KR101195618B1 - Composition of Toothpaste for NoSmoking With green laver and Method of Preparing thereof - Google Patents

Abstract

The present invention provides a toothpaste composition and a method of manufacturing the same which has anti-smoking, anti-inflammatory and antimicrobial properties against caries prevention, oral cavity and gum disease.

The present invention is 0.1 ~ 12.33% by weight and propolis extract of herbal powder consisting of 0.01 ~ 1.20% by weight of green powder, licorice, catechin, black beans, sessin, lettuce, peach, lotus, pomegranate, soothe with respect to the total weight of the toothpaste composition By adding 0.01 to 1.16% by weight, it is possible to prevent tooth decay, oral disease and gum disease as well as function as a smoking cessation aid to suppress smoking.

Non-smoking, Blue, Tooth, Toothpaste, Gum, Periodontal, Oral

Description

Composition of Toothpaste for NoSmoking With green laver and Method of Preparing}

The present invention relates to a smoking cessation-assisted toothpaste composition containing greens and a method for manufacturing the same. It relates to a type toothpaste composition and a method for producing the same.

It is well known that tobacco has been a favorite food for many years. Moreover, despite the medical evidence that various toxic substances and carcinogens such as nicotine, tar and carbon monoxide in cigarettes are acting as a cause of various diseases, the smoking age of women and young adolescents has recently been decreasing. Awareness of quitting smoking is being raised.

However, tobacco addiction caused by nicotine is often abandoned due to withdrawal even if smokers try to quit. Nicotine is an important psychoactive substance present in cigarettes and is classified as a drug because it causes opioid-like habitual addiction. About 25% of nicotine inhaled through tobacco is absorbed into the blood and, in about 7-9 seconds, reaches the brain and acts on the nervous system to excite sympathetic and parasympathetic nerves. The effect of nicotine reaches its climax within one minute after smoking, and specific action is taken to maintain the nicotine dose in the blood to regain this effect. This is to smoke one more cigarette, knowing that smoking is not good because of this addictive substance of cigarettes, and it is not easy to quit smoking, even if you quit smoking, the above-mentioned withdrawal phenomenon occurs, and withdrawal phenomenon is that smokers smoke It is the mental and physical symptoms that occur when you stop smoking after being addicted to nicotine in your stomach. Physical symptoms include headache, sneezing, sputum, constipation, diarrhea and vomiting, and mental symptoms include insomnia, anxiety, decreased concentration, and desire to smoke.

Types of smoking cessation aids to prevent such withdrawal symptoms include nicotine chewing gum, nicotine-containing skin adhesives, nicotine reduction pipes, commercial smoking cessation aids, but side effects such as skin inflammation, gastrointestinal disorders, nausea and headache In addition, there are domestic smoking No. 97-9806, Korean Publication No. 97-9805, Korean Patent No. 289111, and Korean Patent No. 274825 as non-smoking supplements. There is a difficulty in using only to use, and there is a problem also occurs when harming the human body.

Therefore, the object of the present invention was developed in the light of the above-mentioned research results, the convenience that makes it easy for anyone to use the toothpaste composition to suppress tobacco smoking and to add a herbal medicine to the toothpaste composition to be used at all times. To provide a smoke-free supplemental toothpaste composition and a method for preparing the same, which contains a greener that gives anti-inflammatory and antimicrobial activity against tooth decay, gums and oral disease while providing safety without any side effects to any smoker. All.

To achieve the above object, the non-smoking auxiliary toothpaste composition of the present invention is a toothpaste composition in which the purified water is added to the abrasive, foaming agent, wetting agent, caking agent, active ingredient, flavoring agent and preservative of claim 1, Add 0.01 ~ 1.20% by weight of green powder, 0.10 ~ 12.33% by weight of herbal powder consisting of licorice, catechin, black soybean, sessin, lettuce, peach, lotus, pomegranate, and soothe and propolis extract 0.01 ~ 1.16% by weight It is characterized in that the composition.

In addition, in order to achieve the above object, the method for preparing a non-smoking auxiliary toothpaste composition of the present invention, the abrasive, wetting agent, caking agent, active ingredient, preservative and green powder of claim 2 0.01 ~ 1.20% by weight, licorice, catechin, Addition of purified water to 0.10-12.33% by weight of herbal powder consisting of black beans, sessin, lettuce, peach, lotus, pomegranate, and propolis extract and 0.01-1.16% by weight of propolis, and then put into a stirred tank prepared for at least 1 hour 10 First mixing step of homogeneously mixing in a vacuum atmosphere of ^-3 Torr, secondary mixing step of homogeneously mixing with the primary mixture under such a high vacuum for at least 1 hour by adding a prepared blowing agent after the first mixing step, 2 After the secondary mixing step, the prepared flavoring agent is characterized in that it comprises a third mixing step of homogeneously mixing for at least one hour or more under a high vacuum of 10 ^-3 Torr.

