JPS647964B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention is related to the following plants: Ryoukiyou, Nindo, Kashiyu, Kuromoji, Nantenjitsu, Hawthorn, Botanhi, Koujiyu, Onji, and Annin. (Kiyounin), Momohin (Tonin), Shiso (Perilla)
The present invention relates to an oral composition that suppresses the formation of dental plaque and prevents dental caries and periodontal disease by incorporating an organic solvent extract (crude extract) of a plant selected from Japanese persimmon leaves and persimmon leaves. Dental plaque that adheres to the tooth surface is made up of about 70% bacteria, about 20% polysaccharide formed by bacteria, and about 10% food residue, and is firmly stuck to the tooth surface. The acid stored inside demineralizes the enamel, and the bacteria and toxins produced are said to cause gingivitis, periodontitis, and even pyorrhea, two major oral diseases. It is attracting attention as a cause of caries and alveolar pyorrhea. This dental plaque is formed by oral bacteria, mainly Streptococcus miutans, using sucrose present in the oral cavity. That is, Streptococcus miutans produces GTF (glucosyltransferase, dextran synthase), which synthesizes sticky polysaccharides such as dextran and mutan from sucrose. This synthesized polysaccharide then attracts Streptococcus miutans and other bacteria (pathogens), forming dental plaque with a certain bacterial flora. Furthermore, bacteria such as Streptococcus miutans produce acids using various sugars, and this acid demineralizes the enamel surface by staying in the walls of polysaccharides and bacteria. Furthermore, the dead bacteria and the various substances and toxins produced have an adverse effect on the gums and act as a cause of alveolar pyorrhea. Therefore, suppressing and preventing the formation of dental plaque is
This is extremely effective in preventing caries and periodontal disease. Taking these points into consideration, the present inventors have investigated caries, caries,
We conducted intensive research on oral compositions suitable for the prevention of periodontal diseases, and screened various plants that are mainly used in Chinese herbal medicine formulations as natural additives. As a result, we found that organic solvent extracts of the 13 plants listed above are effective against streptococcus. We have discovered that the formation of dental plaque by GTF derived from Kotsucus miutans is suppressed, and that the organic solvent extract is therefore suitable as an active ingredient in oral compositions for the prevention of dental caries and periodontal diseases. He came up with an invention. The present invention will be explained in detail below. The oral composition according to the present invention includes toothpaste, toothpaste,
It is used as toothpaste such as water toothpaste, mouthwash, pastilles, pasta, liniment, chewing gum, gargling tablets, etc.The active ingredients include ryojiang, ninto, heshugarasu, kuromoji, nantenmi, yamaseiko, and peony. It is made by blending one or more organic solvent extracts of , incense, toshi, apricot kernel, peach kernel, perilla, and persimmon leaf. As the organic solvent used for extracting the plants, lower alcohols such as methanol and ethanol, polar solvents such as acetone, ethyl ether, and ethyl acetate, and nonpolar solvents such as benzene, hexane, and petroleum ether can be used. Mixed solvents such as aqueous ethanol may also be used. The organic solvent extract used as an active ingredient in the present invention is obtained by extracting the above-mentioned plants with one type or a mixture of two or more of these organic solvents, or a mixture of these organic solvents and water, and removing the extraction residue. can be produced by distilling off the solvent from the extract, if necessary. Note that a known method can be used as the extraction method, for example, a method such as digesting the dried powder of the plant in an organic solvent can be used. The amount of the organic solvent extract incorporated into the oral composition is 0.001 to 5% (wt%, same hereinafter) of the total,
