KR20170030209A - Toothpaste composition having oral cavity antibacterial effect - Google Patents

Abstract

The present invention relates to a toothpaste composition which is safe, has an excellent antibacterial effect, and is highly preferred, by including natural extracts. The toothpaste composition comprises: 6-20 wt% of an herb extract selected from a spearmint extract, a pine extract, a lemongrass extract, a Chinese pepper extract, and a mixture consisting of two or more components from among the extracts; 15-20 wt% a surfactant; 15-20 wt% of an abrasive material; 0.5-1.5 wt% of a viscosity regulator; 15-20 wt% of a cleansing agent; 1-5 wt% of at least one additive selected from a group consisting of a preservative, an air freshener, a coloring agent, a sweetener, an antioxidant agent, and an antibacterial agent; and a wetting agent as a residual quantity.

Description

Toothpaste composition having oral cavity antibacterial effect [

The present invention relates to a dentifrice composition having an oral antimicrobial effect, and more particularly to a dentifrice composition containing a natural product extract, which is safe, exhibits excellent antimicrobial effect and is highly desirable.

Oral Cavity is an important organ for respiration and food intake, but it is also an organization that is constantly exposed to external environments through air and food. If oral cleaning is not maintained through tooth brushing, a dental plaque is created on the periphery of the teeth and gums, and the resulting dental plaque gradually becomes calcified to form a dental calculus on the tooth surface. These dental plaques and dental calculus can cause gum disease such as gingivitis and periodontitis by proliferating oral bacteria.

As a result, most people brush their teeth regularly using toothpaste after meals. Toothpaste is a quasi-drug used for brushing the surface of teeth. It is mainly used for the purpose of whitening effect, sterilization effect, and interdental cleaning effect. For this purpose, toothpaste generally contains ingredients such as abrasive, wetting agent, foaming agent and sweetener .

In recent years, studies have been actively conducted to manufacture dentifrices having excellent effects such as treatment of gum disease and removal of bad breath using natural medicinal herbs.

Korean Patent Laid-Open No. 2005-0078923 discloses a dental caries prevention and dentifrice composition for preventing periodontal disease, which is prepared by adding an extract obtained from daphnia magna, green tea, papoji or dansam to a raw material of abrasive, detergent and fluoride preparation.

In addition, Korean Patent No. 852,881 discloses a pharmaceutical composition for preventing and treating periodontal disease, which contains a mixed extract of Safflower and Mt.

It is an object of the present invention to provide a dentifrice composition containing a natural extract, which is safe, has excellent antimicrobial effect and is highly desirable.

In order to achieve the object of the present invention, the dentifrice composition having an oral antimicrobial effect may comprise a herb extract 6 to 6 selected from the group consisting of spearmint extract, pine extract, lemongrass extract, 20% by weight; 15 to 20% by weight of a surfactant; 15 to 20% by weight of abrasive; 0.5 to 1.5% by weight of a viscosity modifier; 15 to 20% by weight of a detergent; 1 to 5% by weight of at least one additive selected from the group consisting of preservatives, perfumes, coloring agents, sweeteners, antioxidants and antibacterial agents; And a wetting agent as a remaining amount.

The dentifrice composition may further include a herbal essential oil in an amount within a range of 0.5 to 2 parts by weight based on 100 parts by weight of the dentifrice composition.

According to the present invention, it is possible to provide a safe, excellent antimicrobial effect and a high degree of preference for a high-purity animal including extracts of natural products, especially herbal extracts selected from the group consisting of spearmint extract, pine extract, lemon grass extract, A dentifrice composition is provided.

Hereinafter, the present invention will be described in detail with reference to specific examples.

The dentifrice composition having an oral antimicrobial effect according to the present invention comprises 6 to 20% by weight of a herbal extract selected from the group consisting of Spearmint extract, Pine extract, Lemon grass extract, Acanthopanax extract, and a mixture of two or more thereof; 15 to 20% by weight of a surfactant; 15 to 20% by weight of abrasive; 0.5 to 1.5% by weight of a viscosity modifier; 15 to 20% by weight of a detergent; 1 to 5% by weight of at least one additive selected from the group consisting of preservatives, perfumes, coloring agents, sweeteners, antioxidants and antibacterial agents; And a wetting agent as a remaining amount.

