CN115040582A - Traditional Chinese medicine gingival-protecting oral care product containing radix zanthoxyli extract - Google Patents

Traditional Chinese medicine gingival-protecting oral care product containing radix zanthoxyli extract Download PDF

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CN115040582A
CN115040582A CN202210715904.7A CN202210715904A CN115040582A CN 115040582 A CN115040582 A CN 115040582A CN 202210715904 A CN202210715904 A CN 202210715904A CN 115040582 A CN115040582 A CN 115040582A
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extract
chinese medicine
traditional chinese
oral care
care product
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CN115040582B (en
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黄晓燕
李江平
唐红艳
王小敏
许逊
黄光伟
梁雪松
黄静
李月菲
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LIUZHOU LMZ CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Abstract

The invention provides a traditional Chinese medicine gingival protection oral care product containing radix zanthoxyli extracts, which contains traditional Chinese medicine active ingredients, wherein the traditional Chinese medicine active ingredients comprise 0.1-10% of the radix zanthoxyli extracts, 0.01-5% of naringin and 0.01-8% of the clinopodium extracts in percentage by weight. According to the oral care product, the radix zanthoxyli extract, the naringin and the clinopodium polycephalum extract in a specific ratio are added into the oral care product, and the components are mutually cooperated, so that the effects of bacteriostasis, hemostasis and the like can be achieved, dental plaque can be effectively inhibited, and discomfort conditions such as redness and swelling of gum, bleeding of gum and the like can be relieved.

