WO2022255124A1

WO2022255124A1 - Liquid composition for oral use

Info

Publication number: WO2022255124A1
Application number: PCT/JP2022/020907
Authority: WO
Inventors: 博久田中; 妥治加藤; 純一天川
Original assignee: ライオン株式会社
Priority date: 2021-06-03
Filing date: 2022-05-20
Publication date: 2022-12-08

Abstract

Provided is a liquid composition for oral use that has appearance stability after storage at a high temperature or a low temperature; that is capable of imparting a unique and prominent refreshing sensation without any unpleasant taste; has excellent texture; and contains (A) potassium nitrate and (B) cetylpyridinium chloride, which have strong bactericidal effects.　This liquid composition for oral use contains (A) potassium nitrate, (B) cetylpyridinium chloride, (C) a nonionic surfactant, and (D) sucralose.

Description

Liquid oral composition

The present invention relates to a liquid oral composition containing potassium nitrate and cetylpyridinium chloride that has a stable appearance, gives a refreshing feeling in the oral cavity, and is excellent in use.

Potassium nitrate, which has an effect of suppressing hypersensitivity, is known as an active ingredient for preventing dentin hypersensitivity in oral compositions. Moreover, cetylpyridinium chloride is widely used as a disinfectant against halitosis-causing bacteria, particularly in liquid oral compositions. In order to combine the function of preventing hypersensitivity and the function of sterilizing bad breath-causing bacteria, it is effective to combine the two.
By the way, in liquid oral compositions such as mouthwashes, it is effective not only to have good taste but also to give a refreshing feeling in the oral cavity from the viewpoint of continuous use and improvement of effect. A clean feeling is required.

However, since potassium nitrate has a metallic taste and cetylpyridinium chloride has a bitter taste, when they are added to a liquid oral composition at the same time, they are perceived as unpleasant, and the feeling of use is significantly impaired. It was not possible to give a refreshing feeling.
On the other hand, potassium nitrate has low solubility and may form an insoluble complex with cetylpyridinium chloride. There was a problem of loss of sexuality.

Patent Document 1 (Japanese Patent Application Laid-Open No. 2016-150912) discloses that when a nonionic surfactant and an amphoteric surfactant are added to an ethanol-free liquid oral composition containing potassium nitrate and cetylpyridinium chloride, an insoluble precipitate is formed. It is proposed that the precipitation of substances is suppressed, the appearance stability is improved, and the feeling of use is that the bitterness is improved, but the refreshing feeling has not been studied and is unknown.
Patent Document 2 (Japanese Patent Application Laid-Open No. 2017-141178) describes that by blending α-olefin sulfonate and sucralose in a dentifrice composition containing potassium nitrate, foaming performance is improved, and the feeling of use is salty, bitter, and harsh. It is also proposed to improve it, but the feeling of refreshment is unknown. Patent Document 3 (Japanese Unexamined Patent Application Publication No. 2012-12303) discloses that when a specific amount of sucralose is added to cetylpyridinium chloride in an oral composition, the unpleasant taste (bitterness, harshness) of cetylpyridinium chloride is eliminated. However, the refreshing feeling was low.

JP 2016-150912 A JP 2017-141178 A Japanese Patent Application Laid-Open No. 2012-12303

It is an object of the present invention to provide a liquid oral composition containing potassium nitrate and cetylpyridinium chloride, which has a stable appearance, gives a refreshing feeling in the oral cavity, and is excellent in use. aim.

As a result of intensive studies to achieve the above object, the present inventors have found that (C) a nonionic surfactant is added to a liquid oral composition containing (A) potassium nitrate and (B) cetylpyridinium chloride. and (D) when sucralose is blended, the appearance stability is improved even after storage at high or low temperature, and furthermore, the oral cavity is provided with a unique and remarkable refreshing feeling without unpleasant feeling, and the feeling of use is excellent. In addition, they found that the bactericidal effect was high, and came to make the present invention.

