JP2600692B2 - Deodorants - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a deodorant which has excellent deodorizing power and can be widely used for malodor generated in a human body, a house, an environment and the like.

2. Description of the Related Art Conventionally, as a deodorant for removing bad breath and against malodors generated in general homes and factories, a deodorant containing a plant extract having deodorizing power as an effective deodorant (Japanese Patent Application Laid-Open No. 57
-204278, 61-240960, and Japanese Patent Application No. 61-169567), and deodorants using chemicals such as sodium perborate and hydrogen peroxide, and enzymes such as proteolytic enzymes such as papain. Deodorants (JP-A-52-38026, JP-A-52-38026)
Nos. 27 and 60-58150), and deodorants focusing on the deodorizing power of quinone (Japanese Patent Publication Nos. 51-33974 and 53-45372) have been proposed.

Problems to be Solved by the Invention However, these deodorants have poor deodorizing power and are insufficient in effect, and when a large amount of the deodorant active ingredient is blended in a large amount, problems such as coloring, deterioration of taste, sedimentation and the like are caused. May occur. Some deodorants using chemicals or enzymes have a relatively strong deodorizing effect. In any case, it is desired to further enhance the deodorizing power.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a deodorant having a high deodorizing power and a wide application range.

Means and Action for Solving the Problems The present inventors have conducted intensive studies to achieve the above object, and as a result, from a solvent extract of a plant selected from red algae plants, brown algae plants, gymnosperms and angiosperms. It has been found that by using an effective deodorant component and an oxidizing agent or a reducing agent together, the two act synergistically to obtain a deodorant having a very high deodorizing effect.

 Hereinafter, the present invention will be described in more detail.

The deodorant of the present invention is a combination of a deodorant active ingredient and an oxidizing agent or a reducing agent.
Oral products such as dentifrice, mouthwash, mouth spray, troche, gum to prevent and remove tobacco odor, food and beverage,
Soaps, sprays, shampoos, rinses, creams, lotions, etc. for the prevention and removal of human body odors and physiological odors, cosmetics for the hair, foot sprays, undershoes of shoes, and tobacco odors of cabbage in homes Deodorant for garbage, filter for indoor cleaning, deodorant for toilet sewage and feces, neutralizer, deodorant for garbage odor and putrefaction odor, preventing and eliminating pet animal odor Soap, body shampoo, deodorant for car exhaust gas and vehicle odor, deodorant used for sewage treatment plant and processing plant, pulp factory, low odor feed, etc.
It is widely used as a deodorizer for odors generated in the human body, house, environment, etc.

The deodorant active ingredient of the present invention includes red algae plants, brown algae plants,
A gymnosperm or angiosperm which has a deodorizing effect and uses a solvent extract. Specifically, as the above-mentioned plants, specifically, the red algal plant phylums of the genus Echinacea, the family of the genus Echinacea, the family of the cynocephalus, the species of the cynosum, the the family of the genus Echinacea, the genus Azotaceae, , Kurosozo,
Kobusoso, Papyrazoso, Brown Algae Phytophyta Mozuku, Albaceae Alame, Kurome,
Hijiki, Honwara, Akamoku, Sawtooth mock, Umitrano, Obanokosirimoku, Nejimoku, Narasamo, Mamedawara, Yasumatamoku
Jolemoku, Isomoku, Togemoku, Pea moku, Futamoemoku, Wakame of the order Apocynidae, Ginkgo biloba of the Gymnosperm, Metasequoia of the cedar family Cedar, Pepper of the angiosperm, Pepper, Hihatsu, Kubeba Birch, Birch, Berberidaceae, Berberidaceae, Rhododendron, Rhododendron, Rhododendron, Ranunculaceae, Magnolia L. Barnaceae Nanten, Epimedium, Camphor tree Sassafras, Camphor tree, Papaveraceae poppy and Brassicae var., Brassicaceae moss moss, Rosaceae mansaceae hammelis, Rosaceae yamazakura, Heavy strawberry,
Hawthorn, leguminous rattania, suicide, oak, fusarium occidental family salamander, yellowfin, henruta, nemoptera sendan, sidemembroidal camellia tea, camellia, tenninnaceae pomegranate, pomegranate family Clove, eucalyptus, allspice, umbrella-shaped flower of celery, anise, casa mochi, azalea, azalea,
Rotifer, sage of Lentinaceae, sage of Lamiaceae, tubular thyme, thyme, marjoram, rosemary, koganebana, naginata kouju, melissa, mint, black mint, perilla, basil, oregano, savory,
Examples include the solanaceae wolfberry, the scrophulariaceae spruce, the Rubiaceae Rapaceae assemblage, the Coleoptera asteraceae strawberry, tarragon, arnica, and the ginger ginger family Kajutsu and Sanna.

