CN1212137C - Hair follice activating liquid - Google Patents
Hair follice activating liquid Download PDFInfo
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- CN1212137C CN1212137C CN 02155404 CN02155404A CN1212137C CN 1212137 C CN1212137 C CN 1212137C CN 02155404 CN02155404 CN 02155404 CN 02155404 A CN02155404 A CN 02155404A CN 1212137 C CN1212137 C CN 1212137C
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Abstract
The present invention aims to provide a hair follicle activating liquid for treating alopecia, which has effective action on hair follicles and is better than the existing hair nourishing products. The hair follicle activating liquid of the present invention is characterized in that 0.175 to 0.585 parts by weight of ginseng extract, 0.126 to 0.420 parts by weight of gynostemma P, E, 0.100 to 0.340 parts by weight of liquorice extract, 0.095 to 0.316 parts by weight of sophora flavescens extract and 0.0036 to 0.012 parts by weight of hot pepper extract are weighed to be put into 100 parts by weight of 75% ethanol to be fully stirred and dissolved and then filtered after 12 hours to obtain a liquid product which is brownish red and clear.
Description
Technical field
The present invention relates to extraordinary cosmetic field.More particularly, relate to a kind of hair follicle activation liquid that is used to improve seborrheic alopecia.
Background technology
Alopecia and be born in the male because of alopecia causes bald pilosity is a kind of commonplace phenomenon.Its reason more complicated it is believed that heredity is a key factor, and in addition, androgen is too much, and psychentonia, emotional instability etc. all are considered to the reason of its generation.
Hair is the part of tissue, is pushed to skin surface and grows after hair follicle inner cell division.Therefore nutrition, the metabolism situation of alopecia phenomenon and hair follicle have direct relation.In order to improve alopecia and to promote the growth of hair.The method of external reactive protein with the nourishing hair follicle arranged in the prior art, but effect is not remarkable.In addition, also there are some to spread, but, therefore do not form the product on the real invention meaning because science is backward in the past in proved recipe among the people in China.
The inventor is from nineteen sixty-eight, the research of being devoted to improve alopecia and causing bald special cosmetics because of alopecia.By traditional proved recipe of China and modern science and technology are combined, proposed to improve the 101 HAIR BREEDING AGENT of seborrheic alopecia in 1986 first, and obtained remarkable result.For over ten years, 101 educate and send out a product and formed series and enjoy a good market both at home and abroad, and repeatedly prize-winning in the world.In recent years the 101 hair follicle nourishing liquids of Tui Chuing are conceived to hair follicle is nourished, and as effective ingredient, have further obtained good effect with traditional Chinese herbal medicine Radix Ginseng, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Sophorae Flavescentis etc.
But, an existing product of educating is abundant not enough to the improvement effect of middle and advanced stage seborrheic alopecia, in addition, 101 series are educated a product and were used nearly 20 years, the inventor to the research of alopecia mechanism further deeply, the experience of accumulation is abundanter, these conditions make might propose a kind of than existing educate send out the product better effects if, also have the educating of update of apparent effect to send out a product to the middle and advanced stage seborrheic alopecia.
Summary of the invention
In view of the foregoing, the objective of the invention is to, provide a kind of that can work more effectively to hair follicle, send out the special cosmetics product better effects if, that be specially adapted to improve the middle and advanced stage seborrheic alopecia than existing educating---hair follicle activates liquid.
Another object of the present invention is, provides a kind of above-mentioned hair follicle to activate the using method of liquid.
The inventor is through research with keen determination repeatedly for many years, the result learns: dense hair stems from normal hair follicle hair growth promoting function, when the metabolism of hair does not have obstacle, hair can come off and grow in normal ratio, if the hair growth promoting function generation obstacle of hair follicle, the trophophase of hair will shorten, so the phenomenon of the more and more tiny or unusual alopecia of hair occurs.