The Spearmint extract may be a spearmint ( Mentha spicata ) is extracted with steam distillation method, and the flavor and properties are pale yellow or olive essential oil of warm and poached mint flavor. The main components include L-carvone, dihydrocarvone, limonene, menton, menthol, phellandrene, pulegone, cineol, linarol, pinene and the like. The efficacy and efficacy are excellent in digestion promotion, phagocytosis, antiseptic, antiviral, antibacterial, anti-inflammatory, geomorphic, antipyretic, analgesic, concentration, bleeding and hormone control; It is widely used for the healing and improvement of digestive and respiratory diseases; It is also used for massage oils and creams that relieve pain of muscles because of its excellent antipyretic and pain relieving effect; It has antibacterial, antiviral and antimicrobial properties. It has the function of disinfecting and healing the skin. It helps to improve and heal all kinds of inflammatory skin such as acne and oily skin. It also has a preservative effect; And it is effective to relieve headache. It is also effective in disinfecting and healing wounds such as inflammation and scab, and it has a cool and refreshing fragrance that stabilizes the mind and body. It provides local anesthetics, fungicide, anticonvulsant, astringent, perspiration, It is used as a remover, a digestive agent, a diuretic, an expectorant, a heating agent, a hepatic agent, a sedative, a stimulant, an appetite enhancer and a tonic agent, and has a similar property to peppermint as a whole. However, Fragrance and fragrance materials, toothpaste and quasi-drugs, gum, candy, and beverages.

The pine extract is a colorless or pale yellow essential oil of a fresh and refreshing woody note, which is obtained by steam distillation of fresh leaves of Pine sylvestris . The main ingredients are pinene, but are not limited to, carene, dipentene, limonene, camphene, terpinene, citral, bornyl acetate, ocimene, myrcene, sabinene, ) And the like. Pine trees are used when Hippocrates is caused by bronchial and respiratory anomalies, and it is also known to be used for the treatment of pneumonia. Unique fragrances are components that show excellent effects in the treatment of various diseases of the lungs, and it is known that when sleeping in the pine forests, the life span of human beings is prolonged, many are being planted in nursing homes and the like. Its efficacy and effects are unique and refreshing to prevent drowsiness with its unique pine aroma, restore fatigue and give new vitality to the body; Strong antibacterial, germane, mucus hypersensitivity, and nasal mucus discharge effect is excellent and is effective for healing and improvement of respiratory diseases such as cold and bronchitis; Very strong analgesic, anti-fever effect and blood circulation, which helps to improve the osteoarthritis, rheumatism and muscle aches for massage oils are used as a lot; Improve circulation flow to improve obesity and rejuvenate skin; It also has anti-bacterial and anti-inflammatory effect, capillary shrinkage and sebaceous gland control effect. It is effective to improve the trouble of oily skin such as acne, and is effective against antimicrobial agent, anti-neuron control, antirheumatic agent, antipyretic agent, deodorant, diuretic, It is used as a synergistic agent, insecticide, remedy, corticosteroid and blood circulation, stimulant of nerve, insect repellent and so on, and also in cosmetics such as soap, toothpaste, deodorant, disinfectant, detergent, men lotion and skin, massage cream for improving blood circulation It is widely used.

