JP6463097B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition.

  Conventionally, in oral compositions, fatty acids and salts thereof are frequently used as components that can bring about a desired action. For example, in the dentifrice composition described in Patent Documents 1 and 2, fatty acid soaps such as sodium salts and potassium salts of naturally-occurring fatty acids are used as foaming agents and cleaning agents, and the toothpastes described in Patent Document 3 Etc., saturated fatty acids, branched fatty acids and the like are used as caries agents having antibacterial action.

  On the other hand, in the composition for oral cavity described in Patent Document 4, a fatty acid salt is blended as a tooth surface coating agent. In Patent Document 5, fatty acid soap is used as a tubule blocking agent together with a decoction by potassium ions such as potassium nitrate. Used together. Furthermore, Patent Document 6 discloses a composition for oral cavity that exhibits the effect of blocking dentinal tubules and reducing the symptoms of dentinal hypersensitivity by a salt formed from a fatty acid and a basic amino acid.

JP 49-85249 A JP 2009-40756 A JP-A-63-88123 JP 2000-103726 A Japanese translation of PCT publication No. 2004-506663 JP 2014-62066 A

  These fatty acids have the property of being easily precipitated and can bring about a characteristic fatty acid odor. However, if acid resistance can be imparted while enhancing adhesion to the tooth surface, resistance to decalcification due to caries is increased. It can be increased and a useful oral composition can be realized.

  However, in the techniques described in Patent Documents 1 to 3, there is a high risk that fatty acids will precipitate at room temperature, and it is difficult to improve adhesion to the tooth surface and acid resistance. In addition, in the composition for oral cavity described in Patent Documents 4 to 5, attention is not paid at all to precipitation of fatty acid, and depending on the form of the composition, not only precipitation but also solidification may occur. Even if it is a technique, there is a possibility that the composition may be discolored, and improvement is still required in order to sufficiently exhibit adhesion to the tooth surface and acid resistance.

  Therefore, the present invention relates to a composition for oral cavity that exhibits excellent acid resistance while maintaining good stability and feeling of use while using a fatty acid salt.

  Therefore, the present inventor has made various studies, and while using a specific amount of a fatty acid potassium salt obtained by setting a specific saturated fatty acid and a potassium compound in a specific molar ratio, the present inventors further contain a specific amount of sorbitol and water. And it discovered that the composition for oral cavity which can exhibit the outstanding acid resistance was obtained by controlling pH to a specific value.

That is, the present invention includes the following components (A) to (C):
(A) Fatty acid potassium salt obtained from a saturated fatty acid having 12 to 22 carbon atoms and a potassium compound 0.05 mass% or more and 1.2 mass% or less in terms of fatty acid (B) Sorbitol 5 mass% or more and 40 mass% or less (C) The saturated fatty acid containing water and used for obtaining the component (A) contains 70% by mass or more and 100% by mass or less of palmitic acid,
The molar ratio (potassium / saturated fatty acid) of potassium in the potassium compound used to obtain component (A) and saturated fatty acid used to obtain component (A) is more than 1 and 3 or less, and The present invention relates to an oral composition having a pH at 25 ° C. of 7 or more and less than 9.
The present invention also includes the following components (A) to (C):
(A) Fatty acid potassium salt obtained from a saturated fatty acid having 12 to 22 carbon atoms and a potassium compound 0.05 mass% or more and 1.2 mass% or less in terms of fatty acid (B) Sorbitol 5 mass% or more and 40 mass% or less (C) The saturated fatty acid containing water and used for obtaining the component (A) contains 70% by mass or more and 100% by mass or less of palmitic acid,
25. The molar ratio (potassium / saturated fatty acid) of potassium in the potassium compound used to obtain component (A) and saturated fatty acid used to obtain component (A) is more than 1 and 3 or less, and 25 The present invention relates to an acid resistance improver having a pH of 7 or more and less than 9.

  According to the composition for oral cavity of the present invention, it has excellent adhesion of fatty acids or salts thereof to the tooth surface, can exhibit high acid resistance, and also suppresses discoloration while maintaining a good taste. And can have good stability. Therefore, it is extremely useful as an acid resistance improver.

Hereinafter, the present invention will be described in detail.
In the composition for oral cavity of the present invention, a fatty acid potassium salt obtained from a saturated fatty acid having 12 to 22 carbon atoms and a potassium compound as a component (A) is 0.05% by mass or more and 1.2% by mass in terms of fatty acid. % Or less. By using such a fatty acid potassium salt in a specific amount, while preventing the pH from being increased more than necessary, the appearance and feeling of use due to precipitates and solidification are prevented from being reduced, while ensuring good flavor, the fatty acid or The adhesion of the salt to the tooth surface can be enhanced and excellent acid resistance can be imparted.

  A saturated fatty acid (hereinafter, also simply referred to as “saturated fatty acid”) used to obtain the fatty acid potassium salt of component (A) is a viewpoint that effectively improves acid resistance while exhibiting good adhesion to the tooth surface. Therefore, the carbon number is 12 or more, preferably 14 or more. In addition, the saturated fatty acid is a component (A) or a fatty acid salt such as fatty acid sodium (hereinafter referred to as “component (A) or fatty acid”, etc.) including the saturated fatty acid and the fatty acid sodium described later in the oral composition of the present invention. The number of carbon atoms is 22 or less, preferably 18 or less, and more preferably 16 or less, from the viewpoint of effectively suppressing the precipitation and solidification of the above.

  And the saturated fatty acid used in order to obtain the fatty acid potassium salt of a component (A) is good flavor (with a fatty odor, while effectively improving acid resistance, suppressing effectively precipitation of a component (A) or a fatty acid etc. From the viewpoint of ensuring a flavor without fatty acid odor mixed with bitter taste, or a taste without feeling uncomfortable mixed with other flavors such as fat odor and bitter taste or salty taste, it contains 70% by mass or more of palmitic acid, Preferably, 75% by mass or more, more preferably 80% by mass or more, further preferably 85% by mass or more, and from an industrial viewpoint, palmitic acid is contained by 100% by mass or less, preferably 100% by mass. Less than, more preferably 98% by mass or less.