Description

Traditional Chinese medicine gingival-protecting oral care product containing radix zanthoxyli extract
Technical Field
The invention relates to the technical field of oral care products, in particular to a traditional Chinese medicine gum-protecting oral care product.
Background
Dental caries, dentin hypersensitiveness, gingivitis, gingival red and swollen, gingival bleeding, periodontitis, halitosis, oral ulcer, toothache and the like are common oral diseases. The first two of which are related to the teeth, and the remainder to the gingiva. Gingivitis, the early stage of gum disease, is caused primarily by plaque (a sticky substance composed of bacteria, saliva and food debris) that accumulates on the teeth and manifests itself as redness and swelling of the gums and bleeding during brushing, and if properly treated, with proper oral care products, restores oral hygiene and the gums can restore their health.
In recent years, plant extract products having functionality have been favored under the influence of environmental protection, safety and return to nature. The oral care product is an indispensable product in daily life of people, and has the advantages of keeping oral hygiene and fresh breath, inhibiting and reducing oral bacteria, relieving gum problems and the like by paying more attention to safety and effective efficacy in addition to the cleaning function.
The plant extract is added into the oral care product as an effective component, has the characteristics of wide resources, small toxic and side effects and difficult generation of drug resistance, and has good curative effects of effectively inhibiting dental plaque, relieving swelling and bleeding gums and the like. The research on an oral care product which takes plant extracts as functional components and protects the health of gingiva is very meaningful for the oral hygiene of people.
Disclosure of Invention
The invention provides a traditional Chinese medicine gingival protection oral care product containing radix zanthoxyli extracts, wherein the radix zanthoxyli extracts, naringin and clinopodium polycephalum extracts in specific proportions are added into the oral care product, and the components are mutually synergistic, so that the effects of bacteriostasis, hemostasis and the like can be achieved, dental plaque can be effectively inhibited, and uncomfortable conditions such as gingival swelling, gingival bleeding and the like can be relieved.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a traditional Chinese medicine gingival protection and oral care product containing a radix zanthoxyli extract is characterized in that:
the oral care product contains traditional Chinese medicine active ingredients, wherein the traditional Chinese medicine active ingredients comprise 0.1-10% of radix zanthoxyli extract, 0.01-5% of naringin and 0.01-8% of clinopodium polycephalum extract in percentage by weight.
Preferably, the content of the radix zanthoxyli extract is 0.1-2.0%.
Preferably, the content of the naringin extract is 0.02-1.0%.
Preferably, the content of the clinopodium polycephalum extract is 0.05-5.0%.
Preferably, the radix zanthoxyli extract, the naringin and the clinopodium polycephalum extract are all ethanol extracts.
More preferably, the radix zanthoxyli extract and the clinopodium polycephalum extract are obtained by extracting raw medicines with ethanol, concentrating, and respectively obtaining the weight of the corresponding extracts and the mass ratio of the raw medicines at 0.5-2: 1. More preferably, the ethanol is ethanol with a volume fraction of 50-95%.
Preferably, the naringin is obtained by extracting the original drug with ethanol, concentrating, purifying and vacuum drying. More preferably, the ethanol is ethanol with a volume fraction of 50-95%.
Preferably, the purity of the naringin is more than or equal to 98 percent.
Preferably, the oral care product is a toothpaste, a mouthwash, a tooth powder, an oral spray, a mouth rinse, or a chewing gum.
Radix Zanthoxyli is dry root of Zanthoxylum nitidum (Roxb.) DC. of Rutaceae, and has bitter and pungent taste and mild property. Has effects of promoting blood circulation for removing blood stasis, activating qi-flowing, relieving pain, dispelling pathogenic wind, dredging collaterals, removing toxic substance and detumescence, and can be used for treating traumatic injury, stomach ache, toothache, rheumatalgia, etc.
Naringin is a dihydroflavonoid compound, and has antiinflammatory, analgesic, antiviral, antibacterial, antiallergic, antiulcer, and topical microcirculation and nutrition supply improving effects.
Herba Clinopodii refers to dry aerial parts of Clinopodium polycephalum C.Y.Wu et Hsuan or Clinopodium chinensis Q.Kuntze of Labiatae, and is bitter, astringent and cool. Blood cooling and hemostasis, and can be used for metrorrhagia and metrostaxis, hematuria, epistaxis, gingival hemorrhage, and traumatic hemorrhage; bleeding of uterine fibroids, etc.
The invention focuses on solving the problem of gum, and not only can relieve symptoms of gum inflammation, bleeding and the like, but also can inhibit oral bacteria and safely and effectively prevent the gum problem of the oral cavity through multiple effects of the radix zanthoxyli extract, the naringin and the clinopodium herb extract.
The radix zanthoxyli extract, the naringin and the clinopodium polycephalum extract in specific proportions are added into the oral care product, pharmacological tests prove that the components are mutually synergistic, the oral care product has stronger bacteriostatic effect on staphylococcus aureus and candida albicans, has stronger inhibiting effect on biological cell growth curves of porphyromonas gingivalis and streptococcus mutans, has obvious anti-inflammatory and hemostatic effects, and has positive effects on protecting the health of gingiva and maintaining the oral hygiene.
Drawings
FIG. 1 is a graph of the growth of Porphyromonas gingivalis.
FIG. 2 is a graph of growth of Streptococcus mutans.
