CN113491647A - Zanthoxylum bungeanum pain-relieving and inflammation-diminishing toothpaste and preparation method thereof - Google Patents
Zanthoxylum bungeanum pain-relieving and inflammation-diminishing toothpaste and preparation method thereof Download PDFInfo
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Abstract
The invention discloses pricklyash peel and tsaoko amomum fruit pain-relieving and inflammation-diminishing toothpaste which comprises the following specific raw materials in parts by mass: 0.5-0.8% of pepper essential oil microcapsule, 0.2-0.5% of tsaoko essential oil microcapsule, 1-3% of adhesive, 22-65% of humectant, 1.5-1.8% of water-soluble additive, 20-50% of abrasive, 2-3% of foaming agent, 1-2% of essence, 1-1.5% of preservative and the balance of deionized water. The invention takes the pepper essential oil and the tsaoko essential oil as effective medicinal components, and other various auxiliary materials are added for mutual action to prepare the medicinal toothpaste with special effects of diminishing inflammation, resisting bacteria, preventing sensitivity, easing pain and the like; the effective essential oil components are prepared into microcapsules and then added into the toothpaste, so that the drug effect and the fragrance are kept without losing.
Description
Technical Field
The invention relates to the technical field of daily chemicals, and particularly relates to pricklyash peel pain-relieving and inflammation-diminishing toothpaste and a preparation method thereof.
Background
The toothpaste is a cleaning article commonly used in daily life, is a dentifrice, is smeared on a toothbrush, is used for cleaning teeth and keeping the teeth beautiful and bright white. The toothpaste has effects of rubbing, removing bacterial plaque, cleaning and polishing tooth surface, and refreshing oral cavity. The medicinal toothpaste is prepared by adding certain medicines on the basis of common toothpaste, and when the toothpaste reaches the surface of teeth or the environment around the teeth during tooth brushing, dental plaque is reduced through the action of the medicines, so that the effects of preventing dental caries and periodontal disease are achieved. The medicated toothpaste is very popular with people, and the promotion of the medicine with prevention efficacy or treatment efficacy by using the toothpaste is an ideal mode.
The existing toothpaste often has other chemical changes due to long-term storage time, loses the original drug effect, and the effective drugs are often not suitable for being placed in the toothpaste due to peculiar smell. Although the medicated toothpaste is a good idea, more intensive research is needed to really achieve the effect of preventing oral diseases. Therefore, the technical problem to be solved by the technical personnel in the field is to provide the toothpaste which has the effects of diminishing inflammation, resisting bacteria, preventing sensitivity, relieving pain and the like and can ensure that the efficacy of the effective medicament is not lost.
Disclosure of Invention
The invention provides the Zanthoxylum bungeanum pain-relieving and inflammation-diminishing toothpaste which can keep the drug effect of the drug for a long time;
in order to achieve the purpose, the invention adopts the following technical scheme: the fructus zanthoxyli toothpaste with the effects of relieving pain and diminishing inflammation comprises the following raw materials in percentage by mass: 0.5-0.8% of pepper essential oil microcapsule, 0.2-0.5% of tsaoko essential oil microcapsule, 1-3% of adhesive, 22-65% of humectant, 1.5-1.8% of water-soluble additive, 20-50% of abrasive, 2-3% of foaming agent, 1-2% of essence, 1-1.5% of preservative and the balance of deionized water.
Further, the adhesive is one or a mixture of more of sodium alginate, hydroxyethyl cellulose and Lota-type carrageen gum;
the humectant is one or more of glycerol, sorbitol, and xylitol.
Adopt above-mentioned further beneficial effect to lie in: the humectants such as glycerin, sorbitol and xylitol adopted by the invention have sweet taste and are often used as sweeteners in foods and toothpaste, so the sweeteners do not need to be added in the formula; xylitol is a natural sweetener extracted from plant raw materials such as white birch, oak, corncob, bagasse and the like, is widely contained in various fruits, vegetables and grains, is a natural and healthy sweetener, and can provide the function of preventing decayed teeth;
further, the water-soluble additive is one or a mixture of more of sodium phytate, citric acid and urea.
