JP2003306416A - Toothpaste composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a toothpaste composition having an excellent external appearance (texture when kneaded) and intraoral dispersibility. <P>SOLUTION: This toothpaste composition contains (A) 1.0-50 wt.% of thickening agents in which 1.0-5.0 wt.% of polyethylene glycol having an average molecular weight of 100-600 is contained, (B) 0.4-0.8 wt.% of xanthan gum as a binder, and (C) 2.0-3.5 wt% of sodium lauryl sulfate as a surfactant. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a toothpaste composition having a good tooth appearance and excellent dispersibility in the oral cavity.

[0002]

2. Description of the Related Art Conventionally, the problems to be solved by the invention
As a toothpaste composition excellent in dispersibility in the oral cavity, a technique of blending a powder base that elutes divalent or higher valent metal ions, a cross-linking polyacrylic acid or a salt thereof, and xanthan gum as a binder (JP-A-61) No. 15826), a technique of using xanthan gum as a polishing agent and a binder in combination at a specific ratio with a polyacrylate salt (JP-A-10-17445),
Technology containing silica-based abrasive, binder containing xanthan gum and sodium polyacrylate in combination, thickener, water, fluorine compound to obtain specific viscosity and shear stress value (JP-A-10-45549) Has already been proposed.

However, although these toothpaste compositions have excellent dispersibility in the oral cavity, there is still room for improvement in terms of appearance (skin), and the development of a toothpaste composition of higher quality is desired. Be done.

The present invention has been made in view of the above circumstances.
It is an object of the present invention to provide a toothpaste composition having an excellent dry appearance and excellent dispersibility in the oral cavity.

[0005]

Means for Solving the Problems and Modes for Carrying Out the Invention As a result of intensive studies to achieve the above object, the present inventor found that the viscous agent was 1.0 to 50% (mass percentage, the same applies hereinafter).
In the toothpaste composition to be contained, polyethylene glycol having an average molecular weight of 100 to 600 as a thickening agent, xanthan gum and polyacrylic acid or a salt thereof as a binding agent, and sodium lauryl sulfate as a surfactant are blended in a specific blending ratio, respectively. By doing so, it is possible to unexpectedly disintegrate the toothpaste composition, and to provide high foamability, and to obtain a toothpaste composition having a smooth and excellent appearance of the kneading skin and excellent dispersibility in the oral cavity. Based on this finding, the present invention has been completed.

Therefore, the present invention contains (A) a thickener in a total amount of 1.0 to 50%, and a polyethylene glycol having an average molecular weight of 100 to 600 as a thickener in an amount of 1.0 to 50%.
5.0%, (B) 0.4 xanthan gum as a binder
~ 0.8% and polyacrylic acid or its salt 0.4 ~
There is provided a toothpaste composition comprising 1.0% and (C) 2.0-3.5% sodium lauryl sulfate as a surfactant.

The present invention will be described in more detail below. The toothpaste composition of the present invention comprises (A) a thickening agent having an average molecular weight of 1
100-600 polyethylene glycol, (B) xanthan gum as a binder and polyacrylic acid or a salt thereof,
(C) It contains sodium lauryl sulfate as a surfactant.

In this case, in the toothpaste composition of the present invention, the thickening agent is contained in the total amount (average molecular weight 100 to 60).
The total amount of polyethylene glycol of 0 and other thickening agents) is 1.0 to 50% of the total composition, preferably 20 to
30%. If the blending amount is too small, the kneading appearance will be poor, and if it is too large, the dispersibility in the oral cavity will be poor.

In the present invention, polyethylene glycol added as a thickening agent has an average molecular weight of 100 to 600,
It is preferably 300 to 400, and its amount is 1.0 to 5.0% of the total composition, preferably 2.0.
~ 4.0%. If the blending amount is too small, the kneading appearance will be poor, and if it is too large, the stability of toothpaste cannot be ensured.

On the other hand, examples of thickening agents other than polyethylene glycol having an average molecular weight of 100 to 600 include, for example, sorbit, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polypropylene glycol, xylitol, maltitol and lactitol. 1 type or 2 types or more of these etc. can be mix | blended.

The amount of xanthan gum as a binder is 0.4 to 0.8% of the total composition, preferably 0.5.
If the blending amount is too small, the stability of toothpaste cannot be secured, and if it is too large, the dispersibility in the oral cavity becomes poor.

The amount of polyacrylic acid or its salt compounded is 0.4 to 1.0% of the total composition, preferably 0.6.
If it is too small, the dispersibility in the oral cavity is poor, and if it is too large, the stability of toothpaste cannot be ensured.

