JPH0369883B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a composition for removing bad breath that effectively removes bad breath by using a sage extract and/or a rosemary extract in combination with l-menthol and/or carvone. Oral compositions such as toothpaste and mouthwash are
It is used to clean and clean the inside of the oral cavity and keep the inside of the mouth hygienic.In this case, the oral composition must have the function of removing bad breath that makes people feel uncomfortable. desired. As a result of intensive research into a halitosis-removing composition that has an excellent halitosis-removing effect, the present inventors found that
The inventors have discovered that bad breath can be reliably removed by using sage extract and/or rosemary extract in combination with l-menthol and/or carvone, leading to the present invention. The present invention will be explained in detail below. The present invention provides sage extract and/or rosemary in a composition for removing bad breath such as toothpaste, moisturized toothpaste, powdered toothpaste, mouthwash, oral pasta, troche, chewing gum, gargling tablet, etc. It is a blend of the extract of 1-menthol and/or carvone. In this case, raw materials used to obtain extracts of sage and rosemary include sage and rosemary powder; residues obtained by extracting oil from these by steam distillation and other essential oil extraction residues; or ethyl sage and rosemary. Oleoresin and its extraction residue obtained by extraction with polar solvents such as ether, ethylene chloride, dioxane, acetone, lower alcohols such as ethanol and methanol, ethyl acetate, propylene glycol, glycerin, and water; sage and rosemary n-hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene,
An oleoresin obtained by extraction with a non-polar solvent such as benzene and an extraction residue thereof is used. When obtaining extracts of sage and rosemary from these raw materials, one or more of these raw materials may be mixed with a polar solvent and/or a non-polar solvent (the solvents listed above are used). The extract (extract liquid or the product from which the solvent has been distilled off)
Collect. In the present invention, this extract can be used as it is, but it is also possible to use a steam distillation residue obtained by subjecting this extract to a steam distillation treatment, or a steam distillation residue obtained by subjecting this extract or the steam distillation residue to activated carbon, diatomaceous earth, or acid clay. After treating the extract with an adsorbent,
Residues obtained from steam distillation are also sage,
It can be suitably used as a rosemary extract. Note that a known method can be used as the extraction method, for example, a method such as digesting dry powder of sage or rosemary in a solvent can be used. In this case, the solvent is preferably an organic solvent, and an organic solvent extract obtained by extracting sage or rosemary with an organic solvent is more effective. In addition, in the present invention, as the extract of sage and rosemary, one type obtained by the above-mentioned method may be used, or two or more types may be used in combination. Further, the amount of the extract of sage and rosemary added to the composition for removing bad breath is preferably 0.0005% (weight %, same hereinafter) to 5%, particularly 0.05% to 2% of the total. The present invention uses l-menthol and/or carvone in combination with the above-mentioned sage extract and/or rosemary extract, so that they act synergistically to eliminate CH ₃ SH, which is the main cause of bad breath.
It is possible to reliably eliminate bad odor and suppress the occurrence of bad breath. On the other hand, using sage extract or rosemary extract alone
The bad odor of CH ₃ SH cannot be completely removed,
Further, even if sage extract or rosemary extract is used in combination with other essential oils or fragrance ingredients such as vanilla oil or methyl anthranilate, a sufficient effect of removing bad breath cannot be obtained, and the object of the present invention cannot be achieved. L-menthol and carvone used in the present invention may be isolated from essential oils or synthesized, and essential oils containing l-menthol and carvone,