More specifically, as described above, when the components (A) and (B) are used in combination in a liquid oral composition, the metallic taste derived from the component (A) and the bitter taste derived from the component (B) are unpleasant. In addition, a complex of the components (A) and (B) is formed to form an insoluble precipitate over time, resulting in a decrease in appearance stability. When the nonionic surfactant (C) was added to improve the properties, an off-taste due to the oiliness derived from the component (C) was developed, and the offensive taste was further enhanced. However, when the (A), (B) and (C) components are combined with the (D) component, the above-mentioned unpleasant taste is not felt, and the oral cavity is maintained while maintaining the appearance stability even after storage at high or low temperatures. It was possible to impart a unique and remarkable refreshing feeling without any sarcasm inside.
In this case, in the present invention, not only the sweetness of the component (D), but also the metallic taste derived from the component (A) and the bitter taste derived from the component (B) are masked by the component (D). Moderately suppressed, and furthermore, by masking the peculiar unpleasant taste caused by adding the (C) component to the combined system of the (A) and (B) components, a unique refreshing feeling without the above unpleasant taste. specific can be given.
Therefore, in the present invention, by making a liquid oral composition containing components (A), (B), (C) and (D), it has an effect of suppressing hypersensitivity and can be preserved even after storage at high or low temperatures. It has a stable appearance, can give a unique and remarkable refreshing feeling in the oral cavity without an unpleasant taste, is excellent in use feeling, and can also give a high bactericidal effect.
As shown in Comparative Examples below, when the components (A), (B) and (C) are contained and the component (D) is absent, even if the sweetener saccharin sodium or acesulfame potassium is added, it can be used. The feeling of refreshment after use is low and the lack of sarcasm is inferior (Comparative Examples 3 to 5). The feeling was low (Comparative Examples 1 and 2). On the other hand, as shown in the examples below, the liquid oral composition in which the components (A), (B), (C) and (D) of the present invention are combined has high temperature appearance stability. And it had excellent low temperature appearance stability, excellent refreshing feeling after use, almost no unpleasant taste after use, high bactericidal effect, hypersensitivity suppressing effect and bactericidal effect.
Patent Document 1 does not describe the blending of sucralose, and Patent Documents 2 and 3 do not describe a specific composition example in which cetylpyridinium chloride is blended with potassium nitrate. From Patent Documents 1 to 3, which do not focus on or mention a refreshing feeling, the combination of the components (A), (B), (C) and (D) of the present invention gives a unique refreshing feeling, It is unpredictable that securing the appearance stability and imparting a refreshing feeling are compatible.

Accordingly, the present invention provides the following liquid oral compositions.
[1]
(A) potassium nitrate,
(B) cetylpyridinium chloride;
A liquid oral composition containing (C) a nonionic surfactant and (D) sucralose.
[2]
The liquid composition for oral cavity according to [1], wherein {(A)+(B)}/(C) is 2.5 to 25 as a mass ratio.
[3]
The liquid composition for oral cavity according to [1] or [2], wherein {(A)+(B)}/(D) is 30 to 6,000 as a mass ratio.
[4]
2 to 8% by mass of component (A), 0.01 to 0.1% by mass of component (B), 0.3 to 0.9% by mass of component (C), and 0.001 to 0.001% of component (D) The liquid oral composition according to any one of [1] to [3] containing 0.1% by mass.
[5]
(C) The nonionic surfactant is one or more selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyethylene glycol fatty acid ester, glycerin fatty acid ester and polyoxyethylene polyoxypropylene glycol. The liquid oral composition according to any one of [1] to [4].
[6]
The liquid oral composition according to any one of [1] to [5], which is a mouthwash.

According to the present invention, it has a stable appearance even after storage at high or low temperatures, and can impart a unique and remarkable refreshing feeling that does not have an unpleasant taste in the oral cavity. A liquid oral composition containing components A) and (B) can be provided. The liquid composition for oral cavity of the present invention has an effect of suppressing hypersensitivity and a bactericidal effect due to the components (A) and (B), and is particularly effective for suppressing and preventing halitosis.

The present invention will be described in further detail below.
(A) Potassium nitrate is an active ingredient for preventing or suppressing dentine hypersensitivity, and has an effect of suppressing hypersensitivity.
Potassium nitrate can be used, for example, commercially available products such as Otsuka Chemical Co., Ltd.'s product name; Potassium Nitrate Super Tablets.

