CN113350254A - Anti-inflammation hemostatic toothpaste composition and preparation method thereof - Google Patents
Anti-inflammation hemostatic toothpaste composition and preparation method thereof Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract description 106
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 83
- 239000000606 toothpaste Substances 0.000 title claims abstract description 83
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 56
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 124
- 238000003756 stirring Methods 0.000 claims abstract description 73
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 62
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 48
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 45
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 45
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 45
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229940085605 saccharin sodium Drugs 0.000 claims abstract description 38
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims abstract description 38
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims abstract description 38
- 230000008719 thickening Effects 0.000 claims abstract description 31
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims abstract description 30
- 239000003814 drug Substances 0.000 claims abstract description 30
- 239000006072 paste Substances 0.000 claims abstract description 30
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 24
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 24
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 24
- 239000000049 pigment Substances 0.000 claims abstract description 24
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 24
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 24
- 239000000600 sorbitol Substances 0.000 claims abstract description 24
- 238000005303 weighing Methods 0.000 claims abstract description 23
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000230 xanthan gum Substances 0.000 claims abstract description 17
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 17
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 17
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 17
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 30
- 239000002245 particle Substances 0.000 claims description 29
- 239000006041 probiotic Substances 0.000 claims description 29
- 230000000529 probiotic effect Effects 0.000 claims description 29
- 235000018291 probiotics Nutrition 0.000 claims description 29
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 claims description 28
- 235000009604 Chrysanthemum X morifolium Nutrition 0.000 claims description 21
- 244000189548 Chrysanthemum x morifolium Species 0.000 claims description 21
- 240000003915 Lophatherum gracile Species 0.000 claims description 21
- 239000000126 substance Substances 0.000 claims description 15
- 239000004408 titanium dioxide Substances 0.000 claims description 15
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 15
- 229940068475 zinc citrate Drugs 0.000 claims description 15
- 235000006076 zinc citrate Nutrition 0.000 claims description 15
- 239000011746 zinc citrate Substances 0.000 claims description 15
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 14
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 14
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 14
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 14
- 239000013078 crystal Substances 0.000 claims description 14
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 14
- 239000003205 fragrance Substances 0.000 claims description 14
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 claims description 14
- 229940041616 menthol Drugs 0.000 claims description 14
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 14
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 14
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 14
- 230000004054 inflammatory process Effects 0.000 claims description 9
- 230000000740 bleeding effect Effects 0.000 claims description 8
- 230000003467 diminishing effect Effects 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 7
- 239000002674 ointment Substances 0.000 claims description 7
- 238000005070 sampling Methods 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims 3
- 206010018276 Gingival bleeding Diseases 0.000 abstract description 14
- 208000034619 Gingival inflammation Diseases 0.000 abstract description 5
- 238000004140 cleaning Methods 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 239000000686 essence Substances 0.000 abstract 2
- 230000001194 anti-hemostatic effect Effects 0.000 abstract 1
- 229940083575 sodium dodecyl sulfate Drugs 0.000 abstract 1
- 230000023597 hemostasis Effects 0.000 description 14
- 208000032843 Hemorrhage Diseases 0.000 description 6
- 208000034158 bleeding Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 208000011759 gum bleeding Diseases 0.000 description 4
- 241000411851 herbal medicine Species 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 3
- 229940126680 traditional chinese medicines Drugs 0.000 description 3
- 208000010641 Tooth disease Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229940041667 oral paste Drugs 0.000 description 1
- 210000004261 periodontium Anatomy 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses an anti-inflammation hemostatic toothpaste composition and a preparation method thereof, and relates to the technical field of toothpaste processing. The anti-inflammatory and hemostatic toothpaste composition comprises the following components: sorbitol, PEG-400, sodium carboxymethylcellulose, xanthan gum, saccharin sodium, tetrasodium pyrophosphate, sodium benzoate, a traditional Chinese medicine composition, thickening silicon dioxide, cleaning silicon dioxide, sodium dodecyl sulfate, essence, pigment and the balance of water; the preparation method comprises the following steps: adding sorbitol and PEG-400 into paste making machine, weighing water to pre-mixing tank, adding saccharin sodium, tetrasodium pyrophosphate and sodium benzoate, stirring, sequentially adding thickening silicon dioxide, sodium carboxymethylcellulose, xanthan gum, sodium dodecyl sulfate and clean silicon dioxide, stirring, transferring paste making machine, weighing Chinese medicinal composition, essence and pigment, stirring, and stopping scraper. The preparation method is simple, and the condition of gingival bleeding caused by gingival inflammation can be effectively improved.
Description
Technical Field
The invention relates to the technical field of toothpaste processing, in particular to an anti-inflammation and hemostasis toothpaste composition and a preparation method thereof.
Background
With the development of society, the quality of life of people is continuously improved, the daily diet is also improved, various tooth diseases follow the daily diet, and gum bleeding is one of the most common tooth diseases. The causes of gum bleeding are many, and gum bleeding caused by oral local factors is the most common. In order to solve these problems, attention must be paid to tooth cleaning to reduce the generation of plaque and tartar. Secondly, the gum nutrition is supplemented, the gum is repaired, and the gum immunity is improved, so that the problems of gum bleeding, inflammation and the like can be fundamentally solved.
