JPS58134013A - Composition for oral cavity application - Google Patents

Abstract

PURPOSE:To provide a composition for oral cavity application, containing the sage extract and/or rosemary extract in combination with l-menthol and/or carvone, exhibiting synergistic effect, and effectively preventing the halitosis. CONSTITUTION:A composition for oral cavity application, such as tooth paste, mouth wash, pasta, troche, gum, gargle tablet, etc. is incORporated with sage extract and/or rosemary extract (0.05-2wt% of the whole composition) in combination with l-menthol and/or carvone. The combined use of the components suppresses the halitosis caused by the ill odor of CH3SH, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides an oral composition that effectively removes bad breath by using a sage extract and/or a rosemary extract in combination with t-menthol and/or carvone. Regarding.

Oral compositions such as toothpaste and mouthwash are used to clean and wash the inside of the oral cavity and keep the inside of the mouth hygienic. It is desired that the device has the function of removing bad breath.

The present inventors have conducted extensive research on oral compositions that have excellent breath odor removal effects, and have found that sage extract and/or rosemary extract are used in combination with t-menthol and/or carvone. The present invention was developed based on the idea that bad breath can be reliably removed.

Below, Akira Honkaji will be explained in detail.

The present invention describes the use of sage extract and/or rosemary in oral compositions such as toothpastes, moisturized toothpastes, powdered toothpastes, mouthwashes, oral pastas, troches, chewing gums, and gargle tablets. It is a blend of extract and t-menthol and/or carvone.

In this case, the raw materials used to obtain the extracts of sage and rosemary include sage and rosemary powder, residues obtained by extracting oil from these by steam distillation, and other essential oil extraction residues; or sage and rosemary IJ. −
Ethyl ether, ethylene chloride, dioxane,
Oleoresin and its extraction residue obtained by extraction with lower alcohols such as acetone, ethanol, and methanol, and polar solvents such as ethyl acetate, propylene glycol, glycerin, and water; sage, rosema IJ-'cn
-Hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,
Those selected from oleoresins obtained by extraction with nonpolar solvents such as 2-dichloroethane, toluene, and benzene, and their extraction residues are used. When obtaining extracts of sage and rosemary from these raw materials, one or more of these raw materials may be mixed with a polar solvent and/or a non-polar solvent (the solvents listed above are used). The extract (extract liquid or extract from which the solvent has been distilled off) is collected. In the present invention, this extract can be used as it is, but it is also possible to use a steam distillation residue obtained by steam distilling this extract, or a steam distillation residue obtained by steam distilling this extract, or a steam distillation residue obtained by subjecting this extract or the steam distillation residue to activated carbon, diatomaceous earth, acid clay 4. the extract treated with an adsorbent, and the extract treated with an adsorbent,
Residues obtained by steam distillation can also be suitably used as extracts of sage and rosemary. Note that a known method can be used as the extraction method, for example, a method such as digesting dry powder of sage or rosemary in a solvent can be used. In this case, the solvent is preferably an organic solvent, and an organic solvent extract obtained by extracting sage or rosemary with an organic solvent is highly effective.

In addition, in the present invention, even if one kind obtained by the above method is used as the extract of sage and rosemary, two
You may use more than one species in combination.

The amount of extracts of Mata, sage, and rosemary to be added to the oral composition is preferably 0.0005% (weight%, same hereinafter) to 5%, particularly 0.05% to 2% of the total. .

When used in combination with Rudane, they act synergistically to eliminate the bad odor of CH3SH, which is the biggest cause of bad breath, and effectively suppress the occurrence of bad breath. On the other hand, even if sage extract or rosemary extract is used alone, it is not possible to completely remove the bad odor of CH and SH, and sage extract or rosemary extract cannot be used alone with other essential oils or fragrance ingredients. For example, even if used in combination with vanilla oil, methyl anthranilate, etc., a sufficient breath odor removing effect cannot be obtained and the object of the present invention cannot be achieved.T-menthol and carmen used in the present invention are isolated from essential oils. The mint oil may be either synthesized or synthesized, and essential oils containing t-menthol and cargane, such as mint oil, may be used as they are. Examples of mint oil include Japanese Mint Oil, J/'
P-mint oil (PePpermint 01l), Mitcham peppermint oil (PePpermint 01l)
tOil.

English Black Mint Oll and E
Spearmint oil (spearmint oil + native species and Scotch f?j), and the like. In particular, among these M, piperita L, 1m
Preferably, the oil extracted from The above mint oil may be used alone or in combination with two or more thereof, or may be used in combination with isolated or synthetic t-menthol or carmen. Further, the amount of t-menthol and carmen to be blended is preferably 0.01 to 2%, particularly 0.05 to 1%, based on the total composition.