The inventor loses nutrition, causes hair to attenuate deliquescing until situation about coming off at middle and advanced stage seborrheic alopecia person hair follicle, effective component extracting from Chinese herbal medicine such as the Radix Ginseng that is of value to generating and nourishing hair, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae, Fructus Capsici, Radix Sophorae Flavescentis, adopt modern crafts to make tincture, through experiment screening repeatedly, finally finished the present invention again.
The present invention is a kind of hair follicle activation liquid that is used to improve alopecia, it is characterized in that, take by weighing Radix Ginseng extract, Herb Gynostemmae Pentaphylli extract, Radix Glycyrrhizae extract, Radix Sophorae Flavescentis extract, Fructus Capsici extract respectively by following proportioning, place 75% the abundant stirring and dissolving of alcoholic solution, place after 12 hours, filtration obtains reddish brown clarifying fluid product
Radix Ginseng extract: 0.175～0.585 parts by weight; Herb Gynostemmae Pentaphylli extract: 0.126～0.420 parts by weight; Radix Glycyrrhizae extract: 0.100～0.340 parts by weight; Radix Sophorae Flavescentis extract: 0.095～0.316 parts by weight; Fructus Capsici extract: 0.0036～0.012 parts by weight; 75% ethanol: 100 parts by weight.
The present invention also provides a kind of above-mentioned hair follicle that is used to improve alopecia to activate the using method of liquid, it is characterized in that every day 1～2 time, each 5ml～8ml is used for scalp, wipes in alopecia place outward, gently rubs to absorb promoting in 5～10 minutes.
Hair follicle of the present invention activates liquid, when using respectively separately above-mentioned each effective ingredient, can not reach desired effects, but after in ethanol, being mixed and made into tincture by said ratio, because the collaborative synergism as the Radix Ginseng extract of effective ingredient, Herb Gynostemmae Pentaphylli extract, Radix Glycyrrhizae extract, Radix Sophorae Flavescentis extract, Fructus Capsici extract just can reach the goal of the invention that the present invention is scheduled to.Experiment screening is definite repeatedly through the inventor for the bound of above-mentioned each constituent content.Wherein the content range of each all can not reach purpose of the present invention less than its lower limit.And go up in limited time greater than described, not only can not reach goal of the invention, but also may produce certain side effect.When for example Fructus Capsici extract surpasses 0.012 parts by weight, can produce stronger stimulation to skin.
Below the present invention will be described in more detail.
The active matter that hair follicle activation liquid of the present invention contains is the necessary material of hair follicle cell growth metabolism.Local topical can directly infiltrate into the hair follicle deep layer, makes hair follicle obtain competent nourishing, suppresses the too much secretion of sebaceous gland simultaneously, improves the oils and fats thromboembolism in the follicular orifice, promotes the scalp blood circulation, increases blood flow, thereby makes hair be able to ramp.
Theory of Chinese medical science thinks, seborrheic alopecia is (Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases order send out long time ") because due to " retention of damp-heat in the interior, diseases caused by exogenous pathogenic factor ailment said due to cold or exposure are accumulate the resistance skin, damp and hot heavy ".And think " hair is the sign of blood condition ", " blood Sheng Zefa profit, blood declines then to send out and declines " (Ming Li stile " Elementary Medicine ").Therefore, the inventor has determined following principle: seborrheic alopecia is treated based on the fat of dispelling, is nourished blood, dispels the wind, dehumidifies.
Activate in the effective ingredient of liquid at hair follicle of the present invention, Fructus Capsici extract adopts supercritical technology, has extracted to have the biological activity that activates the hair follicle effect; The effect that Herb Gynostemmae Pentaphylli extract has the oils and fats of dispelling, controls poliosis, clears up hair follicle rubbish; Radix Sophorae Flavescentis extract has heat clearing away, dehumidifies, dispels the wind, the itching relieving effect; Radix Ginseng extract has replenishing QI to invigorate the spleen, nourishes the effect of hair; The effect of Radix Glycyrrhizae extract tool coordinating the actions of various ingredients in a prescription can show the inhibition cytopathy and take place, and histiocyte is protected.The hair follicle that uses above-mentioned effective ingredient and make as solvent with ethanol activates liquid, local outer the wiping can be enlivened circulation, increase blood flow, it is balanced nutritious that root of hair is obtained, and activates the root of hair hair follicle, the timid hair follicle rubbish that removes, reach the purpose of hair growth promoting, anti-alopecia, hair follicle of the present invention activates liquid and 101 series in past and educates and send out an agent and compare, and effect is showing more, particularly for the middle and advanced stage seborrheic alopecia good effect is arranged.