Adopt above-mentioned further beneficial effect to lie in: the sodium phytate adopted in the invention is from plant seeds and is a stain remover with natural effect and good performance; citric acid exists in fruits of plants such as lemon, orange, pineapple and the like, and can be used as a stain remover and a desensitizer in the toothpaste; the urea has an effective moisturizing effect, is present in the horny layer of the skin, belongs to the main component of the natural moisturizing factor NMF of the skin, and can also be used as a desensitizer in the formula of the toothpaste;
further, the foaming agent includes a liquid foaming agent and/or a powdery foaming agent;
the powdery foaming agent is sodium lauryl sulfate;
the liquid foaming agent is sodium lauroyl sarcosinate and/or sodium coconut monoglyceride sulfonate;
the friction agent is one or a mixture of more of crystal calcium carbonate, silicon dioxide and aluminum hydroxide;
the essence is one or more of natural aromatic oil such as lemon oil, oleum Menthae Dementholatum, oleum Rosae Rugosae, etc.
Adopt above-mentioned further beneficial effect to lie in: the lemon oil adopted by the invention is essential oil obtained by squeezing fresh peel of lemon, has fragrant and pleasant smell, has the functions of relieving asthma, eliminating phlegm, relieving cough, easing pain, resisting bacteria and diminishing inflammation and the like, is used as a food additive, and can also be used for flavoring food; the mint oil is essential oil extracted from mint, has special cool aroma, is used for enabling the toothpaste to have cool mouthfeel, contains menthol which can refresh breath and has multiple drug properties, has good curative effects on symptoms such as sore throat, gum swelling and pain and the like, and also has the effects of antisepsis, sterilization, phlegm reduction, stomach strengthening, digestion assistance and the like; roses are one of natural perfumes which are earlier applied by human beings, and rose oil can be used for preparing various essences, contains abundant natural vitamins C, GLA, protein, mineral substances and the like, and has certain antibacterial and bacteriostatic functions;
further, the preservative is vitamin E and/or tea tree essential oil.
Adopt above-mentioned further beneficial effect to lie in: the tea tree essential oil has extremely strong sterilization and anti-inflammation effects, is a natural preservative, and has a good treatment effect on sore throat, gingivitis and toothache. Meanwhile, the tea tree essential oil adopted by the invention has good cooperativity, namely when a plurality of essential oils are blended together for use, the tea tree essential oil can improve the smell, improve the effect and enhance the fragrance-spreading durability.
Compared with the prior art, the invention has the beneficial effects that: the pepper is dry mature pericarp of zanthoxylum or green pepper of zanthoxylum of Rutaceae, has strong pungent flavor and simple spicy flavor, can be used as a seasoning, has high medicinal value, can warm middle energizer and relieve pain, kill parasites and relieve itching, is used for treating abdominal psychroalgia, vomiting and diarrhea, abdominal pain caused by parasitic infestation, and can inhibit activities of i NOS and mRNA. The pepper spicy substance is a chain unsaturated fatty acid amide represented by sanshool, is a unique spicy component of pepper, is one of important indexes for identifying the quality of pepper, and has the effects of anesthesia, excitation, bacteriostasis, wind dispelling, dampness removing, insect killing, pain relieving and the like. The tsaoko amomum fruits are dry mature fruits of tsaoko amomum fruits of Zingiberaceae, and the tsaoko amomum fruits contain special and strong spicy fragrance, can be used as flavoring spices and medicines, and belong to one of bulk varieties of medicinal and edible traditional Chinese medicinal materials. Modern pharmacological studies prove that the amomum tsao-ko mainly contains volatile oil, the main components of the oil are alpha-pinene, beta-pinene, 1, 8-cineole, starch, grease, various trace elements and the like, and the amomum tsao-ko has the effects of relieving cough, eliminating phlegm, relieving asthma, easing pain, relieving fever, resisting inflammation, resisting bacteria, resisting oxidation and the like.