Note that in the present invention, in addition to t-menthol and carmen, other essential oils and fragrance materials may be blended.1 Other ingredients of the present invention include appropriate ingredients depending on the type of oral composition. is used. For example, in the case of toothpaste, dicalcium phosphate dihydrate and anhydride, calcium carbonate, calcium pyrophosphate, calcium sulfate,
Abrasives such as insoluble sodium metaphosphate, amorphous silica, crystalline silica, aluminosilicate, aluminum hydroxide, aluminum oxide, resin, etc. (composition is usually 20 to 6
0), carboxymethyl cellulose, hydroxyethyl cellulose, alginate, carragnan, gum arabic, polyvinyl alcohol, etc.
), thickeners such as polyethylene glycol, sorbitol, glycerin, propylene glycol (10-70%)
, sodium lauryl sulfate, sodium dof/rubenzene sulfonate, hydrogenated coconut fatty acid monoglyceride mono-IA acid sodium, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosinate, N
- Foaming agents (0 to 5) such as acylglutamine #2 salt, lauryl jetanolamide, sucrose fatty acid ester,
Ingredients such as saccharin sodium, stevioside, neohesberidyl dihydrochalcone, glycyrrhizin, perillartin, p-methoxynonamicaldehyde, thaumatin, preservatives, and other ingredients are mixed with water, and the mixture is softened according to a conventional method. In addition, in mouthwashes and other mouthwashes, ingredients are appropriately blended depending on the properties of the product.

In addition, the oral composition of the present invention includes lysozyme chloride, dextranase, bacteriolytic acid, mutanase, chlorhexidine or its salt, sorbic acid, alexidine, hinokitiol, cetylpyridinium chloride, alkyl glycine, alkyl diaminoethyl glycine. salt, allantoin, ε−°amitsukagulonic acid, tranexamic acid,
Active ingredients such as azulene, vitamin E, sodium monofluorophosphate, sodium fluoride, 241tin fluoride, water-soluble primary or secondary phosphates, quaternary ammonium compounds, sodium chloride, and the like can also be blended.

Therefore, the oral composition according to the present invention uses sage extract and/or rosemary extract in combination with 1-menthol and/or carvone, so that they act synergistically. In addition, it effectively suppresses bad breath caused by the foul odor of CH and SH.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

[Experiment example]

Dry sage powder 100. Add methanol 300°C to Of, and place on a water bath at 70~:80°C with a cooling tube attached.
Refluxed for an hour. ``Next, the methanol fraction was separated in a furnace, fresh methanol was added to the residue, and the same reflux was repeated twice to perform the extraction operation three times in total.

The methanol extracts were collectively concentrated under reduced pressure to obtain 27.4 t of a dark green paste.

Also, add 301 parts of dry rosemary powder to 15 parts of methanol.
Add 0- and place it on a water bath at 70-80℃ with a cooling tube attached.
At time r, I was refluxed. The following procedure was carried out in the same manner as in the case of sage, to obtain 7.39 of a dark greenish-brown 1,.] compound.

Other solvents were operated in the same manner as above to obtain various extracts of sage and rosemary.

The extraction results are shown in Table 2 and 1.

Next, the person's I! I! io to 5000rl) m
115 minutes.

After removing solid matter (white blood cells, bacterial cells), transfer the 2.5-liter sample to a test tube with a diameter of 25 m and a height of 220 fins.
To this, various concentrations of sage and rosemary extracts were added with ethanol to give a concentration of 1.0, and then fragrance ingredients (essential oils) were added to the liquid at a Nik concentration of 1.
0.5 m of water bath solution containing 3SH (C city S of 100 nf) (
(containing) was added to the matsu, immediately dried, and incubated at 37°C for 5 minutes.

After the reaction, open the cap and test the 4 panel members (J(sSH)
A government evaluation was made based on the following evaluation criteria using the odor as an indicator.Evaluation criteria: 3 points: There is a strong CLESH odor.

2 points: C It smells like SH.

1 point: I doubt if it smells like CM, 81.

0 points: C) There is no smell of issH.

The results are shown in Table 2. The results are shown as an overall score of 4 and Otsu.

The results in Table 2 show the extracts of sage, rosemary and t.
- It was found that when used in combination with menthol or cargane, they act synergistically to eliminate the odor 1 of 0Hs8H.

Examples are shown below.

