates rear centrifugalize solid residue and alcohol extract;

(8) concentrated distillation: alcohol extract is concentrated Distillation recovery ethanol;

(9) mix: the alcohol extract after reclaiming ethanol is mixed with fermented supernatant fluid;

(10) composite: in mixed skin care liquid, to add 0.02 ~ 0.03% catechin, 0.3 ~ 0.5% Flos Rosae Rugosae quintessence oil, 1 ~ 2% Sargassum polysaccharides, 0.05 ~ 0.1% hyaluronic acid, 1 ~ 2% vitamin C, 0.5 ~ 1% glycerol, adjustment pH6.0 ~ 7.0;

(11) homogenizing: namely homogenizing obtains the herbal health care surfactant of anti aging effect beauty care whitening on homogenizer.