The invention takes the pepper essential oil and the tsaoko essential oil as effective medicinal components, and other various auxiliary materials are added for mutual action to prepare the medicinal toothpaste with special effects of diminishing inflammation, resisting bacteria, preventing sensitivity, easing pain and the like; the effective essential oil components are prepared into microcapsules and then added into the toothpaste, so that the drug effect and the fragrance are kept without loss.
The invention also provides a preparation method of the pricklyash peel and tsaoko amomum fruit toothpaste for relieving pain and diminishing inflammation, which comprises the following steps:
(1) weighing the raw materials according to the mass fraction of any one of claims 1 to 5;
(2) adding the adhesive into the humectant, and stirring at the rotating speed of 500r/min for 30-60 min at 300-;
(3) adding a water-soluble additive into deionized water, and uniformly stirring until the water-soluble additive is completely dissolved to obtain a solution 2;
(4) adding the solution 2 and the liquid foaming agent into the solution 1 at a stirring speed of 300-;
(5) adding a friction agent, a powdery foaming agent, essence, a preservative and the like into the solution 3, and uniformly stirring to obtain a paste body;
(6) grinding the paste obtained in the step (5) in a colloid mill for 40-60 min to obtain a smooth and fine toothpaste paste;
(7) adding the zanthoxylum essential oil microcapsules and the tsaoko amomum essential oil microcapsules into the toothpaste body, stirring at the rotating speed of 100-200r/min for 30-60 min, and then carrying out vacuum degassing to obtain the zanthoxylum bungeanum pain-relieving and inflammation-diminishing toothpaste.
Further, the preparation method of the pepper essential oil microcapsule and the tsaoko amomum fruit essential oil microcapsule in the step (1) comprises the following steps: putting the saturated microcapsule wall material solution into a water bath kettle, uniformly stirring at the rotating speed of 100-: 3-1: 5, respectively taking the zanthoxylum essential oil and the tsaoko amomum fruit essential oil, adding the zanthoxylum essential oil and the tsaoko amomum fruit essential oil into the microcapsule wall material solution while stirring, filtering the solution after uniformly stirring at the rotating speed of 100-70 r/min, and freeze-drying the obtained filter residue for 24 hours at the temperature of-70 ℃ to obtain zanthoxylum essential oil microcapsules and tsaoko amomum fruit essential oil microcapsules;
the wall material is chitosan and/or polyvinyl alcohol.
Adopt above-mentioned further beneficial effect to lie in: the freeze-drying method keeps the components and beneficial effects of the essential oil to the maximum extent, and the microcapsule has a good solid framework, so that the wall material has higher density, the essential oil can be better preserved, and the preservation time is longer.
Furthermore, the pericarpium Zanthoxyli essential oil and fructus Tsaoko essential oil are both supercritical CO2Fluid extraction to obtain said supercritical CO2The operation method of the fluid extraction comprises the following steps: removing impurities from fructus Zanthoxyli and fructus Tsaoko respectively, oven drying at 40-50 deg.C to constant weight, pulverizing, sieving, and adding supercritical CO2Extracting with fluid extraction equipment at 35-45 deg.C under 60-70Mpa for 4-6 hr to obtain pure oleum Zanthoxyli Bungeani and fructus Tsaoko essential oils.