In particular, it is preferably 0.01 to 2%. As other components of the present invention, appropriate components are used depending on the type of oral composition. For example, in the case of toothpaste, dibasic calcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, amorphous silica, crystalline silica, aluminosilicate, aluminum oxide, aluminum hydroxide, abrasives such as resin, carboxylic Methylcellulose, hydroxyethylcellulose, alginate, carrageenan, gum arabic,
Binder such as polyvinyl alcohol, thickening agent such as polyethylene glycol, sorbitol, glycerin, propylene glycol, sodium lauryl sulfate, sodium dodecylbenzenesulfonate,
Hydrogenated Coconut Fatty Acid Monoglyceride Sodium Monosulfate, Sodium Lauryl Sulfoacetate,
Foaming agents such as sodium N-lauroyl sarcosinate, N-acyl glitamate, and sucrose fatty acid esters, essential oils such as peppermint and spearmint, fragrance materials such as l-menthol, carvone, eugenol, and anethole, and saccharin. It is produced by mixing ingredients such as sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, sweeteners such as p-methoxycinnamic aldehyde, preservatives, etc. with water and according to a conventional method. Furthermore, in mouthwashes and other mouthwashes, ingredients are appropriately blended depending on the properties of the product. In the present invention, in addition to the above-mentioned organic solvent extract of plants, lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexidine, sorbic acid, alexidine, hinokitiol, cetylpyridinium chloride, alkylglycine, alkyldiaminoethylglycine are used. Salt, allantoin, ε-aminocaproic acid, tranexamic acid, azulene, vitamin E, sodium monofluorophosphate, sodium fluoride, fluoride 1
Active ingredients such as tin, water-soluble primary or secondary phosphates, quaternary ammonium compounds, sodium chloride, etc. can also be incorporated. The oral composition according to the present invention contains one or more of the organic solvent extracts of the 13 plants mentioned above, thereby effectively inhibiting the formation of dental plaque due to GTF derived from Streptococcus miutans. suppress,
Therefore, the occurrence of dental caries and periodontal disease can be effectively prevented. Next, experimental examples will be shown to specifically explain the effects of the present invention. Experimental example: Add 300ml of methanol to 80g of dried ginger powder,
The mixture was refluxed for 1 hour on a 70-80°C water bath with a condenser attached. Next, the methanol fraction was separated, fresh methanol was added to the residue, and the same reflux was repeated twice, for a total of three extraction operations. The methanol extract was concentrated under reduced pressure to form a dark brown paste.
5.7g was obtained. The other plants shown in Table 1 were operated in the same manner as above to obtain methanol extracts of each plant. Next, the above extract was used as a test sample, and its degree of inhibition of plaque formation was evaluated by the reaction adhesion method described below. Reactive deposition method 1% sucrose, 0.01% fungicide (NaN ₃ ) and heat sterilized Streptococcus miutans
0.05M phosphate buffer (PH7.0) containing 6715 strains of bacteria
0.1% of the above test sample was added to the solution, and to this was added the extracellular enzyme containing GTF of Streptococcus miutans strain 6715, which had been prepared in advance.
℃ for 16 hours. After the reaction, wash twice with water, then add the same amount of water as the reaction system, perform ultrasonic treatment for about 20 seconds to uniformly suspend the plaque, and then use a photometer to disperse the plaque at 550 nm. The absorbance (turbidity) was measured to determine the amount of attached plaque. The results are shown in Table 1. The results are expressed as a percentage, with the amount of plaque attached to the control to which no test sample was added as 100%.