Detailed Description
The present invention is further illustrated by the following specific examples, but the scope of the present invention is not limited to the following examples.
The radix zanthoxyli extract and the clinopodium polycephalum extract adopted in the embodiment are respectively prepared by heating and refluxing radix zanthoxyli and clinopodium polycephalum extract and 75% vol ethanol according to the weight ratio of 1:5, and the extract is concentrated to the mass ratio of 1:1 to the original medicine.
The naringin is prepared by reflux extraction of original drug and 95% vol ethanol at a weight ratio of 1:20 at a temperature of less than or equal to 50 ℃, concentration and purification of filtrate, and vacuum drying to obtain naringin with purity of more than or equal to 98%.
When preparing oral care products, radix Zanthoxyli extract, naringin, and herba Clinopodii extract are added as effective components with antibacterial, antiinflammatory, and hemostatic effects.
A Chinese medicinal oral care product containing radix Zanthoxyli extract, naringin, and herba Clinopodii extract for protecting gingiva and oral cavity (prepared in toothpaste for example)
The toothpaste in examples 1 to 5 comprises the following raw materials in percentage by weight as shown in table 1:
TABLE 1 traditional Chinese medicine gingival protecting toothpaste containing radix Zanthoxyli extract, naringin, and herba Clinopodii extract
Figure BDA0003709478230000041
Second, the traditional Chinese medicine gingival protecting toothpaste containing the radix zanthoxyli extract, the naringin and the clinopodium herb extract has the hemostatic effect
Taking 30 healthy New Zealand rabbits per group, weighing 2.0-2.5 kg, and being used for both males and females. Slowly injecting the 3% sodium pentobarbital 30mg/kg of ear vein, anesthetizing the rabbit, supinely fixing the rabbit on an operating table, cutting the middle of the abdomen to be about 6-8 cm long, exposing and fixing the liver, cutting the left lobe of the liver by a surgical scissors to cut the liver tissue to be about 1cm long, about 1cm wide and about 1cm high, and bleeding the wound surface in a jet-type manner. After the sprayed blood is wiped off, 1g of a sample to be tested is immediately coated on the part of the wound surface, gauze is covered, a weight of 200g is used for compressing for 1min, the weight is removed after 1min, the hemostasis effect is observed, bleeding does not occur, if bleeding still occurs, the sample to be tested is coated and then is continuously pressurized, the observation is carried out once every 30s, the hemostasis time is recorded, if bleeding still occurs after exceeding 3min, the hemostasis time is recorded as the hemostasis failure, and the hemostasis time is recorded as more than 3 min. After each sample test, the residual test substance is washed away by physiological saline at 37 ℃ so that the wound surface bleeds again, and then the next test substance sample is tested. Four tests of hemostasis test of liver local wound injury are carried out on each rabbit, and each test sample is applied according to the Latin prescription procedure, so that the influence of incision difference and medication sequence of liver local wound injury is reduced. The hemostatic experiment of the rabbit liver local wound injury bleeding is carried out for 20 times in total for each test object sample. The hemostatic effect is marked as F by the reciprocal score method (10/T), hemostasis is not achieved for more than 3min, and no F score is marked as 0. The results are shown in Table 2.
TABLE 2 hemostatic effect of traditional Chinese medicine gingival toothpaste containing radix Zanthoxyli extract, naringin, and herba Clinopodii extract on rabbit liver local wound injury hemorrhage
Figure BDA0003709478230000051
Figure BDA0003709478230000052
Figure BDA0003709478230000061
Note: comparison with starch group: p is less than 0.05, P is less than 0.01, P is less than 0.001, and P is greater than 0.05.
Comparison with toothpaste blank matrix group: p < 0.05, P < 0.01, P < 0.001, Δ P > 0.05.
HY-1 was found to be example 1, HY-2 was found to be example 2, HY-3 was found to be example 3, HY-4 was found to be example 4, and HY-5 was found to be example 5.
Experimental results show that toothpaste HY-3 group, toothpaste HY-4 group, toothpaste HY-5 group and Yunnan Baiyao all have obvious hemostatic effect on rabbit liver local wound injury bleeding and have obvious hemostatic effect.
Third, the Chinese medicine gingival protecting toothpaste containing the radix zanthoxyli extract, the naringin and the clinopodium herb extract has the bacteriostasis effect
Caries and periodontal disease are the two most common types of diseases of the oral cavity, and plaque is the initiating factor for both diseases. The pathogenic bacteria causing dental caries are streptococcus mutans which destroy hard tissues of teeth through adhesion, acid production, acid resistance and the like, thereby causing dental caries; porphyromonas gingivalis is one of the most important pathogenic bacteria of periodontal disease, and is an important member of the red complex closely related to periodontitis.
1. Experiment for inhibiting bacteria
(1) Aerobic bacteria inhibition experiment: and (4) carrying out a bacteriostatic effect test according to QBT 2738-2012 evaluation method of antibacterial and bacteriostatic effects of daily chemical products. Under the condition of 20-21 ℃, the experimental concentration of the toothpaste is 1:1, the acting time is 2min, and the experimental strains are 2 strains of staphylococcus aureus (ATCC 6538) and candida albicans (ATCC 10231); when the bacteriostasis rate is more than or equal to 50 percent, marking that the bacteriostasis effect is achieved, and repeating for three times; when the bacteriostasis rate is more than or equal to 90 percent, the mark shows that the bacteriostatic effect is stronger, and the process is repeated for three times. The results are shown in tables 3, 4 and 5.
