CN102727407B - Health-care toothpaste containing Chinese prickly ash extracts - Google Patents
Health-care toothpaste containing Chinese prickly ash extracts Download PDFInfo
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- CN102727407B CN102727407B CN2012100926896A CN201210092689A CN102727407B CN 102727407 B CN102727407 B CN 102727407B CN 2012100926896 A CN2012100926896 A CN 2012100926896A CN 201210092689 A CN201210092689 A CN 201210092689A CN 102727407 B CN102727407 B CN 102727407B
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Abstract
The invention, relating to the field of chemicals for daily use, especially relates to an application of Chinese prickly ash extracts in toothpaste. The invention further discloses health-care toothpaste and a health-care toothpaste additive. The health-care toothpaste comprises 0.1-3.5 wt% of Chinese prickly ash extracts containing no less than 30 wt% of extracts of volatile oil from Chinese prickly ash. The toothpaste additive comprises 0.1-3.5 weight parts of Chinese prickly ash extracts, and 0.1-2.5 weight parts of eugenol. According to the invention, the health-care toothpaste containing Chinese prickly ash extracts of the invention adopts Chinese prickly ash extracts and eugenol which have antibacterial action and analgesia action, thus the toothpaste has no toxicity and no side effect to human's bodies, and the safety of the toothpaste is greatly better than synthetic antibacterial agents; the synergistic effect of Chinese prickly ash extracts and eugenol can enhance the antimicrobial antibacterial functions, and the purposes of diminishing inflammation, easing pain, removing halitosis, improving gingivitis and oral ulcer, cleaning oral cavity and carrying out oral health are achieved.
Description
Technical field
The present invention relates to filed of daily-use chemical industry, relate in particular to a kind of pepper Healthy toothpaste.
Background technology
Toothpaste is dental care products essential in daily life.Its major function is cleaning oral cavity, after use, gives salubrious comfortable implication.In recent years, along with improving constantly of consumer oral cavity health consciousness, and natural, green, the enhancing of safe consumption theory, people proposed more requirement to toothpaste, and various medicated toothpaste with health care emerge in large numbers on market.Although existing Chinese herbal toothpaste has certain inhibition oral cavity noxious bacteria, fresh breath, take care of one's teeth, prevent and treat the function such as oral disease, because the medicinal herb components that uses is more single, the tooth protection health-care effect is not ideal enough.Although and add the medicated toothpaste successful of chemicals, there is the safety issue to human body in life-time service.At present, on market also rarely seen employing natural plant extracts aspect the curative-effect health-care of oral cavity, reaching the health-care toothpaste of produce effects.
Pericarpium Zanthoxyli is the spice of commonly using, and is also the Chinese medicine that a kind of medical value is very high, and it is warm in nature, and acrid in the mouth has warming spleen and stomach for dispelling cold, the effect of antibiotic, dehumidifying, analgesia, parasite killing etc.The traditional Chinese medical science is used for the treatment of vomiting, anemofrigid-damp arthralgia, the diseases such as toothache.Compendium of Material Medica record: " the hard tooth of Pericarpium Zanthoxyli, black hair, improving eyesight, clothes for a long time, good color, anti-old, increase year, strong god." Pericarpium Zanthoxyli mainly contains the number of chemical compositions such as volatile oil, alkaloid, modern medicine proves, Pericarpium Zanthoxyli can strengthen the human body immunity, can strengthen the sterilizing power of neutrophilic leukocyte, and can strengthen the phagocytic function of macrophage; Fructus Zanthoxyli extract has the pharmacological actions such as anesthesia, pain relieving, antibiotic, antitumor, anthelmintic.Experiment shows, Fructus Zanthoxyli extract all has and significantly kills and inhibitory action various pathogenic bacterium.The spicy component of Pericarpium Zanthoxyli also has very strong persistence analgesic activity.Utilize the antibiotic and analgesic properties of Fructus Zanthoxyli extract, assistant is joined the eugenol natural antibacterial agent that derives from plant of clove, and the exploitation health-care toothpaste, be expected to the effect that reaches desirable, the demand of its efficient, natural safe characteristic conforms modern consumer.This type of research at present and product are not reported in all kinds of documents.
Summary of the invention
The object of the present invention is to provide a kind of new application of Fructus Zanthoxyli extract, this preparation that is applied as toothpaste provides new approaches.
