JP2002205930A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To improve the disagreeable taste of a mastic-containing composition for oral cavity application caused by the characteristic cypress-like taste of mastic. SOLUTION: The characteristic taste of a mastic-containing composition for oral cavity application is remarkably improved by formulating l-menthol and/or carvone to the composition.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to an oral composition containing mastic.

[0002]

2. Description of the Related Art Pistaci, a perennial evergreen tree of the family Urushi, distributed from the Mediterranean coast to the Canary region of Morocco and cultivated actively in Alseria.
a Lentiscus L. ) Or secretions obtained from the stems and branches of their varieties are called mastics. This sap is a viscous natural gum that hardens over time. Since mastic has a bactericidal and antibacterial effect such as anti-H. Pylori, it has been blended in gum and the like since ancient times. Mastic is other food,
It is used for various products such as toothpaste and perfume.

[0003]

However, when mastic is incorporated into an oral composition such as toothpaste, the mastic itself has a unique cypress-like taste, and improvement of the taste is a problem. ing.

[0004]

Means for Solving the Problems The present inventors have conducted various studies to improve the unique cypress-like taste of a mastic-containing oral composition. As a result, the composition containing l-menthol and / or carvone was added. By doing so, it has been found that the peculiar taste of the mastic-mixed oral composition is remarkably improved, the taste is refreshed, and the usability can be improved, and the present invention has been completed. That is, the present invention relates to an oral composition comprising a mastic and containing l-menthol and / or carvone.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The oral composition of the present invention is blended with the following components in accordance with a usual production method, and powdered dentifrice, moisturizing dentifrice, toothpaste, liquid dentifrice, liquid dentifrice, mouthwash And various formulations such as mouth fresheners. It contains mastic as an active ingredient and is used in combination with l-menthol and / or carvone.

[0006] In the present invention, as a mastic,
Mastice tree (Pistasia Lenti), an evergreen tree of the family Urushi, distributed from the Mediterranean coast to the Moroccan and Canary regions, and is actively cultivated in Alseria.
scus L. ) Or a collection of secretions obtained from trunks and branches of those varieties thereof. The amount of the mastic is not particularly limited, but is usually 0.001 to 10% (mass%, the same applies hereinafter) of the whole, especially 0.0
1-5% is preferred.

[0007] l-Menthol and carvone may be isolated or synthesized from essential oils, or an essential oil containing l-menthol or carvone, for example, mint oil may be used as it is. As mint oil, Japanese mint oil (Japanes Mint Oil), peppermint oil (Peppermint O)
il), Mitcham Peppermint Oil,
English Black Mint Oil and English White Mint Oi
l), spearmint oil (Spearmint Oil, native type and Scotch type) and the like. The above mint oil is 1
The species may be used alone or in combination of two or more, and may be used in combination with isolated or synthetic l-menthol or carvone. The blending amount of l-menthol and carvone is 0.01 to 5% of the whole, more preferably 0.0 to 5%.
5 to 3%. If the amount is less than 0.01%, the characteristic taste may not be sufficiently improved, resulting in a lack of refreshing feeling. If the amount is more than 5%, the pungency may be too strong.

The oral composition of the present invention may contain other active ingredients besides mastic.
For example, dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, superoxide dismutase, gillicellophosphate, water-soluble inorganic phosphate compound, sodium monofluorophosphate, sodium fluoride, fluorides such as tin fluoride, Allantoin, aluminum allantoin, aluminum chlorohydroxy allantoin, tocopherol acetate, isopropylphenol, chlorophyll, sodium copper chlorophyll, flavonoids, β-glycyrrhetinic acid, glycyrrhizinates, hinokitiol, dihydrocholesterol, epsilon aminocaproic acid, tranexamic acid, triclosan, chlorhexidine salts, Cetylpyridinium chloride, bisabolol, benzethonium chloride, zinc citrate, zinc chloride, Copper conoate, copper chloride, ethane hydroxyphosphonate, vitamins A, C, E, B6, vitamins such as pantothenate, amino acids such as glycine, lysine, histidine, sodium chloride, sodium bicarbonate, aluminum lactate, potassium nitrate, One or more of sarcosinate, tannin-like substances, etc. can be blended. In addition, the above-mentioned active ingredient can be blended in a blending amount within a range that does not hinder the effects of the present invention.