(A) The content of potassium nitrate is preferably 2 to 8% (% by mass, hereinafter the same), more preferably 3 to 7%, and even more preferably 4 to 6% of the total composition. When the amount is 2% or more, the effect of suppressing hypersensitivity is obtained, sufficient appearance stability is obtained, and a moderate metallic taste gives a unique refreshing feeling (hereinafter also abbreviated as "refreshing feeling") There is enough). When it is 8% or less, the appearance stability and refreshing feeling can be sufficiently secured, and it is possible to sufficiently prevent the metallic taste from being perceived as unpleasant.

(B) Cetylpyridinium chloride is a cationic bactericide and has a bactericidal effect against intraoral airborne bacteria.
As cetylpyridinium chloride, commercially available products such as cetylpyridinium chloride (trade name, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) can be used.

(B) The content of cetylpyridinium chloride is preferably 0.01 to 0.1%, more preferably 0.02 to 0.08%, and still more preferably 0.03 to 0.07% of the total composition. be. When the blending amount is 0.01% or more, sufficient bactericidal activity and appearance stability can be obtained, and moderate bitterness can sufficiently provide a refreshing feeling. When it is 0.1% or less, the appearance stability and refreshing feeling can be sufficiently ensured, and bitterness can be sufficiently prevented from being felt as a sarcasm.

(C) Nonionic surfactants are polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyethylene glycol fatty acid ester, glycerin fatty acid ester, in terms of imparting appearance stability and refreshing feeling, and further imparting bactericidal power. , polyoxyethylene polyoxypropylene glycol and the like are preferred. These may be used singly or in combination of two or more.
The polyoxyethylene hydrogenated castor oil preferably has an average added molar number of ethylene oxide (E.O. added molar number) of 40 to 100 mol, more preferably 60 to 100 mol.
Polyoxyethylene alkyl ethers are available from E.I. O. The number of added moles is 7 to 20 mol, especially 10 to 20 mol, and the number of carbon atoms in the alkyl group is 12 to 22, especially 12 to 18.
The polyethylene glycol fatty acid ester preferably has 16 to 20 carbon atoms, such as polyethylene glycol oleate.
The glycerol fatty acid ester preferably has 16 to 20 carbon atoms.
Polyoxyethylene polyoxypropylene glycol is available from E.I. O. It is preferable that the added mole number is 150 to 200 moles and the average added mole number of propylene oxide is 50 to 100 moles.
As component (C), the polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether (especially polyoxyethylene cetyl ether) may be used in combination.
Nonionic surfactants include, for example, polyoxyethylene hydrogenated castor oil, a trade name of Nikko Chemicals Co., Ltd.; Nikkor HCO; a trade name of Nihon Emulsion Co., Ltd.; is a product name of Aoki Oil Industry Co., Ltd.; Braunon CH-315L; polyethylene glycol oleate is a product name of Nippon Emulsion Co., Ltd.; Trade name: EMALEX GMS, and as polyoxyethylene polyoxypropylene glycol, commercially available products such as ADEKA's trade name: ADEKA (registered trademark) Pluronic can be used.

(C) The content of the nonionic surfactant is preferably 0.3 to 0.9%, more preferably 0.4 to 0.8% of the total composition. Appearance stability is fully obtained as a compounding quantity is 0.3% or more. When it is 0.9% or less, a refreshing feeling is sufficiently ensured, and the bactericidal power of the component (B) is sufficiently ensured.

(D) Sucralose refers to trichlorogalactosucrose, which is a sucrose derivative in which three hydroxyl groups of sucrose are substituted with chlorine. Sucralose is a sweetener having a sweetness similar to that of sugar. It has the effect of imparting a feeling.
As sucralose, commercially available products such as sucralose (trade name, manufactured by San-Eigen FFI Co., Ltd.) can be used.

(D) The content of sucralose is preferably 0.001 to 0.1%, more preferably 0.005 to 0.08%, and still more preferably 0.01 to 0.05% of the total composition. When the blending amount is 0.001% or more, a sufficiently refreshing feeling is obtained, and the unpleasant taste derived from the components (A) and (B) is also suppressed. When the content is 0.1% or less, the refreshing feeling is sufficiently maintained, and it is possible to sufficiently prevent the sweetness from being felt as an unpleasant taste.

In the present invention, this effect is more excellent when the amount ratio of each component is within the range shown below.
{(A) + (B)}/(C), which indicates the ratio of the total amount of components (A) and (B) to the amount of component (C), is 2.5 to 25 as a mass ratio. It is preferably 3 to 20, still more preferably 6 to 11. Within this range, the appearance stability is particularly excellent.