Adopt above-mentioned further beneficial effect to lie in: supercritical CO2The fluid extraction technology has the characteristics of low temperature, no toxicity, high separation efficiency and the like. Oxidation and dissipation of the heat-sensitive substance can be effectively prevented. Therefore, all the components of the medicinal plants are kept in the extract, and high-boiling point, low-volatility and easily pyrolyzed substances can be extracted at the temperature below the boiling point of the substances; is particularly suitable for separating and extracting solid substances; the operation is performed under the condition of being close to normal temperature, the energy consumption is low, and the method is suitable forSeparating heat sensitive substances and easily oxidized substances; the method is the cleanest extraction method, and because no organic solvent is used in the whole process, the extract has no residual solvent, and simultaneously the method also prevents the poison to human bodies and the pollution to the environment in the extraction process, and is 100 percent of pure natural.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
(1) Removing impurities from fructus Zanthoxyli and fructus Tsaoko, respectively, oven drying at 40 deg.C to constant weight, pulverizing into powder with high speed pulverizer, and sieving. Respectively weighing a certain amount of pricklyash peel and tsaoko powder, and adding into supercritical CO2Extracting with fluid extraction equipment at 45 deg.C under 60Mpa for 5 hr to obtain pure fructus Zanthoxyli essential oil and fructus Tsaoko essential oil.
(2) Putting the saturated microcapsule wall material solution into a water bath kettle, uniformly stirring at the rotating speed of 100r/min, and then, mixing the solution according to the core-wall ratio of 1: 3, respectively taking the zanthoxylum essential oil and the tsaoko amomum fruit essential oil, adding the zanthoxylum essential oil and the tsaoko amomum fruit essential oil into the microcapsule wall material solution while stirring, filtering the solution after uniformly stirring at the rotating speed of 100r/min, and freeze-drying the obtained filter residue for 24 hours at the temperature of-70 ℃ to obtain zanthoxylum essential oil microcapsules and tsaoko amomum fruit essential oil microcapsules; the wall material is chitosan;
(3) accurately weighing 2% of hydroxyethyl cellulose, 12% of glycerol, 10% of sorbitol, 1% of sodium phytate, 0.5% of urea, 3% of sodium lauroyl sarcosinate, 50% of crystalline calcium carbonate, 1.5% of peppermint oil, 0.8% of tea tree essential oil, 0.5% of pepper essential oil microcapsule, 0.5% of tsaoko essential oil microcapsule and 18.2% of water;
(4) adding hydroxyethyl cellulose into the mixed solution of glycerol and sorbitol, and stirring at the rotating speed of 300r/min for 45min to uniformly disperse the hydroxyethyl cellulose in the moisture retention agent to obtain a solution 1;
(5) adding sodium phytate and urea into deionized water, and stirring uniformly until the sodium phytate and the urea are completely dissolved to obtain a solution 2;
(6) then adding the solution 2 and sodium lauroyl sarcosinate into the solution 1 at a stirring speed of 300r/min, uniformly stirring until the solution is transparent and has no particles, standing for 1.5h, fully expanding and peptizing the hydroxyethyl cellulose, and stirring for 40min at a speed of 300r/min to obtain a uniform and transparent solution, so as to obtain a solution 3;
(7) adding crystal calcium carbonate, peppermint oil and tea tree essential oil into the solution 3, and uniformly stirring to obtain a paste;
(8) grinding the mixed paste body in a colloid mill for 60min to further uniformly disperse the aggregated mass of the colloid and other raw materials to obtain a smooth and fine paste body of the toothpaste;
(9) adding the Zanthoxylum bungeanum essential oil microcapsules and the fructus tsaoko essential oil microcapsules into the toothpaste body, stirring at the rotating speed of 200r/min for 30min, performing vacuum degassing, and removing air in the toothpaste body to obtain a better sample formability, thereby obtaining the fructus Zanthoxyli fructus tsaoko analgesic and anti-inflammatory toothpaste.
Example 2
(1) Removing impurities from fructus Zanthoxyli and fructus Tsaoko, respectively, oven drying at 50 deg.C to constant weight, pulverizing into powder with high speed pulverizer, and sieving. Respectively weighing a certain amount of pricklyash peel and tsaoko powder, and adding into supercritical CO2Extracting with fluid extraction equipment at 35 deg.C under 70Mpa for 6 hr to obtain pure fructus Zanthoxyli essential oil and fructus Tsaoko essential oil.