When obtaining a solvent extract from these plants, the whole plant may be used as the plant, or leaves, bark, flowers, pericarp, fruits, rhizomes, roots and other parts of the plant may be used. Depending on the plant, a site containing a relatively large amount of the deodorant active ingredient of the plant can be selected and used.

When an effective deodorant ingredient is obtained from these plants, a known method can be adopted. For example, after drying a plant, it is cut and powdered to obtain water, ethyl ether, ethylene chloride, dioxane, acetone, ethanol, One or more polar solvents such as n-butanol, ethyl acetate, propylene glycol, or n-hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene, benzene For example, a method of extracting with one or more nonpolar solvents such as the above or a mixed solvent of these polar and nonpolar solvents can be employed. In this case, a normal method can be adopted as the extraction operation, for example, a method of digesting the plant in a solvent can be adopted.

In addition, the extract obtained by the above-mentioned extraction operation is usually mixed with a deodorant after removing the solvent, but in some cases, particularly when the solvent is water or ethanol, the solvent is distilled off. It can be blended with the deodorant as it is without leaving it.

In addition, as the plant extract, one of the above extracts may be used alone or as a mixture of two or more (a mixture of bromides or one obtained by simultaneously extracting two or more plants). .

Further, the type of the oxidizing agent or the reducing agent used in the present invention is not particularly limited as long as it is other than oxidoreductase, and may be an inorganic compound or an organic compound. For example, one or more of the following compounds may be used. can do.

Inorganic Compound (1) permanganate acids HMnO _4, MeMnO _4, etc. (2) chromic acid and related compounds _{CrO 3, Me 2 Cr 2 O} 7, Me 2 CrO 4, R 2 CrO 4, MeCrO 3 Cl, CrO 2 Cl 2 (3) nitric acid and related compounds HNO ₃ , N ₂ O ₄ , N ₂ O ₃ , N ₂ O, Cu (NO ₃ ) ₂ , Pb (NO ₃ ) ₂ , AgNO ₃ , KNO
_{3, NaNO 3, NH 4 NO} 3 , etc. (4) halogens _{F 2, Cl 2, Br 2} , I 2 , etc. (5) peroxides _{H 2 O 2, Na 2 O} 2, BaO 2, ZnO 2, K ₂ O ₂ , Na ₂ O ₂ , CaO _2, etc. (6) Peroxoic acids Me ₂ S ₂ O ₈ , Me ₂ SO ₅ , HCO ₃ H, etc. (7) Oxygen acids MeClO, MeBrO, MeIO, MeClO ₃ , MeBrO ₃ , MeIO ₃ , MeClO ₄ , HIO ₄ , M
e ₃ H ₂ IO ₆ , MeIO ₄ etc. (8) Metal salts FeCl ₃ , CuSO ₄ , CuCl ₂ , SnCl ₄ , ZnCl ₂ etc. (9) Oxygens Air, oxygen, ozone etc. (10) Oxides CeO ₂ , AgO, CuO, BiO ₂ , OsO ₄ , SeO ₂ , MnO ₂ , SnO ₄ , AsO ₂ , FeO, CaO
In the above formula, Me represents a monovalent metal, and R represents an alkyl, alkenyl, allyl, or alkylallyl group having 1 to 20 carbon atoms.

Organic compounds (1) Peroxo acids C ₆ H ₅ CO ₃ H, CH ₃ CO ₃ H, C ₆ H ₄ (CO ₃ H) ₂ , CF ₃ CO ₃ H, etc. (2) Metal salts Copper acetate, zinc acetate, citric acid Copper citrate, zinc citrate, copper succinate, zinc succinate, zinc malonate, zinc ascorbate, iron ascorbate, etc. (3) Dyes aniline black, ursole, aminophenol, etc. (4) Antioxidants and antioxidants Quinones, aminos, phenols, etc. (hydroquinone, naphthoquinone, anthraquinone, phenol-β-
Naphthylamine, vitamin E, sezamol, vitamin C, quercetin, dibutyloxytoluene, butyloxyanisole, ethyl protocatechuate, guaiac, fludihydroguaiaretins, butylhydroxytoluene, β-naphthol, phenyl-α-naphthylamine,
(5) peroxides dialkyl peroxides, acyl peroxide compounds, benzoyl peroxide, lauroyl peroxide, etc. (6) redox reagents methyl viologen, neutral red, Janus Green, Toluidine Blue, Diphenylamine, Ethyl Nile Blue, Methyl Capryl Blue, Phenylanthranilic acid, N-Methyldiphenylamine-p-sulfonic acid,
Methylene blue, phenosafranine, etc. (7) Vitamin coenzyme vitamin _{K 1 to 5,} vitamin A, vitamin _{B 1, B 2, B 6} , B 12,
Vitamin C, α-lipoic acid, NAD, NADP, etc.In the present invention, various combinations of the deodorant active ingredient and the oxidizing agent or reducing agent are selected, for example, by mixing the deodorizing active ingredient with the oxidizing agent or reducing agent. May be added to the deodorant by mixing the active ingredient and the oxidizing agent or reducing agent separately or separately into the product, and then mixed and activated at the time of use. Can also be adopted.