{(A)+(B)}/(D), which indicates the ratio of the total amount of components (A) and (B) to the amount of component (D), is 30 to 6,000 as a mass ratio. It is preferably 50 to 1,000, still more preferably 80 to 600. Within this range, the refreshing feeling is particularly excellent, and the unpleasant taste is further suppressed.
(A)/(D), which indicates the ratio of the amount of component (A) to the amount of component (D), is preferably 30 to 6,000, more preferably 50 to 2,000 as a mass ratio. More preferably 80-600. Within this range, the refreshing feeling is particularly excellent, and the unpleasant taste is further suppressed.
(B)/(D), which indicates the ratio of the amount of component (B) to the amount of component (D), is preferably 0.3 to 60, more preferably 0.5 to 16, as a mass ratio. It is more preferably 0.7-7. Within this range, the refreshing feeling is particularly excellent, and the unpleasant taste is further suppressed.
It is more preferable that all of the above-mentioned ratios are within the above-mentioned ranges from the viewpoint of appearance stability, refreshing feeling, and suppression of unpleasant taste.

(C)/(B), which indicates the ratio between the amount of component (B) and the amount of component (C), is preferably 4 to 80, more preferably 5 to 60, and still more preferably 6 as a mass ratio. ~50. Within this range, the bactericidal power of the component (B) is particularly enhanced.

The liquid oral composition of the present invention is prepared as a formulation in which ingredients are solubilized or emulsified, such as mouthwash, liquid dentifrice, mouth freshener, concentrated type mouthwash, and especially mouthwash. can be applied. In this case, in addition to the above components, appropriate known components can be blended according to the dosage form as needed. (D) a sweetener other than sucralose, a coloring agent, a flavoring agent, an active ingredient other than (A) potassium nitrate and (B) cetylpyridinium chloride, a pH adjuster, a solvent, and the like. In addition, the liquid composition for oral cavity of the present invention does not substantially contain an abrasive, and can be prepared as an abrasive-free formulation.
In the present invention, compared to paste-like preparations such as dentifrices, in liquid oral compositions such as mouthwashes, which tend to exhibit a relatively strong metallic taste, bitterness, etc. derived from the ingredients and be perceived as a disgusting taste. , It can give a remarkable refreshing feeling without sarcasm.
Hereinafter, the blending amount is the amount with respect to the entire composition.

Wetting agents include, for example, sugar alcohols such as sorbitol and xylitol, and polyhydric alcohols such as glycerin, ethylene glycol and polyethylene glycol. The content of the wetting agent is preferably 2 to 20%.

Thickeners include xanthan gum, carrageenan, hydroxyethylcellulose, sodium alginate, polyvinyl alcohol, carboxymethylcellulose, and the like. The blending amount of the thickener is usually 0 to 1%.

Anionic surfactants and amphoteric surfactants can be blended as optional surfactants, but they do not have to be blended. When any of these surfactants are blended, it is preferable that the total amount of the surfactants is 0.1 to 4%, particularly 0.1 to 2%, when combined with the blended amount of component (C).

Sweeteners include saccharin, saccharin sodium and the like.
As the colorant, highly safe water-soluble dyes such as Blue No. 1, Green No. 3, Yellow No. 4 and Red No. 105 can be added.

Natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracress oil, etc. , and l-menthol, l-carvone, cinnamic aldehyde, orange oil, anethole, 1,8-cineol, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spiranthol Perfume ingredients contained in the above natural essential oils such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenylglycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, maltol , ethyl maltol, gamma/delta decalactone, gamma/delta decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-l-menthyl carbonate and other fragrance ingredients, and furthermore, some Mixed flavors such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt, etc., which are obtained by combining flavoring ingredients and natural essential oils. These can be used individually by 1 type or 2 types or more. The blending amount of perfume is usually 0.00001 to 3%.

