JP2001172145A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for the oral cavity excellent in prophylactic effects on dental caries and excellent even in feeling of use. SOLUTION: This composition for the oral cavity is characterized as formulating (A) disintegrable cellulose granules comprising one or more kinds of sugar alcohols as a binder with (B) a noncationic bactericide.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a causative bacterium,
The present invention relates to an oral composition having a high effect of suppressing S. mutans in the oral cavity and an excellent effect of preventing dental caries.

[0002]

2. Description of the Related Art Conventionally, dentifrices containing cellulose include those containing cellulose as a substitute for abrasives (Japanese Patent Application Laid-Open No. 55-98111), as well as improvements in shape retention and mouth feel. For this purpose, those containing cellulose (JP-A-5-58861) have been proposed. On the other hand, proposals have been made on oral compositions having various functions given by blending granules and capsules with the oral compositions. A composition containing a pigment for the purpose of an indicator after completion of tooth brushing (Japanese Patent Application Laid-Open No. 60-16913), a granular taste component coated with a coating substance and a granular tooth brush base are mixed to change the taste during tooth brushing. The intended product (JP-A-62-116505), the one obtained by mixing a medicinal ingredient with granules (JP-A-48-19738, 49-13224)
No. 9, 55-153709, JP-A-3-271215
No. 1), and for the purpose of removing plaque (Japanese Unexamined Patent Publication No.
No. 299211, and No. 4-243816).

Further, a composition exhibiting an effective plaque removal effect containing cellulose granules (Japanese Patent Application Laid-Open No. 9-40537).
Although it has been proposed, the granulated cellulose particles in this case are not disintegrating, but are expected to have an abrasive power, and when used in an oral composition, always remain in the oral cavity and cause discomfort. There was a problem of remaining. Also, various oral compositions having an effect of suppressing cariogenic bacteria have been proposed, but the caries-preventing effects of conventional oral compositions have not yet been satisfactory and enhanced caries. There is a need for the development of oral compositions having a prophylactic effect.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide a composition for oral cavity which is excellent in the effect of preventing dental caries and which has an excellent feeling upon use.

[0005]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have found that water-insoluble cellulose powder can be used as a binder for one or more sugar alcohols. An oral composition comprising a combination of disintegrating cellulose granules granulated using the combination and one or more non-cationic germicides is surprisingly found to be the number of caries-causing bacteria in the oral cavity. Found to significantly reduce
The present invention has been completed. That is, according to the present invention,
An oral composition comprising a disintegrable cellulose granule (A) containing one or more sugar alcohols as a binder and a non-cationic bactericide (B) is provided.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The oral composition of the present invention (hereinafter, also simply referred to as composition) contains disintegrable cellulose granules containing a sugar alcohol as a binder. In this case, various conventionally known sugar alcohols can be used as the binder, and specific examples thereof include sorbitol (sorbitol), xylitol (xylitol), maltitol (maltitol), arabit, mannitol , Galactit, palatinit, erythrière and the like. In the present invention, use of sorbitol and xylit is particularly preferable. This sugar alcohol can be easily obtained by reducing the aldehyde group or ketone group of the sugar and converting it to an alcohol group.

As the cellulose powder, conventionally known water-insoluble cellulose powder having an average particle size of 1 to 50 μm is used.
Preferably it is 10 to 40 μm. Examples of the cellulose powder particularly preferably used in the present invention include, in addition to α-cellulose and microcrystalline cellulose, pulp powder, insoluble powdered cellulose, pulp and cellulose which are insolubilized and pulverized by chemical treatment.

The disintegrable cellulose granules used in the present invention are:
One or two binders for cellulose powder
It can be obtained by mixing at least one kind of sugar alcohol, and granulating the mixture by a conventional method in the presence of moisture, if necessary. As a granulation method, a compression granulation method, an extrusion granulation method, or the like can be used. The usage ratio of the sugar alcohol is 1 to 50% (mass percentage, the same applies hereinafter), preferably 10 to 40% in the granules. If it is more than this, the disintegration strength of the obtained granules will be weak, while if it is less than that, the disintegration strength of the obtained granules will be too high, so-called non-disintegrable crystalline cellulose. Such non-disintegratable crystalline cellulose remains in the mouth without disintegration, causing discomfort. In the disintegrable cellulose granules used in the present invention, the average particle size is 50 to
It is in the range of 1000 μm, preferably 100-300 μm. If it is smaller than this, the plaque cleaning effect or the like will be insufficient, while if it is larger than that, a foreign-body sensation will be generated in the oral cavity. The shape of the granules is not particularly limited, and may be granular or spherical, pellets, or the like. In the present invention, since a sugar alcohol was used as a binder for the disintegrable cellulose granules,
It has a high affinity with other active ingredients, and can provide advantages such as giving a cool feeling in the oral cavity.