For achieving the above object, technical scheme of the present invention is:
The application of Fructus Zanthoxyli extract in preparing health-care toothpaste, described Fructus Zanthoxyli extract refer to from the extract that contains Pericarpium Zanthoxyli volatile oil that extracts Pericarpium Zanthoxyli.
Further, described Fructus Zanthoxyli extract refers to from the extract that contains Pericarpium Zanthoxyli volatile oil and fiber crops element that extracts Pericarpium Zanthoxyli.
Further, described Fructus Zanthoxyli extract refers to Pericarpium Zanthoxyli removal cellulose and lignin residue afterwards.
Two of purpose of the present invention is to provide a kind of health-care toothpaste and toothpaste additive, and it has significant analgesic activity; Described toothpaste additive has anti-inflammatory analgesic, antihalitosis, improves the effect of gingivitis and oral ulcer.
For achieving the above object, technical scheme of the present invention is:
The health-care toothpaste that contains Fructus Zanthoxyli extract, contain the Fructus Zanthoxyli extract that mass fraction is 0.1-3.5% in described health-care toothpaste, described Fructus Zanthoxyli extract is to contain the extract that mass fraction is no less than 30% Pericarpium Zanthoxyli volatile oil.
Further, in described health-care toothpaste, contain the Fructus Zanthoxyli extract of mass fraction 1.0%, it is that 36% Pericarpium Zanthoxyli volatile oil and mass fraction are 6% fiber crops element that described Fructus Zanthoxyli extract contains mass fraction.
Further, described Fructus Zanthoxyli extract obtains by the following method: Pericarpium Zanthoxyli is pulverized, insert extraction kettle, with the 350-450L/h flow velocity, pass into supercritical carbon dioxide, in temperature, be that 35-50 ℃, pressure are to extract under the 25-30MPa condition, extraction time 1.5-2.5 hour, emit extract from knockout drum, and described extract is Fructus Zanthoxyli extract.
Further, described health-care toothpaste is composed of the following components by mass parts: Fructus Zanthoxyli extract 0.1-3.5 part, eugenol 0.1-2.5 part, calcium carbonate 40-50 part, sorbitol 15-25 part, silicon dioxide 3-7 part, glycerol 3-6 part, sodium carboxymethyl cellulose 0.2-1.5 part, xanthan gum 0.2-0.5 part, sodium laurylsulfate 1.5-2.5 part, polyoxyethylene (20) sorbitan mono-oleic acid ester 0.5-1.5 part, essence 0.3-1.0 part, saccharin sodium 0.1-0.2 part, deionized water 15-30 part.
Further, described health-care toothpaste, composed of the following components by mass parts: 1.5 parts of Fructus Zanthoxyli extracts, 1.5 parts of eugenol, 40 parts of calcium carbonate, 15 parts of sorbitol, 4 parts of silicon dioxide, 3 parts of glycerol, 1.0 parts of sodium carboxymethyl cellulose, 0.3 part of xanthan gum, 2.5 parts of sodium laurylsulfates, 1.0 parts of polyoxyethylene (20) sorbitan mono-oleic acid esters, 0.3 part, essence, 0.15 part of saccharin sodium, 30 parts of deionized waters.
Contain the toothpaste additive of Fructus Zanthoxyli extract, composed of the following components by mass parts:
Fructus Zanthoxyli extract 0.1-3.5 part, eugenol 0.1-2.5 part, described Fructus Zanthoxyli extract refers to from the extract that contains Pericarpium Zanthoxyli volatile oil and fiber crops elements that extracts Pericarpium Zanthoxyli, in described Fructus Zanthoxyli extract, contains mass fraction and is no less than 30% Pericarpium Zanthoxyli volatile oil and mass fraction and is no less than 5% fiber crops element.
Further, toothpaste additive is composed of the following components by mass parts:
1.0 parts of Fructus Zanthoxyli extracts, 0.5 part of eugenol; Described Fructus Zanthoxyli extract obtains as follows: described Fructus Zanthoxyli extract is to obtain by the following method: Pericarpium Zanthoxyli is pulverized, insert extraction kettle, with the 350-450L/h flow velocity, pass into supercritical carbon dioxide, in temperature, be that 35-50 ℃, pressure are to extract under the 25-30MPa condition, extraction time 1.5-2.5 hour, from knockout drum, emit extract, described extract is Fructus Zanthoxyli extract.