Optional active ingredients include nonionic bactericides such as isopropylmethylphenol, anti-inflammatory agents such as tranexamic acid and allantoin, enzymes such as dextranase, fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, water inorganic salts such as sodium chloride and aluminum lactate; vitamins such as ascorbic acid and tocopherol acetate; plant extracts; anticalculus agents and antiplaque agents. Any active ingredient can be added in an effective amount within a range that does not impair the effects of the present invention.

pH adjusters include phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid and carbonic acid and potassium, sodium and ammonium salts thereof, ribonucleic acid and salts thereof, sodium hydroxide and the like. A combination of citric acid, phosphoric acid and their sodium salts is particularly preferred.
The liquid oral composition of the present invention is adjusted to a pH of 4.0 to 9.0, particularly 5.0 to 8.0, especially 5.5 to 7.5 at 25°C. , and a combination of citric acid and sodium citrate, or a combination of sodium dihydrogen phosphate and sodium monohydrogen phosphate can be used as a pH adjuster in this vicinity.

Water (purified water) is generally used as the solvent.
The water content is preferably 60% or more, more preferably 60-95%, still more preferably 70-90%.
As a solvent, a lower monohydric alcohol having 2 or 3 carbon atoms such as ethanol, propylene glycol, or the like may be blended. The lower monohydric alcohol is suitable for imparting a refreshing feeling during use. It may be absent, and even if the amount is 0%, the refreshing feeling is excellent.

Examples, Comparative Examples, and Formulation Examples are shown below to specifically describe the present invention, but the present invention is not limited to the following Examples. In the following examples, % indicates % by mass unless otherwise specified.

[Examples, Comparative Examples]
Liquid oral compositions (mouthwashes) having compositions shown in Tables 1 to 4 were prepared by conventional methods and evaluated by the methods shown in (1) to (5) below. The results are also shown in the table.
The liquid compositions for oral cavity of Examples had an effect of suppressing hypersensitivity, and the appearance immediately after preparation was clear.

(1) Appearance Stability at High Temperature 70 mL of a sample (liquid oral composition) was filled in an 80 mL colorless and transparent PET container (manufactured by Yoshino Kogyosho Co., Ltd.) and stored in a constant temperature bath at 50° C. for 1 month. After that, the appearance stability was visually evaluated and evaluated according to the following evaluation criteria, and indicated by ⊚, ◯, Δ, and ×. Three samples were evaluated and the lowest evaluation was adopted.
Evaluation criteria ◎: There was no cloudiness at all ○: There was a slight cloudiness △: There was a little cloudiness ×: There was a lot of cloudiness

(2) Low temperature appearance stability Sample (liquid oral composition) was filled in 70 mL of a colorless and transparent PET container (manufactured by Yoshino Kogyosho Co., Ltd.) with a full amount of 80 mL and stored in a -5 ° C constant temperature bath for 1 month. After that, the appearance stability was visually evaluated and evaluated according to the following evaluation criteria, and indicated by ⊚, ◯, Δ, and ×. Three samples were evaluated and the lowest evaluation was adopted.
Evaluation Criteria ◎: There was no residue ○: There was a slight amount of residue △: There was some amount of residue ×: There was a lot of residue

(3) Refreshing feeling after use Five subject panelists put 20 mL of the sample (liquid oral composition) in their mouths, rinsed their mouths for 20 seconds, and then spit it out. Judged. Based on the average score of 5 people, evaluation was made according to the following evaluation criteria, and indicated by ⊚, ◯, Δ, and ×.
Here, the refreshing feeling is a sharp feeling that the inside of the oral cavity is clean and refreshing. This refreshing feeling is due to (C) no peculiar offensive taste derived from nonionic surfactants, (D) refreshing and refreshing sweetness of sucralose, (A) metallic taste of potassium nitrate, and (B) cetylpyridinium chloride. Combined with the bitterness, it has a unique refreshing feeling.
Rating criteria 4 points: considerably refreshing feeling 3 points: refreshing feeling 2 points: almost no refreshing feeling 1 point: no refreshing feeling Evaluation criteria ◎: average score of 3.5 points or more ○: Average score 2.5 points or more and less than 3.5 points △: Average score 1.5 points or more and less than 2.5 points ×: Average score less than 1.5 points

(4) Absence of disgust after use Five subject panelists took 20 mL of the sample (liquid oral composition) in their mouths, washed their mouths for 20 seconds, and then spit it out. The following rating criteria were used to judge the lack of disgust. Based on the average score of 5 people, evaluation was made according to the following evaluation criteria, and indicated by ⊚, ◯, Δ, and ×.
Scoring criteria 4 points: no disgust 3 points: almost no disgust 2 points: slightly disgusting 1 point: considerable disgust Evaluation criteria ◎: average score of 3.5 points or more ○: average score of 2. 5 points or more and less than 3.5 points △: Average score of 1.5 points or more and less than 2.5 points ×: Average score of less than 1.5 points