[0009] The compositions of the present invention contain one or more nonionic fungicides. As such a non-cationic bactericide, various kinds of conventionally known bactericides are used. Examples of such a bactericide include halogenated diphenyl ether bactericides, phenolic compound bactericides, and the like. Specific examples thereof include triclosan, isopropylphenol, p-hydroxybenzoic acid, trichlorocarbanide and the like.

In the composition of the present invention, the compounding amount of the disintegrable cellulose granules is 0.01 to 50 in the total composition.
%, Preferably 0.1 to 10%. The amount of the non-cationic bactericide is 0.001% to 1%, preferably 0.0%.
1 to 0.5%. If the amount is less than the above range, the bactericidal effect may not be sufficiently exhibited, while if the amount is more than the above range, the taste of the composition may be deteriorated.

[0011] In addition to the above components, the composition of the present invention is blended with appropriate conventional components depending on the specific product of the composition. For example, in the case of dentifrices such as toothpastes, abrasives, thickeners, binders, sweeteners, flavors, coloring agents, preservatives, active ingredients and the like are blended. These components are blended in an amount in the range generally applied conventionally. As the abrasive, silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, titanium silicate, dibasic calcium phosphate, dibasic calcium phosphate anhydrate, calcium pyrophosphate, aluminum hydroxide, alumina, magnesium carbonate, Tertiary magnesium phosphate,
Zeolite, zirconium silicate, tricalcium phosphate, hydroxyapatite, fluoroapatite, calcium deficient apatite, quaternary calcium phosphate, eighth
Examples thereof include calcium phosphate and a synthetic resin-based abrasive. The amount of these components is preferably 2 to 60%, particularly preferably 8 to 45% of the whole composition.

Examples of the humectant include sorbitol, penchit, erythritol, glycerin, propylene glycol and polyethylene glycol (for example, having a molecular weight of 400 to 6).
00), ethylene glycol, reduced starch and the like. The compounding amount is about 5 to 80% in the oral composition, but xylitol can be used as part or all of the wetting agent.

As the binder, carboxymethylcellulose, hydroxyethylcellulose, xanthan gum,
Carrageenan, carbopol, guar gum, montmorillonite, gelatin and the like.

As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant and the like are used. Specific examples thereof include sodium lauryl sulfate, sodium α-olefin sulfonate, N-acyl glutamate,
-Alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, pluronic and the like. As the sweetener, saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartin and the like are used. As preservatives, paraoxybenzoate, sodium benzoate and the like are used.

Various active ingredients include fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate and the like, and aqueous solutions such as potassium salt and sodium salt of orthophosphoric acid. Phosphoric acid compound, allantoinchlorohydroxyaluminum,
Hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and salts thereof, sodium chloride, tranexamic acid, epsilon aminocaproic acid, dl-tocopherol acetate, α-bisabolol, isopropylmethylphenol, chlorhexidine salts, cetylpyridinium chloride, azulene, glycyrrhetinic acid, copper Chlorophyllin sodium, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and derivatives thereof, sodium tripolyphosphate, zeolite, amylase, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone,
Extracts such as epidihydrocholesterine, benzethonium chloride, dihydrocholesterol, trichlorocarbanide, zinc citrate, a soft cane extract, oak extract, clove, rosemary, ogre, safflower and the like are used.

Examples of the flavor include terpenes such as L-menthol, carvone, anethole, limonene, and derivatives thereof, L-menthyl acetate, strawberry flavor, sage oil, rosemary oil, salicyl san methyl, ginger extract, eugenol, Spirantol, peppermint oil, orange oil, anise oil, lemon oil, melon flavor, pineapple flavor and the like are used.
Examples of the colorant include Blue No. 1, Yellow No. 4, Green No. 3, and titanium dioxide. In addition, the compounding amount of these components can be a usual amount within a range not to impair the effects of the present invention.