Related products exist for preventing and treating periodontitis through the Chinese herbal medicine toothpaste, however, because the Chinese herbal medicine mucous membrane penetration research is not deep yet, Chinese herbal medicine components in the toothpaste are rarely absorbed in periodontium, and the effect of the Chinese herbal medicine toothpaste on periodontitis is not obvious. At present, the research on the permeation promoting effect of traditional Chinese medicines mainly focuses on the permeation promoting effect of traditional Chinese medicines on chemical medicines, and the reports on the mutual permeation promoting effect among the traditional Chinese medicines are few. This is probably because the compound Chinese medicine preparation has more medicinal taste and complex components, which brings certain difficulty for quantitative research of the medicine in vivo and in vitro, but also suggests that the penetration promotion research among the medicines in the compound Chinese medicine preparation has great potential.
Disclosure of Invention
The invention aims to provide an anti-inflammation hemostatic toothpaste composition and a preparation method thereof, which can effectively improve the current situation of gingival bleeding caused by gingival inflammation.
In order to achieve the above purpose, the invention provides an anti-inflammation hemostatic toothpaste composition and a preparation method thereof, wherein the anti-inflammation hemostatic toothpaste composition is prepared from the following components in percentage by weight:
30 to 75 percent of sorbitol,
PEG-400 1％-5％，
0.2 to 1.5 percent of sodium carboxymethyl cellulose,
0.1 to 1.0 percent of xanthan gum,
0.1 to 0.4 percent of saccharin sodium,
tetrasodium pyrophosphate 0.1% -1.0%,
0.1 to 0.3 percent of sodium benzoate,
0.1 to 2.0 percent of traditional Chinese medicine composition,
5 to 10 percent of thickening silicon dioxide,
8 to 20 percent of clean silicon dioxide,
1.0 to 2.5 percent of sodium dodecyl sulfate,
1 to 1.5 percent of essence,
1 to 1.5 percent of pigment,
the balance being water.
The anti-inflammation hemostatic toothpaste composition is prepared from the following components in percentage by weight:
35 to 70 percent of sorbitol,
PEG-400 1％-5％，
0.2 to 1.5 percent of sodium carboxymethyl cellulose,
0.1 to 1.0 percent of xanthan gum,
0.1 to 0.4 percent of saccharin sodium,
tetrasodium pyrophosphate 0.1% -1.0%,
0.1 to 0.3 percent of sodium benzoate,
0.2 to 0.6 percent of traditional Chinese medicine composition,
5 to 10 percent of thickening silicon dioxide,
8 to 20 percent of clean silicon dioxide,
1.0 to 2.5 percent of sodium dodecyl sulfate,
1 to 1.5 percent of essence,
1 to 1.5 percent of pigment,
the balance being water.
The anti-inflammation hemostatic toothpaste composition is prepared from the following components in percentage by weight:
50 percent of sorbitol,
PEG-400 3％，
1.1 percent of sodium carboxymethyl cellulose,
0.6 percent of xanthan gum,
0.2 percent of saccharin sodium,
0.6 percent of tetrasodium pyrophosphate,
0.2 percent of sodium benzoate,
0.4 percent of the traditional Chinese medicine composition,
8 percent of thickening silicon dioxide,
12 percent of clean silicon dioxide,
1.8 percent of sodium dodecyl sulfate,
1.2 percent of essence,
1.2 percent of pigment,
the balance being water.
The anti-inflammatory hemostatic toothpaste composition is characterized in that the PEG-400 is purchased from Jinan crystal Hao chemical Co., Ltd, and the model number of the PEG-400 is TS 7;
the sodium carboxymethylcellulose is purchased from Jinan crystal Hao chemical company Limited and has the model number TH 9.
The anti-inflammation hemostatic toothpaste composition is characterized in that the thickening silica is purchased from Guangzhou Gangsheng New Material Co., Ltd, and the model number of the thickening silica is 10-2 #;
the clean silicon dioxide is purchased from Guangzhou Highl New Material Co., Ltd, and the model number of the clean silicon dioxide is 10# -1 #.
The essence of the anti-inflammation hemostatic toothpaste composition is purchased from Youdou Homophilus Biotech limited company, and the type number of the essence is DJ-4345;
the pigment is purchased from Zhengzhou Hengren chemotherapeutics products Co., Ltd, and the model number is SC 20141072100199.
The traditional Chinese medicine composition of the anti-inflammation and hemostasis toothpaste composition comprises a lophatherum gracile extract, a chrysanthemum morifolium extract, dipotassium glycyrrhizinate, menthol and paeonol, wherein the lophatherum gracile extract and the chrysanthemum morifolium extract are purchased from Guangzhou Yuejiao Kogyo Co., Ltd, and the dosage ratio of the lophatherum gracile extract, the chrysanthemum morifolium extract, the dipotassium glycyrrhizinate, the menthol and the paeonol is (0.1-1): (0.01-0.5): (0.01-0.5): (0.1-1): (0.01-0.5).