(2) Anaerobic bacteria bacteriostasis experiment: and (4) carrying out bacteriostatic effect test by adopting a biological growth curve monitoring method. Preparing a bacteria culture solution by using the effective content value of the extracted composition in the toothpaste as a test group; the bacteria culture solution without the components of the extract composition is used as a control group, and the OD value is measured once by using an ultraviolet spectrophotometer at 35-37 ℃ under anaerobic conditions at intervals of 1 hour to represent the concentration and growth condition of the bacteria to be tested. Wherein the measurement wavelength of Porphyromonas gingivalis (ATCC 33277) is 450nm, and the measurement wavelength of Streptococcus mutans (ATCC 25175) is 600 nm. The biological growth curve of the sample group is lower than that of the control group, and the mark shows that the biological growth curve of the sample group has an inhibition effect on the growth of bacteria at the concentration, and has an antibacterial effect. The results are shown in Table 6.
2. The tests carried out using examples 1, 2 and 3, the blank control did not contain the above-mentioned extraction composition.
TABLE 3 aerobic bacteria inhibition test results of the traditional Chinese medicine gingival crevicular protection toothpaste containing radix zanthoxyli extract, naringin and clinopodium polycephalum extract (example 1)
Figure BDA0003709478230000071
TABLE 4 aerobic bacteria inhibition test results of the traditional Chinese medicine gingival crevicular protection toothpaste containing radix zanthoxyli extract, naringin and clinopodium polycephalum extract (example 2)
Figure BDA0003709478230000072
TABLE 5 aerobic bacteriostatic test results of multiple gingival crevicular toothpaste containing radix Zanthoxyli extract, naringin, herba Clinopodii extract (example 3)
Figure BDA0003709478230000081
TABLE 6 results of anaerobic bacteria test of multiple gingival protection toothpaste containing radix Zanthoxyli extract, naringin, and Clinopodium polycephalum herba Clinopodii extract (examples 1, 2, 3)
Figure BDA0003709478230000082
The results of bacteriostasis tests show that, as shown in fig. 1 and 2, the bacteriostasis rates of examples 1 and 2 on staphylococcus aureus and candida albicans are greater than 70%, and the bacteriostasis effect is achieved. In example 1, the content of the extract composition had a certain inhibitory effect on the growth curve of the biological cells of Porphyromonas gingivalis and Streptococcus mutans.
Example 3 has a bacteriostatic rate of more than 90% for staphylococcus aureus and candida albicans, and has a strong bacteriostatic effect. In example 3, the content of the extract composition has a strong inhibitory effect on the growth curve of the biological cells of Porphyromonas gingivalis and Streptococcus mutans, and can reduce the propagation rate and the growth time.
Fourthly, the anti-inflammatory effect of the traditional Chinese medicine gingival protection toothpaste containing the radix zanthoxyli extract, the naringin and the clinopodium polycephalum extract
Selecting 60 healthy Kunming female mice with the weight of 18-22 g, and dividing 7 groups of the mice into 10 groups at random. Blank control group (physiological saline 0.1 ml/piece), toothpaste blank matrix group (toothpaste blank matrix group 0.1 g/piece), fluocinonide emulsion group (fluocinonide emulsion 0.1 g/piece), toothpaste HY-1 group, toothpaste HY-2 group, toothpaste HY-3 group, toothpaste HY-4 group, and toothpaste HY-5 group. In the experiment, 0.1ml of dimethylbenzene is uniformly coated on the two sides of the auricle of the right ear of each animal in each group, and the left ear is not treated and is used as a blank control. After coating dimethylbenzene for 30min, each group of tested substance samples with the amount of 0.1 g/animal is respectively and uniformly coated on the inner surface and the outer surface of the right auricle of each animal. After the test object is given for 1h, the white mouse is dislocated and killed, two auricles are cut off, a sample of the test object on the right auricle is washed away by normal saline, a dry cotton ball is used for wiping off, the two auricles are overlapped, two round lugs are chiseled on the same part by a puncher with the inner diameter of 8mm, the round lugs are respectively weighed on an FA1004 type electronic analytical balance, the weight of the right lug minus the weight of the left lug is a swelling value, and the data are subjected to statistical t test. The results are shown in Table 6.
TABLE 6 influence of traditional Chinese medicine gingival protecting toothpaste containing radix Zanthoxyli extract, naringin, and herba Clinopodii extract on acute inflammation swelling of auricle of mice caused by xylene
Figure BDA0003709478230000091
Figure BDA0003709478230000092
Figure BDA0003709478230000101
Note: comparison with blank control: p is less than 0.05, P is less than 0.01, P is less than 0.001, and P is greater than 0.05.
Comparison with toothpaste blank matrix group: p < 0.05, P < 0.01, P < 0.001, Δ P > 0.05.
HY-1 was found to be example 1, HY-2 was found to be example 2, HY-3 was found to be example 3, HY-4 was found to be example 4, and HY-5 was found to be example 5.
Experimental results show that toothpaste HY-3 group, toothpaste HY-4 group, toothpaste HY-5 group and fluocinonide cream group can remarkably reduce the weight of auricle with acute inflammation and swelling of mice, obviously inhibit acute inflammation and swelling of auricle of mice caused by xylene, and have obvious anti-inflammatory effect on acute inflammation. The toothpaste HY-1 group and the toothpaste HY-2 group have no obvious effect on reducing the weight of auricles of acute inflammation swelling of mice, have no obvious effect on inhibiting acute inflammation swelling of auricles of mice caused by xylene, and have no obvious anti-inflammatory effect on acute inflammation.

