EP3484312A1 - A snuff-type composition and method and uses related thereto - Google Patents
A snuff-type composition and method and uses related theretoInfo
- Publication number
- EP3484312A1 EP3484312A1 EP17827056.7A EP17827056A EP3484312A1 EP 3484312 A1 EP3484312 A1 EP 3484312A1 EP 17827056 A EP17827056 A EP 17827056A EP 3484312 A1 EP3484312 A1 EP 3484312A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- nicotine
- snuff
- composition
- type composition
- linseed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/55—Linaceae (Flax family), e.g. Linum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/009—Sachets, pouches characterised by the material or function of the envelope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Definitions
- the snuff-type composition of the present invention may be utilized as such in the mouth or alternatively may be enclosed in a bag, pouch or membrane.
- said composition forms a solid mixture enclosed in a semipermeable membrane bag.
- said composition is enclosed in a porous membrane material that penetrates saliva and nicotine of the composition.
- said composition is to be administered to the mucosa of the mouth in or from a cellulose-containing membrane bag or directly e.g. from the applicator.
- a membrane bag material e.g. semipermeable fiber cellulose (e.g. commercially produced), is utilized for enclosing the snuff-type composition.
- a method for preparing or manufacturing a snuff-type composition comprises the following steps: providing linseed and nicotine, grinding linseed, adding water to linseed or nicotine or a mixture thereof e.g. under stirring to form a mixture comprising linseed, nicotine and water.
- the steps of grinding may take place either before or after providing linseed and nicotine.
- Water may be added before, after or both before and after grinding.
- linseeds are ground or crushed with pharmaceutically acceptable methods or methods acceptable in food industry.
- linseed or linseed crush is ground to a grain size selected from the group consisting of grain size between 0.001 - 10 mm, between 0.005 - 5 mm, between 0.01 - 4 mm, between 0.02 and 3 mm and between 0.03 - 2 mm.
- sieving is utilized after grinding. Said sieving can be carried out e.g. by sieving the crushed material through a sieve having suitable grain size.
- heating of the snuff-type composition is utilized to kill harmful germs or pathogens.
- the temperature may be held at about 70-100° C, in another embodiment about 1 to 30 hours, e.g. about 8-15 hours.
- Heating of the snuff-type composition is followed by a cooling step.
- the method comprises a cooling step wherein the tern- perature is cooled down to 15-30° C, e.g. about 20-25° C.
- flavors and/or possibly additional additives are added to the cooled blend.
- heating and cooling steps are not needed in the method of preparing a snuff-type composition.
- Example 1 A method of preparing a snuff-type composition
- the snuff-type composition prepared in example 1 B or 1 C was applied to the membrane bag.
- Membrane bag material was a commercially produced semi- permeable fiber cellulose, which allows the release of nicotine to saliva and into the oral cavity.
- the desired amount of the snuff-type composition was applied to the fiber cellulose bag so that the snuff-type composition dosed in the membrane bag contained either 2 or 4 milligrams of nicotine.
- the cellulose fiber bag was closed, for example, with hot iron using either machine or hand.
- the total length of the cellulose bag containing the snuff-type composition may vary, for example, from 10 to 30 mm, a width from 10 to 15 mm, and a thickness from 3 to 8 mm depending on the desired final bag size and nicotine content.
- composition in a fiber-cellulose bag released at least about 20%, at least about 30%, at least about 40% or more of the total content of nicotine within 30 minutes when subjected to said in vitro dissolution test.
- Example 3 Use of a snuff-type composition of the present invention
- Example 1 The products of Example 1 were tested. It was found out that the feeling of the composition in the mouth was pleasant, palatability was good, and the product was appropriately solid under the influence of saliva. The product was of the right size and the taste with different flavors was pleasant. According to the tobacco smokers (subjects smoking tobacco regularly) the snuff-type product was able to eliminate craving for a cigarette, prevent nicotine addiction and furthermore the snuff-type product committed to nicotine substitution treatment instead of smoking.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Addiction (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20160181A FI127620B (en) | 2016-07-12 | 2016-07-12 | Snuff-type composition of nicotine and crushed linseed |
PCT/FI2017/050531 WO2018011470A1 (en) | 2016-07-12 | 2017-07-11 | A snuff-type composition and method and uses related thereto |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3484312A1 true EP3484312A1 (en) | 2019-05-22 |
EP3484312A4 EP3484312A4 (en) | 2020-03-11 |
Family
ID=60952821
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17827056.7A Withdrawn EP3484312A4 (en) | 2016-07-12 | 2017-07-11 | A snuff-type composition and method and uses related thereto |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP3484312A4 (en) |
FI (1) | FI127620B (en) |
WO (1) | WO2018011470A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK180339B1 (en) | 2019-06-07 | 2020-12-18 | Ncp Nextgen As | Nicotine pouch composition and pouch comprising such |
EP3773494B1 (en) | 2019-06-07 | 2022-04-06 | NCP NextGen A/S | Nicotine pouch composition and pouch comprising such |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5503844A (en) * | 1993-05-18 | 1996-04-02 | Mli Acquisition Corp. Ii | Foam laminate transdermal patch |
GB9605116D0 (en) * | 1996-03-07 | 1996-05-08 | British American Tobacco Co | Smokable filler material for smoking articles |
US5948433A (en) * | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
NZ530439A (en) * | 2001-04-20 | 2004-11-26 | Lavipharm Lab Inc | Intraoral delivery of nicotine for smoking cessation |
US20100247653A1 (en) * | 2006-04-11 | 2010-09-30 | Hans Lautenschlager | Nanoparticles containing nicotine and/or cotinine, dispersions, and use thereof |
US7726320B2 (en) * | 2006-10-18 | 2010-06-01 | R. J. Reynolds Tobacco Company | Tobacco-containing smoking article |
US8833378B2 (en) * | 2008-09-17 | 2014-09-16 | Niconovum Ab | Process for preparing snuff composition |
US10799548B2 (en) * | 2013-03-15 | 2020-10-13 | Altria Client Services Llc | Modifying taste and sensory irritation of smokeless tobacco and non-tobacco products |
US11771127B2 (en) * | 2013-10-03 | 2023-10-03 | Altria Client Services Llc | Chewable dissolvable nicotine tablet |
US20150230516A1 (en) * | 2014-02-18 | 2015-08-20 | Jeffrey Daniel Stewart | Composition For Herbal Moist Snuff |
-
2016
- 2016-07-12 FI FI20160181A patent/FI127620B/en active IP Right Grant
-
2017
- 2017-07-11 WO PCT/FI2017/050531 patent/WO2018011470A1/en unknown
- 2017-07-11 EP EP17827056.7A patent/EP3484312A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
FI127620B (en) | 2018-10-31 |
FI20160181A (en) | 2018-01-13 |
EP3484312A4 (en) | 2020-03-11 |
WO2018011470A1 (en) | 2018-01-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20190121 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20200207 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 9/14 20060101ALI20200203BHEP Ipc: A61K 9/00 20060101ALI20200203BHEP Ipc: A61K 36/55 20060101ALI20200203BHEP Ipc: A24B 13/00 20060101ALI20200203BHEP Ipc: A24B 15/16 20200101AFI20200203BHEP Ipc: A61K 31/465 20060101ALI20200203BHEP Ipc: A61P 25/34 20060101ALI20200203BHEP Ipc: A61K 47/46 20060101ALI20200203BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20200908 |