The preparation method of the anti-inflammation hemostatic toothpaste composition comprises the following steps:
(1) adding sorbitol and PEG-400 into a paste making machine according to the formula amount; simultaneously reserving sorbitol for washing the water-phase premixing pot;
(2) weighing water according to the formula amount, adding saccharin sodium, tetrasodium pyrophosphate and sodium benzoate according to the formula amount into a premixing tank, stirring for 15 minutes, stopping stirring, observing whether the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved, and continuously stirring until the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved if the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are not dissolved; wherein the vacuum degree is controlled to be-0.04 MPa to-0.08 MPa and then the mixture enters a paste making machine;
(3) adding thickening type silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, sodium dodecyl sulfate and clean type silicon dioxide into a powder premixing and stirring pot according to the formula amount, and stirring for 5 minutes;
(4) controlling the vacuum degree to be-0.04 Mpa to-0.08 Mpa, sucking the powder obtained in the step (3) into a paste making machine, simultaneously opening double stirring blades and stirring for 15 minutes;
(5) weighing the traditional Chinese medicine composition, the essence and the pigment according to the formula, opening a fragrance inlet valve, sucking the substances, closing the fragrance inlet valve, starting a vacuum pump, stirring for 15 minutes, stopping stirring, starting the vacuum pump, and continuing stirring by a scraper for 10 minutes, wherein the vacuum degree is not lower than-0.096 Mpa before ointment discharge;
(6) stopping the scraper, slowly opening an air release valve, recovering the normal pressure, and sampling and inspecting;
(7) and (5) obtaining paste after the detection is qualified.
The preparation method of the anti-inflammation hemostatic toothpaste composition comprises the step (2) of adding sodium monofluorophosphate according to the formula amount, wherein the amount of the sodium monofluorophosphate is 2 times of the amount of the sodium benzoate;
the step (3) also comprises the following components: zinc citrate, probiotic particles and titanium dioxide, wherein the dosage ratio of the zinc citrate to the probiotic particles to the titanium dioxide is 5: 1: 2; wherein the dosage of the probiotic particles is 1.5 times of the dosage of the sodium dodecyl sulfate; wherein the probiotic particles are purchased from Guangzhou Yuejiao industries, Inc.
According to the preparation method of the anti-inflammation and hemostasis toothpaste composition, step (5) also comprises weighing sodium lauroyl sarcosine according to the formula amount, wherein the dosage of the sodium lauroyl sarcosine is 3 times of that of the essence.
The anti-inflammation hemostatic toothpaste composition and the preparation method thereof provided by the technical scheme have the following beneficial effects:
compared with the prior art, the anti-inflammation hemostasis toothpaste composition is simple in preparation method and capable of effectively improving gingival bleeding caused by gingival inflammation. Particularly, various compositions in the traditional Chinese medicine composition are fully utilized as raw materials, effective fusion reaction is carried out through zinc citrate, probiotic particles and titanium dioxide, no adverse reaction is caused when the traditional Chinese medicine composition is used, and the condition of gingival bleeding is effectively relieved.
Detailed Description
The following examples are given to further illustrate the embodiments of the present invention. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1
The toothpaste composition for diminishing inflammation and stopping bleeding and the preparation method thereof of the embodiment comprise the following components in percentage by weight:
30 percent of sorbitol,
PEG-400 5％，
0.2 percent of sodium carboxymethyl cellulose,
1.0 percent of xanthan gum,
0.1 percent of saccharin sodium,
1.0 percent of tetrasodium pyrophosphate,
0.1 percent of sodium benzoate,
0.1 percent of the traditional Chinese medicine composition,
5 percent of thickening silicon dioxide,
20 percent of clean silicon dioxide,
1.0 percent of sodium dodecyl sulfate,
1.5 percent of essence,
1 percent of pigment,
the balance being water.
The anti-inflammatory hemostatic toothpaste composition is characterized in that the PEG-400 is purchased from Jinan crystal Hao chemical Co., Ltd, and the model number of the PEG-400 is TS 7;
the sodium carboxymethylcellulose is purchased from Jinan crystal Hao chemical company Limited and has the model number TH 9.
The anti-inflammation hemostatic toothpaste composition is characterized in that the thickening silica is purchased from Guangzhou Gangsheng New Material Co., Ltd, and the model number of the thickening silica is 10-2 #;
the clean silicon dioxide is purchased from Guangzhou Highl New Material Co., Ltd, and the model number of the clean silicon dioxide is 10# -1 #.
The essence of the anti-inflammation hemostatic toothpaste composition is purchased from Youdou Homophilus Biotech limited company, and the type number of the essence is DJ-4345;
the pigment is purchased from Zhengzhou Hengren chemotherapeutics products Co., Ltd, and the model number is SC 20141072100199.
The traditional Chinese medicine composition of the anti-inflammation and hemostasis toothpaste composition comprises a lophatherum gracile extract, a chrysanthemum morifolium extract, dipotassium glycyrrhizinate, menthol and paeonol, wherein the lophatherum gracile extract and the chrysanthemum morifolium extract are purchased from Guangzhou Yuejiao industries, ltd, and the dosage ratio of the lophatherum gracile extract, the chrysanthemum morifolium extract, the dipotassium glycyrrhizinate, the menthol and the paeonol is 0.1: 0.01: 0.01: 0.1: 0.01.