[0009] Extracts obtained from water, alcohol or organic solvent extracts of crude drugs, such as nutmeg (meat meg), areca (beetle), licorice (licorice), yakumoso (masu-miso), sicon (purple dark blue), orchid etc. Is known to have antibacterial activity against oral bacteria (Japanese Patent Application Laid-Open No. 6-157259), and such a crude drug extract can be blended with the oral composition of the present invention. .

Further, in the composition of the present invention, in addition to 1-menthol and carvone, anethole, methyl salicylate,
Limonene, orange oil, lemon oil, eucalyptus oil, acacia oil, fennel oil, kuenthu oil, column oil, camphor oil, nitrogen oil, cinnamon oil, silica leaf oil, rose oil,
Other flavor components and essential oils such as sandalwood oil, clove oil, herb oil, banana oil, apple oil, and compounded flavors may be blended within a range that does not affect the effects of the present invention.

[0011] The oral composition of the present invention can be prepared by a usual method by appropriately blending components according to the dosage form as other optional components in addition to the above essential components. For example, in the case of dentifrices, an abrasive, a wetting agent, a thickener, a surfactant, a sweetener, a coloring agent, a preservative, a pH adjuster, and the like are added in addition to the above essential components. As an abrasive, for example, aluminum hydroxide, aluminium oxide, aluminum silicate,
Zirconium silicate, silicic anhydride, silica gel, precipitated silica, calcium carbonate, calcium phosphate, calcium pyrophosphate, calcium hydrogen phosphate, hydroxyapatite, fluoroapatite, halogenated apatite, magnesium carbonate, magnesium phosphate, insoluble sodium metaphosphate, insoluble One or more of calcium metaphosphate, titanium oxide, zeolite, synthetic resin-based abrasives and the like may be blended.

Further, glycerin, sorbitol, ethylene glycol, propylene glycol,
1, such as 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, dipropylene glycol, maltitol, xylitol, lactitol, etc.
Species or two or more species may be blended. Also, as a thickener, hydroxyethyl cellulose, sodium carboxymethyl cellulose, methyl cellulose, carrageenan, carboxyvinyl polymer, sodium polyacrylate, sodium alginate, xanthan gum, duran gum,
One or more of tragacanth gum, karaya gum, gum arabic, polyvinyl alcohol, polyvinyl pyrrolidone, silica gel, aluminum silica gel, veegum, laponite and the like may be blended.

Further, anionic surfactants such as alkyl sulfate, alkyl benzene sulfonate, sodium lauryl sulfate, sodium lauroyl sarcosine, sodium α-olefin sulfonate, N-acyl glutamate and the like, 2-alkyl-N-carboxy-N -Amphoteric surfactants such as hydroxyethyl imidazolinium betaine, sucrose fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester,
Nonionic surfactants such as N-acyl taurine salt, alkylol amide, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester, pluronic, polyoxyethylene sorbitan monostearate, sorbitan monooleate, monostearic ester, pluronic 1 or 2 such as a cleaning component such as a cationic surfactant, etc.
More than one surfactant may be included.

Further, organic acids such as citric acid, malic acid and acetic acid and salts thereof, inorganic acids such as phosphoric acid, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, ammonium carbonate, ammonium hydrogen carbonate, Inorganic calcium salts such as sodium potassium carbonate, lithium carbonate, calcium chloride, calcium nitrate, calcium sulfate, calcium glycerophosphate, calcium hydroxide, calcium lactate, calcium acetate, calcium malonate, calcium citrate, calcium glyconate, calcium glycerate PH adjusters such as organic acid calcium such as calcium tartrate, calcium phytate, saccharin, sodium saccharin, xylitol, stevioside, stevia extract, rebaudioside, paramethoxy Sweeteners such as annamic aldehyde, neohesperidyl dihydroxy chalcone, perillartin, thaumatin, glycyrrhizin, glycyrrhizin monoglucoside, hernanzurtin, trehalose, etc .; legal pigments such as blue No. 1 and yellow No. 4; Agents, sodium benzoate, paraoxybenzoates, preservatives such as alkyldiaminoethyl gliacin hydrochloride, and other components can be added. It can be produced by kneading with water.