(5) Bactericidal effect The bacterial solution used was prepared by dissolving 30 g of THB (manufactured by BD Japan) as a culture solution in 1 L of purified water, and using Fusobacterium nucleatum ATCC 10953 strain as oral resident bacteria, anaerobic at 37 ° C. PBS was added to prepare a solution cultured for one day under the conditions (5% by volume carbon dioxide, 95% by volume nitrogen) so that the transmittance at 550 nm was 1.0. SCDLP medium (manufactured by BD Japan) was used as a medium for dilution. Add 0.1 mL of the bacterial solution to 4.0 mL of the sample (30-fold dilution of the liquid oral composition ^* ), stir, react at 37°C for 3 minutes, stir again, and add 4.0 mL of SCDLP medium in advance. Seven test tubes were prepared, and 0.44 mL of the sample containing the bacterial solution was added to the first test tube and stirred. 0.44 mL of this liquid was taken, added to a second test tube, and stirred. This operation was similarly performed on the 3rd to 7th test tubes in order. After stirring the culture solution in the 1st to 7th test tubes, 50 μL of the mixture was smeared on a THB agar plate containing 10% sterile defibrinated horse blood (manufactured by BD Japan) and cultured under anaerobic conditions.
The grown colonies were counted, the number of viable Fusobacterium nucleatum bacteria (cfu) remaining was determined, and the bactericidal effect on oral airborne bacteria was evaluated according to the following evaluation criteria.
*; Dilution rate assuming the dilution rate in the oral cavity after 3 hours using the mouthwash.
The number of viable bacteria in the control (using water instead of the sample) was 10 ⁸ .
Evaluation Criteria ◎: Viable count is less than 10 ⁴ ○: Viable count is 10 ⁴ or more and less than 10 ⁵ △: Viable count is 10 ⁵ or more and less than 10 ⁷ ×: Viable count is 10 ⁷ or more

Details of raw materials used are shown below.
(A) Potassium nitrate manufactured by Otsuka Chemical Co., Ltd. (B) Cetylpyridinium chloride manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. (C) Polyoxyethylene hydrogenated castor oil 100
Trade name; EMALEX HC-100, E.M. O. Addition mole number 100,
Nippon Emulsion Co., Ltd. (C) polyoxyethylene hydrogenated castor oil 60
Trade name; EMALEX HC-60, E.M. O. number of added moles 60,
(C) polyoxyethylene cetyl ether 15 manufactured by Nippon Emulsion Co., Ltd.
Trade name; Brownon CH-315L, E.P. O. number of added moles 15,
(C) polyethylene glycol oleate manufactured by Aoki Yushi Kogyo Co., Ltd.; trade name; EMALEX OE-10; (C) glycerin fatty acid ester manufactured by Nippon Emulsion Co., Ltd. trade name; Oxyethylene polyoxypropylene glycol Trade name; ADEKA (registered trademark) Pluronic, (D) sucralose manufactured by ADEKA, saccharin sodium manufactured by San-Ei Gen FFI Co., Ltd. (comparative product)
Acesulfame potassium manufactured by Aisan Chemical Industry Co., Ltd. (comparative product)
Manufactured by Neutrinova Japan

[Prescription Example 1] Mouthwash (A) Potassium nitrate 5.0
(B) cetylpyridinium chloride 0.03
(C) Polyoxyethylene hydrogenated castor oil 100 0.6
(D) Sucralose 0.02
Ethanol 10.0
Citric acid 0.01
Sodium citrate 0.3
Xylitol 3.0
Glycerin 5.0
Propylene glycol 5.0
Perfume 0.2
Purified water 70.84
Total 100%
pH; 6.2
Mass ratio of {(A) + (B)}/(C); 8.4
{(A) + (B)}/(D) mass ratio; 251.5
(A) / (D) mass ratio; 250.0
(B) / (D) mass ratio; 1.5
Mass ratio of (C)/(B); 20.0
Appearance stability at high temperature; ◎, Appearance stability at low temperature;
Refreshing feeling after use;