The present invention has the effect of keeping the tobacco smoking to the toothpaste composition to be used at all times, along with the addition of a herbal medicine to make it easy for anyone to use, and also has no side effects on the human body even if any smokers use It has the effect of having a safety, and also has the effect of having a pharmacological function of anti-inflammatory and antibacterial action against caries, gums and oral diseases.

Hereinafter, a more preferred embodiment of the present invention will be described in detail.

The herbal dry powder added to the toothpaste of the present invention with a sweetening function and pharmacological action is obtained by the same method as in Reference Examples 1 to 9.

Reference Example 1

Licorice after pretreatment such as sorting, washing and drying is put into a grinder to obtain a powder having a particle size of 300 mesh or less using a screen having a scale of 300 mesh.

Reference Example 2

The catechin is also placed in a green tea leaf, which has undergone pretreatment such as selection, washing, and drying, in a grinder as in Reference Example 1, and then used a screen having a scale of 300 mesh to grind a grain size of 300 mesh or less. Powder is obtained.

Reference Example 3

Black beans are also obtained in the same manner as in Reference Example 1 to obtain a powder having a particle size of 300 mesh or less.

Reference Example 4

Blue powder is also obtained in the same manner as in Reference Example 1 to obtain a powder having a particle size of 300 mesh or less.

Reference Example 5

Sessin is the rhizome of the footwort, and this root stem is obtained in the same manner as in Reference Example 1 to obtain a powder having a particle size of 300 mesh or less.

 Reference Example 6

In the same manner as in Reference Example 1 above, the powder having a particle size of 300 mesh or less is obtained.

 Reference Example 7

Peach also obtains a powder having a particle size of 300 mesh or less in the same manner as in Reference Example 1.

 Reference Example 8

Lotus flower is also treated with lotus root of lotus as in Reference Example 1 to obtain a powder having a particle size of 300 mesh or less.

 Reference Example 9

Pomegranate is also subjected to a powder having a particle size of 300 mesh or less in the same manner as in Reference Example 1.

Reference Example 10

In addition, a powder having a particle size of 300 mesh or less is obtained in the same manner as in Reference Example 1.

Reference Example 11

Propolis is made by secretion (wax) of pollen and bee itself collected from the sap and flower of bee tree sap and flowers, and obtains a powder having a particle size of 300 mesh or less in the same manner as in Reference Example 1.

<Production Example>

<Step 1: Raw material primary mixing step>

The raw material of the toothpaste is prepared in advance by weighing as shown in Table 1 below.

Raw Material and Content of Toothpaste Composition Raw material Content (% by weight) abrasive
Silicon dioxide 10-18.00 Silica 1.0 ~ 7.40 Active ingredient

Triclosan 0.50-2.8 Allantoin 0.01-1.20 Sodium fluoride 0.28-1.86 Ethanol Extract 20.21-40.63 Protein 0.016-0.10 blowing agent Tlauryl Sulfate 0.15 ~ 2.10 Wetting agent Polyethylene glycol 0.12-0.41 Dissolbitol solution 10-25 Concentrated glycerin 1.10-3.90 Prepayment Carboxymethyl Cellulose Sodium 0.10-0.82 Hydroxyapatite 0.10 ~ 7.40 Preservative Sodium benzoate 0.01-0.20 Sweetener
Saccharin Sodium 0.01 ~ 0.14 Xylitol 0.01 ~ 0.18 Flavor
dl-menthol 0.01 ~ 0.10 Peppermint Oil 0.01 ~ 0.016 Herbal medicine






licorice 0.01-1.10 Green Tea Leaves (Catechin) 0.01 ~ 1.21 Black Beans 0.01-1.14 Blue 0.01-1.20 Sesin 0.01-1.30 Lettuce 0.01 ~ 1.21 peach 0.01 ~ 1.34 Lotus (Lotus Root) 0.01 ~ 1.22 Pomegranate 0.01 ~ 1.33 Soothe 0.01 ~ 1.12 Propolis Extract 0.01-1.16      Purified water Balance 100 total

The primary mixture is added to the weighing abrasive, wetting agent, caking additive, sweetener, medicinal ingredients and preservatives as purified water in the prepared stirred tank with purified water as shown in Table 1 and mixed homogeneously in a vacuum atmosphere of 10 ^-3 Torr for at least 1 hour. Conduct. The reason for the mixing in a vacuum atmosphere of 10 ⁻³ Torr is to homogeneously mix the raw materials.