In addition, an active deodorant component activated by causing an oxidizing agent or a reducing agent to act on the active deodorant component can be blended. As a method for obtaining the activated deodorant active ingredient, for example, when the oxidizing agent or the reducing agent is a gas, it is introduced into the solution containing the deodorizing active ingredient for about 3 minutes to 24 hours. After adding it, a method of stirring for about 1 minute to 6 hours can be adopted. After the treatment, if necessary, the solution can be dried to recover a solid activated deodorant active ingredient.

The amount of the deodorant active ingredient used in the present invention varies depending on the type of the deodorant, etc., but is 0.0001 to 50% by weight, particularly 0.001 to 10% by weight, based on the solid content of the plant extract, based on the total amount of the deodorant. It is preferable that

Further, the oxidizing agent or the reducing agent is not particularly limited,
The content is preferably 0.00001 to 10% by weight, more preferably 0.0001 to 2% by weight, based on 1 g of the deodorant active ingredient.

The deodorant active ingredient of the present invention may be used alone or in combination with another deodorant active ingredient.

The deodorant according to the present invention can be prepared in various dosage forms. For example, a solution in which the deodorant active ingredient of the present invention and an oxidizing agent or a reducing agent are dissolved in an appropriate solvent, or a paste,
Granular, block, microcapsule, etc.
Those prepared in the desired form may be used.

Further, as other components of the deodorant of the present invention, appropriate components according to the type, dosage form, and the like of the deodorant can be blended. For example, when used as an oral deodorant for prevention of bad breath and removal of bad breath, dibasic calcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, amorphous silica, crystalline silica,
Abrasives such as aluminosilicate, aluminum oxide, aluminum hydroxide, resin (compounding amount is usually 20 to 60% by weight), binders such as sodium carboxymethylcellulose, hydroxyethylcellulose, alginate, carrageenan, gum arabic, polyvinyl alcohol (usually) 0.
3-5% by weight), thickeners such as polyethylene glycol, sorbitol, glycerin and propylene glycol (usually 10-70% by weight), sodium lauryl sulfate, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, lauryl Foaming agents such as sodium sulfoacetate, sodium N-lauroylsarcosinate, N-acylglutamate, sodium N-myristoylsarcosinate, N-acylalanine, lauric acid diethanolamide, sucrose fatty acid ester, etc.
0.1 to 5% by weight), essential oils such as peppermint and spearmint, flavors such as l-menthol, carvone, eugenol, anethole and the like, saccharin sodium, steviozide, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, p-methoxycin Ingredients such as a sweetener such as namic aldehyde and a preservative are blended, and these components are mixed with water and manufactured according to a conventional method. Also, in mouthwashes such as mouthwashes and the like, components according to the properties of the product are appropriately compounded. In these oral compositions, lysozyme chloride,
Dextranase, lytic enzyme, mutanase, chlorhexidine, sorbic acid, alexidine, hinokitiol,
Cetylpyridinium chloride, alkyl glycine, alkyl diaminoethyl glycine salt, allantoin, ε-
Contains active ingredients such as aminocaproic acid, tranexamic acid, azulene, sodium monofluorophosphate, sodium fluoride, stannous fluoride, water-soluble primary or secondary phosphates, quaternary ammonium compounds, and sodium chloride You can also.

Also, in the case of household and industrial deodorants used for bad odors generated in houses and the environment, components used in ordinary deodorants according to the types and the like can be blended. For example, ketones, activated carbon, An adsorbent such as silica gel and alumina can be blended.

Effect of the Invention As described above, the deodorant of the present invention has superior deodorizing power as compared with a conventional deodorant using an effective deodorant alone, and is generated in a human body, a house, an environment, and the like. It can be widely used as a deodorant against malodor.

Further, according to the present invention, the compounding amount of the deodorant active ingredient can be reduced, and problems such as coloring, deterioration of taste, precipitation, etc. are also improved. Can be widely applied.