(2) Putting the saturated microcapsule wall material solution into a water bath kettle, uniformly stirring at the rotating speed of 200r/min, and then, mixing the solution according to the core-wall ratio of 1: 5, respectively taking the zanthoxylum essential oil and the tsaoko amomum fruit essential oil, adding the zanthoxylum essential oil and the tsaoko amomum fruit essential oil into the microcapsule wall material solution while stirring, filtering the solution after uniformly stirring at the rotating speed of 200r/min, and freeze-drying the obtained filter residue for 24 hours at the temperature of-70 ℃ to obtain zanthoxylum essential oil microcapsules and tsaoko amomum fruit essential oil microcapsules; the wall material is polyvinyl alcohol;
(3) accurately weighing 1% of sodium alginate, 65% of sorbitol, 0.5% of sodium phytate, 1% of citric acid, 20% of silicon dioxide, 2% of sodium lauryl sulfate, 1% of rose oil, 1% of vitamin E, 0.5% of tea tree essential oil, 0.6% of pepper essential oil microcapsule, 0.4% of tsaoko amomum fruit essential oil microcapsule and 7% of water;
(4) adding sodium alginate into sorbitol, stirring at 500r/min for 30min to disperse sodium alginate in sorbitol to obtain solution 1;
(5) adding sodium phytate and citric acid into deionized water, and stirring uniformly until the sodium phytate and the citric acid are completely dissolved to obtain a solution 2;
(6) then adding the solution 2 into the solution 1 at a stirring speed of 500r/min, uniformly stirring until the solution is transparent and has no particles, standing for 1h, fully expanding and peptizing the sodium alginate, and then stirring for 30min at a speed of 500r/min to obtain a uniform and transparent solution, thus obtaining a solution 3;
(7) adding silicon dioxide, sodium lauryl sulfate, rose oil, vitamin E and tea tree essential oil into the solution 3, and uniformly stirring to obtain a paste;
(8) grinding the mixed paste body in a colloid mill for 50min to further uniformly disperse the aggregation of the raw materials to obtain a smooth and fine paste body of the toothpaste;
(9) adding the Zanthoxylum bungeanum essential oil microcapsules and the tsaoko amomum tsaoko essential oil microcapsules into the toothpaste body, stirring at the rotating speed of 100r/min for 60min, then carrying out vacuum degassing, and removing air in the toothpaste body to ensure that the toothpaste has better formability, thus obtaining the Zanthoxylum bungeanum analgesic and anti-inflammatory toothpaste.
Example 3
(1) Removing impurities from fructus Zanthoxyli and fructus Tsaoko respectively, oven drying at 45 deg.C to constant weight, pulverizing into powder with high speed pulverizer, and sieving. Respectively weighing a certain amount of pricklyash peel and tsaoko powder, and adding into supercritical CO2Extracting with fluid extraction equipment at 40 deg.C under 65Mpa for 4 hr to obtain pure fructus Zanthoxyli essential oil and fructus Tsaoko essential oil.