Below hair follicle of the present invention is activated each active princlple of liquid preparation method describe respectively.
1. Radix Ginseng extract (latin name: Radix ginseng)
Getting clean Radix Ginseng, be ground into coarse powder, put in the Multifunction tank, is extracting solution with 75% ethanol, and hot reflux extracts twice, adds 4 times of amount 75% alcohol heat reflux 2h for the first time, adds 3 times of amount alcohol heat reflux 1.5h for the second time.Merge the backflow after-filtration, filtrate decompression is refluxed ethanol after do not have the alcohol flavor, add the equivalent ether defatting, divide water intaking solution, add the n-butanol extraction secondary, merge butanol extraction liquid, concentrating under reduced pressure reclaims n-butyl alcohol, the concentrated solution drying under reduced pressure, Radix Ginseng extract.
2. Herb Gynostemmae Pentaphylli extract (latin name: Gynostemma pentaphyllum (thunb.) makino)
Getting Herb Gynostemmae Pentaphylli, be ground into coarse powder, put in the Multifunction tank, is extracting solution with 75% ethanol, and hot reflux extracts twice, adds 4 times of amount 75% alcohol heat reflux 2h for the first time, adds 3 times of amount alcohol heat reflux 1.5h for the second time.Merge backflow, filter, filtrate decompression is refluxed ethanol after do not have the alcohol flavor, add the equivalent ether defatting, divide water intaking solution, add the n-butanol extraction secondary, merge butanol extraction liquid, concentrating under reduced pressure reclaims n-butyl alcohol, the concentrated solution drying under reduced pressure, Herb Gynostemmae Pentaphylli extract.
3. Radix Glycyrrhizae extract (latin name: Radix glycyrrhizae)
Get clean Radix Glycyrrhizae, be ground into coarse powder, with weak ammonia fully moistening after, put in the percolation jar, be the solvent percolation with water after reddish brown, dilute sulfuric acid slowly added in the percolate to no longer producing, filter, precipitation is dissolved in a small amount of weak ammonia after, filter, the evaporation drying filtrate gets Radix Glycyrrhizae extract.
4. (latin name: Radix sophorae flavescentis) get clean Radix Sophorae Flavescentis, be ground into coarse powder, put in the percolation jar, be the percolate percolation with 0.1% hydrochloric acid solution to Radix Sophorae Flavescentis extract.Percolate to reddish brown, take out resin and puts airing in the enamel tray with distillation current resin column by behind the strongly acidic cation-exchange post, adds the 10% ammonia resin that alkalizes in right amount, after stirring, uses the chloroform solution reflux, extract.Filter, filtrate is used the anhydrous sodium sulfite drying, filters, and reclaims chloroform, gets Radix Sophorae Flavescentis extract.
5. Fructus Capsici extract (latin name: capsicum annuumL)
Use the outsourcing commercially available prod.
It is reddish brown supernatant liquid that hair follicle of the present invention activates liquid, is applicable to seborrhea (android type) alopecia, remarkable result is also arranged improving aspects such as hair jewelry, expensive clothing and other valuables, dry hair, bifurcated, tarnish and scalp pruritus, dandruff is many, scalp pomade is many.
Description of drawings
Fig. 1 is the technological process of production figure that hair follicle of the present invention activates liquid.
As shown in the figure, hair follicle of the present invention activates the production technology employing conventional method of liquid.