The oral composition of the present invention includes various products applied to the oral cavity. Such products include:
Toothpaste, liquid toothpaste, mouthwash, mouth freshener and the like. The oral composition of the present invention can be prepared by mixing the above-mentioned disintegratable cellulose granules and a non-cationic bactericide with a conventional oral composition such as a dentifrice or mouthwash. In addition, the oral composition of the present invention can be obtained by using the composition as a base material composition and blending a conventional component corresponding to the specific product composition into the composition.

[0018]

EXAMPLES Hereinafter, the present invention will be described specifically with reference to Examples, but the present invention is not limited to the following Examples.

Example 1, Comparative Examples 1 to 4 A dentifrice composition having the component composition (%) shown in Table 1 was prepared, and its bactericidal effect against cariogenic bacteria was evaluated as follows. Table 2 shows the results.

(Bactericidal activity against cariogenic bacteria) Fifteen healthy adults were divided into three groups, and the three types of toothpaste shown in the table were used for 3 months each. The number of S. mutans bacteria in saliva before and after use Was measured by the following method. Table 2 shows the results. (Bacterial count method) Unstimulated whole saliva was collected before and after the experiment.
Among them, 1 ml of whole saliva is uniformly dispersed by ultrasonic for 5 seconds.
Serial 10-fold dilution was performed with a 0.05 M phosphate buffer (pH 7.1) containing 0.4% potassium chloride. This dilution was applied to a Mitis salivalius medium containing 20% sucrose and 0.2 U / L bacitracin. The plate was anaerobically cultured at 37 ° C. for 48 hours in 95% N ₂ and 5% CO ₂ to identify S. mutans bacteria morphologically and to measure the number of bacteria.

[0021]

[Table 1]

[0022]

[Table 2] (3) SDS indicates sodium lauryl sulfate. Also, C in Table 2
FU indicates the viable cell count.

From the results shown in Table 2, the composition of the present invention shows that
S. in saliva It turns out that it shows an excellent effect in suppressing mutans bacteria.

The specific contents of the collapsible particles and the like shown in Table 1 are as follows. (1) Disintegrable particles A Cellulose granules obtained by molding a mixture comprising 80% of crystalline cellulose nucleus having an average particle diameter of 40 μm and 20% of xylitol into a spherical shape (average particle diameter: 200 μm) (2) Crystalline cellulose particles average particle diameter Crystalline cellulose particles obtained by molding a fine cellulose powder of 15 μm into a spherical shape without adding sugar alcohol (average particle size: 200 μm)

Examples 2 to 13 Dentifrice compositions having the component compositions (%) shown in Tables 3 and 4 were prepared. Each of these compositions shows a good inhibitory effect on cariogenic bacteria and also has an excellent feel upon use.

[0026]

[Table 3]

[0027]

[Table 4]

The specific contents of the components such as the disintegrating particles A shown in Tables 3 and 4 are as follows. (1) Disintegrable particles A Cellulose granules obtained by molding a mixture of 80% of crystalline cellulose nucleus (average particle size of 40 μm) and 20% of xylitol into a spherical shape (average particle size: 200 μm) (2) Disintegrable particles B Disintegrable particles A, using sorbitol 20% instead of xylitol 20% (average particle size: 100 μm)
m) (3) Disintegrable particles C In disintegrable particles A, instead of 20% sorbitol,
Using 10% sorbitol and 20% maltitol (average particle size: 250 μm) (4) Disintegrable particles D In disintegrable particles A, instead of 20% sorbitol,
One using erythritol 30% (average particle size: 300
μm) (5) CMC carboxymethylcellulose (6) PEG 400 polyethylene glycol with a molecular weight of 400 (7) MFP sodium monofluorophosphate (8) SDS sodium lauryl sulfate

[0029]

Industrial Applicability The oral composition of the present invention is excellent in suppressing the growth of bacteria that cause a touch and, despite containing cellulose granules, disintegrates in the oral cavity. , And does not cause discomfort or discomfort.

Continuation of the front page (72) Inventor Noriyuki Monoi 1-3-7 Honjo, Sumida-ku, Tokyo F-Term in Lion Corporation (reference) 4C083 AB172 AB222 AB242 AB282 AB292 AB322 AB332 AC122 AC131 AC132 AC472 AC662 AC792 AC812 AC862 AC902 AD042 AD261 AD262 AD272 AD302 AD352 AD642 BB48 CC41 DD22 EE32

Claims (1)

[Claims] 1. An oral composition comprising a disintegrable cellulose granule (A) containing one or more sugar alcohols as a binder and a non-cationic bactericide (B).