Hereinafter, experimental examples of the deodorant active ingredient according to the present invention will be described.

[Experimental Example 1] A test of 25 mg in volume prepared by dissolving 0.1 mg of the plant extract shown in Table 1 and 0.5 mg of an oxidizing or reducing agent in 2.5 ml of 0.05 M phosphate buffer at pH 7.0. The mixture was placed in a tube, 0.5 ml of 1 ppm methyl mercaptan was further added thereto, and the mixture was sealed and reacted at 36 ° C. for 6 minutes.

After completion of the reaction, the amount of methyl mercaptan in the head space of the test tube was measured by gas chromatography.

The deodorization rate of methyl mercaptan of these specimens was calculated according to the following formula, using only phosphate buffer in a test tube as a control.

S: The amount of methyl mercaptan in the sample headspace C: Control の In addition, when each of the deodorant active ingredient and the oxidizing agent or the reducing agent in Table 1 was used alone, the same treatment was performed as described above. The amount of methyl mercaptan in the headspace was measured, and the individual deodorization rate was calculated for each.

 Table 1 shows the above results.

From the results in Table 1, the deodorization rates (I) and (I ') of the single
The deodorization rate (II) when used in combination was considerably higher than the sum of the above, and it was confirmed that the synergistic action of the two exerted an excellent deodorizing power.

[Experimental Example 2] 100 ml of the plant extract shown in Table 2 (containing about 2 g of extract as a solid content when dried) was subjected to oxygen gas treatment, H ₂ O ₂ treatment and CaO treatment by the following methods. The liquid obtained after the treatment was dried to obtain a deodorant comprising an activated plant extract.

Oxygen gas treatment 25 ° C at a rate of 20 ml / min oxygen gas in 100 ml of plant extract
For 3 hours.

H ₂ O ₂ treatment 1 ml of a 10% H ₂ O ₂ solution was added to 100 ml of the plant extract and stirred at 25 ° C. for 3 hours.

CaO treatment 0.2 g of CaO was added to 100 ml of the plant extract, and the mixture was stirred at 25 ° C. for 3 hours, passed through an ion exchange resin column, and the passed liquid was collected.

Next, Experimental Example 1 of the activated plant extract deodorant was used.
The deodorization rate of methyl mercaptan was determined in the same manner as in the above. In addition, the deodorization rate of methyl mercaptan when each non-activated plant extract was used alone was similarly measured and calculated.

 Table 2 shows the above results.

In addition, the thing which carried out the above-mentioned oxidation process with respect to 100 ml of water did not show a residue, even if the liquid after a process was dried, and the measurement of the deodorizing power was impossible.

From the results shown in Table 2, the activated plant extract deodorant obtained by reacting the plant extract with an oxidizing agent or a reducing agent in advance has a deodorizing effect as compared with the case where the plant extract is used alone. It was confirmed that it was excellent.

Hereinafter, the present invention will be described specifically with reference to examples.
The present invention is not limited to the following examples.

 In addition, in the following examples, all% show weight%.