For example, mint oil may be used as is.
Japanese mint oil is used as mint oil.
Mint Oil), Peppermint Oil,
Mitcham Peppermint
Oil, English Black Mint Oil and English
White Mint Oil), Spearmint Oil
oil, native species, and Scotch species). Particularly preferred among these are those extracted from the species M.piperita L.. The above mint oil may be used alone or in combination with two or more thereof, or may be used in combination with isolated or synthetic l-menthol or carvone. Further, the blending amounts of l-menthol and carvone are preferably 0.01 to 2%, particularly 0.05 to 1%, based on the total composition. In addition, in the present invention, other essential oils and fragrance materials may be blended in addition to l-menthol and carvone. As other components of the present invention, appropriate components are used depending on the type of the composition for removing bad breath. For example, in the case of toothpaste, dibasic calcium phosphate,
Abrasives such as dihydrates and anhydrides, calcium carbonate, calcium pyrophosphate, calcium sulfate, insoluble sodium metaphosphate, amorphous silica, crystalline silica, aluminosilicate, aluminum hydroxide, aluminum oxide, resin, etc. (in the usual amount) 20〜
60%), binders such as carboxymethyl cellulose, hydroxyethyl cellulose, alginate, carrageenan, gum arabic, polyvinyl alcohol (0.3-5%), thickeners such as polyethylene glycol, sorbitol, glycerin, propylene glycol (10-70%), etc. %), Sodium Lauryl Sulfate, Sodium Dodecylbenzenesulfonate, Hydrogenated Coconut Fatty Acid Monoglyceride Sodium Monosulfate, Sodium Lauryl Sulfoacetate, Sodium N-Lauroyl Sarcosinate, N
- Foaming agents such as acyl glutamate, lauryl diethanolamide, sucrose fatty acid ester (0
~5%), plus saccharin sodium, stevioside, neohesperidyl dihydrochalcone,
It is produced by mixing ingredients such as sweeteners such as glycyrrhizin, perillartin, p-methoxycinnamic aldehyde, and thaumatin, and preservatives with water and following a conventional method. Furthermore, in mouthwashes and other mouthwashes, ingredients are appropriately blended depending on the properties of the product. In addition, the composition for removing bad breath of the present invention includes lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexidine or a salt thereof, sorbic acid,
Alexidine, hinokitiol, cetylpyridinium, chloride, alkylglycine, alkyldiaminoethylglycine salt, allantoin, ε-
Aminocaproic acid, tranexamic acid, azulene,
Vitamin E, sodium monofluorophosphate, sodium fluoride, stannous fluoride, water-soluble primary or secondary phosphates, quaternary ammonium compounds,
Active ingredients such as sodium chloride can also be blended. Therefore, the breath odor removing composition according to the present invention uses sage extract and/or rosemary extract together with l-menthol and/or carvone, so that they act synergistically. Tsute
This effectively suppresses bad breath caused by the foul odor of CH ₃ SH. Next, experimental examples will be shown to specifically explain the effects of the present invention. [Experimental example] 300 ml of methanol was added to 100.0 g of dry sage powder, and the mixture was refluxed for 1 hour on a water bath at 70 to 80°C with a cooling tube attached. Next, the methanol fraction was separated, fresh methanol was added to the residue, and the same reflux was repeated twice, for a total of three extraction operations. The methanol extracts were collectively concentrated under reduced pressure to obtain 27.4 g of a dark-colored paste. Further, 150 ml of methanol was added to 30 g of dried rosemary powder, and the mixture was refluxed for 1 hour on a water bath at 70 to 80°C with a cooling tube attached. The following procedure was carried out in the same manner as in the case of sage to obtain 7.3 g of a dark greenish-brown solid. Other solvents were operated in the same manner as above to obtain various extracts of sage and rosemary. Table 1 shows the extraction results.

