KR101126279B1 - Composition of mixed essential oils which is effective for stop smoking and its utiliztion - Google Patents

Abstract

The present invention relates to a mixed essential oil composition and a method for preparing a smoking cessation aid using the same, which are excellent in suppressing smoking demands and smoking cessation effects, and more specifically, 25 to 35% by weight of begamot oil, 20 to 30% by weight of coriander oil, It provides a mixed essential oil composition containing 15 to 25% by weight of ginger oil, 5 to 20% by weight of orange oil, 5 to 20% by weight of lemon oil, a method for producing a toothpaste, spray, pipe-type non-smoking aid using the mixed essential oil composition. It is about.

The mixed essential oil composition of the present invention can obtain the smoking desire suppression effect and sedation, mental stability effect, tension relief and concentration improvement effect by the aroma scent, toothpaste, spray, pipe-type anti-smoking aid using the mixed essential oil composition By allowing the aroma component to be inhaled into the human body, it has no side effects compared to conventional non-smoking supplements such as nicotine patches, nicotine gum, smoking candles, etc. It is very safe, simple and easy to use, and has a high smoking success rate. Have.

Mixed essential oils, aromatherapy, non-smoking, toothpaste, spray, pipe

Description

Composition of mixed essential oils which is effective for stop smoking and its utiliztion}

The present invention relates to a mixed essential oils composition having excellent smoking desire suppression and anti-smoking effects and an anti-smoking aid using the same.

More specifically, it provides a mixed essential oil composition containing 25-35% by weight of vegan oil, 20-30% by weight of coriander oil, 15-25% by weight of ginger oil, 5-20% by weight of orange oil, 5-20% by weight of lemon oil In addition, the mixed essential oil composition of the present invention can obtain the smoking desire suppression effect and sedation, mental stability effect, tension relief and concentration improvement effect by the aroma.

In another aspect, the present invention provides a method for producing a toothpaste, spray, pipe-type non-smoking supplement using the mixed essential oil composition, these non-smoking supplements are aroma components can be inhaled by the human body, conventional nicotine patches, nicotine gum, Compared to smoking cessation products such as smoking aids, such as no side effects, very safe, simple and easy to use, while having a high smoking success rate is characterized.

[Document 1] Korea Patent Registration No. 10-0649552

[Document 2] Moon Yu-sun, Aromatherapy, Korean Journal of Family Medicine, Volume 25, no.4, 2004 p.413-418

Smoking is known to have a significant causal relationship with various cancers, including lung cancer, as well as cardiovascular, respiratory and some digestive diseases. Smoking is treated as a social issue not only for personal health but also for public health, and people who smoke are increasingly restricted.

As a result, many smokers want to quit smoking, and statistically, 60-70% of smokers want to quit smoking, but since they are addicted to nicotine, they feel withdrawal symptoms. The hard thing is the reality. Since the 1990s, a lot of research on smoking cessation has been conducted, and various kinds of smoking cessation products such as nicotine replacement therapy, non nicotine drug therapy (such as buprifion), smoking cessation needle, and cigarette smoking cessation aids are being released and the product market is continuously Growing.

The general mechanism of nicotine replacement therapy, which occupies the largest market, is to reduce smoking habits by taking nicotine-containing patches, gums, and sprays when smokers feel the need to smoke. Nicotine patches are the principle of absorbing a certain amount of nicotine through the skin. Depending on the amount of smoking and physical condition, starting at a high or low dose, the body maintains a constant nicotine concentration for 24 hours, and gradually reduces nicotine by using a patch for a long period of about 8 to 12 weeks. Nicotine gum is a small amount of 2 ~ 4mg compared to the patch at any time when there is a need to smoke when you have the advantage of relieving withdrawal symptoms. Nicotine gum is a principle of chewing slowly over about 1 hour, if you feel a little tingling, the gum is placed between the teeth and cheeks, so that it is absorbed into the oral mucosa.

However, nicotine patches may have side effects such as skin friction damage, nausea or vomiting, muscle pain, dizziness, increased heart rate, and sleep disorders.Since nicotine is continuously supplied through the skin, patches and cigarettes are applied. When smoked, nicotine levels in your body can rise dramatically, leading to death.

Also, in case of nicotine chewing gum, the nicotine concentration may increase rapidly if chewing too quickly, and chewing two or more gums at once may increase the amount of nicotine absorbed, which may be harmful to your health.If you chew gum, drink carbonated beverages or nicotine. Do not use sprays. It irritates the oral cavity and throat, and can cause a swollen jaw joint, and it is nauseous and tasteless, and has an increased heart rate.

Cigarette smoking, a cigarette-type smoking aid, is a smoking cessation method using the habit of smoking. The motivation for smokers to smoke is because of nicotine, but because they often enjoy the act of smoking itself, there is no nicotine in smoking cigarettes. Instead, they contain more tar and carbon monoxide than regular cigarettes. Therefore, if you smoke for a long time instead of cigarettes can harm your health. Quit smoking is suitable for those who want to quit smoking in a short period of time, and sometimes as a way to help when you can not stand smoking. The Korea Food and Drug Administration should make sure that the amount of tar and carbon monoxide in smoking cessation should not exceed 10 mg, and that nicotine should not be detected at all. The plan was reviewed.

As a non-nicotine drug therapy, cronidine, antidepressants and the like are used. Chronidine is an effective drug for the withdrawal of alcohol or drugs. It is effective in reducing the withdrawal symptoms and increases the long-term smoking cessation rate. Smoking is more common in depressive patients, and antidepressant drugs are prescribed as anti-smoking drugs because depression is more difficult in depression patients. There is lean and there is evidence that sustained release is more effective than nicotine replacement. However, further research is needed to determine the best use for smoking cessation, and antidepressants cannot be used as a primary option over nicotine supplementation due to serious side effects.

Aromatherapy (aromatherapy) is a kind of natural therapy that uses essential oil (essential oil), a plant-derived biochemical, is a part of the complementary alternative medicine. Aromatherapy is a treatment that helps to alleviate various health problems by using pure essential oils extracted from scented plants. Currently, aromatherapy is widely used for personal health care among the general population than in the medical community.

Traditionally, aromas have been used for thousands of years to aid in breathing, reduce mucous debris, heal wounds on small wounds and insects, promote relaxation and sleep, relieve pain, alleviate digestive problems, and reduce muscle pain. Essential oils used in aromatherapy are known around the world for about 300-400 varieties, but they have similar effects, and in practice there are about 50 to 60 oils commonly used in aromatherapy. Lavender, peppermint, chamomile, and rosemary Essential oils such as, eucalyptus, lemon, orange, vegamot, geranium, and betimer have been studied and used a lot.

The present invention is to solve the problems of the conventional anti-smoking supplements, and to reduce the side effects on the human body, and to reduce the nicotine withdrawal symptoms such as smoking inhibitory effect and tension, instability, concentration disorders excellent anti-smoking mixed oil The purpose is to provide a composition.

Still another object of the present invention is to provide a method for preparing a smoking cessation aid product that can increase the success rate of smoking cessation while using easily and conveniently in daily life using the mixed composition.

In order to achieve the above object, the present invention provides a mixed essential oil composition excellent in sedation, mental stability effect, tension relief and concentration improvement effect by applying aromatherapy (aromatherapy), which is a kind of alternative medicine therapy, specifically, Vega Nail oil 25 to 35%, coriander oil 20 to 30%, ginger oil 15 to 25%, orange oil 5 to 20%, lemon oil 5 to 20% by weight. The prepared essential oil composition is able to obtain the effect of suppressing smoking desire, as a nicotine withdrawal symptom which causes the failure to quit smoking, thereby improving the smoking cessation effect by alleviating tension, instability, concentration disorder, etc. .

Method for producing a smoking cessation aid product according to the present invention for achieving the above object includes a toothpaste, spray, pipe products using a mixed essential oil composition, can be used easily and conveniently in daily life, as well as anti-smoking effect dental and mental health It is characterized by the manufacture of smoking cessation aids, which can attain the maintenance effect at the same time.

The mixed essential oil composition of the present invention exhibits the effect of greatly increasing the smoking cessation effect by reducing the need for smoking and relieving nicotine withdrawal symptoms such as anxiety and anxiety. The mixed essential oil composition is a very safe substance having no toxicity and side effects to the human body because it uses the scent components extracted from natural products, there is an advantage that can solve the side effects disadvantages of conventional smoking cessation aids.

In addition, it can be applied as a non-smoking supplement in the form of toothpaste, spray, pipe, etc., which can be used easily and conveniently in daily life. There is also an effect to relieve nicotine withdrawal symptoms to increase the success rate of smoking.

Hereinafter, a preferred embodiment of the mixed essential oil composition and the smoking cessation aid product manufacturing method excellent in the anti-smoking effect according to the present invention will be described in detail. These examples are intended to illustrate the invention and the scope of the present invention is not limited only to these examples.

Example 1

Examples of the mixed essential oil composition excellent in anti-smoking effect according to the present invention 25-35% by weight of bergamot oil, 20-30% by weight of coriander oil, 15-25% by weight of ginger oil, 5-20% by weight of orange oil, lemon oil 5 It contains 20 weight%.

The components used in the mixed essential oil according to the present embodiment and the effects thereof are as follows.

Bergamot essential oil is an essential oil obtained by squeezing the fresh fruit peel of Bergamot Citrus bergamia (Fructaceae). It is a green or yellow-green oil with a refreshing aroma. Green is derived from chlorophyll. Specific gravity is 0.871 ～ 0.880 and is soluble in ethanol and glacial acetic acid. Main components are linalol acetate ester (30-45%) and limonene (40%), In addition, it contains a camphor, pinene, a nerol, a linalool, etc. It has a relaxing effect, is used as a odorant, has an insecticidal effect, and is used as a flavoring agent for candy and a flavoring agent for pomade.

Coriander essential oil is derived from the seeds of Coriandrum sativum , an annual herb of umbelliferae, such as carrots, and is one of the oldest herbs in the world. There is a cleansing effect, and the body releases toxins and wastes from body fluids, and is known to be effective for severe fatigue and headaches.

Ginger oil is an essential oil obtained by steam distillation of the roots of ginger ( Zingiber officinal Roscoe (Zingiberaceae)). It is a yellowish-brown transparent liquid with an unusual smell and an unusual taste. Due to its strong physical effects, it is widely used as an alleviator for food poisoning symptoms and menstrual cramps.It is widely used in aromatherapy by anticipating the effects on mental health that help to adapt and adapt to change and give change and flexibility to rigid thoughts. have.

Orange essential oil is extracted from the peel of orange ( Citrus sinensis ), contains a large amount of limonene, a monoterpen hydrocarbon, and a small amount of aldehyde. Orange oil has been used for a while, but oranges have been used for a long time because they are rich in vitamins, especially in Chinese pharmacies. The cool, sweet fragrance is used as a stress-relieving oil because it stabilizes and calms the mind without calming the mood. The vegetable properties used for skin care are known to be suitable for sensitive and sensitive skin with anticonvulsion and sedative functions. have.

Lemon essential oil is extracted from the skin of lemon (Citrus limon) by compression method and contains almost 60% of limonene, a type of monoterpen hydrocarbon. Lemon oil, which stimulates activity, is known as an oil that clears the mind and helps to challenge new things in emotions. It is effective in preventing infections of small bacteria and fungi, and in particular, it helps to breathe smoothly. It is known as an oil that helps blood circulation, so it is particularly effective for bronchitis. It is an oil that strengthens the heart organs and helps blood circulation. It is effective for low blood pressure, and it is also known as a good oil to be used for rheumatoid arthritis and cold hands and feet. It is also known as diet oil because it helps. It is also known to reduce cholesterol levels and reduce blood sugar levels, which is good for preventing adult diseases. It is also known as a good oil for basic immune organs because it stimulates the activity of white blood cells.

[Example 2]

An embodiment of a method for preparing a mixed essential oil composition having excellent anti-smoking effect according to the present invention is as follows. That is, (1) preparing vega mot oil, coriander oil, ginger oil, orange oil, lemon oil, citronella oil, and geranium oil prepared by the usual manufacturing method. (2) In a mixing tank equipped with a stirrer, while maintaining the temperature at 25 ~ 40 ℃ and stirring at 50 ~ 150 rpm, 25-35% by weight of bergamot oil, 20-30% by weight of coriander oil, 15-25% by weight of ginger oil , Orange oil 5-20% by weight, lemon oil 5-20% by weight in order. (3) Mix thoroughly with stirring in a mixing tank for 30 minutes to 2 hours. (4) The stirring was stopped and the lid of the mixing tank was closed and then stabilized for 2 hours while maintaining the temperature at 30 ° C. (5) The finished mixed essential oil is sealed and stored at room temperature, or immediately used for the manufacture of non-smoking auxiliary products.

In the preparation of mixed essential oils, the mixing ratio of each essential oil is the range which can express the best fragrance characteristics in the sensory test and the highest result in the smoking cessation test. If the blending ratio of each essential oil is exceeded or underperformed, the fragrance property is not good, so a sense of rejection occurs or cannot be used continuously, and the smoking cessation effect is significantly lowered.

Example 3

Examples of the non-smoking auxiliary product using the mixed essential oil composition excellent in the anti-smoking effect according to the present invention includes a toothpaste, a spray, a pipe product.

The method for producing a toothpaste type anti-smoking aid product having excellent smoking cessation effect according to the present invention is as follows. That is, as a general ingredient used in toothpaste, when the toothpaste is prepared by a conventional method by combining the following raw materials, the mixed essential oil addition ratio is preferably in the range of 0.5 to 10% (w / w).

-Abrasive: Removes plaque, tartar, etc. attached to teeth, and uses phosphate, calcium carbonate, silicic anhydride, aluminum hydroxide, etc.

-Foaming agent: It lowers the interfacial tension at the time of use due to the action of the blended surfactant, which enhances the cleaning effect of brushing, helps the dispersion and permeability of the blended medicinal agents, and enhances the effect. It aims to give a sense of sentimental stability and satisfaction when brushing in. SLS (sodium lauryl sulfate) is mainly used, and it is suitable for use in toothpaste because it does not precipitate in acidic, alkaline or hard water due to neutrality.

-Wetting agent: To give toothpaste moisture and cream, prevent toothpaste from solidifying by contact with air and use polyhydric alcohols such as glycerin, sorbitol, and propylene glycol which have a refreshing sweetness.

-Binder: To prevent separation of solid and liquid components of toothpaste, C.M.C (Carboxymethyl cellulose), gum arabic, sodium alginate, etc. are used.

-Medicinal ingredients: Even if you do not add any medicinal ingredients, the toothpaste based on the correct brushing will clean the inside of the oral cavity, preventing dental caries, preventing pustules, whitening teeth, preventing tartar deposition, and preventing bad breath. In particular, if you want to enhance these effects, the drug is selected according to the purpose.