[Example 1] Toothpaste Aluminum hydroxide 43% Glycerin 20 Sodium carboxymethylcellulose 2 Sodium lauryl sulfate 2 Fragrance 1 Sodium saccharin 0.1 Ogon 30% ethanol extract 0.15 Quicklime (CaO) 0.05 N-Lauroyl sarcosine sodium 0.2 Water Residue 100.0% [Example 2] Toothpaste Dibasic calcium phosphate 45.0% Silicic anhydride 2.0 Sodium carboxymethylcellulose 0.3 Carrageenan 0.8 Sorbit 20.0 Propylene glycol 2.0 Sodium lauryl sulfate 1.5 Activated product of ethanol extract of eleuthero (oxygen gas treatment) 0.05 Perfume Appropriate amount Water remaining 100.0% [ Example 3] Liquid dentifrice Sodium polyacrylate 50% Glycerin 30 Fragrance 0.9 Sodium saccharin 0.1 Alame aqueous extract 0.25 Benzoyl peroxide 0.05 Ethanol 3 N-lauroy Sarcosine 0.04 Water remaining Total 100.0% Thin sodium 0.2 Linoleic acid Example 4 Mouthwash Ethanol 20% Perfume 1 Saccharin sodium 0.05 plantago 30% ethanol extract 0.2 over sodium 0.1 sodium monofluorophosphate 0.1 Chlorhexidine hydrochloride acid 0.01 Lauryl diethanolamide 0.3 Water balance 100.0% [Example 5] Lozenge gum arabic 6% Palatinose 30 Maltitol 20 Isomaltose 22 Gelatin 3 Perfume 0.2 Rhubarb 50% ethanol extract 0.5 Zinc chloride 0.1 Water Balance 100.0% [Example 6] Chewing gum gum base 20 % sugar 16 isomaltose 20 maltose 20 corn syrup 11.3 Starch syrup 11.5 flavors 0.5 rosemary methanol extract 0.5 hemoglobin 0.2 total 100.0% example 7 toilet soap carboxymethylcellulose 8% Fat agent 2 soap base 50 triethanolamine lauryl sulfate 30 7-hydroxy 6,8-dimethoxy coumarin -D- Clicquot side 0.01 times 30% ethanol extract 0.3 copper citrate 0.01 dye, perfume qs water balance Total 100.0% Example 8] Hand lotion Cetyl monostearate 1.0% Isopropyl palmitate 4.0 Polyethylene glycol 100 distearate 2.0 Glycerin 8.0 Sodium cetyl sulfate 5.0 Birch water extract 1.0 Manganese dioxide 0.1 Dye, flavor, preservative Appropriate amount Water remaining 100.0% [Example 9] Lotion Lotion Citric acid 0.1% Zinc paraphenolsulfonate 0.2 Sorbit 2.0 Glycerin 3.0 Polyoxyethylene (20EO) oleyl ether 1.0 Ethanol 15.0 Clove water extract 2.0 Zinc ascorbate 0.05 Perfume, preservative Appropriate amount of water Residue 100.0% [Example 10 After sales Eving lotion Ethanol 40.0% Menthol 0.05 Benzyl alcohol 0.25 Glycyrrhetinic acid 0.05 Polyoxyethylene hydrogenated castor oil mono-vilogultamate monoisostearate 0.7 Fragrance 0.1 Timpi 30% ethanol extract 0.2 Quercetin 0.1 Water Residual 100.0% [Example 11] Liquid shampoo Glycerin 10.0% Sodium alkylbenzenesulfonate 20.0 Chrome 30% Activated ethanol extract (ozone gas treatment) 0.05 Perfume Appropriate amount of water Residual 100.0% [Example 12] Hair rinse Stearyl dimethyl ammonium chloride 3.0% Glycerin monostearate 3.0 % ethanol extract 0.2 zinc acetate 0.05 colorants 0.05 perfume 0.05 water remaining total 100.0% example 13 garbage liquid deodorant ethanol 70% site Polygala ethanol extract 1 hydroquinone 0.1 perfume 1 water remaining 100.0% Example 14 activator (hydrogen peroxide treatment) of the foot spray 50% ethanol dichlorodifluoromethane 49.9 Umitoranoo of n- butanol extractive 0.1 Total 100.0% Example 15 Microencapsulation oral gelatin in hot water 100ml After dissolving 5 g of the powder, 2.0 g of oak dried extract and 0.1 g of zinc succinate were added and dispersed well.

On the other hand, 3: 4 of ethyl acetate: chloroform containing 0.2% polyoxyethylene hydrogenated castor oil as a surfactant
A mixed solution was prepared and cooled sufficiently. Next, the above-mentioned dispersion liquid was dropped and dispersed in this mixed solution, and then passed to obtain microcapsules.

Example 16 Enteric-coated microcapsules 2 g of dried rosemary extract granules were added to cytochrome a0.1
g, and then sprayed with an aqueous sodium bicarbonate solution of cellulose acetate phthalate containing sodium pyrosulfate to obtain microcapsules having 0.3-2% by weight of cellulose acetate phthalate adhered to the dried rosemary extract.

The microcapsules were subjected to a disintegration test according to the disintegration test method of the Japanese Pharmacopoeia (Tenth Edition), and were found to be enteric capsules that disintegrate in the second liquid (pH of about 7.5).

[Example 17] Spray for pet ethanol 50% Dichlorodifluoromethane 49.95 Activated product of ethanol extract of marjoram (hydrogen peroxide solution treatment) 0.05 total 100.0% [Example 18] Indoor deodorant ethanol 20% rhubarb 50% ethanol extraction Activated substance (potassium permanganate treatment) 0.05 Perfume Appropriate amount Water remaining 100.0%

Claims (3)

(57) [Claims] 1. A deodorant comprising a combination of a deodorant active ingredient comprising a solvent extract of a plant selected from red algae plants, brown algae plants, gymnosperms and angiosperms, and an oxidizing agent or a reducing agent. 2. The deodorant according to claim 1, wherein an effective component of the deodorant is treated with an oxidizing agent or a reducing agent in advance. 3. The deodorant according to claim 1, wherein the active ingredient for deodorization and an oxidizing agent or a reducing agent are mixed and blended.