The above-mentioned lemon grass extract is a lemon grass ( Cymbopogon citratus , and the extraction can preferably be carried out by steam distillation. The fragrance and properties are crisp, oily citrus and earthy yellow or reddish brown essential oils, and the main ingredients are citral, myrcene, dipentin, linacol, eraniol, (methylheptenone), nerol, farnesol, methyl eugenol, citronelloll, geraniol, etc. The efficacy and efficacy of the composition is enhanced by fresh air, Restore and recharge energy; It has antibacterial action and is good for the improvement of respiratory diseases such as sore throat and bronchitis; Stimulates parasympathetic nerves to promote digestion and is effective in relieving stomach pain; It has the effect of stimulating the circulation by removing lactic acid, and is excellent in the improvement of muscular pain; It has a pore-shrinking effect, improves the balance of sebum secretion, improves oily skin such as acne and is also effective in the treatment of athlete's foot; In India and elsewhere, it has been used for a long time as a traditional folk remedy for diseases such as digestive system diseases, analgesics and rheumatism, and essential oils contain strong antibacterial, antiseptic and insecticidal compounds. It is widely used as an antimicrobial agent, an antioxidant, an astringent, a deodorant, a fungicide disinfectant, an insecticide, a pesticide, a neurotilizer and a tonic agent and is also widely used as a fragrance for soap, cosmetics, perfume, It is widely used as an additive.

The acidic extracts of Zanthoxylum It is known that the extracts of schinifolium are hydrolyzed and have antimicrobial, anti-inflammatory, analgesic and insecticidal effects. The main ingredients are Acetoxyauraptene, Epoxycollinin, Schininallyol, Schinilenol, Schinindiol, Acetoxycollinin, Schinifoline, N-Methylschinifoline, 3,7,8-trimethoxy-2H-1 3,7,8-trimethoxy-2H-1-benzopyran-2-one, alpha-Sanshool, Bergapten, Estragole, etc. . The hot water extraction is preferably carried out by adding 5% by weight of water-soluble phenolic resin to 95% by weight of water and heating at 110 DEG C for about 6 hours. After extraction, 2% by weight of 1,2- . Japanese pepper tree is a deciduous shrub belonging to Rutaceae (Rutaceae), which grows mainly in East Asia, including China, including Korea, Japan, Taiwan, Korea, and has six paper grows. About 64 kinds of plants of Sanoh are used as spices and medicines. As the most representative plants, Wanthoxylum bungeanum Maxim and Zanthoxylum schinifolium Sieb et Zucc , Zanthoxylum piperidine DC. ). Sancho woods grow in mountainous areas, about 3m high, with twigs in thorns and reddish brown. Leaves are alternate phyllotaxis and consist of 13 to 21 small leaves, and small leaves are long oval with 1 to 5 cm long. The fruit is capillary, round, 4㎜ long, greenish brown, and ripened into three pieces, resulting in black seeds. Sancho is useful in gastrointestinal diseases, gastrointestinal diseases, inflammation, diuresis, insect repellent, and has been used for various diseases such as anorexia, toothache, hypotension, cold, asthma, The maturing acidulant fruit contains a large amount of essential oil components containing various fatty acids, and is used in the treatment of gastric acid and bronchial asthma in the private sector in the case of peanut oil extracted by removing the skin. In the previous studies, it was reported that Sancho essential oil decreased the inflammatory mediators and showed potential as a functional plant material to prevent the oxidation activity. It has been reported that antioxidative, whitening, and anti-inflammatory activities of the ethanol extract of Sanchos against Vibrio parahaemolyticus are known to be effective in the treatment of acidosis. In addition, Sancho is used as a medicament for the medicines of Tampa, which is reported to be effective for antibacterial, dermatological, and anti-inflammatory effects in the study of antimicrobial activity by this medicament. The methanol extract of anthocyanin has an excellent antioxidant activity due to its high content of quercetin. The chloroform fraction has been reported to have a high antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Chironomycetes. Lee, Sang - Kon through the study of the Japanese pepper extract was effectively inhibit intraoral dental caries causing bacteria of Streptococcus mutans (S. mutans) activity, was increased antibacterial efficacy, the antioxidant efficacy is confirmed that the increases in proportion to the concentration of the extract . In addition, S. aureus and Streptococcus mutans have strong antimicrobial activity compared to bacillus.

In the present invention, herbal extracts selected from the group consisting of Spearmint extract, Pine extract, Lemon grass extract, Acanthamo juice extract and mixtures of two or more thereof are contained in an amount within a range of 6 to 20% by weight based on the total weight of the dentifrice composition If the herbal extract is contained in an amount of less than 6% by weight, the oral antimicrobial effect and the degree of preference may be deteriorated. If the herbal extract is more than 20% by weight, There may be a problem.