1) Tooth decay prevention

① Hemorrhoid enhancer: Sodium monofluorophosphate (Fluoride ion prevents bacteria in the oral cavity from melting tooth enamel by corrosive acid and strengthens teeth by promoting calcium supply), sodium fluoride and tin fluoride

② fungicides: chlorhexidines, lauryl acid monoglycerides, sarcosine acyl esters, dodecyldi (aminoethyl) glycine, propolis

③ enzyme: dextranase, mutanase, aminoglucosidase, glucose oxidase

2) Antipyretic preventive: Allantoinchlorohydroxyaluminum (protects the oral mucosa, prevents gum inflammation, gingivitis, periodontitis, swelling and redness, and reduces pain of gum inflammation) Capronic acid (aminocaproic acid, which has high anti-bleeding and anti-inflammatory effects, prevents gum bleeding by excellent hemostatic action), tranexamic acid, hinoxol, lysozyme, vitamin E and its derivatives, and sodium chloride.

3) Teeth whitening agent: mainly by the action of abrasive, but used as an auxiliary. PEG-400, PEG-4000, polyvinylpyrrolidone, peroxides, etc.

4) Bad breath prevention agent: A fungicide deodorant is used. Chlorhexidines, sodium chlorophyllin, lecithin, herbs, cyclodextrins, grapefruit seed extract, tea extract

5) Tartar remover: It is known to have the effect of preventing and removing tartar formation. EHDP, sodium polyphosphate, zeolite, citric acid, trimethylene phosphonic acid, ethylenediaminetetramethylene phosphonic acid

6) Hypersensitivity inhibitors: potassium nitrate, zinc oxide-oigenol

-Spice: Cleans the mouth, refreshes the morning, suppresses the unpleasant smell in the mouth, and instills the habit of brushing with taste and aroma.

-Sweetener: Uses saccharin, stevioside, xylitol, etc., and reduces plaque formation, which is a bacterial film on the tooth surface, and prevents tooth decay.

-Other Ingredients: Preservatives to prevent alteration of colorants and toothpaste.

Example 4

The method for producing a spray-type smoking cessation aid product excellent in smoking cessation effect according to the present invention is as follows. That is, a solution containing 0.1 to 10% by weight of mixed essential oils, an appropriate amount of alcohol, and water is prepared, and then injected into a conventional spray container.

Spray-type non-smoking supplements injecting solutions containing mixed essential oils are sprayed into the air, and the mixed essential oil components are naturally inhaled into the human body to suppress the need for smoking and to relieve and stabilize mental anxiety caused by nicotine withdrawal symptoms. There is a characteristic that can increase the smoking cessation effect.

Example 5

Pipe-type smoking cessation aids excellent production method according to the present invention is as follows. That is, in manufacturing a case and a filter in the form of a cigarette commercialized as a conventional smoking cessation aid, the mixed essential oil is applied directly to the filter portion. At this time, the amount of the mixed essential oil is preferably 0.01 to 1 ml.

The pipe-type non-smoking auxiliary product in which the filter applied with the mixed essential oil is inserted therein can be used naturally when a person wants to smoke, and there is a characteristic of causing a desire to suppress smoking by inhalation of the mixed essential oil component.

[Experiment 1]

The clinical trials and results of the present invention are described below to verify the effect of reducing smoking desire when the toothpaste type anti-smoking supplement using the essential oil having excellent anti-smoking effects is described below.

Among the smokers working at the officetel building in Mok-dong, Seoul, we recruited volunteers who agreed to the purpose and purpose of the clinical trial and wanted to quit smoking. The decrease in the need for smoking and the amount of smoking per day and the amount of post-prandial smoking for toothpaste type non-smoking supplements were measured.

Subjects were first educated on how to quit smoking, explaining the behavioral therapy of smoking cessation and drug therapy of quitting smoking, and distributing educational materials. Subjects were randomly given the same method and the same toothpaste under the supervision of the chief examiner in the order in which they received the smoking cessation education. The test period was four weeks, and two toothpastes were directly delivered to the test subjects, and the precautions for side effects were educated. "Apply a proper amount to a toothbrush and brush your teeth by brushing for at least three minutes. Clean your teeth three times a day, especially after eating." Subjects filled out the average daily smoking and daily post-smoking after filling out the questionnaire before using toothpaste, and after the meal, wiped teeth with clinical toothpaste and checked the decrease in the need for smoking according to clinical toothpaste every week. Record the amount of smoking per day / postprandial smoking.