The specific embodiment
The specific embodiment of the present invention is described by the following examples.
(embodiment 1～5)
In an embodiment, Radix Ginseng extract, Herb Gynostemmae Pentaphylli extract, Radix Glycyrrhizae extract, Radix Sophorae Flavescentis extract use ZHANGGUANG company product, and Fructus Capsici extract uses the outsourcing product.
Proportioning by following table 1 takes by weighing Radix Ginseng extract, Herb Gynostemmae Pentaphylli extract, Radix Glycyrrhizae extract, Radix Sophorae Flavescentis extract, Fructus Capsici extract respectively, places 75% the abundant stirring and dissolving of alcoholic solution, places after 12 hours, filters and obtains reddish brown clarifying fluid product.
Table 1
| Component | Proportioning (parts by weight) | ||||
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | |
| Radix Ginseng extract | 0.175 | 0.235 | 0.350 | 0.438 | 0.585 |
| Herb Gynostemmae Pentaphylli extract | 0.126 | 0.168 | 0.252 | 0.315 | 0.420 |
| Radix Glycyrrhizae extract | 0.100 | 0.136 | 0.204 | 0.255 | 0.340 |
| Radix Sophorae Flavescentis extract | 0.095 | 0.126 | 0.190 | 0.237 | 0.316 |
| Fructus Capsici extract | 0.0036 | 0.0048 | 0.0072 | 0.009 | 0.012 |
| Ethanol (75%) | 100 | 100 | 100 | 100 | 100 |
(result of use)
Use the goods of the foregoing description 1 ~ 5, every example is randomly drawed 10 middle and advanced stage seborrheic alopecia persons and is carried out functional experiment, and the result is as follows:
1. use the effect of embodiment 1 goods
The experimenter uses the hair follicle that embodiment 1 makes to activate liquid, first three day scalp all feel slight fever, the slight fever phenomenon fades away after 3 days.Use after 1 month, have 6 people to grow floss, re-use 1 month after, 6 people grow tubbiness and send out, and have 2 people to grow floss again.2 people are invalid.
2. use the effect of embodiment 2 goods
The hair follicle that the experimenter uses embodiment 2 to make activates liquid, and scalp is all felt slight fever in 10 days, has 4 people's slight fever phenomenons to fade away after 10 days.The slight fever phenomenon all weakens disappearance after 15 days.Use after 20 days, have 7 people to grow floss, re-use 1 month after, 7 people grow tubbiness and send out, and have 2 people to grow floss again.1 people is invalid.
3. use the effect of embodiment 3 goods
The hair follicle that the experimenter uses embodiment 3 to make activates liquid, and scalp is all felt slight fever in 15 days, and wherein 1 people feels scorching hot slightly, and slight fever and scorching hot phenomenon fade away after 20 days.Use after 18 days, have 6 people to grow floss, re-use 1 month after, 7 people grow tubbiness and send out, and have 2 people to grow floss again.1 people is invalid.There are 2 people's scalps general red, recover after a few days.
4. use the effect of embodiment 4 goods
The hair follicle that the experimenter uses embodiment 4 to make activates liquid, and scalp is all felt slight fever in 20 days, and wherein 2 people feel scorching hot slightly, and these phenomenons fade away after 30 days.Use after 18 days, have 6 people to grow floss, re-use 1 month after, 7 people grow tubbiness and send out, and have 2 people to grow floss again.1 people is invalid.There are 3 people's scalps general red, recover after a few days.
5. use the effect of embodiment 5 goods
The hair follicle that the experimenter uses embodiment 4 to make activates liquid, and use scalp on the same day all begins to feel scorching hot, and continues 45 days.Use after 15 days, have 7 people to grow floss, re-use 1 month after, 7 people grow tubbiness and send out, and have 2 people to grow floss again.There are 3 people's scalps rubescent, recover after a few days.