  The saturated fatty acid may be a saturated fatty acid containing at least 70% by mass of palmitic acid. Palmitic acid may be used alone, and specifically, for example, Lunac P95 (96% by mass of palmitic acid, Kao Corporation) can be used. In addition, as the saturated fatty acid, for example, a mixture of one or more selected from lauric acid, myristic acid, stearic acid and the like and palmitic acid may be used, and precipitation of component (A) or fatty acid is effective. Good flavor (flavor without fatty acid odor mixed with fat smell and bitter taste, or flavor without fat smell and salty taste and other unpleasant tastes) ) Is preferably a saturated fatty acid containing one or two selected from myristic acid and stearic acid and palmitic acid. Specifically, for example, LUNAC P95 and LUNAC L98 (lauric acid 99 mass) %, Kao Corporation), LUNAC MY98 (myristic acid 99% by mass, palmitic acid 0.5% by mass, Kao Corporation), and purified stearic acid 750 It can be a mixture of (75 wt% stearic acid, palmitic acid 25% by weight) of one or more selected from a.

  Specific examples of the potassium compound used to obtain the fatty acid potassium salt of component (A) (hereinafter also simply referred to as “potassium compound”) include, for example, one kind selected from potassium hydroxide and potassium carbonate, There are two types, and such potassium compounds are potassium compounds other than potassium nitrate, potassium citrate, and potassium acetate. Especially, as a potassium compound used in order to obtain the fatty acid potassium salt of a component (A), it was excellent in the viewpoint which produces | generates the fatty acid potassium salt of a component (A) efficiently with the said saturated fatty acid, and the fatty acid potassium salt obtained. From the viewpoint of imparting acid resistance, potassium hydroxide is preferred.

  The total content of potassium nitrate, potassium citrate, and potassium acetate in the oral composition of the present invention is a viewpoint that does not inhibit the flavor, and further when the oral composition of the present invention contains a fragrance containing terpene alcohol described later. Even from the viewpoint of effectively suppressing bitterness, the composition for oral cavity of the present invention is preferably 0.15% by mass or less, more preferably 0.1% by mass or less, and still more preferably 0.01% by mass or less. In addition, from the viewpoint of preventing the precipitation of the component (A) or the fatty acid and ensuring the appearance and smoothness, these potassium nitrate, potassium citrate, and more than the potassium amount of the potassium compound used to obtain the component (A) It is preferable that the potassium amount of potassium acetate is small, and the molar concentration of these compounds is preferably less than 50% with respect to the molar concentration of potassium of the potassium compound used to obtain the component (A). More preferably, it is 35% or less, More preferably, it is 10% or less, More preferably, it is 5% or less.

  The molar ratio (potassium / saturated fatty acid) of potassium in the potassium compound used for obtaining the component (A), that is, potassium derived from the potassium compound, and the saturated fatty acid (component in the oral composition of the present invention ( A) From the viewpoint of effectively suppressing precipitation of fatty acids and the like, and from the viewpoint of improving acid resistance, it exceeds 1, preferably 1.05 or more, more preferably 1.1 or more, and even more preferably 1 .2 or more. Moreover, the molar ratio (potassium / saturated fatty acid) of the potassium derived from the above potassium compound and the above saturated fatty acid is a viewpoint that suppresses the pH from being increased more than necessary, and thus ensures a good flavor by suppressing harmfulness and taste. From the viewpoint of reducing the yellowing color, it is 3 or less, preferably 2.5 or less, more preferably 2.0 or less, and even more preferably 1.8 or less. And the molar ratio (potassium / saturated fatty acid) of the potassium derived from the potassium compound and the saturated fatty acid is more than 1 and 3 or less, preferably 1.05 to 2.5, more preferably 1.1. It is -2.0, More preferably, it is 1.2-1.8. In addition, the said unpleasant taste is the unpleasant taste with which the taste of the fatty-acid oil, bitterness, salty taste, etc. were mixed.

  In the present invention, the molar ratio means a molar concentration ratio, and the molar concentration means a value (mmol / kg) calculated from the mass of the component contained in 1 kg of the composition. . For example, when 0.5 mass% fatty acid is contained in the composition, the fatty acid is assumed to be contained in 5 parts by mass of 1000 parts by mass of the composition, that is, 5 / (1000 × molar mass of fatty acid). The molar concentration value (mmol / kg) is determined.

  The difference in molar concentration between the potassium derived from the potassium compound and the saturated fatty acid (potassium-saturated fatty acid) is preferably 0.02 mmol from the viewpoint of efficiently producing the component (A) and improving the acid resistance. / Kg or more, more preferably 0.05 mmol / kg or more, still more preferably 0.5 mmol / kg or more. In addition, the difference in molar concentration between the potassium compound-derived potassium and the saturated fatty acid (potassium-saturated fatty acid) effectively suppresses precipitation of the component (A) or fatty acid in the oral composition of the present invention, From the viewpoint of suppressing yellow discoloration and suppressing harm due to pH increase, it is preferably 3 mmol / kg or less, more preferably 2 mmol / kg or less, and even more preferably 1.5 mmol / kg or less. The difference in molar concentration between the potassium compound-derived potassium and the saturated fatty acid (potassium-saturated fatty acid) is preferably 0.02 to 3 mmol / kg, more preferably 0.05 to 2 mmol / kg. More preferably, it is 0.05-1.5 mmol / kg, More preferably, it is 0.5-1.5 mmol / kg.