(2) Putting the saturated microcapsule wall material solution into a water bath kettle, uniformly stirring at the rotating speed of 150r/min, and then, mixing the solution according to the core-wall ratio of 1: 4, respectively taking the zanthoxylum essential oil and the tsaoko amomum fruit essential oil, adding the zanthoxylum essential oil and the tsaoko amomum fruit essential oil into the microcapsule wall material solution while stirring, filtering the solution after uniformly stirring at the rotating speed of 150r/min, and freeze-drying the obtained filter residue for 24 hours at the temperature of-70 ℃ to obtain zanthoxylum essential oil microcapsules and tsaoko amomum fruit essential oil microcapsules; the wall material is chitosan and polyvinyl alcohol;
(3) accurately weighing 3% of Lota type carrageenin, 10% of glycerol, 15% of xylitol, 1% of citric acid, 0.8% of urea, 2.5% of sodium coconut monoglyceride sulfonate, 45% of aluminum hydroxide, 2% of lemon oil, 1% of vitamin E, 0.8% of pepper essential oil microcapsule, 0.2% of tsaoko amomum fruit essential oil microcapsule and 18.7% of water;
(4) adding the Lota-type carrageenin into the mixed solution of glycerol and xylitol, stirring at 450r/min for 60min to uniformly disperse the Lota-type carrageenin in the humectant to obtain solution 1;
(5) adding citric acid and urea into deionized water, and uniformly stirring until the citric acid and the urea are completely dissolved to obtain a solution 2;
(6) then adding the solution 2 and sodium coconut monoglyceride sulfonate into the solution 1 at a stirring speed of 450r/min, uniformly stirring until the solution is transparent and free of particles, standing for 2h to ensure that the Lota type carrageenin is fully expanded and peptized, and then stirring for 60min at a speed of 450r/min to obtain a uniform and transparent solution, thus obtaining a solution 3;
(7) adding aluminum hydroxide, lemon oil and vitamin E into the solution 3, and uniformly stirring to obtain a paste;
(8) grinding the mixed paste in a colloid mill for 40min to further uniformly disperse the colloid or other aggregated masses of the raw materials to obtain a smooth and fine paste of the toothpaste;
(9) adding the Zanthoxylum bungeanum essential oil microcapsules and the tsaoko amomum tsaoko essential oil microcapsules into the toothpaste body, stirring at the rotating speed of 150r/min for 45min, then carrying out vacuum degassing, and removing air in the toothpaste body to ensure that the toothpaste has better formability, thus obtaining the Zanthoxylum bungeanum analgesic and anti-inflammatory toothpaste.
Evaluation of Effect
The tested volunteers are selected to be 120 persons in total, 60 persons in male and female, the ages of the male and female are 10-60 years old, the numbers of the male and female are 1-120, and the following conditions are all carried out to different degrees: inflammation of gums, swelling and pain, bleeding, tooth sensitivity, halitosis, etc. The toothpaste provided by the present invention was used 2-3 times per day, with nos. 1-40 using the product of example 1, nos. 41-80 using the product of example 2, and nos. 81-120 using the product of example 3.
After the test is carried out for one month, the comprehensive condition of the testee is evaluated, and the testee is found to have no adverse reaction, and the conditions of gingival inflammation, swelling and pain, bleeding, tooth sensitivity and the like are greatly improved: halitosis is also significantly reduced.
The fructus Zanthoxyli has effects of anesthesia, excitation, bacteriostasis, dispelling pathogenic wind, removing dampness, killing parasite and relieving pain. The fructus Tsaoko has antitussive, expectorant, antiasthmatic, analgesic, antipyretic, antiinflammatory, antibacterial, and antioxidant effects. The extracted essential oil has high potential economic value and application prospect for dual purposes of fragrance and medicine, has the functions of diminishing inflammation, resisting bacteria and easing pain when being applied to toothpaste, and can effectively relieve various oral problems such as gingival inflammation, swelling and pain and the like.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (9)
1. The pricklyash peel and tsaoko amomum fruit toothpaste for relieving pain and diminishing inflammation is characterized by comprising the following raw materials in percentage by mass: 0.5-0.8% of pepper essential oil microcapsule, 0.2-0.5% of tsaoko essential oil microcapsule, 1-3% of adhesive, 22-65% of humectant, 1.5-1.8% of water-soluble additive, 20-50% of abrasive, 2-3% of foaming agent, 1-2% of essence, 1-1.5% of preservative and the balance of deionized water.
2. The prickly ash fruit toothpaste for easing pain and diminishing inflammation according to claim 1, wherein the adhesive is one or a mixture of sodium alginate, hydroxyethyl cellulose and Lota type carrageenin;
the humectant is one or a mixture of more of glycerol, sorbitol and xylitol.
3. The prickly ash fruit toothpaste for easing pain and diminishing inflammation according to claim 1, wherein the water-soluble additive is one or a mixture of sodium phytate, citric acid and urea.