Further, other oral compositions can be produced by using components according to the type.

The composition for oral cavity of the present invention has an antibacterial activity against the causative bacteria of periodontal disease, has an improved taste peculiar to mastic, has a refreshing taste, and has an excellent feeling in use. It is useful for prevention of periodontal disease.

[0017]

EXAMPLES Hereinafter, the oral composition of the present invention will be specifically described based on examples, but the present invention is not limited to these examples. The perfume components shown in Table 1 were blended as shown below, and a mouthwash was prepared according to a usual production method. Using this mouthwash, a special panel (10
) Was evaluated by a sensory test. Table 1 shows the results.

The prescription amount Purified water balance unit 100 shown in perfume ingredients Table 1. As shown in concentrated glycerol 5 wt% ethanol 3 polyoxyethylene sorbitan arsenide Bu monostearate 3 mastic 1 Table 1 Note that sensory evaluation was performed according to the following criteria.

Evaluation of the smell and taste of mastic ○: 2 or less answered that they had smell and taste Δ: 3 to 7 people answered that they smelled and tasted X: answered that they smelled and tasted 8 to 10 people

Evaluation of refreshing feeling ：: 8 to 10 people answered that there was a refreshing feeling Δ: 3 to 7 people answered that there was a refreshing feeling ×: Not more than 2 people answered that there was a refreshing feeling

[0021]

[Table 1]

In addition, a mouthwash having the following formulation was prepared according to a usual production method (Reference Example 1). The feeling of use of the mouthwash was evaluated by a sensory test by a specialized panel.

Formulation (Reference Example 1) Concentrated glycerin 5% by mass Ethanol 3 Polyoxyethylene sorbitan monostearate 3 Purified water Balance 100 The smell and taste unique to Reference Example 1 containing no mastic were found.

As shown in Comparative Example 5 in Table 1, the oral composition containing mastic has a unique taste and lacks a refreshing feeling, but as shown in Examples 1 to 8, By blending l-menthol and carvone with the stick-containing oral composition, the taste peculiar to mastic disappeared, the taste became refreshing, and the usability was improved.

Formulation Example 1 Toothpaste 40% by mass of calcium phosphate Concentrated glycerin 35 Sodium carboxymethylcellulose 1.5 Sodium lauryl sulfate 1 Mastics 0.25 l-menthol 0.5 Purified water Residue 100

Formulation Example 2 Liquid Dentifrice Concentrated Glycerin 30% by Mass Sodium Lauryl Sulfate 1 Ethanol 3 Sodium Polyacrylate 0.5 Xanthan Gum 0.1 Mastic 0.3 Polyoxyethylene Sorpetan Monostearate 8 Carboxyl 0.3 Peppermint Oil 0.5 purified water 100 remaining

[Formulation Example 3] Dental dentifrice Calcium phosphate 45% by mass Calcium carbonate 40 Mastic 0.25 Carvone 0.5 Saccharin sodium 0.1 l-Menthol 0.5 Purified water Balance 100

Formulation Example 4 Mouthwash Concentrated Glycerin 15% by mass Ethanol 8 Polyoxyethylene sorbitan monostearate 2 Mastic 0.05 Mint oil 0.3 Orange oil 0.05 Carvone 0.2 Purified water Residue 100

[Formulation Example 5] Liquid mouth freshener ethanol 40 mass% concentrated glycerin 15 mastic 0.25 peppermint oil 0.5 polyoxyethylene hydrogenated castor oil 5 spearmint oil 0.1 purified water balance 100

[0030]

According to the present invention, the taste of a mastic-containing oral composition can be remarkably improved by adding l-menthol and / or carvone, giving a refreshing feeling and an excellent feeling in use. A formulated oral composition is obtained.

 ────────────────────────────────────────────────── ─── Continued on the front page (72) Inventor Kazuaki Tanaka 12-13, Kaminano, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture F-term in FANCL Central Research Laboratories 4C083 AA111 AA112 AB052 AB292 AB312 AC102 AC122 AC432 AC442 AC782 AC862 AD092 AD272 AD352 AD531 AD532 CC41 DD22 DD27 EE06 EE32 EE33 EE34

Claims (1)

[Claims] An oral composition comprising a mastic containing l-menthol and / or carvone.