Beneficial effect of the present invention is: in pepper Healthy toothpaste of the present invention, used antibiotic and Fructus Zanthoxyli extract and eugenol analgesic activity.Modern study proves, Fructus Zanthoxyli extract has the pharmacological actions such as anesthesia, pain relieving, antibiotic, antitumor, anthelmintic.As natural antibacterial agent, anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus albus, bacillus subtilis, escherichia coli, dysentery bar flute, Bacillus proteus, bacillus pyocyaneus, vibrio cholera etc. are all had and significantly kill and inhibitory action.The spicy component of Fructus Zanthoxyli extract has very strong persistence analgesic activity, aspect treatment toothache, dental caries, good synergism is being arranged.Eugenol is the natural antibacterial agent that derives from plant of clove, has very strong sterilizing power, and is harmless to human-body safety.Eugenol has the effects such as analgesia anesthesia, antibacterial bacteriostatic, antioxidation, analgesic, antitumor, promotion Transdermal absorption.Experiment shows, the various pathogens such as the anaerobe of eugenol boil on the nape opposite the mouth Intracavity, escherichia coli, staphylococcus aureus, streptococcus, dysentery bacterium, tubercule bacillus all have sterilization and fungistatic effect preferably.These two kinds of antibacterial be all edible, to the pure natural antibacterial agent of human body without any toxic and side effects, safety is better than synthetic antibacterial agents greatly.Toothpaste of the present invention is by two kinds of composite uses of natural agents, and its cooperative effect can strengthen the antibacterial bacteriostatic ability of toothpaste, reaches anti-inflammatory analgesic, antihalitosis, improves gingivitis, oral ulcer, the purpose of cleaning and health care that oral cavity is carried out.This preparation method technique is simple, produces easy to controlly, is suitable for suitability for industrialized production.
The specific embodiment
In order to make the purpose, technical solutions and advantages of the present invention clearer, below the preferred embodiments of the present invention are described in detail.
The extraction of embodiment 1 Fructus Zanthoxyli extract
The 12000g dry Pericarpium Zanthoxyli being pulverized, inserted extraction kettle, with the 430L/h flow velocity, pass into supercritical carbon dioxide, is that 50 ℃, pressure are to extract under the 25MPa condition in temperature, and extraction time 2h, emit extract from knockout drum, obtains the 996g Fructus Zanthoxyli extract.It is that 36% Pericarpium Zanthoxyli volatile oil and mass fraction are 6% fiber crops element that described Fructus Zanthoxyli extract contains mass fraction.
Except with said method, extracting, steam distillation, vegetable oil extraction, edible ethanol extraction method, dehydrated alcohol extraction method or the supercritical carbon dioxide extraction method that also can adopt the people such as monarch Meng Qing to mention in " impact of Different Extraction Method on Fructus Zanthoxyli extract extraction ratio and quality " obtain Fructus Zanthoxyli extract; Adopt diverse ways, in the Fructus Zanthoxyli extract of acquisition, the yield difference of Pericarpium Zanthoxyli volatile oil.In the present invention, no matter adopt which kind of method, purpose all is to obtain Fructus Zanthoxyli extract.Wide in range understanding, described Fructus Zanthoxyli extract refer to from the extract that contains Pericarpium Zanthoxyli volatile oil that extracts Pericarpium Zanthoxyli.Further limit, described Fructus Zanthoxyli extract refers to from the extract that contains Pericarpium Zanthoxyli volatile oil and fiber crops element that extracts Pericarpium Zanthoxyli.Further limit, described Fructus Zanthoxyli extract refers to the residue after Pericarpium Zanthoxyli removal cellulose and lignin again.The quality of the Pericarpium Zanthoxyli volatile oil that contains in described Fructus Zanthoxyli extract is at least 30% of described Fructus Zanthoxyli extract.In Pericarpium Zanthoxyli volatile oil, contain any one or more material in linalool, limonene, sabinene, ocimene, myrcene, β-phellandrene, 1, 8-Cineole, ethyl dimethyl, linalyl butyrate, β-caryophyllene, 3 Methylbutanoic acid ethyl ester, germacrene, γ-terpinene, β-thujone, alpha-terpineol, nerolidol.