4. The prickly ash fruit toothpaste of claim 1, wherein the foaming agent comprises a liquid foaming agent and/or a powder foaming agent;
the powdery foaming agent is sodium lauryl sulfate;
the liquid foaming agent is sodium lauroyl sarcosinate and/or sodium coconut monoglyceride sulfonate.
5. The prickly ash fruit toothpaste for easing pain and diminishing inflammation according to claim 1,
the friction agent is one or a mixture of more of crystal calcium carbonate, silicon dioxide and aluminum hydroxide;
the essence is one of natural aromatic oils such as lemon oil, peppermint oil and rose oil;
the antiseptic is vitamin E and/or tea tree essential oil.
6. The preparation method of the pricklyash peel and tsaoko amomum fruit toothpaste for relieving pain and diminishing inflammation is characterized by comprising the following steps of:
(1) weighing the raw materials according to the mass fraction of any one of claims 1 to 5;
(2) adding the adhesive into the humectant, and stirring at the rotating speed of 500r/min for 30-60 min at 300-;
(3) adding a water-soluble additive into deionized water, and uniformly stirring until the water-soluble additive is completely dissolved to obtain a solution 2;
(4) adding the solution 2 and the liquid foaming agent into the solution 1 at a stirring speed of 300-;
(5) adding a friction agent, a powdery foaming agent, essence, a preservative and the like into the solution 3, and uniformly stirring to obtain a paste body;
(6) grinding the paste obtained in the step (5) in a colloid mill for 40-60 min to obtain a smooth and fine toothpaste paste;
(7) adding the zanthoxylum essential oil microcapsules and the tsaoko amomum essential oil microcapsules into the toothpaste body, stirring at the rotating speed of 100-200r/min for 30-60 min, and then carrying out vacuum degassing to obtain the zanthoxylum bungeanum pain-relieving and inflammation-diminishing toothpaste.
7. The preparation method of the pricklyash peel and tsaoko amomum fruit toothpaste capable of relieving pain and diminishing inflammation according to claim 6, wherein the preparation method of the pricklyash peel essential oil microcapsules and the tsaoko amomum fruit essential oil microcapsules in the step (1) comprises the following steps: putting the saturated microcapsule wall material solution into a water bath kettle, uniformly stirring at the rotating speed of 100-: 3-1: 5, respectively taking the zanthoxylum essential oil and the tsaoko amomum fruit essential oil, adding the zanthoxylum essential oil and the tsaoko amomum fruit essential oil into the microcapsule wall material solution while stirring, filtering the solution after uniformly stirring at the rotating speed of 100-70 r/min, and freeze-drying the obtained filter residue for 24 hours at the temperature of-70 ℃ to obtain zanthoxylum essential oil microcapsules and tsaoko amomum fruit essential oil microcapsules;
the wall material is chitosan and/or polyvinyl alcohol.
8. The preparation method of the pricklyash peel and tsaoko amomum fruit toothpaste capable of relieving pain and diminishing inflammation according to claim 7, wherein the pricklyash peel essential oil and the tsaoko amomum fruit essential oil both adopt supercritical CO2And extracting by using fluid extraction equipment.
9. The method for preparing the Zanthoxylum bungeanum toothpaste for relieving pain and diminishing inflammation according to claim 8, wherein the supercritical CO is2The operation method of the fluid extraction comprises the following steps: removing impurities from fructus Zanthoxyli and fructus Tsaoko respectively, oven drying at 40-50 deg.C to constant weight, pulverizing, sieving, and adding supercritical CO2Extracting with fluid extraction equipment at 35-45 deg.C under 60-70Mpa for 4-6 hr to obtain pure oleum Zanthoxyli Bungeani and fructus Tsaoko essential oils.
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| CN107320402A (en) * | 2017-08-24 | 2017-11-07 | 何家平 | A kind of antiodontalgic toothpaste technique |
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