the preparation method of the anti-inflammation hemostatic toothpaste composition comprises the following steps:
(1) adding sorbitol and PEG-400 into a paste making machine according to the formula amount; simultaneously reserving sorbitol for washing the water-phase premixing pot;
(2) weighing water according to the formula amount, adding saccharin sodium, tetrasodium pyrophosphate and sodium benzoate according to the formula amount into a premixing tank, stirring for 15 minutes, stopping stirring, observing whether the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved, and continuously stirring until the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved if the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are not dissolved; wherein the vacuum degree is controlled to be-0.04 MPa to-0.08 MPa and then the mixture enters a paste making machine;
(3) adding thickening type silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, sodium dodecyl sulfate and clean type silicon dioxide into a powder premixing and stirring pot according to the formula amount, and stirring for 5 minutes;
(4) controlling the vacuum degree to be-0.04 Mpa to-0.08 Mpa, sucking the powder obtained in the step (3) into a paste making machine, simultaneously opening double stirring blades and stirring for 15 minutes;
(5) weighing the traditional Chinese medicine composition, the essence and the pigment according to the formula, opening a fragrance inlet valve, sucking the substances, closing the fragrance inlet valve, starting a vacuum pump, stirring for 15 minutes, stopping stirring, starting the vacuum pump, and continuing stirring by a scraper for 10 minutes, wherein the vacuum degree is not lower than-0.096 Mpa before ointment discharge;
(6) stopping the scraper, slowly opening an air release valve, recovering the normal pressure, and sampling and inspecting;
(7) and (5) obtaining paste after the detection is qualified.
The preparation method of the anti-inflammation hemostatic toothpaste composition comprises the step (2) of adding sodium monofluorophosphate according to the formula amount, wherein the amount of the sodium monofluorophosphate is 2 times of the amount of the sodium benzoate;
the step (3) also comprises the following components: zinc citrate, probiotic particles and titanium dioxide, wherein the dosage ratio of the zinc citrate to the probiotic particles to the titanium dioxide is 5: 1: 2; wherein the dosage of the probiotic particles is 1.5 times of the dosage of the sodium dodecyl sulfate; wherein the probiotic particles are purchased from Guangzhou Yuejiao industries, Inc.
According to the preparation method of the anti-inflammation and hemostasis toothpaste composition, step (5) also comprises weighing sodium lauroyl sarcosine according to the formula amount, wherein the dosage of the sodium lauroyl sarcosine is 3 times of that of the essence.
Example 2
The toothpaste composition for diminishing inflammation and stopping bleeding and the preparation method thereof of the embodiment comprise the following components in percentage by weight:
sorbitol accounts for 75 percent,
PEG-400 1％，
1.5 percent of sodium carboxymethyl cellulose,
0.1 percent of xanthan gum,
0.4 percent of saccharin sodium,
0.1 percent of tetrasodium pyrophosphate,
0.3 percent of sodium benzoate,
1.0 percent of the traditional Chinese medicine composition,
10 percent of thickening silicon dioxide,
8 percent of clean silicon dioxide,
2.5 percent of sodium dodecyl sulfate,
1 percent of essence,
1.5 percent of pigment,
the balance being water.
The anti-inflammatory hemostatic toothpaste composition is characterized in that the PEG-400 is purchased from Jinan crystal Hao chemical Co., Ltd, and the model number of the PEG-400 is TS 7;
the sodium carboxymethylcellulose is purchased from Jinan crystal Hao chemical company Limited and has the model number TH 9.
The anti-inflammation hemostatic toothpaste composition is characterized in that the thickening silica is purchased from Guangzhou Gangsheng New Material Co., Ltd, and the model number of the thickening silica is 10-2 #;
the clean silicon dioxide is purchased from Guangzhou Highl New Material Co., Ltd, and the model number of the clean silicon dioxide is 10# -1 #.
The essence of the anti-inflammation hemostatic toothpaste composition is purchased from Youdou Homophilus Biotech limited company, and the type number of the essence is DJ-4345;
the pigment is purchased from Zhengzhou Hengren chemotherapeutics products Co., Ltd, and the model number is SC 20141072100199.
The traditional Chinese medicine composition of the anti-inflammation and hemostasis toothpaste composition comprises a lophatherum gracile extract, a chrysanthemum morifolium extract, dipotassium glycyrrhizinate, menthol and paeonol, wherein the lophatherum gracile extract and the chrysanthemum morifolium extract are purchased from Guangzhou Yuejiao industries, ltd, and the dosage ratio of the lophatherum gracile extract, the chrysanthemum morifolium extract, the dipotassium glycyrrhizinate, the menthol and the paeonol is 1: 0.5: 0.5: 1: 0.5.
the preparation method of the anti-inflammation hemostatic toothpaste composition comprises the following steps:
(1) adding sorbitol and PEG-400 into a paste making machine according to the formula amount; simultaneously reserving sorbitol for washing the water-phase premixing pot;
(2) weighing water according to the formula amount, adding saccharin sodium, tetrasodium pyrophosphate and sodium benzoate according to the formula amount into a premixing tank, stirring for 15 minutes, stopping stirring, observing whether the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved, and continuously stirring until the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved if the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are not dissolved; wherein the vacuum degree is controlled to be-0.04 MPa to-0.08 MPa and then the mixture enters a paste making machine;
(3) adding thickening type silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, sodium dodecyl sulfate and clean type silicon dioxide into a powder premixing and stirring pot according to the formula amount, and stirring for 5 minutes;
(4) controlling the vacuum degree to be-0.04 Mpa to-0.08 Mpa, sucking the powder obtained in the step (3) into a paste making machine, simultaneously opening double stirring blades and stirring for 15 minutes;
(5) weighing the traditional Chinese medicine composition, the essence and the pigment according to the formula, opening a fragrance inlet valve, sucking the substances, closing the fragrance inlet valve, starting a vacuum pump, stirring for 15 minutes, stopping stirring, starting the vacuum pump, and continuing stirring by a scraper for 10 minutes, wherein the vacuum degree is not lower than-0.096 Mpa before ointment discharge;
(6) stopping the scraper, slowly opening an air release valve, recovering the normal pressure, and sampling and inspecting;
(7) and (5) obtaining paste after the detection is qualified.