Through evidence, the Fructus Zanthoxyli extract that the present embodiment obtains has the pharmacological actions such as anesthesia, pain relieving, antibiotic, anthelmintic.As natural antibacterial agent, anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus albus, bacillus subtilis, escherichia coli, dysentery bar flute, Bacillus proteus, bacillus pyocyaneus, vibrio cholera etc. are all had and significantly kill and inhibitory action.The spicy component of Fructus Zanthoxyli extract (fiber crops element) has very strong persistence analgesic activity, aspect treatment toothache, dental caries, good synergism is being arranged.So Fructus Zanthoxyli extract can be used for preparing health-care toothpaste, this health-care toothpaste possesses pain relieving and antibiotic effect.The fiber crops element is amides compound, be the spicy component with intense stimulus from extracting Pericarpium Zanthoxyli, be one or more materials in α-sanshool, hydroxyl-alpha-sanshool, hydroxy-beta-sanshool, γ-sanshool, hydroxyl γ-sanshool, iso-hydroxyl-γ-sanshool, dehydrogenation-γ-sanshool, xanthoxlin, different xanthoxlin, two hydrogen xanthoxlin or tetrahydrochysene xanthoxlin.In Meng Yijuan " extracting method of numb-taste components and the industrialization of a Pericarpium Zanthoxyli " literary composition, the extracting method of fiber crops elements (being numb-taste components) comprises steam distillation, organic solvent extraction method and supercritical carbon dioxide extraction method.
The preparation of embodiment 2 health-care toothpastes
By mass parts, take 3.5 parts of Fructus Zanthoxyli extracts (it is that 36% Pericarpium Zanthoxyli volatile oil and mass fraction are 6% fiber crops element that described Fructus Zanthoxyli extract contains mass fraction), eugenol 0.1, carbonic acid Ca45, sorbitol 20, silicon dioxide 7, glycerol 6, sodium carboxymethyl cellulose 0.2, xanthan gum 0.5, sodium laurylsulfate 2.0, polyoxyethylene (20) sorbitan mono-oleic acid ester 0.5, essence 1.0, saccharin sodium 0.1, the deionized water 15 of embodiment 1 preparation.By described formula ratio, deionized water, sorbitol, glycerol, polyoxyethylene (20) sorbitan mono-oleic acid ester, saccharin sodium, sodium carboxymethyl cellulose, xanthan gum, sodium laurylsulfate are added in Manufacturing medicine extract machine to stirring and evenly mixing; Add calcium carbonate, silicon dioxide and described toothpaste additive (Fructus Zanthoxyli extract and eugenol), high-speed stirred, homogenizing; Then add essence, again carry out high-speed stirred, homogenizing, namely make lotion of toothpaste.
The preparation of embodiment 3 health-care toothpastes
By mass parts, take 0.1 part of Fructus Zanthoxyli extract (it is that 36% Pericarpium Zanthoxyli volatile oil and mass fraction are 6% fiber crops element that described Fructus Zanthoxyli extract contains mass fraction), 2.5 parts of eugenol, 50 parts of calcium carbonate, 25 parts of sorbitol, 3 parts of silicon dioxide, 5 parts of glycerol, 1.5 parts of sodium carboxymethyl cellulose, 0.2 part of xanthan gum, 1.5 parts of sodium laurylsulfates, 1.5 parts of polyoxyethylene (20) sorbitan mono-oleic acid esters, 0.5 part, essence, 0.2 part of saccharin sodium, 20 parts of the deionized waters of embodiment 1 preparation.By described formula ratio, deionized water, sorbitol, glycerol, polyoxyethylene (20) sorbitan mono-oleic acid ester, saccharin sodium, sodium carboxymethyl cellulose, xanthan gum, sodium laurylsulfate are added in Manufacturing medicine extract machine to stirring and evenly mixing; Add calcium carbonate, silicon dioxide and described toothpaste additive, high-speed stirred, homogenizing; Then add essence, again carry out high-speed stirred, homogenizing, namely make lotion of toothpaste.