Claims (6)

1. A traditional Chinese medicine gingival protection and oral care product containing a radix zanthoxyli extract is characterized in that:
the oral care product contains traditional Chinese medicine active ingredients, wherein the traditional Chinese medicine active ingredients comprise 0.1-10% of radix zanthoxyli extract, 0.01-5% of naringin and 0.01-8% of clinopodium polycephalum extract in percentage by weight.
2. The traditional Chinese medicine gum-protecting oral care product as claimed in claim 1, wherein:
the content of the radix zanthoxyli extract is 0.1-2.0%.
3. The traditional Chinese medicine gum-protecting oral care product as claimed in claim 1, wherein:
the content of the naringin extract is 0.02-1.0%.
4. The traditional Chinese medicine gum-protecting oral care product as claimed in claim 1, wherein:
the content of the clinopodium polycephalum extract is 0.05-5.0%.
5. The traditional Chinese medicine gum-protecting oral care product as claimed in claim 1, wherein:
the radix zanthoxyli extract, the naringin and the clinopodium polycephalum extract are all ethanol extracts.
6. The traditional Chinese medicine gum-protecting oral care product as claimed in claim 1, wherein:
the oral care product is toothpaste, mouthwash, tooth powder, oral spray, mouth rinse or chewing gum.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101244016A (en) * 2008-03-17 2008-08-20 柳州两面针股份有限公司 Application of aurantiin in preparing oral cavity nursing health products
CN106491454A (en) * 2016-12-15 2017-03-15 柳州两面针股份有限公司 Chinese medicinal toothpaste

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101244016A (en) * 2008-03-17 2008-08-20 柳州两面针股份有限公司 Application of aurantiin in preparing oral cavity nursing health products
CN106491454A (en) * 2016-12-15 2017-03-15 柳州两面针股份有限公司 Chinese medicinal toothpaste

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
覃青云等: "柚皮苷在口腔护理用品中的应用研究" *

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