The surfactant enhances mixing and formulation stability of the components constituting the dentifrice composition according to the present invention and enhances the cleaning effect. The surfactant is not particularly limited, but natural vegetable fatty acids may be used. In particular, in the present invention, it may be preferable to use a vegetable fatty acid having an HLB of 10 to 20 and a vegetable fatty acid having an HLB of 1 to 5 in combination. It is understood that the vegetable fatty acids of HLB 10 to 20 are commercially available and can be purchased under the trade name of Polysorbate 80. It is a non-ionic hydrophilic solubilizing agent such as skins, oil-in-water (O / W) type emulsifying aid, and active ingredient absorption promoter. Solubilizer obtained by extraction / purification of fatty acid of plant such as coconut, palm, castor, It is most widely used because of its excellent auxiliary function; Promoting absorption of functional active ingredients into skin cells through wetting (wetting) action at the surface of the skin, supporting functional improvement of the product; The degree of irritation and harmfulness of the skin is lower than that of olive liquid, which is known as a solubilizing agent derived from natural origin. Fatty acids extracted from vegetable natural oils such as coconut, palm, and castor, and they are widely used for the production of basic cosmetics, cleaning cosmetics, perfumes and the like. The vegetable fatty acids of HLB 1 to 5 may be commercially available and commercially available under the trade name of G-mixture (Sorbitan Tristearate). have. It has functions such as water-in-oil type (hydrophilic) emulsifier, water-in-oil type emulsifying aid and active ingredient absorption accelerator, and acts as a nonionic emulsifier at the interface to lower the interfacial tension. Excellent in alkalinity; It is a lipophilic emulsifier obtained by extracting / purifying the fatty acids of plants such as coconut, palm and castor. It is widely used for the production of various emulsifying cosmetics, medicines, foods and the like because it has excellent emulsifying power of water-in-water type and emulsifying auxiliary function of underwater type. Since it has little effect on the formulation of the product, it provides a very light and refreshing feel compared with conventional wax emulsifiers. Especially, it is very stable when applied to low viscosity, water-in-oil emulsions or water-in-oil emulsions. And it is rarely used as a sole emulsifier in the production of emulsified cosmetics. In most cases, it is used together with hydrophilic emulsifiers such as natural liquid, T-mixer, and pure liquid. It promotes the uptake of functional ingredients into skin cells through wetting (wetting) action on the surface of the skin, thus enhancing the functional effects of the product. The surfactant is contained in an amount within a range of 15 to 20 wt% based on the total weight of the dentifrice composition. When the surfactant is used in an amount of less than 15 wt%, it is difficult to prepare and maintain a proper formulation, And if it exceeds 20% by weight, the lack of other ingredients may make it difficult to obtain an appropriate dentifrice composition.

The abrasive is a component that cleans the teeth by imparting a lubricating effect (smoothing) and a whitening effect to the teeth, and is an indispensable component for removing foreign substances adhered to the surface of the teeth. The abrasive may be selected from the group consisting of silica, sodium hydrogencarbonate (sodium bicarbonate), calcium carbonate, and a mixture of two or more thereof, although there is no particular limitation. The abrasive is contained in an amount within a range of 15 to 20% by weight based on the total weight of the dentifrice composition. When the abrasive is used in an amount of less than 15% by weight, the polishing effect of the tooth and the whitening effect and the foreign matter And if it exceeds 20% by weight, the lack of other ingredients may make it difficult to obtain an appropriate dentifrice composition.

The viscosity modifier is a component that functions to adjust the viscosity of the composition to maintain the formulation as a toothpaste. The viscosity modifier is not particularly limited, but preferably an echogen can be used. Echo black viscosity control function, film forming function, skin softening function, and skin moisturizing functions, which are particularly suitable in the present invention. The echo black cabbage etc. yeopso bottle of Plants generated causative of janto Pseudomonas Kam paste-less (Xanthomonas Campestris) the use, purified high molecular polysaccharide gum (Gum) material which is obtained by pure culture fermentation of carbohydrates in isopropyl alcohol (Isopropyl alchol), dried , And viscosity regulators of polysaccharides derived from natural products produced by pulverization. It is a mixture of sodium, potassium and calcium salts of glucose, mannose and glucuronic acid, and is dispersed in cold water. It is a mixture of glucose, mannose and glucuronic acid, which is a raw material of natural ingredients with a transparency of 5 times higher and a resistance of 3 times or more, It dissolves in hot water and does not cause viscosity difference due to temperature at dissolution. It is one of the most widely used water-soluble viscosity controlling raw materials which is not soluble in solvents such as ethanol and oil components. It provides skin softening and skin moisturizing functions and effects through formation of a thin film on the skin surface. In addition, it has excellent acid resistance and has no viscosity drop due to pH change, and maintains a stable viscosity even in the range of pH 2 to 13. Used in basic cosmetics and cleaning cosmetics. In the food sector, it is also a safe substance used as a thickening agent, binder, foaming agent, and the like. The viscosity controlling agent is contained in an amount within a range of 0.5 to 1.5% by weight based on the total weight of the dentifrice composition, and when it is used in an amount of less than 0.5% by weight, there may be a problem that maintenance of the formulation as toothpaste becomes insufficient, %, It may be difficult to obtain an appropriate dentifrice composition due to the lack of other components.

The detergent is a component that functions to remove foreign substances on the tooth surface and oral cavity to enhance the cleaning effect. The detergent is not particularly limited, but may preferably be selected from the group consisting of coco betaine, clay, bentonite, and a mixture of two or more thereof. The detergent is contained in an amount within a range of 15 to 20% by weight based on the total weight of the dentifrice composition. If the detergent is used in an amount less than 15% by weight, If it exceeds 20% by weight, the lack of other components may make it difficult to obtain an appropriate dentifrice composition.

The additive is a component selected from the group consisting of a preservative, a fragrance, a coloring agent, a sweetener, an antioxidant and an antimicrobial agent. It enhances the storage stability of the toothpaste, increases the preference of the user (consumer) Which does not directly affect the efficacy of the toothpaste itself. However, it can be understood as a component that enhances the utility as a product. Such additives are well known to those skilled in the art so that they can be purchased and used commercially. It can be. For example, synthetic fragrances can be used as well as L-menthol and / or a plant essential oil (for example, essential oils of lemon) can be used as a fragrance. The additive may be added in an appropriate amount as necessary and may be added in an amount within a range of 15 to 20 wt% based on the total weight of the dentifrice composition, preferably in an amount within a range of 1 to 5 wt% have.

The wetting agent (moisturizing agent) is a component that provides a moisturizing effect and a lipolytic effect, and is the most widely used ingredient in all parts of the base and cleansing cosmetics. The wetting agent is not particularly limited, but preferably glycerin can be used. It is a kind of aliphatic trihydric alcohol and is a colorless, transparent, sweet and viscous liquid raw material, and is a fatty acid- It is distributed in plants and animals in the form of lipids and is also produced as a byproduct in the production of soap by saponification reaction with the oil. It is highly hygroscopic and is well dissolved and mixed in water and alcohol, but it has cost and non-mixing properties in oil components (especially hydrocarbons). Moisture absorbing and absorbing to suppress the evaporation of water through the action to support the moisturizing function and effects, but when used in excess of the skin to absorb the moisture is known to cause rather dry skin. In the past, glycerin produced through saponification reaction using oil (fat) or the like was used, but recently, it is produced / produced through alcohol fermentation process (biodiesel production process) using synthesis or yeast. It is widely used in basic cosmetics and cleansing cosmetics, fat-degrading cosmetics, foodstuffs, gamma-agents, and flavoring agents. In the pharmaceutical sector, it is also used as a binder and a moisturizer.