The preparation of embodiment 4 health-care toothpastes
By mass parts, take 1.0 parts of Fructus Zanthoxyli extracts (it is that 36% Pericarpium Zanthoxyli volatile oil and mass fraction are 6% fiber crops element that described Fructus Zanthoxyli extract contains mass fraction), 0.5 part of eugenol, 42 parts of calcium carbonate, 16 parts of sorbitol, 4 parts of silicon dioxide, 4 parts of glycerol, 1.2 parts of sodium carboxymethyl cellulose, 0.3 part of xanthan gum, 2.4 parts of sodium laurylsulfates, 1.0 parts of polyoxyethylene (20) sorbitan mono-oleic acid esters, 0.4 part, essence, 0.15 part of saccharin sodium, 28 parts of the deionized waters of embodiment 1 preparation.By described formula ratio, deionized water, sorbitol, glycerol, polyoxyethylene (20) sorbitan mono-oleic acid ester, saccharin sodium, sodium carboxymethyl cellulose, xanthan gum, sodium laurylsulfate are added in Manufacturing medicine extract machine to stirring and evenly mixing; Add calcium carbonate, silicon dioxide and described toothpaste additive, high-speed stirred, homogenizing; Then add essence, again carry out high-speed stirred, homogenizing, namely make lotion of toothpaste.
The preparation of embodiment 5 health-care toothpastes
By mass parts, take 1.5 parts of Fructus Zanthoxyli extracts (it is that 36% Pericarpium Zanthoxyli volatile oil and mass fraction are 6% fiber crops element that described Fructus Zanthoxyli extract contains mass fraction), 1.5 parts of eugenol, 40 parts of calcium carbonate, 15 parts of sorbitol, 5 parts of silicon dioxide, 3 parts of glycerol, 1.0 parts of sodium carboxymethyl cellulose, 0.3 part of xanthan gum, 2.5 parts of sodium laurylsulfates, 1.0 parts of polyoxyethylene (20) sorbitan mono-oleic acid esters, 0.3 part, essence, 0.15 part of saccharin sodium, 30 parts of the deionized waters of embodiment 1 preparation.By described formula ratio, deionized water, sorbitol, glycerol, polyoxyethylene (20) sorbitan mono-oleic acid ester, saccharin sodium, sodium carboxymethyl cellulose, xanthan gum, sodium laurylsulfate are added in Manufacturing medicine extract machine to stirring and evenly mixing; Add calcium carbonate, silicon dioxide and described toothpaste additive, high-speed stirred, homogenizing; Then add essence, again carry out high-speed stirred, homogenizing, namely make lotion of toothpaste.
The antibacterial tests of embodiment 6 pepper Healthy toothpaste
1. bactericidal assay
Test organisms is staphylococcus aureus ATCC6538 strain, escherichia coli 8099 strains. white beads ATCC10231 strain.Adopt carrier quantitative germicidal test, test carrier is 10mm * 10mm slide, after pressuresteam sterilization, with dripping, dyes the method microbiological contamination.Every of bacterium drop dosage is 0.01ml, and every microbiological contamination amount is 5 * 10
5Cfu/ml-5 * 10
6Cfu/ml, after dripping microbiological contamination liquid. be placed in 37 ℃ of incubator inner drying 30min. for test.During test. bacterium sheet microbiological contamination face is covered in the health-care toothpaste of embodiment 5 preparations, after being applied to the scheduled time, take out the bacterium sheet, immigration contains in the conical flask of bead and 10ml nertralizer. and put on the Kang Shi oscillator and shake 2min (365 times/minute). get its stock solution or different dilution diluent 0.5ml, with tilt-pour process, make count plate.All test samples all are placed in 37 ℃ of incubators cultivates 48h, observes final result.
2. result of the test
Adopt the carrier test method to measure the killing action of toothpaste to staphylococcus aureus ATCC6538 strain, escherichia coli 8099 strains and Candida albicans ATCC10231 strain, toothpaste in 1min to the killing rate of staphylococcus aureus, escherichia coli and Candida albicans respectively 99.99%, 99.98% and 99.97%.3min all reaches 100%.
Embodiment 7 pepper Healthy toothpaste result of use tests
Select 80 experimenters to test.Choice criteria: select case by the conventional diagnostic criteria of assert of medical treatment.Subject age: 20 1 60 years old; Sex: 40 of men, 40 of female;
Using method: with the health-care toothpaste of embodiment 4 preparations, sooner or later respectively use once every day, each 3-5 minute, between the operating period, do not add and use other drug.Criterion of therapeutical effect: a, effect are remarkable: symptom disappears substantially; B, effective: symptom takes a turn for the better; C, invalid: without positive effect.Observation of curative effect result: observe 5-14 days, the results are shown in Table 1.