The preparation method of the anti-inflammation hemostatic toothpaste composition comprises the step (2) of adding sodium monofluorophosphate according to the formula amount, wherein the amount of the sodium monofluorophosphate is 2 times of the amount of the sodium benzoate;
the step (3) also comprises the following components: zinc citrate, probiotic particles and titanium dioxide, wherein the dosage ratio of the zinc citrate to the probiotic particles to the titanium dioxide is 5: 1: 2; wherein the dosage of the probiotic particles is 1.5 times of the dosage of the sodium dodecyl sulfate; wherein the probiotic particles are purchased from Guangzhou Yuejiao industries, Inc.
According to the preparation method of the anti-inflammation and hemostasis toothpaste composition, step (5) also comprises weighing sodium lauroyl sarcosine according to the formula amount, wherein the dosage of the sodium lauroyl sarcosine is 3 times of that of the essence.
Example 3
The toothpaste composition for diminishing inflammation and stopping bleeding and the preparation method thereof of the embodiment comprise the following components in percentage by weight:
35 percent of sorbitol,
PEG-400 5％，
0.2 percent of sodium carboxymethyl cellulose,
1.0 percent of xanthan gum,
0.1 percent of saccharin sodium,
1.0 percent of tetrasodium pyrophosphate,
0.1 percent of sodium benzoate,
0.2 percent of the traditional Chinese medicine composition,
5 percent of thickening silicon dioxide,
20 percent of clean silicon dioxide,
1.0 percent of sodium dodecyl sulfate,
1.5 percent of essence,
1 percent of pigment,
the balance being water.
The anti-inflammatory hemostatic toothpaste composition is characterized in that the PEG-400 is purchased from Jinan crystal Hao chemical Co., Ltd, and the model number of the PEG-400 is TS 7;
the sodium carboxymethylcellulose is purchased from Jinan crystal Hao chemical company Limited and has the model number TH 9.
The anti-inflammation hemostatic toothpaste composition is characterized in that the thickening silica is purchased from Guangzhou Gangsheng New Material Co., Ltd, and the model number of the thickening silica is 10-2 #;
the clean silicon dioxide is purchased from Guangzhou Highl New Material Co., Ltd, and the model number of the clean silicon dioxide is 10# -1 #.
The essence of the anti-inflammation hemostatic toothpaste composition is purchased from Youdou Homophilus Biotech limited company, and the type number of the essence is DJ-4345;
the pigment is purchased from Zhengzhou Hengren chemotherapeutics products Co., Ltd, and the model number is SC 20141072100199.
The traditional Chinese medicine composition of the anti-inflammation and hemostasis toothpaste composition comprises a lophatherum gracile extract, a chrysanthemum morifolium extract, dipotassium glycyrrhizinate, menthol and paeonol, wherein the lophatherum gracile extract and the chrysanthemum morifolium extract are purchased from Guangzhou Yuejiao industries, ltd, and the dosage ratio of the lophatherum gracile extract, the chrysanthemum morifolium extract, the dipotassium glycyrrhizinate, the menthol and the paeonol is 0.1: 0.5: 0.01: 1: 0.01.
the preparation method of the anti-inflammation hemostatic toothpaste composition comprises the following steps:
(1) adding sorbitol and PEG-400 into a paste making machine according to the formula amount; simultaneously reserving sorbitol for washing the water-phase premixing pot;
(2) weighing water according to the formula amount, adding saccharin sodium, tetrasodium pyrophosphate and sodium benzoate according to the formula amount into a premixing tank, stirring for 15 minutes, stopping stirring, observing whether the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved, and continuously stirring until the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved if the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are not dissolved; wherein the vacuum degree is controlled to be-0.04 MPa to-0.08 MPa and then the mixture enters a paste making machine;
(3) adding thickening type silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, sodium dodecyl sulfate and clean type silicon dioxide into a powder premixing and stirring pot according to the formula amount, and stirring for 5 minutes;
(4) controlling the vacuum degree to be-0.04 Mpa to-0.08 Mpa, sucking the powder obtained in the step (3) into a paste making machine, simultaneously opening double stirring blades and stirring for 15 minutes;
(5) weighing the traditional Chinese medicine composition, the essence and the pigment according to the formula, opening a fragrance inlet valve, sucking the substances, closing the fragrance inlet valve, starting a vacuum pump, stirring for 15 minutes, stopping stirring, starting the vacuum pump, and continuing stirring by a scraper for 10 minutes, wherein the vacuum degree is not lower than-0.096 Mpa before ointment discharge;
(6) stopping the scraper, slowly opening an air release valve, recovering the normal pressure, and sampling and inspecting;
(7) and (5) obtaining paste after the detection is qualified.
The preparation method of the anti-inflammation hemostatic toothpaste composition comprises the step (2) of adding sodium monofluorophosphate according to the formula amount, wherein the amount of the sodium monofluorophosphate is 2 times of the amount of the sodium benzoate;
the step (3) also comprises the following components: zinc citrate, probiotic particles and titanium dioxide, wherein the dosage ratio of the zinc citrate to the probiotic particles to the titanium dioxide is 5: 1: 2; wherein the dosage of the probiotic particles is 1.5 times of the dosage of the sodium dodecyl sulfate; wherein the probiotic particles are purchased from Guangzhou Yuejiao industries, Inc.