The results of statistical processing of the total smoking amount and postprandial smoking amount of the test subjects are shown in [Table 1]. The total daily smoking amount decreased by 69% compared to before the test after 4 weeks, and the 30-minute smoking after eating decreased by more than 85% after the test after 4 weeks.

[Table 1]

In addition, as a result of investigating the decrease in the need for smoking before and after the use of mixed essential oil toothpaste, 52.5% showed a significant improvement, as shown in [Table 2]. Could.

TABLE 2

[Experiment 2]

The clinical trials and results of the anti-smoking success when using the toothpaste type anti-smoking supplement using the mixed essential oil having excellent anti-smoking effect of the present invention will be described below.

Among the smokers working at the officetel building in Mok-dong, Seoul, we recruited volunteers who agreed to the purpose and purpose of the clinical trial and wanted to quit smoking. The smoking cessation rate in each group was measured by dividing into 10 groups using the toothpaste type non-smoking supplement and 10 control groups using the toothpaste added with the same amount of peppermint oil.

Subjects were first educated on how to quit smoking, explaining the behavioral therapy of smoking cessation and drug therapy of quitting smoking, and distributing educational materials. Subjects were randomly given the same method and the same toothpaste under the supervision of the chief examiner in the order in which they received the smoking cessation education. The test period was four weeks, and two toothpastes were directly delivered to the test subjects, and precautions for side effects were educated. The test subjects were instructed on the dosage and dosage as follows. "Apply a proper amount to a toothbrush and brush your teeth by brushing for at least three minutes. Clean your teeth three times a day, especially after eating." Subjects checked whether or not to quit smoking at weekly intervals using a carbon monoxide meter, and those who quit smoking for 4 weeks were determined to be successful.

The measured results of the number of individuals who quit smoking at intervals of one week in the test group and the control group are shown in [Table 3]. In the control group, 4 people stopped smoking for 2 weeks, and after 4 weeks, only 1 smoked successfully. On the other hand, in the test group, 7 people quit smoking for 2 weeks, and after 4 weeks, 5 people quit smoking and showed 50% success rate, which was very high compared to 10% of the control group.

[Table 3]

Claims (5)

It is effective in suppressing smoking desire and maintaining smoking cessation including 25-35% by weight of bergamot oil, 20-30% by weight of coriander oil, 15-25% by weight of ginger oil, 5-20% by weight of orange oil, and 5-20% by weight of lemon oil. Excellent mixed essential oil composition. The method of claim 1, A toothpaste type non-smoking auxiliary product containing 0.5 to 10% by weight of the mixed essential oil composition. The method of claim 1, A spray-type non-smoking auxiliary product containing 0.1 to 10% by weight of the mixed essential oil composition. The method of claim 1, A pipe-type non-smoking auxiliary product using a filter obtained by applying 0.01-1 ml of the mixed essential oil composition. (1) preparing vega mot oil, coriander oil, ginger oil, orange oil and lemon oil extracted by a conventional manufacturing method; (2) In a mixing tank equipped with a stirrer, while maintaining the temperature at 25 ~ 40 ℃, stirring at 100 ~ 150 rpm, 25-35% by weight of bergamot oil, 20-30% by weight of coriander oil, 15-25% by weight of ginger oil 5 to 20% by weight of orange oil, 5 to 20% by weight of lemon oil are added in order; (3) mixing thoroughly with stirring in a mixing tank for 30 minutes to 2 hours constantly; And (4) stopping the stirring and covering the lid of the mixing tank and stabilizing for 2 hours while maintaining the temperature at 30 ℃ Mixed essential oil manufacturing method excellent smoke-free effect comprising a.