The dentifrice composition according to the present invention may further comprise a herbal essential oil in an amount within a range of 0.5 to 2 parts by weight based on 100 parts by weight of the dentifrice composition. The herbal essential oil is a component that refreshes the mouth by providing a unique direction of the toothpaste for enhancing the user's preference. The herb essential oil is not particularly limited but may preferably be selected from the group consisting of spearmint essential oil, pine essential oil, lemon essential oil, and a mixture of two or more thereof.

There is no limitation on the extraction method of the herbal essential oil, but preferably the steam extraction method can be used. The extraction of the herbal essential oil by the steam extraction method is briefly described below, but the present invention is not intended to be limited thereto.

1. Purchase and purchase the raw horticultural herb on the same day

2. Hub classification operation

3. Hub cutting work (about 10 cm)

4. After the herb washes, add herbal ingredients to the herb extractor tank

5. Operation of the herb extractor

6. Hub extraction operation for about 3 hours and 30 minutes after starting the extractor

The herbal essential oil extraction method will be described in detail as follows.

The herb raw cut is put into the extractor tank by 250 kg, the steam steam refined by the steam boiler operation is sucked into the extraction tank, and the preheating operation is performed for about 1 hour. At this time, decompression is applied so that the raw material of the hub is automatically classified into heat steam and pressure.

When the temperature of the extraction tank reaches 100 ° C, the steam discharge valve is opened to discharge the primary mixed steam to the outside for about 3 minutes to purify the steam in the extractor. The pressure of the steam is increased again to increase the pressure, When the pressure reaches 1.5 kg, open the steam extraction valve and the coolant valve to start the hub oil separation operation.

When the oil and the hydrosol are separated from each other in the fractionating tank, the hydrosol is extracted to about 200 kg over about 3 times, the hydrosol residue containing the final oil is withdrawn, To separate the hydrosol and oil. In order to obtain pure oil from the separated oil layer, firstly separated oil is kept in the freezer for one day and only oil that is not frozen is collected.

Hereinafter, preferred embodiments and comparative examples of the present invention will be described.

The following examples are intended to illustrate the invention and should not be construed as limiting the scope of the invention.

Example 1

The dentifrice composition according to the present invention was obtained by combining the ingredients as shown in Table 1 below.

Ingredients Content (% by weight) Herbal extract Spearmint extract 17 Surfactants Fatty acid (HLB: 15) 8 Fatty acid (HLB: 2.1) 10 abrasive Silica 10 Sodium hydrogencarbonate 2 Calcium carbonate 5 Viscosity modifier Eco-sword One detergent Coco Betaine 15 Clay 2 Bentonite 2 additive Xylitol (sweetener) 5 L-menthol (fragrance) One Other additives 2 Wetting agent glycerin 20

Step 1: The ingredients (wetting agent and viscosity adjusting agent) of Group 1 were weighed into a prepared container, and then slowly stirred until the viscosity controlling agent was completely dissolved / dispersed.

Step 2: The ingredients (herb extract) of Group 2 were weighed and added to the mixture obtained in the first step, and the mixture was homogeneously mixed while gradually heating to about 40 캜.

Step 3: The raw materials of Group 3 (surfactants) were weighed in a separate vessel, and mixed until homogeneously mixed until the fatty acids were completely dissolved / mixed while gradually heating to about 50 ° C.

Step 4: The mixture obtained in the third step was added to the mixture obtained in the second step and mixed homogeneously using a stirrer.

Step 5: To the mixture obtained in the fourth step, the raw materials of Group 4 (cleaning agent, abrasive and a part of the additives (sweeteners)) were weighed and added, and then mixed homogeneously.

Step 6: The mixture obtained in the fifth step was weighed and added to the raw material of group 5 (the remaining additives), and then mixed uniformly for 20 to 30 minutes.

Step 7: 0.25 parts by weight of spearmint essential oil, 0.25 parts by weight of pine essential oil and 0.5 part by weight of lemon grass essential oil were weighed and added as hub essential oils, respectively, based on 100 parts by weight of the mixture obtained in the sixth step at room temperature, Lt; / RTI >

Step 8: The finished dentifrice composition obtained in the seventh step was aged at room temperature for one week and then injected into the prepared container.