According to the preparation method of the anti-inflammation and hemostasis toothpaste composition, step (5) also comprises weighing sodium lauroyl sarcosine according to the formula amount, wherein the dosage of the sodium lauroyl sarcosine is 3 times of that of the essence.
Example 4
The toothpaste composition for diminishing inflammation and stopping bleeding and the preparation method thereof of the embodiment comprise the following components in percentage by weight:
70 percent of sorbitol,
PEG-400 1％，
1.5 percent of sodium carboxymethyl cellulose,
0.1 percent of xanthan gum,
0.4 percent of saccharin sodium,
0.1 percent of tetrasodium pyrophosphate,
0.3 percent of sodium benzoate,
0.6 percent of the traditional Chinese medicine composition,
10 percent of thickening silicon dioxide,
8 percent of clean silicon dioxide,
2.5 percent of sodium dodecyl sulfate,
1 percent of essence,
1.5 percent of pigment,
the balance being water.
The anti-inflammatory hemostatic toothpaste composition is characterized in that the PEG-400 is purchased from Jinan crystal Hao chemical Co., Ltd, and the model number of the PEG-400 is TS 7;
the sodium carboxymethylcellulose is purchased from Jinan crystal Hao chemical company Limited and has the model number TH 9.
The anti-inflammation hemostatic toothpaste composition is characterized in that the thickening silica is purchased from Guangzhou Gangsheng New Material Co., Ltd, and the model number of the thickening silica is 10-2 #;
the clean silicon dioxide is purchased from Guangzhou Highl New Material Co., Ltd, and the model number of the clean silicon dioxide is 10# -1 #.
The essence of the anti-inflammation hemostatic toothpaste composition is purchased from Youdou Homophilus Biotech limited company, and the type number of the essence is DJ-4345;
the pigment is purchased from Zhengzhou Hengren chemotherapeutics products Co., Ltd, and the model number is SC 20141072100199.
The traditional Chinese medicine composition of the anti-inflammation and hemostasis toothpaste composition comprises a lophatherum gracile extract, a chrysanthemum morifolium extract, dipotassium glycyrrhizinate, menthol and paeonol, wherein the lophatherum gracile extract and the chrysanthemum morifolium extract are purchased from Guangzhou Yuejiao industries, ltd, and the dosage ratio of the lophatherum gracile extract, the chrysanthemum morifolium extract, the dipotassium glycyrrhizinate, the menthol and the paeonol is 1: 0.01: 0.5: 0.1: 0.5.
the preparation method of the anti-inflammation hemostatic toothpaste composition comprises the following steps:
(1) adding sorbitol and PEG-400 into a paste making machine according to the formula amount; simultaneously reserving sorbitol for washing the water-phase premixing pot;
(2) weighing water according to the formula amount, adding saccharin sodium, tetrasodium pyrophosphate and sodium benzoate according to the formula amount into a premixing tank, stirring for 15 minutes, stopping stirring, observing whether the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved, and continuously stirring until the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved if the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are not dissolved; wherein the vacuum degree is controlled to be-0.04 MPa to-0.08 MPa and then the mixture enters a paste making machine;
(3) adding thickening type silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, sodium dodecyl sulfate and clean type silicon dioxide into a powder premixing and stirring pot according to the formula amount, and stirring for 5 minutes;
(4) controlling the vacuum degree to be-0.04 Mpa to-0.08 Mpa, sucking the powder obtained in the step (3) into a paste making machine, simultaneously opening double stirring blades and stirring for 15 minutes;
(5) weighing the traditional Chinese medicine composition, the essence and the pigment according to the formula, opening a fragrance inlet valve, sucking the substances, closing the fragrance inlet valve, starting a vacuum pump, stirring for 15 minutes, stopping stirring, starting the vacuum pump, and continuing stirring by a scraper for 10 minutes, wherein the vacuum degree is not lower than-0.096 Mpa before ointment discharge;
(6) stopping the scraper, slowly opening an air release valve, recovering the normal pressure, and sampling and inspecting;
(7) and (5) obtaining paste after the detection is qualified.
The preparation method of the anti-inflammation hemostatic toothpaste composition comprises the step (2) of adding sodium monofluorophosphate according to the formula amount, wherein the amount of the sodium monofluorophosphate is 2 times of the amount of the sodium benzoate;
the step (3) also comprises the following components: zinc citrate, probiotic particles and titanium dioxide, wherein the dosage ratio of the zinc citrate to the probiotic particles to the titanium dioxide is 5: 1: 2; wherein the dosage of the probiotic particles is 1.5 times of the dosage of the sodium dodecyl sulfate; wherein the probiotic particles are purchased from Guangzhou Yuejiao industries, Inc.
According to the preparation method of the anti-inflammation and hemostasis toothpaste composition, step (5) also comprises weighing sodium lauroyl sarcosine according to the formula amount, wherein the dosage of the sodium lauroyl sarcosine is 3 times of that of the essence.
Example 5
The toothpaste composition for diminishing inflammation and stopping bleeding and the preparation method thereof of the embodiment comprise the following components in percentage by weight:
50 percent of sorbitol,
PEG-400 3％，
1.1 percent of sodium carboxymethyl cellulose,
0.6 percent of xanthan gum,
0.2 percent of saccharin sodium,
0.6 percent of tetrasodium pyrophosphate,
0.2 percent of sodium benzoate,
0.4 percent of the traditional Chinese medicine composition,
8 percent of thickening silicon dioxide,
12 percent of clean silicon dioxide,
1.8 percent of sodium dodecyl sulfate,
1.2 percent of essence,
1.2 percent of pigment,
the balance being water.