Table 1 toothpaste result on trial of the present invention
| Disease | Tested number | Produce effects | Effectively | Invalid | Effective percentage % |
| Toothache | 20 | 17 | 1 | 2 | 90 |
| Halitosis | 20 | 17 | 2 | 1 | 95 |
| Gingivitis | 20 | 14 | 3 | 3 | 85 |
| Oral ulcer | 20 | 15 | 3 | 2 | 90 |
Finally explanation is, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although with reference to preferred embodiment, the present invention is had been described in detail, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement technical scheme of the present invention, and not breaking away from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of claim scope of the present invention.
Claims (4)
1. contain the health-care toothpaste of Fructus Zanthoxyli extract, it is characterized in that, composed of the following components by mass parts: Fructus Zanthoxyli extract 0.1-3.5 part, eugenol 0.1-2.5 part, calcium carbonate 40-50 part, sorbitol 15-25 part, silicon dioxide 3-7 part, glycerol 3-6 part, sodium carboxymethyl cellulose 0.2-1.5 part, xanthan gum 0.2-0.5 part, sodium laurylsulfate 1.5-2.5 part, Tween 80 0.5-1.5 part, essence 0.3-1.0 part, saccharin sodium 0.1-0.2 part, deionized water 15-30 part; Described Fructus Zanthoxyli extract obtains by the following method: Pericarpium Zanthoxyli is pulverized, insert extraction kettle, with the 350-450L/h flow velocity, pass into supercritical carbon dioxide, in temperature, be that 35-50 ℃, pressure are to extract under the 25-30MPa condition, extraction time 1.5-2.5 hour, from knockout drum, emit extract, described extract is Fructus Zanthoxyli extract.
2. health-care toothpaste according to claim 1, it is characterized in that, composed of the following components by mass parts: 1.5 parts of Fructus Zanthoxyli extracts, 1.5 parts of eugenol, 40 parts of calcium carbonate, 15 parts of sorbitol, 4 parts of silicon dioxide, 3 parts of glycerol, 1.0 parts of sodium carboxymethyl cellulose, 0.3 part of xanthan gum, 2.5 parts of sodium laurylsulfates, 1.0 parts of Tween 80s, 0.3 part, essence, 0.15 part of saccharin sodium, 30 parts of deionized waters.
3. contain the toothpaste additive of Fructus Zanthoxyli extract, it is characterized in that, composed of the following components by mass parts:
Fructus Zanthoxyli extract 0.1-3.5 part, eugenol 0.1-2.5 part, described Fructus Zanthoxyli extract refers to from the extract that contains Pericarpium Zanthoxyli volatile oil and fiber crops elements that extracts Pericarpium Zanthoxyli, in described Fructus Zanthoxyli extract, contains mass fraction and is no less than 30% Pericarpium Zanthoxyli volatile oil and mass fraction and is no less than 5% fiber crops element.
4. toothpaste additive according to claim 3, is characterized in that, and is composed of the following components by mass parts:
1.0 parts of Fructus Zanthoxyli extracts, 0.5 part of eugenol; Described Fructus Zanthoxyli extract obtains by the following method: Pericarpium Zanthoxyli is pulverized, insert extraction kettle, with the 350-450L/h flow velocity, pass into supercritical carbon dioxide, in temperature, be that 35-50 ℃, pressure are to extract under the 25-30MPa condition, extraction time 1.5-2.5 hour, from knockout drum, emit extract, described extract is Fructus Zanthoxyli extract.
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| CN108635310B (en) * | 2018-08-14 | 2021-04-20 | 海南金香远药业科技有限公司 | Anti-inflammation toothpaste and preparation method thereof |
| CN109157424A (en) * | 2018-10-12 | 2019-01-08 | 赵孔发 | A kind of preparation method and applications of Japan pepper essential oil microcapsules |
| CN111434329A (en) * | 2019-01-11 | 2020-07-21 | 薪火炙药(北京)科技有限公司 | Antibacterial anti-inflammatory health-care toothpaste containing pepper extract |
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