[Example 1] Toothpaste @ dicalcium phosphate dihydrate 50
%glycerin 20
Carboxymethyl cellulose 1
．． 0 Sodium lauryl sulfate 1. O L-menthol 0.
5 Anethole
0.2 sage methanol extract
O,OS saccharin
0.17 Sodium tsunide
0.1 allantoin
0.1 water
Remaining 100.0 [Example 2] Toothpaste dicalcium phosphate dihydrate 50
% sorbitol
10% glycerin
10 Sodium Rau Rusulfate
2.0 cal is xymethylcellulose
1.0 cal is 7
0.7 eugnol
0.05 sage 80 thiethanol extract
0.1 Sodium monofluorophosphate
0.3 ethanol
2.0 Satukarin
0.1 mutanase
0.1 water
Remaining 100.0% [Example 3] Toothpaste calcium carbonate 50
Tiglycerin 20 carragnan o,
5 cal is oxymethyl cellulose
1.0 lauryl diethanolamide
1.0 sucrose monolaurate 2.0 mint oil
0.8 chiseti petroleum ether extract
0.1 Satukarin
0.1 Chlorhexidine hydrochloride
0.005 dextranase
0.01 azulene
0.1100.0% [Example 4] Toothpaste dicalcium phosphate dihydrate 50
%glycerin 20
Calgaxymethylcellulose 2
．． 0 Sodium lauryl sulfate
2.0 Sushi mint oil
1.0 Sage water extract
0.1 Chlorhexidine gluconate
0.01 Satukarin
0.1 Glycyrrhizic acid ゛'0.2 Bentonite
0.5 water
Remaining It) (J, 0% Silicic anhydride 30 Tiglycerin 30 Sorbit
20 Sodium lauryl sulfate
2.0 cal is xymethyl cellulose
1. O2-menthol
0.5 Karzan
0.5 anethole
0.2 Saccharin 0.10-Acetone extract of Zumaryi 0.1 Tranexamic acid 0.1
water
Remaining 100.0% [Example 6] Oral use/duster polyoxyethylene monostearate 2.0% Sorbitan monooleate 2.0% cetyl alcohol, 2.0% lumityl alcohol
3.010 Pyrene glycol
15.0 carboxymethylcellulose
5.0% gelatin
1.0 Satukarin
0.2 sage methanol extract
0.1 petmint oil
0.5 spearmint oil
0.5 Lysozyme chloride s, ooo units Chlorhexidine hydrochloride 0.
01% water
Remaining 100.0% [Implementation f/l 7'3 Oral Pasta Glycerin Monolaurate 3.0% Decoy Alcohol 5.0
Polyethylene glycol 15
．． 0 white petrolatum
3.01'J -t9 Lumitoylglutamine r1 monosodium 0.5 Hydroxyethyl cellulose 5.0 Sage ethylene chloride extract 0.05 Tocopherol acetate 0.1 Chlorhexidine hydrochloride 0.01 Saccharin 0.2% Japanese pepper oil 0.
7 Cal Gun
0.5 anethole
03 Eugenol
0.1 water
100.0 remaining [Example 8] Mouthwash ethanol 20
．． 0% saccharin
0.05t-menthol
1.5 force A= g y
O, 5 linalool
0.1 Sodium monofluorophosphate 0.1 Chlorhexinone gluconate 0.01 Lauryl diethanolamide 0.3 N-hexane-methanol α:1) extract of sage 0
．． 1 Glycyrrhizinate
0.1 allantoin
0.1100.0chi [Example 9] Liquid toothpaste glycerin 35.0%
Monosodium N-cocoylglutamate 1.5
Kaladanan 1.
5 Katsupring Shugar 2
．． 0 ino arm - mint oil
0.7 Carmen
0.3 ethanol
1.0 Sodium monofluorophosphate
0.50-30% ethanolic extract of Zumaryi 0.05 Chlorhexidine hydrochloride
. , o1 water
100.0 tchi left [Example 10] Troche.

Gum arabic, 6.0% glucose, 72.0 gelatin, 1.3.0 fragrance 0
．． 2 dextranase
0.1 Chlorhexidine gluconate
0.01 seiso ethanol extract
0.1% t-menthol
0.1 suiamint oil
0.1 celery methanol extract
0.1 water
Remaining 100.0 pieces [Example 11] Chewing gum gum paste 40
,0% calcium carbonate
2.0 Starch syrup 15.0 Powdered sugar
40.0p/f-mint oil
0.2 dextranase
0.10-Zumary n-hexitine extract
0.1 water
Remaining 100.0% [Example 12]:::,1. Gargle Tablet Sodium Bicarbonate'' 54% Sodium Phosphate Dibasic 10 Polyethylene Glycol 3.0
Carbon 1.
0 Chipenogu-mint oil
1.0 Olein!
0.1 Sodium monofluorophosphate 0.1 Chlorhexidine hydrochloride 0.05 C. ethanol extract 0.050 - Ethanol extract of Zumaryi 0.05 Allantoin
0.1 citric acid
17. .

water
Remaining 100.0 pieces [Example 13] Powdered toothpaste dicalcium phosphate dihydrate 50
．． 0% calcium carbonate
30.0grise1)
10.0α-Olefin Sulfur 7O$-)1. O t-nontall 1.0
Satukarin 0.1
Sodium monofluorophosphate 0
．． 10-Methanol extract of Sumary 0.1 Dextran 0.5% Water
1 left
00.0%

Claims (1)

[Claims] sage extract and/or rosemary extract and t-
An oral composition characterized in that it is made in combination with menthol and/or carvone.