The content of the fatty acid potassium salt of the component (A) is 0.05% by mass in terms of fatty acid in the oral composition of the present invention, from the viewpoint of improving the adhesion to the tooth surface and improving the acid resistance. It is above, Preferably it is 0.1 mass% or more, More preferably, it is 0.2 mass% or more, More preferably, it is 0.3 mass% or more. Moreover, content of the fatty acid potassium salt of a component (A) is the composition for oral cavity of this invention from a viewpoint which suppresses precipitation of a component (A) or a fatty acid, etc., and a viewpoint which suppresses the fall of a flavor or bitterness. It is 1.2 mass% or less in a fatty acid conversion amount inside, Preferably it is 1.0 mass% or less, More preferably, it is 0.7 mass%. And content of the fatty acid potassium salt of a component (A) is 0.05 mass% or more and 1.2 mass% or less in the oral cavity composition of this invention, Preferably it is 0.1 mass%, Preferably it is 0.1. It is -1.0 mass%, More preferably, it is 0.2-1.0 mass%, More preferably, it is 0.3-0.7 mass%.
In addition, the fatty acid potassium salt of the component (A) is a fatty acid potassium salt in the composition as long as the molar ratio (potassium / saturated fatty acid) is more than 1 and 3 or less as in the oral cavity composition of the present invention. It is assumed that the content of the fatty acid potassium salt of the component (A) is expressed in terms of fatty acid equivalent.

  The composition for oral cavity of this invention contains 5 mass% or more and 40 mass% or less of sorbitol as a component (B). This effectively suppresses the precipitation of the component (A) or fatty acid in the oral composition of the present invention, and suppresses the oily flavor of the component (A) to obtain a good flavor and a wetting effect. be able to. Content of a component (B) is 5 mass% or more in the composition for oral cavity of this invention from a viewpoint which suppresses precipitation of a component (A) or a fatty acid, and a viewpoint which ensures favorable flavor. , Preferably it is 10 mass% or more, More preferably, it is 12 mass% or more. The content of the component (B) is 40% by mass or less in the oral composition of the present invention from the viewpoint of effectively preventing the composition from yellowing due to the component (B). , Preferably it is 35 mass% or less. And content of a component (B) is 5-40 mass% in the composition for oral cavity of this invention, Preferably it is 10-40 mass%, More preferably, it is 12-35 mass. %.

  The composition for oral cavity of the present invention can contain other sugar alcohols and glycerin other than sorbitol. Examples of sugar alcohols other than sorbitol include one or more sugar alcohols selected from xylitol, erythritol, reduced palatinose, and mannitol. The content of sugar alcohol other than sorbitol is preferably 10% by mass or less, more preferably 7% by mass or less, further preferably 5% by mass or less, and further 2% by mass or less. It may be, or it may not contain.

  When the oral composition of the present invention contains glycerin, the content of glycerin is included in the oral composition of the present invention from the viewpoint of preventing a decrease in flavor or flavor due to the combined use of fatty acid or fatty acid salt and glycerin. In addition, it is preferably 5% by mass or less, more preferably 3% by mass or less, and further preferably 1% by mass or less, or it is preferable that glycerin is not substantially contained or glycerin is not blended.

  The mass ratio ((B) / (A)) between the component (B) and the fatty acid equivalent amount of the component (A) is preferably 10 or more from the viewpoint of preventing separation while ensuring good flavor. More preferably, it is 15 or more, More preferably, it is 20 or more, More preferably, it is 25 or more. Moreover, the mass ratio of the component (B) and the fatty acid equivalent amount of the component (A) is preferably 200 or less, more preferably 150 or less, from the viewpoint of maintaining a good flavor while ensuring excellent acid resistance. More preferably, it is 100 or less, More preferably, it is 80 or less. And mass ratio of the fatty acid conversion amount of a component (B) and a component (A) becomes like this. Preferably it is 10-200, More preferably, it is 15-150, More preferably, it is 20-100, More preferably Is 25-80.

  The composition for oral cavity of this invention contains the water of a component (C). Thereby, the component (A) can be well dissolved in the composition, and the adhesion of the component (A) to the tooth surface can be favorably promoted while sufficiently reaching every corner of the oral cavity. The content of the component (C) is preferably 20% by mass or more, more preferably 25% by mass or more, preferably 65% by mass or less, more preferably in the oral composition of the present invention. 60% by mass or less. And content of a component (C) becomes like this. Preferably it is 20-65 mass% in the composition for oral cavity of this invention, More preferably, it is 25-60 mass%. In addition, the oral composition of the present invention is preferably a dentifrice composition from the viewpoint of preventing precipitation of the component (A) or fatty acid, and from this viewpoint, the content of the component (C) is preferably It is 10 mass% or more, More preferably, it is 15 mass% or more, More preferably, it is 20 mass% or more, More preferably, it is 25 mass% or more, Preferably it is 60 mass% or less.

  The mass ratio ((C) / (A)) between the component (C) and the fatty acid equivalent amount of the component (A) is from the viewpoint of preventing separation while ensuring good usability and dispersibility in the oral cavity. , Preferably it is 20 or more, More preferably, it is 30 or more, More preferably, it is 40 or more, More preferably, it is 60 or more. Moreover, the mass ratio of the component (C) to the fatty acid equivalent amount of the component (A) is preferably 250 or less, more preferably 220 from the viewpoint of maintaining a good feeling of use while ensuring excellent acid resistance. Or less, more preferably 130 or less. And the mass ratio of the component (C) and the fatty acid conversion amount of a component (A) becomes like this. Preferably it is 20-250, More preferably, it is 30-220, More preferably, it is 40-130, More preferably Is 60-120.

  When a sodium ion supply compound is present in the oral composition of the present invention, the saturated fatty acid constituting the component (A) is solidified by the formation of fatty acid sodium by the sodium ions released from the compound, It is preferable to limit the content of the sodium ion supplying compound because fatty acid sodium may be precipitated. Examples of the sodium ion supply compound capable of producing such fatty acid sodium include sodium hydroxide, sodium malate, sodium acetate, sodium citrate, sodium lactate, sodium dihydrogen phosphate, and sodium hydroxide is more fatty acid sodium. Easy to generate. Moreover, it is preferable to restrict | limit the content of sodium chloride and sodium carbonate from the viewpoint of preventing thickening and solidification of the composition and from the viewpoint of flavor.