【table】

[Table] Next, human saliva was centrifuged (5000 rpm, 15 minutes,
4℃), after removing solids (white blood cells, bacterial cells),
Transfer 2.5 ml of that to a test tube with a diameter of 25 mm and a height of 220 mm, add sage and rosemary extracts of various concentrations and ethanol to make 1.0 ml, and then add fragrance ingredients (essential oils). Added at various concentrations. Add to this 0.5 ml of an aqueous solution containing CH ₃ SH (100 ng of
(containing CH ₃ SH), cap immediately,
Incubation was performed at 37°C for 5 minutes. After the reaction, the cap was opened and the four members of the panel discussed
Sensory evaluation was performed based on the following evaluation criteria using the odor of CH ₃ SH as an index. Evaluation criteria: 3 points: There is a strong CH ₃ SH odor. 2 points: There is a smell of CH ₃ SH. 1 point: I doubt whether it is the smell of CH ₃ SH. 0 points: There is no smell of CH ₃ SH. The results are shown in Table 2. The results were shown as the overall score of the four panelists.

[Table] From the results in Table 2, it is clear that when sage and rosemary extracts are used together with l-menthol or carvone, they act synergistically, and CH ₃ SH
It has been found that it eliminates the smell of Examples are shown below. Example 1 Toothpaste dicalcium phosphate dihydrate 50% Glycerin 20 Carboxymethyl cellulose 1.0 Sodium lauryl sulfate 1.0 L-menthol 0.5 Anethole 0.2 Sage methanol extract 0.05 Saccharin 0.1 Sodium fluoride 0.1 Allantoin 0.1 Water Remaining 100.0% Implementation Example 2 Toothpaste dicalcium phosphate dihydrate 50% Sorbit 10% Glycerin 10 Sodium lauryl sulfate 2.0 Carboxymethyl cellulose 1.0 Carvone 0.7 Eugenol 0.05 Sage 80% ethanol extract 0.1 Sodium monofluorophosphate 0.3 Ethanol 2.0 Satucalin 0.1 Mutanase 0.1 water remaining 100.0% Example 3 Toothpaste calcium carbonate 50% Glycerin 20 Carrageenan 0.5 Carboxymethyl cellulose 1.0 Lauryl diethanolamide 1.0 Sucrose monolaurate 2.0 Peppermint oil 0.8% Sage petroleum ether extract 0.1 Satucalin 0.1 Chlorhexidine hydrochloride 0.005 Dextranase 0 .01 Azulene 0.1 Water Balance 100.0% Example 4 Toothpaste dicalcium phosphate dihydrate 50% Glycerin 20 Carboxymethyl cellulose 2.0 Sodium lauryl sulfate 2.0 Spearmint oil 1.0 Water extract of sage 0.1 Chlorhexidine gluconate 0.01 Satucalin 0.1 Glycyrrhizic acid 0.2 Bentonite 0.5 Water Balance 100.0% Example 5 Toothpaste Silicic anhydride 30% Glycerin 30 Sorbit 20 Sodium lauryl sulfate 2.0 Carboxymethyl cellulose 1.0 L-menthol 0.5 Carvone 0.5 Anethole 0.2 Satucalin 0.1 Rosemary acetone extract 0.1 Tranexamic acid 0.1 water Remaining 100.0% Example 6 Oral Pasta Polyoxyethylene Monostearate 2.0% Sorbitan Monooleate 2.0 Cetyl Alcohol 2.0 Palmityl Alcohol 3.0 Propylene Glycol 15.0 Carboxymethyl Cellulose 5.0% Gelatin 1.0 Satucalin 0.2 Sage Methanol Extract 0.1 Peppermint Oil 0.5 Spearmint Oil 0.5 Lysozyme chloride 5000 units/g Chlorhexidine hydrochloride 0.01% Water Balance 100.0% Example 7 Oral pasta glycerin monolaurate 3.0% Oleyl alcohol 5.0 Polyethylene glycol 15.0 White petrolatum 3.0 Monosodium N-palmitoylglutamate
0.5 Hydroxyethylcellulose 5.0 Sage ethylene chloride extract 0.05 Tocopherol acetate 0.1 Chlorhexidine hydrochloride 0.01 Satucalin 0.2% Japanese seed pepper oil 0.7 Carvone 0.5 Anethole 0.3 Eugenol 0.1 Water remaining 100.0% Example 8 Mouth rinse ethanol 20.0% Satucalin 0.05 l-menthol 1.5 carvone 0.5 Linalool 0.1 Sodium monofluorophosphate 0.1 Chlorhexidine gluconate 0.01 Lauryl diethanolamide 0.3 Sage n-hexane-methanol (1:1)
Extract 0.1 Glycyrrhizinate 0.1 Allantoin 0.1 Water Remaining 100.0% Example 9 Liquid toothpaste glycerin 35.0% Monosodium N-cocoylglutamate
1.5 Carrageenan 1.5 Katupring Sugar 2.0 Peppermint Oil 0.7 Carvone 0.3 Ethanol 1.0 Sodium Monofluorophosphate 0.5 30% Ethanol Extract of Rosemary 0.05 Chlorhexidine Hydrochloride 0.01 Water Balance 100.0% Example 10 Pastille Gum Arabic 6.0% Glucose 72.0 Gelatin 3. 0 incense Materials 0.2 Dextranase 0.1 Chlorhexidine gluconate 0.01 Sage ethanol extract 0.1% L-menthol 0.1 Spearmint oil 0.1 Celery methanol extract 0.1 Water Balance 100.0% Example 11 Chewing gum gum base 40.0% Calcium carbonate 2.0 Starch syrup 15.0 Powdered sugar 40.0 Peppermint oil 0.2 Dextranase 0.1 Rosemary n-hexane extract 0.1 Water Remaining 100.0% Example 12 Gargle tablet Sodium bicarbonate 54% Sodium diphosphate 10 Polyethylene glycol 3.0 Carvone 1.0% Peppermint oil 1.0 Oleic acid 0.1 Mono Sodium fluorophosphate 0.1 Chlorhexidine hydrochloride 0.05 Sage ethanol extract 0.05 Rosemary ethanol extract 0.05 Allantoin 0.1 Citric acid 17.0 Water Balance 100.0% Example 13 Powdered toothpaste dicalcium phosphate dihydrate 50.0% Calcium carbonate 30.0 Glycerin 10.0 α -Olefin sulfonate 1.0 l-Menthol 1.0 Satucalin 0.1 Sodium monofluorophosphate 0.1 Methanol extract of rosemary 0.1 Dextran 0.5% Water Balance 100.0%

Claims (1)

[Claims] 1. A composition for removing bad breath, characterized by using a sage extract and/or a rosemary extract in combination with l-menthol and/or carvone.