The above-mentioned hair follicle of the present invention that experiment showed, that the proportioning of using embodiment 1～5 is made activates liquid, and can show lands promotes the growth of middle and advanced stage seborrheic alopecia person hair
In addition, hair follicle of the present invention activates liquid because its effective ingredient is traditional Chinese herbal medicine, thus in above-mentioned experimentation, the experimenter except feel to generate heat or feeling of having scorching hot, do not produce other adverse side effect, therefore can relievedly use.
As mentioned above, though it is a kind of special cosmetics rather than medicine that the hair follicle that is used to improve alopecia of the present invention activates liquid, but, because the active matter that hair follicle activation liquid of the present invention contains is the necessary material of hair follicle cell growth metabolism, local topical can directly infiltrate into the hair follicle deep layer, so can make hair follicle obtain competent nourishing, can suppress simultaneously the too much secretion of sebaceous gland, improve the oils and fats thromboembolism in the follicular orifice, promote the scalp blood circulation, increase blood flow, thereby make hair be able to ramp.Hair follicle of the present invention activates liquid and is specially adapted to the middle and advanced stage seborrheic alopecia.
Claims (1)
1. a hair follicle that is used to improve alopecia activates liquid, it is characterized in that, take by weighing Radix Ginseng extract, Herb Gynostemmae Pentaphylli extract, Radix Glycyrrhizae extract, Radix Sophorae Flavescentis extract, Fructus Capsici extract respectively by following proportioning, place 75% the abundant stirring and dissolving of alcoholic solution, place after 12 hours, filtration obtains reddish brown clarifying fluid product
Radix Ginseng extract: 0.175～0.585 parts by weight; Herb Gynostemmae Pentaphylli extract: 0.126～0.420 parts by weight; Radix Glycyrrhizae extract: 0.100～0.340 parts by weight; Radix Sophorae Flavescentis extract: 0.095～0.316 parts by weight; Fructus Capsici extract: 0.0036～0.012 parts by weight; 75% ethanol: 100 parts by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02155404 CN1212137C (en) | 2002-12-06 | 2002-12-06 | Hair follice activating liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02155404 CN1212137C (en) | 2002-12-06 | 2002-12-06 | Hair follice activating liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1506103A CN1506103A (en) | 2004-06-23 |
| CN1212137C true CN1212137C (en) | 2005-07-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02155404 Expired - Lifetime CN1212137C (en) | 2002-12-06 | 2002-12-06 | Hair follice activating liquid |
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| CN (1) | CN1212137C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168061A (en) * | 2015-09-24 | 2015-12-23 | 苏州科豪生物制品有限公司 | Shampoo and preparation method thereof |
| CN106075390A (en) * | 2016-07-28 | 2016-11-09 | 广东药科大学 | A kind of positively charged anticreep composite and flexible liposome and preparation method thereof |
| CN106880693A (en) * | 2017-03-22 | 2017-06-23 | 广州国草夏方生物科技有限公司 | It is a kind of to treat hair growth liquor composition of alopecia seborrheica and preparation method thereof |
| CN109498742A (en) * | 2018-12-27 | 2019-03-22 | 广州环亚化妆品科技有限公司 | A kind of Chinese medicine composition and its preparation method and application promoting scalp hair follicles energetic supersession |
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2002
- 2002-12-06 CN CN 02155404 patent/CN1212137C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1506103A (en) | 2004-06-23 |
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Owner name: BEIJING ZHANGGUANG 101 SCIENCE & TECHNOLOGY CO., Free format text: FORMER OWNER: ZHAO ZHANGGUANG Effective date: 20081107 |
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Effective date of registration: 20081107 Address after: No. 4 middle Yongchang Road, Beijing economic and Technological Development Zone, Beijing Patentee after: BEIJING ZHANGGUANG 101 TECHNOLOGY Co.,Ltd. Address before: No. 4 middle Yongchang Road, Beijing economic and Technological Development Zone, Beijing Patentee before: Zhao Zhangguang |
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Granted publication date: 20050727 |