The content of sodium lauryl sulfate as a surfactant is 2.0 to 3.5%, preferably 2.5 to 3.0% of the total composition. If the blending amount is too small, the dispersibility in the oral cavity is poor, and if it is too large, the stability of toothpaste cannot be secured.

The toothpaste composition of the present invention is prepared according to a conventional method by blending the above-mentioned components and, in addition, other appropriate components usually used. In this case, as the other components, components usually used in toothpaste compositions can be blended within a range that does not impair the effects of the present invention, and a binder other than the above components, a surfactant, further an abrasive, a sweetener. , Fragrances, antiseptics, various active ingredients and the like may be added.

For example, as the polishing agent, calcium hydrogen phosphate / anhydrous, calcium hydrogen phosphate / dihydrate,
Tertiary calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, silicic acid anhydride, aluminum silicate, insoluble sodium metaphosphate, third magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, zirconium silicate, polymethyl methacrylate, One kind or two or more kinds of other synthetic resins may be blended. The content of the abrasive is 10 to 50%, especially 2
It is preferably 0 to 30%.

As the binder, carrageenan, cellulose derivatives such as sodium carboxymethyl cellulose, methyl cellulose and hydroxyethyl cellulose, alginic acid derivatives such as sodium alginate and propylene glycol alginate, gellan gum,
One or more kinds of gums such as tragacanth gum and karaya gum, synthetic binders such as polyvinyl alcohol, and inorganic binders such as silica gel, bee gum and laponite may be blended.

As the surface active agent, an anionic surface active agent, a nonionic surface active agent and an amphoteric surface active agent can be blended.

Examples of the anionic surfactant include sodium alkylsulfates other than sodium laurylsulfate such as sodium myristylsulfate, sodium N-acylsarcosinate such as sodium N-lauroylsarcosinate, sodium N-myristoylsarcosinate, and dodecylbenzenesulfone. N-acyl glutamate salts such as sodium acidate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, N-methyl-N-acyl taurine sodium, N-methyl-N-acyl alanine sodium, Sodium α-olefin sulfonate or the like is used.

Examples of the nonionic surfactant include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, sugar alcohol fatty acid ester such as maltitol fatty acid ester and lactitol fatty acid ester, and polyoxyethylene sorbitan monolaur. Rate, polyoxyethylene sorbitan monostearate and other polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil and other polyoxyethylene fatty acid esters, lauric acid mono- or diethanolamide, myristic acid mono- or diethanolamide fatty acid mono or Diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxy Etc. Ji Ren polyoxypropylene fatty acid ester is used.

As the fragrance component, menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, cineol, linalool, ethyl linalool, vanillin, thymol, peppermint oil, spearmint oil, wintergreen oil, Fragrances such as clove oil and eucalyptus oil may be blended alone or in combination.

As the sweetener, saccharin sodium,
Sweetening agents such as stevioside, dipotassium glycyrrhizinate, perillartine, thaumatin and the like may be added.

The active ingredients include fluorides such as sodium fluoride and sodium monofluorophosphate, enzymes such as dextranase, mutanase, lysozyme, amylase, protease and lytic enzyme, tranexamic acid, ε-aminocaproic acid, glycyrrhizic acid. Blended with one or more active ingredients such as dipotassium, glycyrrhetinic acid, bisabolol, chlorophyll, sodium chloride, water-soluble inorganic phosphate compound, isopropylmethylphenol, triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride. obtain.

In the present invention, anti-inflammatory agents and bactericidal agents are used as active ingredients, and anti-plasmin agents such as tranexamic acid and ε-aminocaproic acid are used as anti-inflammatory agents, and isopropyl methylphenol, triclosan, cetylpyridinium chloride are used as bactericidal agents. , Benzethonium chloride, and benzalkonium chloride are preferably blended, and these active ingredients can be quickly dispersed in the mouth to effectively impart the effect. The compounding amount of the anti-inflammatory agent and the bactericidal agent is usually 0.01 to 0.1%.

[0024]

The toothpaste composition of the present invention has a good kneading appearance and excellent dispersibility in the oral cavity.

[0025]

EXAMPLES The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In addition, in the following examples, the compounding percentage is a mass percentage. [Comparative Examples 1 to 3, Examples 1 to 6] Toothpaste compositions having the compositions shown in Table 1 below were prepared by a conventional method, and the appearance and dispersibility in the oral cavity were evaluated by the following methods. The results are shown in Table 1. Evaluation method (1) Fill a sample having a diameter of 5 mm into a container having a caliber of 5 mm, and apply about 1
g was taken out and visually evaluated according to the following criteria. ◯: Good Δ: Slightly bad: Poor (2) Dispersibility A sample of about 1 g was taken out on the toothbrush, brushed as usual, and the dispersibility of toothpaste was sensory evaluated according to the following criteria. A: Good dispersibility B: A little dispersibility
X: Poor dispersibility

[0026]

[Table 1]

When a toothpaste composition having the following composition was prepared, all of them had a smooth kneaded skin and excellent dispersibility in the oral cavity.