Example 2

The dentifrice composition according to the present invention was obtained in the same manner as in Example 1 except that the same amount of pine extract was used instead of the spearmint extract in Table 1 above.

Example 3

The dentifrice composition according to the present invention was obtained in the same manner as in Example 1, except that the same amount of lemon grass extract was used instead of the spearmint extract in Table 1 above.

Example 4

The dentifrice composition according to the present invention was obtained in the same manner as in Example 1, except that an equivalent amount of an acid-licorice extract was used instead of the spearmint extract in Table 1 above.

Example 5

The dentifrice composition according to the present invention was obtained in the same manner as in Example 1, except that 8.5% by weight of lemon grass extract and 8.5% by weight of acid pickle extract were used instead of 17% by weight of spearmint extract in Table 1 above.

Example 6

In the same manner as in Example 1, except that spearmint extract, lemongrass extract, pine extract, and sancho extracts were replaced by equivalent amounts (i.e., 4.25 wt% each) instead of 17 wt% of spearmint extract in Table 1 To obtain a dentifrice composition according to the present invention.

Experimental Example 1: Antimicrobial activity

The antimicrobial activity against Streptococcus mutans , which is one of the causative bacteria of cavities, was tested three times using the concentrations of the above Examples 1 to 6, and the results were expressed as mean and standard deviation in Tables 2 to 5 (Unit: mm).

Name of sample Concentration (10 μl / disc) Average Standard Deviation One 2 3 Example 1 - - - - - Example 2 - - - - - Example 3 - - - - - Example 4 - - - - - Example 5 7.60 7.70 7.70 7.67 0.06

Name of sample Concentration (20 l / disc) Average Standard Deviation One 2 3 Example 1 - - - - - Example 2 - - - - - Example 3 - - - - - Example 4 - - - - - Example 5 11.50 10.80 10.00 10.77 0.75 Example 6 10.00 9.70 10.70 10.13 0.51

Name of sample Concentration (50 / / disc) Average Standard Deviation One 2 3 Example 1 - - - - - Example 2 - - - - - Example 3 9.50 9.10 9.60 9.40 0.26 Example 4 14.50 14.80 14.10 14.47 0.29 Example 5 19.10 18.30 19.00 18.80 0.44 Example 6 18.80 18.20 18.70 18.57 0.32

Name of sample Concentration (100 μl / disc) Average Standard Deviation One 2 3 Example 1 - - - - - Example 2 - - - - - Example 3 10.40 10.00 9.60 10.00 0.40 Example 4 NT NT NT NT NT Example 5 NT NT NT NT NT Example 6 23.90 25.30 25.60 24.93 0.91

In Table 2 to 5, "-" means that no clean area was present enough to measure the antimicrobial activity. Also, in the above Tables and Table 5, "NT" means that the experiment was not performed because the disc had a characteristic of absorbing only 50 μl at maximum.

As a control, gentamicin was used to measure the antimicrobial activity under the same experimental conditions, and the results are shown in Table 6 below.

Name of sample Concentration (0.1 mg / disc) Average Standard Deviation One 2 3 Gentamicin 35.10 34.70 34.30 34.70 0.40

As a result of synthesizing the above embodiments, the dentifrice composition having the oral antimicrobial effect according to the present invention contains the herbal extract, especially the herbal extract, containing the lemon grass extract and / or the sancho extract, Activity. Particularly, in the case of containing only the sancho extract (Example 4), the absorption rate is lowered at a certain concentration or more. However, in the case of containing other herb extracts including the sancho extract (Example 5) And showed high antimicrobial activity with low standard deviation and no degradation.

Experimental Example 2: Sensory evaluation

A questionnaire survey was conducted from January 14 to January 16, 2015, and 273 questionnaires were used for analysis to collect basic data for the development of natural birds toothpaste and to collect various opinions of consumers.