  The content of the sodium ion supply compound other than sodium chloride and sodium carbonate in the oral composition of the present invention avoids the formation of fatty acid sodium, prevents the solidification of the composition and the generation of precipitates, and is excellent. From the viewpoint of ensuring the development of acid resistance, the composition for oral cavity of the present invention is preferably 0.03% by mass or less, more preferably 0.02% by mass or less, and still more preferably 0.01% by mass. % Or less. In addition, sodium chloride and sodium carbonate may cause salt exchange with the fatty acid potassium in the produced component (A), and sodium chloride and sodium carbonate should not be used from the viewpoint of preventing thickening and solidification of the composition. The content of sodium chloride and sodium carbonate is preferably 3% by mass or less, more preferably 1% by mass or less, and further preferably 0.5% by mass in the oral composition of the present invention. % From the viewpoint of flavor, and preferably 0.1% by mass or less.

  The content of the fatty acid sodium in the oral composition of the present invention is preferably in the oral composition of the present invention from the viewpoint of preventing solidification of the composition or generation of precipitates and ensuring a smooth use feeling. It is 0.1 mass% or less, More preferably, it is 0.05 mass% or less, More preferably, it is 0.01 mass% or less, and it is still more preferable not to mix | blend fatty acid sodium.

  The content of the basic amino acid is preferably limited from the viewpoint of preventing yellowing of the composition, and the content of the basic amino acid is preferably 0.1% by mass in the oral composition of the present invention. Or less, more preferably 0.05% by mass or less, and still more preferably 0.01% by mass or less. Here, examples of basic amino acids include arginine, lysine, histidine, tryptophan and the like, and from the viewpoint of preventing yellowing of the composition of lysine, arginine, histidine, the total content thereof may be in the above range. preferable.

  The oral composition of the present invention is preferably a dentifrice composition, more preferably a toothpaste composition, from the viewpoint of suppressing the precipitation of the component (A) or fatty acid, and the viewpoint of suppressing yellowing. preferable. Such a dentifrice composition can preferably contain a binder, an abrasive, a sugar alcohol and a fragrance described below.

  Further, the composition for oral cavity of the present invention has a viewpoint of preventing the saturated fatty acid used for obtaining the component (A) from forming an insoluble metal salt in the composition before use, and foaming is reduced. From the viewpoint of preventing this, it is preferable to limit the content of the polyvalent metal measured by an ICP emission analysis method (ICP emission analysis apparatus: Optima 5300 DV, manufactured by Perkin Elmer). The content of the polyvalent metal is a molar ratio (polyvalent metal / fatty acid) with the saturated fatty acid, preferably less than 0.1 (less than 0.1-fold mol), more preferably 0.02 or less. Yes, more preferably 0.01 or less, and it is preferable that the polyvalent metal is not substantially contained. Examples of the polyvalent metal include magnesium, aluminum, calcium, iron, zinc, strontium and the like.

When the composition for oral cavity of the present invention is a dentifrice composition, it can contain an abrasive, but from the same viewpoint as the above polyvalent metal, dicalcium phosphate dihydrate containing these polyvalent metals. Products and anhydrides, abrasives selected from abrasives such as calcium pyrophosphate, calcium carbonate, alumina, aluminum hydroxide, magnesium acetate, dibasic magnesium phosphate, magnesium acetate, and tertiary magnesium phosphate, aluminum lactate, and hydroxy The apatite content in the oral composition of the present invention is preferably 1% by mass or less, more preferably 0.1% by mass or less, still more preferably 0.01% by mass or less. In particular, it is preferable not to contain the abrasive, aluminum lactate, and hydroxyapatite.
Further, the content in the case of containing an abrasive other than the abrasive containing the polyvalent metal is preferably 15% by mass or less, more preferably 12% by mass or less, and preferably 1% by mass or more. Yes, more preferably 3% by mass or more. Examples of such an abrasive include abrasive silica. Here, the abrasive silica refers to those having an oil absorption of 50 to 150 mL / 100 g, and the oil absorption represents the amount of oil that can be supported by silica, and the measuring method is JIS K5101-13-2 (2004). Specified by the amount of oil absorbed in the boiled sesame.

  Further, the content of adsorbents such as zeolite and activated carbon is preferably limited from the viewpoint of preventing a decrease in the effect of the present invention, and such content is preferably 0.001 in the oral composition of the present invention. It is preferably less than mass%, more preferably 0.0001 mass% or less, and substantially no adsorbent such as zeolite or activated carbon is preferably contained.

  The oral composition of the present invention can further contain a binder. Examples of the binder include sodium alginate, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, and guar gum. And one or more selected from sodium alginate, sodium carboxymethylcellulose, carrageenan, xanthan gum, and hydroxyethylcellulose are preferable. The content of the binder is preferably 0.2% by mass or more, more preferably 0.4% by mass or more, and preferably 2% by mass or less in the oral composition of the present invention. More preferably, it is 1.8 mass% or less.

  When the oral composition of the present invention is a toothpaste composition, it is preferable to use a thickening silica in combination with the binder. The thickening silica is silica having an oil absorption of 200 to 400 mL / 100 g. Here, the amount of oil absorption indicates the amount of oil that can be supported by silica, and the measuring method is specified by the amount of oil absorbed in the boiled sesame according to JIS K5101-13-2 (established in 2004). The content of the thickening silica is preferably 1 to 15% by mass, more preferably 1.5 to 10% by mass, and further preferably 2 to 8% by mass in the oral composition of the present invention. is there.