[Example 7] Polyethylene glycol (molecular weight 200) 3% Xanthan gum 0.6 Sodium polyacrylate 0.8 Sodium lauryl sulfate 2.5 Perfume 1 Tranexamic acid 0.05 Taurine 0.3 85% Glycerin 25 Abrasiveness Silica 20 Saccharin sodium 0.2 Purified water Total remaining 100%

[Example 8] Polyethylene glycol (molecular weight 200) 4% Xanthan gum 0.4 Sodium polyacrylate 0.7 Sodium lauryl sulfate 3.0 Tranexamic acid 0.05 Perfume 1 70% sorbit 30 Aluminum hydroxide 18 Saccharin sodium 0 .15 Purified water Total remaining 100%

Example 9 Polyethylene glycol (molecular weight 600) 4% Xanthan gum 0.5 Sodium polyacrylate 0.6 Sodium lauryl sulphate 3.3 ε-Aminocaproic acid 0.03 Sodium pyrophosphate 5 Perfume 1 70% Solbit 35 Calcium carbonate 25 Sodium saccharin 0.2 Purified water Total remaining 100%

Example 10 Polyethylene glycol (molecular weight 400) 2% Xanthan gum 0.4 Sodium polyacrylate 0.8 Sodium lauryl sulfate 2.4 ε-Aminocaproic acid 0.05 Sodium hydrogencarbonate 3 Sodium tripolyphosphate 6 Perfume 1 70% Sorbit 30 Calcium hydrogen phosphate 18 Saccharin sodium 0.15 Purified water Total remaining 100%

Example 11 Polyethylene glycol (molecular weight 300) 2.5% Xanthan gum 0.5 Sodium polyacrylate 0.8 Sodium lauryl sulfate 2.5 Tranexamic acid 0.05 Perfume 0.8 Sodium fluoride 0.2 85% glycerin 30 calcium carbonate 20 sodium saccharin 0.15 purified water residual total 100%

[Example 12] Polyethylene glycol (molecular weight 400) 2.5% Xanthan gum 0.6 Sodium polyacrylate 0.5 Sodium lauryl sulfate 2.5 ε-Aminocaproic acid 0.03 Cetylpyridinium chloride 0.03 Fluoride Sodium 0.2 Fragrance 1 70% Solbit 40 Abrasive silica 20 Saccharin sodium 0.2 Purified water Total remaining 100%

Example 13 Polyethylene glycol (molecular weight 500) 3% Xanthan gum 0.7 Sodium polyacrylate 0.7 Sodium lauryl sulfate 3 Tranexamic acid 0.05 Benzalkonium chloride 0.02 Sodium monofluorophosphate 0. 7 Fragrance 1.2 70% Sorbit 30 Aluminum hydroxide 30 Saccharin sodium 0.2 Purified water Total remaining 100%

[Example 14] Polyethylene glycol (molecular weight 300) 4% Xanthan gum 0.7 Sodium polyacrylate 0.6 Sodium lauryl sulfate 3.2 Benzethonium chloride 0.02 Perfume 1.2 70% sorbit 40 Aluminum hydroxide 20 Saccharin sodium 0.2 Purified water Residual total 100%

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Yasuhiko Ide             1-3-7 Honjo, Sumida-ku, Tokyo Rio             Within the corporation (72) Inventor Takashi Yamamoto             1-3-7 Honjo, Sumida-ku, Tokyo Rio             Within the corporation F-term (reference) 4C083 AB172 AB222 AB282 AB292                       AB312 AB322 AB472 AC122                       AC132 AC472 AC622 AC692                       AC781 AC782 AC792 AC812                       AC862 AD041 AD042 AD092                       AD272 AD302 AD351 AD352                       BB48 BB55 CC41 EE06 EE07

Claims (3)

[Claims] 1. A total of 1.0 to 50% by mass of (A) a thickener, and an average molecular weight of 100 to 6 as the thickener.
1.0 to 5.0% by mass of polyethylene glycol, and (B) 0.4 to 0.004% of xanthan gum as a binder.
8 mass% and polyacrylic acid or its salt 0.4-1.
A toothpaste composition comprising 0% by mass and (C) 2.0-3.5% by mass of sodium lauryl sulfate as a surfactant. 2. One or two anti-inflammatory agents and / or bactericidal agents
The toothpaste composition according to claim 1, containing at least one species. 3. The toothpaste composition according to claim 2, wherein the anti-inflammatory agent is an antiplasmin agent.