[Prescription Example 2] Mouthwash (A) Potassium nitrate 5.0
(B) cetylpyridinium chloride 0.05
(C) Polyoxyethylene hydrogenated castor oil 100 0.3
(D) Sucralose 0.02
Citric acid 0.01
Sodium citrate 0.3
Sorbit solution (70%) 10.0
Glycerin 5.0
Propylene glycol 5.0
Perfume 0.2
Purified water 74.12
Total 100%
pH; 6.2
Mass ratio of {(A) + (B)}/(C); 16.8
{(A) + (B)}/(D) mass ratio; 251.5
(A) / (D) mass ratio; 250.0
Mass ratio of (B)/(D); 2.5
Mass ratio of (C)/(B); 6.0
High temperature appearance stability; 〇, Low temperature appearance stability; 〇,
Refreshing feeling after use;

[Prescription Example 3] Mouthwash (A) Potassium nitrate 5.0
(B) cetylpyridinium chloride 0.05
(C) Polyoxyethylene hydrogenated castor oil 100 0.6
(D) Sucralose 0.005
Citric acid 0.01
Sodium citrate 0.3
Xylitol 1.0
Sorbit solution (70%) 5.0
Glycerin 5.0
Propylene glycol 5.0
Perfume 0.2
Purified water 77.835
Total 100%
pH; 6.2
Mass ratio of {(A) + (B)}/(C); 8.4
Mass ratio of {(A) + (B)}/(D); 1010.0
Mass ratio of (A) / (D); 1000.0
Mass ratio of (B)/(D); 10.0
Mass ratio of (C)/(B); 12.0
Appearance stability at high temperature; ◎, Appearance stability at low temperature;
Refreshing feeling after use;

[Prescription Example 4] Mouthwash (A) Potassium nitrate 5.0
(B) cetylpyridinium chloride 0.04
(C) Polyoxyethylene hydrogenated castor oil 100 0.6
(D) Sucralose 0.02
Sodium monohydrogen phosphate 0.05
Sodium dihydrogen phosphate 0.02
Xylitol 3.0
Glycerin 5.0
Propylene glycol 5.0
Perfume 0.2
Purified water 81.07
Total 100%
pH; 6.8
Mass ratio of {(A) + (B)}/(C); 8.4
Mass ratio of {(A) + (B)}/(D); 252.0
(A) / (D) mass ratio; 250.0
(B) / (D) mass ratio; 2.0
Mass ratio of (C)/(B); 15.0
Appearance stability at high temperature; ◎, Appearance stability at low temperature;
Refreshing feeling after use;

[Prescription Example 5] Mouthwash (A) Potassium nitrate 5.0
(B) cetylpyridinium chloride 0.05
(C) Polyoxyethylene hydrogenated castor oil 100 0.4
(D) Sucralose 0.01
Citric acid 0.01
Sodium citrate 0.3
Sorbit solution (70%) 7.0
Glycerin 3.0
Propylene glycol 10.0
Perfume 0.2
Purified water 74.03
Total 100%
pH; 6.2
Mass ratio of {(A) + (B)}/(C); 12.6
Mass ratio of {(A) + (B)}/(D); 505.0
(A) / (D) mass ratio; 500.0
Mass ratio of (B)/(D); 5.0
Mass ratio of (C)/(B); 8.0
Appearance stability at high temperature; ◎, Appearance stability at low temperature;
Refreshing feeling after use;

Claims

(A) potassium nitrate,
(B) cetylpyridinium chloride;
A liquid oral composition containing (C) a nonionic surfactant and (D) sucralose.
The liquid oral composition according to claim 1, wherein {(A) + (B)}/(C) is 2.5 to 25 as a mass ratio.
The liquid oral composition according to claim 1 or 2, wherein {(A) + (B)}/(D) is 30 to 6,000 as a mass ratio.
2 to 8% by mass of component (A), 0.01 to 0.1% by mass of component (B), 0.3 to 0.9% by mass of component (C), and 0.001 to 0.001% of component (D) The liquid oral composition according to any one of claims 1 to 3, containing 0.1% by mass.
(C) The nonionic surfactant is one or more selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyethylene glycol fatty acid ester, glycerin fatty acid ester and polyoxyethylene polyoxypropylene glycol. The liquid oral composition according to any one of claims 1-4.
The liquid oral composition according to any one of claims 1 to 5, which is a mouthwash.