  The oral composition of the present invention is a nonionic surface active agent such as an anionic surfactant, polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, sorbitan fatty acid ester, etc., in addition to the above components, as long as the effects of the present invention are not impaired. Surfactants such as agents; sweeteners such as saccharin sodium and sclarol; fragrances; pH adjusting agents other than the above components (excluding potassium compounds and basic amino acids); dyes; Furthermore, other components such as a fluoride ion supply compound such as sodium fluoride and ammonium fluoride, and a fluoride such as sodium monofluorophosphate may be contained within a range not impairing the effects of the present invention.

  For example, as perfumes, peppermint oil, spearmint oil, cinnamon oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, sage clary oil, nutmeg oil, funnel oil, lemon oil, Orange oil, peppermint oil, cardamom oil, coriander oil, basil oil, mandarin oil, lime oil, lavender oil, rosemary oil, ginger oil, grapefruit oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil , Lemongrass oil, lemon balm oil, pimento berry oil, palmarosa oil, olibanum oil, pine needle oil, pettigren oil, neroli oil, rose oil, jasmine oil, and other fragrance ingredients processed from these natural fragrance ingredients Menthol, pretol, carvone, aneth , Cineol, methyl salicylate, synamic aldehyde, eugenol, 3-1 -menthoxypropane-1,2-diol, thymol, citronellyl acetate, linalool, linalyl acetate, geraniol, geranyl acetate, citronellol, limonene, menthone, menthyl Acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde, citral, pulegone, calbeetoacetate, anisaldehyde, benzaldehyde, camphor, lactone, ethyl acetate, ethyl butyrate, allylcyclohexylpropionate, methylanthranis Rate, ethylmethylphenylglycidate, vanillin, undecalactone, hexanal, butyl acetate, isoamyl acetate, hex Single-flavored ingredients such as diol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, and ethylthioacetate; strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor , Flavoring ingredients such as fruit mix flavors and tropical fruit flavors. Among these fragrances, the composition for oral cavity of the present invention preferably contains a fragrance containing terpene alcohol from the viewpoint of obtaining a fresh feeling of use while containing fatty acid potassium. Such terpene alcohol is preferably one or two selected from chain terpene alcohols such as linalool, linalyl acetate, geraniol, geranyl acetate, citronellol and citronellyl acetate, and cyclic terpene alcohols such as menthol, pretol and menthyl acetate. It is above, It is preferable to contain combining 1 type, or 2 or more types chosen from menthol and chain | strand-shaped terpene alcohol, and various essential oils containing these can also be used.

  When using a fragrance | flavor in the composition for oral cavity of this invention, content of this fragrance | flavor is preferably 0.3 mass% or more in the composition for oral cavity of this invention from a viewpoint of favorable flavor, More preferably Is 0.5% by mass or more, more preferably 0.8% by mass or more, and preferably 2% by mass or less, more preferably 1.5% by mass or less from the viewpoint of suppressing bitterness and irritation. is there. The total content of the cyclic terpene alcohol selected from menthol, pretol, and citronellyl acetate in the fragrance is preferably 30% by mass or more, more preferably 40% by mass or more in the fragrance from the viewpoint of good flavor. From the viewpoint of suppressing bitterness and irritation, it is preferably 70% by mass or less, and more preferably 60% by mass or less in the fragrance. In addition, the total content of chain terpene alcohol selected from linalool, linalyl acetate, geraniol, geranyl acetate, citronellol, citronellyl acetate in the fragrance is from the viewpoint of improving the flavor by combining with fragrance such as menthol. Among these, preferably 0.1% by mass or more, more preferably 0.2% by mass or more, and from the viewpoint of suppressing bitterness and irritation, preferably 5% by mass or less, more preferably Is 3% by mass or less, more preferably 2% by mass or less.

The pH at 25 ° C. of the composition for oral cavity of the present invention is 7 from the viewpoint of suppressing the precipitation of the component (A) or fatty acid, etc., maintaining good flavor while enhancing excellent usability while exhibiting excellent acid resistance. It is above, Preferably it is 7.2 or more, More preferably, it is 7.5 or more. Further, the pH at 25 ° C. of the oral composition of the present invention is less than 9, preferably 8.8 or less, from the viewpoint of preventing harmful effects and effectively suppressing yellowing of the composition. More preferably, it is 8.5 or less. And the pH in 25 degreeC of the composition for oral cavity of this invention is 7 or more and less than 9, Preferably it is 7.2-8.8, More preferably, it is 7.5-8.5.
In addition, pH of the composition for oral cavity of this invention is the value measured at 25 degreeC using the pH electrode, and when the composition for oral cavity of this invention is a dentifrice composition, ion-exchange water or distilled water Means a value measured after adjusting to an aqueous solution having a concentration of 10% by mass with purified water.

  The method for producing an oral composition of the present invention comprises a saturated fatty acid having 12 to 22 carbon atoms containing palmitic acid in an amount of 70% by mass to 100% by mass, a potassium compound, potassium in the potassium compound, and a saturated fatty acid. The molar ratio (potassium / saturated fatty acid) of 1 is added in an amount of more than 1 and 3 or less, and sorbitol with a content of 5% by mass to 40% by mass and water are added. This step preferably includes a step (1) of heating and mixing the mixed fatty acid 1 containing the saturated fatty acid, the potassium compound, the sorbitol of the component (B), and the water of the component (C), as necessary. Furthermore, a step (2) of obtaining a mixed solution 2 by blending the mixed solution 1 with a wetting agent such as polyethylene glycol or a binder and heating the mixture is provided. Moreover, when using powders, such as an abrasive | polishing agent, the temperature of the liquid mixture 2 is 30 degrees C or less, More preferably, it is 10-28 degreeC. Preferably, when using a fragrance | flavor, it is preferable to provide the process (4) which mix | blends a fragrance | flavor after obtaining a process (3). The heating temperature of the composition in step (1) and step (2) is preferably 40 ° C. or higher and 80 ° C. or lower, and preferably 50 ° C. or higher and 70 ° C. or lower. Moreover, the water of the component (C) mix | blended in a process (1) may mix | blend whole quantity by a process (1), and may mix | blend a part of component (C) water in a process (2). Furthermore, among sugar alcohols other than sorbitol, a sugar alcohol having a solubility in water at 20 ° C. of 40% or less selected from erythritol, reduced palatinose, and mannitol is blended in step (3) or step (4). It is preferable.