The reason for adding the abrasive is to remove the plaque and tartar attached to the teeth to give the original gloss. Tooth enamel quality is 6 ~ 7, so the abrasive The particle | grains of hardness 3 or less which do not damage is used, and the particle diameter of an abrasive | polishing agent is a small thing of 1-20 micrometers. The content of the abrasives is limited in the above range so as not to damage the enamel of the tooth. When the abrasive is less than 1% by weight, it is impossible to remove jig, tartar, etc. attached to the tooth. On the contrary, exceeding 18% by weight may cause damage to the teeth.

The reason for the addition of the humectant is to give the toothpaste moisture and cream (Cream) phase to prevent the toothpaste from contact with the air to solidify. If the content of the humectant is less than 0.12% by weight, there is a concern that it is easily hardened when exposed to the air, on the contrary, if it exceeds 25% by weight, there is a risk of flowing too much liquid.

The binder is added to prevent the separation of the solid component (powdery drug, abrasive, etc.) and the liquid component (wetting agent, active ingredient, flavoring agent, etc.) added to the toothpaste. It is a component that enhances the stability of toothpaste, but the range of 0.10 to 7.40 wt% is preferable because it affects the dispersibility, foaming properties, and the like of the toothpaste in the oral cavity. In other words, if the binder is less than 0.10% by weight, there is a risk that the mixing of the solid and liquid components of the toothpaste is weakened and the stability is lowered. On the contrary, if the content of the binder is greater than 7.40%, the stability is good. , Foaming agents, wetting agents, preservatives, sweetening agents, flavoring agents and herbal medicines may weaken the function.

The reason for the addition of the sweetener is to give a refreshing feeling, and in particular, xylitol has a sweetening function, such as saccharin, while reducing plaque formation, which is a bacterial film on the tooth surface, thereby preventing caries. In particular, sweeteners act as a sweetening effect in the oral cavity to suppress smoking of smokers.

Therefore, if the addition of sweetener is less than 0.01% by weight, the toothpaste may be weakened. On the other hand, if the content exceeds 1.32% by weight, the freshness is good, but the added abrasives, active ingredients, foaming agents, wetting agents, binders, preservatives, flavoring agents, There exists a possibility of weakening the function of herbal medicines.

  The reason for the addition of the active ingredient is to prevent tooth decay, prevention of pustules, deposition of tartar, and prevention of bad breath. The triclosan and protein are used as a fungicide to prevent bad breath in the oral cavity, and allantoin protects the oral mucosa. Inflammation prevention, gingivitis, swelling and redness accompanying periodontitis, sodium fluoride to prevent tooth decay, ethanol extract (alcohol) is used to taste after brushing. Therefore, if the active ingredient is less than 0.01% by weight, there is a risk that the pharmacological function that exhibits the above-mentioned efficacy is lowered. Conversely, if the content exceeds 40.63% by weight, the active ingredient is good, but the abrasive, foaming agent, wetting agent, caking agent, There exists a possibility of weakening the functions of preservatives, sweeteners, flavoring agents and herbal medicines.

The preservative (preservative) is added to maintain the form without alteration of the toothpaste, if the addition of the preservative less than 0.01% by weight, there is a risk of deterioration of the toothpaste, on the contrary, the active ingredient, abrasive, There exists a possibility that the function of a foaming agent, a humectant, a caking additive, a sweetening agent, a flavoring agent, and a herbal medicine may be weakened.

<Step 2: Raw material secondary mixing step>

After the secondary mixing step, the secondary blowing agent is mixed with the primary mixture under high vacuum for at least 1 hour by adding a foaming agent weighed as described in Table 1 above. The addition of the blowing agent lowers the interfacial action to enhance the cleaning effect of the brushing and to increase the effect by helping to disperse and penetrate the blended medicinal agent, and also to give a sense of volume to the soft (bubble) of the foam due to the foamability This is to give a sense of stability and satisfaction when brushing. Therefore, if the content of the blowing agent is less than 0.15% by weight, there is a risk of weakening the efficacy as described above, on the contrary, if it exceeds 2.10% by weight, the components added together, ie, active ingredients, abrasives, wetting agents, binders, sweeteners, flavoring agents, There exists a possibility of weakening the function of a preservative and a herbal medicine.