The anti-inflammatory hemostatic toothpaste composition is characterized in that the PEG-400 is purchased from Jinan crystal Hao chemical Co., Ltd, and the model number of the PEG-400 is TS 7;
the sodium carboxymethylcellulose is purchased from Jinan crystal Hao chemical company Limited and has the model number TH 9.
The anti-inflammation hemostatic toothpaste composition is characterized in that the thickening silica is purchased from Guangzhou Gangsheng New Material Co., Ltd, and the model number of the thickening silica is 10-2 #;
the clean silicon dioxide is purchased from Guangzhou Highl New Material Co., Ltd, and the model number of the clean silicon dioxide is 10# -1 #.
The essence of the anti-inflammation hemostatic toothpaste composition is purchased from Youdou Homophilus Biotech limited company, and the type number of the essence is DJ-4345;
the pigment is purchased from Zhengzhou Hengren chemotherapeutics products Co., Ltd, and the model number is SC 20141072100199.
The traditional Chinese medicine composition of the anti-inflammation and hemostasis toothpaste composition comprises a lophatherum gracile extract, a chrysanthemum morifolium extract, dipotassium glycyrrhizinate, menthol and paeonol, wherein the lophatherum gracile extract and the chrysanthemum morifolium extract are purchased from Guangzhou Yuejiao industries, ltd, and the dosage ratio of the lophatherum gracile extract, the chrysanthemum morifolium extract, the dipotassium glycyrrhizinate, the menthol and the paeonol is 0.6: 0.25: 0.25: 0.6: 0.25.
the preparation method of the anti-inflammation hemostatic toothpaste composition comprises the following steps:
(1) adding sorbitol and PEG-400 into a paste making machine according to the formula amount; simultaneously reserving sorbitol for washing the water-phase premixing pot;
(2) weighing water according to the formula amount, adding saccharin sodium, tetrasodium pyrophosphate and sodium benzoate according to the formula amount into a premixing tank, stirring for 15 minutes, stopping stirring, observing whether the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved, and continuously stirring until the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved if the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are not dissolved; wherein the vacuum degree is controlled to be-0.04 MPa to-0.08 MPa and then the mixture enters a paste making machine;
(3) adding thickening type silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, sodium dodecyl sulfate and clean type silicon dioxide into a powder premixing and stirring pot according to the formula amount, and stirring for 5 minutes;
(4) controlling the vacuum degree to be-0.04 Mpa to-0.08 Mpa, sucking the powder obtained in the step (3) into a paste making machine, simultaneously opening double stirring blades and stirring for 15 minutes;
(5) weighing the traditional Chinese medicine composition, the essence and the pigment according to the formula, opening a fragrance inlet valve, sucking the substances, closing the fragrance inlet valve, starting a vacuum pump, stirring for 15 minutes, stopping stirring, starting the vacuum pump, and continuing stirring by a scraper for 10 minutes, wherein the vacuum degree is not lower than-0.096 Mpa before ointment discharge;
(6) stopping the scraper, slowly opening an air release valve, recovering the normal pressure, and sampling and inspecting;
(7) and (5) obtaining paste after the detection is qualified.
The preparation method of the anti-inflammation hemostatic toothpaste composition comprises the step (2) of adding sodium monofluorophosphate according to the formula amount, wherein the amount of the sodium monofluorophosphate is 2 times of the amount of the sodium benzoate;
the step (3) also comprises the following components: zinc citrate, probiotic particles and titanium dioxide, wherein the dosage ratio of the zinc citrate to the probiotic particles to the titanium dioxide is 5: 1: 2; wherein the dosage of the probiotic particles is 1.5 times of the dosage of the sodium dodecyl sulfate; wherein the probiotic particles are purchased from Guangzhou Yuejiao industries, Inc.
According to the preparation method of the anti-inflammation and hemostasis toothpaste composition, step (5) also comprises weighing sodium lauroyl sarcosine according to the formula amount, wherein the dosage of the sodium lauroyl sarcosine is 3 times of that of the essence.
Test protocol
Taking the anti-inflammatory hemostatic toothpaste compositions prepared in examples 1-5 as an example, the following tests were performed:
treatment effect on gingival bleeding caused by gingival inflammation
490 patients suffering from gingival bleeding are randomly selected and divided into 7 groups, 70 patients in each group and 7 patients use the toothpaste of the embodiments 1-5 and the prior art 1-2 respectively, the toothpaste is used once in the morning and at night every day for 2 months, then the condition of each group of patients is counted, the gingival bleeding is improved, and the gingival bleeding is treated basically effectively. It should be reminded that the toothpaste of the prior art 1 is the shuke safflower fire-clearing toothpaste produced by Guangzhou Wei Meizi industry Co., Ltd, and the toothpaste of the prior art 2 is the anti-inflammatory hemostatic biological oral paste produced by Guangzhou Yi ya oral products Co., Ltd.
TABLE 1 Effect status
| Significant efficiency (%) | Effective rate (%) | Total treatment Rate (%) | |
| Example 1 | 76.9 | 12.5 | 89.4 |
| Example 2 | 77.2 | 12.6 | 89.8 |
| Example 3 | 78.0 | 13.4 | 91.4 |
| Example 4 | 78.1 | 13.2 | 91.3 |
| Example 5 | 79.5 | 15.0 | 94.5 |
| Prior art 1 | 51.8 | 16.7 | 68.5 |
| Prior art 2 | 42.5 | 12.1 | 54.6 |
As can be seen from Table 1, compared with the prior art 1-2, the toothpaste of the examples 1-5 generally has better treatment effect on gingival bleeding, wherein the toothpaste of the example 5 has better effect on oral gingival inflammation than the toothpaste of other examples. While the prior arts 1 and 2 are common in the market for diminishing inflammation and stopping bleeding, the treatment effect of the embodiment of the invention on gingival bleeding cannot be achieved.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and substitutions can be made without departing from the technical principle of the present invention, and these modifications and substitutions should also be regarded as the protection scope of the present invention.
Claims (10)
1. The toothpaste composition for diminishing inflammation and stopping bleeding is characterized by being prepared from the following components in percentage by weight:
2. the anti-inflammatory hemostatic toothpaste composition according to claim 1,
the composition is prepared from the following components in percentage by weight:
3. the anti-inflammatory hemostatic toothpaste composition according to claim 2, wherein:
the composition is prepared from the following components in percentage by weight:
4. the anti-inflammatory hemostatic toothpaste composition according to claim 3, wherein:
the PEG-400 is purchased from Jinan crystal Hao chemical Co., Ltd, and the model number is TS 7;
the sodium carboxymethylcellulose is purchased from Jinan crystal Hao chemical company Limited and has the model number TH 9.
5. The anti-inflammatory hemostatic toothpaste composition according to claim 3, wherein:
the thickening silica is purchased from Guangzhou Highl New Material Co., Ltd, and the model number of the thickening silica is 10# -2 #;
the clean silicon dioxide is purchased from Guangzhou Highl New Material Co., Ltd, and the model number of the clean silicon dioxide is 10# -1 #.
6. The anti-inflammatory hemostatic toothpaste composition according to claim 3, wherein:
the essence is purchased from Chengdu Vientis Hongrun Biotechnology Co., Ltd, and has the model number DJ-4345;
the pigment is purchased from Zhengzhou Hengren chemotherapeutics products Co., Ltd, and the model number is SC 20141072100199.
7. The anti-inflammatory hemostatic toothpaste composition according to claim 3, wherein:
the traditional Chinese medicine composition comprises a lophatherum gracile extract, a chrysanthemum morifolium extract, dipotassium glycyrrhizinate, menthol and paeonol, wherein the lophatherum gracile extract and the chrysanthemum morifolium extract are purchased from Guangzhou YueChuang industries, Inc., and the dosage ratio of the lophatherum gracile extract, the chrysanthemum morifolium extract, the dipotassium glycyrrhizinate, the menthol and the paeonol is (0.1-1): (0.01-0.5): (0.01-0.5): (0.1-1): (0.01-0.5).
8. The preparation method of the toothpaste composition for diminishing inflammation and stopping bleeding is characterized by comprising the following steps:
the method comprises the following steps:
(1) adding sorbitol and PEG-400 into a paste making machine according to the formula amount; simultaneously reserving sorbitol for washing the water-phase premixing pot;
(2) weighing water according to the formula amount, adding saccharin sodium, tetrasodium pyrophosphate and sodium benzoate according to the formula amount into a premixing tank, stirring for 15 minutes, stopping stirring, observing whether the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved, and continuously stirring until the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved if the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are not dissolved; wherein the vacuum degree is controlled to be-0.04 MPa to-0.08 MPa and then the mixture enters a paste making machine;
(3) adding thickening type silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, sodium dodecyl sulfate and clean type silicon dioxide into a powder premixing and stirring pot according to the formula amount, and stirring for 5 minutes;
(4) controlling the vacuum degree to be-0.04 Mpa to-0.08 Mpa, sucking the powder obtained in the step (3) into a paste making machine, simultaneously opening double stirring blades and stirring for 15 minutes;
(5) weighing the traditional Chinese medicine composition, the essence and the pigment according to the formula, opening a fragrance inlet valve, sucking the substances, closing the fragrance inlet valve, starting a vacuum pump, stirring for 15 minutes, stopping stirring, starting the vacuum pump, and continuing stirring by a scraper for 10 minutes, wherein the vacuum degree is not lower than-0.096 Mpa before ointment discharge;
(6) stopping the scraper, slowly opening an air release valve, recovering the normal pressure, and sampling and inspecting;
(7) and (5) obtaining paste after the detection is qualified.
9. The method for preparing an anti-inflammatory hemostatic toothpaste composition according to claim 8, wherein:
adding sodium monofluorophosphate according to the formula amount, wherein the amount of the sodium monofluorophosphate is 2 times of the amount of the sodium benzoate;
the step (3) also comprises the following components: zinc citrate, probiotic particles and titanium dioxide, wherein the dosage ratio of the zinc citrate to the probiotic particles to the titanium dioxide is 5: 1: 2; wherein the dosage of the probiotic particles is 1.5 times of the dosage of the sodium dodecyl sulfate; wherein the probiotic particles are purchased from Guangzhou Yuejiao industries, Inc.
10. The method for preparing an anti-inflammatory hemostatic toothpaste composition according to claim 8, wherein:
and (5) weighing sodium lauroyl sarcosine according to the formula amount, wherein the dosage of the sodium lauroyl sarcosine is 3 times of that of the essence.
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