In relation to the embodiment described above, the present invention further discloses the following oral composition and its acid resistance improver.
[1] The following components (A) to (C):
(A) Fatty acid potassium salt obtained from a saturated fatty acid having 12 to 22 carbon atoms and a potassium compound 0.05 mass% or more and 1.2 mass% or less in terms of fatty acid (B) Sorbitol 5 mass% or more and 40 mass% or less (C) The saturated fatty acid containing water and used for obtaining the component (A) contains 70% by mass or more and 100% by mass or less of palmitic acid,
The molar ratio (potassium / saturated fatty acid) of potassium in the potassium compound used to obtain component (A) and saturated fatty acid used to obtain component (A) is more than 1 and 3 or less, and The composition for oral cavity whose pH in 25 degreeC is 7-9.
[2] The saturated fatty acid used for obtaining the fatty acid potassium salt of component (A) preferably has 14 or more carbon atoms, preferably 18 or less, more preferably 16 or less. Oral composition.
[3] The saturated fatty acid used to obtain the fatty acid potassium salt of component (A) preferably contains 75% by mass or more of palmitic acid, more preferably 80% by mass or more, and further preferably 85% by mass or more. It contains, Preferably it contains less than 100 mass%, More preferably, the composition for oral cavity of said [1] or [2] which contains 98 mass% or less.
[4] The saturated fatty acid used to obtain the fatty acid potassium salt of component (A) is preferably one kind of palmitic acid alone, or preferably one kind selected from lauric acid, myristic acid, stearic acid and the like Or the composition for oral cavity of any one of said [1]-[3] which is a mixture of 2 or more types and palmitic acid.

[5] The potassium compound used to obtain the fatty acid potassium salt of component (A) is one or more selected from potassium hydroxide and potassium carbonate, and potassium nitrate, potassium citrate, and potassium acetate The composition for oral cavity according to any one of the above [1] to [4], which is a potassium compound other than the above, preferably potassium hydroxide.
[6] The total content of potassium nitrate, potassium citrate, and potassium acetate is preferably 0.2% by mass or less, more preferably 0.1% by mass or less, and further preferably 0.05% by mass or less. The composition for oral cavity according to any one of the above [1] to [5].
[7] The molar ratio (potassium / saturated fatty acid) of potassium in the potassium compound used to obtain component (A) and saturated fatty acid used to obtain component (A) is preferably 1.05 or more. More preferably, it is 1.1 or more, More preferably, it is 1.2 or more, Preferably it is 2.5 or less, More preferably, it is 2.0 or less, More preferably, it is 1.8 or less A composition for oral cavity according to any one of the above [1] to [6].
[8] The molar concentration difference (potassium-saturated fatty acid) between potassium in the potassium compound used for obtaining component (A) and the saturated fatty acid used for obtaining component (A) is preferably 0.8. 02 mmol / kg or more, more preferably 0.05 mmol / kg or more, further preferably 0.5 mmol / kg or more, preferably 3 mmol / kg or less, more preferably 2 mmol / kg or less, More preferably, the composition for oral cavity according to any one of the above [1] to [7], which is 1.5 mmol / kg or less.
[9] The content of the fatty acid potassium salt of the component (A) is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, and further preferably 0.3% in terms of fatty acid equivalent. The composition for oral cavity according to any one of the above [1] to [8], which is not less than mass%, preferably not more than 1.0 mass%, and more preferably 0.7 mass%.

[10] The content of the sorbitol as the component (B) is preferably 10% by mass or more, more preferably 12% by mass or more, and preferably 35% by mass or less. Or 1 oral composition.
[11] The content of sugar alcohol other than sorbitol is preferably 10% by mass or less, more preferably 7% by mass or less, further preferably 5% by mass or less, and further 2% by mass or less. The composition for oral cavity according to any one of the above [1] to [10], which may or may not be contained.
[12] The content of glycerin is preferably 5% by mass or less, more preferably 3% by mass or less, still more preferably 1% by mass or less, or substantially no glycerin is contained, or glycerin is contained. The oral composition according to any one of the above [1] to [11], which is preferably not blended.
[13] The mass ratio ((B) / (A)) between the component (B) and the fatty acid equivalent of the component (A) is preferably 10 or more, more preferably 15 or more, and still more preferably 20 Or more, more preferably 25 or more, preferably 200 or less, more preferably 150 or less, still more preferably 100 or less, and still more preferably 80 or less. 12] Any one composition for oral cavity.

[14] The water content of the component (C) is preferably 20% by mass or more, more preferably 25% by mass or more, preferably 65% by mass or less, more preferably 60% by mass or less. Yes, when the oral composition of the present invention is a dentifrice composition, it is preferably 10% by mass or more, more preferably 15% by mass or more, still more preferably 20% by mass or more, and even more. The composition for oral cavity according to any one of [1] to [13], which is preferably 25% by mass or more and preferably 60% by mass or less.
[15] The content of sodium ion supply compounds other than sodium chloride and sodium carbonate is preferably 0.03% by mass or less, more preferably 0.02% by mass or less, and still more preferably 0.01% by mass. The content of sodium chloride and sodium carbonate is preferably 3% by mass or less, more preferably 1% by mass or less, still more preferably 0.5% by mass or less, and preferably 0.8% or less. The composition for oral cavity according to any one of the above [1] to [14], which is 1% by mass or less.
[16] The content of fatty acid sodium is preferably 0.1% by mass or less, more preferably 0.05% by mass or less, still more preferably 0.01% by mass or less, and does not contain fatty acid sodium. More preferably, the composition for oral cavity according to any one of the above [1] to [15].
[17] The content of the basic amino acid is preferably 0.1% by mass or less, more preferably 0.05% by mass or less, and still more preferably 0.01% by mass or less. [16] The composition for oral cavity according to any one.
[18] The pH at 25 ° C. is preferably 7.2 or more, more preferably 7.5 or more, preferably 8.8 or less, more preferably 8.5 or less. [17] The composition for oral cavity of any one.
[19] The polyvalent metal content measured by ICP emission spectrometry is a molar ratio (polyvalent metal / saturated fatty acid) to saturated fatty acid used to obtain component (A), preferably less than 0.1 (Less than 0.1-fold mol), more preferably 0.02 or less, still more preferably 0.01 or less, and it is preferable that substantially no polyvalent metal measured by ICP emission spectrometry is contained. The composition for oral cavity according to any one of the above [1] to [18].
[20] Dicalcium phosphate dihydrate and anhydride containing polyvalent metals measured by ICP emission spectrometry, calcium pyrophosphate, calcium carbonate, alumina, aluminum hydroxide, magnesium acetate, dibasic magnesium phosphate, magnesium acetate The content of the abrasive selected from the abrasives of the third magnesium phosphate is preferably 1% by mass or less, more preferably 0.1% by mass or less, and further preferably 0.01% by mass or less. The composition for oral cavity according to any one of the above [1] to [19], which is preferably substantially free of these abrasives.

[21] A saturated fatty acid having 12 to 22 carbon atoms containing 70% by mass or more and 100% by mass or less of palmitic acid and a potassium compound, a molar ratio of potassium and saturated fatty acid in the potassium compound (potassium / saturated fatty acid) Any one of the above [1] to [20], comprising a step of blending sorbitol with a content of 5 to 40% by mass and water in an amount of more than 1 and 3 or less. A method for producing an oral composition.
[22] The step preferably comprises a step (1) of heating and mixing the mixed liquid 1 containing the saturated fatty acid, the potassium compound, the sorbitol of the component (B), and the water of the component (C), The production method of the above [21], comprising a step (2) of mixing the liquid mixture 1 with a wetting agent such as polyethylene glycol and a binder and mixing with heating to obtain the liquid mixture 2.
[23] The production method of the above [21] or [22], preferably comprising the step (3) of blending powder, and preferably comprising the step (4) of blending a fragrance after obtaining the step (3).

[24] The following components (A) to (C):
(A) Fatty acid potassium salt obtained from a saturated fatty acid having 12 to 22 carbon atoms and a potassium compound 0.05 mass% or more and 1.2 mass% or less in terms of fatty acid (B) Sorbitol 5 mass% or more and 40 mass% or less (C) The saturated fatty acid containing water and used for obtaining the component (A) contains 70% by mass or more and 100% by mass or less of palmitic acid,
25. The molar ratio (potassium / saturated fatty acid) of potassium in the potassium compound used to obtain component (A) and saturated fatty acid used to obtain component (A) is more than 1 and 3 or less, and 25 An acid resistance improver having a pH of 7 or more and less than 9.
[25] Use of the composition for oral cavity according to any one of [1] to [20] for improving the acid resistance of teeth.
[26] The composition for oral cavity according to any one of the above [1] to [20] for improving the acid resistance of teeth.
[27] Use of the composition for oral cavity according to any one of [1] to [20] for producing an acid resistance improver.

  Hereinafter, the present invention will be specifically described based on examples. In addition, unless otherwise indicated in a table | surface, content of each component shows the mass%.

[Examples 1-8, Comparative Examples 1-9]
In accordance with the formulation shown in Table 1, after fatty acid and potassium hydroxide, sorbitol aqueous solution, water, and sodium saccharin are heated and mixed at 60 ° C, polyethylene glycol, sodium carboxymethylcellulose, and sodium lauryl sulfate are blended at 60 ° C. After obtaining a mixed solution by heating and mixing, each dentifrice composition is prepared by blending powders such as silicic anhydride and titanium oxide after the mixed solution becomes 25 ° C. or less, and further blending and mixing a fragrance. I got a thing.
Each evaluation was performed according to the following method using the obtained composition.
The results are shown in Table 1.

<Evaluation of acid resistance>
Each dentifrice composition shown in Table 1 was evaluated. Specifically, 0.01 g of hydroxyapatite (HAp) powder (HAP-200, manufactured by Taihei Chemical Industry Co., Ltd.) is taken in a microtube (capacity 1.5 mL, manufactured by Eppendorf), and each toothpaste shown in Table 1 200 μL of a slurry solution obtained by diluting the composition 4 times with purified water was added and stirred for 10 minutes. After stirring, the supernatant was removed by centrifugation at 10000 rpm for 5 minutes. Next, 200 μL of purified water was added, and after stirring for 10 minutes, centrifugation was similarly performed, and the supernatant was removed and washed. Further, 1 mL of 0.1 M lactic acid (adjusted to pH 4.5 with sodium hydroxide) was added to the remaining powder, and after standing for 5 minutes, the entire amount was filtered with a 0.45 μm filter, and 500 μL of filtrate was taken. 500 μL of 2N hydrochloric acid was added.
Subsequently, the calcium ion eluted using calcium E-Test Wako (manufactured by Wako Pure Chemical Industries, Ltd.) was measured and used as the calcium elution amount.
The results are shown in Table 1.

<Measurement of pH>
Each obtained dentifrice composition was placed at 25 ° C. for 24 hours, adjusted to an aqueous solution having a concentration of 10% by mass with purified water at 25 ° C., and then the pH of the aqueous solution was measured using a pH electrode.

<< Appearance evaluation >>
Each of the obtained dentifrice compositions was stored at 25 ° C. for 24 hours and then visually observed according to the following criteria from the viewpoint of solidification, crystal precipitation, or change in the color of the composition. Evaluation was performed.
A: Precipitation of fatty acid of component (A), separation of composition, and solidification of composition were not observed, and no discoloration was observed. B: Deposition of fatty acid of component (A), separation of composition, and composition Although no solidification was observed, discoloration was observed (discolored to yellow)
C: Precipitation of fatty acid of component (A) (C: precipitation), separation of composition (C: separation), or solidification of composition (C: solidification) was observed, and discoloration was also observed.

<Evaluation method of flavor>
For each dentifrice composition shown in Table 1, brushing 1 g of the dentifrice composition using a toothbrush (Deep Clean Ultra Compact Normal / Kao Co., Ltd.) for 2 minutes, then spitting it out and rinsing the mouth with water, according to the following criteria Evaluation was performed by three panelists.
In addition, evaluation of flavor shows the common evaluation of 2 or more out of 3 persons in Table 1.
A: Fatty odor and saltiness were not felt B: A little fat odor was felt (B-1), or a slightly mixed taste of saltiness and bitterness was felt (B-2)
C: A fatty odor was felt (C-1), or a nasty taste in which salty taste and bitter taste were promoted each other (C-2)
D: Cannot be applied to the oral cavity or very bitter 2 minutes brushing was painful

※１：ラウリン酸９９質量％、花王株式会社
※２：ミリスチン酸９９質量％、パルミチン酸０．５質量％、花王株式会社
※３：パルミチン酸９６質量％、花王株式会社
※４：ステアリン酸７５質量％、パルミチン酸２５質量％、花王株式会社
※５：表２に記載の香料

* 1: Lauric acid 99% by mass, Kao Corporation * 2: Myristic acid 99% by mass, palmitic acid 0.5% by mass, Kao Corporation * 3: Palmitic acid 96% by mass, Kao Corporation * 4: Stearic acid 75 % By mass, 25% by mass palmitic acid, Kao Corporation * 5: Perfumes listed in Table 2

  As shown in Table 1, in Comparative Examples 1 to 9, solidification, separation, or discoloration was observed in the appearance, the acid resistance was insufficient, or the taste was very bad. In Examples 1 to 8, the content of palmitic acid in the saturated fatty acid is sufficiently high, the potassium hydroxide is sufficiently contained in the saturated fatty acid, and the sorbitol is appropriately contained. The evaluation was a good appearance with no yellowing or the like, acid resistance to suppress calcium elution even under acidic conditions, and a generally good flavor.

[Examples 9 to 10]
In accordance with the formulation shown in Table 3, each dentifrice composition was obtained in the same manner as in Example 1.
Each evaluation was performed according to the said method using the obtained composition.
The results are shown in Table 3.

※１〜４：表１と同じ
※６：表４に記載の香料
※７：表５に記載の香料

* 1-4: Same as Table 1 * 6: Fragrance listed in Table 4 * 7: Fragrance listed in Table 5

  As shown in Table 3, all of Examples 9 to 10 were dentifrice compositions exhibiting excellent effects equivalent to Example 1.

Claims (7)

The following components (A) to (C):
(A) Fatty acid potassium salt obtained from a saturated fatty acid having 12 to 22 carbon atoms and a potassium compound 0.05 mass% or more and 1.2 mass% or less in terms of fatty acid (B) Sorbitol 5 mass% or more and 40 mass% or less (C) The saturated fatty acid containing water and used for obtaining the component (A) contains 70% by mass or more and 100% by mass or less of palmitic acid,
Potassium potassium compound used for obtaining the component (A), the molar ratio of saturated fatty acid used to obtain the component (A) (potassium / saturated fatty acid) is 3 or less than 1, component The molar concentration difference between potassium in the potassium compound used to obtain (A) and the saturated fatty acid used to obtain component (A) is 0.02 mmol / kg or more and 3 mmol / kg or less, and The composition for oral cavity whose pH in 25 degreeC is 7-9. The composition for oral cavity according to claim 1 , wherein the content of the sodium ion supply compound is 0.03% by mass or less. The composition for oral cavity according to claim 1 or 2 , wherein the content of the basic amino acid is 0.1% by mass or less. The composition for oral cavity according to any one of claims 1 to 3 , wherein the potassium compound used for obtaining the component (A) is potassium hydroxide. The composition for oral cavity according to any one of claims 1 to 4 , wherein the total content of potassium nitrate, potassium citrate, and potassium acetate is 0.1% by mass or less. The following components (A) to (C):
(A) Fatty acid potassium salt obtained from a saturated fatty acid having 12 to 22 carbon atoms and a potassium compound 0.05 mass% or more and 1.2 mass% or less in terms of fatty acid (B) Sorbitol 5 mass% or more and 40 mass% or less (C) The saturated fatty acid containing water and used for obtaining the component (A) contains 70% by mass or more and 100% by mass or less of palmitic acid,
Potassium potassium compound used for obtaining the component (A), and the molar ratio of saturated fatty acid used to obtain the component (A) (potassium / saturated fatty acid) is less than 3 more than 1, component ( The difference in molar concentration between potassium in the potassium compound used to obtain A) and the saturated fatty acid used to obtain component (A) is 0.02 mmol / kg or more and 3 mmol / kg or less, and 25 An acid resistance improver having a pH of 7 or more and less than 9. A saturated fatty acid having 12 to 22 carbon atoms and containing 70% by mass or more and 100% by mass or less of palmitic acid, and a potassium compound, the molar ratio of potassium and saturated fatty acid in the potassium compound (potassium / saturated fatty acid) is 1. More than 3 and less than 3 and the difference in molar concentration between potassium and saturated fatty acid in the potassium compound is 0.02 mmol / kg or more and 3 mmol / kg or less , and 5 mass% or more and 40 mass% or less The manufacturing method of the composition for oral cavity of any one of Claims 1-5 provided with the process of mix | blending the quantity of sorbitol and water.