 <Step 3: Raw material 3rd mixing step>

Laver powder, licorice, catechin, black soybean, sessin, lettuce, peach, lotus, pomegranate, soothe, which were weighed as described in Table 1 after the second mixing step, as well as flavoring agents obtained in Reference Examples 1 to 11, respectively. A third mixture of 0.11 to 13.33% by weight of the herbal powder made of propolis is homogeneously mixed for at least 1 hour at a high vacuum of 10 ^-3 Torr to perform a tertiary mixing to obtain a final non-smoking auxiliary pasty toothpaste composition. The toothpaste thus produced is packaged and sold in a unit such as a tube.

The reason for the addition of the flavoring agent in the above is to suppress the unpleasant odor in the oral cavity and to add it to give a fresh and refreshing mouth. Therefore, when the added amount is less than 0.01% by weight, there is a fear that the above functions and efficacy are weakened, on the contrary, when the added content exceeds 0.10% by weight, the ingredients added together, that is, the active ingredient, abrasive, wetting agent, spot There is a fear that the functions of payment, sweeteners, foaming agents, preservatives and herbal medicines are weakened.

The addition of the herbal medicine is a part of the toothpaste of the present invention as a part of the big pharmacological action such as prevention of tooth decay, gum and oral disease prevention as well as suppressing smoking by herbal ingredients. In other words, the addition of green powder, prepared as a reference example in herbal medicine, is a pharmacological action of 'methyl methionine', which is rich in greens, which weakens nicotine's toxicity and releases it out of the body, thereby releasing nicotine addiction. It has a function of suppressing smoking, and the chlorophyll-rich ingredient in the seaweed also helps to eliminate bad breath. Therefore, the reason why the addition of the seaweed powder is 0.01-1.20% by weight is to suppress the smoking function. The addition of less than 0.01% by weight prevents the suppression of smoking inhibition, which is a pharmacological ingredient of the seaweed, on the contrary, exceeds 1.20% by weight. If it is, as described in Table 1, it causes a decrease in the efficacy of the raw materials added together.

  In addition, the addition of the lettuce powder is intended to promote the release of nicotine accumulated in the body together with the greening and to perform a whitening function of eliminating bad breath and whitening the teeth. Abundant minerals (calcium, phosphorus, iron, sodium and potassium) in the lettuce can activate kidney function to help the body release waste products. Therefore, the addition of less than 0.01% by weight of the lettuce powder does not exhibit the pharmacological efficacy of the above-mentioned lettuce, on the contrary, if it exceeds 1.21% by weight, the factors that lower the efficacy of the raw materials added as described in Table 1 above do.

In addition, the reason for the addition of licorice powder prepared as the reference example is to allow the detoxification function of the toxins contained in the body due to smoking, in particular, it functions to discharge the harmful substances of tobacco accumulated in the body such as lettuce. . Therefore, if the addition of licorice is less than 0.01% by weight, there is a risk of weakening the detoxification, sterilization, anti-inflammatory effect, etc. On the contrary, if the content exceeds 1.10% by weight, as shown in Table 1, the efficacy of the added raw materials is reduced. .

The reason for the addition of the green tea leaf powder prepared as the reference example is that the catechin contained in the green tea, such as the lettuce and licorice, is added to have an antioxidant action to remove heavy metals or free radicals in the body, thereby preventing smoking. The catechins contained in green tea contain several hydroxyl groups (-OH) due to their component structure, so they have a strong detoxification effect by adsorption of heavy metals, toxic substances, and nicotine. In addition, the catechin component has a bactericidal function to prevent caries and bad breath. Therefore, if the amount of catechin is less than 0.01% by weight, there is a risk of weakening the pharmacological action as described above, on the contrary, if it exceeds 1.21% by weight, as shown in Table 1, there is a fear of lowering the efficacy of the raw materials added together.

The reason for the addition of the sessin powder prepared as in the reference example is that it is added as a natural raw material that has a sweetness in the oral cavity and a natural antibacterial effect. In addition to suppressing smoking, antibacterial action also prevents bad breath and oral disease. Therefore, if the amount of secinin is less than 0.01% by weight, there is a risk of weakening the pharmacological action as described above, on the contrary, if it exceeds 1.30% by weight, as shown in Table 1, there is a fear of reducing the efficacy of the raw materials added together.

In addition, the peach powder prepared as in the reference example is added for the toxin excretion and detoxification effect accumulated in the body due to smoking like the herbal medicines. In particular, the organic acid contained in the skin of the peach nicotine in the body To remove the detoxification function, polyphenols also act as an antibacterial action to prevent oral disease and gum disease. Therefore, if the amount of peach added is less than 0.01% by weight, there is a risk of weakening the pharmacological action as described above, on the contrary, if it exceeds 1.34% by weight, as shown in Table 1, the efficacy of the raw materials added together is lowered.

In addition, the lotus (lotus root) powder prepared as in the reference example is added for the detoxification action to remove the nicotine poison of tobacco accumulated in the smoker's body, such as the herbal medicine, the lotus root is' loemerin, It contains ingredients such as nuciferin and nornuciferin, and asparagine, arginine, tannin, resin, tyrosine, ascorbic acid, etc., and has a high effect on detoxifying effects such as nicotine. Therefore, if the amount of lotus added is less than 0.01% by weight, there is a risk of weakening the pharmacological action as described above, on the contrary, if it exceeds 1.22% by weight, as shown in Table 1 above, there is a fear of reducing the efficacy of the raw materials added together.

In addition, the pomegranate prepared as in the reference example is added to bring about the antioxidant effect in the body by promoting the metabolism by promoting blood circulation, this action is AHA (citric, malic, ascorbic acid) contained in pomegranate It is carried out by the components of the smokers to discharge the waste contained in the body gives a smoking control function. Therefore, if the amount of pomegranate is less than 0.01% by weight, there is a risk of weakening the pharmacological action as described above, on the contrary, if it exceeds 1.33% by weight, as shown in Table 1, there is a fear of lowering the efficacy of the raw materials added together.

In addition, the addition of soothing prepared as in the reference example is to add to the action of releasing nicotine accumulated in the body of smokers, vitamin C contained in the soothe washes nicotine and supplements the calcium released by tobacco It works. Therefore, if the amount of soothe is less than 0.01% by weight, there is a risk of weakening the pharmacological action as described above, on the contrary, if it exceeds 1.12% by weight, as shown in Table 1 above, there is a fear of lowering the efficacy of the raw materials added together.

In addition, the propolis extract prepared as in the reference example is added to the sweetness and flavor as well, the sweetening function is to maintain the sweetness in the mouth of smokers and the flavor (flavonoids) to maintain the flavor of the cigarette Suppresses smoking. Therefore, if the added amount of propolis is less than 0.01% by weight, there is a risk of weakening the pharmacological action as described above, on the contrary, if it exceeds 1.16% by weight, as shown in Table 1 above, there is a fear of lowering the efficacy of the raw materials added together.

<Examples>

Among the raw materials weighed as shown in Table 1, first, purified water was added to the abrasive, the humectant, the caking additive, the sweetener, the active ingredient, and the preservative, and then added to a previously prepared stirring tank to be homogeneously in a vacuum atmosphere of 10 ^-3 Torr for at least 1 hour. After the primary mixing, and then the blowing agent weighed as shown in Table 1 was added to the secondary mixture homogeneously with the primary mixture under a high vacuum as described above for more than 1 hour, and finally the flavoring agent weighed as shown in Table 1 In addition, 0.11-13.33% by weight of herbal powder consisting of green powder, licorice, catechin, black soybean, sessin, lettuce, peach, lotus, pomegranate, soothe, and propolis obtained in Reference Examples 1 to 11 was added to a high concentration of 10 ^-3 Torr. Tertiary mixing, which was homogeneously mixed at least 1 hour under vacuum, was carried out to obtain a dentifrice composition.

Experimental Example 1

Heavy metal test results for the toothpaste obtained in the above Example were as shown in Table 2.

Test Items Specification value Remarks 1. Appearance

2.pH (stock solution)
3.heavy metal

4.Microorganisms Light yellow clear liquid, slight specific odor caused by herbal medicine.
5.0 ± 1
Lead: 20ppm or less
Arsenic: 2 ppm or less
100 colony / g or less Confirm


No detection.
No detection.
No detection.

Experimental Example 2

After the toothpaste obtained in the above example was used to test whether the 'smoking desire' and 'withdrawal phenomenon' were alleviated, the results were as shown in Table 3 below.

The test method allowed 30 smokers who had no smoking experience to quit smoking and brush their teeth using the anti-smoking assistive toothpaste of the present invention within 3 minutes after eating for 3 weeks, and then asked the users to feel the feelings through the questionnaire. Thirty subjects were analyzed using the 5-point scale method. The questionnaire items were whether there was a desire to smoke after brushing teeth and whether there was psychological stress such as anxiety and tension. As a result, as shown in Table 3, the testers using the smoking cessation assistive toothpaste of the present invention was confirmed that the withdrawal phenomenon such as smoking desire, anxiety and tension than the previous quit smoking. The score in Table 3 represents the average of the sum of the scores of the survey respondents.

Survey item score Desire for smoking 2.0 Withdrawal 3.1

* 5 points: Very large, 4 points: Large, 3 points: Normal, 2 points: Small, 1 point: Very small.

Experimental Example 3

The toothpaste obtained in the above example was allowed to be used by smokers, and then the tobacco taste was measured. Test method was carried out in the same manner as in Experiment 2 after 30 smokers to quit smoking. Then, the investigator was allowed to smoke the cigarette again, and then the questionnaire was compared to before using the toothpaste of the present invention compared to the cigarette taste that was normally smoked. As a result, as shown in Table 4, when using the smoking cessation assistive toothpaste of the present invention was confirmed that the tobacco taste.

division  Tobacco tastes poor equivalence Better Before use 13 10 7

As can be seen from Tables 3 and 4, in the case of using the non-smoking auxiliary toothpaste of the present invention, it is confirmed that it can function as a smoking cessation aid by reducing cigarette taste and alleviating withdrawal phenomenon and smoking desire due to smoking cessation. Could.

Experimental Example 4

50 adult men and women complaining or diagnosed symptoms such as periodontitis, toothache, bad breath, and tooth decay were continued to use the toothpaste obtained in the above example three times a day for 30 days, and the effect was evaluated by a questionnaire. The results are shown in Table 5 below.

Effect Determination Disease Nothing
effect effect
has exist considerable
effect Cure
effect system toothache 2 6 3 One 12 Periodontitis One 7 5 4 17 Bad breath 3 4 One 4 12 Caries prevention One 4 3 One 9 system 7 (14%) 21 (42%) 12 (24%) 10 (20%) 50 (100%)

As shown in the results of the experiment, toothpaste (89%), periodontitis (94%), bad breath (83%), and tooth decay prevention (75%) were alleviated when the toothpaste of the present invention was used steadily. Able to know.

<Experimental Example 5>

50 adult men and women were attached to the inner soft skin of the upper arm and the toothpaste prepared according to the above-described prescription of the present invention after 12 hours, the skin irritation, erythema, itching, allergies and the like. The results were shown in Table 6 below.

 Skin irritation % Of respondents  No change in skin  45 (90%) Slight itching after removal   2 (4%) The attachment area is slightly red but disappears after 1-2 hours   3 (6%)  Significant irritation   0 (0%)

Test results show that the toothpaste of the present invention does not irritate the skin.

Claims (2)

In a toothpaste composition in which purified water is added to an abrasive, a foaming agent, a humectant, a caking additive, an active ingredient, a flavoring agent, and a preservative, 0.01 ~ 1.20% by weight of green onion powder, xylitol, licorice, catechin, black soybean, sessin, lettuce, peach, lotus, pomegranate and soothe with respect to the total weight of toothpaste composition 0.10 ~ 12.35% by weight and propolis extract 0.01 ~ A smoking cessation assistive toothpaste composition containing a green flake added by adding 1.16% by weight. 1 to 18% by weight of abrasive, 0.12 to 25% by weight of wetting agent, 0.10 to 7.40% by weight of binder, 0.01 to 40.63% of active ingredient and 0.01 to 0.20% by weight of preservative, 0.01 to 1.20% by weight of green powder, xylitol, licorice, catechin , 0.10 ~ 12.35% by weight of herbal medicine powder consisting of black beans, sessin, lettuce, peach, lotus, pomegranate and 0.01% to 1.16% by weight of propolis extract, and then added to the stirred tank prepared for 1-5 hours A first mixing step of homogeneously mixing in a vacuum atmosphere of 10-3 Torr; A second mixing step of mixing homogeneously with the primary mixture under the high vacuum for 1 to 5 hours by adding 0.15 to 2.10 wt% of the prepared blowing agent after the first mixing step; And After the second mixing step of the prepared before-conjugated flavoring agent 0.01% to 0.10% by weight of the non-smoking auxiliary toothpaste composition containing the greening comprising a tertiary mixing step of homogeneously mixing for at least 1 to 5 hours at a high vacuum of 10-3 Torr Manufacturing method.