In the case of sex, 69.6% of 'male' and 73.7% of 'female' were shown in toothpaste composition 7 (interest according to sex) according to the present invention.

division Interested be not interested in male 71 (69.6%) 31 (30.4%) female 126 (73.7%) 45 (26.3%)

In the case of the preference by age, as shown in Table 8 (interest according to age), '40s' was the most interested in the dentifrice composition according to the present invention at 79.8%.

division Interested be not interested in 20 or less 41 (66.1%) 21 (33.9%) 30s 65 (69.9%) 28 (30.1%) 40s 67 (79.8%) 17 (20.2%) More than 50 24 (72.7%) 9 (27.3%)

After the completion of the prototype of the dentifrice composition according to the present invention, a survey was conducted to grasp the responses of consumers and collect opinions. The survey period was conducted from January 26 to February 10, 2015 in Jeonju and Iksan, Korea. A total of 73 questionnaires were used for the analysis except for the questionnaires with unreliable responses. The satisfaction of the four dentifrice compositions according to the present invention was 3.99 (average) on a scale of 5, and the standard deviation was 0.92.

In particular, the sensory evaluation of the dentifrice compositions according to the present invention was performed on the satisfaction of different combinations of herbal extracts. As a result,

The combination of pine extract and sancho extract (mean: 3.81, standard deviation: 0.94)

The combination of lemon grass extract and sancho extract (average: 3.99, standard deviation: 0.89)

The combination of the spearmint extract and the sancho extract (mean: 3.56, standard deviation: 0.92) and

The combination of the four herbal extracts of Example 6 (mean: 3.73, standard deviation: 0.82)

The overall satisfaction of dentifrice composition containing AChE extract was higher than that of other herbal extracts, and there was no significant difference between AChE extract group and control group.

In addition, as shown above, as a result of analyzing the purchasing intention of the dentifrice compositions according to the present invention while varying the combination of herbal extracts,

In the combination of pine extract and acanthopanax senticosus extract, the number of persons who intend to purchase was 49 (percentage: 68.1%), 23 persons (percentage: 31.9%),

In the case of combination of lemon grass extract and sancho extract, the number of persons who intend to purchase was 57 (percent: 78.1%), 16 persons (percentage: 21.9%),

In the case of combination of spearmint extract and acantholipid extract, the number of persons who intend to purchase was 39 (percentage: 53.4%), 34 persons (percentage: 46.6%)

In the case of the combination of the four herbal extracts of Example 6, the number of persons who intend to purchase was 42 (percentage: 57.5%) and 31 persons (percentage: 42.5%

The number of people who showed intention to purchase was relatively higher than the number of people who did not.

As a result of the survey, the dentifrice compositions of Examples 5 and 6 among the four kinds of natural bird toothpastes showed excellent satisfaction and purchase intention, and satisfaction with sex, age, marital status, 6 was very good. Accordingly, when the dentifrice compositions according to the present invention, especially the dentifrice compositions according to Examples 5 and 6, are commercialized, it is considered that the sales ratio can be increased freely regardless of gender and age range, and dental caries can be prevented, It is expected to be used as a functional toothpaste with effective treatment for stomatitis and the like.

Although the present invention has been described on the basis of a dentifrice composition, those skilled in the art can apply the dentifrice as an oral product using oral care products such as mouthwash, chewing gum, It is expected to develop various products.

While the invention has been shown and described with reference to certain exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (2)

6 to 20% by weight of a herbal extract selected from the group consisting of Spearmint extract, Pine extract, Lemon grass extract, Acanthopanax extract, and a mixture of two or more thereof; 15 to 20% by weight of a surfactant; 15 to 20% by weight of abrasive; 0.5 to 1.5% by weight of a viscosity modifier; 15 to 20% by weight of a detergent; 1 to 5% by weight of at least one additive selected from the group consisting of preservatives, perfumes, coloring agents, sweeteners, antioxidants and antibacterial agents; And a wetting agent as a remaining amount. The method according to claim 1,
Wherein the dentifrice composition further comprises a herbal essential oil in an amount within a range of 0.5 to 2 parts by weight based on 100 parts by weight of the dentifrice composition.