[Table] From the above results, it was found that the methanol extracts of each plant shown in Table 1 effectively suppress the formation of dental plaque. Examples are shown below. Note that all % indicates weight %. Furthermore, in the following examples, methanol crude extracts of plants were used. Example 1 Toothpaste dicalcium phosphate dihydrate 50.0% Glycerin 20.0% Carboxymethyl cellulose 1.0 Sodium lauryl sulfate 1.0 Flavor 1.0 Saccharin 0.1 Nantenji methanol extract 0.2 Sodium fluoride 0.1 Water Remaining 100.0% Example 2 Kneading Toothpaste dicalcium phosphate dihydrate 50.0% Sorbit 10.0 Glycerin 10.0 Carboxymethyl cellulose 1.0 Sodium lauryl sulfate 2.0 Fragrance 1.0 Satucalin 0.1 Ginger methanol extract 0.1 Botanpi methanol extract 0.1 Sodium monofluorophosphate 0.3 Ethanol 2.0% Tanase 0.1 Water remaining 100.0% Example 3 Toothpaste calcium carbonate 50.0% Glycerin 20.0 Carrageenan 0.5 Carboxymethyl cellulose 1.0 Lauryl diethanolamide 1.0 Sucrose monolaurate 2.0 Fragrance 1.0 Satucalin 0.1 Methanol extract of Siberian algae 0.15 Chlorhexidine 0.005 Dextranase 0. 01Wed Remaining 100.0% Example 4 Toothpaste dicalcium phosphate dihydrate 50.0% Glycerin 20.0% Carboxymethylcellulose 2.0 Sodium lauryl sulfate 2.0 Fragrance 1.0 Satukarin 0.1 Methanol extract of Ninduong 0.1 Methanol extract of Heshouwu 0.1 Chlorhexidine 0.01 Water Remaining 100.0% Example 5 Toothpaste Silicic anhydride 30.0% Glycerin 30.0 Sorbit 20.0 Carboxymethyl cellulose 1.0 Sodium lauryl sulfate 2.0 Fragrance 1.0 Saccharin 0.1 Fragrance methanol extract 0.1 Apricot kernel methanol extract 0.1 Ethanol 2.0% Water Remaining 100.0% Example 6 Tooth powder Magadei Calcium diphosphate dihydrate 50.0% Calcium carbonate 30.0 Glycerin 10.0 α-olefin sulfonate 1.0 Flavor 1.0 Saccharin 0.1 Toshi methanol extract 0.1 Perilla methanol extract 0.1 Sodium monofluorophosphate 0.1 Dextran 0.5 Water Remaining 100.0% Examples 7 Liquid toothpaste Sodium polyacrylate 50.0% Glycerin 30.0 Fragrance 0.9 Satucalin 0.1% Chlorhexidine 0.01 Shinto winter methanol extract 0.05 Peach kernel methanol extract 0.05 Ethanol 3.0 Linoleic acid 0.05 Water Balance 100.0% Example 8 Mouthwash ethanol 20.0% Fragrance 1.0 Satucalin 0.05 Sodium monofluorophosphate 0.1 Chlorhexidine 0.01 Lauryl diethanolamide 0.3 Nantenmi methanol extract 0.05 Persimmon leaf methanol extract 0.05 Water Balance 100.0% Example 9 Gargle tablet Sodium bicarbonate 54.0% Sodium diphosphate 10.0 Polyethylene glycol 3.0 17.6 sodium sodium citric acid (absolute water) 13.6 fragrance 2.0 oleic acid 0.1 oleic acid 0.1 sodium olorinate 0.1 chlorhexidine 0.05 chlomethanol extracted 0.1 Kakoji methanol extract 0.05 100.0 % Execution Propilen Glycol 4.0 Stearyl Alcohol 8.0 Polyethylene glycol 4000 25.0 Polyethylene glycol 400 37.0 Almond kernel methanol extract 0.1 Sucrose stearate 0.5 Dextranase 1.0% water Balance 100.0% Example 11 Chewing gum gum base 43.8% Calcium carbonate 2.0 Starch syrup 15.0 Powdered sugar 30.0 Sucrose Palmitate 1.0 Fructose 4.0 Maltose 3.0 Cromodimethanol extract 0.1 Nantenji extract 0.1 Flavor 1.0 100.0%

Claims (1)

[Claims] 1. Contains one or more organic solvent extracts of plants selected from Ryogyo, Shinto, Heshugarasu, Kuromoji, Nantenji, Yamasako, Botanpi, Koji, Toshi, Almond, Peach, Persimmon, and Persimmon leaves. An oral composition characterized by: